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Pesquisa : B01.650.940.800.575.912.250.987.849 [Categoria DeCS]
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[PMID]:28846699
[Au] Autor:Kaushik J; Tandon S; Gupta V; Nayyar J; Singla SK; Tandon C
[Ad] Endereço:Amity Institute of Biotechnology, Amity University, Noida, India.
[Ti] Título:Response surface methodology based extraction of Tribulus terrestris leads to an upsurge of antilithiatic potential by inhibition of calcium oxalate crystallization processes.
[So] Source:PLoS One;12(8):e0183218, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tribulus terrestris has significant antilithiatic efficacy established via both in vitro as well as in vivo studies and is used in numerous anti-urolithiatic herbal formulations viz. Cystone, Uriflow, Uritone and Neeri. However, to fully utilize its antilithiatic potential, the influence of different extraction parameters on antilithiatic ability of T. terrestris aqueous extract needs elucidation. Thus, the current study was undertaken using statistically optimized extraction conditions for aqueous extract preparation. Response surface methodology was employed to observe the influence of three variables i.e. temperature (°C), time (h) and solid: liquid ratio (S: L) on the extraction yield (%) and protein content (mg/g) of T. terrestris aqueous extract. RSM results revealed that the high S:L ratio, low temperature and reduced incubation time were optimal conditions for aqueous extraction. Under such extraction conditions the protein content reached the value of 26.6±1.22 mg/g and the obtained extraction yield was 27.32±1.62%. The assessment of antilithiatic activity of 4 selected extracts (AE1-4), revealed enhanced nucleation and aggregation inhibition of calcium oxalate crystals with AE1 and AE2, which in addition significantly altered the size and morphology of calcium oxalate monohydrate (COM) crystals compared to AE3 and AE4. In vitro cell culture based studies on renal epithelial cells (MDCK, NRK-52E and PK 15) proved that the AE1 showed higher cytoprotective potency by increasing cell viability as compared to the oxalate treated group. The free radical scavenging activity of aqueous extract lowered the reactive oxygen specie's induced damage and potentially reduced the signals of programmed cell death due to oxalate injury. In addition, modulation of the COM crystal morphology was enhanced by AE1 as compared to AE2. The FTIR and GC-MS analysis of AE1, showed the presence of biomolecules which could aid in the attenuation of lithiatic process. In the light of these results the utility of the RSM approach to fully optimize the antilithiatic potential of T. terrestris cannot be undermined.
[Mh] Termos MeSH primário: Oxalato de Cálcio/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Células Epiteliais/efeitos dos fármacos
Rim/efeitos dos fármacos
Extratos Vegetais/farmacologia
Tribulus
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Cristalização
Cães
Células Epiteliais/metabolismo
Rim/metabolismo
Ratos
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 2612HC57YE (Calcium Oxalate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183218


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[PMID]:28364864
[Au] Autor:Kamenov Z; Fileva S; Kalinov K; Jannini EA
[Ad] Endereço:Clinic of Endocrinology, Alexandrovska University Hospital, Medical University-Sofia, 1, Georgi Sofiiski Str 1431, Sofia, Bulgaria. Electronic address: zkamenov@hotmail.com.
[Ti] Título:Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial.
[So] Source:Maturitas;99:20-26, 2017 May.
[Is] ISSN:1873-4111
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The primary objectives were to compare the efficacy of extracts of the plant Tribulus terrestris (TT; marketed as Tribestan), in comparison with placebo, for the treatment of men with erectile dysfunction (ED) and with or without hypoactive sexual desire disorder (HSDD), as well as to monitor the safety profile of the drug. The secondary objective was to evaluate the level of lipids in blood during treatment. PARTICIPANTS AND DESIGN: Phase IV, prospective, randomized, double-blind, placebo-controlled clinical trial in parallel groups. This study included 180 males aged between 18 and 65 years with mild or moderate ED and with or without HSDD: 90 were randomized to TT and 90 to placebo. Patients with ED and hypertension, diabetes mellitus, and metabolic syndrome were included in the study. In the trial, an herbal medicine intervention of Bulgarian origin was used (Tribestan , Sopharma AD). Each Tribestan film-coated tablet contains the active substance Tribulus terrestris, herba extractum siccum (35-45:1) 250mg which is standardized to furostanol saponins (not less than 112.5mg). Each patient received orally 3×2 film-coated tablets daily after meals, during the 12-week treatment period. At the end of each month, participants' sexual function, including ED, was assessed by International Index of Erectile Function (IIEF) Questionnaire and Global Efficacy Question (GEQ). Several biochemical parameters were also determined. The primary outcome measure was the change in IIEF score after 12 weeks of treatment. Complete randomization (random sorting using maximum allowable% deviation) with an equal number of patients in each sequence was used. This randomization algorithm has the restriction that unequal treatment allocation is not allowed; that is, all groups must have the same target sample size. Patients, investigational staff, and data collectors were blinded to treatment. All outcome assessors were also blinded to group allocation. RESULTS: 86 patients in each group completed the study. The IIEF score improved significantly in the TT group compared with the placebo group (Р<0.0001). For intention-to-treat (ITT) there was a statistically significant difference in change from baseline of IIEF scores. The difference between TT and placebo was 2.70 (95% CI 1.40, 4.01) for the ITT population. A statistically significant difference between TT and placebo was found for Intercourse Satisfaction (p=0.0005), Orgasmic Function (p=0.0325), Sexual Desire (p=0.0038), Overall Satisfaction (p=0.0028) as well as in GEQ responses (p<0.0001), in favour of TT. There were no differences in the incidence of adverse events (AEs) between the two groups and the therapy was well tolerated. There were no drug-related serious AEs. Following the 12-week treatment period, significant improvement in sexual function was observed with TT compared with placebo in men with mild to moderate ED. TT was generally well tolerated for the treatment of ED.
[Mh] Termos MeSH primário: Disfunção Erétil/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Disfunções Sexuais Psicogênicas/tratamento farmacológico
Tribulus
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Disfunção Erétil/complicações
Seres Humanos
Libido
Masculino
Meia-Idade
Estudos Prospectivos
Disfunções Sexuais Psicogênicas/complicações
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE IV; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE


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[PMID]:28216339
[Au] Autor:Asadmobini A; Bakhtiari M; Khaleghi S; Esmaeili F; Mostafaei A
[Ad] Endereço:Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
[Ti] Título:The effect of Tribulus terrestris extract on motility and viability of human sperms after cryopreservation.
[So] Source:Cryobiology;75:154-159, 2017 Apr.
[Is] ISSN:1090-2392
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Semen cryopreservation produces significant amounts of reactive oxygen species (ROS), which may lead to impairment of sperm morphology, function, and ultimately, male fertility. Since Tribulus terrestris has antioxidant and free-radical-scavenging properties, this study aims to reveal the effect of the Tribulus terrestris extract on motility and vitality of human sperms after cryopreservation. MATERIALS AND METHODS: Semen specimens from 80 healthy volunteers were divided into eight groups: fresh control (group I), freeze control (group II), groups III, IV, and V, which had 20, 40, and 50 µg/mL doses of Tribulus terrestris extract added before cryopreservation, and groups VI, VII, and VIII, which were supplemented by these extract doses after the freeze-thaw process. To evaluate the effects of the Tribulus terrestris extract, the semen samples were incubated with the extract and evaluated with a light microscope for motility and viability. RESULTS: After cryopreservation, a significant improvement in spermatozoa viability was observed in group VII. In groups VII and VIII, motility, according to World Health Organization (WHO) criteria, increased considerably (p < 0.001). There was no significant difference among groups III, IV, and V. CONCLUSION: The present study demonstrated that the protective effects of Tribulus terrestris, which improves human sperm motility and viability, may be due to its antioxidant properties. On the basis of the results, the researchers concluded that Tribulus terrestris can be used as a safe therapeutic alternative to current modalities for the management of motility dysfunction in males.
[Mh] Termos MeSH primário: Criopreservação/métodos
Extratos Vegetais/farmacologia
Preservação do Sêmen/métodos
Motilidade Espermática/efeitos dos fármacos
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Espermatozoides/efeitos dos fármacos
Tribulus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:27982733
[Au] Autor:Sharma I; Khan W; Ahmad S
[Ad] Endereço:a Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Bioactive Natural Product Laboratory , Jamia Hamdard (Hamdard University) , New Delhi , India.
[Ti] Título:In vitro and ex vivo approach for anti-urolithiatic potential of bioactive fractions of gokhru with simultaneous HPLC analysis of six major metabolites and their exploration in rat plasma.
[So] Source:Pharm Biol;55(1):701-711, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Tribulus terrestris L. (Zygophyllaceae) fruits have long been used in traditional systems of medicine for the treatment of various urinary diseases including urolithiasis. OBJECTIVE: To explore the anti-urolithiatic potential of gokhru and to develop an analytical method for quantitative estimation of metabolites for its quality control. MATERIALS AND METHODS: Aqueous extract of gokhru fruit was prepared through maceration followed by decoction to produce a mother extract, which was further used for polarity-based fractionations. In vitro and ex vivo anti-urolithiatic activity of mother extract and fractions at different concentration (100-1000 µg/mL) were carried out using aggregation assay in synthetic urine and in rat plasma, however, nucleation assay for 30 min was done using confocal microscopy. A simultaneous HPLC method has been developed for quantification of diosgenin, catechin, rutin, gallic acid, tannic acid and quercetin in mother extract and in fractions. RESULTS: The extraction resulted in 14.5% of w/w mother extract, however, polarity-based fractionation yielded 2.1, 2.6, 1.5, 1.3 and 6.1% w/w of hexane, toluene, dichloromethane (DCM), n-butanol and water fractions, respectively. In vitro and ex vivo studies showed a significant anti-urolithiatic potential of n-butanol fraction. Further, HPLC analysis revealed significantly (p < 0.01) higher content of quercetin (1.95 ± 0.41% w/w), diosgenin (12.75 ± 0.18% w/w) and tannic acid (9.81 ± 0.47% w/w) in n-butanol fraction as compared to others fractions. DISCUSSION AND CONCLUSION: In vitro and ex vivo studies demonstrated potent anti-urolithiatic activity of n-butanol fraction which can be developed as new phytopharmaceuticals for urolithiasis. HPLC method can be used for quality control and pharmacokinetic studies of gokhru.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão
Extratos Vegetais/sangue
Tribulus/química
Urolitíase/tratamento farmacológico
Agentes Urológicos/sangue
[Mh] Termos MeSH secundário: 1-Butanol/química
Animais
Biotransformação
Oxalato de Cálcio/urina
Cristalização
Frutas
Microscopia Confocal
Ácido Oxálico/sangue
Fitoterapia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Ratos
Solventes/química
Urolitíase/sangue
Urolitíase/urina
Agentes Urológicos/administração & dosagem
Agentes Urológicos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Solvents); 0 (Urological Agents); 2612HC57YE (Calcium Oxalate); 8PJ61P6TS3 (1-Butanol); 9E7R5L6H31 (Oxalic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27717948
[Au] Autor:Stasiak M; Zarlok K; Tomaszewski W
[Ad] Endereço:Klinika Endokrynologii i Chorób Metabolicznych ICZMP, Lodz.
[Ti] Título:[Erectile dysfunction - treatment with substances of natural origin].
[So] Source:Wiad Lek;69(3 pt 2):576-581, 2016.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:The article discusses erectile dysfunction (ED) with the special emphasis on epidemiology, as well as the currently available medical treatments. Describing treatment methods authors paid special attention to natural therapies (as Panax ginseng, Tribulus terrestris, Vaccinium macrocarpon), because taking into consideration their safety profile, they appear to be an important alternative to therapies with synthetic molecules. From substances of natural origin, extract from the fruit of Tribulus terrestris ranks itself high on in collation at the end. The results of most clinical trials and experiments clearly demonstrate its effectiveness in improving sexual function in men.
[Mh] Termos MeSH primário: Disfunção Erétil/terapia
Fitoterapia
Extratos Vegetais/uso terapêutico
Tribulus
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE


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[PMID]:27711088
[Au] Autor:Sansalone S; Russo GI; Mondaini N; Cantiello F; Antonini G; Cai T
[Ad] Endereço:Department of Experimental Medicine and Surgery, University Tor Vergata, Rome. salvatore.sansalone@yahoo.it.
[Ti] Título:A combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts is able to improve sexual quality of life in patient with premature ejaculation.
[So] Source:Arch Ital Urol Androl;88(3):171-176, 2016 Oct 05.
[Is] ISSN:1124-3562
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The management of patient affected by premature ejaculation (PE) is nowadays not highly satisfactory. Here, we aimed to evaluate the tolerability and efficacy of a combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts in order to improve sexual quality of life in patients with premature ejaculation. MATERIALS AND METHODS: All patients attending to 5 urological centers from January 2015 to March 2015, due to premature ejaculation were enrolled in this study. At the enrolment visit, all subjects underwent self-administered IIEF-5, Male Sexual Health Questionnaire-Ejaculation Disorder (MSHQEjD), PEDT and IELTS (calculated as mean from that perceived by partner and that perceived by patient) and underwent urological visit and laboratory examinations. All patients received one tablet per day of a combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts for 3 months (Group A). After 3 months all patients underwent follow-up visit with the same investigations that have been carried out in the enrolment visit. The results were compared with a cohort of patients enrolled in the same period in another urological center and considered as a control group (Group B). All patients in the control group underwent counseling and sexual behavioral treatment without any pharmacological compound. RESULTS: At the follow-up analysis, significant changes in terms of IELT in the Group A (mean difference: 31.90; p < 0.05) at 3 months and versus Group B at the intergroup analysis (mean difference: 30.30; p < 0.05) were reported. In the group A, significant differences from baseline to last follow- up were observed relative to IIEF-5 (mean difference: 1.04; p < 0.05), PEDT (mean difference: -2.57; p < 0.05) and FSH (mean difference: -16.46; p < 0.05). CONCLUSION: In conclusion, patients affected by PE may significantly benefit from oral therapy with a combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts in terms of IELT and PEDT scores improvement.
[Mh] Termos MeSH primário: Extratos Vegetais/uso terapêutico
Ejaculação Precoce/tratamento farmacológico
Qualidade de Vida
Triptofano/uso terapêutico
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Terapia Comportamental/métodos
Combinação de Medicamentos
Seguimentos
Seres Humanos
Masculino
Phyllanthus emblica/química
Extratos Vegetais/administração & dosagem
Satureja/química
Inquéritos e Questionários
Resultado do Tratamento
Tribulus/química
Triptofano/administração & dosagem
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Plant Extracts); 8DUH1N11BX (Tryptophan)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170111
[Lr] Data última revisão:
170111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE
[do] DOI:10.4081/aiua.2016.3.171


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[PMID]:27681644
[Au] Autor:Tahvilzadeh M; Hajimahmoodi M; Toliyat T; Karimi M; Rahimi R
[Ad] Endereço:Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:An evidence-based approach to medicinal plants for the treatment of sperm abnormalities in traditional Persian medicine.
[So] Source:Andrologia;48(8):860-79, 2016 Oct.
[Is] ISSN:1439-0272
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Infertility is defined as inability of a sexually active couple to conceive after 1 year of regular intercourse without contraception. Male factors account for 20%-50% of cases of infertility. The aim of this study was to review medicinal plants that proposed to improve sperm abnormalities in traditional Persian medicine. For this purpose, PubMed, Scopus, GoogleScholar and Cochrane library were explored for medicinal plants used in traditional Persian medicine for sperm abnormalities to obtain studies giving any evidence for their efficacy and pharmacological mechanisms related to male infertility. Data were collected for the years 1966 to March 2015. For some of them, including Chlorophytum borivilianum, Crocus sativus, Nigella sativa, Sesamum indicum, Tribulus terrestris, Mucuna pruriens and Withania somnifera, more reliable evidence was found. The mechanisms involved in the beneficial effects of medicinal plants in sperm abnormalities are antioxidant, anti-inflammatory, anti-oedematous and venotonic activity as well as containing precursors for sperm production and increasing blood testosterone level. Various phytochemical categories including saponins, phytosterols, carotenoids, oxygenated volatile compounds, phenolic compounds and alkaloids seem to be responsible for these beneficial effects. Further studies are recommended for obtaining more conclusive results about the efficacy and safety of the mentioned medicinal plants.
[Mh] Termos MeSH primário: Astenozoospermia/tratamento farmacológico
Medicina Tradicional
Oligospermia/tratamento farmacológico
Fitoterapia
Preparações de Plantas/uso terapêutico
[Mh] Termos MeSH secundário: Alcaloides
Antioxidantes
Carotenoides
Clorófitas
Crocus
Medicina Baseada em Evidências
Seres Humanos
Infertilidade Masculina/tratamento farmacológico
Irã (Geográfico)
Masculino
Nigella sativa
Fenóis
Fitosteróis
Preparações de Plantas/química
Plantas Medicinais
Saponinas
Sesamum
Tribulus
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antioxidants); 0 (Phenols); 0 (Phytosterols); 0 (Plant Preparations); 0 (Saponins); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE
[do] DOI:10.1111/and.12676


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[PMID]:27655498
[Au] Autor:Shahid M; Riaz M; Talpur MM; Pirzada T
[Ad] Endereço:Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan.
[Ti] Título:Phytopharmacology of Tribulus terrestris.
[So] Source:J Biol Regul Homeost Agents;30(3):785-788, 2016 Jul-Sep.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Tribulus terrestris is an annual herb which belongs to the Zygophyllaceae family. This plant has been used in traditional medicine for the treatment of various diseases for hundreds of decades. The main active phytoconstituents of this plant include flavonoids, alkaloids, saponins, lignin, amides, and glycosides. The plant parts have different pharmacological activities including aphrodisiac, antiinflammatory, antimicrobial and antioxidant potential. T. terrestris is most often used for infertility and loss of libido. It has potential application as immunomodulatory, hepatoprotective, hypolipidemic, anthelmintic and anticarcinogenic activities. The aim of the present article is to create a database for further investigation of the phytopharmacological properties of this plant to promote research. This study will definitely help to confirm its traditional use along with its value-added utility, eventually leading to higher revenues from the plant.
[Mh] Termos MeSH primário: Fitoterapia
Extratos Vegetais/farmacologia
Tribulus/química
[Mh] Termos MeSH secundário: Animais
Ásia
Avaliação Pré-Clínica de Medicamentos
Mamíferos
Medicina Tradicional
Metanol
Extratos Vegetais/química
Plantas Medicinais/química
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts); 059QF0KO0R (Water); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170202
[Lr] Data última revisão:
170202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160923
[St] Status:MEDLINE


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[PMID]:27255456
[Au] Autor:Samani NB; Jokar A; Soveid M; Heydari M; Mosavat SH
[Ad] Endereço:Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:Efficacy of the Hydroalcoholic Extract of Tribulus terrestris on the Serum Glucose and Lipid Profile of Women With Diabetes Mellitus: A Double-Blind Randomized Placebo-Controlled Clinical Trial.
[So] Source:J Evid Based Complementary Altern Med;21(4):NP91-7, 2016 Oct.
[Is] ISSN:2156-5899
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: Considering traditional use of Tribulus terrestris in diabetes and proven antihyperglycemic and antihyperlipidemic effects of T terrestris in animal studies, we aimed to evaluate the efficacy of the hydroalcoholic extract of T terrestris on the serum glucose and lipid profile of women with non-insulin-dependent diabetes mellitus. METHODS: Ninety-eight women with diabetes mellitus type 2 were randomly allocated to receive the T terrestris (1000 mg/d) or placebo for 3 months. The patients were evaluated in terms of the fasting blood glucose, 2-hour postprandial glucose, glycosylated hemoglobin, and lipid profile. RESULTS: Tribulus terrestris showed a significant blood glucose-lowering effect in diabetic women compared to placebo (P < .05). Also, the total cholesterol and low-density lipoprotein of T terrestris group was significantly reduced compared with placebo, while no significant effect was observed in the triglyceride and high-density lipoprotein levels. CONCLUSIONS: The study showed preliminary promising hypoglycemic effect of T terrestris in women with diabetes mellitus type 2.
[Mh] Termos MeSH primário: Glicemia/efeitos dos fármacos
Diabetes Mellitus Tipo 2/metabolismo
Hipoglicemiantes/farmacologia
Lipídeos/sangue
Extratos Vegetais/farmacologia
Tribulus/química
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hipoglicemiantes/química
Meia-Idade
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Lipids); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160604
[St] Status:MEDLINE
[do] DOI:10.1177/2156587216650775


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[PMID]:27248990
[Au] Autor:Lewkowski J; Malinowski Z; Matusiak A; Morawska M; Rogacz D; Rychter P
[Ad] Endereço:Department of Organic Chemistry, Faculty of Chemistry, University of Łódź, Tamka 12, Łódź 91-403, Poland. jlewkow@uni.lodz.pl.
[Ti] Título:The Effect of New Thiophene-Derived Aminophosphonic Derivatives on Growth of Terrestrial Plants: A Seedling Emergence and Growth Test.
[So] Source:Molecules;21(6), 2016 May 30.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The aim of this work was to synthesize selected thiophene-derived aminophosphonic systems and evaluate the phytotoxicity of newly obtained products according to the OECD 208 Guideline. Seven new thiophene-derived N-substituted dimethyl aminomethylphosphonic acid esters 2a-h were synthesized by the addition of an appropriate phosphite to azomethine bond of starting Schiff bases 1a-h, and NMR spectroscopic properties of aminophosphonates were investigated. These eight compounds were analyzed in regard to their phytotoxicity towards two plants, radish (Raphanus sativus) and oat (Avena sativa). On the basis of the obtained results, it was found that tested aminophosphonates 2a-h showed an ecotoxicological impact against selected plants, albeit to various degrees.
[Mh] Termos MeSH primário: Tiofenos/química
Tiofenos/farmacologia
Tribulus/efeitos dos fármacos
Tribulus/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Raphanus/efeitos dos fármacos
Raphanus/crescimento & desenvolvimento
Plântulas/efeitos dos fármacos
Plântulas/crescimento & desenvolvimento
Tiofenos/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thiophenes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE



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