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[PMID]:29329336
[Au] Autor:Capdevila P; Linares C; Aspillaga E; Riera JL; Hereu B
[Ad] Endereço:Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
[Ti] Título:Effective dispersal and density-dependence in mesophotic macroalgal forests: Insights from the Mediterranean species Cystoseira zosteroides.
[So] Source:PLoS One;13(1):e0191346, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dispersal and recruitment are fundamental processes for population recovery following disturbances in sessile species. While both processes are well understood for many terrestrial species, they still remain poorly resolved for some macroalgal species. Here we experimentally investigated the effective dispersal and recruit survival of a mesophotic Mediterranean fucoid, Cystoseira zosteroides. In three isolated populations, four sets of settlement collectors were placed at increasing distances (from 0 to 10 m) and different orientations (North, South, East and West). We observed that effective dispersal was restricted to populations' vicinity, with an average of 6.43 m and not further than 13.33 m, following a Weibull distribution. During their first year of life, survival was up to 50%, but it was lower underneath the adult canopy, suggesting a negative density-dependence. To put our results in a broader context we compared the effective dispersal of other fucoid and kelp species reported in the literature, which confirmed the low dispersal ability of brown algae, in particular for fucoids, with an effective dispersal of few meters. Given the importance of recruitment for the persistence and recovery of populations after disturbances, these results underline the vulnerability of C. zosteroides and other fucoid species to escalating threats.
[Mh] Termos MeSH primário: Florestas
Feófitas/fisiologia
Dispersão Vegetal
[Mh] Termos MeSH secundário: Conservação dos Recursos Naturais
Ecossistema
Feófitas/crescimento & desenvolvimento
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191346


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[PMID]:27771480
[Au] Autor:Chan RT; Keating KS; Go MC; Toor N
[Ad] Endereço:Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
[Ti] Título:Identification of a GUAAY Pentaloop Sequence Involved in a Novel RNA Loop-Helix Interaction.
[So] Source:J Mol Biol;428(24 Pt B):4882-4889, 2016 12 04.
[Is] ISSN:1089-8638
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Large RNAs often utilize GNRA tetraloops as structural elements to stabilize the overall tertiary fold. These tetraloop-receptor (TR) interactions have a conserved geometry in which the tetraloop docks into the receptor at an angle of ~15° from the helix containing the receptor. Here, we show that the conserved GUAAY pentaloop found in domain III of group IIB1 introns participates in a novel class of RNA tertiary interaction with a geometry and mode of binding that are significantly different from that found in GNRA TR interactions. This pentaloop is highly conserved within the IIB1 class and interacts with the minor groove of the catalytic domain V. The base planes of the loop and receptor nucleotides are not coplanar and greatly deviate from standard A-minor motifs. The helical axis of the GUAAY stem loop diverges ~70° from the angle of insertion found in a typical GNRA TR interaction. Therefore, the loop architecture and insertion orientation are distinctive, with in vitro splicing data indicating that a GNRA tetraloop is incompatible at this position. The GUAAY pentaloop-receptor motif is also found in the structure of the eukaryotic thiamine pyrophosphate riboswitch in the context of a hexanucleotide loop sequence. We therefore propose, based on phylogenetic, structural, and biochemical data, that the GUAAY pentaloop-receptor interaction represents a novel structural motif that is present in multiple structured RNAs.
[Mh] Termos MeSH primário: Conformação de Ácido Nucleico
Feófitas/química
RNA/química
RNA/metabolismo
[Mh] Termos MeSH secundário: Feófitas/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
63231-63-0 (RNA)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE


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[PMID]:28873554
[Au] Autor:Ammar HH; Lajili S; Sakly N; Cherif D; Rihouey C; Le Cerf D; Bouraoui A; Majdoub H
[Ad] Endereço:Laboratoire des Interfaces et des Matériaux Avancés (LIMA), Faculté des Sciences de Monastir, Université de Monastir, Bd. de l'environnement, 5019 Monastir, Tunisia.
[Ti] Título:Influence of the uronic acid composition on the gastroprotective activity of alginates from three different genus of Tunisian brown algae.
[So] Source:Food Chem;239:165-171, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alginates from three genus of Tunisian brown algae were isolated and characterized by size exclusion chromatography and Solid-state NMR spectroscopy. Alginate from Padina pavonica (APP) had the highest molecular weight (Mw) with 147,000g/mol while it was 85,000g/mol for alginate from Cystoseira compressa (ACC) and 58,000g/mol for alginate from Dictyopteris membranaceae (ADM). The mannuronate (M) to guluronate (G) ratios were estimated from spectral deconvolution of the C CP/MAS spectra and the results has shown that all the extracts are mannuronic acid-rich alginates with M/G ratio increased in the order ADM - ACC - APP. An interesting gastroprotective effect was observed for the extracts; ADM and ACC exhibited the highest inhibition of gastric lesions, at 50mg/kg, with 83.41% and 75.39% respectively. Otherwise, it has been shown that the gastroprotective effect of alginates depends mainly on their uronic acid composition.
[Mh] Termos MeSH primário: Feófitas
[Mh] Termos MeSH secundário: Alginatos
Ácido Glucurônico
Ácidos Hexurônicos
Espectroscopia de Ressonância Magnética
Ácidos Urônicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (Hexuronic Acids); 0 (Uronic Acids); 8A5D83Q4RW (Glucuronic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:28961769
[Au] Autor:Bogaert KA; Beeckman T; De Clerck O
[Ad] Endereço:Department of Biology, Ghent University, Krijgslaan 281 S8, B-9000 Ghent, Belgium.
[Ti] Título:Egg activation-triggered shape change in the Dictyota dichotoma (Phaeophyceae) zygote is actin-myosin and secretion dependent.
[So] Source:Ann Bot;120(4):529-538, 2017 Oct 17.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background and Aims: Cellular morphogenesis in land plants and brown algae is typically a slow process involving growth established by an interplay of turgor pressure and cell wall rigidity. However, a recent study showed that zygotes of the brown alga Dictyota dichotoma undergo a rapid shape change from a sphere to an elongated spheroid in about 90 s, establishing the first body axis. Methods: Using a combination of pharmacology, staining techniques, membrane depolarization and microscopy techniques (brightfield, transmission electron microscopy and confocal laser scanning microscopy), egg activation and the shape change of the egg cell of D. dichotoma was studied. Key Results: It was established that elongation of the zygote does not involve growth, i.e. a positive change in size. The elongation is dependent on F-actin and myosin but independent of microtubules. Secretion was also found to be necessary for elongation after addition of brefeldin A. Moreover, a temporal correlation between extracellular matrix secretion and elongation was observed. Ionomycin and high potassium seawater are capable of triggering the onset of elongation, suggesting a role for membrane depolarization and calcium influx in the signalling mechanism. The elongated cells are shorter in the presence of ionomycin, suggesting a role for calcium in elongation. Conclusions: A model is proposed in which the fast elongation of the fertilized egg in Dictyota is accomplished by a force generated by F-actin and myosin, regulated by cytoplasmic calcium concentrations and by secretion during elongation lowering the antagonistic force. The finding of early extracellular matrix secretion, membrane depolarization and ionophore-triggered egg activation suggest significant differences in the mechanism of egg activation signalling between D. dichotoma and the oogamous brown algal model system Fucus .
[Mh] Termos MeSH primário: Actinas/fisiologia
Miosinas/fisiologia
Óvulo Vegetal/fisiologia
Feófitas/fisiologia
Sementes/fisiologia
[Mh] Termos MeSH secundário: Microscopia Confocal
Microscopia Eletrônica de Transmissão
Óvulo Vegetal/anatomia & histologia
Óvulo Vegetal/ultraestrutura
Feófitas/metabolismo
Feófitas/ultraestrutura
Sementes/anatomia & histologia
Sementes/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actins); EC 3.6.4.1 (Myosins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcx085


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[PMID]:28820110
[Au] Autor:Lee JH; Kang JW; Choe HN; Seong CN
[Ad] Endereço:1​Department of Biology, College of Life Science and Natural Resources, Sunchon National University, Suncheon 57922, Republic of Korea.
[Ti] Título:Flavivirga eckloniae sp. nov. and Flavivirga aquimarina sp. nov., isolated from seaweed Ecklonia cava.
[So] Source:Int J Syst Evol Microbiol;67(8):3089-3094, 2017 Aug.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two Gram-stain-negative, non-spore-forming, rod-shaped, aerobic and yellow-coloured bacterial strains, designated strains ECD14T and EC2D5T, were isolated from a seaweed Eckloniacava. The isolates required sea salts for growth. Flexirubin-type and carotenoid pigment was produced. The 16S rRNA gene sequence similarity between the two new strains was 95.5 %. Flavivirga amylovorans JC2681T was the nearest neighbour of strains ECD14T and EC2D5T with 96.5 and 96.8 % 16S rRNA gene sequence similarity, respectively. The common major fatty acids and respiratory quinones were iso-C15 : 0, iso-C15 : 1 G and unknown 13.565 and menaquinone 6 (MK-6), respectively. The common major polar lipids were phosphatidylethanolamine, an unknown amino lipid and an unknown lipid. The DNA G+C contents of strains ECD14T and EC2D5T were 33 and 31 mol%, respectively. On the basis of the polyphasic characterization of the two strains, it is suggested that the two isolates represent novel species of the genus Flavivirga, for which the names Flavivirga eckloniae sp. nov. (type strain, ECD14T=KCTC 52352T=JCM 31797T) and Flavivirga aquimarina sp. nov. (type strain, EC2D5T=KCTC 52353T=JCM 31796T) are proposed.
[Mh] Termos MeSH primário: Flavobacteriaceae/classificação
Feófitas/microbiologia
Filogenia
Alga Marinha/microbiologia
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
DNA Bacteriano/genética
Ácidos Graxos/química
Flavobacteriaceae/genética
Flavobacteriaceae/isolamento & purificação
Fosfatidiletanolaminas/química
Pigmentação
RNA Ribossômico 16S/genética
República da Coreia
Água do Mar/microbiologia
Análise de Sequência de DNA
Vitamina K 2/análogos & derivados
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phosphatidylethanolamines); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 39382-08-6 (phosphatidylethanolamine); 71ANL51TLA (menaquinone 6)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002094


  6 / 1692 MEDLINE  
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[PMID]:28764703
[Au] Autor:Rui X; Pan HF; Shao SL; Xu XM
[Ad] Endereço:Department of Urology, Ningbo No.2 Hospital, 41 Xibei Street, Ningbo, Zhejiang Province, 315010, China.
[Ti] Título:Anti-tumor and anti-angiogenic effects of Fucoidan on prostate cancer: possible JAK-STAT3 pathway.
[So] Source:BMC Complement Altern Med;17(1):378, 2017 Aug 01.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prostate cancer is the most common cancer in men in the United States. Fucoidan is a bioactive polysaccharide extracted mainly from algae. The aim of this study was to investigate anti-tumor and anti-angiogenic effects of fucoidan in both cell-based assays and mouse xenograft model, as well as to clarify possible role of JAK-STAT3 pathway in the protection. METHODS: DU-145 human prostate cancer cells were treated with 100-1000 µg/mL of fucoidan. Cell viability, proliferation, migration and tube formation were studied using MTT, EdU, Transwell and Matrigel assays, respectively. Athymic nude mice were subcutaneously injected with DU-145 cells to induce xenograft model, and treated by oral gavage with 20 mg/kg of fucoidan for 28 days. Tumor volume and weight were recorded. Vascular density in tumor tissue was determined by hemoglobin assay and endothelium biomarker analysis. Protein expression and phosphorylation of JAK and STAT3 were determined by Western blot. Activation of gene promoters was investigated by chromatin Immunoprecipitation. RESULTS: Fucoidan could dose-dependently inhibit cell viability and proliferation of DU-145 cells. Besides, fucoidan also inhibited cell migration in Transwell and tube formation in Matrigel. In animal study, 28-day treatment of fucoidan significantly hindered the tumor growth and inhibited angiogenesis, with decreased hemoglobin content and reduced mRNA expression of CD31 and CD105 in tumor tissue. Furthermore, phosphorylated JAK and STAT3 in tumor tissue were both reduced after fucoidan treatment, and promoter activation of STAT3-regulated genes, such as VEGF, Bcl-xL and Cyclin D1, was also significantly reduced after treatment. CONCLUSIONS: All these findings provided novel complementary and alternative strategies to treat prostate cancer.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Produtos Biológicos/farmacologia
Janus Quinases/metabolismo
Feófitas/química
Polissacarídeos/farmacologia
Neoplasias da Próstata/metabolismo
Fator de Transcrição STAT3/metabolismo
[Mh] Termos MeSH secundário: Inibidores da Angiogênese/farmacologia
Inibidores da Angiogênese/uso terapêutico
Animais
Antineoplásicos/uso terapêutico
Produtos Biológicos/uso terapêutico
Linhagem Celular Tumoral
Movimento Celular
Proliferação Celular
Sobrevivência Celular
Seres Humanos
Masculino
Camundongos
Camundongos Nus
Polissacarídeos/uso terapêutico
Regiões Promotoras Genéticas
Neoplasias da Próstata/tratamento farmacológico
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Antineoplastic Agents); 0 (Biological Products); 0 (Polysaccharides); 0 (STAT3 Transcription Factor); 9072-19-9 (fucoidan); EC 2.7.10.2 (Janus Kinases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1885-y


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[PMID]:28720331
[Au] Autor:Park BG; Shin WS; Oh S; Park GM; Kim NI; Lee S
[Ad] Endereço:Department of Physiology, Catholic Kwandong University College of Medicine, Gangneung 25601, Republic of Korea; Institute for Clinical and Translational Research, Catholic Kwandong University College of Medicine, Gangneung 25601, Republic of Korea.
[Ti] Título:A novel antihypertension agent, sargachromenol D from marine brown algae, Sargassum siliquastrum, exerts dual action as an L-type Ca channel blocker and endothelin A/B receptor antagonist.
[So] Source:Bioorg Med Chem;25(17):4649-4655, 2017 Sep 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We isolated the novel vasoactive marine natural products, (5E,10E)-14-hydroxy-2,6,10-trimethylpentadeca-5,10-dien-4-one (4) and sargachromenol D (5), from Sargassum siliquastrum collected from the coast of the East Sea in South Korea by using activity-guided HPLC purification. The compounds effectively dilated depolarization (50mMK )-induced basilar artery contraction with EC values of 3.52±0.42 and 1.62±0.63µM, respectively, but only sargachromenol D (5) showed a vasodilatory effect on endothelin-1 (ET-1)-induced basilar artery contraction (EC =9.8±0.6µM). These results indicated that sargachromenol D (5) could act as a dual antagonist of l-type Ca channel and endothelin A/B receptors. Moreover, sargachromenol D (5) lowered blood pressure in spontaneous hypertensive rats (SHRs) 2h after oral treatment at a dose of 80mg/kg dose and the effect was maintained for 24h. Based on our ex vivo and in vivo experiments, we propose that sargachromenol D (5) is a strong candidate for the treatment of hypertension that is not controlled by conventional drugs, in particular, severe-, type II diabetes-, salt-sensitive, and metabolic disease-induced hypertension.
[Mh] Termos MeSH primário: Anti-Hipertensivos/química
Benzopiranos/química
Bloqueadores dos Canais de Cálcio/química
Antagonistas do Receptor de Endotelina A/química
Antagonistas do Receptor de Endotelina B/química
Feófitas/química
[Mh] Termos MeSH secundário: Administração Oral
Animais
Anti-Hipertensivos/isolamento & purificação
Anti-Hipertensivos/farmacologia
Artéria Basilar/efeitos dos fármacos
Artéria Basilar/fisiologia
Benzopiranos/isolamento & purificação
Benzopiranos/farmacologia
Pressão Sanguínea/efeitos dos fármacos
Bloqueadores dos Canais de Cálcio/isolamento & purificação
Bloqueadores dos Canais de Cálcio/farmacologia
Canais de Cálcio Tipo L/química
Canais de Cálcio Tipo L/metabolismo
Antagonistas do Receptor de Endotelina A/isolamento & purificação
Antagonistas do Receptor de Endotelina A/farmacologia
Antagonistas do Receptor de Endotelina B/isolamento & purificação
Antagonistas do Receptor de Endotelina B/farmacologia
Masculino
Feófitas/metabolismo
Coelhos
Ratos
Ratos Endogâmicos SHR
Receptor de Endotelina A/química
Receptor de Endotelina A/metabolismo
Receptor de Endotelina B/química
Receptor de Endotelina B/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Benzopyrans); 0 (Calcium Channel Blockers); 0 (Calcium Channels, L-Type); 0 (Endothelin A Receptor Antagonists); 0 (Endothelin B Receptor Antagonists); 0 (Receptor, Endothelin A); 0 (Receptor, Endothelin B); 0 (sargachromenol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE


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[PMID]:28704687
[Au] Autor:Chakraborty K; Thilakan B; Raola VK
[Ad] Endereço:Marine Bioprospecting Section of Biotechnology Division, Central Marine Fisheries Research Institute, Ernakulam North, P.B. No. 1603, Cochin, 682018, Kerala, India. Electronic address: kajal_cmfri@yahoo.com.
[Ti] Título:Antimicrobial polyketide furanoterpenoids from seaweed-associated heterotrophic bacterium Bacillus subtilis MTCC 10403.
[So] Source:Phytochemistry;142:112-125, 2017 Oct.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Brown seaweed Anthophycus longifolius (Turner) Kützing (family Sargassaceae) associated heterotrophic bacterium Bacillus subtilis MTCC 10403 was found to be a potent isolate with broad range of antibacterial activity against important perceptive food pathogens Vibrio parahaemolyticus, V. vulnificus, and Aeromonas hydrophila. This bacterium was positive for polyketide synthetase gene (KC589397), and therefore, was selected to bioprospect specialized metabolites bearing polyketide backbone. Bioactivity-guided chromatographic fractionation of the ethyl acetate extract of the seaweed-associated bacterium segregated four homologous polyketide furanoterpenoids with potential antibacterial activities against clinically important pathogens. The minimum inhibitory concentration (MIC) assay showed that the referral antibiotics tetracycline and ampicillin were active at 25 µg/mL against the test pathogens, whereas the previously undescribed (4E)-methyl 13-((16-(furan-2-yl) ethyl)-octahydro-7-hydroxy-4-((E)-23-methylbut-21-enyl)-2H-chromen-6-yl)-4-methylpent-4-enoate (compound 1) and methyl 3-(hexahydro-9-((E)-3-methylpent-1-enyl)-4H-furo[3,2-g]isochromen-6-yl) propanoate (compound 3) displayed antibacterial activities against the test pathogens at a lesser concentration (MIC < 7 µg/mL). The title compounds were characterized by comprehensive nuclear magnetic resonance and mass spectroscopic experiments. Polyketide synthase catalyzed putative biosynthetic mechanism additionally corroborated the structural ascriptions of the hitherto undescribed furanoterpenoids from seaweed-associated bacterial symbiont. The electronic and hydrophobic parameters appeared to hold a conspicuous part in directing the antibacterial properties of the compounds. Seaweed-associated B. subtilis MTCC 10403 demonstrated to represent a potential source of antimicrobial polyketides for pharmaceutical applications.
[Mh] Termos MeSH primário: Anti-Infecciosos/isolamento & purificação
Anti-Infecciosos/farmacologia
Policetídeos/farmacologia
Terpenos/isolamento & purificação
Terpenos/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Anti-Infecciosos/química
Bacillus subtilis/metabolismo
Processos Heterotróficos
Testes de Sensibilidade Microbiana
Feófitas/química
Policetídeo Sintases/metabolismo
Policetídeos/química
Policetídeos/isolamento & purificação
Alga Marinha/metabolismo
Terpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Polyketides); 0 (Terpenes); 79956-01-7 (Polyketide Synthases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE


  9 / 1692 MEDLINE  
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[PMID]:28532321
[Au] Autor:Desideri D; Meli MA; Roselli C; Feduzi L; Ugolini L
[Ad] Endereço:a Department of Biomolecular Sciences , Urbino University "Carlo Bo" , Urbino , Italy.
[Ti] Título:Polonium bioaccessibility assessment in algae for human consumption: An in vitro gastrointestinal digestion method.
[So] Source:J Toxicol Environ Health A;80(4):230-235, 2017.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The occurrence and mobility of natural radioactive element as Polonium ( Po) in 13 commercial algae consumed in Italy by humans were determined because the effects on human health need to take into account the bioavailability of these elements. The simulation of gastrointestinal (GIT) digestion was divided into three stages and was accomplished using three different artificial solutions: saliva, gastric, and synthetic bile-pancreas solution. The same sample was treated in two different ways: a) only gastric digestion and b) complete GIT digestion (gastric digestion followed by bile-pancreas solution). The difference between Po gastric mobility with respect to that found for GIT digestion was not significant; in fact, Po mobility exhibited a mean value 17.2 ± 15.1% and 19.5 ± 11.5% for gastric and GIT digestion, respectively.
[Mh] Termos MeSH primário: Digestão
Polônio/farmacocinética
Poluentes Radioativos da Água/farmacocinética
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Clorófitas/química
Cianobactérias/química
Trato Gastrointestinal/metabolismo
Seres Humanos
Itália
Modelos Biológicos
Feófitas/química
Rodófitas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Radioactive); DQY03U61EJ (Polonium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1285733


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[PMID]:28476987
[Au] Autor:Rajeshkumar S
[Ad] Endereço:School of Bio-Sciences and Technology, VIT University, Vellore, Tamil Nadu, India. ssrajeshkumar@hotmail.com.
[Ti] Título:Phytochemical constituents of fucoidan ( ) and its assisted AgNPs for enhanced antibacterial activity.
[So] Source:IET Nanobiotechnol;11(3):292-299, 2017 Apr.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Biological synthesis of nanomaterials is a growing innovative approach and it was broadly utilised in the field of nanotechnology and nanomedicine. This study illustrates that biosynthesis of silver nanoparticles (AgNPs) using fucoidan extracted from seaweed . The functional groups of extracted fucoidan were characterised by Fourier transform infrared spectroscopy (FTIR) and used to NPs synthesis. Synthesised AgNPs were characterised by ultraviolet-visible spectra, scanning electron microscope, energy dispersive X-ray, transmission electron microscope, selected area electron diffraction and FTIR. In this study, their main focus is enhancement antibacterial activity of AgNPs coated antibiotics against antibiotic resistant bacteria. Among the microorganisms, was resistant to novobiocin and penicillin, but it was sensitive to AgNPs impregnated antibiotic discs. The zone of inhibition was 12 and 15 mm. The synergistic effect of combined antibiotics and AgNPs resulted in increased fold area which was greater than the sum of their separate effects. It reveals that AgNPs are highly sought in the medicinal field due to their broad spectrum of antibacterial activity and relatively cheaper. This enhanced synergistic effect potentially superior to control the growth of bacteria and it is the budding process for the development of new remedial agents for severe diseases.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Bacterianos/efeitos dos fármacos
Nanopartículas Metálicas/administração & dosagem
Feófitas/química
Polissacarídeos/química
Prata/administração & dosagem
Prata/química
[Mh] Termos MeSH secundário: Antibacterianos/administração & dosagem
Antibacterianos/síntese química
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/fisiologia
Relação Dose-Resposta a Droga
Teste de Materiais
Nanopartículas Metálicas/química
Nanopartículas Metálicas/ultraestrutura
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Polysaccharides); 3M4G523W1G (Silver); 9072-19-9 (fucoidan)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0099



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