Base de dados : MEDLINE
Pesquisa : B01.750.600.800 [Categoria DeCS]
Referências encontradas : 122 [refinar]
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[PMID]:28387729
[Au] Autor:Park JH; Choi SH; Park SJ; Lee YJ; Park JH; Song PH; Cho CM; Ku SK; Song CH
[Ad] Endereço:Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea. kjadjh123@naver.com.
[Ti] Título:Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model.
[So] Source:Mar Drugs;15(4), 2017 Apr 07.
[Is] ISSN:1660-3397
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Low molecular weight fucoidan (LMF) has been reported to possess anti-inflammatory and antioxidant activities. Thus, we examined the effects of LMF extracted from on dermal wounds. Five round dermal wounds were created on the dorsal back of rats, and they were then treated topically with distilled water (DW), Madecasol Care™ (MC) or LMF at 200, 100 and 50 mg/mL, twice a day for a week. There were dose-dependent increases in wound contraction in the groups receiving LMF but not in the MC group, compared with the DW. Histopathological examination revealed that LMF treatment accelerated wound healing, which was supported by increases in granular tissue formation on day four post-treatment but a decrease on day seven, accompanied by an evident reduction in inflammatory cells. In the LMF-treated wounds, collagen distribution and angiogenesis were increased in the granular tissue on days four and seven post-treatment. Immunoreactive cells for transforming growth factor-ß1, vascular endothelial growth factor receptor-2 or matrix metalloproteinases 9 were also increased, probably due to tissue remodeling. Furthermore, LMF treatment reduced lipid peroxidation and increased antioxidant activities. These suggested that LMF promotes dermal wound healing via complex and coordinated antioxidant, anti-inflammatory and growth factor-dependent activities.
[Mh] Termos MeSH primário: Polissacarídeos/farmacologia
Pele/efeitos dos fármacos
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Colágeno/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Peso Molecular
Extratos Vegetais/farmacologia
Ratos
Ratos Sprague-Dawley
Fator de Crescimento Transformador beta1/metabolismo
Undaria/química
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Plant Extracts); 0 (Polysaccharides); 0 (Transforming Growth Factor beta1); 0 (Vascular Endothelial Growth Factor A); 9007-34-5 (Collagen); 9072-19-9 (fucoidan)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE


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[PMID]:28104371
[Au] Autor:Phull AR; Majid M; Haq IU; Khan MR; Kim SJ
[Ad] Endereço:Department of Biological Sciences, College of Natural Sciences, Kongju National University, 56 Gongju Daehak-Ro, Gongju-Si, Chungnam 32588, Republic of Korea.
[Ti] Título:In vitro and in vivo evaluation of anti-arthritic, antioxidant efficacy of fucoidan from Undaria pinnatifida (Harvey) Suringar.
[So] Source:Int J Biol Macromol;97:468-480, 2017 Apr.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Seaweed and their constituents have been traditionally employed for the management of various human pathologic conditions such as edema, urinary disorders and inflammatory anomalies. The current study was performed to investigate the antioxidant and anti-arthritic effects of fucoidan from Undaria pinnatifida. A noteworthy in vitro antioxidant potential at 500µg/ml in 2, 2-diphenyl-1-picrylhydrazyl scavenging assay (80% inhibition), nitrogen oxide inhibition assay (71.83%), hydroxyl scavenging assay (71.92%), iron chelating assay (73.55%) and a substantial ascorbic acid equivalent reducing power (399.35µg/mg ascorbic acid equivalent) and total antioxidant capacity (402.29µg/mg AAE) suggested fucoidan a good antioxidant agent. Down regulation of COX-2 expression in rabbit articular chondrocytes in a dose (0-100µg) and time (0-48h) dependent manner, unveiled its in vitro anti-inflammatory significance. In vivo carrageenan induced inflammatory rat model demonstrated a 68.19% inhibition of inflammation whereas an inflammation inhibition potential of 79.38% was recorded in anti-arthritic complete Freund's adjuvant-induced arthritic rat model. A substantial ameliorating effect on altered hematological and biochemical parameters in arthritic rats was also observed. Therefore, findings of the present study prospects fucoidan as a potential antioxidant that can effectively abrogate oxidative stress, edema and arthritis-mediated inflammation and mechanistic studies are recommended for observed activities.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Artrite Reumatoide/tratamento farmacológico
Polissacarídeos/farmacologia
Undaria/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/uso terapêutico
Antioxidantes/toxicidade
Artrite Reumatoide/induzido quimicamente
Artrite Reumatoide/metabolismo
Artrite Reumatoide/patologia
Condrócitos/efeitos dos fármacos
Condrócitos/patologia
Edema/induzido quimicamente
Edema/tratamento farmacológico
Adjuvante de Freund/farmacologia
Testes Hematológicos
Articulações/efeitos dos fármacos
Articulações/metabolismo
Articulações/patologia
Masculino
Estresse Oxidativo/efeitos dos fármacos
Polissacarídeos/uso terapêutico
Polissacarídeos/toxicidade
Coelhos
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Polysaccharides); 9007-81-2 (Freund's Adjuvant); 9072-19-9 (fucoidan)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


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[PMID]:28060735
[Au] Autor:Thakur V; Lu J; Roscilli G; Aurisicchio L; Cappelletti M; Pavoni E; White WL; Bedogni B
[Ad] Endereço:Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
[Ti] Título:The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition.
[So] Source:Oncotarget;8(11):17887-17896, 2017 Mar 14.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Melanoma remains one of the most aggressive and therapy-resistant cancers. Finding new treatments to improve patient outcomes is an ongoing effort. We previously demonstrated that melanoma relies on the activation of ERBB signaling, specifically of the ERBB3/ERBB2 cascade. Here we show that melanoma tumor growth is inhibited by 60% over controls when treated with lapatinib, a clinically approved inhibitor of ERBB2/EGFR. Importantly, tumor growth is further inhibited to 85% when the natural compound fucoidan from New Zealand U. pinnatifida is integrated into the treatment regimen. Fucoidan not only enhances tumor growth inhibition, it counteracts the morbidity associated with prolonged lapatinib treatment. Fucoidan doubles the cell killing capacity of lapatinib. These effects are associated with a further decrease in AKT and NFκB signaling, two key pathways involved in melanoma cell survival. Importantly, the enhancing cell killing effects of fucoidan can be recapitulated by inhibiting ERBB3 by either a specific shRNA or a novel, selective ERBB3 neutralizing antibody, reiterating the key roles played by this receptor in melanoma. We therefore propose the use of lapatinib or specific ERBB inhibitors, in combination with fucoidan as a new treatment of melanoma that potentiates the effects of the inhibitors while protecting from their potential side effects.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia
Proliferação Celular/efeitos dos fármacos
Melanoma/metabolismo
Polissacarídeos/farmacologia
Quinazolinas/farmacologia
Receptor ErbB-2/antagonistas & inibidores
Receptor ErbB-3/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Sinergismo Farmacológico
Seres Humanos
Masculino
Melanoma/tratamento farmacológico
Camundongos
Camundongos SCID
Nova Zelândia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Interferência de RNA
RNA Interferente Pequeno/genética
Receptor do Fator de Crescimento Epidérmico/antagonistas & inibidores
Receptor ErbB-2/metabolismo
Receptor ErbB-3/genética
Receptor ErbB-3/metabolismo
Fator de Transcrição RelA/metabolismo
Undaria/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Polysaccharides); 0 (Quinazolines); 0 (RELA protein, human); 0 (RNA, Small Interfering); 0 (Transcription Factor RelA); 0VUA21238F (lapatinib); 9072-19-9 (fucoidan); EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (ERBB2 protein, human); EC 2.7.10.1 (ERBB3 protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); EC 2.7.10.1 (Receptor, ErbB-2); EC 2.7.10.1 (Receptor, ErbB-3); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.14437


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[PMID]:28056369
[Au] Autor:Chen Y; Ren X; Wei Q
[Ad] Endereço:Harbin Institute of Technology, School of Marine Science and Technology, West Culture Road 2, Weihai, Shandong, China.
[Ti] Título:Conversion of Undaria pinnatifida residue to glycolic acid with recyclable methylamine in low temperature hydrothermal liquefaction.
[So] Source:Bioresour Technol;228:47-55, 2017 Mar.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The conversion of Undaria pinnatifida residue to glycolic acid was carried out using methylamine as catalyst by hydrothermal method at relatively low temperature. GC-MS and HPLC were used to identify the composition of bio-oil and liquid products which provide the knowledge of the chemical reaction pathways of the hydrothermal liquefaction. The main liquid product was organic acid which contained glycolic acid, lactic acid, formic acid and acetic acid. And the major organic acid was glycolic acid with the highest yield of 46.52% or 33.98% of dry biomass. Methylamine promoted the dissolution of cellulose from Undaria pinnatifida residue, and significantly improved the yield of glycolic acid. The mechanism of HTL was investigated and the results show that the carbocation C was attacked by methylamine molecule which led to the high yield of glycolic acid. In addition, the recovery of methylamine was studied and the highest recovery rate reached 99.28%.
[Mh] Termos MeSH primário: Biotecnologia/métodos
Glicolatos/síntese química
Metilaminas/química
Undaria/química
[Mh] Termos MeSH secundário: Biomassa
Celulose/química
Cromatografia Líquida de Alta Pressão
Temperatura Baixa
Cromatografia Gasosa-Espectrometria de Massas
Glicolatos/química
Ácido Láctico/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycolates); 0 (Methylamines); 059QF0KO0R (Water); 0WT12SX38S (glycolic acid); 33X04XA5AT (Lactic Acid); 9004-34-6 (Cellulose); BSF23SJ79E (methylamine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE


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[PMID]:27668881
[Au] Autor:Chen Y; Ren X; Wei Q; Guo J
[Ad] Endereço:Harbin Institute of Technology, School of Marine Science and Technology, West Culture Road 2, Weihai, Shandong, China.
[Ti] Título:Hydrothermal liquefaction of Undaria pinnatifida residues to organic acids with recyclable trimethylamine.
[So] Source:Bioresour Technol;221:477-484, 2016 Dec.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the effect of trimethylamine (TMA) on the hydrothermal liquefaction (HTL) process and the recycle of TMA. The results suggest that the peeling reaction occurred on the surface and the cleavage of cellulose leading to water-soluble substances and bio-oil. The highest content of organic acids was found in the water-soluble phase. Model compounds, different glucides with TMA were used to investigate the mechanism of the HTL. Results suggest that the OH appeared to selectively interact with C-O-C bonds, and thus causing the key linkages of cellulose to become much easier to be cleaved under mild conditions. In addition, the conditions for TMA recovery were optimized and the highest TMA recovery rate reached 98.89%. The recovered TMA had the same properties as the original compound, and it was perfectly re-usable in the conversion process of HTL.
[Mh] Termos MeSH primário: Biocombustíveis
Metilaminas/química
Undaria
[Mh] Termos MeSH secundário: Compostos Orgânicos
Temperatura Ambiente
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biofuels); 0 (Methylamines); 0 (Organic Chemicals); 059QF0KO0R (Water); LHH7G8O305 (trimethylamine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170923
[Lr] Data última revisão:
170923
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


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[PMID]:27527189
[Au] Autor:Grasa-López A; Miliar-García Á; Quevedo-Corona L; Paniagua-Castro N; Escalona-Cardoso G; Reyes-Maldonado E; Jaramillo-Flores ME
[Ad] Endereço:Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, Mexico. ameyalli.grasa@gmail.com.
[Ti] Título:Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity.
[So] Source:Mar Drugs;14(8), 2016 Aug 03.
[Is] ISSN:1660-3397
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, ß-oxidation and adipogenesis by upregulating PPARα, PGC1α, PPARγ and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density. Additionally, the treatments, ameliorated adipose tissue accumulation, insulin resistance, blood pressure, cholesterol and triglycerides concentration in serum, and reduced lipogenesis and inflammation by downregulating acetyl-CoA carboxylase (ACC) gene expression, increasing serum concentration and expression of adiponectin as well as downregulating IL-6 expression. Both fucoxanthin and Undaria pinnatifida may be considered for treating obesity and other diseases related.
[Mh] Termos MeSH primário: Dieta Vegetariana/métodos
Lipogênese/efeitos dos fármacos
Obesidade/dietoterapia
Feófitas/química
Undaria/química
Xantofilas/farmacologia
[Mh] Termos MeSH secundário: Acetil-CoA Carboxilase/metabolismo
Adiponectina/sangue
Adiponectina/metabolismo
Tecido Adiposo Branco/metabolismo
Animais
Biomarcadores/metabolismo
Dieta Hiperlipídica/efeitos adversos
Modelos Animais de Doenças
Seres Humanos
Inflamação/dietoterapia
Interleucina-6/metabolismo
Masculino
Síndrome Metabólica/dietoterapia
Obesidade/etiologia
PPAR alfa/metabolismo
PPAR gama/metabolismo
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo
Ratos
Ratos Wistar
Proteína Desacopladora 1/metabolismo
Xantofilas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adiponectin); 0 (Adipoq protein, rat); 0 (Biomarkers); 0 (Interleukin-6); 0 (PPAR alpha); 0 (PPAR gamma); 0 (PPAR gamma, rat); 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha); 0 (Ppargc1a protein, rat); 0 (Ucp1 protein, rat); 0 (Uncoupling Protein 1); 0 (Xanthophylls); 06O0TC0VSM (fucoxanthin); EC 6.4.1.2 (Acetyl-CoA Carboxylase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160817
[St] Status:MEDLINE


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[PMID]:27384013
[Au] Autor:Kim BM; Park JH; Kim DS; Kim YM; Jun JY; Jeong IH; Chi YM
[Ad] Endereço:Div. of Biotechnology, College of Life Sciences and Biotechnology, Korea Univ, Seoul, 136-713, Republic of Korea.
[Ti] Título:Effects of the Polysaccharide from the Sporophyll of Brown Alga Undaria Pinnatifida on Serum Lipid Profile and Fat Tissue Accumulation in Rats Fed a High-Fat Diet.
[So] Source:J Food Sci;81(7):H1840-5, 2016 Jul.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the effects of the polysaccharide from the sporophyll of a selected brown alga Undaria pinnatifida on serum lipid profile, fat tissue accumulation, and gastrointestinal transit time in rats fed a high-fat diet. The algal polysaccharide (AP) was prepared by the treatment of multiple cellulase-producing fungi Trichoderma reesei and obtained from the sporophyll with a yield of 38.7% (dry basis). The AP was mostly composed of alginate and fucoidan (up to 89%) in a ratio of 3.75:1. The AP was added to the high-fat diet in concentrations of 0.6% and 1.7% and was given to male Sprague-Dawley rats (5-wk-old) for 5 wk. The 1.7% AP addition notably reduced body weight gain and fat tissue accumulation, and it improved the serum lipid profile, including triglycerides, total cholesterol, and very low-density lipoprotein-cholesterol. The effects were associated with increased feces weight and shortened gastrointestinal transit time. In addition, the lipid peroxidation of the liver was decreased in both groups.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Dieta Hiperlipídica
Gorduras na Dieta/metabolismo
Lipídeos/sangue
Preparações de Plantas/farmacologia
Polissacarídeos/farmacologia
Undaria/química
[Mh] Termos MeSH secundário: Alginatos/análise
Alginatos/farmacologia
Animais
Colesterol/sangue
Trânsito Gastrointestinal/efeitos dos fármacos
Ácido Glucurônico/análise
Ácido Glucurônico/farmacologia
Ácidos Hexurônicos/análise
Ácidos Hexurônicos/farmacologia
Peroxidação de Lipídeos/efeitos dos fármacos
Lipoproteínas LDL/sangue
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Preparações de Plantas/química
Estruturas Vegetais
Polissacarídeos/análise
Ratos
Ratos Sprague-Dawley
Triglicerídeos/sangue
Ganho de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (Dietary Fats); 0 (Hexuronic Acids); 0 (Lipids); 0 (Lipoproteins, LDL); 0 (Plant Preparations); 0 (Polysaccharides); 0 (Triglycerides); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); 9072-19-9 (fucoidan); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13335


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[PMID]:27283644
[Au] Autor:Zhu J; Sun X; Chen X; Wang S; Wang D
[Ad] Endereço:College of Food Science and Engineering, Ocean University of China, Qingdao 266003, People's Republic of China.
[Ti] Título:Chemical cleavage of fucoxanthin from Undaria pinnatifida and formation of apo-fucoxanthinones and apo-fucoxanthinals identified using LC-DAD-APCI-MS/MS.
[So] Source:Food Chem;211:365-73, 2016 Nov 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:As the most abundant carotenoid in nature, fucoxanthin is susceptible to oxidation under some conditions, forming cleavage products that possibly exhibit both positive and negative health effects in vitro and in vivo. Thus, to produce relatively high amounts of cleavage products, chemical oxidation of fucoxanthin was performed. Kinetic models for oxidation were probed and reaction products were identified. The results indicated that both potassium permanganate (KMnO4) and hypochlorous acid/hypochlorite (HClO/ClO(-)) treatment fitted a first-order kinetic model, while oxidation promoted by hydroxyl radical (OH) followed second-order kinetics. With the help of liquid chromatography-tandem mass spectrometry, a total of 14 apo-fucoxanthins were detected as predominant cleavage products, with structural and geometric isomers identified among them. Three apo-fucoxanthinones and eleven apo-fucoxanthinals, of which five were cis-apo-fucoxanthinals, were detected upon oxidation by the three oxidizing agents (KMnO4, HClO/ClO(-), and OH).
[Mh] Termos MeSH primário: Espectrometria de Massas em Tandem/métodos
Undaria
Xantinas/análise
Xantinas/química
Xantofilas/análise
Xantofilas/química
[Mh] Termos MeSH secundário: Pressão Atmosférica
Carotenoides/análise
Carotenoides/química
Cromatografia Líquida de Alta Pressão/métodos
Cromatografia Líquida/métodos
Undaria/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Xanthines); 0 (Xanthophylls); 06O0TC0VSM (fucoxanthin); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE


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[PMID]:26860657
[Au] Autor:Murphy JT; Johnson MP; Viard F
[Ad] Endereço:Sorbonne Universités, UPMC Univ Paris 6, CNRS, UMR 7144, Department, Adaptation & Diversity in Marine Environment, Divco Team, Station Biologique de Roscoff, Place Georges Teissier, 29680 Roscoff, France; Marine Environment Research Group, Ryan Institute, National University of Ireland Galway, Galway, Ireland. Electronic address: jmurphy@sb-roscoff.fr.
[Ti] Título:A modelling approach to explore the critical environmental parameters influencing the growth and establishment of the invasive seaweed Undaria pinnatifida in Europe.
[So] Source:J Theor Biol;396:105-15, 2016 May 07.
[Is] ISSN:1095-8541
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A key factor to determine the expansion dynamics and future distribution of non-native species is their physiological response to abiotic factors and their changes over time. For this study we developed a spatially explicit, agent-based model of population growth to represent the complex population dynamics of invasive marine macroalgae with heteromorphic biphasic life cycles. The model framework represents this complex life cycle by treating the individual developmental stages (gametophytes/sporophytes) as autonomous agents with unique behaviour/growth parameters. It was parameterised to represent a well-documented invasive algal species, the Asian kelp Undaria pinnatifida, and validated against field results from an in situ population in Brittany, France, showing good quantitative agreement in terms of seasonal changes in abundance/recruitment and growth dynamics. It was then used to explore how local environmental parameters (light availability, temperature and day length) affect the population dynamics of the individual developmental stages and the overall population growth. This type of modelling approach represents a promising tool for understanding the population dynamics of macroalgae from the bottom-up in terms of the individual interactions between the independent life history stages (both microscopic and macroscopic). It can be used to trace back the behaviour of the population as a whole to the underlying physiological and environmental processes impacting each developmental stage and give insights into the roles these play in invasion success.
[Mh] Termos MeSH primário: Ecossistema
Espécies Introduzidas
Modelos Biológicos
Undaria/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Europa (Continente)
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160211
[St] Status:MEDLINE


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[PMID]:26829364
[Au] Autor:Min SK; Han SM; Jang JS; Kim JK
[Ad] Endereço:aDepartment of Radiology bDepartment of Anatomy, School of Medicine, Catholic University of Daegu cDepartment of Thoracic and Cardiovascular Surgery, Samsung Medical Centre, School of Medicine, Sungkyunkwan University, Seoul dDepartment of Biomedical Engineering and Radiology, School of Medicine, Catholic University of Daegu, Daegu, Korea (Republic of).
[Ti] Título:Stimulatory effect of an algal fucoidan on the release of vascular endothelial tissue-type plasminogen activator as a mechanism of fucoidan-mediated thrombolysis.
[So] Source:Blood Coagul Fibrinolysis;27(5):594-6, 2016 Jul.
[Is] ISSN:1473-5733
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Identifying a pharmacological means for increasing the production of tissue-type plasminogen activator (t-PA) is always desirable to cure impaired production of this enzyme. An algal fucoidan has been shown to exhibit both novel thrombolytic and synergistic stimulatory effects in a mouse thrombosis model. The plasma levels of active t-PA were measured in mouse arterial thrombus models that were treated with various fucoidans to investigate the mechanism of thrombolysis. The mean plasma level of active t-PA after the infusion of fucoidan was 2.136 ±â€Š0.231 ng/ml for nonthrombolytic Fucus fucoidan and 3.917 ±â€Š0.0.529 ng/ml for thrombolytic Undaria fucoidan, which resulted in a 1.56-2.29-fold increase compared with the healthy control group (1.706 ±â€Š0.194 ng/ml) and the untreated thrombus group (2.506 ±â€Š0.301 ng/ml) (P < 0.01). An algal fucoidan has demonstrated to exert a thrombolytic and stimulatory effect via the induction of t-PA release in a dose-dependent manner in an arterial thrombosis model.
[Mh] Termos MeSH primário: Fibrinolíticos/farmacologia
Feófitas/química
Polissacarídeos/farmacologia
Trombose/tratamento farmacológico
Ativador de Plasminogênio Tecidual/biossíntese
Undaria/química
[Mh] Termos MeSH secundário: Animais
Artérias Carótidas/efeitos dos fármacos
Artérias Carótidas/metabolismo
Artérias Carótidas/patologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Endotélio Vascular/efeitos dos fármacos
Endotélio Vascular/metabolismo
Endotélio Vascular/patologia
Fibrinólise/efeitos dos fármacos
Fibrinolíticos/isolamento & purificação
Camundongos
Camundongos Endogâmicos BALB C
Polissacarídeos/isolamento & purificação
Terapia Trombolítica
Trombose/sangue
Trombose/patologia
Ativador de Plasminogênio Tecidual/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fibrinolytic Agents); 0 (Polysaccharides); 9072-19-9 (fucoidan); EC 3.4.21.68 (Tissue Plasminogen Activator)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160202
[St] Status:MEDLINE
[do] DOI:10.1097/MBC.0000000000000522



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