Base de dados : MEDLINE
Pesquisa : B03.280.100.150 [Categoria DeCS]
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  1 / 12 MEDLINE  
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[PMID]:24937366
[Au] Autor:Bui TH; Wray V; Nimtz M; Fossen T; Preisitsch M; Schröder G; Wende K; Heiden SE; Mundt S
[Ad] Endereço:Institute of Pharmacy, Department of Pharmaceutical Biology, Ernst-Moritz-Arndt-University , Friedrich-Ludwig-Jahn-Straße 17, D-17489 Greifswald, Germany.
[Ti] Título:Balticidins A-D, antifungal hassallidin-like lipopeptides from the Baltic Sea cyanobacterium Anabaena cylindrica Bio33.
[So] Source:J Nat Prod;77(6):1287-96, 2014 Jun 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Balticidins A-D (1-4), four new antifungal lipopeptides, were isolated from the laboratory-cultivated cyanobacterium Anabaena cylindrica strain Bio33 isolated from a water sample collected from the Baltic Sea, Rügen Island, Germany. Fractionation of the 50% aqueous MeOH extract was performed by bioassay-guided silica gel column chromatography followed by SPE and repeated reversed-phase HPLC. The main fraction containing the compounds exhibited a strong and specific antifungal activity with inhibition zones in an agar-diffusion assay from 21 to 32 mm against Candida albicans, Candida krusei, Candida maltosa, Aspergillus fumigatus, Microsporum gypseum, Mucor sp., and Microsporum canis. The structures were elucidated by multidimensional (1)H and (13)C NMR spectroscopy, HRESIMS, amino acid analysis, and sugar analysis. Spectroscopic data analysis afforded an unambiguous sequence of R.CHO(S1).CHOH.CONH-Thr(1)-Thr(2)-Thr(3)-HOTyr(4)-Dhb(5)-D-Gln(6)-Gly(7)-NMeThr(8)(S2)-L-Gln COOH(9), in which Dhb is dehydroaminobutyric acid, S1 is d(-)-arabinose-(3-1)-D-(+)-galacturonic acid, S2 is D-(+)-mannose, and R is the aliphatic residue -C13H26Cl or -C13H27. Besides NMeThr, D-allo-Thr, D-Thr, and L-Thr were identified, but the position of the enantiomers in the sequence is not clear. The four balticidins differ in their cyclic (2, 4)/linear (1, 3) core and the presence (1, 2)/absence (3, 4) of chlorine in the aliphatic unit.
[Mh] Termos MeSH primário: Anabaena cylindrica/química
Antifúngicos/isolamento & purificação
Lipopeptídeos/isolamento & purificação
Peptídeos Cíclicos/isolamento & purificação
[Mh] Termos MeSH secundário: Antifúngicos/química
Antifúngicos/farmacologia
Aspergillus fumigatus/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Cianobactérias/química
Alemanha
Lipopeptídeos/química
Lipopeptídeos/farmacologia
Testes de Sensibilidade Microbiana
Microsporum/efeitos dos fármacos
Estrutura Molecular
Mucor/efeitos dos fármacos
Ressonância Magnética Nuclear Biomolecular
Oceanos e Mares
Peptídeos Cíclicos/química
Peptídeos Cíclicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Lipopeptides); 0 (Peptides, Cyclic); 0 (balticidin A)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:150806
[Lr] Data última revisão:
150806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140618
[St] Status:MEDLINE
[do] DOI:10.1021/np401020a


  2 / 12 MEDLINE  
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[PMID]:24695147
[Au] Autor:Heng RL; Lee E; Pilon L
[Ti] Título:Radiation characteristics and optical properties of filamentous cyanobacterium Anabaena cylindrica.
[So] Source:J Opt Soc Am A Opt Image Sci Vis;31(4):836-45, 2014 Apr 01.
[Is] ISSN:1520-8532
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study presents experimental measurements of the absorption and scattering cross sections and the spectral complex index of refraction of filamentous cyanobacteria. Filamentous heterocystous cyanobacterium Anabaena cylindrica was chosen as a model organism. Its filaments consisted of long chains of polydisperse cells. Their average mass scattering and absorption cross sections were measured from 400 to 750 nm at four different times during their batch growth in medium BG-11(-N) under 3000 lux of white fluorescent light. The effective real (or refraction index) and imaginary (or absorption index) parts of the complex index of refraction were retrieved using an inverse method based on a genetic algorithm. The microorganisms were modeled as infinitely long and randomly oriented volume-equivalent cylinders. The absorption index featured peaks corresponding to chlorophyll a (Chl a) at 436 and 676 nm and phycocyanin (PCCN) at 630 nm and a shoulder around 480 nm, corresponding to photoprotective carotenoids. The absorption peaks of Chl a and PCCN concentrations increased and the shoulder due to carotenoids decreased in response to photolimitation caused by biomass growth. Subsequent nitrogen limitation caused the PCCN absorption peak to decrease significantly due to degradation of PCCN as an endogenous source of nitrogen for nitrogenase maintenance and synthesis, as confirmed by increasing heterocyst differentiation. The results can be used for predicting and optimizing light transfer in photobioreactors for wastewater treatment and ammonia or biofuel production.
[Mh] Termos MeSH primário: Anabaena cylindrica/metabolismo
Luz
Fenômenos Ópticos
[Mh] Termos MeSH secundário: Absorção
Fotossíntese
Espalhamento de Radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1412
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140404
[St] Status:MEDLINE
[do] DOI:10.1364/JOSAA.31.000836


  3 / 12 MEDLINE  
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[PMID]:20549627
[Au] Autor:Galhano V; Peixoto F; Gomes-Laranjo J
[Ad] Endereço:Department of Biology and Environment/Centre for Research and Technology of Agro-Environment and Biological Sciences, University of Trás-os-Montes and Alto Douro, Apartado 1013 - 5001-801 Vila Real, Portugal. vgalhano@utad.pt
[Ti] Título:Bentazon triggers the promotion of oxidative damage in the Portuguese ricefield cyanobacterium Anabaena cylindrica: response of the antioxidant system.
[So] Source:Environ Toxicol;25(5):517-26, 2010 Oct.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rice fields are frequently exposed to environmental contamination by herbicides and cyanobacteria, as primary producers of these aquatic ecosystems, are adversely affected. Anabaena cylindrica is a cyanobacterium with a significantly widespread occurrence in Portuguese rice fields. This strain was studied throughout 72 h in laboratory conditions for its stress responses to sublethal concentrations (0.75-2 mM) of bentazon, a selective postemergence herbicide recommended for integrated weed management in rice, with special reference to oxidative stress, role of proline and intracellular antioxidant enzymes in herbicide-induced free radicals detoxification. Activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and glutathione S-transferase (GST) increased in a time- and herbicide dose-response manner and were higher than those in the control samples after 72 h. A time- and concentration-dependent increase of malondialdehyde (MDA) levels and the enhanced cell membrane leakage following bentazon exposure are indicative of lipid peroxidation, free radicals formation, and oxidative damage, while increased amounts of SOD, CAT, APX, GST, and proline indicated their involvement in free radical scavenging mechanisms. The appreciable decline in the reduced glutathione (GSH) pool after 72 h at higher bentazon concentrations could be explained by the reduction of the NADPH-dependent glutathione reductase (GR) activity. The obtained results suggested that the alterations of antioxidant systems in A. cylindrica might be useful biomarkers of bentazon exposure. As the toxic mechanism of bentazon is a complex phenomenon, this study also adds relevant findings to explain the oxidative stress pathways of bentazon promoting oxidative stress in cyanobacteria.
[Mh] Termos MeSH primário: Anabaena cylindrica/efeitos dos fármacos
Antioxidantes/farmacologia
Benzotiadiazinas/toxicidade
Herbicidas/toxicidade
Oryza/efeitos dos fármacos
Poluentes do Solo/toxicidade
[Mh] Termos MeSH secundário: Anabaena cylindrica/crescimento & desenvolvimento
Anabaena cylindrica/metabolismo
Biomarcadores/análise
Biomarcadores/metabolismo
Relação Dose-Resposta a Droga
Radicais Livres/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Peroxidação de Lipídeos/fisiologia
Oryza/crescimento & desenvolvimento
Oryza/metabolismo
Oryza/microbiologia
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Portugal
Prolina/farmacologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzothiadiazines); 0 (Biomarkers); 0 (Free Radicals); 0 (Herbicides); 0 (Soil Pollutants); 9DLQ4CIU6V (Proline); R4S7ZGZ9CT (bentazone)
[Em] Mês de entrada:1012
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100616
[St] Status:MEDLINE
[do] DOI:10.1002/tox.20597


  4 / 12 MEDLINE  
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[PMID]:20187402
[Au] Autor:Peng ZE; Yang HZ; Wang BB; Deng NS
[Ad] Endereço:College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China. zhepeng66@gmail.com
[Ti] Título:[Study on the sorption of 4-octylphenol by freshwater algae].
[So] Source:Huan Jing Ke Xue;30(12):3652-7, 2009 Dec.
[Is] ISSN:0250-3301
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:The sorption of 4-octylphenol (4-OP) by two freshwater algae was investigated. Results showed that the sorption of 4-octylphenol by algae was obvious and quick, where 20% of initial 4-OP (2 mg/L) was accumulated by Chlorella vulgaris (CV) and 46% initial 4-OP (2 mg/L) was accumulated by Anabaena cylindrical (AC) after 5 min incubation. The sorption got equilibrium at 1 h after incubation. Langmuir sorption model was good appropriate type for this sorption. The effect of pH value on CV sorption was obvious than that on AC sorption. The sorption capacity of the biomass of two algae increased with the decrease of pH value. The analyzing of interaction between algae and 4-octylphenol was performed by fluorescence spectrum. Results showed that the algae could weaker the fluorescence spectrum intensity of 4-octylphenol and result in red shift of the maximum absorbance wavelength of mixture solution. Based on the results, it was speculated that algae bound with the contamination could use the near UV region of solar radiation and induced the contamination degradation.
[Mh] Termos MeSH primário: Anabaena cylindrica/química
Chlorella/química
Água Doce/análise
Fenóis/isolamento & purificação
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Anabaena cylindrica/metabolismo
Biodegradação Ambiental
Chlorella/metabolismo
Fenóis/metabolismo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Phenols); 7DF2B8LH3P (4-octylphenol)
[Em] Mês de entrada:1012
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100302
[St] Status:MEDLINE


  5 / 12 MEDLINE  
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[PMID]:19387863
[Au] Autor:Olsson-Francis K; de la Torre R; Towner MC; Cockell CS
[Ad] Endereço:Centre for Earth, Planetary, Space and Astronomical Research, The Open University, Walton Hall, Milton Keynes, UK. k.olsson@open.ac.uk
[Ti] Título:Survival of akinetes (resting-state cells of cyanobacteria) in low earth orbit and simulated extraterrestrial conditions.
[So] Source:Orig Life Evol Biosph;39(6):565-79, 2009 Dec.
[Is] ISSN:1573-0875
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cyanobacteria are photosynthetic organisms that have been considered for space applications, such as oxygen production in bioregenerative life support systems, and can be used as a model organism for understanding microbial survival in space. Akinetes are resting-state cells of cyanobacteria that are produced by certain genera of heterocystous cyanobacteria to survive extreme environmental conditions. Although they are similar in nature to endospores, there have been no investigations into the survival of akinetes in extraterrestrial environments. The aim of this work was to examine the survival of akinetes from Anabaena cylindrica in simulated extraterrestrial conditions and in Low Earth Orbit (LEO). Akinetes were dried onto limestone rocks and sent into LEO for 10 days on the ESA Biopan VI. In ground-based experiments, the rocks were exposed to periods of desiccation, vacuum (0.7×10(-3) kPa), temperature extremes (-80 to 80°C), Mars conditions (-27°C, 0.8 kPa, CO(2)) and UV radiation (325-400 nm). A proportion of the akinete population was able to survive a period of 10 days in LEO and 28 days in Mars simulated conditions, when the rocks were not subjected to UV radiation. Furthermore, the akinetes were able to survive 28 days of exposure to desiccation and low temperature with high viability remaining. Yet long periods of vacuum and high temperature were lethal to the akinetes. This work shows that akinetes are extreme-tolerating states of cyanobacteria that have a practical use in space applications and yield new insight into the survival of microbial resting-state cells in space conditions.
[Mh] Termos MeSH primário: Viabilidade Microbiana
Esporos Bacterianos/fisiologia
[Mh] Termos MeSH secundário: Anabaena cylindrica/fisiologia
Temperatura Baixa
Dessecação
Meio Ambiente Extraterreno
Temperatura Alta
Astronave
Raios Ultravioleta
Vácuo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1108
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:090424
[St] Status:MEDLINE
[do] DOI:10.1007/s11084-009-9167-4


  6 / 12 MEDLINE  
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[PMID]:18375140
[Au] Autor:Deng L; Wu F; Deng N; Zuo Y
[Ad] Endereço:Department of Municipal Engineering, Southeast University, Nanjing 210096, PR China. dlwhu@163.com
[Ti] Título:Photoreduction of mercury(II) in the presence of algae, Anabaena cylindrical.
[So] Source:J Photochem Photobiol B;91(2-3):117-24, 2008 May 29.
[Is] ISSN:1011-1344
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The photochemical and biological reduction of Hg(II) in the presence of algae, anabaena cylindrical, was investigated under the irradiation of metal halide lamps placed in cooling trap for maintaining constant temperature by water circulation (lambda >or=365 nm, 250 W). The photoreduction rate of Hg(II) increased with increasing algae concentration. The addition of Fe(III) and humic substances into the suspensions of algae also enhanced the photoreduction of Hg(II). Alteration of pH value affected the photoreduction of Hg(II) in aqueous solution with or without the addition of algae. The concentration of dissolved gaseous mercury (DGM), the reduced product of Hg(II), increased with increasing exposure time and then gradually approached to a steady state. The influence of initial Hg(II) concentration on the photoreduction of Hg(II) with algae was studied by irradiating the suspensions of anabaena cylindrical at pH 7.0 with initial concentrations (C(0)) of Hg(II) at 50, 100, 120, 150 and 180 microg L(-1), respectively, the light-induced reduction of Hg(II) followed the apparent pseudo first-order kinetics. The initial photoreduction rate could be expressed by the equation: r(A)=0.0871+0.00129 C(0), with a correlation coefficient R=0.9994. The overall mercury mass balance study on the photo-reductive process revealed that more than 39.86% of Hg(II) from the algal suspension was reduced to volatile metallic mercury.
[Mh] Termos MeSH primário: Anabaena cylindrica/metabolismo
Eucariotos/metabolismo
Mercúrio/química
Mercúrio/metabolismo
[Mh] Termos MeSH secundário: Água Doce/microbiologia
Gases/química
Substâncias Húmicas
Concentração de Íons de Hidrogênio
Ferro/farmacologia
Iluminação
Oxirredução/efeitos dos fármacos
Fotoquímica
Luz Solar
Suspensões/química
Temperatura Ambiente
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gases); 0 (Humic Substances); 0 (Suspensions); 059QF0KO0R (Water); E1UOL152H7 (Iron); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:0810
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080401
[St] Status:MEDLINE
[do] DOI:10.1016/j.jphotobiol.2008.02.005


  7 / 12 MEDLINE  
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[PMID]:18198493
[Au] Autor:Lukowski G; Lindequist U; Mundt S; Kramer A; Julich WD
[Ad] Endereço:Institute of Marine Biotechnology e.V., Greifswald, Germany. lukowski@uni-greifswald.de
[Ti] Título:Inhibition of dermal MRSA colonization by microalgal micro- and nanoparticles.
[So] Source:Skin Pharmacol Physiol;21(2):98-105, 2008.
[Is] ISSN:1660-5535
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate the prevention of the dermal colonization of methicillin-resistant Staphylococcus aureus (MRSA) strains by the application of micro- and nanoparticles called Maresometrade mark. Maresometrade mark were prepared from selected microalgae by a novel emulsion technique. They contain lipids and all other components of the microalgae in an encapsulated form. It could be shown that Maresometrade mark prepared from a cyanobacterial strain of the order Nostocales (Bio33-Maresometrade mark) were able to inhibit the dermal colonization of different MRSA strains (North German Epidemic Strain, Col, N315) and even of the vancomycin-resistant strain MU50 in the models 'mouse ear' and 'cow udder teat'. Pretreatment of the skin with Maresometrade mark reduced the number of attached MRSA by 3-4 log units in comparison to the control. We assume that a prophylactic skin care with Maresometrade mark could complete the multibarrier anti-infectious strategy against MRSA.
[Mh] Termos MeSH primário: Anabaena cylindrica
Resistência a Meticilina
Pele/microbiologia
Staphylococcus aureus/fisiologia
[Mh] Termos MeSH secundário: Animais
Bovinos
Portadores de Fármacos
Composição de Medicamentos
Orelha Externa
Ácidos Graxos/análise
Feminino
Glândulas Mamárias Animais
Camundongos
Camundongos Endogâmicos BALB C
Nanopartículas
Staphylococcus aureus/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Fatty Acids)
[Em] Mês de entrada:0806
[Cu] Atualização por classe:080325
[Lr] Data última revisão:
080325
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080117
[St] Status:MEDLINE
[do] DOI:10.1159/000113066


  8 / 12 MEDLINE  
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[PMID]:18051295
[Au] Autor:Kim JD; Lee CG
[Ad] Endereço:Institute of Industrial Biotechnology, Department of Biological Engineering, Inha University, Incheon 402-751, Korea.
[Ti] Título:Purification and characterization of extracellular beta-glucosidase from Sinorhizobium kostiense AFK-13 and its algal lytic effect on Anabaena flos-aquae.
[So] Source:J Microbiol Biotechnol;17(5):745-52, 2007 May.
[Is] ISSN:1017-7825
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:A beta-glucosidase from the algal lytic bacterium Sinorhizobium kostiense AFK-13, grown in complex media containing cellobiose, was purified to homogeneity by successive ammonium sulfate precipitation, and anion-exchange and gel-filtration chromatographies. The enzyme was shown to be a monomeric protein with an apparent molecular mass of 52 kDa and isoelectric point of approximately 5.4. It was optimally active at pH 6.0 and 40'C and possessed a specific activity of 260.4 U/mg of protein against 4-nitrophenyl-beta-D-glucopyranoside (pNPG). A temperature-stability analysis demonstrated that the enzyme was unstable at 50 degrees C and above. The enzyme did not require divalent cations for activity, and its activity was significantly suppressed by Hg+2 and Ag+, whereas sodium dodecyl sulfate (SDS) and Triton X-100 moderately inhibited the enzyme to under 70% of its initial activity. In an algal lytic activity analysis, the growth of cyanobacteria, such as Anabaena flos-aquae, A. cylindrica, A. macrospora, Oscillatoria sancta, and Microcystis aeruginosa, was strongly inhibited by a treatment of 20 ppm/disc or 30 ppm/disc concentration of the enzyme.
[Mh] Termos MeSH primário: Anabaena flos-aquae/efeitos dos fármacos
Antibacterianos/isolamento & purificação
Antibacterianos/metabolismo
Sinorhizobium/enzimologia
beta-Glucosidase/isolamento & purificação
beta-Glucosidase/metabolismo
[Mh] Termos MeSH secundário: Sulfato de Amônio/metabolismo
Anabaena cylindrica/efeitos dos fármacos
Anabaena cylindrica/crescimento & desenvolvimento
Anabaena flos-aquae/crescimento & desenvolvimento
Fracionamento Químico
Cromatografia em Gel
Cromatografia por Troca Iônica
Inibidores Enzimáticos/farmacologia
Estabilidade Enzimática
Glucosídeos/metabolismo
Ouro/farmacologia
Concentração de Íons de Hidrogênio
Ponto Isoelétrico
Mercúrio/farmacologia
Microcystis/efeitos dos fármacos
Microcystis/crescimento & desenvolvimento
Peso Molecular
Octoxinol/farmacologia
Oscillatoria/efeitos dos fármacos
Oscillatoria/crescimento & desenvolvimento
Dodecilsulfato de Sódio/farmacologia
Temperatura Ambiente
beta-Glucosidase/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RETRACTED PUBLICATION
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Enzyme Inhibitors); 0 (Glucosides); 2492-87-7 (4-nitrophenyl beta-D-glucoside); 368GB5141J (Sodium Dodecyl Sulfate); 7440-57-5 (Gold); 9002-93-1 (Octoxynol); EC 3.2.1.21 (beta-Glucosidase); FXS1BY2PGL (Mercury); SU46BAM238 (Ammonium Sulfate)
[Em] Mês de entrada:0801
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:071207
[St] Status:MEDLINE


  9 / 12 MEDLINE  
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[PMID]:17902695
[Au] Autor:Gademann K; Bethuel Y; Locher HH; Hubschwerlen C
[Ad] Endereço:Chemical Synthesis Laboratory, Swiss Federal Institute of Technology (EPFL), SB-ISIC-LSYNC, CH-1015 Lausanne, Switzerland. karl.gademann@epfl.ch
[Ti] Título:Biomimetic total synthesis and antimicrobial evaluation of anachelin H.
[So] Source:J Org Chem;72(22):8361-70, 2007 Oct 26.
[Is] ISSN:0022-3263
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The first biomimetic total synthesis of the iron chelator anachelin H isolated from the cyanobacterium Anabaena cylindrica is reported. A first generation approach delivered one enantiomeric series of the polyketide fragment. Comparison of the 1H NMR data suggested the relative configuration of this anachelin fragment. The relative and absolute configuration of anachelin H was then established by total synthesis. A second generation approach involved the enzymatic conversion of N,N-dimethyltyramine to the anachelin chromophore. It was demonstrated that the enzyme tyrosinase is activated by the product during this reaction, the anachelin chromophore can serve as a tyrosinase activator. Anachelin H was evaluated against a panel of eleven bacterial and fungal pathogens, and moderate antibiotic activity (32 microg/mL) against Moraxella catarrhalis was found.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Antibacterianos/farmacologia
Antifúngicos/síntese química
Antifúngicos/farmacologia
Moraxella (Branhamella) catarrhalis/efeitos dos fármacos
Oligopeptídeos/síntese química
Oligopeptídeos/farmacologia
Compostos de Quinolínio/síntese química
Compostos de Quinolínio/farmacologia
Saccharomyces cerevisiae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anabaena cylindrica/química
Antibacterianos/química
Antifúngicos/química
Biomimética
Testes de Sensibilidade Microbiana
Conformação Molecular
Oligopeptídeos/química
Compostos de Quinolínio/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Oligopeptides); 0 (Quinolinium Compounds); 0 (anachelin H)
[Em] Mês de entrada:0801
[Cu] Atualização por classe:071019
[Lr] Data última revisão:
071019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:071002
[St] Status:MEDLINE


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[PMID]:17849161
[Au] Autor:Bhadauriya P; Gupta R; Singh S; Bisen PS
[Ad] Endereço:Department of Biotechnology, Madhav Institute of Technology & Science, Race Course Road, 474001, Gwalior, India.
[Ti] Título:Physiological and biochemical alterations in a diazotrophic cyanobacterium Anabaena cylindrica under NaCl stress.
[So] Source:Curr Microbiol;55(4):334-8, 2007 Oct.
[Is] ISSN:0343-8651
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Growth, morphological variation, and liquid chromatography-photodiode array detection-mass spectrometric analysis of pigments have been studied in a diazotrophic cyanobacterium Anabaena cylindrica in response to NaCl stress. The chlorophyll and cellular protein contents increased initially in response to 50 mM: NaCl. Further increment in NaCl concentration, however, resulted in a significant decrease in both chlorophyll and cellular protein. A. cylindrica cells subjected to NaCl stress also showed morphological variations by having alteration in their size and volume. A. cylindrica cells subjected to NaCl stress also exhibited altered plastoquinone and chlorophyll-a (chl a) levels in comparison to its NaCl-untreated counterpart. Furthermore, a relative increase in plastoquinone level and a subsequent decrease in chl a level were recorded in NaCl adapted cells of A. cylindrica in response to NaCl stress. These results suggest that owing to adaptation various morphological, physiological, and biochemical changes occur in the cyanobacterium A. cylindrica in response to NaCl stress.
[Mh] Termos MeSH primário: Anabaena cylindrica/química
Anabaena cylindrica/fisiologia
Cloreto de Sódio/farmacologia
[Mh] Termos MeSH secundário: Anabaena cylindrica/ultraestrutura
Proteínas de Bactérias/análise
Proteínas de Bactérias/metabolismo
Clorofila/análise
Clorofila/metabolismo
Cromatografia Líquida
Espectrometria de Massas
Microscopia Eletrônica de Varredura
Fixação de Nitrogênio
Plastoquinona/análise
Plastoquinona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 1406-65-1 (Chlorophyll); 451W47IQ8X (Sodium Chloride); OAC30J69CN (Plastoquinone); YF5Q9EJC8Y (chlorophyll a)
[Em] Mês de entrada:0712
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070913
[St] Status:MEDLINE



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