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  1 / 16 MEDLINE  
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[PMID]:29217301
[Au] Autor:Bruneau A; Baylatry MT; Joly AC; Sokol H
[Ad] Endereço:AP-HP, hôpital Saint-Antoine, pharmacie hospitaliere, 184, rue du faubourg Saint-Antoine, 75012 Paris, France.
[Ti] Título:[Gut microbiota: What impact on colorectal carcinogenesis and treatment?]
[Ti] Título:Le microbiote intestinal : quels impacts sur la carcinogenèse et le traitement du cancer colorectal ?.
[So] Source:Bull Cancer;105(1):70-80, 2018 Jan.
[Is] ISSN:1769-6917
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The gut microbiota, composed of 10 microorganisms, is now considered as a "hidden organ", regarding to its digestive, metabolic and immune functions, which are helpful to its host. For the last 15 years, advances in molecular biology have highlighted the association of gut microbiota dysbiosis with several diseases, including colorectal cancer. An increased abundance of some bacteria (including Fusobacterium nucleatum, Bacteroides fragilis, Escherichia coli) is associated with cancer, whereas others seem to be protective (Faecalibacterium prausnitzii). Several mechanisms, which are species-specific, are involved in colorectal carcinogenesis. Most of the time, bacterial toxins are involved in pro-inflammatory processes and in activation of angiogenesis and cellular proliferation pathways. The identification of these bacteria leads to envisage the gut microbiota as potential screening tool for colorectal cancer. Recent studies showed a relation between the gut microbiota and the efficacy and toxicity of chemotherapies (oxaliplatin, irinotecan) and immunotherapies (including ipilimumab). Therapeutic approaches targeting the gut microbiota are now available (probiotics, fecal microbiota transplantation…). New therapeutic strategy combining both chemotherapy and/or immunotherapy with an adjuvant treatment targeting the gut microbiota can now be developed in order to improve treatment response and tolerance.
[Mh] Termos MeSH primário: Neoplasias Colorretais/microbiologia
Neoplasias Colorretais/terapia
Microbioma Gastrointestinal
[Mh] Termos MeSH secundário: Toxinas Bacterianas/metabolismo
Bacteroides fragilis
Proliferação Celular
Resistência a Medicamentos Antineoplásicos
Disbiose/induzido quimicamente
Disbiose/complicações
Enterococcus faecalis
Escherichia coli
Faecalibacterium prausnitzii
Transplante de Microbiota Fecal
Fusobacterium nucleatum
Microbioma Gastrointestinal/fisiologia
Seres Humanos
Neovascularização Patológica/microbiologia
Probióticos/uso terapêutico
Streptococcus gallolyticus
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Bacterial Toxins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


  2 / 16 MEDLINE  
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[PMID]:28187199
[Au] Autor:Bressa C; Bailén-Andrino M; Pérez-Santiago J; González-Soltero R; Pérez M; Montalvo-Lominchar MG; Maté-Muñoz JL; Domínguez R; Moreno D; Larrosa M
[Ad] Endereço:Department of Basic Sciences, European University, Madrid, Spain.
[Ti] Título:Differences in gut microbiota profile between women with active lifestyle and sedentary women.
[So] Source:PLoS One;12(2):e0171352, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Physical exercise is a tool to prevent and treat some of the chronic diseases affecting the world's population. A mechanism through which exercise could exert beneficial effects in the body is by provoking alterations to the gut microbiota, an environmental factor that in recent years has been associated with numerous chronic diseases. Here we show that physical exercise performed by women to at least the degree recommended by the World Health Organization can modify the composition of gut microbiota. Using high-throughput sequencing of the 16s rRNA gene, eleven genera were found to be significantly different between active and sedentary women. Quantitative PCR analysis revealed higher abundance of health-promoting bacterial species in active women, including Faecalibacterium prausnitzii, Roseburia hominis and Akkermansia muciniphila. Moreover, body fat percentage, muscular mass and physical activity significantly correlated with several bacterial populations. In summary, we provide the first demonstration of interdependence between some bacterial genera and sedentary behavior parameters, and show that not only does the dose and type of exercise influence the composition of gut microbiota, but also the breaking of sedentary behavior.
[Mh] Termos MeSH primário: Exercício
Microbioma Gastrointestinal
Estilo de Vida Sedentário
[Mh] Termos MeSH secundário: Adulto
Distribuição da Gordura Corporal
Clostridiales/isolamento & purificação
Faecalibacterium prausnitzii/isolamento & purificação
Feminino
Seres Humanos
Verrucomicrobia/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171352


  3 / 16 MEDLINE  
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[PMID]:28125651
[Au] Autor:Jeffery ND; Barker AK; Alcott CJ; Levine JM; Meren I; Wengert J; Jergens AE; Suchodolski JS
[Ad] Endereço:Department of Veterinary Clinical Studies, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United State of America.
[Ti] Título:The Association of Specific Constituents of the Fecal Microbiota with Immune-Mediated Brain Disease in Dogs.
[So] Source:PLoS One;12(1):e0170589, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Meningoencephalomyelitis of unknown origin (MUO) is a common, naturally-occurring, clinical disease of pet dogs. It is an immune-mediated condition that has many similarities with experimental autoimmune encephalitis (EAE) in rodents and so investigation of its pathogenesis may aid in understanding factors that contribute to development of multiple sclerosis in people. Gut microbiota are known to modulate immune responses that influence susceptibility to immune-mediated brain disease. In this study we aimed to compare abundance of specific constituents of the fecal microbiota, namely Faecalibacterium prausnitzii and Prevotellaceae, between dogs diagnosed with MUO and matched controls. Fecal samples were obtained from 20 dogs diagnosed with MUO and 20 control dogs matched for breed, age and gender. Bacterial abundance was measured using qPCR and 16S rRNA sequencing. We found that Prevotellaceae were significantly less abundant in cases compared with controls (p = 0.003) but there was no difference in abundance of F.prausnitzii. There was no evidence of other differences in gut microbiota between groups. These data, derived from this naturally-occurring canine clinical model, provide strong corroborative evidence that high abundance of Prevotellaceae in the gut is associated with reduced risk for developing immune-mediated brain disease.
[Mh] Termos MeSH primário: Bacteroidetes/isolamento & purificação
Encefalopatias/microbiologia
Doenças do Cão/microbiologia
Microbiota/genética
[Mh] Termos MeSH secundário: Animais
Bacteroidetes/genética
Bacteroidetes/patogenicidade
Encefalopatias/diagnóstico
Encefalopatias/genética
Encefalopatias/patologia
DNA Bacteriano/genética
Doenças do Cão/diagnóstico
Doenças do Cão/genética
Doenças do Cão/patologia
Cães
Faecalibacterium prausnitzii/genética
Faecalibacterium prausnitzii/isolamento & purificação
Faecalibacterium prausnitzii/patogenicidade
Fezes/microbiologia
Trato Gastrointestinal/microbiologia
RNA Ribossômico 16S/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170589


  4 / 16 MEDLINE  
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[PMID]:28045459
[Au] Autor:Lopez-Siles M; Duncan SH; Garcia-Gil LJ; Martinez-Medina M
[Ad] Endereço:Laboratori de Microbiologia Molecular, Departament de Biologia, Universitat de Girona, Girona, Spain.
[Ti] Título:Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics.
[So] Source:ISME J;11(4):841-852, 2017 Apr.
[Is] ISSN:1751-7370
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There is an increasing interest in Faecalibacterium prausnitzii, one of the most abundant bacterial species found in the gut, given its potentially important role in promoting gut health. Although some studies have phenotypically characterized strains of this species, it remains a challenge to determine which factors have a key role in maintaining the abundance of this bacterium in the gut. Besides, phylogenetic analysis has shown that at least two different F. prausnitzii phylogroups can be found within this species and their distribution is different between healthy subjects and patients with gut disorders. It also remains unknown whether or not there are other phylogroups within this species, and also if other Faecalibacterium species exist. Finally, many studies have shown that F. prausnitzii abundance is reduced in different intestinal disorders. It has been proposed that F. prausnitzii monitoring may therefore serve as biomarker to assist in gut diseases diagnostics. In this mini-review, we aim to serve as an overview of F. prausnitzii phylogeny, ecophysiology and diversity. In addition, strategies to modulate the abundance of F. prausnitzii in the gut as well as its application as a biomarker for diagnostics and prognostics of gut diseases are discussed. This species may be a useful potential biomarker to assist in ulcerative colitis and Crohn's disease discrimination.
[Mh] Termos MeSH primário: Faecalibacterium prausnitzii/isolamento & purificação
[Mh] Termos MeSH secundário: Biomarcadores
Faecalibacterium prausnitzii/genética
Gastroenteropatias/microbiologia
Seres Humanos
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE
[do] DOI:10.1038/ismej.2016.176


  5 / 16 MEDLINE  
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[PMID]:27537603
[Au] Autor:Koga Y; Tokunaga S; Nagano J; Sato F; Konishi K; Tochio T; Murakami Y; Masumoto N; Tezuka JI; Sudo N; Kubo C; Shibata R
[Ad] Endereço:Laboratory for Infectious Diseases, Tokai University School of Medicine, Isehara, Japan.
[Ti] Título:Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants.
[So] Source:Pediatr Res;80(6):844-851, 2016 Dec.
[Is] ISSN:1530-0447
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although Faecalibacterium prausnitzii is a major bacterium in the intestine of adults, which is known to have anti-inflammatory effects, the development in infants or the response to prebiotics remains unclear. METHODS: The counts of F. prausnitzii in the feces were examined by real-time polymerase chain reaction (PCR). Fecal samples were obtained from 65 atopic dermatitis (AD) infants who participated in a randomized controlled clinical trial to investigate the therapeutic effect of kestose, the smallest fructooligosaccharide. RESULTS: Although the F. prausnitzii count was undetectable level in most 0- to 1-y-old infants, the count reached a level comparable to that in adults in 2- to 5-y-old infants. The bacterial number increased about 10-fold by oral administration of kestose every day for 12 wk in the younger infants, but not so much in the older infants. This bacterial increase was significantly correlated with an improvement in the AD symptoms in the older infants. CONCLUSION: The F. prausnitzii population in the intestine reaches a level comparable to that in adult at approximately 2 y of age. Kestose efficiently stimulates the growth of this bacterium in the intestine, which might lead to an improvement in AD symptoms in infants.
[Mh] Termos MeSH primário: Dermatite Atópica/tratamento farmacológico
Dermatite Atópica/microbiologia
Faecalibacterium prausnitzii/efeitos dos fármacos
Oligossacarídeos/uso terapêutico
Prebióticos/administração & dosagem
[Mh] Termos MeSH secundário: Fatores Etários
Carga Bacteriana
Bifidobacterium/efeitos dos fármacos
Bifidobacterium/genética
Bifidobacterium/isolamento & purificação
Pré-Escolar
Faecalibacterium prausnitzii/genética
Faecalibacterium prausnitzii/isolamento & purificação
Feminino
Microbioma Gastrointestinal/efeitos dos fármacos
Seres Humanos
Lactente
Recém-Nascido
Masculino
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Oligosaccharides); 0 (Prebiotics); 0 (fructooligosaccharide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE
[do] DOI:10.1038/pr.2016.167


  6 / 16 MEDLINE  
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[PMID]:27431681
[Au] Autor:Jiang S; Xie S; Lv D; Zhang Y; Deng J; Zeng L; Chen Y
[Ad] Endereço:Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Ministry of Education, Guangzhou, 510000, China.
[Ti] Título:A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression.
[So] Source:Antonie Van Leeuwenhoek;109(10):1389-96, 2016 Oct.
[Is] ISSN:1572-9699
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The human gut microbiota plays an important role in human health and might also be implicated in kidney disease. The interest in butyrate producing bacteria has recently increased and is a poorly understood faecal condition in chronic kidney disease (CKD). Therefore, we evaluated differences of the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii in the faeces of Chinese patients with CKD. A case-control study was carried out for 65 CKD patients and 20 healthy controls. Differences were quantitatively validated using quantitative real-time polymerase chain reaction (qPCR). Spearman rank correlation was used to analyse the correlation between gut microbiota and clinical variables. Roseburia spp. and F. prausnitzii were significantly different in CKD patients and controls (p = 0.001; p = 0.025, respectively) and reduced more markedly in end stage renal disease (p = 0.000; p = 0.003, respectively) and microinflammation (p = 0.004; p = 0.001, respectively). Roseburia spp. and F. prausnitzii were negatively associated with C-reactive protein in plasma (r = -0.493, p = 0.00; r = -0.528, p = 0.000; respectively) and Cystatin C (r = -0.321, p = 0.006; r = -0.445, p = 0.000; respectively). They were positively associated with eGFR (r = 0.347, p = 0.002; r = 0.416, p = 0.000; respectively). The negative correlation between Roseburia spp., F. prausnitzii and CRP and renal function suggested that the depletion of butyrate producing bacteria may contribute to CKD-associated inflammation and CKD progression. Roseburia spp. and F. prausnitzii may thus serve as 'microbiomarkers'.
[Mh] Termos MeSH primário: Butiratos/metabolismo
Clostridiales/metabolismo
Faecalibacterium prausnitzii/metabolismo
Insuficiência Renal Crônica/microbiologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Progressão da Doença
Fezes/microbiologia
Feminino
Microbioma Gastrointestinal
Seres Humanos
Masculino
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butyrates)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.1007/s10482-016-0737-y


  7 / 16 MEDLINE  
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[PMID]:27298563
[Au] Autor:Huang XL; Zhang X; Fei XY; Chen ZG; Hao YP; Zhang S; Zhang MM; Yu YQ; Yu CG
[Ad] Endereço:Xiao-Li Huang, Yan-Ping Hao, Yan-Qiu Yu, Cheng-Gong Yu, Department of Gastroenterology, Gulou School of Clinical Medicine, Nanjing Medical University, Nanjing 210008, Jiangsu Province, China.
[Ti] Título:Faecalibacterium prausnitzii supernatant ameliorates dextran sulfate sodium induced colitis by regulating Th17 cell differentiation.
[So] Source:World J Gastroenterol;22(22):5201-10, 2016 Jun 14.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: To explore the preventive and therapeutic effects of Faecalibacterium prausnitzii (F. prausnitzii) supernatant on dextran sulfate sodium (DSS) induced colitis in mice. METHODS: Forty C57BL/6J male mice were randomly divided into four groups: control group, model group, treatment group, and prevention group. Mice were weighed daily. On day 10, the colon length was measured, the colorectal histopathologic damage score (HDS) was assessed, and plasma interleukin (IL)-17A, IL-6, and IL-4 levels were detected by enzyme-linked immunosorbent assay. The expression of transcription factor retinoic acid-related orphan receptor-γt (RORγt) and IL-17A in colon inflammatory mucosa tissue were determined by immunohistochemical assay, and the expression levels of RORγt mRNA, IL-17A mRNA, and IL-6 mRNA were detected by real-time quantitative polymerase chain reaction (PCR). The proportion of Th17 in mononuclear cells in spleen was assayed by fluorescence activated cell sorter. RESULTS: When compared with the model group, the colon length (P < 0.05) and body weight (P < 0.01) in the treatment and prevention groups were significantly increased, and the colon HDS was decreased (P < 0.05 and P < 0.01). There was no statistical difference between the treatment group and prevention group. After treatment with F. prausnitzii supernatant, the plasma levels of IL-17A and IL-6 (P < 0.05), the protein and mRNA expression of IL-17A and RORγt, and the Th17 cell ratio of spleen cells (P < 0.01) were significantly decreased compared to the model group. Plasma IL-4 level in the prevention group was significantly higher than that in the model group (P < 0.05), but there was no significant difference between these two groups in the expression of IL-6 in both the plasma and colon mucosa tissues. CONCLUSION: F. prausnitzii supernatant exerts protective and therapeutic effects on DSS-induced colitis in mice, probably via inhibition of Th17 differentiation and IL-17A secretion in the plasma and colon mucosa tissues. It can also improve colitis in mice by downregulating IL-6 and prevent colitis by upregulating IL-4.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Colite/prevenção & controle
Colo/efeitos dos fármacos
Suplementos Nutricionais
Faecalibacterium prausnitzii/metabolismo
Fármacos Gastrointestinais/farmacologia
Células Th17/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Colite/sangue
Colite/induzido quimicamente
Colite/imunologia
Colo/imunologia
Colo/metabolismo
Colo/patologia
Sulfato de Dextrana
Mediadores da Inflamação/sangue
Interleucina-17/sangue
Interleucina-17/genética
Interleucina-4/sangue
Interleucina-6/sangue
Interleucina-6/genética
Masculino
Camundongos Endogâmicos C57BL
Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares/genética
Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Células Th17/imunologia
Células Th17/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Gastrointestinal Agents); 0 (Il17a protein, mouse); 0 (Inflammation Mediators); 0 (Interleukin-17); 0 (Interleukin-6); 0 (Nuclear Receptor Subfamily 1, Group F, Member 3); 0 (RNA, Messenger); 0 (Rorc protein, mouse); 0 (interleukin-6, mouse); 207137-56-2 (Interleukin-4); 9042-14-2 (Dextran Sulfate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v22.i22.5201


  8 / 16 MEDLINE  
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[PMID]:27286235
[Au] Autor:Stoll ML; Cron RQ
[Ad] Endereço:Division of Rheumatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
[Ti] Título:The microbiota in pediatric rheumatic disease: epiphenomenon or therapeutic target?
[So] Source:Curr Opin Rheumatol;28(5):537-43, 2016 Sep.
[Is] ISSN:1531-6963
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: There has been increasing interest in the contents and function of the microbiota, as it relates to pediatric inflammatory diseases. Here, we discuss the factors underlying the development of the microbiota, its role in juvenile idiopathic arthritis (JIA) and prospects for therapeutic interventions in the microbiota. RECENT FINDINGS: The human microbiota undergoes a succession of changes, until it reaches a mature form. A variety of early-life exposures, including mode of delivery and form of feeding, can affect the contents of the microbiota and possibly impact upon long-term risk of developing autoimmune diseases. The microbiota is altered in children with JIA, including elevated Bacteroides genus in JIA as a whole and decreased Faecalibacterium prausnitzii in pediatric spondyloarthritis. Although there are limited data so far indicating that microbiota-based therapies can result in therapeutic improvement of arthritis, most of the data are on adults and thus may not be applicable to children. SUMMARY: Perturbations of the microbiota during childhood may result in the development of a microbiota associated with increased risk of pediatric rheumatic illness. Whether the microbiota can be targeted is a focus of ongoing research.
[Mh] Termos MeSH primário: Artrite Juvenil/imunologia
Microbioma Gastrointestinal/imunologia
Espondiloartropatias/imunologia
[Mh] Termos MeSH secundário: Adolescente
Artrite Juvenil/microbiologia
Artrite Juvenil/terapia
Bacteroides
Criança
Dietoterapia
Faecalibacterium prausnitzii
Seres Humanos
Probióticos/uso terapêutico
Doenças Reumáticas/imunologia
Doenças Reumáticas/microbiologia
Doenças Reumáticas/terapia
Fatores de Risco
Espondiloartropatias/microbiologia
Espondiloartropatias/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE
[do] DOI:10.1097/BOR.0000000000000312


  9 / 16 MEDLINE  
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[PMID]:27233082
[Au] Autor:Moens F; Weckx S; De Vuyst L
[Ad] Endereço:Research Group of Industrial Microbiology and Food Biotechnology, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.
[Ti] Título:Bifidobacterial inulin-type fructan degradation capacity determines cross-feeding interactions between bifidobacteria and Faecalibacterium prausnitzii.
[So] Source:Int J Food Microbiol;231:76-85, 2016 Aug 16.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Prebiotic inulin-type fructans (ITF) display a bifidogenic and butyrogenic effect. Four bifidobacterial strains (Bifidobacterium breve Yakult, Bifidobacterium adolescentis LMG 10734, Bifidobacterium angulatum LMG 11039(T), and Bifidobacterium longum subsp. longum LMG 11047), displaying different ITF degradation capacities, were each grown in cocultivation with Faecalibacterium prausnitzii DSM 17677(T), an ITF-degrading butyrate-producing colon bacterium, as to unravel their cross-feeding interactions. These coculture fermentations were performed in a medium for colon bacteria, whether or not including acetate (necessary for the growth of F. prausnitzii DSM 17677(T) and whether or not provided through cross-feeding), supplemented with oligofructose or inulin as the sole energy source. Bifidobacterium breve Yakult did not degrade oligofructose, resulting in the production of high concentrations of butyrate by F. prausnitzii DSM 17677(T) through oligofructose degradation. The degradation of oligofructose by B. adolescentis LMG 10734 and of oligofructose and inulin by B. angulatum LMG 11039(T) and B. longum LMG 11047 resulted in the production of acetate, which was cross-fed to F. prausnitzii DSM 17677(T), enabling the latter strain to degrade oligofructose and inulin. Slow preferential degradation of the short chain length fractions of oligofructose (intracellularly) by B. adolescentis LMG 10734 enabled substantial oligofructose degradation by F. prausnitzii DSM 17677(T). However, fast non-preferential degradation of all chain length fractions of oligofructose (extracellularly) and efficient degradation of the short chain length fractions of inulin by B. angulatum LMG 11039(T) and B. longum LMG 11047 made it impossible for F. prausnitzii DSM 17677(T) to compete for the available substrate. These results indicate that cross-feeding interactions between bifidobacteria and acetate-depending, butyrate-producing colon bacteria can be either a pure commensal or beneficial relationship between these bacteria, or can be dominated by competition, depending on the ITF degradation capacities of the bifidobacterial strains involved.
[Mh] Termos MeSH primário: Bifidobacterium/metabolismo
Faecalibacterium prausnitzii/metabolismo
Microbiologia de Alimentos
Frutanos/metabolismo
[Mh] Termos MeSH secundário: Técnicas de Cocultura
Fermentação
Seres Humanos
Inulina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fructans); 9005-80-5 (Inulin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE


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[PMID]:27048834
[Au] Autor:Hippe B; Remely M; Aumueller E; Pointner A; Magnet U; Haslberger AG
[Ad] Endereço:1 Institute of Nutritional Sciences, Althanstr. 14, UZA 2, 1090 Vienna, Austria.
[Ti] Título:Faecalibacterium prausnitzii phylotypes in type two diabetic, obese, and lean control subjects.
[So] Source:Benef Microbes;7(4):511-7, 2016 Sep.
[Is] ISSN:1876-2891
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Faecalibacterium prausnitzii is one of the main butyrate producers in the healthy human gut. Information on its genetic diversity is lacking, although two genetic phylotypes have been differentiated. In the present study, F. prausnitzii phylotypes were examined in faeces of obese and type two diabetes with similar eating behaviour compared to a lean control group. The purpose of the study was to analyse if an excessive butyrate production induced by different F. prausnitzii phylotypes discriminates between obese developing type two diabetes or not. The faecal samples were analysed for the total abundance of F. prausnitzii 16S rRNA copies, fragment lengths polymorphism, high resolution melt curve analysis (HRM) and the butyryl-CoA:acetate CoA-transferase gene copies and melt curve variances. The diabetic group was found to differ significantly from the lean control group in the results of qPCR, butyryl-CoA:acetyate CoA-transferase gene melt curve, and HRM. F. prausnitzii phylotypes differed in obese with and without developed diabetes type two. Different phylotypes of F. prausnitzii may lead to differences in the inflammatory genesis in the host. F. prausnitzii phylotypes may have an influence on developing type two diabetes and might also act as starting points for prevention and therapy of obesity associated disease.
[Mh] Termos MeSH primário: Butiratos/metabolismo
Diabetes Mellitus Tipo 2/microbiologia
Faecalibacterium prausnitzii/metabolismo
Obesidade/microbiologia
[Mh] Termos MeSH secundário: Adulto
Diabetes Mellitus Tipo 2/etiologia
Faecalibacterium prausnitzii/classificação
Faecalibacterium prausnitzii/genética
Fezes/microbiologia
Feminino
Genes Bacterianos/genética
Seres Humanos
Masculino
Obesidade/complicações
Fenótipo
Polimorfismo de Fragmento de Restrição
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butyrates)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE
[do] DOI:10.3920/BM2015.0075



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