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[PMID]:28460559
[Au] Autor:Mani RJ; Thachil AJ; Ramachandran A
[Ad] Endereço:Oklahoma Animal Disease Diagnostic Laboratory, Oklahoma State University, Stillwater, OK (Mani, Ramachandran).
[Ti] Título:Discrimination of Streptococcus equi subsp. equi and Streptococcus equi subsp. zooepidemicus using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
[So] Source:J Vet Diagn Invest;29(5):622-627, 2017 Sep.
[Is] ISSN:1943-4936
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Accurate and timely identification of infectious etiologies is of great significance in veterinary microbiology, especially for critical diseases such as strangles, a highly contagious disease of horses caused by Streptococcus equi subsp. equi. We evaluated a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform for use in species- and subspecies-level identification of S. equi isolates from horses and compared it with an automated biochemical system. We used 25 clinical isolates each of S. equi subsp. equi and S. equi subsp. zooepidemicus. Using the MALDI-TOF MS platform, it was possible to correctly identify all 50 isolates to the species level. Unique mass peaks were identified in the bacterial peptide mass spectra generated by MALDI-TOF MS, which can be used for accurate subspecies-level identification of S. equi. Mass peaks (mass/charge, m/ z) 6,751.9 ± 1.4 (mean ± standard deviation) and 5,958.1 ± 1.3 were found to be unique to S. equi subsp. equi and S. equi subsp. zooepidemicus, respectively. The automated biochemical system correctly identified 47 of 50 of the isolates to the species level as S. equi, whereas at the subspecies level, 24 of 25 S. equi subsp. equi isolates and 22 of 25 S. equi subsp. zooepidemicus isolates were correctly identified. Our results indicate that MALDI-TOF MS can be used for accurate species- and subspecies-level identification of S. equi.
[Mh] Termos MeSH primário: Doenças dos Cavalos/diagnóstico
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/veterinária
Infecções Estreptocócicas/veterinária
Streptococcus equi/classificação
[Mh] Termos MeSH secundário: Animais
Doenças dos Cavalos/microbiologia
Cavalos
Especificidade da Espécie
Infecções Estreptocócicas/diagnóstico
Infecções Estreptocócicas/microbiologia
Streptococcus equi/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1177/1040638717702687


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[PMID]:28569630
[Au] Autor:Boyle AG; Smith MA; Boston RC; Stefanovski D
[Ti] Título:A case-control study developing a model for predicting risk factors for high SeM-specific antibody titers after natural outbreaks of Streptococcus equi subsp equi infection in horses.
[So] Source:J Am Vet Med Assoc;250(12):1432-1439, 2017 Jun 15.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To develop a risk prediction model for factors associated with an SeM-specific antibody titer ≥ 3,200 in horses after naturally occurring outbreaks of Streptococcus equi subsp equi infection and to validate this model. DESIGN Case-control study. ANIMALS 245 horses: 57 horses involved in strangles outbreaks (case horses) and 188 healthy horses (control horses). PROCEDURES Serum samples were obtained from the 57 cases over a 27.5-month period after the start of outbreaks; serum samples were obtained once from the 188 controls. A Bayesian mixed-effects logistic regression model was used to assess potential risk factors associated with an antibody titer ≥ 3,200 in the case horses. A cutoff probability for an SeM-specific titer ≥ 3,200 was determined, and the model was externally validated in the control horses. Only variables with a 95% credibility interval that did not overlap with a value of 1 were considered significant. RESULTS 9 of 57 (6%) case horses had at least 1 titer ≥ 3,200, and 7 of 188 (3.7%) of control horses had a titer ≥ 3,200. The following variables were found to be significantly associated with a titer ≥ 3,200 in cases: farm size > 20 horses (OR, 0.11), history of clinically evident disease (OR, 7.92), and male sex (OR, 0.11). The model had 100% sensitivity but only 24% specificity when applied to the 188 control horses (area under the receiver operating characteristic curve = 0.62.) CONCLUSIONS AND CLINICAL RELEVANCE Although the Bayesian mixed-effects logistic regression model developed in this study did not perform well, it may prove useful as an initial screening tool prior to vaccination. We suggest that SeM-specific antibody titer be measured prior to vaccination when our model predicts a titer ≥ 3,200.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/sangue
Surtos de Doenças/veterinária
Doenças dos Cavalos/epidemiologia
Infecções Estreptocócicas/veterinária
Streptococcus equi/imunologia
[Mh] Termos MeSH secundário: Animais
Especificidade de Anticorpos
Estudos de Casos e Controles
Surtos de Doenças/prevenção & controle
Feminino
Doenças dos Cavalos/microbiologia
Doenças dos Cavalos/prevenção & controle
Cavalos
Masculino
Modelos Teóricos
Pennsylvania/epidemiologia
Fatores de Risco
Sensibilidade e Especificidade
Infecções Estreptocócicas/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.2460/javma.250.12.1432


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[PMID]:28335829
[Au] Autor:Boyle AG; Stefanovski D; Rankin SC
[Ad] Endereço:Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Rd, Kennett Square, PA, 19348, USA. boylea@vet.upenn.edu.
[Ti] Título:Comparison of nasopharyngeal and guttural pouch specimens to determine the optimal sampling site to detect Streptococcus equi subsp equi carriers by DNA amplification.
[So] Source:BMC Vet Res;13(1):75, 2017 Mar 23.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Streptococcus equi subsp equi (S. equi) is the cause of "equine strangles" which is a highly infectious upper respiratory disease. Detection of S. equi is influenced by site of specimen collection, method of sampling, and type of diagnostic test that is performed. We hypothesized i) that a loop-mediated isothermal amplification (LAMP) assay that targets the S. equi-specific eqbE gene would be more sensitive than a realtime PCR assay that targets the S. equi-specific seeI gene and ii) that LAMP of specimens obtained by guttural pouch lavage (GPL) would be more sensitive than LAMP of nasopharyngeal specimens to identify S. equi carriers. METHODS: A nasopharyngeal flocked swab, nasopharyngeal wash, and GPL specimen was collected from 44 convalescent horses and the eqbE LAMP assay was performed. The seeI realtime PCR assay and aerobic culture were also performed on the GPL specimen. Logistic regression was performed to compare sampling sites and test methods (P-values ≤0.05 were considered significant). RESULTS: One of 41 nasopharyngeal flocked swabs, 6/38 nasopharyngeal wash and 24/44 GPL specimens were positive by eqbE LAMP. 18/44 GPL specimens were positive by seeI PCR and S. equi was isolated from 4/44 of these specimens. Detection of S. equi DNA was 51 times more likely from the GPL samples than nasopharyngeal samples (OR 51.0, P < 0.0001). When eqbE LAMP GPL samples were positive, it was eight times more likely that the guttural pouch had any abnormality on endoscopy (OR 8.2, P ≤ 0.005), almost 20 times more likely that mild empyema was found (OR 19.7, P ≤ 0.002), and eight times more likely that the SeeI PCR was positive for S. equi DNA (OR 8.1, P ≤ 0.006). CONCLUSION: This study demonstrates that guttural pouch lavage specimens should be used to detect S. equi and that the eqbE LAMP assay was comparable to the seeI PCR.
[Mh] Termos MeSH primário: Portador Sadio/veterinária
Doenças dos Cavalos/microbiologia
Nasofaringe/microbiologia
Infecções Estreptocócicas/veterinária
Streptococcus equi/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Portador Sadio/diagnóstico
Doenças dos Cavalos/diagnóstico
Cavalos
Linfadenite/microbiologia
Linfadenite/veterinária
Técnicas de Amplificação de Ácido Nucleico/veterinária
Reação em Cadeia da Polimerase em Tempo Real/veterinária
Manejo de Espécimes/veterinária
Infecções Estreptocócicas/diagnóstico
Infecções Estreptocócicas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-0989-4


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[PMID]:28272747
[Au] Autor:Patil S; Chaudhari B
[Ad] Endereço:Department of Microbiology and Biotechnology, R.C. Patel Arts, Commerce and Science College, Shirpur, India.
[Ti] Título:A simple, rapid and sensitive plate assay for detection of microbial hyaluronidase activity.
[So] Source:J Basic Microbiol;57(4):358-361, 2017 Apr.
[Is] ISSN:1521-4028
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Hyaluronidase (hyase) is a glycosidase enzyme that predominantly degrades hyaluronic acid (HA) having important applications in many biotechnological processes and therapeutics. Several assay methods have been proposed to screen hyase producing microorganisms; however, they rely on unique reagents and sophisticated instruments, which are expensive and could be unavailable in general laboratories. In the present studies, a rapid, simple, sensitive, highly reproducible, and cost-effective qualitative plate assay has been developed for the screening of hyase producing microorganisms. The routinely used plate assay method of Richman and Baer requires a special chemical cetylpyridinium chloride and long incubation period of 20 h; but still, the zones of clearance are not very clear and distinct. While, the present method requires an incubation period of only 1 h and the distinct zones of clearance appear with Gram's iodine within 1 min of time. This method does not require any special medium, unlike previously reported methods. Moreover, use of commonly available Gram's iodine makes this method suitable for many researchers. The results of the assay method were validated by TLC, zymographic analysis and determining the growth of isolates in minimal medium containing HA as a sole carbon source.
[Mh] Termos MeSH primário: Ensaios Enzimáticos/métodos
Hialuronoglucosaminidase/isolamento & purificação
Streptococcus equi/enzimologia
[Mh] Termos MeSH secundário: Meios de Cultura/química
Ensaios Enzimáticos/economia
Seres Humanos
Ácido Hialurônico/isolamento & purificação
Ácido Hialurônico/metabolismo
Hialuronoglucosaminidase/metabolismo
Iodo
Sensibilidade e Especificidade
Sefarose
Streptococcus equi/química
Streptococcus equi/crescimento & desenvolvimento
Streptococcus mitis/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media); 9004-61-9 (Hyaluronic Acid); 9012-36-6 (Sepharose); 9679TC07X4 (Iodine); EC 3.2.1.35 (Hyaluronoglucosaminidase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1002/jobm.201600579


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[PMID]:28271546
[Au] Autor:Arroyo MG; Slovis NM; Moore GE; Taylor SD
[Ad] Endereço:Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN.
[Ti] Título:Factors Associated with Survival in 97 Horses with Septic Pleuropneumonia.
[So] Source:J Vet Intern Med;31(3):894-900, 2017 May.
[Is] ISSN:1939-1676
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Septic pleuropneumonia is a common cause of morbidity and mortality in horses, but there is limited data available regarding factors associated with survival. HYPOTHESIS/OBJECTIVES: To identify factors predictive of survival in horses with septic pleuropneumonia. ANIMALS: A total of 97 horses with septic pleuropneumonia at 2 referral institutions. METHODS: A retrospective study was performed. A diagnosis of septic pleuropneumonia was based on the presence of sepsis, pleural effusion, and positive bacterial culture from tracheal aspiration (TA) or pleural fluid (PF). RESULTS: Thirty-one percent of horses had a recent history of travel. Clinical signs included lethargy (78%), tachycardia (75%), tachypnea (60%), fever (43%), prolonged capillary refill time (22%), and ventral edema (14%). The most common clinicopathologic abnormality was hyperfibrinogenemia (79%). Increased serum creatinine concentration at presentation was negatively associated with survival (OR, 5.13; CI, 1.88-14.01; P = .001) and return to work (OR, 6.46; CI, 1.10-37.92; P = .034). Eighty-four TA and 67 PF samples were submitted for culture, 98 and 84% of which were positive, respectively. The most common isolate was Streptococcus equi subsp zooepidemicus. Tracheal aspirates were more sensitive than PF for bacterial growth, but some organisms isolated from PF were not isolated from TA. Thoracotomy was positively associated with survival (OR, 0.13; CI, 0.01-0.83; P = .028). CONCLUSIONS AND CLINICAL IMPORTANCE: Increased serum creatinine concentration is a negative prognostic indicator and is likely a reflection of dehydration. Submission of TA and PF is recommended. Thoracotomy should be considered as a treatment for pleuropneumonia.
[Mh] Termos MeSH primário: Doenças dos Cavalos/mortalidade
Pleuropneumonia/veterinária
[Mh] Termos MeSH secundário: Animais
Feminino
Cavalos
Masculino
Derrame Pleural/mortalidade
Derrame Pleural/veterinária
Pleuropneumonia/microbiologia
Pleuropneumonia/mortalidade
Estudos Retrospectivos
Fatores de Risco
Sepse/mortalidade
Sepse/veterinária
Infecções Estreptocócicas/veterinária
Streptococcus equi
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1111/jvim.14679


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[PMID]:28201995
[Au] Autor:Kittang BR; Pettersen VK; Oppegaard O; Skutlaberg DH; Dale H; Wiker HG; Skrede S
[Ad] Endereço:Department of Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway. brki@haraldsplass.no.
[Ti] Título:Zoonotic necrotizing myositis caused by Streptococcus equi subsp. zooepidemicus in a farmer.
[So] Source:BMC Infect Dis;17(1):147, 2017 Feb 15.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Streptococcus equi subsp. zooepidemicus is a beta-hemolytic group C streptococcus mainly causing infections in domesticated animals. Here we describe the first case of zoonotic necrotizing myositis caused by this bacterium. CASE PRESENTATION: The patient was a 73-year-old, previously healthy farmer with two asymptomatic Shetland ponies in his stable. After close contact with the ponies while feeding them, he rapidly developed erythema of his left thigh and sepsis with multiple organ failure. The clinical course was severe and complicated, requiring repetitive surgical excision of necrotic muscle, treatment with vasopressors, mechanical ventilation and continuous venovenous hemofiltration, along with adjunctive hyperbaric oxygen therapy. The patient was discharged from hospital at day 30, without obvious sequelae. The streptococcal isolate was identified as Streptococcus equi by MALDI-ToF MS, and was later assigned subspecies identification as S. equi subsp. zooepidemicus. Multilocus sequence typing identified the strain as a novel sequence type (ST 364), closely related to types previously identified in horses and cattle. A focused proteomic analysis revealed that the ST 364 expressed putative virulence factors similar to that of Streptococcus pyogenes, including homologues of the M protein, streptodornases, interleukin 8-protease and proteins involved in the biosynthesis of streptolysin S. CONCLUSION: This case illustrates the zoonotic potential of S. equi subsp. zooepidemicus and the importance of early clinical recognition, rapid and radical surgical therapy, appropriate antibiotics and adequate supportive measures when necrotizing soft tissue infection is suspected. The expression of Streptococcus pyogenes-like putative virulence determinants in ST 364 might partially explain the fulminant clinical picture.
[Mh] Termos MeSH primário: Dermatomiosite/microbiologia
Fasciite Necrosante/microbiologia
Doenças dos Cavalos/microbiologia
Insuficiência de Múltiplos Órgãos/microbiologia
Infecções Estreptocócicas/microbiologia
Streptococcus equi/patogenicidade
[Mh] Termos MeSH secundário: Idoso
Criação de Animais Domésticos
Animais
Dermatomiosite/imunologia
Dermatomiosite/terapia
Fazendeiros
Fasciite Necrosante/terapia
Hemofiltração
Doenças dos Cavalos/imunologia
Cavalos
Seres Humanos
Oxigenação Hiperbárica
Masculino
Tipagem de Sequências Multilocus
Insuficiência de Múltiplos Órgãos/terapia
Infecções Estreptocócicas/terapia
Infecções Estreptocócicas/veterinária
Streptococcus equi/imunologia
Resultado do Tratamento
Vasoconstritores/uso terapêutico
Zoonoses
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasoconstrictor Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2262-7


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[PMID]:28177154
[Au] Autor:Waller AS
[Ad] Endereço:Animal Health Trust, Newmarket, UK.
[Ti] Título:Science-in-brief: Streptococcus zooepidemicus: a versatile opportunistic pathogen that hedges its bets in horses.
[So] Source:Equine Vet J;49(2):146-148, 2017 Mar.
[Is] ISSN:2042-3306
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças dos Cavalos/microbiologia
Infecções Estreptocócicas/veterinária
Streptococcus equi
[Mh] Termos MeSH secundário: Animais
Proteínas da Membrana Bacteriana Externa
Regulação Bacteriana da Expressão Gênica
Doenças dos Cavalos/patologia
Cavalos
Infecções Estreptocócicas/microbiologia
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Bacterial Outer Membrane Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1111/evj.12658


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[PMID]:28177153
[Au] Autor:Paillot R; Lopez-Alvarez MR; Newton JR; Waller AS
[Ad] Endereço:Animal Health Trust, Kentford, Newmarket, Suffolk, UK.
[Ti] Título:Strangles: A modern clinical view from the 17th century.
[So] Source:Equine Vet J;49(2):141-145, 2017 Mar.
[Is] ISSN:2042-3306
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças dos Cavalos/patologia
Infecções Estreptocócicas/veterinária
[Mh] Termos MeSH secundário: Animais
História do Século XVII
Doenças dos Cavalos/história
Doenças dos Cavalos/microbiologia
Doenças dos Cavalos/terapia
Cavalos
Infecções Estreptocócicas/história
Infecções Estreptocócicas/patologia
Infecções Estreptocócicas/terapia
Streptococcus equi
[Pt] Tipo de publicação:EDITORIAL; HISTORICAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1111/evj.12659


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[PMID]:28131378
[Au] Autor:Moriconi M; Acke E; Petrelli D; Preziuso S
[Ad] Endereço:School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95 62024 Matelica MC, Italy.
[Ti] Título:Multiplex PCR-based identification of Streptococcus canis, Streptococcus zooepidemicus and Streptococcus dysgalactiae subspecies from dogs.
[So] Source:Comp Immunol Microbiol Infect Dis;50:48-53, 2017 Feb.
[Is] ISSN:1878-1667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Streptococcus canis (S. canis), Streptococcus equi subspecies zooepidemicus (S. zooepidemicus) and Streptococcus dysgalactiae subspecies (S. dysgalactiae subspecies) are ß-haemolytic Gram positive bacteria infecting animals and humans. S. canis and S. zooepidemicus are considered as two of the major zoonotic species of Streptococcus, while more research is needed on S. dysgalactiae subspecies bacteria. In this work, a multiplex-PCR protocol was tested on strains and clinical samples to detect S. canis, S. dysgalactiae subspecies and S. equi subspecies bacteria in dogs. All strains were correctly identified as S. canis, S. equi subspecies or S. dysgalactiae subspecies by the multiplex-PCR. The main Streptococcus species isolated from symptomatic dogs were confirmed S. canis. The multiplex-PCR protocol described is a rapid, accurate and efficient method for identifying S. canis, S. equi subspecies and S. dysgalactiae subspecies in dogs and could be used for diagnostic purposes and for epidemiological studies.
[Mh] Termos MeSH primário: Doenças do Cão/microbiologia
Cães/microbiologia
Reação em Cadeia da Polimerase Multiplex/veterinária
Infecções Estreptocócicas/veterinária
Streptococcus equi/isolamento & purificação
Streptococcus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
DNA Bacteriano/genética
Seres Humanos
Reação em Cadeia da Polimerase Multiplex/economia
Reação em Cadeia da Polimerase Multiplex/métodos
RNA Ribossômico 16S/genética
Sensibilidade e Especificidade
Infecções Estreptocócicas/diagnóstico
Infecções Estreptocócicas/microbiologia
Streptococcus/classificação
Streptococcus/genética
Streptococcus equi/genética
Zoonoses/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


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[PMID]:28062002
[Au] Autor:Fu Q; Wei Z; Xiao P; Chen Y; Liu X
[Ad] Endereço:School of Life Science, Foshan University, Guangdong 528231, PR China; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
[Ti] Título:CD44 enhances macrophage phagocytosis and plays a protective role in Streptococcus equi subsp. zooepidemicus infection.
[So] Source:Vet Microbiol;198:121-126, 2017 Jan.
[Is] ISSN:1873-2542
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is an important pathogen associated with a wide range of diseases in many mammalian species. CD44 is a transmembrane adhesion molecule involved in innate and adaptive immune responses. The aim of this study was to determine the protective role of CD44 during S. zooepidemicus infection. CD44-deficient mice exhibited reduced macrophage accumulation in the bronchoalveolar space and enhanced bacterial outgrowth and dissemination, which resulted in reduced mouse survival. An in vitro analysis revealed that CD44 can directly bind to S. zooepidemicus. Additionally, S. zooepidemicus interacted with macrophage-associated CD44, as reflected by the reduced uptake of S. zooepidemicus by CD44-deficient macrophages. These data suggest that CD44 contributes to effective antibacterial defense during S. zooepidemicus infection, thereby limiting the accompanying injury and death.
[Mh] Termos MeSH primário: Doenças dos Cavalos/genética
Doenças dos Cavalos/imunologia
Receptores de Hialuronatos/metabolismo
Imunidade/genética
Macrófagos/imunologia
Fagocitose
Infecções Estreptocócicas/veterinária
[Mh] Termos MeSH secundário: Animais
Cavalos
Receptores de Hialuronatos/genética
Macrófagos/microbiologia
Camundongos
Fagocitose/genética
Fagocitose/imunologia
Infecções Estreptocócicas/genética
Infecções Estreptocócicas/imunologia
Streptococcus equi/fisiologia
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hyaluronan Receptors)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE



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