Base de dados : MEDLINE
Pesquisa : B03.353.750.737.872.243.500 [Categoria DeCS]
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[PMID]:29373594
[Au] Autor:Grimm I; Dumke J; Dreier J; Knabbe C; Vollmer T
[Ad] Endereço:Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinikum der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
[Ti] Título:Biofilm formation and transcriptome analysis of Streptococcus gallolyticus subsp. gallolyticus in response to lysozyme.
[So] Source:PLoS One;13(1):e0191705, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Streptococcus gallolyticus subsp. gallolyticus is a commensal bacterium of the human gastrointestinal tract, and a pathogen causing infective endocarditis and other biofilm-associated infections via exposed collagen. This study focuses on the characterization of the biofilm formation and collagen adhesion of S. gallolyticus subsp. gallolyticus under different conditions. In this study, it has been observed that the isolate UCN 34 is resistant to 20 mg/ml lysozyme in BHI medium, whereas the strain BAA-2069 builds more biofilm in the presence of lysozyme compared to in a control of BHI without lysozyme. A transcriptome analysis with whole genome microarrays of these two isolates in BHI medium with lysozyme compared to control without lysozyme revealed changes in gene expression levels. In the isolate BAA-2069, 67 genes showed increased expression in the presence of lysozyme, while in the isolate UCN 34, 165 genes showed increased expression and 30 genes showed decreased expression through lysozyme treatment. Products of genes which were higher expressed are in involved in transcription and translation, in cell-wall modification, in hydrogen peroxide resistance and in bacterial immunity. Furthermore, the adhesion ability of different strains of S. gallolyticus subsp. gallolyticus to collagen type I and IV was analyzed. Thereby, we compared the adhesion of 46 human isolates with 23 isolates from animals. It was shown that the adhesion ability depends significantly on whether the isolate was isolated from human or animal. For example, high adhesion ability was observed for strain UCN 34 isolated from an infective endocarditis patient, whereas strain DSM 16831 isolated from koala feces adhered only marginally to collagen. Full genome microarray analysis of these two strains revealed strain-dependent gene expression due to adhesion. The expression of 25 genes of a transposon and 15 genes of a phage region in strain DSM 16831 were increased, which corresponds to horizontal gene transfer. Adherence to collagen in strain UCN 34 led to higher expression of 27 genes and lower expression of 31 genes. This was suggestive of a change in nutrient uptake.
[Mh] Termos MeSH primário: Biofilmes
Muramidase/metabolismo
Streptococcus gallolyticus subspecies gallolyticus/metabolismo
Transcriptoma
[Mh] Termos MeSH secundário: Streptococcus gallolyticus subspecies gallolyticus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.2.1.17 (Muramidase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191705


  2 / 3 MEDLINE  
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[PMID]:28477334
[Au] Autor:Butt J; Werner S; Willhauck-Fleckenstein M; Michel A; Waterboer T; Zörnig I; Boleij A; Dramsi S; Brenner H; Pawlita M
[Ad] Endereço:Division of Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[Ti] Título:Serology of Streptococcus gallolyticus subspecies gallolyticus and its association with colorectal cancer and precursors.
[So] Source:Int J Cancer;141(5):897-904, 2017 Sep 01.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Streptococcus gallolyticus subspecies gallolyticus (SGG) is potentially associated with colorectal cancer (CRC) and its precursors. A previous case-control study measured antibody responses to SGG pilus proteins Gallo2178 and Gallo2179 and identified significant associations with a small fraction of CRC cases. We aimed at replicating and expanding these findings in an independent study including additional SGG antigens and explored the association with precancerous lesions. We applied multiplex serology to measure antibodies to eleven SGG proteins in serum samples of a screening colonoscopy trial (BliTz study) including participants diagnosed with either non-advanced adenoma (NAA, n = 30), advanced adenoma (AA, n = 100), CRC (n = 50) or controls (n = 228). In addition, we analyzed CRC samples (n = 318) from patients recruited in a clinical setting (DACHSplus study). The association of antibody responses to SGG pilus proteins Gallo2178 and Gallo2179 with CRC was replicated with 4% positive DACHSplus cases compared to 0% positive BliTz controls. Positivity to two or more proteins of a newly defined panel of six SGG markers was significantly associated with CRC in the DACHSplus study (OR: 1.81, 95% CI: 1.07-3.06). Odds for CRC, AA and NAA in the BliTz study were also increased with antibody responses to SGG, and the association was significant for NAA (OR: 2.98, 95% CI: 1.18-7.57). Antibody responses to SGG are associated with CRC and its precursors. The newly identified SGG six-marker panel and associations found with precancerous lesions should be further explored.
[Mh] Termos MeSH primário: Adenoma/microbiologia
Neoplasias Colorretais/microbiologia
Lesões Pré-Cancerosas/microbiologia
Infecções Estreptocócicas/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Anticorpos Antibacterianos/sangue
Antígenos de Bactérias/imunologia
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
Streptococcus gallolyticus subspecies gallolyticus/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Antigens, Bacterial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30765


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[PMID]:26992635
[Au] Autor:García-País MJ; Rabuñal R; Armesto V; López-Reboiro M; García-Garrote F; Coira A; Pita J; Rodríguez-Macías AI; López-Álvarez MJ; Alonso MP; Corredoira J
[Ad] Endereço:Infectious Disease Unit, Hospital Universitario Lucus Augusti, Lugo, Spain.
[Ti] Título:Streptococcus bovis septic arthritis and osteomyelitis: A report of 21 cases and a literature review.
[So] Source:Semin Arthritis Rheum;45(6):738-46, 2016 Jun.
[Is] ISSN:1532-866X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Streptococcus bovis group (SBG) is a well-known cause of endocarditis, but its role in osteoarticular infections (OAIs) has not been well described. METHODS: We analyzed all patients with OAIs by SBG diagnosed in our hospital (1988-2014). We selected those cases with septic arthritis and osteomyelitis, as defined according to clinical, microbiological, and imaging studies. Identification of the strains was performed by using the API 20 Strep and the GP card of the Vitek 2 system, and confirmed the identification by molecular methods. In addition, we reviewed the literature to select all cases of OAI by SBG during the period 1980-2015. RESULTS: From the 83 cases of OAI included in the analysis (21 from our center and 62 from the literature review), 59 were osteomyelitis (57 of them spondylodiscitis) and 24 were arthritis (2 with associated spondylodiscitis). The mean age was 66.9 years, and 79.2% of the patients were men. Endocarditis (IE) was associated with 59% of the cases and this association was greater for osteomyelitis than for arthritis (78.9% vs. 13.6%; P = 0.001). OAI was a presenting symptom in 63% of the cases of IE. Colonoscopy was performed in 64 cases, which detected colorectal neoplasm (CRN) in 46 patients (71.8%), almost all asymptomatic. Some 69.5% of these neoplasm were carcinomas or advanced adenomas. The blood cultures were positive in 78.3% cases. In 45 cases, the S. bovis species was identified; in 82.2% of the cases the cause was Streptococcus gallolyticus subsp. gallolyticus. The mortality was 7.2%, which in no case was attributable to the OAI. CONCLUSIONS: OAIs are frequently the initial manifestation of IE caused by SBG. S. gallolyticus causes most of these infections. Echocardiogram and colonoscopy are therefore mandatory, given the species' close association with IE and CRN.
[Mh] Termos MeSH primário: Adenoma/complicações
Artrite Infecciosa/complicações
Carcinoma/complicações
Neoplasias Colorretais/complicações
Discite/complicações
Endocardite Bacteriana/complicações
Osteomielite/complicações
Infecções Estreptocócicas/complicações
[Mh] Termos MeSH secundário: Adenoma/diagnóstico
Adulto
Idoso
Idoso de 80 Anos ou mais
Antibacterianos/uso terapêutico
Artrite Infecciosa/microbiologia
Artrite Infecciosa/terapia
Carcinoma/diagnóstico
Neoplasias Colorretais/diagnóstico
Discite/microbiologia
Discite/terapia
Drenagem
Feminino
Seres Humanos
Masculino
Meia-Idade
Osteomielite/microbiologia
Osteomielite/terapia
Infecções Estreptocócicas/microbiologia
Infecções Estreptocócicas/terapia
Streptococcus bovis
Streptococcus gallolyticus subspecies gallolyticus
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160320
[St] Status:MEDLINE



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