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[PMID]:28387901
[Au] Autor:Merra G; Marsiliani D; Di Giambenedetto S; Franceschi F
[Ad] Endereço:Department of Emergency Medicine, Catholic University of the Sacred Heart, School of Medicine, Rome, Italy. giuseppe.merra@policlinicogemelli.it.
[Ti] Título:Endocarditis sustained by Streptococcus viridans with normal levels of procalcitonin: an unexpected finding.
[So] Source:Eur Rev Med Pharmacol Sci;21(6):1281-1284, 2017 Mar.
[Is] ISSN:2284-0729
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Procalcytonin is a useful marker of bacterial infections. Several studies have reported elevated serum levels of PCT in patients with infective endocarditis (IE) and/or other infections sustained by cocci. We report a rare case of IE attributed to Streptococcus viridans in whom levels of PCT were normal. CASE REPORT: A 67 years-old male was admitted to the Emergency Department for a 25-day history of recurring night fever. Upon admission, patient underwent blood test, including PCT, showing normal levels, except for a slight increased creatinine concentration (1.6 mg/dl). CBC showed WBC levels of 10.24 x 10^9/l with neutrophil concentration of 8.64 x 10^9/l. Three blood culture were performed, and all of them were positive for Streptococcus viridans (S. oralis). Dosage of PCT was then repeated two times within the next 2 days after the admission, with negative results. An echocardiogram was performed, showing a lesion of the left anterior aortic leaflet. This finding was confirmed by a transoesophageal echocardiogram. The patient was then treated with G penicillin (6 million of Units quid) for 3 weeks; during the course of antibiotic therapy fever disappeared and blood cultures become negative. CONCLUSIONS: In the literature, there are just few data about the association between PCT levels and endocarditis and sepsis but there are not etiological differentiations particularly for those sustained by Streptococcus viridans. Only one study suggests that a Streptococcus viridans' infection could reduce PCT accuracy in diagnosis oh endocarditis. So, our observation although come from a single case, could merits, further investigation.
[Mh] Termos MeSH primário: Calcitonina/sangue
Endocardite Bacteriana/sangue
Infecções Estreptocócicas/sangue
Estreptococos Viridans
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Masculino
Infecções Estreptocócicas/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
9007-12-9 (Calcitonin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE


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[PMID]:28283005
[Au] Autor:Süzük Yildiz S; Kaskatepe B; Altinok S; Çetin M; Karagöz A; Savas S
[Ad] Endereço:Public Health Agency of Turkey, Department of Microbiology Reference Laboratories, Ankara, Turkey. serapsuzuk@gmail.com.
[Ti] Título:[Comparison of MALDI-TOF and 16S rRNA methods in identification of viridans group streptococci].
[Ti] Título:Viridans grup streptokok tanimlamasinda MALDI-TOF ve 16S rRNA yöntemlerinin karsilastirilmasi..
[So] Source:Mikrobiyol Bul;51(1):1-9, 2017 Jan.
[Is] ISSN:0374-9096
[Cp] País de publicação:Turkey
[La] Idioma:tur
[Ab] Resumo:Accurate identification of viridans group streptococci (VGS) frequently encountered as a causative agent of infective endocarditis is always a challenge for the clinical microbiology laboratory. Clinical microbiology laboratories generally use semi automatic/full automatic systems, molecular methods and also conventional methods for the identification of these bacteria. There are recent published studies that have used MALDI-TOF (Matrix Assisted Laser Ionization Mass Spectrometry-Time of Flight) systems in the identification of VGS. The aim of the study was to compare the performance of the conventional methods, semi automatic and MALDI-TOF MS system used in identification of VGS in oral microbiota of persons under the risk of infective endocarditis, with the gold standard method 16S rRNA sequence analysis and to create a diagnosis algorithm for the identification of VGS in clinical microbiology laboratories according to the obtained data.The study was conducted with 51 VGS strains isolated from oral microbiota of the patients with rheumatologic cardiac, valve and/or prosthetic valve diseases, under the risk of development of infective endocarditis, who have admitted to Ankara Numune Training and Research Hospital, Department of Cardiology, between February-June 2015. Standard microbiology procedures, optochin susceptibility and bile solubility tests were done for the isolation of bacteria. Bacteria were also identified with APISTREP (bioMérieux, France) and MALDI-TOF MS Bruker Microflex (Bruker Biotyper; Bruker Daltonics, Bremen, Germany) methods. BSF-8 (5´-AGAGTTTGATCCTGGCTCAG-3´) and BSR-534(5´-ATTACCGCGGCTGCTGGC-3´) primers were used in the 16S rRNA sequence analysis of bacteria. ABI PRISM 3100 Avan t Genetic Analyzer (Applied Biossytems, Foster City, CA, USA) were used for the sequence analysis. Electropherograms were analyzed in SeqScape Software (Applied Biosystems, Foster City, CA, USA) and compared with the reference sequences in GenBank with BLASTN (NCBI). According to the result of optochin and bile solubility tests, with API STREP system, 16 (31,37%) of the isolates were identified as Mitis group, 15 (29.41%) as Anginosus group, 9 (17.5%) as Salivarius group, 7 (13,73%) as Sanguinis group and 4 (7.84%) as Bovis group among optochin and bile resistant alpha hemolytic streptococci. Moreover, of the same isolates 20 (39.22%) were identified as Mitis group, 14 (27.45%) as Anginosus group, 13 (25.49%) as Salivarius group and 4 (7.84%) as Sanguinis group with MALDI-TOF system. In the identification with 16S rRNA, 25 (49.02%) of the isolates were identified as Mitis group, 13 (25.49%) as Anginosus group, 12 (23.53%) as Salivarius group and 1 (1.96%) as Sanguinis group. According to the results, it was determined that 33 (64.70%) of the isolates identified in MALDI-TOF MS system and 31 (60.78%) of the isolates identified in API STREP system were compatible with 16S rRNA sequence analysis method. For Mitis group, API STREP test sensitivity was 48.00% and specificity was 84.62% and MALDI-TOF system sensitivity was 80.00% and specificity was 100%. As VGS identification is a complicated process, we believe a single method will be insufficient for the identification of these isolates in clinical microbiology laboratories. We suggest that MALDI-TOF system can be used for VGS diagnosis, however, optochin test and/or molecular methods should also be included in the diagnosis algorithm when necessary.
[Mh] Termos MeSH primário: RNA Ribossômico 16S/química
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Estreptococos Viridans/isolamento & purificação
[Mh] Termos MeSH secundário: Algoritmos
Seres Humanos
Sensibilidade e Especificidade
Estreptococos Viridans/classificação
Estreptococos Viridans/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


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[PMID]:28061897
[Au] Autor:Liu Y; Wang X; Wang Z; Zhu Y; Zhang L; Li X; Xu R; Ge W
[Ad] Endereço:Department of Geriatrics, Xijing Hospital, Fourth Military Medical University, Changle West Road #127, Xi'an, Shaanxi Province, 710032, People's Republic of China.
[Ti] Título:Bacteria endocarditis consolidation with vertebra bone tuberculosis: a case report.
[So] Source:BMC Infect Dis;17(1):38, 2017 Jan 06.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The clinical features of bacteria endocarditis became atypical when consolidated with other conditions such as tuberculosis (TB). Especially, the symptoms of bacteria endocarditis (BE) which were hidden behind the TB fever often lead to misdiagnosis and missed diagnosis. CASE PRESENTATION: A 56-year-old male with thoracic vertebra bone TB history presented with low-grade fever, shortness of breath and cardiac souffle. After conventional antibiotic therapy and strengthen anti-tuberculosis treatment condition did not be improved. Further inspection, there were bacteria endocarditis with the vegetation across the mitral valve. But the other valves were not involved. He was treated with intravenous penicillin for 4 weeks in all including during surgery, and following with oral antibiotic for another 2 weeks. The patient improved clinically eventually. CONCLUSION: It is the first reported case of isolated thoracic vertebra tuberculosis with valve endocarditis caused by streptococcus viridans and was successfully managed by combination therapy of internal medicine and surgery. It was suggested in tuberculosis patients, the possibility of bacterial endocarditis should be considered when came into fever and unexplained cardiac soufflé (in tuberculosis patients).
[Mh] Termos MeSH primário: Endocardite Bacteriana/tratamento farmacológico
Infecções Estreptocócicas/tratamento farmacológico
Tuberculose Osteoarticular/tratamento farmacológico
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Antituberculosos/uso terapêutico
Endocardite Bacteriana/microbiologia
Seres Humanos
Masculino
Meia-Idade
Valva Mitral/microbiologia
Penicilinas/administração & dosagem
Penicilinas/uso terapêutico
Estreptococos Viridans/patogenicidade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antitubercular Agents); 0 (Penicillins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-016-2168-9


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[PMID]:27862152
[Au] Autor:Matsumoto A; Al-Rohil RN; Bravin M; Anderson L; Wroblewski D; Carlson JA
[Ad] Endereço:Department of Pathology, Albany Medical College, Albany, NY, USA.
[Ti] Título:Cutaneous polyarteritis nodosa localized to a region of lymphedema secondary to Streptococcus viridans cellulitis and multiple surgeries.
[So] Source:J Cutan Pathol;44(2):210-216, 2017 Feb.
[Is] ISSN:1600-0560
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cutaneous polyarteritis nodosa (CPAN) is a chronic, indolent, single organ arteritis that generally presents with lower extremity nodules and/or livedo racemosa, accompanied by malaise and arthralgias. CPAN is often triggered by infection, commonly Group A streptococcal species, and is considered an autoimmune reaction. Scarring from surgery and obliterative lymphangiitis from bacterial cellulitis are the causes of lymphedema. Lymphedematous skin is predisposed to autoimmune disorders. Herein we report a 53-year-old woman who developed CPAN restricted to a localized area of the right upper arm-shoulder that had undergone multiple surgeries, complicated by episodes of Streptococcus viridans cellulitis. Clinically, a 15 cm diameter plaque exhibited violaceous, reticulate margins, subtle papules and nodules and central livedo racemosa. Biopsy showed numerous foci of arteritis in active, subacute and reparative stages. In addition, a broad zone of fibrosis replaced the deep dermis-subcutis zone and harbored numerous dilated lymphatic vessels scar lymphedema. Treatment consisted of high potency topical corticosteroids under occlusion; remission after 3 months therapy and follow-up. CPAN primarily affects the lower legs, a region of frequently affected by phlebolymphedema. This report of CPAN localized to an area of scar lymphedema underscores the importance of lymphatic function in the pathogenesis of CPAN.
[Mh] Termos MeSH primário: Doenças Autoimunes/patologia
Poliarterite Nodosa/patologia
[Mh] Termos MeSH secundário: Doenças Autoimunes/etiologia
Celulite (Flegmão)/microbiologia
Feminino
Seres Humanos
Linfedema/etiologia
Linfedema/patologia
Meia-Idade
Poliarterite Nodosa/etiologia
Ombro/cirurgia
Pele/patologia
Infecções Estreptocócicas/complicações
Estreptococos Viridans
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1111/cup.12861


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[PMID]:27699447
[Au] Autor:Boztug H; Mühlegger N; Pötschger U; Attarbaschi A; Peters C; Mann G; Dworzak M
[Ad] Endereço:St. Anna Kinderspital and Children's Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, Kinderspitalgasse 6, 1090, Vienna, Austria. heidrun.boztug@stanna.at.
[Ti] Título:Antibiotic prophylaxis with teicoplanin on alternate days reduces rate of viridans sepsis and febrile neutropenia in pediatric patients with acute myeloid leukemia.
[So] Source:Ann Hematol;96(1):99-106, 2017 Jan.
[Is] ISSN:1432-0584
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Intensive chemotherapy directed against acute myeloid leukemia of childhood is followed by profound neutropenia and high risk for bacterial and fungal infections, including viridans group streptococci as a common cause for gram-positive septicemia. Few retrospective studies have shown the efficacy of various antibiotic prophylactic regimens in children. We retrospectively studied 50 pediatric patients treated on the AML-BFM 2004 protocol between 2005 and 2015 at St. Anna Children's Hospital and assessed the effect of antibiotic prophylaxis on the frequency of febrile neutropenia and bacterial sepsis. Fifty pediatric patients underwent 199 evaluable chemotherapy cycles. Viridans sepsis occurred after none of 98 cycles with prophylactic administration of teicoplanin/vancomycin in comparison to 12 cases of viridans sepsis among 79 cycles without systemic antibacterial prophylaxis (0 vs. 15 %, p < 0.0001). In addition, there were significantly fewer episodes of febrile neutropenia in the teicoplanin/vancomycin group (44 % vs. no prophylaxis 82 %, p < 0.0001). Severity of infection seemed to be worse when no antibiotic prophylaxis had been administered with a higher rate of intensive care unit treatment (0/98, 0 %, vs. 4/79, 5 %, p = 0.038). So far, no increase of vancomycin-resistant enterococcus isolates in surveillance cultures was noticed. Antibiotic prophylaxis with teicoplanin (or vancomycin) appears safe and feasible and resulted in eradication of viridans sepsis and decreased incidence of febrile neutropenia in pediatric AML patients. The possibility to administer teicoplanin on alternate days on an outpatient basis or at home could contribute to patient's quality of life and decrease health care costs.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Antibioticoprofilaxia/métodos
Neutropenia Febril/tratamento farmacológico
Sepse/tratamento farmacológico
Teicoplanina/administração & dosagem
Estreptococos Viridans/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Esquema de Medicação
Neutropenia Febril/diagnóstico
Neutropenia Febril/epidemiologia
Feminino
Seres Humanos
Lactente
Masculino
Estudos Retrospectivos
Sepse/diagnóstico
Sepse/epidemiologia
Estreptococos Viridans/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 61036-62-2 (Teicoplanin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE
[do] DOI:10.1007/s00277-016-2833-5


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[PMID]:27372074
[Au] Autor:Minamimura H; Ishikawa T; Murakami T; Kotani S
[Ad] Endereço:Department of Cardiovascular Surgery, Bell Land General Hospital, 500-3 Higashiyama, Naka-ku, Sakai, Osaka, 599-8247, Japan. h_minamimura@sechokai.or.jp.
[Ti] Título:Aortic valve aneurysm associated with infective endocarditis: case report and review of literature.
[So] Source:Gen Thorac Cardiovasc Surg;65(7):408-414, 2017 Jul.
[Is] ISSN:1863-6713
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Although there are several mitral valve aneurysm reports, studies on aortic valve aneurysm are extremely rare. This paper describes an uncommon case of a large saccular aortic valve aneurysm associated with infective endocarditis. A 37-year-old man was hospitalized in our hospital with fever and dyspnea. Echocardiography found severe aortic regurgitation and aortic valve aneurysm of the non-coronary cusp going in and out of the left ventricular chamber. Blood cultures grew Streptococcus viridance. Therefore, the patient underwent aortic valve replacement. During the operation, we observed a 30 × 20 mm ruptured aneurysm that arose from the non-coronary cusp. The aortic valve containing the aneurysm was resected and replaced with a mechanical heart valve. Histopathological examination of the aortic valve aneurysm showed active inflammatory changes. Infective endocarditis was considered to be the cause of this aortic valve aneurysm.
[Mh] Termos MeSH primário: Insuficiência da Valva Aórtica/etiologia
Valva Aórtica
Endocardite Bacteriana/complicações
Aneurisma Cardíaco/complicações
Implante de Prótese de Valva Cardíaca/métodos
Infecções Estreptocócicas/complicações
[Mh] Termos MeSH secundário: Adulto
Insuficiência da Valva Aórtica/diagnóstico
Insuficiência da Valva Aórtica/cirurgia
Ecocardiografia Doppler em Cores
Endocardite Bacteriana/diagnóstico
Aneurisma Cardíaco/diagnóstico
Aneurisma Cardíaco/cirurgia
Seres Humanos
Masculino
Infecções Estreptocócicas/diagnóstico
Estreptococos Viridans/isolamento & purificação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160704
[St] Status:MEDLINE
[do] DOI:10.1007/s11748-016-0681-9


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[PMID]:27934818
[Au] Autor:Menon T
[Ad] Endereço:Department of Microbiology, Dr AL Mudaliar, Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India.
[Ti] Título:Understanding the viridians group streptococci: Are we there yet?
[So] Source:Indian J Med Microbiol;34(4):421-426, 2016 Oct-Dec.
[Is] ISSN:1998-3646
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:The viridans group streptococci are a heterogeneous group of organisms which exist as commensals in the oropharynx and the gut. They cause serious infections when they gain entry into sterile sites particularly in patients with predisposing conditions. Classification and species differentiation of these organisms has always been a challenge because of phenotypic differences between strains of the same species. Facklam's typing scheme based on six metabolic properties has been the most widely used and many commercial identification systems are based on it. Due to the ambiguity in species differentiation based on phenotypic tests, nucleic acid-based methods have been developed to improve the identification of these organisms. Results using genotypic methods such as 16S rRNA and sodA gene sequencing have been promising. Multilocus sequence analysis of seven house-keeping genes map, pfl, pyk, ppaC, rpoB, soda and tuf amplified by polymerase chain reaction was found to be an accurate alternative to other methods and could be useful in the characterisation of larger collections of isolates.
[Mh] Termos MeSH primário: Técnicas de Tipagem Bacteriana/métodos
Técnicas de Diagnóstico Molecular/métodos
Infecções Estreptocócicas/diagnóstico
Estreptococos Viridans/classificação
Estreptococos Viridans/isolamento & purificação
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Seres Humanos
Tipagem de Sequências Multilocus
RNA Bacteriano/genética
RNA Ribossômico 16S/genética
Infecções Estreptocócicas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (RNA, Bacterial); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE
[do] DOI:10.4103/0255-0857.195371


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[PMID]:27595678
[Au] Autor:Chirillo F; Faggiano P; Cecconi M; Moreo A; Squeri A; Gaddi O; Cecchi E; Italian Registry on Infective Endocarditis (RIEI) Investigators
[Ad] Endereço:Unità Operativa Complessa di Cardiologia, Ospedale Ca' Foncello, Treviso, Italy. Electronic address: fchirillo@tin.it.
[Ti] Título:Predisposing cardiac conditions, interventional procedures, and antibiotic prophylaxis among patients with infective endocarditis.
[So] Source:Am Heart J;179:42-50, 2016 Sep.
[Is] ISSN:1097-6744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Efficacy and safety of antibiotic prophylaxis (AP) for prevention of infective endocarditis (IE) in patients with predisposing cardiac condition (PCC) undergoing invasive procedures is still debated. We sought to assess the prevalence of PCC, the type of interventional procedures preceding the onset of symptoms, and the usefulness of AP in a large cohort of consecutive patients with definite IE. METHODS: We examined 677 (median age 65.34 years; male 492 [73%]) consecutive patients with IE enrolled from July 2007 through 2010 into the Italian Registry of Infective Endocarditis. RESULTS: Predisposing cardiac condition was present in 341 patients (50%).Thirty-two patients (4.7%) underwent dental procedures. Of 20 patients with PCC undergoing dental procedure, 13 had assumed AP. Viridans group streptococci were isolated from blood cultures in 8 of 20 patients with PCC and prior dental procedure. Nondental procedures preceded IE in 139 patients (21%). They were significantly older and had more comordibities compared with patients undergoing dental procedures. Predisposing cardiac condition was identified in 91 patients. Perioperative antimicrobial prophylaxis was administered to 67 patients. Staphylococcus aureus was the most frequent causative agent. Cardiac surgery was necessary in 85 patients (20 with prior dental and 65 with nondental procedure). Surgical mortality (12% vs 0%, P = .03) and hospital mortality (23% vs 3%, P = .001) were significantly larger among patients with nondental procedures. CONCLUSIONS: In a large unselected cohort of patients with IE, the incidence of preceding dental procedures was minimal. The number of cases potentially preventable by means of AP was negligible. Nondental procedures were more frequent than dental procedures and were correlated with poorer prognosis.
[Mh] Termos MeSH primário: Antibioticoprofilaxia/métodos
Endocardite Bacteriana/epidemiologia
Doenças das Valvas Cardíacas/epidemiologia
Próteses Valvulares Cardíacas/estatística & dados numéricos
Complicações Pós-Operatórias/epidemiologia
Infecções Estafilocócicas/epidemiologia
Infecções Estreptocócicas/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Procedimentos Cirúrgicos Cardíacos
Estudos de Coortes
Desfibriladores Implantáveis
Implantação Dentária
Raspagem Dentária
Endocardite/epidemiologia
Endocardite/prevenção & controle
Endocardite Bacteriana/prevenção & controle
Feminino
Seres Humanos
Incidência
Itália/epidemiologia
Masculino
Meia-Idade
Complicações Pós-Operatórias/prevenção & controle
Implante de Prótese
Fatores de Risco
Tratamento do Canal Radicular
Infecções Estafilocócicas/prevenção & controle
Staphylococcus aureus
Extração Dentária
Procedimentos Cirúrgicos Vasculares
Estreptococos Viridans
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170525
[Lr] Data última revisão:
170525
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


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[PMID]:27583858
[Au] Autor:Zhang X; Liu X; Yang M; Dong H; Xv L; Li L
[Ad] Endereço:State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
[Ti] Título:Occurrence of infective endocarditis following endoscopic variceal ligation therapy: A case report.
[So] Source:Medicine (Baltimore);95(35):e4482, 2016 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Endoscopic variceal ligation (EVL) is the endoscopic treatment of acute esophageal variceal hemorrhage, however, prophylaxis antibiotic during EVL is controversial. METHODS: We reported a 60-year-old man with diabetes, liver cirrhosis and hepatocellular carcinoma who received EVL for esophageal variceal haemorrhage. RESULTS: On the second day after EVL, the patient developed fever and chills. A week after EVL, the blood cultures were viridans streptococcus positive, and echocardiogram showed a vegetation on the cardiac valve. The patient was therefore diagnosed with infective endocarditis (IE). The patient was cured after 7 weeks of intravenous piperacillin sulbactam sodium. No complications were observed during the 3-month follow-up after discharge. CONCLUSION: To our knowledge, this is the first documented case to report IE caused by viridans streptococcus after EVL. Therefore, whether prophylaxis antibiotic should be administered to cirrhotic patients receiving EVL is worth further research.
[Mh] Termos MeSH primário: Endocardite Bacteriana/etiologia
Varizes Esofágicas e Gástricas/cirurgia
Hemorragia Gastrointestinal/cirurgia
Infecções Estreptocócicas
Estreptococos Viridans
[Mh] Termos MeSH secundário: Endocardite Bacteriana/microbiologia
Endoscopia Gastrointestinal/efeitos adversos
Seres Humanos
Ligadura/efeitos adversos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004482


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[PMID]:27495798
[Au] Autor:Kimura M; Araoka H; Yoshida A; Yamamoto H; Abe M; Okamoto Y; Yuasa M; Kaji D; Kageyama K; Nishida A; Ishiwata K; Takagi S; Yamamoto G; Asano-Mori Y; Uchida N; Hishinuma A; Izutsu K; Wake A; Taniguchi S; Yoneyama A
[Ad] Endereço:Department of Infectious Diseases, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan. muneyoshi-k@toranomon.gr.jp.
[Ti] Título:Breakthrough viridans streptococcal bacteremia in allogeneic hematopoietic stem cell transplant recipients receiving levofloxacin prophylaxis in a Japanese hospital.
[So] Source:BMC Infect Dis;16:372, 2016 Aug 05.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Breakthrough viridans streptococcal bacteremia (VSB) in patients with hematological malignancy receiving levofloxacin prophylaxis is a major blood stream infection (BSI) occurring during febrile neutropenia. However, clinical data focused on VSB in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are lacking. METHODS: The medical records of allo-HSCT recipients who received oral levofloxacin prophylaxis between January 2011 and August 2013 at Toranomon Hospital were reviewed to evaluate breakthrough VSB. Stored viridans streptococcal (VGS) species were identified by using sodA gene sequencing, and were assessed for drug susceptibility. RESULTS: Among the 184 allo-HSCT recipients on levofloxacin prophylaxis, 28 (15.2 %) experienced breakthrough VSB. All of the 28 recipients with VSB were treated with a cefepime-based or piperacillin/tazobactam-based regimen. The susceptibility rates of the VGS strains for levofloxacin, cefepime, piperacillin/tazobactam, meropenem, and vancomycin were 0 %, 95 %, 100 %, 100 %, and 100 %, respectively. Both the MIC50 (minimum inhibitory concentration) and the MIC90 of ceftazidim (0.5 µg/mL and 2 µg/mL, respectively) were higher than the MIC90 of all the other anti-pseudomonal beta-lactams (APBLs). Only 1 VGS strain had a penicillin MIC ≥ 2 µg/mL by the Etest (3.6 %). There were no cases with acute respiratory distress syndrome (ARDS) that was associated with VSB, although the rate of viridans group streptococcal shock syndrome was high (26 %). The crude 30-day mortality rate in the VSB group (10.7 %) did not differ significantly from that in the BSI without VSB group (9.3 %) or non-BSI group (7.0 %) (P = 0.77). Also, VSB was not a risk factor for all-cause mortality up to 60 days following allo-HSCT (P = 0.43). CONCLUSIONS: APBL with increased anti-VGS activity (APBL-VA) monotherapy would typically be optimal for treating the VGS strains in this setting. Indication of adding an empiric anti-gram-positive agent to APBL-VA for treating VSB should depend on local factors, such as the susceptibility results. In addition, breakthrough VSB is probably not a major cause of death in allo-HSCT settings, where beta-lactam non-susceptible VGS and the ARDS are rare.
[Mh] Termos MeSH primário: Bacteriemia/tratamento farmacológico
Neoplasias Hematológicas/terapia
Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Levofloxacino/uso terapêutico
Infecções Estreptocócicas/prevenção & controle
Estreptococos Viridans/isolamento & purificação
[Mh] Termos MeSH secundário: Adulto
Idoso
Antibioticoprofilaxia/métodos
Bacteriemia/epidemiologia
Bacteriemia/microbiologia
Feminino
Neoplasias Hematológicas/complicações
Neoplasias Hematológicas/epidemiologia
Hospitais
Seres Humanos
Japão/epidemiologia
Masculino
Meia-Idade
Estudos Retrospectivos
Infecções Estreptocócicas/epidemiologia
Infecções Estreptocócicas/microbiologia
Condicionamento Pré-Transplante/métodos
Transplante Homólogo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
6GNT3Y5LMF (Levofloxacin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160807
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-016-1692-y



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