Base de dados : MEDLINE
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[PMID]:29216329
[Au] Autor:Sekizuka T; Ogasawara Y; Ohkusa T; Kuroda M
[Ad] Endereço:Laboratory of Bacterial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan.
[Ti] Título:Characterization of Fusobacterium varium Fv113-g1 isolated from a patient with ulcerative colitis based on complete genome sequence and transcriptome analysis.
[So] Source:PLoS One;12(12):e0189319, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fusobacterium spp. present in the oral and gut flora is carcinogenic and is associated with the risk of pancreatic and colorectal cancers. Fusobacterium spp. is also implicated in a broad spectrum of human pathologies, including Crohn's disease and ulcerative colitis (UC). Here we report the complete genome sequence of Fusobacterium varium Fv113-g1 (genome size, 3.96 Mb) isolated from a patient with UC. Comparative genome analyses totally suggested that Fv113-g1 is basically assigned as F. varium, in particular, it could be reclassified as notable F. varium subsp. similar to F. ulcerans because of partial shared orthologs. Compared with the genome sequences of F. varium ATCC 27725 (genome size, 3.30 Mb) and other strains of Fusobacterium spp., Fv113-g1 possesses many accessary pan-genome sequences with noteworthy multiple virulence factors, including 44 autotransporters (type V secretion system, T5SS) and 13 Fusobacterium adhesion (FadA) paralogs involved in potential mucosal inflammation. Indeed, transcriptome analysis demonstrated that Fv113-g1-specific accessary genes, such as multiple T5SS and fadA paralogs, showed notably increased expression with D-MEM cultivation than with brain heart infusion broth. This implied that growth condition may enhance the expression of such potential virulence factors, leading to remarkable survival against other gut microorganisms and to the pathogenicity to human intestinal epithelium.
[Mh] Termos MeSH primário: Colite Ulcerativa/microbiologia
Fusobacterium/isolamento & purificação
Genoma Bacteriano
Transcriptoma
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Fusobacterium/genética
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189319


  2 / 1339 MEDLINE  
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[PMID]:27777193
[Au] Autor:Hu XY; Yao YF; Cui BM; Lv J; Shen X; Ren B; Li MY; Guo Q; Huang RJ; Li Y
[Ad] Endereço:State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China. E-mail: drhuxiaoyu@163.com.
[Ti] Título:[Analysis of causes and whole microbial structure in a case of rampant caries].
[So] Source:Nan Fang Yi Ke Da Xue Xue Bao;36(10):1328-1333, 2016 Oct 20.
[Is] ISSN:1673-4254
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To analyze the whole microbial structure in a case of rampant caries to provide evidence for its prevention and treatment. METHODS: Clinical samples including blood, supragingival plaque, plaque in the caries cavity, saliva, and mucosal swabs were collected with the patient's consent. The blood sample was sent for routine immune test, and the others samples were stained using Gram method and cultured for identifying colonies and 16S rRNA sequencing. DNA was extracted from the samples and tested for the main cariogenic bacterium (Streptococcus mutans) with qPCR, and the whole microbial structure was analyzed using DGGE. RESULTS: The patient had a high levels of IgE and segmented neutrophils in his blood. Streptococci with extremely long chains were found in the saliva samples under microscope. Culture of the samples revealed the highest bacterial concentration in the saliva. The relative content of hemolytic bacterium was detected in the samples, the highest in the caries cavity; C. albicans was the highest in the dental plaque. In addition, 33 bacterial colonies were identified by VITEK system and 16S rDNA sequence phylogenetic analysis, and among them streptococci and Leptotrichia wade were enriched in the dental plaque sample, Streptococcus mutans, Fusobacterium nucleatum, and Streptococcus tigurinus in the caries cavity, and Lactobacillus in the saliva. S. mutans was significantly abundant in the mucosal swabs, saliva and plaque samples of the caries cavity as shown by qPCR. Compared to samples collected from a healthy individual and another two patients with rampant caries, the samples from this case showed a decreased bacterial diversity and increased bacterial abundance shown by PCR-DGGE profiling, and multiple Leptotrichia sp. were detected by gel sequencing. CONCLUSION: The outgrowth of such pathogenic microorganisms as S. mutans and Leptotrichia sp., and dysbiosis of oral microbial community might contribute to the pathogenesis of rampant caries in this case.
[Mh] Termos MeSH primário: Cárie Dentária/microbiologia
Microbiota
[Mh] Termos MeSH secundário: Anormalidades Múltiplas
Placa Dentária/microbiologia
Fusobacterium/isolamento & purificação
Seres Humanos
Imunoglobulina E/sangue
Lactobacillus/isolamento & purificação
Leptotrichia/isolamento & purificação
Deformidades Congênitas dos Membros
Mucosa Bucal/microbiologia
Neutrófilos/citologia
Filogenia
Reação em Cadeia da Polimerase
RNA Ribossômico 16S/genética
Saliva/microbiologia
Streptococcus/isolamento & purificação
Anormalidades Dentárias
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28797303
[Au] Autor:Heyman L; Houri-Haddad Y; Heyman SN; Ginsburg I; Gleitman Y; Feuerstein O
[Ad] Endereço:Department of Prosthodontics, Hebrew University-Hadassah Faculty of Dental Medicine, P.O.B. 12272, 91120, Jerusalem, Israel.
[Ti] Título:Combined antioxidant effects of Neem extract, bacteria, red blood cells and Lysozyme: possible relation to periodontal disease.
[So] Source:BMC Complement Altern Med;17(1):399, 2017 Aug 10.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The common usage of chewing sticks prepared from Neem tree (Azadirachta indica) in India suggests its potential efficacy in periodontal diseases. The objective of this study is to explore the antibacterial effects of Neem leaf extract on the periodontophatic bacteria Porphyromonas gingivalis and Fusobacterium nucleatum, and its antioxidant capacities alone and in combination with bacteria and polycationic peptides that may be at the site of inflammation. METHODS: Neem leaf extract was prepared by ethanol extraction. The growth kinetics of P. gingivalis and F. nucleatum under anaerobic conditions in the presence of Neem leaf extract were measured. Broth microdilution test was used to determine the Minimal Inhibitory Concentration (MIC) of Neem leaf extract against each bacterial strain. The effect of Neem leaf extract on the coaggregation of the bacteria was assessed by a visual semi-quantitative assay. The antioxidant capacities of Neem leaf extract alone and in combination with bacteria, with the addition of red blood cells or the polycationic peptides chlorhexidine and lisozyme, were determined using a chemiluminescence assay. RESULTS: Neem leaf extract showed prominent dose-dependent antibacterial activity against P. gingivalis, however, had no effect on the growth of F. nucleatum nor on the coaggregation of the two bacteria. Yet, it showed intense antioxidant activity, which was amplified following adherence to bacteria and with the addition of red blood cells or the polycationic peptides. CONCLUSIONS: Neem leaf extract, containing polyphenols that adhere to oral surfaces, have the potential to provide long-lasting antibacterial as well as synergic antioxidant activities when in complex with bacteria, red blood cells and lisozyme. Thus, it might be especially effective in periodontal diseases.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antioxidantes/farmacologia
Azadirachta/química
Eritrócitos
Muramidase/metabolismo
Doenças Periodontais/microbiologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos Locais
Clorexidina
Fusobacterium/efeitos dos fármacos
Fusobacterium nucleatum/efeitos dos fármacos
Fusobacterium nucleatum/crescimento & desenvolvimento
Seres Humanos
Índia
Medicina Tradicional
Testes de Sensibilidade Microbiana
Peptídeos
Doenças Periodontais/tratamento farmacológico
Doenças Periodontais/metabolismo
Fitoterapia
Folhas de Planta
Poliaminas
Polifenóis/farmacologia
Porphyromonas/efeitos dos fármacos
Porphyromonas gingivalis/efeitos dos fármacos
Porphyromonas gingivalis/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents, Local); 0 (Antioxidants); 0 (Peptides); 0 (Plant Extracts); 0 (Polyamines); 0 (Polyphenols); 0 (polycations); EC 3.2.1.17 (Muramidase); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1900-3


  4 / 1339 MEDLINE  
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[PMID]:28792235
[Au] Autor:Pummer A; Knüttel H; Hiller KA; Buchalla W; Cieplik F; Maisch T
[Ad] Endereço:Department of Conservative Dentistry & Periodontology, University Medical Center Regensburg, 93053 Regensburg, Germany.
[Ti] Título:Antimicrobial efficacy of irradiation with visible light on oral bacteria in vitro: a systematic review.
[So] Source:Future Med Chem;9(13):1557-1574, 2017 Sep.
[Is] ISSN:1756-8927
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: Resistances to antibiotics employed for treatment of infectious diseases have increased to alarming numbers making it more and more difficult to treat diseases caused by microorganisms resistant to common antibiotics. Consequently, novel methods for successful inactivation of pathogens are required. In this instance, one alternative could be application of light for treatment of topical infections. Antimicrobial properties of UV light are well documented, but due to its DNA-damaging properties use for medical purposes is limited. In contrast, irradiation with visible light may be more promising. METHODS: Literature was systematically screened for research concerning inactivation of main oral bacterial species by means of visible light. RESULTS: Inactivation of bacterial species, especially pigmented ones, in planktonic state showed promising results. There is a lack of research examining the situation when organized as biofilms. CONCLUSION: More research concerning situation in a biofilm state is required.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Bactérias/efeitos dos fármacos
Luz
[Mh] Termos MeSH secundário: Aggregatibacter/efeitos dos fármacos
Aggregatibacter/efeitos da radiação
Anti-Infecciosos/química
Bactérias/efeitos da radiação
Escherichia coli/efeitos dos fármacos
Escherichia coli/efeitos da radiação
Fusobacterium/efeitos dos fármacos
Fusobacterium/efeitos da radiação
Seres Humanos
Boca/microbiologia
Porphyromonas/efeitos dos fármacos
Porphyromonas/efeitos da radiação
Prevotella/efeitos dos fármacos
Prevotella/efeitos da radiação
Staphylococcus/efeitos dos fármacos
Staphylococcus/efeitos da radiação
Streptococcus/efeitos dos fármacos
Streptococcus/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.4155/fmc-2017-0051


  5 / 1339 MEDLINE  
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[PMID]:28771533
[Au] Autor:Abdi K; Chen T; Klein BA; Tai AK; Coursen J; Liu X; Skinner J; Periasamy S; Choi Y; Kessler BM; Palmer RJ; Gittis A; Matzinger P; Duncan MJ; Singh NJ
[Ad] Endereço:Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, Maryland, United States of America.
[Ti] Título:Mechanisms by which Porphyromonas gingivalis evades innate immunity.
[So] Source:PLoS One;12(8):e0182164, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The oral cavity is home to unique resident microbial communities whose interactions with host immunity are less frequently studied than those of the intestinal microbiome. We examined the stimulatory capacity and the interactions of two oral bacteria, Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum), on Dendritic Cell (DC) activation, comparing them to the effects of the well-studied intestinal microbe Escherichia coli (E. coli). Unlike F. nucleatum and E. coli, P. gingivalis failed to activate DCs, and in fact silenced DC responses induced by F. nucleatum or E. coli. We identified a variant strain of P. gingivalis (W50) that lacked this immunomodulatory activity. Using biochemical approaches and whole genome sequencing to compare the two substrains, we found a point mutation in the hagA gene. This protein is though to be involved in the alteration of the PorSS/gingipain pathway, which regulates protein secretion into the extracellular environment. A proteomic comparison of the secreted products of the two substrains revealed enzymatic differences corresponding to this phenotype. We found that P. gingivalis secretes gingipain(s) that inactivate several key proinflammatory mediators made by DCs and/or T cells, but spare Interleukin-1 (IL-1) and GM-CSF, which can cause capillary leaks that serve as a source of the heme that P. gingivalis requires for its survival, and GM-CSF, which can cause epithelial-cell growth. Taken together, our results suggest that P. gingivalis has evolved potent mechanisms to modulate its virulence factors and dampen the innate immune response by selectively inactivating most proinflammatory cytokines.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Interações Hospedeiro-Patógeno/imunologia
Imunidade Inata
Porphyromonas gingivalis/imunologia
[Mh] Termos MeSH secundário: Animais
Antibiose
Proteínas de Bactérias/química
Proteínas de Bactérias/metabolismo
Citocinas/análise
Citocinas/metabolismo
DNA Bacteriano/química
DNA Bacteriano/isolamento & purificação
DNA Bacteriano/metabolismo
Células Dendríticas/imunologia
Células Dendríticas/metabolismo
Células Dendríticas/microbiologia
Escherichia coli/genética
Feminino
Fusobacterium/fisiologia
Fator Estimulador de Colônias de Granulócitos e Macrófagos/análise
Fator Estimulador de Colônias de Granulócitos e Macrófagos/metabolismo
Seres Humanos
Mediadores da Inflamação/metabolismo
Interleucina-1/análise
Interleucina-1/metabolismo
Lectinas/química
Lectinas/genética
Lectinas/metabolismo
Masculino
Camundongos
Camundongos Transgênicos
Porphyromonas gingivalis/genética
Linfócitos T/imunologia
Linfócitos T/metabolismo
Linfócitos T/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Cytokines); 0 (DNA, Bacterial); 0 (Inflammation Mediators); 0 (Interleukin-1); 0 (Lectins); 0 (hemagglutinin A, Porphyromonas gingivalis); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182164


  6 / 1339 MEDLINE  
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[PMID]:28760931
[Au] Autor:Shen P; Whelan FJ; Schenck LP; McGrath JJC; Vanderstocken G; Bowdish DME; Surette MG; Stämpfli MR
[Ad] Endereço:Medical Sciences Graduate Program, McMaster University, Hamilton, Ontario, Canada.
[Ti] Título:Streptococcus pneumoniae Colonization Is Required To Alter the Nasal Microbiota in Cigarette Smoke-Exposed Mice.
[So] Source:Infect Immun;85(10), 2017 Oct.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Smokers have nasal microbiota dysbiosis, with an increased frequency of colonizing bacterial pathogens. It is possible that cigarette smoke increases pathogen acquisition by perturbing the microbiota and decreasing colonization resistance. However, it is difficult to disentangle microbiota dysbiosis due to cigarette smoke exposure from microbiota changes caused by increased pathogen acquisition in human smokers. Using an experimental mouse model, we investigated the impact of cigarette smoke on the nasal microbiota in the absence and presence of nasal pneumococcal colonization. We observed that cigarette smoke exposure alone did not alter the nasal microbiota composition. The microbiota composition was also unchanged at 12 h following low-dose nasal pneumococcal inoculation, suggesting that the ability of the microbiota to resist initial nasal pneumococcal acquisition was not impaired in smoke-exposed mice. However, nasal microbiota dysbiosis occurred as a consequence of established high-dose nasal pneumococcal colonization at day 3 in smoke-exposed mice. Similar to clinical reports on human smokers, an enrichment of potentially pathogenic bacterial genera such as , , and was observed. Our findings suggest that cigarette smoke exposure predisposes to pneumococcal colonization independent of changes to the nasal microbiota and that microbiota dysbiosis observed in smokers may occur as a consequence of established pathogen colonization.
[Mh] Termos MeSH primário: Microbiota/efeitos dos fármacos
Nariz/microbiologia
Fumaça/efeitos adversos
Streptococcus pneumoniae/fisiologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Disbiose
Fusobacterium/isolamento & purificação
Gemella/isolamento & purificação
Seres Humanos
Pulmão/microbiologia
Camundongos
Neisseria/isolamento & purificação
Infecções Pneumocócicas/microbiologia
Pneumonia/microbiologia
Produtos do Tabaco/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE


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[PMID]:28628112
[Au] Autor:Liu R; Hong J; Xu X; Feng Q; Zhang D; Gu Y; Shi J; Zhao S; Liu W; Wang X; Xia H; Liu Z; Cui B; Liang P; Xi L; Jin J; Ying X; Wang X; Zhao X; Li W; Jia H; Lan Z; Li F; Wang R; Sun Y; Yang M; Shen Y; Jie Z; Li J; Chen X; Zhong H; Xie H; Zhang Y; Gu W; Deng X; Shen B; Xu X; Yang H; Xu G; Bi Y; Lai S; Wang J; Qi L; Madsen L; Wang J; Ning G; Kristiansen K; Wang W
[Ad] Endereço:State Key Laboratory of Medical Genomes, National Clinical Research Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
[Ti] Título:Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention.
[So] Source:Nat Med;23(7):859-868, 2017 Jul.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.
[Mh] Termos MeSH primário: DNA Bacteriano/análise
Disbiose/microbiologia
Microbioma Gastrointestinal/genética
Metaboloma
Obesidade/microbiologia
[Mh] Termos MeSH secundário: Adiposidade
Adulto
Animais
Bacteroides/genética
Bacteroides thetaiotaomicron/genética
Cirurgia Bariátrica
Estudos de Casos e Controles
Disbiose/metabolismo
Feminino
Fusobacterium/genética
Gastrectomia
Ácido Glutâmico/sangue
Seres Humanos
Masculino
Metagenoma
Camundongos
Obesidade/metabolismo
Obesidade/cirurgia
Ganho de Peso
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 3KX376GY7L (Glutamic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4358


  8 / 1339 MEDLINE  
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[PMID]:28582482
[Au] Autor:Amitay EL; Werner S; Vital M; Pieper DH; Höfler D; Gierse IJ; Butt J; Balavarca Y; Cuk K; Brenner H
[Ad] Endereço:Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany.
[Ti] Título:Fusobacterium and colorectal cancer: causal factor or passenger? Results from a large colorectal cancer screening study.
[So] Source:Carcinogenesis;38(8):781-788, 2017 Aug 01.
[Is] ISSN:1460-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Colorectal cancer is a leading cause of morbidity and mortality worldwide in both men and women. The gut microbiome is increasingly recognized as having an important role in human health and disease. Fusobacterium has been identified in former studies as a leading gut bacterium associated with colorectal cancer, but it is still not clear if it plays an oncogenic role. In the current study, fecal samples were collected prior to bowel preparation from participants of screening colonoscopy in the German BliTz study. Using 16S rRNA gene analysis, we examined the presence and relative abundance of Fusobacterium in fecal samples from 500 participants, including 46, 113, 110 and 231 individuals with colorectal cancer, advanced adenomas, non-advanced adenomas and without any neoplasms, respectively. We found that the abundance of Fusobacterium in feces was strongly associated with the presence of colorectal cancer (P-value < 0.0001). This was confirmed by PCR at the species level for Fusobacterium nucleatum. However, no association was seen with the presence of advanced adenomas (P-value = 0.80) or non-advanced adenomas (P-value = 0.80), nor were there any associations observed with dietary or lifestyle habits. Although a causal role cannot be ruled out, our observations, based on fecal microbiome, support the hypothesis that Fusobacterium is a passenger that multiplies in the more favorable conditions caused by the malignant tumor rather than a causal factor in colorectal cancer development.
[Mh] Termos MeSH primário: Neoplasias Colorretais/microbiologia
Fusobacterium/isolamento & purificação
Microbioma Gastrointestinal/genética
[Mh] Termos MeSH secundário: Idoso
Neoplasias Colorretais/genética
Neoplasias Colorretais/patologia
Detecção Precoce de Câncer
Fezes/microbiologia
Feminino
Fusobacterium/genética
Fusobacterium/patogenicidade
Seres Humanos
Masculino
Meia-Idade
RNA Ribossômico 16S/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1093/carcin/bgx053


  9 / 1339 MEDLINE  
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[PMID]:28576541
[Au] Autor:Benadjaoud Y; Klopp-Dutote N; Choquet M; Brunel E; Guiheneuf R; Page C
[Ad] Endereço:Department of Paediatrics, University Hospital, Amiens, France.
[Ti] Título:A case of acute clival osteomyelitis in a 7-year-old boy secondary to infection of a Thornwaldt cyst.
[So] Source:Int J Pediatr Otorhinolaryngol;95:87-90, 2017 Apr.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Clival osteomyelitis is a potentially life-threatening infection that can occur in healthy children. It can be related to congenital anomalies. We report the case of a 7-year-old boy with Streptococcus intermedius and Fusobacterium clival osteomyelitis arising from a Thornwaldt cyst situated in a fossa navicularis magna of the occipital bone. Multidisciplinary management is necessary to ensure rapid improvement and complete healing.
[Mh] Termos MeSH primário: Fossa Craniana Posterior/patologia
Cistos/complicações
Infecções por Fusobacterium/complicações
Nasofaringe/patologia
Osso Occipital/patologia
Osteomielite/etiologia
Infecções Estreptocócicas/complicações
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Criança
Fusobacterium/isolamento & purificação
Infecções por Fusobacterium/tratamento farmacológico
Seres Humanos
Masculino
Infecções Estreptocócicas/tratamento farmacológico
Streptococcus intermedius/isolamento & purificação
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE


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[PMID]:28498878
[Au] Autor:Michl SC; Ratten JM; Beyer M; Hasler M; LaRoche J; Schulz C
[Ad] Endereço:Gesellschaft für Marine Aquakultur mbH (GMA) Büsum, Büsum, Germany.
[Ti] Título:The malleable gut microbiome of juvenile rainbow trout (Oncorhynchus mykiss): Diet-dependent shifts of bacterial community structures.
[So] Source:PLoS One;12(5):e0177735, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plant-derived protein sources are the most relevant substitutes for fishmeal in aquafeeds. Nevertheless, the effects of plant based diets on the intestinal microbiome especially of juvenile Rainbow trout (Oncorhynchus mykiss) are yet to be fully investigated. The present study demonstrates, based on 16S rDNA bacterial community profiling, that the intestinal microbiome of juvenile Rainbow trout is strongly affected by dietary plant protein inclusion levels. After first feeding of juveniles with either 0%, 50% or 97% of total dietary protein content derived from plants, statistically significant differences of the bacterial gut community for the three diet-types were detected, both at phylum and order level. The microbiome of juvenile fish consisted mainly of the phyla Proteobacteria, Firmicutes, Bacteroidetes, Fusobacteria and Actinobacteria, and thus fits the salmonid core microbiome suggested in previous studies. Dietary plant proteins significantly enhanced the relative abundance of the orders Lactobacillales, Bacillales and Pseudomonadales. Animal proteins in contrast significantly promoted Bacteroidales, Clostridiales, Vibrionales, Fusobacteriales and Alteromonadales. The overall alpha diversity significantly decreased with increasing plant protein inclusion levels and with age of experimental animals. In order to investigate permanent effects of the first feeding diet-type on the early development of the microbiome, a diet change was included in the study after 54 days, but no such effects could be detected. Instead, the microbiome of juvenile trout fry was highly dependent on the actual diet fed at the time of sampling.
[Mh] Termos MeSH primário: Microbioma Gastrointestinal/fisiologia
Oncorhynchus mykiss/microbiologia
[Mh] Termos MeSH secundário: Alteromonadaceae/genética
Alteromonadaceae/isolamento & purificação
Ração Animal
Animais
Bacillales/genética
Bacillales/isolamento & purificação
Bacteroides/genética
Bacteroides/isolamento & purificação
Clostridiales/genética
Clostridiales/isolamento & purificação
DNA Ribossômico/genética
Dieta
Fusobacterium/genética
Fusobacterium/isolamento & purificação
Microbioma Gastrointestinal/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177735



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