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[PMID]:28599639
[Au] Autor:Psoter KJ; De Roos AJ; Wakefield J; Mayer JD; Rosenfeld M
[Ad] Endereço:Department of Pediatrics, School of Medicine, The Johns Hopkins University Bayview Medical Center, 5200 Eastern Ave, Mason F. Lord Bldg, Suite 4200, Baltimore, MD, 21224, USA. kpsoter1@jhu.edu.
[Ti] Título:Seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis.
[So] Source:BMC Infect Dis;17(1):411, 2017 Jun 09.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Seasonal variations are often observed for respiratory tract infections; however, limited information is available regarding seasonal patterns of acquisition of common cystic fibrosis (CF)-related respiratory pathogens. We previously reported differential seasonal acquisition of Pseudomonas aeruginosa in young children with CF and no such variation for methicillin-susceptible Staphylococcus aureus acquisition. The purpose of this study was to describe and compare the seasonal incidence of acquisition of other respiratory bacterial pathogens in young children with CF. METHODS: We conducted a retrospective study to describe and compare the seasonal incidence of methicillin-resistant Staphylococcus aureus (MRSA), Stenotrophomonas maltophilia, Achromobacter xylosoxidans, and Haemophilus influenzae acquisition in young CF patients residing in the U.S. using the Cystic Fibrosis Foundation National Patient Registry, 2003-2009. Log-linear overdispersed Poisson regression was used to evaluate seasonal acquisition of each of these pathogens. RESULTS: A total of 4552 children met inclusion criteria. During follow-up 910 (20%), 1161 (26%), 228 (5%), and 2148 (47%) children acquired MRSA, S. maltophilia, A. xylosoxidans and H. influenzae, respectively. Compared to winter season, MRSA was less frequently acquired in spring (Incidence Rate Ratio [IRR]: 0.79; 95% Confidence Interval [CI]: 0.65, 0.96) and summer (IRR: 0.69; 95% CI: 0.57, 0.84) seasons. Similarly, a lower rate of A. xylosoxidans acquisition was observed in spring (IRR: 0.59; 95% CI: 0.39, 0.89). For H. influenzae, summer (IRR: 0.88; 95% CI: 0.78, 0.99) and autumn (IRR: 0.78; 95% CI: 0.69, 0.88) seasons were associated with lower acquisition rates compared to winter. No seasonal variation was observed for S. maltophilia acquisition. CONCLUSION: Acquisition of CF-related respiratory pathogens displays seasonal variation in young children with CF, with the highest rate of acquisition for most pathogens occurring in the winter. Investigation of factors underlying these observed associations may contribute to our understanding of the aetiology of these infections and guide future infection control strategies.
[Mh] Termos MeSH primário: Fibrose Cística/microbiologia
Infecções Respiratórias/epidemiologia
Infecções Respiratórias/microbiologia
[Mh] Termos MeSH secundário: Achromobacter denitrificans/isolamento & purificação
Achromobacter denitrificans/patogenicidade
Pré-Escolar
Clima
Fibrose Cística/complicações
Feminino
Infecções por Haemophilus/epidemiologia
Infecções por Haemophilus/microbiologia
Haemophilus influenzae/isolamento & purificação
Haemophilus influenzae/patogenicidade
Seres Humanos
Masculino
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Staphylococcus aureus Resistente à Meticilina/patogenicidade
Infecções por Pseudomonas/epidemiologia
Infecções por Pseudomonas/microbiologia
Pseudomonas aeruginosa/isolamento & purificação
Pseudomonas aeruginosa/patogenicidade
Estudos Retrospectivos
Estações do Ano
Infecções Estafilocócicas/epidemiologia
Infecções Estafilocócicas/microbiologia
Staphylococcus aureus/isolamento & purificação
Staphylococcus aureus/patogenicidade
Stenotrophomonas maltophilia/isolamento & purificação
Stenotrophomonas maltophilia/patogenicidade
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2511-9


  2 / 200 MEDLINE  
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[PMID]:28422870
[Au] Autor:Tsai JL; Tsai SF
[Ad] Endereço:aDepartment of Family Medicine, Cheng Ching General Hospital bDivision of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital cDepartment of Life Science, Tunghai University, Taichung dDepartment of Medicine, Nation Yang Ming University, Taipei, Taiwan.
[Ti] Título:Case report: The first case of Achromobacter xylosoxidans-related tunnel infection in a patient receiving peritoneal dialysis.
[So] Source:Medicine (Baltimore);96(16):e6654, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Achromobacter xylosoxidans infection is mostly reported in immunocompromised patients. Until now, it is still rarely reported in patients undergoing peritoneal dialysis. PATIENT CONCERNS: This is the 1st case of A xylosoxidans infection due to tunnel infection of a Tenckhoff catheter. DIAGNOSIS: The diagnosis was confirmed by the report of culture. INTERVENTIONS: Risk factors for this infection in peritoneal dialysis include uremia with an immunocompromised state, contamination due to inexperienced skills, and aqueous environment of the dialysate. OUTCOME: We believe that finding the source of A xylosoxidans contamination is the most important aspect of the overall treatment of the infection. LESSONS: Environmental investigation of suspected source contamination is warranted in those with A xylosoxidans infection. Once the diagnosis is made, removal of the Tenckhoff catheter should not be delayed.
[Mh] Termos MeSH primário: Achromobacter denitrificans
Infecções Relacionadas a Cateter/diagnóstico
Infecções por Bactérias Gram-Negativas/diagnóstico
Diálise Peritoneal/efeitos adversos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Hospedeiro Imunocomprometido
Meia-Idade
Fatores de Risco
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006654


  3 / 200 MEDLINE  
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[PMID]:28285343
[Au] Autor:Nguyen PY; Carvalho G; Reis AC; Nunes OC; Reis MAM; Oehmen A
[Ad] Endereço:UCIBIO, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, 2829-516, Lisbon, Portugal.
[Ti] Título:Impact of biogenic substrates on sulfamethoxazole biodegradation kinetics by Achromobacter denitrificans strain PR1.
[So] Source:Biodegradation;28(2-3):205-217, 2017 Jun.
[Is] ISSN:1572-9729
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Pure cultures have been found to degrade pharmaceutical compounds. However, these cultures are rarely characterized kinetically at environmentally relevant concentrations. This study investigated the kinetics of sulfamethoxazole (SMX) degradation by Achromobacter denitrificans strain PR1 at a wide range of concentrations, from ng/L to mg/L, to assess the feasibility of using it for bioaugmentation purposes. Complete removal of SMX occurred for all concentrations tested, i.e., 150 mg/L, 500 µg/L, 20 µg/L, and 600 ng/L. The reaction rate coefficients (k ) for the strain at the ng/L SMX range were: 63.4 ± 8.6, 570.1 ± 15.1 and 414.9 ± 124.2 L/g[Formula: see text]·day), for tests fed without a supplemental carbon source, with acetate, and with succinate, respectively. These results were significantly higher than the value reported for non-augmented activated sludge (0.41 L/(g [Formula: see text]·day) with hundreds of ng/L of SMX. The simultaneous consumption of an additional carbon source and SMX suggested that the energetic efficiency of the cells, boosted by the presence of biogenic substrates, was important in increasing the SMX degradation rate. The accumulation of 3-amino-5-methylisoxazole was observed as the only metabolite, which was found to be non-toxic. SMX inhibited the Vibrio fischeri luminescence after 5 min of contact, with EC values of about 53 mg/L. However, this study suggested that the strain PR1 still can degrade SMX up to 150 mg/L. The results of this work demonstrated that SMX degradation kinetics by A. denitrificans PR1 compares favorably with activated sludge and the strain is a potentially interesting organism for bioaugmentation for SMX removal from polluted waters.
[Mh] Termos MeSH primário: Achromobacter denitrificans/metabolismo
Sulfametoxazol/metabolismo
[Mh] Termos MeSH secundário: Achromobacter denitrificans/efeitos dos fármacos
Achromobacter denitrificans/crescimento & desenvolvimento
Biodegradação Ambiental/efeitos dos fármacos
Biomassa
Carbono/metabolismo
Cinética
Metaboloma/efeitos dos fármacos
Modelos Biológicos
Especificidade por Substrato/efeitos dos fármacos
Sulfametoxazol/toxicidade
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 7440-44-0 (Carbon); JE42381TNV (Sulfamethoxazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE
[do] DOI:10.1007/s10532-017-9789-6


  4 / 200 MEDLINE  
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[PMID]:28141585
[Au] Autor:Liu C; Guo J; Yan W; Jin Y; Pan F; Fang X; Qin L; Liu C
[Ad] Endereço:Beijing Haidian Hospital, Beijing Haidian Section of Peking University Third Hospital, Beijing, China. liuchao3619@163.com.
[Ti] Título:Hospital-acquired pneumonia due to Achromobacter xylosoxidans in the elderly: A single-center retrospective study in Beijing.
[So] Source:J Infect Dev Ctries;11(1):10-18, 2017 Jan 30.
[Is] ISSN:1972-2680
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Achromobacter xylosoxidans has been reported in several countries; however, hospital-acquired pneumonia (HAP) due to this organism in elderly patients in China remains rare. METHODOLOGY: HAP due to Achromobacter xylosoxidans identified at the General Hospital of the People's Liberation Army in Beijing from January 2008 to October 2011 was studied. Detailed clinical manifestations were collected. To study the clinical risk factors for the imipenem-resistant strain, patients were divided into two groups: imipenem-resistant (21 cases) and imipenem-nonresistant (20 cases). Univariate and multivariate logistic regression were used. RESULTS: All patients were > 75 years of age, and 92.7% (38/41) were male. Nine patients died 30 days after infection. The mean acute physiology and chronic health evaluation (APACHE) II score and sequential organ failure assessment (SOFA) were 23.66 ± 7.71 and 6.93 ± 2.47, respectively. Almost all strains were resistant to aminoglycosides. However, the strains showed significant sensitivity to minocycline (MIN), piperacillin-tazobactam (PTZ), and cefoperazone-sulbactam (SCF). Compared with the imipenem-nonresistant group, more patients with imipenem-resistant infection had the following characteristics: use of an intubation, use of a proton-pump inhibitor (PPI), chronic obstructive pulmonary disease (COPD), and coronary artery disease (CHD). Among the four risk factors, COPD and CHD remained independent risk factors in the multivariate analysis. CONCLUSIONS: HAP due to Achromobacter xylosoxidans occurred in severely ill elderly patients with a long-term indwelling catheter and many underlying diseases. Effective treatment of imipenem-resistant organisms is challenging. SCF, PTZ, and MIN may be useful for imipenem-resistant Achromobacter xylosoxidans.
[Mh] Termos MeSH primário: Achromobacter denitrificans/isolamento & purificação
Infecção Hospitalar/epidemiologia
Infecções por Bactérias Gram-Negativas/epidemiologia
Pneumonia Bacteriana/epidemiologia
Resistência beta-Lactâmica
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Pequim/epidemiologia
Cateteres de Demora
Infecção Hospitalar/microbiologia
Infecção Hospitalar/patologia
Feminino
Infecções por Bactérias Gram-Negativas/microbiologia
Infecções por Bactérias Gram-Negativas/patologia
Hospitais Gerais
Hospitais de Veteranos
Seres Humanos
Imipenem/farmacologia
Masculino
Pneumonia Bacteriana/microbiologia
Pneumonia Bacteriana/patologia
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 71OTZ9ZE0A (Imipenem)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.3855/jidc.8747


  5 / 200 MEDLINE  
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[PMID]:28096165
[Au] Autor:Grohs P; Taieb G; Morand P; Kaibi I; Podglajen I; Lavollay M; Mainardi JL; Compain F
[Ad] Endereço:Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
[Ti] Título: Activity of Ceftolozane-Tazobactam against Multidrug-Resistant Nonfermenting Gram-Negative Bacilli Isolated from Patients with Cystic Fibrosis.
[So] Source:Antimicrob Agents Chemother;61(4), 2017 Apr.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ceftolozane-tazobactam was tested against 58 multidrug-resistant nonfermenting Gram-negative bacilli (35 , 11 , and 12 isolates) isolated from cystic fibrosis patients and was compared to ceftolozane alone, ceftazidime, meropenem, and piperacillin-tazobactam. Ceftolozane-tazobactam was the most active agent against but was inactive against and In time-kill experiments, ceftolozane-tazobactam had complete bactericidal activity against 2/6 clinical isolates (33%).
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Cefalosporinas/farmacologia
[Mh] Termos MeSH secundário: Achromobacter denitrificans/efeitos dos fármacos
Ceftazidima/farmacologia
Fibrose Cística/microbiologia
Farmacorresistência Bacteriana Múltipla/genética
Bactérias Gram-Negativas/efeitos dos fármacos
Seres Humanos
Testes de Sensibilidade Microbiana
Ácido Penicilânico/análogos & derivados
Ácido Penicilânico/farmacologia
Piperacilina/farmacologia
Pseudomonas aeruginosa/efeitos dos fármacos
Stenotrophomonas maltophilia/efeitos dos fármacos
Tienamicinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cephalosporins); 0 (Thienamycins); 157044-21-8 (piperacillin, tazobactam drug combination); 37A4IES95Q (ceftolozane); 87-53-6 (Penicillanic Acid); 9M416Z9QNR (Ceftazidime); FV9J3JU8B1 (meropenem); SE10G96M8W (tazobactam); X00B0D5O0E (Piperacillin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE


  6 / 200 MEDLINE  
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[PMID]:27660099
[Au] Autor:Padhi SK; Maiti NK
[Ad] Endereço:Environmental Microbiology Group, Fish Health Management Division, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar 751002, Odisha, India.
[Ti] Título:Molecular insight into the dynamic central metabolic pathways of Achromobacter xylosoxidans CF-S36 during heterotrophic nitrogen removal processes.
[So] Source:J Biosci Bioeng;123(1):46-55, 2017 Jan.
[Is] ISSN:1347-4421
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Organic carbon sources play a significant role in heterotrophic nitrogen consumption. This quintessential exploration is focused on carbon and nitrogen biogeochemical cycles in heterotrophic bacteria, capable of simultaneous nitrification and denitrification (SND). A heterotrophic bacterial strain Achromobacter xylosoxidans CF-S36 isolated from domestic wastewater efficiently eliminated ammonia, nitrate and nitrite by utilizing different carbon sources. The type of carbon utilized by strain CF-S36 determined the rate of heterotrophic nitrogen removal. Quantitative real-time PCR (qRT-PCR) analysis of genes of central carbon and nitrogen metabolism, signal transduction, electron transport chain (ETC) pathways and assays of enzymes of denitrification processes revealed the existence of well-coordinated link between carbon utilization and nitrogen elimination in bacterial cell. The most preferred carbon source for nitrification was succinate followed by glucose and acetate. Inhibitory effect of nitrite on glycolytic pathway and nitrogen assimilation genes attributes glucose as unfavorable carbon source for denitrification process in strain CF-S36. Acetate served as efficient carbon source for utilizing nitrite through denitrification process. The study demonstrated here might be useful to biogeochemical engineer to understand the involvement of heterotrophic bacteria in global biogeochemical cycle and to gain further insight into the diversified application of these microorganisms.
[Mh] Termos MeSH primário: Achromobacter denitrificans/metabolismo
Processos Heterotróficos
Nitrogênio/isolamento & purificação
Nitrogênio/metabolismo
[Mh] Termos MeSH secundário: Achromobacter denitrificans/crescimento & desenvolvimento
Aerobiose
Carbono/metabolismo
Desnitrificação
Nitratos/metabolismo
Nitrificação
Nitritos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrates); 0 (Nitrites); 7440-44-0 (Carbon); N762921K75 (Nitrogen)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE


  7 / 200 MEDLINE  
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[PMID]:27756240
[Au] Autor:Günther F; Merle U; Frank U; Gaida MM; Mutters NT
[Ad] Endereço:Department of Infectious Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 324, D-69120, Heidelberg, Germany.
[Ti] Título:Pseudobacteremia outbreak of biofilm-forming Achromobacter xylosoxidans - environmental transmission.
[So] Source:BMC Infect Dis;16(1):584, 2016 Oct 19.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Achromobacter xylosoxidans (AX) is known for intrinsic resistance to disinfectants. Our laboratory routine surveillance system detected an unexpected rise in AX bloodstream infections in a 2200-bed hospital. An epidemiological investigation was conducted to find the source and disrupt further transmission. METHODS: Outbreak cases were defined as patients with at least one positive blood culture positive for AX from May 2014 to May 2015. Medical records were reviewed, affected wards, as well as the microbiology laboratory were audited. Additionally, microbiologic culture and biofilm staining for suspected antiseptic reusable tissue dispensers were performed, and isolated AX strains were typed using RAPD PCR and PFGE. RESULTS: During the outbreak period, AX were isolated from blood cultures from 26 patients. The retrospective cohort study did not reveal common risk factors. The clinical features of the case patients suggested a pseudobacteremia. The reusable tissue dispensers containing Incidin® Plus solution product were found to be contaminated with biofilm-forming AX. Typing of the isolates revealed that blood culture isolates were identical with the strains found in the dispensers. CONCLUSIONS: After changing the usage of the product to single-use and educating staff, the outbreak was terminated. Contamination of dispensers occurred due to insufficient reprocessing, since biofilm disrupting steps were not included in the process.
[Mh] Termos MeSH primário: Achromobacter denitrificans/patogenicidade
Infecções por Bactérias Gram-Negativas/epidemiologia
[Mh] Termos MeSH secundário: Achromobacter denitrificans/isolamento & purificação
Achromobacter denitrificans/fisiologia
Biofilmes
Surtos de Doenças
Desinfetantes/farmacologia
Alemanha/epidemiologia
Hospitais
Seres Humanos
Técnica de Amplificação ao Acaso de DNA Polimórfico
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE


  8 / 200 MEDLINE  
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[PMID]:27544979
[Au] Autor:Nakamoto S; Goda N; Hayabuchi T; Tamaki H; Ishida A; Suzuki A; Nakano K; Yui S; Katsumata Y; Yamagami Y; Burioka N; Chikumi H; Shimizu E
[Ti] Título:Properties of Achromobacter xylosoxidans highly resistant to aminoglycoside antibiotics.
[So] Source:Jpn J Antibiot;69(2):113-8, 2016 Apr.
[Is] ISSN:0368-2781
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We herein discovered a highly resistant clinical isolate of Pseudomonas aeruginosa with MICs to amikacin, gentamicin, and arbekacin of 128 µg/mL or higher in a drug sensitivity survey of 92 strains isolated from the specimens of Yoka hospital patients between January 2009 and October 2010, and Achromobacter xylosoxidans was separated from this P. aeruginosa isolate. The sensitivity of this bacterium to 29 antibiotics was investigated. The MICs of this A. xylosoxidans strain to 9 aminoglycoside antibiotics were: amikacin, gentamicin, arbekacin, streptomycin, kanamycin, neomycin, and spectinomycin, 1,024 µg/mL or ≥ 1,024 µg/mL; netilmicin, 512 µg/mL; and tobramycin, 256 µg/mL. This strain was also resistant to dibekacin. This aminoglycoside antibiotic resistant phenotype is very rare, and we are the first report the emergence of A. xylosoxidans with this characteristic.
[Mh] Termos MeSH primário: Achromobacter denitrificans/efeitos dos fármacos
Aminoglicosídeos/farmacologia
Antibacterianos/farmacologia
Farmacorresistência Bacteriana
[Mh] Termos MeSH secundário: Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aminoglycosides); 0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161116
[Lr] Data última revisão:
161116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE


  9 / 200 MEDLINE  
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[PMID]:27498677
[Au] Autor:Stobbelaar K; Van Hoorenbeeck K; Lequesne M; De Dooy J; Ho E; Vlieghe E; Ieven M; Verhulst S
[Ad] Endereço:Department of Pediatric Pulmonology, Antwerp University Hospital, Edegem, Belgium.
[Ti] Título:Sepsis Caused by Achromobacter Xylosoxidans in a Child with Cystic Fibrosis and Severe Lung Disease.
[So] Source:Am J Case Rep;17:562-6, 2016 Aug 08.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Achromobacter xylosoxidans is an aerobic, motile, Gram-negative, opportunistic pathogen that can be responsible for various severe nosocomial and community-acquired infections. It has been found in immunocompromised patients and patients with several other underlying conditions, but the clinical role of this microorganism in cystic fibrosis is unclear. CASE REPORT We describe a case of septic shock caused by A. xylosoxidans in a 10-year-old child with cystic fibrosis and severe lung disease. CONCLUSIONS As the prevalence of A. xylosoxidans in cystic fibrosis patients is rising and patient-to-patient transmission is highly probable, further studies are warranted to determine its role and to document the appropriate treatment strategy for eradication and long-term treatment of this organism.
[Mh] Termos MeSH primário: Achromobacter denitrificans
Fibrose Cística/complicações
Infecções por Bactérias Gram-Negativas/complicações
Insuficiência Respiratória/microbiologia
Sepse/microbiologia
[Mh] Termos MeSH secundário: Criança
Feminino
Infecções por Bactérias Gram-Negativas/diagnóstico
Infecções por Bactérias Gram-Negativas/tratamento farmacológico
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160809
[St] Status:MEDLINE


  10 / 200 MEDLINE  
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[PMID]:27470246
[Au] Autor:Khalid S; Hashmi I; Jamal Khan S; Qazi IA; Nasir H
[Ad] Endereço:Institute of Environmental Sciences and Engineering, School of Civil and Environmental Engineering, National University of Sciences and Technology (NUST), H-12, Islamabad, 44000, Pakistan. saira@iese.nust.edu.pk.
[Ti] Título:Effect of metal ions and petrochemicals on bioremediation of chlorpyrifos in aerobic sequencing batch bioreactor (ASBR).
[So] Source:Environ Sci Pollut Res Int;23(20):20646-20660, 2016 Oct.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Application of chlorpyrifos (CP) has increased its environmental concentration. Increasing CP concentration has increased chances of adverse health effects. Its removal from environment has attained researcher's attention. CP degrading bacterial strains were isolated from wastewater and agricultural soil. Finally, selected five bacterial strains were identified using 16S rRNA nucleotide sequence analysis as Pseudomonas kilonensis SRK1, Serratia marcescens SRK2, Bacillus pumilus SRK4, Achromobacter xylosoxidans SRK5, and Klebsiella sp. T13. Interaction studies among bacterial strains demonstrated possibility for development of five membered bacterial consortium. Biodegradation potential of bacterial consortium was investigated in the presence of petrochemicals and trace metals. About 98 % CP removal was observed in sequencing batch reactors at inoculum level, 10 %; pH, 7; CP concentration, 400 mgL , and HRT, 48 h. Experimental data has shown an excellent fit to first order growth model. Among all petrochemicals only toluene (in low concentration) has stimulatory effect on biodegradation of CP. Addition of petrochemicals (benzene, toluene, and xylene) in high concentration (100 mg L ) inhibited bacterial activity and decreased CP removal. At low concentration i.e., 1 mg L of inorganic contaminants (Cu, Hg, and Zn) >96 % degradation was observed. Addition of Cu(II) in low concentration has stimulated CP removal efficiency. Hg(II) in all concentrations has strongly inhibited biodegradation rate except at 1 mgL . In simulated pesticide, wastewater CP removal efficiency decreased to 77.5 %. Outcomes of study showed that both type and concentration of petrochemicals and trace metals influenced biodegradation of CP.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Clorpirifos/metabolismo
Praguicidas/metabolismo
Tolueno/farmacologia
[Mh] Termos MeSH secundário: Achromobacter denitrificans/efeitos dos fármacos
Achromobacter denitrificans/genética
Achromobacter denitrificans/metabolismo
Aerobiose
Bacillus pumilus/efeitos dos fármacos
Bacillus pumilus/genética
Bacillus pumilus/metabolismo
Técnicas de Cultura Celular por Lotes
Reatores Biológicos/microbiologia
Cobre/farmacologia
Klebsiella/efeitos dos fármacos
Klebsiella/genética
Klebsiella/metabolismo
Mercúrio/farmacologia
Tipagem Molecular
Pseudomonas/efeitos dos fármacos
Pseudomonas/genética
Pseudomonas/metabolismo
RNA Bacteriano/genética
RNA Ribossômico 16S/genética
Serratia marcescens/efeitos dos fármacos
Serratia marcescens/genética
Serratia marcescens/metabolismo
Tolueno/metabolismo
Poluentes Químicos da Água/metabolismo
Purificação da Água
Zinco/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pesticides); 0 (RNA, Bacterial); 0 (RNA, Ribosomal, 16S); 0 (Water Pollutants, Chemical); 3FPU23BG52 (Toluene); 789U1901C5 (Copper); FXS1BY2PGL (Mercury); J41CSQ7QDS (Zinc); JCS58I644W (Chlorpyrifos)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE



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