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[PMID]:29246347
[Au] Autor:Droz N; Enouf V; Bidet P; Mohamed D; Behillil S; Simon AL; Bachy M; Caseris M; Bonacorsi S; Basmaci R
[Ad] Endereço:Pediatric-Emergency Department, Louis-Mourier Hospital, AP-HP, Colombes, France.
[Ti] Título:Temporal Association Between Rhinovirus Activity and Kingella kingae Osteoarticular Infections.
[So] Source:J Pediatr;192:234-239.e2, 2018 Jan.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine whether the seasonal distribution of Kingella kingae osteoarticular infections is similar to that of common respiratory viruses. STUDY DESIGN: Between October 2009 and September 2016, we extracted the results of K kingae-specific real-time polymerase chain reaction analyses performed for bone or joint specimens in patients from 2 pediatric tertiary care centers in Paris. We used data of respiratory virus detection from the Réseau National des Laboratoires network with coordination with the National Influenza Center of France. The Spearman rank correlation was used to assess a correlation between weekly distributions, with P < .05 denoting a significant correlation. RESULTS: During the 7-year study period, 322 children were diagnosed with K kingae osteoarticular infection, and 317 testing episodes were K kingae-negative. We observed high activity for both K kingae osteoarticular infection and human rhinovirus (HRV) during the fall (98 [30.4%] and 2401 [39.1%] cases, respectively) and low activity during summer (59 [18.3%] and 681 [11.1%] cases, respectively). Weekly distributions of K kingae osteoarticular infection and rhinovirus activity were significantly correlated (r = 0.30; P = .03). In contrast, no significant correlation was found between the weekly distribution of K kingae osteoarticular infection and other respiratory viruses (r = -0.17, P = .34 compared with respiratory syncytial virus; r = -0.13, P = .34 compared with influenza virus; and r = -0.22, P = .11 compared with metapneumovirus). CONCLUSION: A significant temporal association was observed between HRV circulation and K kingae osteoarticular infection, strengthening the hypothesis of a role of viral infections in the pathophysiology of K kingae invasive infection.
[Mh] Termos MeSH primário: Artrite Infecciosa/epidemiologia
Kingella kingae
Infecções por Neisseriaceae/epidemiologia
Infecções por Picornaviridae/epidemiologia
Rhinovirus
Estações do Ano
[Mh] Termos MeSH secundário: Artrite Infecciosa/diagnóstico
Artrite Infecciosa/virologia
Pré-Escolar
França/epidemiologia
Seres Humanos
Lactente
Kingella kingae/isolamento & purificação
Infecções por Neisseriaceae/diagnóstico
Infecções por Neisseriaceae/virologia
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


  2 / 212 MEDLINE  
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[PMID]:28874431
[Au] Autor:Gravel J; Ceroni D; Lacroix L; Renaud C; Grimard G; Samara E; Cherkaoui A; Renzi G; Schrenzel J; Manzano S
[Ad] Endereço:Departments of Pediatrics (Gravel), Microbiology (Renaud) and Orthopedics (Grimard), Centre hospitalier universitaire Sainte-Justine, Université de Montréal, Montréal, Que.; Departments of Paediatric Orthopedics (Ceroni, Samara) and Paediatric Emergency Medicine (Lacroix, Manzano), Clinical Microbio
[Ti] Título:Association between oropharyngeal carriage of and osteoarticular infection in young children: a case-control study.
[So] Source:CMAJ;189(35):E1107-E1111, 2017 Sep 05.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: has been increasingly identified in patients with osteoarticular infections. Our main objective was to evaluate the association between carriage of in the oropharynx of preschool children and osteoarticular infections. METHODS: We conducted this prospective case-control study in 2 tertiary care pediatric hospitals (Canada and Switzerland) between 2014 and 2016. Potential cases were children aged 6 to 48 months with a presumptive diagnosis of osteoarticular infection according to the treating emergency physician. Confirmed cases were those with diagnosis of osteomyelitis or septic arthritis proven by positive findings on technetium-labelled bone scan or magnetic resonance imaging or identification of a microorganism in joint aspirate or blood. For each case, we recruited 4 age-matched controls from among children presenting to the same emergency department for trauma. The independent variable was presence of oropharyngeal DNA identified by a specific polymerase chain reaction assay. We determined the association between oropharyngeal carriage of and definitive osteoarticular infection. RESULTS: The parents of 77 children admitted for suspected osteoarticular infection and 286 controls were invited to participate and provided informed consent. We identified in the oropharynx of 46 (71%) of 65 confirmed cases and 17 (6%) of 286 controls; these results yielded an odds ratio of 38.3 (95% confidence interval 18.5-79.1). INTERPRETATION: Detection of oropharyngeal was strongly associated with osteoarticular infection among children presenting with symptoms suggestive of such infection.
[Mh] Termos MeSH primário: Artrite Infecciosa/microbiologia
Portador Sadio/microbiologia
Kingella kingae/isolamento & purificação
Infecções por Neisseriaceae/diagnóstico
Infecções por Neisseriaceae/epidemiologia
Osteomielite/microbiologia
[Mh] Termos MeSH secundário: Artrite Infecciosa/diagnóstico por imagem
Canadá
Estudos de Casos e Controles
Pré-Escolar
Feminino
Hospitais Pediátricos
Seres Humanos
Lactente
Imagem por Ressonância Magnética
Masculino
Razão de Chances
Orofaringe/microbiologia
Osteomielite/diagnóstico por imagem
Reação em Cadeia da Polimerase
Estudos Prospectivos
Suíça
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.170127


  3 / 212 MEDLINE  
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[PMID]:28874430
[Au] Autor:Basmaci R; Bonacorsi S
[Ad] Endereço:Service de Pédiatrie-Urgences (Basmaci), Hôpital Louis-Mourier, Colombes, France; IAME (Basmaci, Bonacorsi), Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Service de Microbiologie (Bonacorsi), Hôpital Robert-Debré, Centre National de Référence associé Escherichia coli, Paris, France romain.basmaci@aphp.fr.
[Ti] Título:: From carriage to infection.
[So] Source:CMAJ;189(35):E1105-E1106, 2017 09 05.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Kingella kingae
[Mh] Termos MeSH secundário: Seres Humanos
Lactente
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.170843


  4 / 212 MEDLINE  
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[PMID]:28874408
[Au] Autor:Kern BK; Porsch EA; St Geme JW
[Ad] Endereço:Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
[Ti] Título:Defining the Mechanical Determinants of Kingella kingae Adherence to Host Cells.
[So] Source:J Bacteriol;199(23), 2017 Dec 01.
[Is] ISSN:1098-5530
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:is an important pathogen in young children and initiates infection by colonizing the posterior pharynx. Adherence to pharyngeal epithelial cells is an important first step in the process of colonization. In the present study, we sought to elucidate the interplay of type IV pili (T4P), a trimeric autotransporter adhesin called Knh, and the polysaccharide capsule in adherence to host cells. Using adherence assays performed under shear stress, we observed that a strain expressing only Knh was capable of higher levels of adherence than a strain expressing only T4P. Using atomic force microscopy and transmission electron microscopy (TEM), we established that the capsule had a mean depth of 700 nm and that Knh was approximately 110 nm long. Using cationic ferritin capsule staining and thin-section transmission electron microscopy, we found that when bacteria expressing retractile T4P were in close contact with host cells, the capsule was absent at the point of contact between the bacterium and the host cell membrane. In a T4P retraction-deficient mutant, the capsule depth remained intact and adherence levels were markedly reduced. These results support the following model: T4P make initial contact with the host cell and mediate low-strength adherence. T4P retract, pulling the organism closer to the host cell and displacing the capsule, allowing Knh to be exposed and mediate high-strength, tight adherence to the host cell surface. This report provides the first description of the mechanical displacement of capsule enabling intimate bacterial adherence to host cells. Adherence to host cells is an important first step in bacterial colonization and pathogenicity. has three surface factors that are involved in adherence: type IV pili (T4P), a trimeric autotransporter adhesin called Knh, and a polysaccharide capsule. Our results suggest that T4P mediate initial contact and low-strength adherence to host cells. T4P retraction draws the bacterium closer to the host cell and causes the displacement of capsule. This displacement exposes Knh and allows Knh to mediate high-strength adherence to the host cell. This work provides new insight into the interplay of T4P, a nonpilus adhesin, and a capsule and their effects on bacterial adherence to host cells.
[Mh] Termos MeSH primário: Aderência Bacteriana/fisiologia
Proteínas de Bactérias/metabolismo
Interações Hospedeiro-Patógeno/fisiologia
Kingella kingae/metabolismo
[Mh] Termos MeSH secundário: Células A549
Adesinas Bacterianas/metabolismo
Linhagem Celular Tumoral
Células Epiteliais/microbiologia
Seres Humanos
Microscopia Eletrônica de Transmissão/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adhesins, Bacterial); 0 (Bacterial Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  5 / 212 MEDLINE  
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[PMID]:28661965
[Au] Autor:Lironi C; Steiger C; Juchler C; Spyropoulou V; Samara E; Ceroni D
[Ad] Endereço:From the *Pediatric Emergency Service, and †Pediatric Orthopedic Service, Child and Adolescent Department, University Hospitals of Geneva, Geneva, Switzerland.
[Ti] Título:Pyogenic Tenosynovitis in Infants: A Case Series.
[So] Source:Pediatr Infect Dis J;36(11):1097-1099, 2017 Nov.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pyogenic tenosynovitis is an uncommon condition in children, and there are few published case reports. We present a series of 11 cases who were treated in the Geneva Children Hospital in the last 10 years. Kingella kingae was the main pathogen, and the characteristics of infection (inflammatory indices, clinical findings and severity) are similar to other osteoarticular K. kingae infections in infants.
[Mh] Termos MeSH primário: Kingella kingae
Infecções por Neisseriaceae
Tenossinovite
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Lactente
Kingella kingae/genética
Kingella kingae/isolamento & purificação
Kingella kingae/patogenicidade
Masculino
Tipagem Molecular
Reação em Cadeia da Polimerase
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001673


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[PMID]:28650419
[Au] Autor:Fernandes Machado SA; Ferreira Freitas JM; Alegrete da Silva NP; Coutinho Costa Moreira JM; Peixoto Pinto RA; de Melo Costa FG
[Ad] Endereço:From the *Orthopaedic Department, Centro Hospitalar de São João, Porto, Portugal; and †Anatomy Institute and ‡Orthopaedic Department, Oporto University, Porto, Portugal.
[Ti] Título:Spondylodiscitis by Kingella Kingae: An Emerging Pathogen in an Older Pediatric Population.
[So] Source:Pediatr Infect Dis J;36(11):1096-1097, 2017 Nov.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In children, greater than 95% of Kingella kingae infections are diagnosed between 6 and 48 months of age. K. kingae has not been systematically investigated, especially in older children. We describe a case of spondylodiscitis by K. kingae in an 8-year-old child.
[Mh] Termos MeSH primário: Discite
Kingella kingae
Infecções por Neisseriaceae
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Criança
Doenças Transmissíveis Emergentes
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001666


  7 / 212 MEDLINE  
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[PMID]:28432046
[Au] Autor:Hourston GJ; Kankam HK; Mitchell PD; Latimer MD
[Ad] Endereço:University of Cambridge Gonville and Caius College, Cambridge, UK.
[Ti] Título:Brodie abscess of the femoral capital epiphysis in a 2-year-old child caused by .
[So] Source:BMJ Case Rep;2017, 2017 Apr 20.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We report the case of a Brodie abscess of the femoral capital epiphysis from which was isolated. This is to the best of our knowledge the first report of a Brodie abscess of the femoral capital epiphysis from which was isolated.
[Mh] Termos MeSH primário: Epífises/microbiologia
Fêmur/microbiologia
Kingella kingae/isolamento & purificação
Infecções por Neisseriaceae/diagnóstico por imagem
[Mh] Termos MeSH secundário: Abscesso/microbiologia
Abscesso/cirurgia
Pré-Escolar
Epífises/diagnóstico por imagem
Fêmur/diagnóstico por imagem
Fêmur/cirurgia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Infecções por Neisseriaceae/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE


  8 / 212 MEDLINE  
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[PMID]:28002358
[Au] Autor:El Houmami N; Cointat V; Mirand A; Fouilloux V; Bzdrenga J; Bakour S; Minodier P; Dubois MA; Anave-Frapech F; Charrel R; Raoult D; Fournier PE
[Ad] Endereço:From the *URMITE " Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes", UM63, Inserm 1095, CNRS 7278, IRD 198, Institut Hospitalo-Universitaire Méditerranée-Infection, Aix-Marseille University, Marseille, France; †Childcare Centers, Nice, France; ‡Laboratoire de Virologie, Centre National de Référence des Enterovirus et Parechovirus-laboratoire associé, CHU de Clermont-Ferrand, Clermont-Ferrand, France; §Department of Pediatric Cardiac Surgery, La Timone Children's Hospital, Aix-Marseille University, Marseille, France; ¶Department of Pediatric Emergency Medicine, North Hospital, Marseille, France; ‖Department of Pediatrics, Foundation Lenval Children's Hospital, Nice, France; **Laboratory of Foundation Lenval Children's Hospital, Nice, France; and ††IRD French Institute of Research and Development, EHESP French School of Public Health, EPV UMR_D 190 "Emergence des Pathologies Virales," Institut Hospitalo-Universitaire Méditerranée-Infection, Aix Marseille Université, Marseille, France.
[Ti] Título:An Outbreak of Kingella Kingae Infections Complicating a Severe Hand, Foot, And Mouth Disease Outbreak in Nice, France, 2016.
[So] Source:Pediatr Infect Dis J;36(5):530-532, 2017 May.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report the investigation methods for the diagnosis of an epidemic and culture-negative Kingella kingae endocarditis complicating a severe outbreak of hand, foot and mouth disease in a childcare center. The diagnosis was confirmed by polymerase chain reaction testing performed from cardiac tissue. Our findings argue for the systematic investigation of K. kingae outbreaks by using molecular tools in such context.
[Mh] Termos MeSH primário: Surtos de Doenças
Endocardite Bacteriana/diagnóstico
Doença de Mão, Pé e Boca/complicações
Doença de Mão, Pé e Boca/epidemiologia
Kingella kingae/isolamento & purificação
Infecções por Neisseriaceae/diagnóstico
[Mh] Termos MeSH secundário: Endocardite Bacteriana/complicações
Endocardite Bacteriana/microbiologia
Endocardite Bacteriana/patologia
Feminino
França/epidemiologia
Seres Humanos
Lactente
Kingella kingae/genética
Masculino
Técnicas de Diagnóstico Molecular
Infecções por Neisseriaceae/complicações
Infecções por Neisseriaceae/microbiologia
Infecções por Neisseriaceae/patologia
Reação em Cadeia da Polimerase
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170419
[Lr] Data última revisão:
170419
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001487


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[PMID]:27956728
[Au] Autor:Dabaja-Younis H; Kassis I; Ilivitzki A; Steinberg R; Shachor-Meyouhas Y
[Ad] Endereço:From the *Pediatric Infectious Diseases Unit, Ruth Rappaport Children's Hospital, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Haifa, Israel; †Technion-Israel Institute of Technology, and Ruth Rappaport Children's Hospital Rambam Health Care Campus, Haifa, Israel; ‡Pediatric Imaging Unit, Ruth Rappaport Children's Hospital, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Haifa, Israel; and §Department of Pediatric Surgery, Ruth Rappaport Children's Hospital, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Haifa, Israel.
[Ti] Título:Kingella Kingae Chest Mass Mimicking a Tumor in an 11-Month-Old Baby.
[So] Source:Pediatr Infect Dis J;36(1):110-113, 2017 Jan.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Kingella kingae has been recognized as a common etiology of pediatric osteoarticular infections, especially among children younger than 5 years of age. In recent years, there have been reported cases of unusual manifestations. We report a rare case of a chest mass mimicking a tumor in an 11-month-old baby.
[Mh] Termos MeSH primário: Kingella kingae
Infecções por Neisseriaceae
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Diagnóstico Diferencial
Seres Humanos
Lactente
Masculino
Infecções por Neisseriaceae/diagnóstico
Infecções por Neisseriaceae/tratamento farmacológico
Infecções por Neisseriaceae/patologia
Neoplasias
Parede Torácica/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE


  10 / 212 MEDLINE  
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[PMID]:27669685
[Au] Autor:Khatami A; Rivers BR; Outhred AC; Kesson AM
[Ad] Endereço:Department of Microbiology and Infectious Diseases, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
[Ti] Título:Low prevalence of Kingella kingae carriage in children aged 6-48 months in Sydney, Australia.
[So] Source:J Paediatr Child Health;53(2):170-172, 2017 Feb.
[Is] ISSN:1440-1754
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:AIM: A prospective observational study was conducted to estimate the prevalence of oropharyngeal carriage of Kingella kingae in healthy Australian pre-school children. METHODS: Screening for carriage of K. kingae as well as Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus aureus, Haemophilus influenzae, and K. kingae was undertaken using a single bacterial throat swab taken from well children aged 6 months to 4 years. Standard laboratory procedures were used for culture and identification of organisms. RESULTS: One hundred children were enrolled between October and December 2014 at the Children's Hospital at Westmead. Median age was 24.0 months (range 6.1-48.8 months); 52 children were male and 36 attended day-care facilities. Forty-one children had siblings aged less than 5 years and 67 children had siblings of any age. K. kingae oropharyngeal carriage was not detected in any of the children. Rates of carriage of other organisms were: 30% S. aureus, 21% H. influenzae, 2% S. pneumoniae and 2% S. pyogenes. Thirty-eight children were colonised with Kingella denitrificans. CONCLUSIONS: Our results suggest that prevalence of K. kingae carriage in pre-school children in Sydney is very low and support local and national guidelines that recommend flucloxacillin as empiric first-line therapy for children with osteoarticular infections. Studies conducted over the winter months and in other Australian centres could help answer outstanding questions regarding differences in carriage rates of K. kingae in children.
[Mh] Termos MeSH primário: Kingella kingae/isolamento & purificação
Infecções por Neisseriaceae/epidemiologia
[Mh] Termos MeSH secundário: Pré-Escolar
Hospitais Pediátricos
Seres Humanos
Lactente
Programas de Rastreamento/métodos
New South Wales/epidemiologia
Prevalência
Estudos Prospectivos
Saúde da População Urbana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160928
[St] Status:MEDLINE
[do] DOI:10.1111/jpc.13337



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