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[PMID]:28942279
[Au] Autor:Wen X; Wang Y; Zou Y; Ma B; Wu Y
[Ad] Endereço:College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
[Ti] Título:No evidential correlation between veterinary antibiotic degradation ability and resistance genes in microorganisms during the biodegradation of doxycycline.
[So] Source:Ecotoxicol Environ Saf;147:759-766, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Biodegradation of antibiotic residues in the environment by microorganisms may lead to the generation of antibiotic resistance genes (ARGs), which are of great concern to human health. The aim of this study was to determine whether there is a relationship between the ability to degrade antibiotic doxycycline (DOX) and the development of resistance genes in microorganisms. We isolated and identified ten bacterial strains from a vegetable field that had received long-term manure application as fertilizer and were capable of surviving in a series of DOX concentrations (25, 50, 80, and 100mg/L). Our results showed no evidential correlation between DOX degradation ability and the development of resistance genes among the isolated microorganisms that had high DOX degradation capability (P > 0.05). This was based on the fact that Escherichia sp. and Candida sp. were the most efficient bacterial strains to degrade DOX (92.52% and 91.63%, respectively), but their tetracycline resistance genes showed a relatively low risk of antibiotic resistance in a 7-day experiment. Moreover, the tetM of the ribosomal protection protein genes carried by these two preponderant bacteria was five-fold higher than that carried by other isolates (P < 0.05). Pearson correlations between the C /C of DOX and tet resistance genes of three isolates, except for Escherichia sp. and Candida sp., showed remarkable negative correlations (P < 0.05), mainly because tetG markedly increased during the DOX degradation process. Our results concluded that the biodegradation of antibiotic residues may not necessarily lead to the development of ARGs in the environment. In addition, the two bacteria that we isolated, namely, Escherichia sp. and Candida sp., are potential candidates for the engineering of environmentally friendly bacteria.
[Mh] Termos MeSH primário: Doxiciclina/toxicidade
Resistência Microbiana a Medicamentos/efeitos dos fármacos
Microbiologia do Solo/normas
Poluentes do Solo/toxicidade
Drogas Veterinárias/toxicidade
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Candida/efeitos dos fármacos
Candida/genética
China
Relação Dose-Resposta a Droga
Resistência Microbiana a Medicamentos/genética
Escherichia/efeitos dos fármacos
Escherichia/genética
Fertilizantes
Genes Bacterianos
Esterco/microbiologia
Resistência a Tetraciclina/efeitos dos fármacos
Resistência a Tetraciclina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fertilizers); 0 (Manure); 0 (Soil Pollutants); 0 (Veterinary Drugs); N12000U13O (Doxycycline)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


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[PMID]:28600898
[Au] Autor:Tasnádi G; Zechner M; Hall M; Baldenius K; Ditrich K; Faber K
[Ad] Endereço:Austrian Centre of Industrial Biotechnology, c/o.
[Ti] Título:Investigation of acid phosphatase variants for the synthesis of phosphate monoesters.
[So] Source:Biotechnol Bioeng;114(10):2187-2195, 2017 Oct.
[Is] ISSN:1097-0290
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The major drawback of using phosphatases for transphosphorylation reactions lies in product depletion caused by the natural hydrolytic activity of the enzymes. Variants of PhoC-Mm from Morganella morganii and NSAP-Eb from Escherichia blattae were studied for their ability to maintain a high product level in the transphosphorylation of various primary alcohols. A single amino acid exchange delivered phosphatase variant PhoC-Mm G92D, which was able to catalyze the phosphorylation of primary alcohols without any major hydrolysis of the formed phosphate esters. The mutation mostly improved the affinity of the enzyme for alcohols, while rate constants of transphosphorylation and hydrolysis were decreased, overall resulting in a superior catalytic efficiency in transphosphorylation compared to hydrolysis. The presence of residual substrate alcohol at a given concentration was crucial to suppress phosphate ester hydrolysis. The present work extends the synthetic applicability of phosphatase variants beyond the previously reported nucleosides and allows preparative-scale production of various primary phosphate esters (yields up to 42%) with high enzyme productivity (TONs up to ∼66,000). Biotechnol. Bioeng. 2017;114: 2187-2195. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Fosfatase Ácida/química
Álcoois/química
Escherichia/enzimologia
Ésteres/síntese química
Morganella morganii/enzimologia
Fosfatos/síntese química
[Mh] Termos MeSH secundário: Fosfatase Ácida/genética
Ativação Enzimática
Mutagênese Sítio-Dirigida
Fosforilação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alcohols); 0 (Esters); 0 (Phosphates); EC 3.1.3.2 (Acid Phosphatase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE
[do] DOI:10.1002/bit.26352


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[PMID]:28597684
[Au] Autor:Chowdhury FM; Rahman MZ; Sarkar MMH; Rabbi F; Khan SI; Ahsan CR; Birkeland NK
[Ad] Endereço:1 Department of Microbiology, University of Dhaka , Dhaka, Bangladesh.
[Ti] Título:Protection against shigellosis caused by Shigella dysenteriae serotype 4 in guinea pigs using Escherichia albertii DM104 as a live vaccine candidate strain.
[So] Source:Acta Microbiol Immunol Hung;64(2):151-164, 2017 Jun 01.
[Is] ISSN:1217-8950
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:Recently, we reported the induction of protective immunity by environmental Escherichia albertii strain DM104 against Shigella dysenteriae in guinea pig model. In this study, we assessed three different immunization routes, such as intranasal, oral, and intrarectal routes, and revealed differences in immune responses by measuring both the serum IgG and mucosal IgA antibody titers. Protective efficacy of different routes of immunization was also determined by challenging immunized guinea pigs against live S. dysenteriae. It was found that intranasal immunization showed promising results in terms of antibody response and protective efficacy. All these results reconfirm our previous findings and additionally point out that the intranasal immunization of the environmental E. albertii strain DM104 in guinea pig model can be a better live vaccine candidate against shigellosis.
[Mh] Termos MeSH primário: Vacinas Bacterianas/imunologia
Disenteria Bacilar/prevenção & controle
Escherichia/imunologia
Shigella dysenteriae/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/imunologia
Vacinas Bacterianas/administração & dosagem
Vacinas Bacterianas/genética
Proteção Cruzada
Disenteria Bacilar/imunologia
Disenteria Bacilar/microbiologia
Escherichia/genética
Cobaias
Seres Humanos
Masculino
Sorogrupo
Shigella dysenteriae/genética
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Bacterial Vaccines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1556/030.64.2017.015


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[PMID]:28178312
[Au] Autor:Yamamoto D; Hernandes RT; Liberatore AM; Abe CM; Souza RB; Romão FT; Sperandio V; Koh IH; Gomes TA
[Ad] Endereço:Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP-EPM), São Paulo, Brazil.
[Ti] Título:Escherichia albertii, a novel human enteropathogen, colonizes rat enterocytes and translocates to extra-intestinal sites.
[So] Source:PLoS One;12(2):e0171385, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Diarrhea is the second leading cause of death of children up to five years old in the developing countries. Among the etiological diarrheal agents are atypical enteropathogenic Escherichia coli (aEPEC), one of the diarrheagenic E. coli pathotypes that affects children and adults, even in developed countries. Currently, genotypic and biochemical approaches have helped to demonstrate that some strains classified as aEPEC are actually E. albertii, a recently recognized human enteropathogen. Studies on particular strains are necessary to explore their virulence potential in order to further understand the underlying mechanisms of E. albertii infections. Here we demonstrated for the first time that infection of fragments of rat intestinal mucosa is a useful tool to study the initial steps of E. albertii colonization. We also observed that an E. albertii strain can translocate from the intestinal lumen to Mesenteric Lymph Nodes and liver in a rat model. Based on our finding of bacterial translocation, we investigated how E. albertii might cross the intestinal epithelium by performing infections of M-like cells in vitro to identify the potential in vivo translocation route. Altogether, our approaches allowed us to draft a general E. albertii infection route from the colonization till the bacterial spreading in vivo.
[Mh] Termos MeSH primário: Enterócitos/microbiologia
Escherichia/fisiologia
Mucosa Intestinal/microbiologia
[Mh] Termos MeSH secundário: Adesinas Bacterianas/genética
Adesinas Bacterianas/metabolismo
Animais
Linhagem Celular
Células Cultivadas
Infecções por Enterobacteriaceae/microbiologia
Enterócitos/ultraestrutura
Escherichia/ultraestrutura
Feminino
Seres Humanos
Mutação
Ratos
Sistemas de Secreção Tipo III/genética
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adhesins, Bacterial); 0 (Type III Secretion Systems)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171385


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[PMID]:27918986
[Au] Autor:Kumar R; Oves M; Almeelbi T; Al-Makishah NH; Barakat MA
[Ad] Endereço:Department of Environmental Sciences, Faculty of Meteorology, Environment and Arid Land Agriculture, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
[Ti] Título:Hybrid chitosan/polyaniline-polypyrrole biomaterial for enhanced adsorption and antimicrobial activity.
[So] Source:J Colloid Interface Sci;490:488-496, 2017 Mar 15.
[Is] ISSN:1095-7103
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this work, chitosan (CS) functionalized polyaniline-polypyrrole (Pani-Ppy) copolymer (CS/Pani-Ppy) was synthesized applying a facile one pot method for the enhanced adsorption of Zn(II) and antimicrobial activity for E. coli and E. agglomerans. The synthesized materials were characterized using scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform inferred spectroscopy and X-ray photoelectron spectroscopy. The adsorption of the Zn(II) on the synthesized materials was highly dependent on the pH of the solution, the initial metal ion concentration, and temperature. The adsorption of Zn(II) on the studied materials was as follows: CS/Pani-Ppy>Pani-Ppy>Ppy>Pani>CS. The results reveal that adsorption of Zn(II) follows the Langmuir adsorption isotherm, and that chemisorption occurs through pendant and bridging interactions, with active adsorbent sites. Thermodynamic results show the adsorption is spontaneous and exothermic in nature. The synthesized materials show excellent antimicrobial activity against E. coli and E. agglomerans bacterial organisms, and an approximately 100% decline in the viability of both strains was observed with CS/Pani-Ppy and Pani-Ppy. The order of antimicrobial activity for the synthesized materials was as follows: CS/Ppy-Pani>Ppy-Pani>Ppy>Pani>CS. The results show that the greater activity of CS/Ppy-Pani resulted from the electrostatic interaction between positively charged amine groups and negatively charged bacteria.
[Mh] Termos MeSH primário: Compostos de Anilina/química
Antibacterianos/química
Materiais Biocompatíveis/química
Quitosana/análogos & derivados
Polímeros/química
Pirróis/química
Zinco/isolamento & purificação
[Mh] Termos MeSH secundário: Adsorção
Compostos de Anilina/farmacologia
Antibacterianos/farmacologia
Materiais Biocompatíveis/farmacologia
Cátions Bivalentes/isolamento & purificação
Quitosana/farmacologia
Infecções por Enterobacteriaceae/prevenção & controle
Escherichia/efeitos dos fármacos
Escherichia/isolamento & purificação
Seres Humanos
Polímeros/farmacologia
Pirróis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aniline Compounds); 0 (Anti-Bacterial Agents); 0 (Biocompatible Materials); 0 (Cations, Divalent); 0 (Polymers); 0 (Pyrroles); 0 (polyaniline); 30604-81-0 (polypyrrole); 9012-76-4 (Chitosan); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27795309
[Au] Autor:Projahn M; Daehre K; Roesler U; Friese A
[Ad] Endereço:Institute for Animal Hygiene and Environmental Health, Freie Universität Berlin, Berlin, Germany michaela.projahn@fu-berlin.de.
[Ti] Título:Extended-Spectrum-Beta-Lactamase- and Plasmid-Encoded Cephamycinase-Producing Enterobacteria in the Broiler Hatchery as a Potential Mode of Pseudo-Vertical Transmission.
[So] Source:Appl Environ Microbiol;83(1), 2017 Jan 01.
[Is] ISSN:1098-5336
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antimicrobial resistance through extended-spectrum beta-lactamases (ESBLs) and transferable (plasmid-encoded) cephamycinases (pAmpCs) represents an increasing problem in human and veterinary medicine. The presence of ESBL-/pAmpC-producing commensal enterobacteria in farm animals, such as broiler chickens, is considered one possible source of food contamination and could therefore also be relevant for human colonization. Studies on transmission routes along the broiler production chain showed that 1-day-old hatchlings are already affected. In this study, ESBL-/pAmpC-positive broiler parent flocks and their corresponding eggs, as well as various environmental and air samples from the hatchery, were analyzed. The eggs were investigated concerning ESBL-/pAmpC-producing enterobacteria on the outer eggshell surface (before/after disinfection), the inner eggshell surface, and the egg content. Isolates were analyzed concerning their species, their phylogroup in the case of Escherichia coli strains, the respective resistance genes, and the phenotypical antibiotic resistance. Of the tested eggs, 0.9% (n = 560) were contaminated on their outer shell surface. Further analyses using pulsed-field gel electrophoresis showed a relationship of these strains to those isolated from the corresponding parent flocks, which demonstrates a pseudo-vertical transfer of ESBL-/pAmpC-producing enterobacteria into the hatchery. Resistant enterobacteria were also found in environmental samples from the hatchery, such as dust or surfaces which could pose as a possible contamination source for the hatchlings. All 1-day-old chicks tested negative directly after hatching. The results show a possible entry of ESBL-/pAmpC-producing enterobacteria from the parent flocks into the hatchery; however, the impact of the hatchery on colonization of the hatchlings seems to be low. IMPORTANCE: ESBL-/pAmpC-producing enterobacteria occur frequently in broiler-fattening farms. Recent studies investigated the prevalence and possible transmission route of these bacteria in the broiler production chain. It seemed very likely that the hatcheries play an important role in transmission and/or contamination events. There are only few data on transmission investigations from a grandparent or parent flock to their offspring. However, reliable data on direct or indirect vertical transmission events in the hatchery are not available. Therefore, we conducted our study and intensively investigated the broiler hatching eggs from ESBL-/pAmpC-positive broiler parent flocks as well as the hatchlings and the environment of the hatchery.
[Mh] Termos MeSH primário: Cefamicinas/metabolismo
Infecções por Enterobacteriaceae/veterinária
Escherichia coli/genética
Escherichia/genética
Transmissão Vertical de Doença Infecciosa/veterinária
Doenças das Aves Domésticas/transmissão
beta-Lactamases/genética
[Mh] Termos MeSH secundário: Animais
Animais Domésticos
Galinhas/microbiologia
Farmacorresistência Bacteriana Múltipla/genética
Ovos/microbiologia
Infecções por Enterobacteriaceae/microbiologia
Infecções por Enterobacteriaceae/transmissão
Escherichia/efeitos dos fármacos
Escherichia/enzimologia
Escherichia/isolamento & purificação
Escherichia coli/efeitos dos fármacos
Escherichia coli/enzimologia
Escherichia coli/isolamento & purificação
Infecções por Escherichia coli/microbiologia
Infecções por Escherichia coli/transmissão
Infecções por Escherichia coli/veterinária
Fazendas
Seres Humanos
Plasmídeos
Doenças das Aves Domésticas/microbiologia
beta-Lactamases/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cephamycins); EC 3.5.2.6 (beta-Lactamases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE


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[PMID]:27785540
[Au] Autor:Wang S; Zhang MN; Bai NL; Ding HT; Zhu XF; Zhao YH
[Ad] Endereço:College of Life Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, People's Republic of China.
[Ti] Título:Construction, properties, and application of the pCB5 plasmid, a novel conjugative shuttle vector with a Cupriavidus basilensis origin of replication.
[So] Source:Appl Microbiol Biotechnol;101(3):1217-1226, 2017 Feb.
[Is] ISSN:1432-0614
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Cupriavidus basilensis is a species with diverse metabolic capabilities, including degradation of xenobiotics and heavy metal resistance. Although the genomes of several strains of this species have been sequenced, no plasmid has yet been constructed for genetic engineering in this species. In this study, we identified a novel plasmid, designated pWS, from C. basilensis WS with a copy number of 1-3 per cell and a length of 2150 bp. pWS contained three protein-coding genes, among which only rep was required for plasmid replication. Rep showed no homology with known plasmid replication initiators. Unlike most plasmids, pWS did not have a cis-acting replication origin outside the region of rep. The minimal replicon of pWS was stable in C. basilensis WS without selection. A conjugative C. basilensis/Escherichia coli shuttle vector, pCB5, was constructed using the minimal replicon of pWS. Interestingly, the copy number of pCB5 was flexible and could be manipulated. Enhancing the expression level of Rep in pCB5 by either doubling the promoter or coding region of rep resulted in doubling of the plasmid copy number. Moreover, replacing the native promoter of rep with the lac promoter increased the copy number by over fivefold. Finally, using two different ß-galactosidase reporting systems constructed with pCB5, we successfully demonstrated the different regulatory patterns of bph and dmp operons during diphenyl ether (DE) degradation in C. basilensis WS. Thus, this shuttle vector provided an efficient tool for DNA cloning and metabolic engineering in C. basilensis.
[Mh] Termos MeSH primário: Cupriavidus/genética
Vetores Genéticos
Plasmídeos/genética
Origem de Replicação
[Mh] Termos MeSH secundário: Sequência de Bases
Clonagem Molecular
Escherichia/genética
Dosagem de Genes
Engenharia Genética
Engenharia Metabólica
Óperon
Éteres Fenílicos/metabolismo
Plasmídeos/isolamento & purificação
Plasmídeos/metabolismo
Regiões Promotoras Genéticas
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenyl Ethers); 3O695R5M1U (phenyl ether)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.1007/s00253-016-7936-3


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[PMID]:28221930
[Au] Autor:Jones-Ibarra AM; Wall KR; Vuia-Riser J; Kerth CR; Castillo A; Taylor TM
[Ad] Endereço:Department of Nutrition and Food Science, Texas A&M University, College Station, Texas 77843, USA.
[Ti] Título:Escherichia albertii Inactivation following l-Lactic Acid Exposure or Cooking in Ground Beef.
[So] Source:J Food Prot;79(9):1475-1481, 2016 Sep.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Escherichia albertii is an emerging foodborne pathogen recovered from young children and adults exhibiting symptoms of gastroenteritis via pathogenesis factors including attaching and effacing lesions, cytolethal distending toxin, and Shiga toxin variants. Study objectives were to determine E. albertii survival following (i) exposure to lactic acid as a function of solution pH and incubation period and (ii) cooking ground beef patties to different endpoint temperatures. E. albertii was incubated in phosphate buffer containing 3.0% l-lactic acid adjusted to pH 3.0, 4.0, 5.0, or 7.0; survivors were determined every 30 min for 150 min. Ground beef patties (80% lean) were cooked to temperature endpoints simulating undercooking (62°C), the minimum temperature for safe cooking (71.1°C), and cooking to well done (76°C). Maximal pathogen reduction was observed after a 30-min exposure to pH 3.0 l-lactic acid. Reductions of 3.9, 4.4, and 4.9 log CFU/g were obtained following cooking ground beef patties to 62, 71.1, and 76°C, respectively, but the reductions did not differ as a function of the endpoint cooking temperature (P ≥ 0.05). E. albertii may be controlled on beef through the proper application of antimicrobial interventions and cooking.
[Mh] Termos MeSH primário: Ácido Láctico
Produtos da Carne
[Mh] Termos MeSH secundário: Animais
Bovinos
Contagem de Colônia Microbiana
Culinária
Escherichia
Escherichia coli O157
Manipulação de Alimentos
Microbiologia de Alimentos
Temperatura Alta
Seres Humanos
Carne
Carne Vermelha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
33X04XA5AT (Lactic Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-15-487


  9 / 742 MEDLINE  
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[PMID]:28206920
[Au] Autor:Hagler D; Prabhakaran K; Lombardo G; Marini CP
[Ad] Endereço:Division of Trauma, Acute Care and Critical Care Surgery, Department of Surgery, Westchester Medical Center, Valhalla, New York, USA.
[Ti] Título:Splenic Abscess Requiring Early Splenectomy Following Angioembolization for Blunt Splenic Injury in an Immunocompromised Host: Implications for Management.
[So] Source:Am Surg;82(11):310-312, 2016 Nov 01.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Abscesso/cirurgia
Abscesso/terapia
Baço/lesões
Esplenectomia
Esplenopatias/cirurgia
Ferimentos não Penetrantes/complicações
[Mh] Termos MeSH secundário: Abscesso/microbiologia
Idoso
Diabetes Mellitus Tipo 2
Embolização Terapêutica/métodos
Infecções por Enterobacteriaceae/microbiologia
Escherichia
Infecções por HIV
Seres Humanos
Hospedeiro Imunocomprometido
Masculino
Baço/irrigação sanguínea
Esplenopatias/microbiologia
Esplenopatias/terapia
Ferimentos não Penetrantes/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE


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[PMID]:27717398
[Au] Autor:Davis MY; Zhang H; Brannan LE; Carman RJ; Boone JH
[Ad] Endereço:TechLab, Inc., 2001 Kraft Drive, Blacksburg, VA, 24060, USA. mdavis@techlab.com.
[Ti] Título:Rapid change of fecal microbiome and disappearance of Clostridium difficile in a colonized infant after transition from breast milk to cow milk.
[So] Source:Microbiome;4(1):53, 2016 10 07.
[Is] ISSN:2049-2618
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clostridium difficile is the most common known cause of antibiotic-associated diarrhea. Upon the disturbance of gut microbiota by antibiotics, C. difficile establishes growth and releases toxins A and B, which cause tissue damage in the host. The symptoms of C. difficile infection disease range from mild diarrhea to pseudomembranous colitis and toxic megacolon. Interestingly, 10-50 % of infants are asymptomatic carriers of C. difficile. This longitudinal study of the C. difficile colonization in an infant revealed the dynamics of C. difficile presence in gut microbiota. METHODS: Fifty fecal samples, collected weekly between 5.5 and 17 months of age from a female infant who was an asymptomatic carrier of C. difficile, were analyzed by 16S rRNA gene sequencing. RESULTS: Colonization switching between toxigenic and non-toxigenic C. difficile strains as well as more than 100,000-fold fluctuations of C. difficile counts were observed. C. difficile toxins were detected during the testing period in some infant stool samples, but the infant never had diarrhea. Although fecal microbiota was stable during breast feeding, a dramatic and permanent change of microbiota composition was observed within 5 days of the transition from human milk to cow milk. A rapid decline and eventual disappearance of C. difficile coincided with weaning at 12.5 months. An increase in the relative abundance of Bacteroides spp., Blautia spp., Parabacteroides spp., Coprococcus spp., Ruminococcus spp., and Oscillospira spp. and a decrease of Bifidobacterium spp., Lactobacillus spp., Escherichia spp., and Clostridium spp. were observed during weaning. The change in microbiome composition was accompanied by a gradual increase of fecal pH from 5.5 to 7. CONCLUSIONS: The bacterial groups that are less abundant in early infancy, and that increase in relative abundance after weaning, likely are responsible for the expulsion of C. difficile.
[Mh] Termos MeSH primário: Infecções Assintomáticas
Carga Bacteriana
Aleitamento Materno
Infecções por Clostridium/microbiologia
Clostridium difficile/crescimento & desenvolvimento
Microbioma Gastrointestinal/fisiologia
Leite Humano
Desmame
[Mh] Termos MeSH secundário: Proteínas de Bactérias/metabolismo
Toxinas Bacterianas/metabolismo
Bacteroides/crescimento & desenvolvimento
Bifidobacterium/crescimento & desenvolvimento
Clostridium/crescimento & desenvolvimento
Enterotoxinas/metabolismo
Escherichia/crescimento & desenvolvimento
Fezes/microbiologia
Feminino
Seres Humanos
Lactente
Lactobacillus/crescimento & desenvolvimento
RNA Ribossômico 16S/genética
Ruminococcus/crescimento & desenvolvimento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Bacterial Toxins); 0 (Enterotoxins); 0 (RNA, Ribosomal, 16S); 0 (tcdA protein, Clostridium difficile); 0 (toxB protein, Clostridium difficile)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE



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