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[PMID]:29297845
[Au] Autor:Dai H; Wang Y; Fang Y; Xiao T; Huang Z; Kan B; Wang D
[Ad] Endereço:1​State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, 102206, PR China.
[Ti] Título:Proteus columbae sp. nov., isolated from a pigeon in Ma'anshan, China.
[So] Source:Int J Syst Evol Microbiol;68(2):552-557, 2018 Feb.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A Gram-negative, facultatively anaerobic bacillus, strain 08MAS2615 , was isolated from the flesh of a pigeon specimen collected in Ma'anshan, Anhui province, China. Phylogenetic analysis of 16S rRNA gene sequences confirmed that strain 08MAS2615 belonged to the genus Proteus, and formed an independent branch which was clearly separated from the other six known species of Proteus. Strain 08MAS2615 was more closely related to Proteus vulgaris ATCC 29905 and Proteus penneri NCTC 12737 than other Proteus species. Similar independent phylogenetic results were obtained using rpoB gene sequence analysis, whereas strain 08MAS2615 clustered near the species of Proteus cibarius JS9 and Proteus terrae N5/687 . Furthermore, the genome-wide core-single nucleotide polymorphism-based phylogenetic tree confirmed that strain 08MAS2615 formed a monophyletic and robust clade. Based on whole-genome sequences, the range of in silico DNA-DNA hybridization and average nucleotide identity between strain 08MAS2615 and the six Proteus species were 25.5-48.8 % and 82.8-92.9 %, respectively, less than the proposed cutoff level for species delineation, i.e. 70 and 95 %. In addition, the major cellular fatty acid profile of strain 08MAS2615 was C14 : 0 (12.4 %), C16 : 0 (23.8 %), C17 : 0cyclo (14.4 %), summed feature 2 (C16 : 1iso I/C14 : 0 3-OH) (11.0 %), summed feature 3 (C16 : 1ω7c/16 : 1ω6c) (18.5 %) and summed feature 8 (C18 : 1ω6c) (18.6 %). On the basis of these results, strain 08MAS2615 represents a novel species of the genus Proteus, for which the name Proteuscolumbae sp. nov. is proposed with strain 08MAS2615 (=DSM 104686 =CGMCC 1.15982 ) designated as the species type strain.
[Mh] Termos MeSH primário: Columbidae/microbiologia
Filogenia
Proteus/classificação
[Mh] Termos MeSH secundário: Animais
Técnicas de Tipagem Bacteriana
Composição de Bases
China
DNA Bacteriano/genética
Ácidos Graxos/química
Genes Bacterianos
Hibridização de Ácido Nucleico
Proteus/genética
Proteus/isolamento & purificação
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002541


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[PMID]:28845933
[Au] Autor:Kogan MI; Naboka YL; Bedzhanyan SK; Mitusova EV; Gudima IA; Morgun PP; Vasileva LI
[Ad] Endereço:RostSMU of Minzdrav of Russia, Rostov on Don, Russia.
[Ti] Título:[Is bacteriological testing of bladder urine informative in acute obstructive pyelo- nephritis?]
[So] Source:Urologiia;(3):10-15, 2017 Jul.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The problem of the etiology and pathogenesis of acute obstructive pyelonephritis (OOP) remains one of the challenging issues of modern urology. Etiological agents of pyelonephritis can be both gram-negative and gram-positive opportunistic bacteria mostly belonging to the normal flora in humans. The generally accepted diagnostic work-up involves a bacteriological testing of not pelvic urine, but of bladder urine collected by a transurethral catheter or midstream specimens of urine collected from the patients. The aim of our study was to compare the microbiota of bladder and pelvic urine in patients with OOP. MATERIALS AND METHODS: The study comprised 72 sequentially selected patients (12 men and 60 women) with OOP associated with ureteral stones. Mean age of patients was 53.7+/-0.5 years. All patients underwent bacteriological examination of the bladder urine collected by a transurethral catheter and pelvic urine obtained after relieving stone-related ureteral obstruction. Urinary diversion was performed using j-j stent and PCN in 64 and 8 patients, respectively. Preoperative prophylactic antibiotics were administered routinely. Bacteriological testing of urine was carried out using an extended set (9-10) of culture media. Empirical antibiotic therapy was initiated only after the restoration of urine outflow from the kidney and continued for 5-6 days until the availability of bacteriological testing results. RESULTS: Levels of bacteriuria with Enterobacteria, gram-positive pathogens and NAB in two urine samples did not differ significantly (p>0.05). There was a wide range of bacteriuria from 101 to 106 CFU/ml of most microorganisms except @Proteus spp., S. aureus. In bladder urine, the rates of bacteriuria of more or equal 104 CFU/ml for E. coli, Klebsiella spp. and Proteus spp. were 90.9%, 72.7% and 100.0%, respectively. For the remaining microorganisms, predominant bacteriuria was less or equal 103 CFU/ml. In pelvic urine, the rates of bacteriuria of more or equal 104 CFU/ml for E. coli, Klebsiella spp. and Proteus spp. was 71.8%, 40.0% and 66.7%, respectively. Other uropathogens in the pelvic urine mainly had a bacterial count of less or equal 103 CFU/ml. Only the concentration of Corynebacterium spp. in the pelvic urine significantly (p=0.023) differed from that of the bladder urine. There were no significant differences between microbiota of bladder and pelvic urine depending on duration of OOP except higher rates of Corynebacterium spp. in the bladder urine.
[Mh] Termos MeSH primário: Pielonefrite/urina
Infecções Urinárias/urina
Urina/microbiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Antibacterianos/administração & dosagem
Bacteriúria/prevenção & controle
Bacteriúria/urina
Corynebacterium/isolamento & purificação
Escherichia coli/isolamento & purificação
Feminino
Seres Humanos
Klebsiella/isolamento & purificação
Masculino
Meia-Idade
Proteus/isolamento & purificação
Pielonefrite/prevenção & controle
Infecções Urinárias/prevenção & controle
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


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[PMID]:28817637
[Au] Autor:Yu X; Torzewska A; Zhang X; Yin Z; Drzewiecka D; Cao H; Liu B; Knirel YA; Rozalski A; Wang L
[Ad] Endereço:Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, TEDA College, Nankai University, Tianjin, P. R. China.
[Ti] Título:Genetic diversity of the O antigens of Proteus species and the development of a suspension array for molecular serotyping.
[So] Source:PLoS One;12(8):e0183267, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Proteus species are well-known opportunistic pathogens frequently associated with skin wound and urinary tract infections in humans and animals. O antigen diversity is important for bacteria to adapt to different hosts and environments, and has been used to identify serotypes of Proteus isolates. At present, 80 Proteus O-serotypes have been reported. Although the O antigen structures of most Proteus serotypes have been identified, the genetic features of these O antigens have not been well characterized. The O antigen gene clusters of Proteus species are located between the cpxA and secB genes. In this study, we identified 55 O antigen gene clusters of different Proteus serotypes. All clusters contain both the wzx and wzy genes and exhibit a high degree of heterogeneity. Potential functions of O antigen-related genes were proposed based on their similarity to genes in available databases. The O antigen gene clusters and structures were compared, and a number of glycosyltransferases were assigned to glycosidic linkages. In addition, an O serotype-specific suspension array was developed for detecting 31 Proteus serotypes frequently isolated from clinical specimens. To our knowledge, this is the first comprehensive report to describe the genetic features of Proteus O antigens and to develop a molecular technique to identify different Proteus serotypes.
[Mh] Termos MeSH primário: Genes Bacterianos
Antígenos O/genética
Proteus/imunologia
[Mh] Termos MeSH secundário: Reação em Cadeia da Polimerase
Proteus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (O Antigens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183267


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[PMID]:28700747
[Au] Autor:Borgdorff H; van der Veer C; van Houdt R; Alberts CJ; de Vries HJ; Bruisten SM; Snijder MB; Prins M; Geerlings SE; Schim van der Loeff MF; van de Wijgert JHHM
[Ad] Endereço:Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands.
[Ti] Título:The association between ethnicity and vaginal microbiota composition in Amsterdam, the Netherlands.
[So] Source:PLoS One;12(7):e0181135, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate whether ethnicity is independently associated with vaginal microbiota (VMB) composition in women living in Amsterdam, the Netherlands, as has been shown for American women. METHODS: Women (18-34 years, non-pregnant, N = 610) representing the six largest ethnic groups (Dutch, African Surinamese, South-Asian Surinamese, Turkish, Moroccan, and Ghanaian) were sampled from the population-based HELIUS study. Sampling was performed irrespective of health status or healthcare seeking behavior. DNA was extracted from self-sampled vaginal swabs and sequenced by Illumina MiSeq (16S rRNA gene V3-V4 region). RESULTS: The overall prevalence of VMBs not dominated by lactobacilli was 38.5%: 32.2% had a VMB resembling bacterial vaginosis and another 6.2% had a VMB dominated by Bifidobacteriaceae (not including Gardnerella vaginalis), Corynebacterium, or pathobionts (streptococci, staphylococci, Proteus or Enterobacteriaceae). The most prevalent VMB in ethnically Dutch women was a Lactobacillus crispatus-dominated VMB, in African Surinamese and Ghanaian women a polybacterial G. vaginalis-containing VMB, and in the other ethnic groups a L. iners-dominated VMB. After adjustment for sociodemographic, behavioral and clinical factors, African Surinamese ethnicity (adjusted odds ratio (aOR) 5.1, 95% confidence interval (CI) 2.1-12.0) and Ghanaian ethnicity (aOR 4.8, 95% CI 1.8-12.6) were associated with having a polybacterial G. vaginalis-containing VMB, and African Surinamese ethnicity with a L. iners-dominated VMB (aOR 2.8, 95% CI 1.2-6.2). Shorter steady relationship duration, inconsistent condom use with casual partners, and not using hormonal contraception were also associated with having a polybacterial G. vaginalis-containing VMB, but human papillomavirus infection was not. Other sexually transmitted infections were uncommon. CONCLUSIONS: The overall prevalence of having a VMB not dominated by lactobacilli in this population-based cohort of women aged 18-34 years in Amsterdam was high (38.5%), and women of sub-Saharan African descent were significantly more likely to have a polybacterial G. vaginalis-containing VMB than Dutch women independent of modifiable behaviors.
[Mh] Termos MeSH primário: Microbiota/fisiologia
Vagina/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Bifidobacterium/genética
Bifidobacterium/fisiologia
Corynebacterium/genética
Corynebacterium/fisiologia
Enterobacteriaceae/genética
Enterobacteriaceae/fisiologia
Feminino
Seres Humanos
Lactobacillus/genética
Lactobacillus/fisiologia
Microbiota/genética
Países Baixos
Proteus/genética
Proteus/fisiologia
RNA Ribossômico 16S/genética
Staphylococcus/genética
Staphylococcus/fisiologia
Streptococcus/genética
Streptococcus/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181135


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[PMID]:28129383
[Au] Autor:Vörös J; Márton O; Schmidt BR; Gál JT; Jelic D
[Ad] Endereço:Department of Zoology, Hungarian Natural History Museum, Budapest, Hungary.
[Ti] Título:Surveying Europe's Only Cave-Dwelling Chordate Species (Proteus anguinus) Using Environmental DNA.
[So] Source:PLoS One;12(1):e0170945, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In surveillance of subterranean fauna, especially in the case of rare or elusive aquatic species, traditional techniques used for epigean species are often not feasible. We developed a non-invasive survey method based on environmental DNA (eDNA) to detect the presence of the red-listed cave-dwelling amphibian, Proteus anguinus, in the caves of the Dinaric Karst. We tested the method in fifteen caves in Croatia, from which the species was previously recorded or expected to occur. We successfully confirmed the presence of P. anguinus from ten caves and detected the species for the first time in five others. Using a hierarchical occupancy model we compared the availability and detection probability of eDNA of two water sampling methods, filtration and precipitation. The statistical analysis showed that both availability and detection probability depended on the method and estimates for both probabilities were higher using filter samples than for precipitation samples. Combining reliable field and laboratory methods with robust statistical modeling will give the best estimates of species occurrence.
[Mh] Termos MeSH primário: DNA/genética
Proteus/genética
[Mh] Termos MeSH secundário: Anfíbios/genética
Animais
Cavernas
Croácia
DNA/química
DNA/isolamento & purificação
Europa (Continente)
Metagenômica
Proteus/química
Especificidade da Espécie
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170945


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[PMID]:28034519
[Au] Autor:Moy S; Sharma R
[Ad] Endereço:Department of Pharmacy, State University of New York (SUNY), Downstate Medical Center, Brooklyn, New York. Electronic address: Stanley.Moy@downstate.edu.
[Ti] Título:Treatment Outcomes in Infections Caused by "SPICE" (Serratia, Pseudomonas, Indole-positive Proteus, Citrobacter, and Enterobacter) Organisms: Carbapenem versus Noncarbapenem Regimens.
[So] Source:Clin Ther;39(1):170-176, 2017 Jan.
[Is] ISSN:1879-114X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Techniques used to identify AmpC ß-lactamases in SPICE (Serratia, Pseudomonas, indole-positive Proteus, Citrobacter, and Enterobacter) organisms are not yet optimized for the clinical laboratory and are not routinely used. Clinicians are often left with an uncertainty on the choice of antibiotic when a SPICE organism is isolated. The purpose of this study was to evaluate the outcomes of carbapenem versus noncarbapenem regimens in treating bacteremia or urinary tract infection from a SPICE organism in clinical practice. METHODS: This single-center, retrospective, cohort study analyzed data from adult patients who had clinical infection with a SPICE organism isolated from blood or urine cultures. Patients were assigned to a carbapenem- or noncarbapenem-treated group. The primary end point was clinical response, defined as a resolution of signs and symptoms of infection at the end of therapy. FINDINGS: A total of 332 patients were assessed, and 145 patients met the inclusion criteria for the study. There were 20 patients who received a carbapenem, while 125 received a noncarbapenem regimen. The percentage of patients who were bacteremic was 46.2%. Clinical response overall was achieved in 80% of patients on a carbapenem versus 90.3% of patients on a noncarbapenem regimen (P = 0.24). The rate of microbiologic cure was 90% in patients on a carbapenem versus 91.2% in patients on a noncarbapenem regimen (P = 1). IMPLICATIONS: In this study in patients treated for infection with a SPICE organism in clinical practice, the rates of clinical response did not differ significantly between the carbapenem and noncarbapenem groups. Current CLSI breakpoints set for SPICE organisms may still be reliable and may not require additional testing for AmpC ß-lactamases.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Bacteriemia/tratamento farmacológico
Carbapenêmicos/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Proteínas de Bactérias/metabolismo
Citrobacter/isolamento & purificação
Enterobacter/isolamento & purificação
Feminino
Seres Humanos
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Proteus/isolamento & purificação
Pseudomonas/isolamento & purificação
Estudos Retrospectivos
Serratia/isolamento & purificação
beta-Lactamases/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Carbapenems); EC 3.5.2.6 (AmpC beta-lactamases); EC 3.5.2.6 (beta-Lactamases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE


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[PMID]:27889698
[Au] Autor:Pretorius E; Akeredolu OO; Soma P; Kell DB
[Ad] Endereço:1 Department of Physiology, Faculty of Health Sciences, University of Pretoria, Arcadia, Pretoria 0007, South Africa.
[Ti] Título:Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability.
[So] Source:Exp Biol Med (Maywood);242(4):355-373, 2017 Feb.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We review the evidence that infectious agents, including those that become dormant within the host, have a major role to play in much of the etiology of rheumatoid arthritis and the inflammation that is its hallmark. This occurs in particular because they can produce cross-reactive (auto-)antigens, as well as potent inflammagens such as lipopolysaccharide that can themselves catalyze further inflammagenesis, including via ß-amyloid formation. A series of observables coexist in many chronic, inflammatory diseases as well as rheumatoid arthritis. They include iron dysregulation, hypercoagulability, anomalous morphologies of host erythrocytes, and microparticle formation. Iron dysregulation may be responsible for the periodic regrowth and resuscitation of the dormant bacteria, with concomitant inflammagen production. The present systems biology analysis benefits from the philosophical idea of "coherence," that reflects the principle that if a series of ostensibly unrelated findings are brought together into a self-consistent narrative, that narrative is thereby strengthened. As such, we provide a coherent and testable narrative for the major involvement of (often dormant) bacteria in rheumatoid arthritis.
[Mh] Termos MeSH primário: Artrite Reumatoide/microbiologia
Autoantígenos/imunologia
Micropartículas Derivadas de Células/imunologia
Infecções por Proteus/patologia
Proteus/imunologia
Trombofilia/microbiologia
Infecções Urinárias/patologia
[Mh] Termos MeSH secundário: Artrite Reumatoide/etiologia
Artrite Reumatoide/imunologia
Feminino
Seres Humanos
Inflamação/imunologia
Lipopolissacarídeos/imunologia
Masculino
Meia-Idade
Estresse Oxidativo/imunologia
Estresse Oxidativo/fisiologia
Infecções por Proteus/microbiologia
Trombofilia/imunologia
Infecções Urinárias/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Autoantigens); 0 (Lipopolysaccharides)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161128
[St] Status:MEDLINE
[do] DOI:10.1177/1535370216681549


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[PMID]:27466174
[Au] Autor:Wright EK; Kamm MA; Wagner J; Teo SM; Cruz P; Hamilton AL; Ritchie KJ; Inouye M; Kirkwood CD
[Ad] Endereço:Department of Gastroenterology, St Vincent's Hospital and University of Melbourne, Melbourne, VIC, Australia.
[Ti] Título:Microbial Factors Associated with Postoperative Crohn's Disease Recurrence.
[So] Source:J Crohns Colitis;11(2):191-203, 2017 Feb.
[Is] ISSN:1876-4479
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: The intestinal microbiota is a key antigenic driver in Crohn's disease [CD]. We aimed to identify changes in the gut microbiome associated with, and predictive of, disease recurrence and remission. METHODS: A total of 141 mucosal biopsy samples from 34 CD patients were obtained at surgical resection and at colonoscopy 6 and/or 18 months postoperatively; 28 control samples were obtained: 12 from healthy patients [healthy controls] and 16 from hemicolectomy patients [surgical controls]. Bacterial 16S ribosomal profiling was performed using the Illumina MiSeq platform. RESULTS: CD was associated with reduced alpha diversity when compared with healthy controls but not surgical controls [p < 0.001 and p = 0.666, respectively]. Beta diversity [composition] differed significantly between CD and both healthy [p < 0.001] and surgical [p = 0.022] controls, but did not differ significantly between those with and without endoscopic recurrence. There were significant taxonomic differences between recurrence and remission. Patients experiencing recurrence demonstrated elevated Proteus genera [p = 0.008] and reduced Faecalibacterium [p< 0.001]. Active smoking was associated with elevated levels of Proteus [p = 0.013] postoperatively. Low abundance of Faecalibacterium [< 0.1%] and detectable Proteus in the postoperative ileal mucosa was associated with a higher risk of recurrence (odds ratio [OR] 14 [1.7-110], p = 0.013 and 13 [1.1-150], p = 0.039, respectively) when corrected for smoking. A model of recurrence comprising the presence of Proteus, abundance of Faecalibacterium, and smoking status showed moderate accuracy (area under the curve [AUC] 0.740, 95% confidence interval [CI] [0.69-0.79]). CONCLUSIONS: CD is associated with a microbial signature distinct from health. Microbial factors and smoking independently influence postoperative CD recurrence. The genus Proteus may play a role in the development of CD.
[Mh] Termos MeSH primário: Colectomia
Doença de Crohn
Microbioma Gastrointestinal/fisiologia
Íleo
Complicações Pós-Operatórias
Fumar
[Mh] Termos MeSH secundário: Adulto
Colectomia/efeitos adversos
Colectomia/métodos
Colonoscopia/métodos
Doença de Crohn/microbiologia
Doença de Crohn/patologia
Doença de Crohn/psicologia
Doença de Crohn/cirurgia
Feminino
Seres Humanos
Íleo/microbiologia
Íleo/patologia
Mucosa Intestinal/microbiologia
Mucosa Intestinal/patologia
Masculino
Meia-Idade
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/microbiologia
Complicações Pós-Operatórias/psicologia
Proteus/isolamento & purificação
Recidiva
Fatores de Risco
Fumar/epidemiologia
Fumar/fisiopatologia
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160729
[St] Status:MEDLINE
[do] DOI:10.1093/ecco-jcc/jjw136


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[PMID]:27121980
[Au] Autor:Salvadori M; Vercelli C; De Vito V; Dezzutto D; Bergagna S; Re G; Giorgi M
[Ad] Endereço:ExoticVet Veterinary Center, Pisa, Italy.
[Ti] Título:Pharmacokinetic and pharmacodynamic evaluations of a 10 mg/kg enrofloxacin intramuscular administration in bearded dragons (Pogona vitticeps): a preliminary assessment.
[So] Source:J Vet Pharmacol Ther;40(1):62-69, 2017 Jan.
[Is] ISSN:1365-2885
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Enrofloxacin (E) is commonly used in veterinary medicine. It is necessary to perform pharmacokinetic/dynamic studies to minimize the selection of resistant mutants of bacteria and extend the efficacy of antimicrobial agents. Eight healthy adult Pogona vitticeps were assigned into two groups of equal size and treated with a single intramuscular injection of E at 10 mg/kg. Blood samples were withdrawn at different scheduled times for each group, and rectal swabs were collected. E and ciprofloxacin (active metabolite) blood concentrations were quantified by an HPLC validated method, while the in vitro antimicrobial susceptibility was evaluated by the Kirby-Bauer disc diffusion susceptibility test. The pharmacokinetic profiles of E gave similar pharmacokinetic parameters irrespective of the collection time schedule. Bacteria isolation showed the presence of both E. coli, Salmonella enterica subspecies enterica and subspecies 3a, Proteus spp., and Pseudomonas spp. The majority of isolated colonies were sensitive to E, but the treatment did not reduce the number of bacteria in faeces. Results suggest that E is able to reach blood concentrations high enough to kill susceptible bacteria (MIC < 0.9 µg/mL), but at the same time does not significantly affect intestinal bacteria.
[Mh] Termos MeSH primário: Antibacterianos/farmacocinética
Fluoroquinolonas/farmacocinética
Lagartos/metabolismo
[Mh] Termos MeSH secundário: Animais
Antibacterianos/administração & dosagem
Antibacterianos/sangue
Antibacterianos/farmacologia
Cromatografia Líquida de Alta Pressão/veterinária
Ciprofloxacino/sangue
Escherichia coli/efeitos dos fármacos
Feminino
Fluoroquinolonas/administração & dosagem
Fluoroquinolonas/sangue
Fluoroquinolonas/farmacologia
Injeções Intramusculares/veterinária
Lagartos/sangue
Masculino
Testes de Sensibilidade Microbiana/veterinária
Proteus/efeitos dos fármacos
Pseudomonas/efeitos dos fármacos
Salmonella enterica/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fluoroquinolones); 3DX3XEK1BN (enrofloxacin); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.1111/jvp.12320


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[PMID]:27998162
[Au] Autor:Ullah O; Khan A; Ambreen A; Ahmad I; Akhtar T; Gandapor AJ; Khan AM
[Ad] Endereço:Senior Research Officer, Pakistan Health Research Council, Research Centre, Khyber Medical College Peshawar, Pakistan.
[Ti] Título:Antibiotic Sensitivity pattern of Bacterial Isolates of Neonatal Septicemia in Peshawar, Pakistan.
[So] Source:Arch Iran Med;19(12):866-869, 2016 Dec.
[Is] ISSN:1735-3947
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Septicemia plays an important role in neonatal morbidity and mortality, especially in developing countries. OBJECTIVE: To investigate the bacterial pathogens causing neonatal sepsis and their antibiotic susceptibility profile. METHODOLOGY: A total of 2,685 neonates aged 0-28 days were included in the study. Blood from each neonate was cultured and isolates were identified using standard biochemical tests. Antibiotic sensitivity pattern was analyzed using modified Kirby-Bauer disc diffusion method. RESULTS: Blood culture positivity was observed in 1,534 (57.1%) samples. Most of the cases (1089 counts - 71%) were of early onset sepsis while 445 (29%) were of late onset sepsis. The incidence of sepsis was higher in males 856 (55.8%) than females 678 (44.2%) with a 1:2 ratio. Similarly, 58.3% of septicemic patients were neonates with low birth weights. Twelve hundred and six (78.6%) isolates were gram negative while 328 (23.4%) were gram positive bacteria. E. coli was the dominant pathogen seen in 811 (52.8%) followed by Staphylococcus aureus 300 (19.5%), Pseudomonas 199 (13%), Klebsiella 102 (6.7%), Proteus 87 (5.7%), Staphylococcus epidermidis 28(1.8%) and Salmonella in 7 (0.5%) samples. All bacterial isolates showed high sensitivity to Imipenem, Enoxacin, Ofloxacin and Ciprofloxacin while low sensitivity was observed for other antibiotics (n = 16). The Proteus species showed high level of multiple resistances to all antibiotics (5.9%). CONCLUSION: Imipenem, Enoxacin, Ofloxacin and Ciprofloxacin can be used as an effective antibiotic regimen for treatment of bacterial sepsis in neonates.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana Múltipla
Bactérias Gram-Negativas/efeitos dos fármacos
Infecções por Bactérias Gram-Negativas/microbiologia
Sepse Neonatal/microbiologia
Infecções Estafilocócicas/microbiologia
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus epidermidis/efeitos dos fármacos
[Mh] Termos MeSH secundário: Ciprofloxacino/farmacologia
Farmacorresistência Bacteriana
Enoxacino/farmacologia
Escherichia coli/efeitos dos fármacos
Escherichia coli/fisiologia
Infecções por Escherichia coli/microbiologia
Feminino
Bactérias Gram-Negativas/fisiologia
Seres Humanos
Imipenem/farmacologia
Recém-Nascido de Baixo Peso
Recém-Nascido
Klebsiella/efeitos dos fármacos
Klebsiella/fisiologia
Infecções por Klebsiella/microbiologia
Masculino
Testes de Sensibilidade Microbiana
Ofloxacino/farmacologia
Paquistão
Proteus/efeitos dos fármacos
Proteus/fisiologia
Infecções por Proteus/microbiologia
Pseudomonas/efeitos dos fármacos
Pseudomonas/fisiologia
Infecções por Pseudomonas/microbiologia
Staphylococcus aureus/fisiologia
Staphylococcus epidermidis/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 325OGW249P (Enoxacin); 5E8K9I0O4U (Ciprofloxacin); 71OTZ9ZE0A (Imipenem); A4P49JAZ9H (Ofloxacin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:0161912/AIM.009



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