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  1 / 17534 MEDLINE  
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[PMID]:28456782
[Au] Autor:Lee CH; Nishikawa T; Kaneda Y
[Ad] Endereço:Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
[Ti] Título:Salmonella mediated the hemagglutinating virus of Japan-envelope transfer suppresses tumor growth.
[So] Source:Oncotarget;8(21):35048-35060, 2017 May 23.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Salmonella can target to tumor microenvironments after systemic treatment. The hemagglutinating virus of Japan-envelope (HVJ-E) induced apoptosis in tumor cells without toxicity in normal cells. Current HVJ-E therapeutic strategies, aimed at using HVJ-E for intratumor treatment, have shown great promise in animal models but have achieved only limited systemic treatment. The purpose of this study was to investigate the modulation of the anti-tumor efficiency of HVJ-E by coating the particles with poly (allylamine hydrochloride) (PAH), designated as P-HVJ-E. Treatment with P-HVJ-E resulted in decreased hemagglutinating activity and maintained tumor cell-selective apoptosis and anti-tumor immunity. The use of Salmonella as a coating for P-HVJ-E (PHS) enhanced the antitumor activity and maintained the tumor-targeting activity. Treatment with PHS resulted in delayed tumor growth in tumor-bearing mice. Furthermore, a Western blot assay of the tumors revealed that HVJ-E targeted to the tumor after systemic treatment with PHS. These results indicate that Salmonella coating viral particles may provide a new approach for tumor therapy.
[Mh] Termos MeSH primário: Neoplasias Experimentais/tratamento farmacológico
Poliaminas/química
Salmonella/fisiologia
Vírus Sendai/metabolismo
Proteínas do Envelope Viral/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Seres Humanos
Camundongos
Microambiente Tumoral
Proteínas do Envelope Viral/química
Proteínas do Envelope Viral/farmacologia
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polyamines); 0 (Viral Envelope Proteins); 30551-89-4 (polyallylamine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.17037


  2 / 17534 MEDLINE  
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[PMID]:28468915
[Au] Autor:Mei Y; Zhao L; Liu Y; Gong H; Song Y; Lei L; Zhu Y; Jin Z; Ma S; Hu B; Sun Q; Liu H
[Ad] Endereço:Institute of Blood and Marrow Transplantation, Department of Hematology, Collaborative Innovation Center of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, P.R. China.
[Ti] Título:Combining DNA Vaccine and AIDA-1 in Attenuated Activates Tumor-Specific CD4 and CD8 T-cell Responses.
[So] Source:Cancer Immunol Res;5(6):503-514, 2017 Jun.
[Is] ISSN:2326-6074
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Stimulation of tumor-specific responses in both CD4 and CD8 T cells has been a challenge for effective tumor vaccines. We designed a vaccine vector containing the AIDA-1 autotransporter and DNA vaccine elements, generating a murine melanoma vaccine that was delivered by the attenuated strain SL7207. Growth of murine subcutaneous melanoma was significantly inhibited by intranasal immunization with the tumor vaccine. The vaccine activated tumor-specific CD4 and CD8 T-cell responses, with increased T-cell proliferation, tumor antigen-specific Th1 cytokine production, increased percentages of tetramer positive cells, and cytotoxicity. CD4 or CD8 T-cell depletion resulted in the loss of antitumor activity of the tumor vaccine, suggesting that the efficacy of the vaccine was dependent on both CD4 and CD8 T cells. Lung metastasis of the tumor was also inhibited by vaccine treatment. Similarly, the percentages of tumor-specific Th1 cytokine production by CD4 and CD8 T cells in the spleen, tumor, and bronchoalveolar lavage were increased after vaccine treatment. Tumor-specific proliferation of CD4 and CD8 T cells was also promoted by the vaccine. Tetramer staining and cytotoxicity assay showed enhanced tumor-specific CD8 T-cell response after vaccine treatment. Therefore, the tumor vaccine could activate both tumor-specific CD4 and CD8 T-cell responses. This vaccine strategy may be widely applicable to the development of oral or nasal vaccines against tumors. .
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Vacinas Anticâncer/administração & dosagem
Neoplasias/imunologia
Salmonella
Vacinas de DNA/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Proteínas de Transporte
Linhagem Celular Tumoral
Feminino
Camundongos Endogâmicos C57BL
Neoplasias/patologia
Neoplasias/terapia
Salmonella/genética
Carga Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ANKS1B protein, human); 0 (Cancer Vaccines); 0 (Carrier Proteins); 0 (Vaccines, DNA)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1158/2326-6066.CIR-16-0240-T


  3 / 17534 MEDLINE  
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[PMID]:29200844
[Au] Autor:Al-Hada NM; Mohamed Kamari H; Abdullah CAC; Saion E; Shaari AH; Talib ZA; Matori KA
[Ad] Endereço:Department of Physics, Faculty of Science.
[Ti] Título:Down-top nanofabrication of binary (CdO) (ZnO) nanoparticles and their antibacterial activity.
[So] Source:Int J Nanomedicine;12:8309-8323, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:In the present study, binary oxide (cadmium oxide [CdO]) (zinc oxide [ZnO]) nanoparticles (NPs) at different concentrations of precursor in calcination temperature were prepared using thermal treatment technique. Cadmium and zinc nitrates (source of cadmium and zinc) with polyvinylpyrrolidone (capping agent) have been used to prepare (CdO) (ZnO) NPs samples. The sample was characterized by X-ray diffraction (XRD), scanning electron microscopy, energy-dispersive X-ray (EDX), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy. XRD patterns analysis revealed that NPs were formed after calcination, which showed a cubic and hexagonal crystalline structure of (CdO) (ZnO) NPs. The phase analysis using EDX spectroscopy and FTIR spectroscopy confirmed the presence of Cd and Zn as the original compounds of prepared (CdO) (ZnO) NP samples. The average particle size of the samples increased from 14 to 33 nm as the concentration of precursor increased from x=0.20 to x=0.80, as observed by TEM results. The surface composition and valance state of the prepared product NPs were determined by X-ray photoelectron spectroscopy (XPS) analyses. Diffuse UV-visible reflectance spectra were used to determine the optical band gap through the Kubelka-Munk equation; the energy band gap was found to decrease for CdO from 2.92 to 2.82 eV and for ZnO from 3.22 to 3.11 eV with increasing x value. Additionally, photoluminescence (PL) spectra revealed that the intensity in PL increased with an increase in particle size. In addition, the antibacterial activity of binary oxide NP was carried out in vitro against ATCC 25922 Gram (-ve), ATCC 10708, and UPMC 1175 Gram (+ve). This study indicated that the zone of inhibition of 21 mm has good antibacterial activity toward the Gram-positive UPMC 1175.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Compostos de Cádmio/química
Nanopartículas/química
Óxidos/química
Óxido de Zinco/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Bacillus subtilis/efeitos dos fármacos
Compostos de Cádmio/farmacologia
Avaliação Pré-Clínica de Medicamentos/métodos
Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Óxidos/farmacologia
Tamanho da Partícula
Espectroscopia Fotoeletrônica
Salmonella/efeitos dos fármacos
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
Óxido de Zinco/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cadmium Compounds); 0 (Oxides); 0H3KWS8KJ3 (cadmium oxide); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S150405


  4 / 17534 MEDLINE  
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[PMID]:29424211
[Au] Autor:Rakhmanin YA; Zhuravlev PV; Aleshnya VV; Panasovets OV
[Ti] Título:[Application of the new culture medium for the isolation of Salmonella from water bodies to assess the epidemic safety of water use. Gigiena i Sanitaria (Hygiene and Sanitation, Russian)].
[So] Source:Gig Sanit;95(5):483-90, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There was developed a liquid storage medium for the isolation of bacteria of genus Salmonella from water bodies (The culture medium for the accumulation of Salmonella, ready to use, "RNS"), providing the accumulation of Salmonella from different serogroups, inhibiting the growth of accompanying microflora, allowing to obtain objective information about the extent of bacterial contamination of water bodies. Medium is by nature of a solution for microbiological purposes which is produced by mixing the components with consequentfiltration and sterilization. In an experimental way there were chosen optimal ratios of the nutrient medium ingredients: extract offodder yeast in an amount of 4.55.0 g/l, sodium hydroxide - to 1.3-1.4 g/l, potassium phosphate - 8.6-8.8 g/l. The medium is a sterile, clear liquid, green in color, medium pH is 6.4 to 6.8, amine nitrogen - from 0.05 to 0.1%. Designed medium for accumulation is sensitivity, it ensures the growth of the test strains of salmonella at seeding of single cells in that favorably differs from similar media used in public health practice at the present time. The smallest time for the accumulation of biomass of Salmonella accounts of 6 hours, the optimal time is 24 hours. Incubation of crops is produced at 37 °C. Cultures of Salmonella at seeding in the developed medium retain their biological properties. Developed medium in terms of sensitivity is superior to magnesian and selenite media.
[Mh] Termos MeSH primário: Técnicas Bacteriológicas
Meios de Cultura/farmacologia
Salmonella/isolamento & purificação
[Mh] Termos MeSH secundário: Técnicas Bacteriológicas/instrumentação
Técnicas Bacteriológicas/métodos
Monitoramento Epidemiológico
Seres Humanos
Reprodutibilidade dos Testes
Microbiologia da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


  5 / 17534 MEDLINE  
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[PMID]:29447692
[Au] Autor:Vázquez-Torres A
[Ad] Endereço:Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA; Veterans Affairs Eastern Colorado Health Care System, Denver, CO 80220, USA. Electronic address: andres.vazquez-torres@ucdenver.edu.
[Ti] Título:Less Is Best in the Convergent Evolution of Typhoidal Salmonella.
[So] Source:Cell Host Microbe;23(2):151-153, 2018 02 14.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Related works in this issue of Cell Host & Microbe (Bronner et al., 2018) and in a recent issue of Cell Reports (Hiyoshi et al., 2018) demonstrate how loss-of-function mutations in butyrate utilization and lipopolysaccharide O-antigen processing contribute to evasion of innate host defenses and the convergent evolution of distinct typhoidal Salmonella lineages.
[Mh] Termos MeSH primário: Infecções por Salmonella
Salmonella/genética
[Mh] Termos MeSH secundário: Lipopolissacarídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Lipopolysaccharides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


  6 / 17534 MEDLINE  
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[PMID]:29121500
[Au] Autor:Domesle KJ; Yang Q; Hammack TS; Ge B
[Ad] Endereço:Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
[Ti] Título:Validation of a Salmonella loop-mediated isothermal amplification assay in animal food.
[So] Source:Int J Food Microbiol;264:63-76, 2018 Jan 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Loop-mediated isothermal amplification (LAMP) has emerged as a promising alternative to PCR for pathogen detection in food testing and clinical diagnostics. This study aimed to validate a Salmonella LAMP method run on both turbidimetry (LAMP I) and fluorescence (LAMP II) platforms in representative animal food commodities. The U.S. Food and Drug Administration (FDA)'s culture-based Bacteriological Analytical Manual (BAM) method was used as the reference method and a real-time quantitative PCR (qPCR) assay was also performed. The method comparison study followed the FDA's microbiological methods validation guidelines, which align well with those from the AOAC International and ISO. Both LAMP assays were 100% specific among 300 strains (247 Salmonella of 185 serovars and 53 non-Salmonella) tested. The detection limits ranged from 1.3 to 28 cells for six Salmonella strains of various serovars. Six commodities consisting of four animal feed items (cattle feed, chicken feed, horse feed, and swine feed) and two pet food items (dry cat food and dry dog food) all yielded satisfactory results. Compared to the BAM method, the relative levels of detection (RLODs) for LAMP I ranged from 0.317 to 1 with a combined value of 0.610, while those for LAMP II ranged from 0.394 to 1.152 with a combined value of 0.783, which all fell within the acceptability limit (2.5) for an unpaired study. This also suggests that LAMP was more sensitive than the BAM method at detecting low-level Salmonella contamination in animal food and results were available 3days sooner. The performance of LAMP on both platforms was comparable to that of qPCR but notably faster, particularly LAMP II. Given the importance of Salmonella in animal food safety, the LAMP assays validated in this study holds great promise as a rapid, reliable, and robust method for routine screening of Salmonella in these commodities.
[Mh] Termos MeSH primário: Ração Animal/microbiologia
Contaminação de Alimentos/análise
Microbiologia de Alimentos/métodos
Técnicas de Amplificação de Ácido Nucleico/métodos
Salmonella/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Técnicas Bacteriológicas/métodos
Inocuidade dos Alimentos/métodos
Limite de Detecção
Reação em Cadeia da Polimerase em Tempo Real/métodos
Salmonella/classificação
Salmonella/genética
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171110
[St] Status:MEDLINE


  7 / 17534 MEDLINE  
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[PMID]:29328567
[Au] Autor:Bosnjak I; Zdravkovic N; Colovic S; Randelovic S; Galic N; Radojicic M; Sekler M; Aleksic-Kovacevic S; Krnjaic D
[Ti] Título:Neglected zoonosis: The prevalence of Salmonella spp. in pet reptiles in Serbia.
[So] Source:Vojnosanit Pregl;73(10):980-2, 2016 Oct.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Mh] Termos MeSH primário: Animais de Estimação/microbiologia
Répteis/microbiologia
Salmonelose Animal/transmissão
Salmonella/patogenicidade
Zoonoses/transmissão
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Fatores de Risco
Salmonelose Animal/diagnóstico
Salmonelose Animal/epidemiologia
Salmonelose Animal/microbiologia
Sérvia/epidemiologia
Zoonoses/diagnóstico
Zoonoses/epidemiologia
Zoonoses/microbiologia
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP160809222B


  8 / 17534 MEDLINE  
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[PMID]:28741960
[Au] Autor:Beuchat LR; Mann DA; Kelly CA; Ortega YR
[Ad] Endereço:Center for Food Safety and Department of Food Science and Technology, University of Georgia, 1109 Experiment Street, Griffin, Georgia 30223-1797, USA.
[Ti] Título:Retention of Viability of Salmonella in Sucrose as Affected by Type of Inoculum, Water Activity, and Storage Temperature.
[So] Source:J Food Prot;80(9):1408-1414, 2017 09.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Outbreaks of salmonellosis have been associated with consumption of high-sugar, low-water activity (a ) foods. The study reported here was focused on determining the effect of storage temperature (5 and 25°C) on survival of initially high and low levels of Salmonella in dry-inoculated sucrose (a 0.26 ± 0.01 to 0.54 ± 0.01) and wet-inoculated sucrose (a 0.24 ± 0.01 to 0.44 ± 0.04) over a 52-week period. With the exception of dry-inoculated sucrose at a 0.26, Salmonella survived for 52 weeks in dry- and wet-inoculated sucrose stored at 5 and 25°C. Retention of viability was clearly favored in sucrose stored at 5°C compared with 25°C, regardless of level or type of inoculum or a . Survival at 5°C was not affected by a . Initial high-inoculum counts of 5.18 and 5.25 log CFU/g of dry-inoculated sucrose (a 0.26 and 0.54, respectively) stored for 52 weeks at 5°C decreased by 0.56 and 0.53 log CFU/g; counts decreased by >4.18 and >4.25 log CFU/g in samples stored at 25°C. Inactivation rates in wet-inoculated sucrose were similar to those in dry-inoculated sucrose; however, a trend toward higher persistence of Salmonella in dry- versus wet-inoculated sucrose suggests there was a higher proportion of cells in the wet inoculum with low tolerance to osmotic stress. Survival patterns were similar in sucrose initially containing a low level of Salmonella (2.26 to 2.91 log CFU/g). The pathogen was recovered from low-inoculated sucrose stored at 5°C for 52 weeks regardless of type of inoculum or a and from dry-inoculated sucrose (a 0.54) and wet-inoculated sucrose (a 0.24) stored at 25°C for 12 and 26 weeks, respectively. Results emphasize the importance of preventing contamination of sucrose intended for use as an ingredient in foods not subjected to a treatment that would be lethal to Salmonella.
[Mh] Termos MeSH primário: Manipulação de Alimentos/métodos
Viabilidade Microbiana
Salmonella/crescimento & desenvolvimento
Sacarose
[Mh] Termos MeSH secundário: Contagem de Colônia Microbiana
Microbiologia de Alimentos
Temperatura Ambiente
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 57-50-1 (Sucrose)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-16-537


  9 / 17534 MEDLINE  
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[PMID]:29229393
[Au] Autor:Sakai T; Inoue Y; Terahara N; Namba K; Minamino T
[Ad] Endereço:Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadoaka, Suita, Osaka 565-0871, Japan.
[Ti] Título:A triangular loop of domain D1 of FlgE is essential for hook assembly but not for the mechanical function.
[So] Source:Biochem Biophys Res Commun;495(2):1789-1794, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The bacterial flagellar hook is a short, curved tubular structure made of FlgE. The hook connects the basal body as a rotary motor and the filament as a helical propeller and functions as a universal joint to smoothly transmit torque produced by the motor to the filament. Salmonella FlgE consists of D0, Dc, D1 and D2 domains. Axial interactions between a triangular loop of domain D1 (D1-loop) and domain D2 are postulated to be responsible for hook supercoiling. In contrast, Bacillus FlgE lacks the D1-loop and domain D2. Here, to clarify the roles of the D1-loop and domain D2 in the mechanical function, we carried out deletion analysis of Salmonella FlgE. A deletion of the D1-loop conferred a loss-of-function phenotype whereas that of domain D2 did not. The D1-loop deletion inhibited hook polymerization. Suppressor mutations of the D1-loop deletion was located within FlgD, which acts as the hook cap to promote hook assembly. This suggests a possible interaction between the D1-loop of FlgE and FlgD. Suppressor mutant cells produced straight hooks, but retained the ability to form a flagellar bundle behind a cell body, suggesting that the loop deletion does not affect the bending flexibility of the Salmonella hook.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Proteínas de Bactérias/metabolismo
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Flagelos/química
Flagelos/fisiologia
Flagelos/ultraestrutura
Genes Bacterianos
Modelos Moleculares
Proteínas Motores Moleculares/química
Proteínas Motores Moleculares/genética
Proteínas Motores Moleculares/metabolismo
Mutação
Domínios Proteicos
Multimerização Proteica
Salmonella/genética
Salmonella/fisiologia
Deleção de Sequência
Homologia Estrutural de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (FlgE protein, Bacteria); 0 (Molecular Motor Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


  10 / 17534 MEDLINE  
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[PMID]:29216183
[Au] Autor:MacLennan CA; Msefula CL; Gondwe EN; Gilchrist JJ; Pensulo P; Mandala WL; Mwimaniwa G; Banda M; Kenny J; Wilson LK; Phiri A; MacLennan JM; Molyneux EM; Molyneux ME; Graham SM
[Ad] Endereço:Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
[Ti] Título:Presentation of life-threatening invasive nontyphoidal Salmonella disease in Malawian children: A prospective observational study.
[So] Source:PLoS Negl Trop Dis;11(12):e0006027, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nontyphoidal Salmonellae commonly cause invasive disease in African children that is often fatal. The clinical diagnosis of these infections is hampered by the absence of a clear clinical syndrome. Drug resistance means that empirical antibiotic therapy is often ineffective and currently no vaccine is available. The study objective was to identify risk factors for mortality among children presenting to hospital with invasive Salmonella disease in Africa. We conducted a prospective study enrolling consecutive children with microbiologically-confirmed invasive Salmonella disease admitted to Queen Elizabeth Central Hospital, Blantyre, in 2006. Data on clinical presentation, co-morbidities and outcome were used to identify children at risk of inpatient mortality through logistic-regression modeling. Over one calendar year, 263 consecutive children presented with invasive Salmonella disease. Median age was 16 months (range 0-15 years) and 52/256 children (20%; 95%CI 15-25%) died. Nontyphoidal serovars caused 248/263 (94%) of cases. 211/259 (81%) of isolates were multi-drug resistant. 251/263 children presented with bacteremia, 6 with meningitis and 6 with both. Respiratory symptoms were present in 184/240 (77%; 95%CI 71-82%), 123/240 (51%; 95%CI 45-58%) had gastrointestinal symptoms and 101/240 (42%; 95%CI 36-49%) had an overlapping clinical syndrome. Presentation at <7 months (OR 10.0; 95%CI 2.8-35.1), dyspnea (OR 4.2; 95%CI 1.5-12.0) and HIV infection (OR 3.3; 95%CI 1.1-10.2) were independent risk factors for inpatient mortality. Invasive Salmonella disease in Malawi is characterized by high mortality and prevalence of multi-drug resistant isolates, along with non-specific presentation. Young infants, children with dyspnea and HIV-infected children bear a disproportionate burden of the Salmonella-associated mortality in Malawi. Strategies to improve prevention, diagnosis and management of invasive Salmonella disease should be targeted at these children.
[Mh] Termos MeSH primário: Bacteriemia/epidemiologia
Infecções por HIV/complicações
Meningites Bacterianas/epidemiologia
Infecções por Salmonella/epidemiologia
Salmonella/imunologia
[Mh] Termos MeSH secundário: Adolescente
Bacteriemia/etiologia
Bacteriemia/microbiologia
Bacteriemia/mortalidade
Criança
Pré-Escolar
Farmacorresistência Bacteriana Múltipla
Feminino
Seres Humanos
Lactente
Modelos Logísticos
Malaui/epidemiologia
Masculino
Meningites Bacterianas/etiologia
Meningites Bacterianas/microbiologia
Meningites Bacterianas/mortalidade
Prevalência
Estudos Prospectivos
Fatores de Risco
Salmonella/isolamento & purificação
Infecções por Salmonella/etiologia
Infecções por Salmonella/microbiologia
Infecções por Salmonella/mortalidade
Sorogrupo
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006027



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