Base de dados : MEDLINE
Pesquisa : B03.440.450.600.224.500 [Categoria DeCS]
Referências encontradas : 2568 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 257 ir para página                         

  1 / 2568 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29321009
[Au] Autor:Ben Lagha A; LeBel G; Grenier D
[Ad] Endereço:Oral Ecology Research Group (GREB), Faculty of Dentistry, Université Laval, 2420 Rue de la Terrasse, Quebec City, QC, G1V 0A6, Canada.
[Ti] Título:Dual action of highbush blueberry proanthocyanidins on Aggregatibacter actinomycetemcomitans and the host inflammatory response.
[So] Source:BMC Complement Altern Med;18(1):10, 2018 Jan 10.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The highbush blueberry (Vaccinium corymbosum) has a beneficial effect on several aspects of human health. The present study investigated the effects of highbush blueberry proanthocyanidins (PACs) on the virulence properties of Aggregatibacter actinomycetemcomitans and macrophage-associated inflammatory responses. METHODS: PACs were isolated from frozen highbush blueberries using solid-phase chromatography. A microplate dilution assay was performed to determine the effect of highbush blueberry PACs on A. actinomycetemcomitans growth as well as biofilm formation stained with crystal violet. Tight junction integrity of oral keratinocytes was assessed by measuring the transepithelial electrical resistance (TER), while macrophage viability was determined with a colorimetric MTT assay. Pro-inflammatory cytokine and MMP secretion by A. actinomycetemcomitans-stimulated macrophages was quantified by ELISA. The U937-3xκB-LUC monocyte cell line transfected with a luciferase reporter gene was used to monitor NF-κB activation. RESULTS: Highbush blueberry PACs reduced the growth of A. actinomycetemcomitans and prevented biofilm formation at sub-inhibitory concentrations. The treatment of pre-formed biofilms with the PACs resulted in a loss of bacterial viability. The antibacterial activity of the PACs appeared to involve damage to the bacterial cell membrane. The PACs protected the oral keratinocytes barrier integrity from damage caused by A. actinomycetemcomitans. The PACs also protected macrophages from the deleterious effect of leukotoxin Ltx-A and dose-dependently inhibited the secretion of pro-inflammatory cytokines (IL-1ß, IL-6, CXCL8, TNF-α), matrix metalloproteinases (MMP-3, MMP-9), and sTREM-1 by A. actinomycetemcomitans-treated macrophages. The PACs also inhibited the activation of the NF-κB signaling pathway. CONCLUSION: The antibacterial and anti-inflammatory properties of highbush blueberry PACs as well as their ability to protect the oral keratinocyte barrier and neutralize leukotoxin activity suggest that they may be promising candidates as novel therapeutic agents.
[Mh] Termos MeSH primário: Aggregatibacter actinomycetemcomitans
Mirtilos Azuis (Planta)/química
Interações Hospedeiro-Patógeno
Extratos Vegetais/farmacologia
Proantocianidinas/farmacologia
[Mh] Termos MeSH secundário: Aggregatibacter actinomycetemcomitans/efeitos dos fármacos
Aggregatibacter actinomycetemcomitans/imunologia
Citocinas/metabolismo
Interações Hospedeiro-Patógeno/efeitos dos fármacos
Interações Hospedeiro-Patógeno/imunologia
Seres Humanos
Queratinócitos/citologia
Queratinócitos/efeitos dos fármacos
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
NF-kappa B/metabolismo
Periodontite
Extratos Vegetais/química
Proantocianidinas/química
Junções Íntimas
Células U937
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Proanthocyanidins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2072-x


  2 / 2568 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29206238
[Au] Autor:Nomura Y; Morozumi T; Nakagawa T; Sugaya T; Kawanami M; Suzuki F; Takahashi K; Abe Y; Sato S; Makino-Oi A; Saito A; Takano S; Minabe M; Nakayama Y; Ogata Y; Kobayashi H; Izumi Y; Sugano N; Ito K; Sekino S; Numabe Y; Fukaya C; Yoshinari N; Fukuda M; Noguchi T; Kono T; Umeda M; Fujise O; Nishimura F; Yoshimura A; Hara Y; Nakamura T; Noguchi K; Kakuta E; Hanada N; Takashiba S; Amitani Y; Yoshie H
[Ad] Endereço:Department of Translational Research, Tsurumi University School of Dental Medicine, Yokohama, Japan.
[Ti] Título:Site-level progression of periodontal disease during a follow-up period.
[So] Source:PLoS One;12(12):e0188670, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Periodontal disease is assessed and its progression is determined via observations on a site-by-site basis. Periodontal data are complex and structured in multiple levels; thus, applying a summary statistical approach (i.e., the mean) for site-level evaluations results in loss of information. Previous studies have shown the availability of mixed effects modeling. However, clinically beneficial information on the progression of periodontal disease during the follow-up period is not available. We conducted a multicenter prospective cohort study. Using mixed effects modeling, we analyzed 18,834 sites distributed on 3,139 teeth in 124 patients, and data were collected 5 times over a 24-month follow-up period. The change in the clinical attachment level (CAL) was used as the outcome variable. The CAL at baseline was an important determinant of the CAL changes, which varied widely according to the tooth surface. The salivary levels of periodontal pathogens, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, were affected by CAL progression. "Linear"- and "burst"-type patterns of CAL progression occurred simultaneously within the same patient. More than half of the teeth that presented burst-type progression sites also presented linear-type progression sites, and most of the progressions were of the linear type. Maxillary premolars and anterior teeth tended to show burst-type progression. The parameters identified in this study may guide practitioners in determining the type and extent of treatment needed at the site and patient levels. In addition, these results show that prior hypotheses concerning "burst" and "linear" theories are not valid.
[Mh] Termos MeSH primário: Doenças Periodontais/patologia
[Mh] Termos MeSH secundário: Adulto
Aggregatibacter actinomycetemcomitans/isolamento & purificação
Progressão da Doença
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Doenças Periodontais/microbiologia
Porphyromonas gingivalis/isolamento & purificação
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188670


  3 / 2568 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28435253
[Au] Autor:Miyata S; Miyaji H; Kawasaki H; Yamamoto M; Nishida E; Takita H; Akasaka T; Ushijima N; Iwanaga T; Sugaya T
[Ad] Endereço:Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Kita-ku, Sapporo.
[Ti] Título:Antimicrobial photodynamic activity and cytocompatibility of Au (Capt) clusters photoexcited by blue LED light irradiation.
[So] Source:Int J Nanomedicine;12:2703-2716, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Antimicrobial photodynamic therapy (aPDT) has beneficial effects in dental treatment. We applied captopril-protected gold (Au (Capt) ) clusters as a novel photosensitizer for aPDT. Photoexcited Au clusters under light irradiation generated singlet oxygen ( O ). Accordingly, the antimicrobial and cytotoxic effects of Au (Capt) clusters under dental blue light-emitting diode (LED) irradiation were evaluated. O generation of Au (Capt) clusters under blue LED irradiation (420-460 nm) was detected by a methotrexate (MTX) probe. The antimicrobial effects of photoexcited Au clusters (0, 5, 50, and 500 µg/mL) on oral bacterial cells, such as , and , were assessed by morphological observations and bacterial growth experiments. Cytotoxicity testing of Au clusters and blue LED irradiation was then performed against NIH3T3 and MC3T3-E1 cells. In addition, the biological performance of Au clusters (500 µg/mL) was compared to an organic dye photosensitizer, methylene blue (MB; 10 and 100 µg/mL). We confirmed the O generation ability of Au (Capt) clusters through the fluorescence spectra of oxidized MTX. Successful application of photoexcited Au clusters to aPDT was demonstrated by dose-dependent decreases in the turbidity of oral bacterial cells. Morphological observation revealed that application of Au clusters stimulated destruction of bacterial cell walls and inhibited biofilm formation. Aggregation of Au clusters around bacterial cells was fluorescently observed. However, photoexcited Au clusters did not negatively affect the adhesion, spreading, and proliferation of mammalian cells, particularly at lower doses. In addition, application of Au clusters demonstrated significantly better cytocompatibility compared to MB. We found that a combination of Au (Capt) clusters and blue LED irradiation exhibited good antimicrobial effects through O generation and biosafe characteristics, which is desirable for aPDT in dentistry.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Ouro/farmacologia
Fotoquimioterapia/métodos
Fármacos Fotossensibilizantes/farmacologia
[Mh] Termos MeSH secundário: Aggregatibacter actinomycetemcomitans/efeitos dos fármacos
Animais
Captopril/química
Captopril/farmacologia
Corantes
Ouro/química
Luz
Azul de Metileno/farmacologia
Camundongos
Células NIH 3T3/efeitos dos fármacos
Fármacos Fotossensibilizantes/química
Porphyromonas gingivalis/efeitos dos fármacos
Oxigênio Singlete/metabolismo
Streptococcus mutans/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Coloring Agents); 0 (Photosensitizing Agents); 17778-80-2 (Singlet Oxygen); 7440-57-5 (Gold); 9G64RSX1XD (Captopril); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S131602


  4 / 2568 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28432161
[Au] Autor:Storms I; van den Brand M; Schneeberger P; van 't Hullenaar N
[Ad] Endereço:Canisius Wilhemina Ziekenhuis, Nijmegen, The Netherlands.
[Ti] Título: pneumonia with chest and abdominal wall involvement.
[So] Source:BMJ Case Rep;2017, 2017 Apr 21.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 54-year-old man presented with a productive cough, chest pain, fever and weight loss. Initial analysis revealed a palpable chest wall mass and consolidation in the left lower lobe and pleural abnormalities on imaging. At that point no infectious cause or malignancy was identified. Microbiological analysis of a needle biopsy from a newly developed abdominal wall mass revealed growth of The patient was successfully treated with antibiotic therapy for 1 year. is a Gram-negative coccobacillus and is part of the normal oral flora. It is capable of causing infections in humans including periodontitis, soft tissue abscesses and systemic invasive infections, most commonly endocarditis.
[Mh] Termos MeSH primário: Aggregatibacter actinomycetemcomitans/isolamento & purificação
Infecções por Pasteurellaceae/diagnóstico
Pneumonia Bacteriana/microbiologia
[Mh] Termos MeSH secundário: Parede Abdominal/diagnóstico por imagem
Parede Abdominal/microbiologia
Antibacterianos/uso terapêutico
Seres Humanos
Masculino
Meia-Idade
Infecções por Pasteurellaceae/tratamento farmacológico
Pneumonia Bacteriana/diagnóstico por imagem
Pneumonia Bacteriana/tratamento farmacológico
Tórax/diagnóstico por imagem
Tórax/microbiologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE


  5 / 2568 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28320314
[Au] Autor:Szafranski SP; Deng ZL; Tomasch J; Jarek M; Bhuju S; Rohde M; Sztajer H; Wagner-Döbler I
[Ad] Endereço:Microbial Communication, Helmholtz-Center for Infection Research, Braunschweig, Germany.
[Ti] Título:Quorum sensing of Streptococcus mutans is activated by Aggregatibacter actinomycetemcomitans and by the periodontal microbiome.
[So] Source:BMC Genomics;18(1):238, 2017 03 20.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The oral cavity is inhabited by complex microbial communities forming biofilms that can cause caries and periodontitis. Cell-cell communication might play an important role in modulating the physiologies of individual species, but evidence so far is limited. RESULTS: Here we demonstrate that a pathogen of the oral cavity, Aggregatibacter actinomycetemcomitans (A. act.), triggers expression of the quorum sensing (QS) regulon of Streptococcus mutans, a well-studied model organism for cariogenic streptococci, in dual-species biofilms grown on artificial saliva. The gene for the synthesis of the QS signal XIP is essential for this interaction. Transcriptome sequencing of biofilms revealed that S. mutans up-regulated the complete QS regulon (transformasome and mutacins) in the presence of A. act. and down-regulated oxidative stress related genes. A.act. required the presence of S. mutans for growth. Fimbriae and toxins were its most highly expressed genes and up-regulation of anaerobic metabolism, chaperones and iron acquisition genes was observed in co-culture. Metatranscriptomes from periodontal pockets showed highly variable levels of S. mutans and low levels of A. act.. Transcripts of the alternative sigma-factor SigX, the key regulator of QS in S. mutans, were significantly enriched in periodontal pockets compared to single cultures (log 4.159, FDR ≤0.001, and expression of mutacin related genes and transformasome components could be detected. CONCLUSION: The data show that the complete QS regulon of S. mutans can be induced by an unrelated oral pathogen and S. mutans may be competent in oral biofilms in vivo.
[Mh] Termos MeSH primário: Aggregatibacter actinomycetemcomitans/fisiologia
Interações Microbianas
Microbiota
Periodonto/microbiologia
Percepção de Quorum
Streptococcus mutans/fisiologia
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Biofilmes
Análise por Conglomerados
Perfilação da Expressão Gênica
Regulação Bacteriana da Expressão Gênica
Bolsa Periodontal/microbiologia
Fator sigma/genética
Fator sigma/metabolismo
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Sigma Factor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1186/s12864-017-3618-5


  6 / 2568 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28288638
[Au] Autor:Sharma K; Mudgil P; Whitehall JS; Gosbell I
[Ad] Endereço:Department of Paediatrics, School of Medicine, Western Sydney University, Sydney, NSW, Australia.
[Ti] Título:Aggregatibacter actinomycetemcomitans osteomyelitis in a 12 year old boy: case report emphasizing the importance of tissue culture, and review of literature.
[So] Source:Ann Clin Microbiol Antimicrob;16(1):12, 2017 Mar 14.
[Is] ISSN:1476-0711
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Aggregatibacter actinomycetemcomitans most commonly causes periodontitis but has been reported to infect heart valves, soft tissue, brain and lungs, and distal bones. Osteomyelitis distal to the jaw is rarely described. CASE PRESENTATION: We report an unusual and rare case of chronic osteomyelitis caused by A. actinomycetemcomitans in the toe of a paediatric patient, and review the available literature. The infection was managed with intravenous antibiotics followed by oral antibiotics. CONCLUSION: This is an unusual presentation of A. actinomycetemcomitans causing chronic osteomyelitis presumed due to nidation in a minimally damaged bone, associated with bacteraemia of an oral commensal. It occurred in the toe, without obvious dental predisposition; associated with minimal clinical disturbance and with muted immune response.
[Mh] Termos MeSH primário: Aggregatibacter actinomycetemcomitans/patogenicidade
Antibacterianos/uso terapêutico
Bacteriemia/tratamento farmacológico
Osteomielite/tratamento farmacológico
Osteomielite/microbiologia
Dedos do Pé/microbiologia
[Mh] Termos MeSH secundário: Aggregatibacter actinomycetemcomitans/isolamento & purificação
Amoxicilina/uso terapêutico
Cefotaxima/uso terapêutico
Criança
Seres Humanos
Masculino
Testes de Sensibilidade Microbiana
Dedos do Pé/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 804826J2HU (Amoxicillin); N2GI8B1GK7 (Cefotaxime)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.1186/s12941-017-0186-0


  7 / 2568 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28273301
[Au] Autor:Abbasi J
[Ti] Título:To Prevent Rheumatoid Arthritis, Look Past the Joints to the Gums.
[So] Source:JAMA;317(12):1201-1202, 2017 Mar 28.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aggregatibacter actinomycetemcomitans/metabolismo
Artrite Reumatoide/prevenção & controle
Citrulina/metabolismo
Periodontite/complicações
[Mh] Termos MeSH secundário: Aggregatibacter actinomycetemcomitans/imunologia
Artrite Reumatoide/sangue
Artrite Reumatoide/etiologia
Autoanticorpos/sangue
Cálcio/metabolismo
Citrulina/imunologia
Gengiva/microbiologia
Seres Humanos
Neutrófilos/metabolismo
Periodontite/microbiologia
Proteínas/metabolismo
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Proteins); 29VT07BGDA (Citrulline); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.0764


  8 / 2568 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28270109
[Au] Autor:Silva VO; Pereira LJ; Murata RM
[Ad] Endereço:Herman Ostrow School of Dentistry, Division of Periodontology Diagnostic Sciences, Dental Hygiene & Biomedical Science, University of Southern California, Los Angeles, CA, USA.
[Ti] Título:Oral microbe-host interactions: influence of ß-glucans on gene expression of inflammatory cytokines and metabolome profile.
[So] Source:BMC Microbiol;17(1):53, 2017 Mar 07.
[Is] ISSN:1471-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study was to evaluate the effects of ß-glucan on the expression of inflammatory mediators and metabolomic profile of oral cells [keratinocytes (OBA-9) and fibroblasts (HGF-1) in a dual-chamber model] infected by Aggregatibacter actinomycetemcomitans. The periodontopathogen was applied and allowed to cross the top layer of cells (OBA-9) to reach the bottom layer of cells (HGF-1) and induce the synthesis of immune factors and cytokines in the host cells. ß-glucan (10 µg/mL or 20 µg/mL) were added, and the transcriptional factors and metabolites produced were quantified in the remaining cell layers and supernatant. RESULTS: The relative expression of interleukin (IL)-1-α and IL-18 genes in HGF-1 decreased with 10 µg/mL or 20 µg/mL of ß-glucan, where as the expression of PTGS-2 decreased only with 10 µg/mL. The expression of IL-1-α increased with 20 µg/mL and that of IL-18 increased with 10 µg/mL in OBA-9; the expression of BCL 2, EP 300, and PTGS-2 decreased with the higher dose of ß-glucan. The production of the metabolite 4-aminobutyric acid presented lower concentrations under 20 µg/mL, whereas the concentrations of 2-deoxytetronic acid NIST and oxalic acid decreased at both concentrations used. Acetophenone, benzoic acid, and pinitol presented reduced concentrations only when treated with 10 µg/mL of ß-glucan. CONCLUSIONS: Treatment with ß-glucans positively modulated the immune response and production of metabolites.
[Mh] Termos MeSH primário: Aggregatibacter actinomycetemcomitans/efeitos dos fármacos
Aggregatibacter actinomycetemcomitans/fisiologia
Citocinas/efeitos dos fármacos
Expressão Gênica/efeitos dos fármacos
Interações Hospedeiro-Patógeno
Metaboloma/efeitos dos fármacos
beta-Glucanas/farmacologia
[Mh] Termos MeSH secundário: Acetofenonas/metabolismo
Anti-Infecciosos/farmacologia
Ácido Benzoico/metabolismo
Técnicas de Cultura de Células/métodos
Linhagem Celular
Técnicas de Cocultura
Ciclo-Oxigenase 2/metabolismo
Citocinas/genética
Citocinas/imunologia
Proteína p300 Associada a E1A/metabolismo
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Interações Hospedeiro-Patógeno/imunologia
Seres Humanos
Hidroxibutiratos/metabolismo
Imunomodulação
Inositol/análogos & derivados
Inositol/metabolismo
Interleucina-18/genética
Interleucina-1alfa/genética
Queratinócitos/efeitos dos fármacos
Queratinócitos/metabolismo
Linfoma de Células B/metabolismo
Metaboloma/genética
Metaboloma/imunologia
Boca/imunologia
Boca/microbiologia
Ácido Oxálico/metabolismo
Doenças Periodontais/imunologia
Doenças Periodontais/microbiologia
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
beta-Glucanas/administração & dosagem
beta-Glucanas/metabolismo
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetophenones); 0 (Anti-Infective Agents); 0 (BCL2 protein, human); 0 (Cytokines); 0 (Hydroxybutyrates); 0 (Interleukin-18); 0 (Interleukin-1alpha); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (beta-Glucans); 1518-61-2 (3,4-dihydroxybutanoic acid); 484-68-4 (pinitol); 4L6452S749 (Inositol); 56-12-2 (gamma-Aminobutyric Acid); 8SKN0B0MIM (Benzoic Acid); 9E7R5L6H31 (Oxalic Acid); EC 1.14.99.1 (Cyclooxygenase 2); EC 1.14.99.1 (PTGS2 protein, human); EC 2.3.1.48 (E1A-Associated p300 Protein); EC 2.3.1.48 (EP300 protein, human); RK493WHV10 (acetophenone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1186/s12866-017-0946-1


  9 / 2568 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28247519
[Au] Autor:Nasu K; Fujisawa M; Kato H; Nangaku M
[Ad] Endereço:Division of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo, Japan.
[Ti] Título:Three cases of posterior reversible encephalopathy syndrome with chronic kidney disease triggered by infection.
[So] Source:Nephrology (Carlton);22(4):322-325, 2017 Apr.
[Is] ISSN:1440-1797
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological condition with diverse neurological manifestations. Many clinical factors are known causes of PRES, but only a few cases of PRES have been reported in patients with chronic kidney disease (CKD) and infectious disease. We describe three cases of PRES in patients with CKD triggered by various infectious diseases. Characteristic hyperintense signals on magnetic resonance imaging (MRI) indicating reversible vasogenic brain oedema in various parts of the brain were observed. To explain the pathophysiology of PRES, the hypertension/hyperperfusion and hypoperfusion/vasoconstriction theories have been proposed. Patients with CKD have many complications including uraemia, hypertension, and immunosuppression. Therefore, physicians should recognize that patients with CKD are at high risk of PRES triggered by infectious diseases and promptly diagnose PRES because immediate treatment of the triggers often leads to complete resolution.
[Mh] Termos MeSH primário: Aggregatibacter actinomycetemcomitans/isolamento & purificação
Derivação Arteriovenosa Cirúrgica/efeitos adversos
Endocardite Bacteriana/microbiologia
Infecções por Pasteurellaceae/microbiologia
Síndrome da Leucoencefalopatia Posterior/etiologia
Insuficiência Renal Crônica/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Antibacterianos/uso terapêutico
Endocardite Bacteriana/diagnóstico
Endocardite Bacteriana/terapia
Evolução Fatal
Feminino
Seres Humanos
Angiografia por Ressonância Magnética
Masculino
Meia-Idade
Infecções por Pasteurellaceae/diagnóstico
Infecções por Pasteurellaceae/terapia
Síndrome da Leucoencefalopatia Posterior/diagnóstico por imagem
Síndrome da Leucoencefalopatia Posterior/terapia
Insuficiência Renal Crônica/diagnóstico
Insuficiência Renal Crônica/terapia
Fatores de Risco
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1111/nep.12930


  10 / 2568 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28144851
[Au] Autor:Ganguly A; Ian CK; Sheshala R; Sahu PS; Al-Waeli H; Meka VS
[Ad] Endereço:School of Dentistry, International Medical University, Kuala Lumpur, 57000, Malaysia.
[Ti] Título:Application of diverse natural polymers in the design of oral gels for the treatment of periodontal diseases.
[So] Source:J Mater Sci Mater Med;28(3):39, 2017 Mar.
[Is] ISSN:1573-4838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to prepare periodontal gels using natural polymers such as badam gum, karaya gum and chitosan. These gels were tested for their physical and biochemical properties and assessed for their antibacterial activity against Aggregatibacter actinomycetemcomitans and Streptococcus mutans, two pathogens associated with periodontal disease. Badam gum, karaya gum and chitosan were used to prepare gels of varying concentrations. Moxifloxacin hydrochloride, a known antimicrobial drug was choosen in the present study and it was added to the above gels. The gels were then run through a battery of tests in order to determine their physical properties such as pH and viscosity. Diffusion studies were carried out on the gels containing the drug. Antimicrobial testing of the gels against various bacteria was then carried out to determine the effectiveness of the gels against these pathogens. The results showed that natural polymers can be used to produce gels. These gels do not have inherent antimicrobial properties against A. actinomycetemcomitans and S. mutans. However, they can be used as a transport vehicle to carry and release antimicrobial drugs.
[Mh] Termos MeSH primário: Aggregatibacter actinomycetemcomitans/efeitos dos fármacos
Géis/administração & dosagem
Doenças Periodontais/tratamento farmacológico
Polímeros/administração & dosagem
Streptococcus mutans/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Anti-Infecciosos/química
Produtos Biológicos/uso terapêutico
Quitosana/química
Difusão
Fluoroquinolonas/química
Seres Humanos
Concentração de Íons de Hidrogênio
Goma de Karaya/química
Teste de Materiais
Polímeros/química
Propriedades de Superfície
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Biological Products); 0 (Fluoroquinolones); 0 (Gels); 0 (Polymers); 9000-36-6 (Karaya Gum); 9012-76-4 (Chitosan); U188XYD42P (moxifloxacin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171021
[Lr] Data última revisão:
171021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1007/s10856-017-5852-4



página 1 de 257 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde