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Pesquisa : B03.510.024.049.050.050 [Categoria DeCS]
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[PMID]:28468217
[Au] Autor:Jeong YJ; Suh HW; Shim HS
[Ad] Endereço:Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
[Ti] Título:Cervicofacial Primary Cutaneous Actinomycosis: Surgical Treatment for Complete Remission of the Disease.
[So] Source:J Craniofac Surg;28(3):e269-e271, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Actinomycosis, an infectious bacterial disease caused by Actinomyces species, is very rare and is characterized by contiguous spreading, subacute to chronic granulomatous inflammation and the formation of multiple abscesses and sinus tracts that may discharge sulfur granules. Actinomycosis that presents on the skin without endogenous origin is called primary cutaneous actinomycosis, and the occurrence and treatment of primary cutaneous actinomycosis is rarely reported. This report describes the treatment of primary cervicofacial actinomycosis with a literature review, and emphasizes the importance of surgical option for complete remission of the disease.
[Mh] Termos MeSH primário: Actinomyces/isolamento & purificação
Actinomicose Cervicofacial/cirurgia
Procedimentos Cirúrgicos Dermatológicos/métodos
Dermatopatias Bacterianas/cirurgia
[Mh] Termos MeSH secundário: Actinomicose Cervicofacial/diagnóstico
Actinomicose Cervicofacial/microbiologia
Idoso
Biópsia
Feminino
Seres Humanos
Indução de Remissão
Pele/diagnóstico por imagem
Pele/microbiologia
Dermatopatias Bacterianas/diagnóstico
Dermatopatias Bacterianas/microbiologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003518


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[PMID]:28450600
[Au] Autor:Bennett JW; Eveleigh D; Goodman RM
[Ad] Endereço:School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
[Ti] Título:H. Boyd Woodruff (1917-2017).
[So] Source:Science;356(6336):381, 2017 Apr 28.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antibacterianos/história
Indústria Farmacêutica/história
Microbiologia Industrial/história
[Mh] Termos MeSH secundário: Actinomyces/crescimento & desenvolvimento
Actinomyces/metabolismo
Dactinomicina/metabolismo
História do Século XX
História do Século XXI
Estados Unidos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Woodruff HB
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 1CC1JFE158 (Dactinomycin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1126/science.aan3952


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[PMID]:29173365
[Au] Autor:Coulon A; Kamat R; Jaikishen A; Naljayan M
[Ad] Endereço:School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana. Electronic address: aaron.coulon@gmail.com.
[Ti] Título:Actinomyces Peritonitis: A Unique Therapy.
[So] Source:Am J Med Sci;354(5):521-522, 2017 Nov.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Actinomyces
Actinomicose
Falência Renal Crônica
Peritonite
[Mh] Termos MeSH secundário: Actinomicose/diagnóstico
Actinomicose/tratamento farmacológico
Actinomicose/microbiologia
Adulto
Feminino
Seres Humanos
Falência Renal Crônica/microbiologia
Falência Renal Crônica/terapia
Peritonite/diagnóstico
Peritonite/tratamento farmacológico
Peritonite/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171206
[Lr] Data última revisão:
171206
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28857023
[Au] Autor:Meng X; Wang Y; Lu S; Lai XH; Jin D; Yang J; Xu J
[Ad] Endereço:1​State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206,
[Ti] Título:Actinomyces gaoshouyii sp. nov., isolated from plateau pika (Ochotona curzoniae).
[So] Source:Int J Syst Evol Microbiol;67(9):3363-3368, 2017 Sep.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two strains (pika_113T and pika_114) of a previously undescribed Actinomyces-like bacterium were recovered from the intestinal contents of plateau pika (Ochotona curzoniae) on the Tibet-Qinghai Plateau, China. Results from biochemical characterization indicated that the two strains were phenotypically homogeneous and distinct from other previously described species of the genus Actinomyces. Based on the comparison of 16S rRNA gene sequences and genome analysis, the bacteria were determined to be a hitherto unknown subline within the genus Actinomyces, being most closely related to type strains of Actinomyces denticolens and Actinomyces timonensis with a respective 97.2 and 97.1 % similarity in their 16S rRNA gene sequences. Phylogenetic analyses confirmed that pika_113T was well separated from any other recognized species of the genus Actinomyces and within the cluster with A. denticolens and A. timonensis. The genome of strain pika_113T displayed less than 42 % relatedness in DNA-DNA hybridization with all the available genomes of existing species of the genus Actinomyces in the NCBI database. Collectively, based on the phenotypic characteristics and phylogenetic analyses results, we propose the novel isolates as representatives of Actinomyces gaoshouyii sp. nov. The type strain of Actinomyces gaoshouyii is pika_113T (=CGMCC 4.7372T=DSM 104049T), with a genomic DNA G+C content of 71 mol%.
[Mh] Termos MeSH primário: Actinomyces/classificação
Intestinos/microbiologia
Lagomorpha/microbiologia
Filogenia
[Mh] Termos MeSH secundário: Actinomyces/genética
Actinomyces/isolamento & purificação
Animais
Técnicas de Tipagem Bacteriana
DNA Bacteriano/genética
Hibridização de Ácido Nucleico
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Tibet
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002119


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[PMID]:28721040
[Au] Autor:Zhang H; Komasa S; Mashimo C; Sekino T; Okazaki J
[Ad] Endereço:Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka, Japan.
[Ti] Título:Effect of ultraviolet treatment on bacterial attachment and osteogenic activity to alkali-treated titanium with nanonetwork structures.
[So] Source:Int J Nanomedicine;12:4633-4646, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Alkali-treated titanium with nanonetwork structures (TNS) possesses good osteogenic activity; however, the resistance of this material to bacterial contamination remains inadequate. As such, TNS implants are prone to postoperative infection. In this work, we attempted to alter the biological properties of TNS by treatment with short-duration high-intensity ultraviolet (UV) irradiation. METHODS: TNS discs were treated with UV light (wavelength =254 nm, strength =100 mW/cm ) for 15 minutes using a UV-irradiation machine. We carried out a surface characterization and evaluated the discs for bacterial film formation, protein adsorption, and osteogenic features. RESULTS: The superhydrophilicity and surface hydrocarbon elimination exhibited by the treated material (UV-treated titanium with a nanonetwork structure [UV-TNS]) revealed that this treatment effectively changed the surface characteristics of TNS. Notably, UV-TNS also showed reduced colonization by during an initial attachment period and inhibition of biofilm formation for up to 6 hours. Moreover, compared to conventional TNS, UV-TNS showed superior osteogenic activity as indicated by increased levels of adhesion, proliferation, alkaline phosphatase activity, osteogenic factor production, and osteogenesis-related gene expression by rat bone marrow mesenchymal stem cells (rBMMSCs). This inverse relationship between bacterial attachment and cell adhesion could be due to the presence of electron-hole pairs induced by high-intensity UV treatment. CONCLUSION: We suggest that simple UV treatment has great clinical potential for TNS implants, as it promotes the osseointegration of the TNS while reducing bacterial contamination, and can be conducted chair-side immediately prior to implantation.
[Mh] Termos MeSH primário: Actinomyces/efeitos da radiação
Células Mesenquimais Estromais/efeitos da radiação
Nanoestruturas/química
Titânio/farmacologia
Raios Ultravioleta
[Mh] Termos MeSH secundário: Actinomyces/efeitos dos fármacos
Adsorção
Animais
Aderência Bacteriana/efeitos dos fármacos
Aderência Bacteriana/efeitos da radiação
Adesão Celular/efeitos dos fármacos
Proliferação Celular/efeitos da radiação
Células Mesenquimais Estromais/efeitos dos fármacos
Osseointegração/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
Próteses e Implantes
Ratos Sprague-Dawley
Hidróxido de Sódio/química
Propriedades de Superfície
Titânio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
55X04QC32I (Sodium Hydroxide); D1JT611TNE (Titanium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S136273


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[PMID]:28688759
[Au] Autor:Eschapasse E; Hussenet C; Bergeron A; Lebeaux D
[Ad] Endereço:Service de pneumologie, institut du thorax, hôpital G.-et-R.-Laënnec, CHU de Nantes, 44093 Nantes, France.
[Ti] Título:[Respiratory infections caused by slow-growing bacteria: Nocardia, Actinomyces, Rhodococcus].
[Ti] Título:Infections respiratoires à bactéries à croissance lente : Nocardia, Actinomyces, Rhodococcus..
[So] Source:Rev Mal Respir;34(6):661-671, 2017 Jun.
[Is] ISSN:1776-2588
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: Pneumonia caused by slow-growing bacteria is rare but sometimes severe. STATE OF THE ART: These infections share many similarities such as several differential diagnoses, difficulties to identify the pathogen, the importance of involving the microbiologist in the diagnostic investigation and the need for prolonged antibiotic treatment. However, major differences distinguish them: Nocardia and Rhodococcus infect mainly immunocompromised patients while actinomycosis also concerns immunocompetent patients; the severity of nocardioses is related to their hematogenous spread while locoregional extension by contiguity makes the gravity of actinomycosis. PROSPECTIVE: For these diseases, molecular diagnostic tools are essential, either to obtain a species identification and guide treatment in the case of nocardiosis or to confirm the diagnosis from a biological sample. Treatment of these infections is complex due to: (1) the limited data in the literature; (2) the need for prolonged treatment of several months; (3) the management of toxicities and drug interactions for the treatment of Nocardia and Rhodococcus. CONCLUSION: Close cooperation between pneumonologists, infectious disease specialists and microbiologists is essential for the management of these patients.
[Mh] Termos MeSH primário: Actinomyces
Nocardia
Infecções Respiratórias/microbiologia
Rhodococcus
[Mh] Termos MeSH secundário: Actinomyces/crescimento & desenvolvimento
Actinomyces/isolamento & purificação
Infecções por Actinomycetales/diagnóstico
Infecções por Actinomycetales/microbiologia
Infecções por Actinomycetales/terapia
Actinomicose/diagnóstico
Actinomicose/microbiologia
Actinomicose/terapia
Bactérias/crescimento & desenvolvimento
Bactérias/isolamento & purificação
Diagnóstico Diferencial
Seres Humanos
Hospedeiro Imunocomprometido
Nocardia/crescimento & desenvolvimento
Nocardia/isolamento & purificação
Nocardiose/diagnóstico
Nocardiose/microbiologia
Nocardiose/terapia
Pneumonia/diagnóstico
Pneumonia/microbiologia
Pneumonia/terapia
Infecções Respiratórias/epidemiologia
Infecções Respiratórias/patologia
Infecções Respiratórias/terapia
Rhodococcus/crescimento & desenvolvimento
Rhodococcus/isolamento & purificação
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170710
[St] Status:MEDLINE


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[PMID]:28629509
[Au] Autor:Meng X; Lu S; Wang Y; Lai XH; Wen Y; Jin D; Yang J; Bai X; Zhang G; Pu J; Lan R; Xu J
[Ad] Endereço:1​State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206,
[Ti] Título:Actinomyces vulturis sp. nov., isolated from Gyps himalayensis.
[So] Source:Int J Syst Evol Microbiol;67(6):1720-1726, 2017 06.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two strains of Gram-stain-positive, facultatively anaerobic, non-spore-forming short rods (VUL7T and VUL8) were isolated from rectal swabs of Old World vultures, namely Gyps himalayensis, in Tibet-Qinghai Plateau, China. Optimal growth occurred at 37 °C, pH 6-7, with 1 % (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences classified the two strains to the genus Actinomyces, with highest 16S rRNA gene sequence similarity (95 %) to type strains of Actinomyces haliotis, Actinomyces radicidentis and Actinomyces urogenitalis. The major cellular fatty acids were C18 : 1ω9c and C16 : 0. MK-10(H4) was the major respiratory quinone. The genomic DNA G+C content of the isolate was 54.4 mol%. DNA-DNA hybridization values with the most closely related species ofthe genusActinomyces was 24.6 %. The two strains can be differentiated from the most closely related species such as A. haliotis, A. radicidentis, A. graevenitzii and A. urogenitalis by a list of carbohydrate fermentations and enzyme activities. On the basis of physiological, biochemical and phylogenetic analysis, strains VUL7T and VUL8 represent novel species of the genus Actinomyces, for which the name Actinomyces vulturis sp. nov. is proposed. The type strain is VUL7T (=CGMCC 4.7366T=DSM 103437T).
[Mh] Termos MeSH primário: Actinomyces/classificação
Falconiformes/microbiologia
Filogenia
[Mh] Termos MeSH secundário: Actinomyces/genética
Actinomyces/isolamento & purificação
Animais
Técnicas de Tipagem Bacteriana
Composição de Bases
DNA Bacteriano/genética
Ácidos Graxos/química
Hibridização de Ácido Nucleico
RNA Ribossômico 16S/genética
Reto/microbiologia
Análise de Sequência de DNA
Tibet
Ubiquinona/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S); 1339-63-5 (Ubiquinone); I7T5V2W47R (Ubiquinone Q2)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001851


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[PMID]:28629506
[Au] Autor:Meng X; Lu S; Lai XH; Wang Y; Wen Y; Jin D; Yang J; Xu J
[Ad] Endereço:1​State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206,
[Ti] Título:Actinomyces liubingyangii sp. nov. isolated from the vulture Gypaetus barbatus.
[So] Source:Int J Syst Evol Microbiol;67(6):1873-1879, 2017 Jun.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two strains (VUL4_1T and VUL4_2) of Gram-staining-positive, catalase-negative, non-spore-forming short rods were isolated from rectal swabs of Old World vultures (Gypaetus barbatus) in the Tibet-Qinghai Plateau, China. Analysis of morphological characteristics and biochemical tests indicated that the two strains closely resembled each other but were distinct from other species of the genus Actinomyces previously described. Based on the results of 16S rRNA gene sequence comparison and genome analysis, strains were determined to be members of the genus Actinomyces, closely related to the type strains of Actinomyces marimammalium (96.4 % 16S rRNA gene sequence similarity), Actinomyceshongkongensis (92.4 %), Actinomyceshordeovulneris (92.3 %) and Actinomycesnasicola (92.2 %), respectively. Optimal growth conditions were 37 °C, pH 6-7, with 1 % (w/v) NaCl. Strain VUL4_1T contained C18 : 1ω9c and C16 : 0 as the major cellular fatty acids and diphosphatidylglycerol as the major component of the polar lipids. The genomic DNA G+C content of VUL4_1T was 54.9 mol%. Strain VUL4_1T showed less than 70 % DNA-DNA relatedness with other species of the genus Actinomyces, further supporting strain VUL4_1T as a representative of a novel species. Based on the phenotypic data and phylogenetic inference, a novel species, Actinomyces liubingyangii sp. nov., is proposed with VUL4_1T (=CGMCC 4.7370T=DSM 104050T) as the type strain.
[Mh] Termos MeSH primário: Falconiformes/microbiologia
Filogenia
Reto/microbiologia
[Mh] Termos MeSH secundário: Actinomyces/genética
Actinomyces/isolamento & purificação
Animais
Técnicas de Tipagem Bacteriana
DNA Bacteriano/genética
Ácidos Graxos/química
Hibridização de Ácido Nucleico
Fosfolipídeos/química
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Compostos de Espiro
Tibet
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BAS 100); 0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 0 (Spiro Compounds)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001884


  9 / 3736 MEDLINE  
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[PMID]:28590243
[Au] Autor:García-García A; Coronel-Martínez J; Leon DC; Romero-Figueroa MDS; Caballero-Pantoja YE; Manzanares-Leal GL; Rodriguez-Morales M; Sandoval-Trujillo H; Ramírez-Durán N
[Ad] Endereço:1​Laboratory of Medical and Environmental Microbiology, Department of Medicine, Autonomous University of the State of Mexico, Toluca 50180, Mexico.
[Ti] Título:Detection of Actinomyces spp. in cervical exudates from women with cervical intraepithelial neoplasia or cervical cancer.
[So] Source:J Med Microbiol;66(6):706-712, 2017 Jun.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Under certain circumstances, Actinomyces behaves as an opportunistic microorganism and can cause actinomycosis, a chronic and inflammatory granulomatous infection. The purpose of this project was to detect the presence of Actinomyces in cervical exudates from women with cervical intraepithelial neoplasia (CIN) and women with cervical cancer. METHODOLOGY: Cervical samples from 92 women were divided into three groups: CIN, cervical cancer and healthy women. Metagenomic DNA extraction was performed following the Qiagen QIAamp Mini Kit protocol. A specific fragment (675 bp) was amplified by PCR in order to detect the presence of Actinomycetales. Samples in which Actinomycetales was detected were subjected to separate amplification reactions with primer pairs for A. israelii, A. viscosus, A. meyeri and A. odontolyticus. Amplified products were observed by 2 % agarose gel electrophoresis. RESULTS: Actinomyces were found in 10 % of women with CIN, 36.6 % of women with cervical cancer and 9 % of healthy women. The species identified in this study were A. meyeri in 14/92 samples (15.2 %), A. viscosus in 10/92 samples (10.8 %), A. odontolyticus in 4/92 samples (4.3 %) and A. israelii in 6/92 samples (6.5 %). CONCLUSION: Patients with cervical cancer had a higher prevalence of the presence of Actinomyces compared to the CIN and control groups. This is the first study in which a deliberate search of this genus has been performed in women with cervical pathologies. The use of specific primers for each species facilitated their detection in comparison with traditional isolation methods. More information is necessary to understand the molecular mechanisms involved in the complex role that bacterial communities may play in the development of cancer (and vice versa).
[Mh] Termos MeSH primário: Actinomyces/isolamento & purificação
Neoplasia Intraepitelial Cervical/microbiologia
Colo do Útero/microbiologia
Neoplasias do Colo do Útero/microbiologia
[Mh] Termos MeSH secundário: Actinomyces/classificação
Actinomyces/genética
Actinomicose/microbiologia
Adulto
Colo do Útero/patologia
Estudos Transversais
Feminino
Genótipo
Voluntários Saudáveis
Seres Humanos
Metagenômica
Meia-Idade
Reação em Cadeia da Polimerase
Prevalência
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000485


  10 / 3736 MEDLINE  
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[PMID]:28442411
[Au] Autor:El-Nekeety AA; Salman AS; Hathout AS; Sabry BA; Abdel-Aziem SH; Hassan NS; Abdel-Wahhab MA
[Ad] Endereço:Food Toxicology & Contaminants Department, National Research Center, Dokki, Cairo, Egypt.
[Ti] Título:Evaluation of the bioactive extract of actinomyces isolated from the Egyptian environment against aflatoxin B -induce cytotoxicity, genotoxicity and oxidative stress in the liver of rats.
[So] Source:Food Chem Toxicol;105:241-255, 2017 Jul.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to determine the bioactive compounds of actinomyces (ACT) isolated from the Egyptian environment (D-EGY) and to evaluate their protective activity against AFB in female Sprague-Dawley rats. Six groups of animals were treated orally for 3 weeks included: C, the control group, T1, AFB -treated group (80 µg/kg b.w), T2 and T3, the groups received ACT extract at low (25 mg/kg b.w) or high (50 mg/kg b.w) doses, T4 and T5, the groups received AFB plus the low or high dose of ACT extract. Blood, bone marrow and tissue samples were collected for different analyses and histological examination. The results revealed the identification of 40 components, representing 99.98%. Treatment with AFB disturbs liver function parameters, oxidative stress markers, antioxidant gene expressions, DNA fragmentation and induced severe histological changes. ACT extract at the low or high doses did not induce significant changes in all the tested parameters or histological picture of the liver. Moreover, ACT extract succeeded to induce a significant protection against the toxicity of AFB . It could be concluded that the bioactive compounds in ACT are promise candidate for the development of food additive or drugs for the protection and treatment of liver disorders in the endemic area.
[Mh] Termos MeSH primário: Actinomyces/química
Aflatoxina B1/toxicidade
Fatores Biológicos/farmacologia
Dano ao DNA/efeitos dos fármacos
Fígado/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Microbiologia do Solo
[Mh] Termos MeSH secundário: Actinomyces/genética
Actinomyces/isolamento & purificação
Actinomyces/metabolismo
Aflatoxina B1/metabolismo
Animais
Fatores Biológicos/isolamento & purificação
Fatores Biológicos/metabolismo
Fragmentação do DNA/efeitos dos fármacos
Egito
Feminino
Fígado/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Factors); 9N2N2Y55MH (Aflatoxin B1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE



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