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[PMID]: 28741682 [Au] Autor: Rajamani Sekar SK; Veeraraghavan B; Anandan S; Devanga Ragupathi NK; Sangal L; Joshi S [Ad] Endereço: Department of Clinical Microbiology, Christian Medical College, Vellore, India. [Ti] Título: Strengthening the laboratory diagnosis of pathogenic Corynebacterium species in the Vaccine era. [So] Source: Lett Appl Microbiol;65(5):354-365, 2017 Nov. [Is] ISSN: 1472-765X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Over the last three decades, successful implementation of the diphtheria vaccination in the developed and developing countries has reduced the infections caused by the toxigenic strains of Corynebacterium diphtheriae, but a concomitant increase in the invasive infections due to the nontoxigenic strains was seen. In addition, the recent reports on the emergence of nontoxigenic toxin gene-bearing strains, having the potential to revert back to toxigenic form poses a significant threat to human beings. Besides infections caused by C. diphtheriae, the emergence of the respiratory, cutaneous and invasive infections by related pathogenic Corynebacterium species like C. ulcerans and C. pseudotuberculosis, complicate the diagnosis and management of infection. These observations together with the widespread prevalence of diphtheria in the vaccine era, necessitates the strengthening of the epidemiological surveillance and laboratory diagnosis of the pathogen. This review provides the overview of the advantages and limitations of different molecular methods and the role of MALDI-TOF in the laboratory diagnosis of Diphtheria. The contribution of next generation sequencing technology and different genotyping techniques in understanding the pathogenicity, transmission dynamics and epidemiology of the C. diphtheriae is discussed. [Mh] Termos MeSH primário: Vacinas Bacterianas/isolamento & purificação Infecções por Corynebacterium/diagnóstico Corynebacterium/isolamento & purificação [Mh] Termos MeSH secundário: Vacinas Bacterianas/genética Técnicas de Laboratório Clínico Corynebacterium/genética Infecções por Corynebacterium/microbiologia Genótipo Sequenciamento de Nucleotídeos em Larga Escala Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Bacterial Vaccines) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180219 [Lr] Data última revisão: 180219 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170726 [St] Status: MEDLINE [do] DOI: 10.1111/lam.12781

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[PMID]: 29364605 [Au] Autor: Skladnev DA; Mulyukin AL; Filippoval SN; Kulikov EE; Letaroval MA; Yuzbasheva EA; Karnysheva EA; Brushkov AV; Gal'chenko VF [Ti] Título: [Modeling the Propagation of Microbial Cells and Phage Particles from the Sites of Permafrost Thawing.] [So] Source: Mikrobiologiia;85(5):580-587, 2016 Sep. [Is] ISSN: 0026-3656 [Cp] País de publicação: Russia (Federation) [La] Idioma: rus [Ab] Resumo: A method is proposed for integral assessment of the propagation of microbial cells and viral parti- cles during seasonal thawing of relic ice wedge layers. The results of on-site and laboratory investigation car- ried out in the upper part of permafrost exposure at Mamontova Gora (Yakutiya, Russia) are presented. To increase reliability of the results, suspensions of two microbial species and two coliphage species were intro- duced as biomarkers directly on the surface of thaing ice and in the meltwater flow. Each of the four different model biological objects was shown to possess unique parameters of movement in the meltwater flow and is able to move 132 m in 25-35 min with the water flow. [Mh] Termos MeSH primário: Colífagos/fisiologia Corynebacterium/fisiologia Movimento/fisiologia Pergelissolo/microbiologia Rios/microbiologia Yarrowia/fisiologia [Mh] Termos MeSH secundário: Gelo/análise Modelos Biológicos Organismos Geneticamente Modificados Transição de Fase Reologia/métodos Estações do Ano Sibéria [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ice) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180208 [Lr] Data última revisão: 180208 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180125 [St] Status: MEDLINE

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[PMID]: 29258359 [Au] Autor: Sebastián M; Anoz-Carbonell E; Gracia B; Cossio P; Aínsa JA; Lans I; Medina M [Ad] Endereço: a Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias , Universidad de Zaragoza , Zaragoza , Spain. [Ti] Título: Discovery of antimicrobial compounds targeting bacterial type FAD synthetases. [So] Source: J Enzyme Inhib Med Chem;33(1):241-254, 2018 Dec. [Is] ISSN: 1475-6374 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The increase of bacterial strains resistant to most of the available antibiotics shows a need to explore novel antibacterial targets to discover antimicrobial drugs. Bifunctional bacterial FAD synthetases (FADSs) synthesise the flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These cofactors act in vital processes as part of flavoproteins, making FADS an essential enzyme. Bacterial FADSs are potential antibacterial targets because of differences to mammalian enzymes, particularly at the FAD producing site. We have optimised an activity-based high throughput screening assay targeting Corynebacterium ammoniagenes FADS (CaFADS) that identifies inhibitors of its different activities. We selected the three best high-performing inhibitors of the FMN:adenylyltransferase activity (FMNAT) and studied their inhibition mechanisms and binding properties. The specificity of the CaFADS hits was evaluated by studying also their effect on the Streptococcus pneumoniae FADS activities, envisaging differences that can be used to discover species-specific antibacterial drugs. The antimicrobial effect of these compounds was also evaluated on C. ammoniagenes, S. pneumoniae, and Mycobacterium tuberculosis cultures, finding hits with favourable antimicrobial properties. [Mh] Termos MeSH primário: Antibacterianos/farmacologia Corynebacterium/enzimologia Descoberta de Drogas Inibidores Enzimáticos/farmacologia Nucleotidiltransferases/antagonistas & inibidores [Mh] Termos MeSH secundário: Antibacterianos/síntese química Antibacterianos/química Corynebacterium/efeitos dos fármacos Relação Dose-Resposta a Droga Inibidores Enzimáticos/síntese química Inibidores Enzimáticos/química Testes de Sensibilidade Microbiana Simulação de Acoplamento Molecular Estrutura Molecular Mycobacterium tuberculosis/efeitos dos fármacos Nucleotidiltransferases/metabolismo Streptococcus pneumoniae/efeitos dos fármacos Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Enzyme Inhibitors); EC 2.7.7.- (Nucleotidyltransferases); EC 2.7.7.2 (FMN adenylyltransferase) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171229 [Lr] Data última revisão: 171229 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171221 [St] Status: MEDLINE [do] DOI: 10.1080/14756366.2017.1411910

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[PMID]: 29216202 [Au] Autor: Hang J; Zavaljevski N; Yang Y; Desai V; Ruck RC; Macareo LR; Jarman RG; Reifman J; Kuschner RA; Keiser PB [Ad] Endereço: Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America. [Ti] Título: Composition and variation of respiratory microbiota in healthy military personnel. [So] Source: PLoS One;12(12):e0188461, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Certain occupational and geographical exposures have been associated with an increased risk of lung disease. As a baseline for future studies, we sought to characterize the upper respiratory microbiomes of healthy military personnel in a garrison environment. Nasal, oropharyngeal, and nasopharyngeal swabs were collected from 50 healthy active duty volunteers eight times over the course of one year (1107 swabs, completion rate = 92.25%) and subjected to pyrosequencing of the V1-V3 region of 16S rDNA. Respiratory bacterial taxa were characterized at the genus level, using QIIME 1.8 and the Ribosomal Database Project classifier. High levels of Staphylococcus, Corynebacterium, and Propionibacterium were observed among both nasal and nasopharyngeal microbiota, comprising more than 75% of all operational taxonomical units (OTUs). In contrast, Streptococcus was the sole dominant bacterial genus (approximately 50% of all OTUs) in the oropharynx. The average bacterial diversity was greater in the oropharynx than in the nasal or nasopharyngeal region at all time points. Diversity analysis indicated a significant overlap between nasal and nasopharyngeal samples, whereas oropharyngeal samples formed a cluster distinct from these two regions. The study produced a large set of pyrosequencing data on the V1-V3 region of bacterial 16S rDNA for the respiratory microbiomes of healthy active duty Service Members. Pre-processing of sequencing reads showed good data quality. The derived microbiome profiles were consistent both internally and with previous reports, suggesting their utility for further analyses and association studies based on sequence and demographic data. [Mh] Termos MeSH primário: Microbiota Militares Sistema Respiratório/microbiologia [Mh] Termos MeSH secundário: Corynebacterium/genética Corynebacterium/isolamento & purificação DNA Ribossômico/genética Feminino Seres Humanos Masculino Cavidade Nasal/microbiologia Nasofaringe/microbiologia Propionibacterium/genética Propionibacterium/isolamento & purificação RNA Ribossômico 16S/genética Staphylococcus/genética Staphylococcus/isolamento & purificação [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (DNA, Ribosomal); 0 (RNA, Ribosomal, 16S) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171229 [Lr] Data última revisão: 171229 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171208 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0188461

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[PMID]: 29046006 [Au] Autor: Jenssen C; Schwede I; Neumann V; Pietsch C; Handrick W [Ad] Endereço: Krankenhaus Märkisch Oderland, Akademisches Lehrkrankenhaus der Medizinischen Hochschule Brandenburg "Theodor Fontane", Klinik für Innere Medizin, Strausberg. [Ti] Título: [Skin and Soft Tissue Infections Due to Corynebacterium ulcerans - Case Reports]. [Ti] Título: Haut- und Weichteilinfektionen durch Corynebacterium ulcerans ­ Fallberichte.. [So] Source: Dtsch Med Wochenschr;142(21):1609-1612, 2017 Oct. [Is] ISSN: 1439-4413 [Cp] País de publicação: Germany [La] Idioma: ger [Ab] Resumo: We report on three patients suffering from skin and soft tissue infections of the legs due to toxigenic Corynebacterium ulcerans strains. In all three patients, there was a predisposition due to chronic diseases. Three patients had domestic animals (cat, dog) in their households. A mixed bacterial flora including Corynebacterium ulcerans was found in wound swab samples. Diphtheric toxin was produced by the Corynebacterium ulcerans strains in all three cases. In all three patients, successful handling of the skin and soft tissue infections was possible by combining local treatment with antibiotics. Diphtheria antitoxin was not administered in any case. Based on a review of the recent literature pathogenesis, clinical symptoms and signs, diagnostics and therapy of skin and soft tissue infections due to Corynebacterium ulcerans are discussed. Corynebacterium ulcerans should be considered as a potential cause of severe skin and soft tissue infections. Occupational or domestic animal contacts should be evaluated. [Mh] Termos MeSH primário: Infecções por Corynebacterium/microbiologia Dermatopatias Bacterianas/microbiologia Infecções dos Tecidos Moles/microbiologia [Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais Animais Animais Domésticos Toxinas Bacterianas/biossíntese Corynebacterium/classificação Corynebacterium/metabolismo Infecções por Corynebacterium/complicações Infecções por Corynebacterium/diagnóstico Infecções por Corynebacterium/terapia Feminino Seres Humanos Masculino Meia-Idade Dermatopatias Bacterianas/complicações Dermatopatias Bacterianas/diagnóstico Dermatopatias Bacterianas/terapia Infecções dos Tecidos Moles/complicações Infecções dos Tecidos Moles/diagnóstico Infecções dos Tecidos Moles/terapia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Bacterial Toxins) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171027 [Lr] Data última revisão: 171027 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171019 [St] Status: MEDLINE [do] DOI: 10.1055/s-0043-117929

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[PMID]: 28850578 [Au] Autor: Shukla SK; Ye Z; Sandberg S; Reyes I; Fritsche TR; Keifer M [Ad] Endereço: Molecular Microbiology Laboratory, Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, Wisconsin, United States of America. [Ti] Título: The nasal microbiota of dairy farmers is more complex than oral microbiota, reflects occupational exposure, and provides competition for staphylococci. [So] Source: PLoS One;12(8):e0183898, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Allergic and autoimmune diseases had been attributed to lack of exposure to biodiversity, an important factor in regulating immune homeostasis in a healthy host. We posit that the microbiome of healthy dairy farmers (DF) will be richer than non-farmers (NF) living in urban settings due to exposure to a greater biodiversity in the dairy environment. However, no studies have investigated the relationships between microbiota of dairy farmers (DF) compared with urban non-farmers (NF). We compared the nasal and oral microbiota of dairy farmers (N_DF, O_DF, respectively) with nasal and oral microbiota of NF in the same geographical area. The N_DF showed high microbial diversity with hundreds of unique genera that reflected environmental/occupational exposures. The nasal and oral microbiomes clustered separately from each other using Principal Coordinate Analysis, and with DF harboring two-fold and 1.5-fold greater exclusive genera in their nose and mouth respectively, than did non-farmers. Additionally, the N_DF group had a lower burden of Staphylococcus spp. suggesting a correlation between higher microbial diversity and competition for colonization by staphylococci. The N_DF samples were negative for the mecA gene, a marker of methicillin-resistance in staphylococci. The lower burden of staphylococci was found to be independent of the abundance of Corynebacterium spp. Exposure to greater biodiversity could enhance microbial competition, thereby reducing colonization with opportunistic pathogens. Future studies will analyze whether exposure to livestock microbiomes offers protection from acute and chronic diseases. [Mh] Termos MeSH primário: Fazendeiros Microbiota/fisiologia Boca/microbiologia Cavidade Nasal/microbiologia Exposição Ocupacional [Mh] Termos MeSH secundário: Adulto Corynebacterium/isolamento & purificação Seres Humanos Meia-Idade Staphylococcus/isolamento & purificação Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171019 [Lr] Data última revisão: 171019 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170830 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0183898

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[PMID]: 28845933 [Au] Autor: Kogan MI; Naboka YL; Bedzhanyan SK; Mitusova EV; Gudima IA; Morgun PP; Vasileva LI [Ad] Endereço: RostSMU of Minzdrav of Russia, Rostov on Don, Russia. [Ti] Título: [Is bacteriological testing of bladder urine informative in acute obstructive pyelo- nephritis?] [So] Source: Urologiia;(3):10-15, 2017 Jul. [Is] ISSN: 1728-2985 [Cp] País de publicação: Russia (Federation) [La] Idioma: rus [Ab] Resumo: The problem of the etiology and pathogenesis of acute obstructive pyelonephritis (OOP) remains one of the challenging issues of modern urology. Etiological agents of pyelonephritis can be both gram-negative and gram-positive opportunistic bacteria mostly belonging to the normal flora in humans. The generally accepted diagnostic work-up involves a bacteriological testing of not pelvic urine, but of bladder urine collected by a transurethral catheter or midstream specimens of urine collected from the patients. The aim of our study was to compare the microbiota of bladder and pelvic urine in patients with OOP. MATERIALS AND METHODS: The study comprised 72 sequentially selected patients (12 men and 60 women) with OOP associated with ureteral stones. Mean age of patients was 53.7+/-0.5 years. All patients underwent bacteriological examination of the bladder urine collected by a transurethral catheter and pelvic urine obtained after relieving stone-related ureteral obstruction. Urinary diversion was performed using j-j stent and PCN in 64 and 8 patients, respectively. Preoperative prophylactic antibiotics were administered routinely. Bacteriological testing of urine was carried out using an extended set (9-10) of culture media. Empirical antibiotic therapy was initiated only after the restoration of urine outflow from the kidney and continued for 5-6 days until the availability of bacteriological testing results. RESULTS: Levels of bacteriuria with Enterobacteria, gram-positive pathogens and NAB in two urine samples did not differ significantly (p>0.05). There was a wide range of bacteriuria from 101 to 106 CFU/ml of most microorganisms except @Proteus spp., S. aureus. In bladder urine, the rates of bacteriuria of more or equal 104 CFU/ml for E. coli, Klebsiella spp. and Proteus spp. were 90.9%, 72.7% and 100.0%, respectively. For the remaining microorganisms, predominant bacteriuria was less or equal 103 CFU/ml. In pelvic urine, the rates of bacteriuria of more or equal 104 CFU/ml for E. coli, Klebsiella spp. and Proteus spp. was 71.8%, 40.0% and 66.7%, respectively. Other uropathogens in the pelvic urine mainly had a bacterial count of less or equal 103 CFU/ml. Only the concentration of Corynebacterium spp. in the pelvic urine significantly (p=0.023) differed from that of the bladder urine. There were no significant differences between microbiota of bladder and pelvic urine depending on duration of OOP except higher rates of Corynebacterium spp. in the bladder urine. [Mh] Termos MeSH primário: Pielonefrite/urina Infecções Urinárias/urina Urina/microbiologia [Mh] Termos MeSH secundário: Adulto Idoso Antibacterianos/administração & dosagem Bacteriúria/prevenção & controle Bacteriúria/urina Corynebacterium/isolamento & purificação Escherichia coli/isolamento & purificação Feminino Seres Humanos Klebsiella/isolamento & purificação Masculino Meia-Idade Proteus/isolamento & purificação Pielonefrite/prevenção & controle Infecções Urinárias/prevenção & controle Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171109 [Lr] Data última revisão: 171109 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170829 [St] Status: MEDLINE

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[PMID]: 28709803 [Au] Autor: St Leger AJ; Desai JV; Drummond RA; Kugadas A; Almaghrabi F; Silver P; Raychaudhuri K; Gadjeva M; Iwakura Y; Lionakis MS; Caspi RR [Ad] Endereço: Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA. [Ti] Título: An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells. [So] Source: Immunity;47(1):148-158.e5, 2017 Jul 18. [Is] ISSN: 1097-4180 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Mucosal sites such as the intestine, oral cavity, nasopharynx, and vagina all have associated commensal flora. The surface of the eye is also a mucosal site, but proof of a living, resident ocular microbiome remains elusive. Here, we used a mouse model of ocular surface disease to reveal that commensals were present in the ocular mucosa and had functional immunological consequences. We isolated one such candidate commensal, Corynebacterium mastitidis, and showed that this organism elicited a commensal-specific interleukin-17 response from γδ T cells in the ocular mucosa that was central to local immunity. The commensal-specific response drove neutrophil recruitment and the release of antimicrobials into the tears and protected the eye from pathogenic Candida albicans or Pseudomonas aeruginosa infection. Our findings provide direct evidence that a resident commensal microbiome exists on the ocular surface and identify the cellular mechanisms underlying its effects on ocular immune homeostasis and host defense. [Mh] Termos MeSH primário: Candida albicans/imunologia Candidíase/imunologia Córnea/imunologia Infecções por Corynebacterium/imunologia Corynebacterium/imunologia Infecções Oculares/imunologia Imunidade nas Mucosas Interleucina-17/metabolismo Microbiota/imunologia Neutrófilos/imunologia Infecções por Pseudomonas/imunologia Pseudomonas aeruginosa/imunologia Linfócitos T/imunologia Lágrimas/imunologia [Mh] Termos MeSH secundário: Animais Candidíase/microbiologia Córnea/microbiologia Infecções por Corynebacterium/microbiologia Modelos Animais de Doenças Infecções Oculares/microbiologia Interações Hospedeiro-Patógeno Seres Humanos Interleucina-17/genética Camundongos Camundongos Endogâmicos C57BL Camundongos Knockout Infiltração de Neutrófilos Neutrófilos/microbiologia Infecções por Pseudomonas/microbiologia Receptores de Antígenos de Linfócitos T gama-delta/genética Receptores de Antígenos de Linfócitos T gama-delta/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Interleukin-17); 0 (Receptors, Antigen, T-Cell, gamma-delta) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170925 [Lr] Data última revisão: 170925 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170716 [St] Status: MEDLINE

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[PMID]: 28700747 [Au] Autor: Borgdorff H; van der Veer C; van Houdt R; Alberts CJ; de Vries HJ; Bruisten SM; Snijder MB; Prins M; Geerlings SE; Schim van der Loeff MF; van de Wijgert JHHM [Ad] Endereço: Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands. [Ti] Título: The association between ethnicity and vaginal microbiota composition in Amsterdam, the Netherlands. [So] Source: PLoS One;12(7):e0181135, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To evaluate whether ethnicity is independently associated with vaginal microbiota (VMB) composition in women living in Amsterdam, the Netherlands, as has been shown for American women. METHODS: Women (18-34 years, non-pregnant, N = 610) representing the six largest ethnic groups (Dutch, African Surinamese, South-Asian Surinamese, Turkish, Moroccan, and Ghanaian) were sampled from the population-based HELIUS study. Sampling was performed irrespective of health status or healthcare seeking behavior. DNA was extracted from self-sampled vaginal swabs and sequenced by Illumina MiSeq (16S rRNA gene V3-V4 region). RESULTS: The overall prevalence of VMBs not dominated by lactobacilli was 38.5%: 32.2% had a VMB resembling bacterial vaginosis and another 6.2% had a VMB dominated by Bifidobacteriaceae (not including Gardnerella vaginalis), Corynebacterium, or pathobionts (streptococci, staphylococci, Proteus or Enterobacteriaceae). The most prevalent VMB in ethnically Dutch women was a Lactobacillus crispatus-dominated VMB, in African Surinamese and Ghanaian women a polybacterial G. vaginalis-containing VMB, and in the other ethnic groups a L. iners-dominated VMB. After adjustment for sociodemographic, behavioral and clinical factors, African Surinamese ethnicity (adjusted odds ratio (aOR) 5.1, 95% confidence interval (CI) 2.1-12.0) and Ghanaian ethnicity (aOR 4.8, 95% CI 1.8-12.6) were associated with having a polybacterial G. vaginalis-containing VMB, and African Surinamese ethnicity with a L. iners-dominated VMB (aOR 2.8, 95% CI 1.2-6.2). Shorter steady relationship duration, inconsistent condom use with casual partners, and not using hormonal contraception were also associated with having a polybacterial G. vaginalis-containing VMB, but human papillomavirus infection was not. Other sexually transmitted infections were uncommon. CONCLUSIONS: The overall prevalence of having a VMB not dominated by lactobacilli in this population-based cohort of women aged 18-34 years in Amsterdam was high (38.5%), and women of sub-Saharan African descent were significantly more likely to have a polybacterial G. vaginalis-containing VMB than Dutch women independent of modifiable behaviors. [Mh] Termos MeSH primário: Microbiota/fisiologia Vagina/microbiologia [Mh] Termos MeSH secundário: Adolescente Adulto Bifidobacterium/genética Bifidobacterium/fisiologia Corynebacterium/genética Corynebacterium/fisiologia Enterobacteriaceae/genética Enterobacteriaceae/fisiologia Feminino Seres Humanos Lactobacillus/genética Lactobacillus/fisiologia Microbiota/genética Países Baixos Proteus/genética Proteus/fisiologia RNA Ribossômico 16S/genética Staphylococcus/genética Staphylococcus/fisiologia Streptococcus/genética Streptococcus/fisiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (RNA, Ribosomal, 16S) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170925 [Lr] Data última revisão: 170925 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170713 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0181135

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[PMID]: 28549450 [Au] Autor: Xu J; Yang Q; Li J; Zheng X [Ad] Endereço: Intensive Care Unit, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, People's Republic of China. [Ti] Título: The left atrial bacterial vegetative mass due to Corynebacterium striatum as a presentation of myxoma: a case report. [So] Source: BMC Infect Dis;17(1):368, 2017 May 26. [Is] ISSN: 1471-2334 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Corynebacterium striatum is a member of the non-diphtherial corynebacteria, which are ubiquitous in nature and generally colonize the skin and mucous membranes of humans. Rarely, it causes infective endocarditis (IE). We report a case of rare left atrial bacterial vegetative mass due to C. striatum masquerading as a myxoma identified through a tortuous diagnostic process, and present a brief review of the relevant literature. CASE PRESENTATION: We present a case of 63-year-old man who presented with progressively worsening dyspnea on exertion and lower leg edema, and was diagnosed with heart failure. Transesophageal echocardiography (TEE) revealed that the left atrium was filled with a 2.7 cm × 2.6 cm mass. The patient, who had no signs of infection or related risk factors, was suspected of having a left atrial myxoma clinically. After excising the mass, the histopathology suggested thrombus with no myxocytes. Postoperatively, a fever appeared and C. striatum was isolated from the blood cultures. Although antibiotics were used, the symptoms of heart failure worsened gradually and echocardiography revealed valve vegetation. The patient underwent a second operation because of IE. Surprisingly, the mass was confirmed to be a bacterial vegetation due to C. striatum based on Gram staining at a 1000× magnification, although this was not noted on routine pathological examination of the two surgical specimens. CONCLUSIONS: Physicians should be aware of Corynebacterium in blood cultures, which cannot simply be assumed to be a contaminant. A diagnosis of IE should be suspected, particularly in high-risk patients or those with an unexplained fever. Our patient had IE due to C. striatum with no risk factors. This case supports the diagnosis of IE using a combination of pathology and etiology. [Mh] Termos MeSH primário: Infecções por Corynebacterium/diagnóstico Endocardite Bacteriana/diagnóstico Átrios do Coração/microbiologia [Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico Corynebacterium/patogenicidade Infecções por Corynebacterium/tratamento farmacológico Infecções por Corynebacterium/cirurgia Diagnóstico Diferencial Ecocardiografia Endocardite/diagnóstico Endocardite Bacteriana/tratamento farmacológico Endocardite Bacteriana/cirurgia Átrios do Coração/patologia Insuficiência Cardíaca/diagnóstico Neoplasias Cardíacas/diagnóstico Seres Humanos Masculino Meia-Idade Mixoma/diagnóstico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170818 [Lr] Data última revisão: 170818 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170528 [St] Status: MEDLINE [do] DOI: 10.1186/s12879-017-2468-8

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