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[PMID]: | 28700747 |
[Au] Autor: | Borgdorff H; van der Veer C; van Houdt R; Alberts CJ; de Vries HJ; Bruisten SM; Snijder MB; Prins M; Geerlings SE; Schim van der Loeff MF; van de Wijgert JHHM |
[Ad] Endereço: | Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands. |
[Ti] Título: | The association between ethnicity and vaginal microbiota composition in Amsterdam, the Netherlands. |
[So] Source: | PLoS One;12(7):e0181135, 2017. | [Is] ISSN: | 1932-6203 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | OBJECTIVE: To evaluate whether ethnicity is independently associated with vaginal microbiota (VMB) composition in women living in Amsterdam, the Netherlands, as has been shown for American women. METHODS: Women (18-34 years, non-pregnant, N = 610) representing the six largest ethnic groups (Dutch, African Surinamese, South-Asian Surinamese, Turkish, Moroccan, and Ghanaian) were sampled from the population-based HELIUS study. Sampling was performed irrespective of health status or healthcare seeking behavior. DNA was extracted from self-sampled vaginal swabs and sequenced by Illumina MiSeq (16S rRNA gene V3-V4 region). RESULTS: The overall prevalence of VMBs not dominated by lactobacilli was 38.5%: 32.2% had a VMB resembling bacterial vaginosis and another 6.2% had a VMB dominated by Bifidobacteriaceae (not including Gardnerella vaginalis), Corynebacterium, or pathobionts (streptococci, staphylococci, Proteus or Enterobacteriaceae). The most prevalent VMB in ethnically Dutch women was a Lactobacillus crispatus-dominated VMB, in African Surinamese and Ghanaian women a polybacterial G. vaginalis-containing VMB, and in the other ethnic groups a L. iners-dominated VMB. After adjustment for sociodemographic, behavioral and clinical factors, African Surinamese ethnicity (adjusted odds ratio (aOR) 5.1, 95% confidence interval (CI) 2.1-12.0) and Ghanaian ethnicity (aOR 4.8, 95% CI 1.8-12.6) were associated with having a polybacterial G. vaginalis-containing VMB, and African Surinamese ethnicity with a L. iners-dominated VMB (aOR 2.8, 95% CI 1.2-6.2). Shorter steady relationship duration, inconsistent condom use with casual partners, and not using hormonal contraception were also associated with having a polybacterial G. vaginalis-containing VMB, but human papillomavirus infection was not. Other sexually transmitted infections were uncommon. CONCLUSIONS: The overall prevalence of having a VMB not dominated by lactobacilli in this population-based cohort of women aged 18-34 years in Amsterdam was high (38.5%), and women of sub-Saharan African descent were significantly more likely to have a polybacterial G. vaginalis-containing VMB than Dutch women independent of modifiable behaviors. |
[Mh] Termos MeSH primário: |
Microbiota/fisiologia Vagina/microbiologia
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[Mh] Termos MeSH secundário: |
Adolescente Adulto Bifidobacterium/genética Bifidobacterium/fisiologia Corynebacterium/genética Corynebacterium/fisiologia Enterobacteriaceae/genética Enterobacteriaceae/fisiologia Feminino Seres Humanos Lactobacillus/genética Lactobacillus/fisiologia Microbiota/genética Países Baixos Proteus/genética Proteus/fisiologia RNA Ribossômico 16S/genética Staphylococcus/genética Staphylococcus/fisiologia Streptococcus/genética Streptococcus/fisiologia Adulto Jovem
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (RNA, Ribosomal, 16S) |
[Em] Mês de entrada: | 1709 |
[Cu] Atualização por classe: | 170925 |
[Lr] Data última revisão:
| 170925 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170713 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1371/journal.pone.0181135 |
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