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[PMID]:29197331
[Au] Autor:Addo KK; Addo SO; Mensah GI; Mosi L; Bonsu FA
[Ad] Endereço:Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, P.O. Box LG 581, Legon, Ghana. kaddo@noguchi.ug.edu.gh.
[Ti] Título:Genotyping and drug susceptibility testing of mycobacterial isolates from population-based tuberculosis prevalence survey in Ghana.
[So] Source:BMC Infect Dis;17(1):743, 2017 12 02.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mycobacterium tuberculosis complex (MTBC) and Non-tuberculosis Mycobacterium (NTM) infections differ clinically, making rapid identification and drug susceptibility testing (DST) very critical for infection control and drug therapy. This study aims to use World Health Organization (WHO) approved line probe assay (LPA) to differentiate mycobacterial isolates obtained from tuberculosis (TB) prevalence survey in Ghana and to determine their drug resistance patterns. METHODS: A retrospective study was conducted whereby a total of 361 mycobacterial isolates were differentiated and their drug resistance patterns determined using GenoType Mycobacterium Assays: MTBC and CM/AS for differentiating MTBC and NTM as well MTBDRplus and NTM-DR for DST of MTBC and NTM respectively. RESULTS: Out of 361 isolates, 165 (45.7%) MTBC and 120 (33.2%) NTM (made up of 14 different species) were identified to the species levels whiles 76 (21.1%) could not be completely identified. The MTBC comprised 161 (97.6%) Mycobacterium tuberculosis and 4 (2.4%) Mycobacterium africanum. Isoniazid and rifampicin monoresistant MTBC isolates were 18/165 (10.9%) and 2/165(1.2%) respectively whiles 11/165 (6.7%) were resistant to both drugs. Majority 42/120 (35%) of NTM were M. fortuitum. DST of 28 M. avium complex and 8 M. abscessus complex species revealed that all were susceptible to macrolides (clarithromycin, azithromycin) and aminoglycosides (kanamycin, amikacin, and gentamicin). CONCLUSION: Our research signifies an important contribution to TB control in terms of knowledge of the types of mycobacterium species circulating and their drug resistance patterns in Ghana.
[Mh] Termos MeSH primário: Mycobacterium tuberculosis/efeitos dos fármacos
Mycobacterium tuberculosis/genética
Micobactérias não Tuberculosas/genética
Tuberculose/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Claritromicina/farmacologia
Farmacorresistência Bacteriana/efeitos dos fármacos
Feminino
Genótipo
Gana
Seres Humanos
Isoniazida/farmacologia
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Infecções por Micobactéria não Tuberculosa/microbiologia
Mycobacterium tuberculosis/isolamento & purificação
Micobactérias não Tuberculosas/efeitos dos fármacos
Micobactérias não Tuberculosas/isolamento & purificação
Prevalência
Estudos Retrospectivos
Rifampina/farmacologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
H1250JIK0A (Clarithromycin); V83O1VOZ8L (Isoniazid); VJT6J7R4TR (Rifampin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171204
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2853-3


  2 / 2912 MEDLINE  
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[PMID]:28461147
[Au] Autor:Diel R; Ringshausen F; Richter E; Welker L; Schmitz J; Nienhaus A
[Ad] Endereço:Institute for Epidemiology, University Medical Hospital Schleswig-Holstein, Kiel. Member of the German Center for Lung Research (ARCN); Airway Research Center North (ARCN), German Center for Lung Research (DZL) LungClinic Grosshansdorf. Electronic address: roland.diel@epi.uni-kiel.de.
[Ti] Título:Microbiological and Clinical Outcomes of Treating Non-Mycobacterium Avium Complex Nontuberculous Mycobacterial Pulmonary Disease: A Systematic Review and Meta-Analysis.
[So] Source:Chest;152(1):120-142, 2017 07.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pulmonary disease caused by nontuberculous mycobacteria (NTM) is steadily increasing worldwide. METHODS: A systematic review of non-Mycobacterium avium complex studies published prior to October 2016 was conducted with respect to microbiological and clinical outcomes of current treatment regimens. RESULTS: We retrieved 352 citations, which yielded 24 studies eligible for evaluation. Sixteen studies were retrospective chart reviews, three studies were prospective, and only five studies were randomized. The weighted average proportion of sputum culture conversion (SCC) after subtracting posttreatment relapses for patients with M abscessus was 41.2% (95% CI, 28.6%-54.5%) but was 69.8% (95% CI, 41.0%-91.9%) with subspecies M massiliense in macrolide-containing regimens, 80.2% (95% CI, 58.4%-95.2%) in patients with M kansasii, 32.0% (95% CI, 16.5%-49.8%) for M xenopi (MX) and 54.4% (95% CI, 34.7%-73.4%) for M malmoense. SCCs in the total of 55 patients who underwent lung resection and had MX or M abscessus was high at 75.9%. The risk of bias was low in four of five randomized studies. However, heterogeneous use of outcome parameters (eight definitions of "relapse," eight of "treatment success," and four of "cure") hampered comparison of nonrandomized studies as well as producing possible bias by a posteriori exclusion (13.3%) and uncompleted treatment of participants (25.3%). CONCLUSIONS: As a sustained microbiological response without surgery is unsatisfactory in treating M abscessus, MX, and M malmoense, functional and quality of life aspects should be given more emphasis in the individual evaluation of treatment outcome. Further, properly planned studies with sufficient power are needed, as are new drugs or better-tolerated application of current antibiotics, or both.
[Mh] Termos MeSH primário: Pneumopatias
Infecções por Micobactéria não Tuberculosa
Complexo Mycobacterium avium
Micobactérias não Tuberculosas
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto
Gerenciamento Clínico
Seres Humanos
Pneumopatias/diagnóstico
Pneumopatias/microbiologia
Pneumopatias/terapia
Técnicas Microbiológicas/métodos
Infecções por Micobactéria não Tuberculosa/diagnóstico
Infecções por Micobactéria não Tuberculosa/microbiologia
Infecções por Micobactéria não Tuberculosa/terapia
Complexo Mycobacterium avium/efeitos dos fármacos
Complexo Mycobacterium avium/isolamento & purificação
Complexo Mycobacterium avium/patogenicidade
Micobactérias não Tuberculosas/efeitos dos fármacos
Micobactérias não Tuberculosas/isolamento & purificação
Micobactérias não Tuberculosas/patogenicidade
Avaliação de Processos e Resultados (Cuidados de Saúde)
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  3 / 2912 MEDLINE  
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[PMID]:29390337
[Au] Autor:González Saldaña N; Galvis Trujillo DM; Borbolla Pertierra AM; Mondragón Pineda AI; Juárez Olguín H
[Ad] Endereço:Department of Infectology, National Institute of Pediatrics.
[Ti] Título:Linezolid-associated optic neuropathy in a pediatric patient with Mycobacterium nonchromogenicum: A case report.
[So] Source:Medicine (Baltimore);96(50):e9200, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Toxic optic neuropathies are alterations of the optic nerve and can be caused by environmental, pharmacological, or nutritional agents. CASE: It is about a 7-year-old male patient, a native of the State of Mexico, Mexico who was diagnosed with cervical mycobacterial lymphadenitis that required management with linezolid. OBSERVATIONS: After 7 months of treatment, visual acuity of the left eye decreased and was accompanied by headache. Neuroinfection and other central nervous system affections were discarded. An adverse effect related to treatment with linezolid was suspected, and linezolid was suspended. The symptoms subsided after discontinuation; however, the patient continued to show decreased visual acuity of the left eye, assessed by his ability to count 2 fingers. The right eye remained unaffected. CONCLUSIONS: Neurotoxicity can be decreased by reducing the total dose of linezolid or by administrating it in an intermittent form. To avoid progression and loss of vision, we suggest frequent periodic ophthalmological evaluation in patients treated with linezolid.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Linezolida/efeitos adversos
Linfadenite/tratamento farmacológico
Linfadenite/microbiologia
Infecções por Micobactéria não Tuberculosa/tratamento farmacológico
Infecções por Micobactéria não Tuberculosa/microbiologia
Doenças do Nervo Óptico/induzido quimicamente
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Masculino
Micobactérias não Tuberculosas
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); ISQ9I6J12J (Linezolid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009200


  4 / 2912 MEDLINE  
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[PMID]:29388833
[Au] Autor:Honda JR; Bai X; Chan ED
[Ad] Endereço:1 National Jewish Health Denver, Colorado and.
[Ti] Título:Elucidating the Pathogenesis of Nontuberculous Mycobacterial Lung Disease: Lesson from the Six Blind Men and the Elephant.
[So] Source:Am J Respir Cell Mol Biol;58(2):142-143, 2018 02.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por Micobactéria não Tuberculosa/patologia
Micobactérias não Tuberculosas/patogenicidade
Mucosa Respiratória/microbiologia
Infecções Respiratórias/patologia
[Mh] Termos MeSH secundário: Células Epiteliais/metabolismo
Seres Humanos
Pulmão/microbiologia
Infecções por Micobactéria não Tuberculosa/microbiologia
Mucosa Respiratória/citologia
Mucosa Respiratória/metabolismo
Infecções Respiratórias/microbiologia
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2017-0317ED


  5 / 2912 MEDLINE  
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[PMID]:28749330
[Au] Autor:Aguilar-Ayala DA; Cnockaert M; André E; Andries K; Gonzalez-Y-Merchand JA; Vandamme P; Palomino JC; Martin A
[Ad] Endereço:2​Departmento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico 1​Laboratory of Microbiology, Ghent University, Gent, Belgium.
[Ti] Título:In vitro activity of bedaquiline against rapidly growing nontuberculous mycobacteria.
[So] Source:J Med Microbiol;66(8):1140-1143, 2017 Aug.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bedaquiline (BDQ) has been proven to be effective in the treatment of multidrug-resistant tuberculosis. We hypothesized that BDQ could be a potential agent to treat nontuberculous mycobacterial (NTM) infection. The objective of this study was to evaluate the in vitro activity of BDQ against rapidly growing mycobacteria by assessing the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) against 18 NTM strains. For MIC determination we performed the resazurin microtitre assay broth dilution, and for the MBC the c.f.u. was determined. BDQ exhibited a strong inhibitory effect against most NTM tested; however, for some NTM strains the MBC was significantly higher than the MIC. A new finding is that Mycobacterium flavescens has a mutation in the gene atpE associated with natural resistance to BDQ. These preliminary promising results demonstrate that BDQ could be potentially useful for the treatment of NTM.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Diarilquinolinas/farmacologia
Infecções por Micobactéria não Tuberculosa/microbiologia
Micobactérias não Tuberculosas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Seres Humanos
Testes de Sensibilidade Microbiana
Micobactérias não Tuberculosas/genética
Micobactérias não Tuberculosas/crescimento & desenvolvimento
Micobactérias não Tuberculosas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Diarylquinolines); 78846I289Y (bedaquiline)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000537


  6 / 2912 MEDLINE  
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[PMID]:29252632
[Au] Autor:Wanderman N; Thurn J; Wyffels M; Sembrano JN
[Ad] Endereço:Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
[Ti] Título:Successful Treatment of Mycobacterium gordonae Sacroiliitis Using a Novel Minimally Invasive Sacroiliac Joint Arthrodesis: A Case Report.
[So] Source:JBJS Case Connect;6(3):e55, 2016 Jul-Sep.
[Is] ISSN:2160-3251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE: A 43-year-old man with a history of well-controlled HIV (human immunodeficiency virus) infection presented with sacroiliac joint destruction from a Mycobacterium gordonae infection. A sacroiliac joint arthrodesis was performed using a minimally invasive technique utilizing both biologic fusion (allograft bone with rhBMP-2 [recombinant human bone morphogenetic protein-2]) and fixation with titanium ingrowth rods. CONCLUSION: To our knowledge, this is the first reported case of infectious sacroiliitis from a nontubercular mycobacterium (M. gordonae) treated with a combination of joint debridement, biologic fusion with bone graft, and nonbiologic functional fusion using titanium ingrowth rods, all performed in a minimally invasive fashion. This strategy effectively alleviated pain and preserved function at 2 years of follow-up.
[Mh] Termos MeSH primário: Artrodese/métodos
Infecções por Micobactéria não Tuberculosa/cirurgia
Micobactérias não Tuberculosas/isolamento & purificação
Articulação Sacroilíaca/cirurgia
Sacroileíte/cirurgia
[Mh] Termos MeSH secundário: Adulto
Infecções por HIV/complicações
Seres Humanos
Masculino
Infecções por Micobactéria não Tuberculosa/microbiologia
Sacroileíte/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.14.00190


  7 / 2912 MEDLINE  
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[PMID]:29272273
[Au] Autor:Agizew T; Basotli J; Alexander H; Boyd R; Letsibogo G; Auld A; Nyirenda S; Tedla Z; Mathoma A; Mathebula U; Pals S; Date A; Finlay A
[Ad] Endereço:Centers for Disease Control and Prevention, Gaborone, Botswana.
[Ti] Título:Higher-than-expected prevalence of non-tuberculous mycobacteria in HIV setting in Botswana: Implications for diagnostic algorithms using Xpert MTB/RIF assay.
[So] Source:PLoS One;12(12):e0189981, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Non-tuberculous mycobacteria (NTM) can cause pulmonary infection and disease especially among people living with HIV (PLHIV). PLHIV with NTM disease may clinically present with one of the four symptoms consistent with tuberculosis (TB). We describe the prevalence of NTM and Mycobacterium tuberculosis complex (MTBC) isolated among PLHIV who presented for HIV care and treatment. METHODS: All PLHIV patients presenting for HIV care and treatment services at 22 clinical sites in Botswana were offered screening for TB and were recruited. Patients who had ≥1 TB symptom were asked to submit sputa for Xpert MTB/RIF and culture. Culture growth was identified as NTM and MTBC using the SD-Bioline TB Ag MPT64 Kit and Ziehl Neelsen microscopy. NTM and MTBC isolates underwent species identification by the Hain GenoType CM and AS line probe assays. RESULTS: Among 16, 259 PLHIV enrolled 3068 screened positive for at least one TB symptom. Of these, 1940 submitted ≥1 sputum specimen, 427 (22%) patients had ≥1 positive-culture result identified phenotypically for mycobacterial growth. Of these 247 and 180 patients were identified as having isolates were NTM and MTBC, respectively. Of the 247 patients identified with isolates containing NTM; 19 were later excluded as not having NTM based on additional genotypic testing. Among the remaining 408 patients 228 (56%, 95% confidence interval, 46-66%) with NTM. M. intracellulare was the most common isolated (47.8%). Other NTMs commonly associated with pulmonary disease included M. malmoense (3.9%), M. avium (2.2%), M. abscessus (0.9%) and M. kansasii (0.4%). After excluding NTM isolates that were non-speciated and M. gordonae 154 (67.5%) of the NTM isolates were potential pathogens. CONCLUSIONS: In the setting of HIV care and treatment, over-half (56%) of a positive sputum culture among PLHIV with TB symptoms was NTM. Though we were not able to distinguish in our study NTM disease and colonization, the study suggests culture and species identification for PLHIV presenting with TB symptoms remains important to facilitate NTM diagnosis and hasten time to appropriate treatment.
[Mh] Termos MeSH primário: Algoritmos
Infecções por HIV/microbiologia
Infecções por Micobactéria não Tuberculosa/diagnóstico
Micobactérias não Tuberculosas/isolamento & purificação
[Mh] Termos MeSH secundário: Adulto
Botsuana
Feminino
Infecções por HIV/complicações
Seres Humanos
Masculino
Meia-Idade
Infecções por Micobactéria não Tuberculosa/complicações
Infecções por Micobactéria não Tuberculosa/microbiologia
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189981


  8 / 2912 MEDLINE  
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[PMID]:28459317
[Ti] Título:What is Nontuberculous Mycobacteria (NTM) Disease?
[So] Source:Am J Respir Crit Care Med;195(9):P17-P18, 2017 May 01.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Infecções por Micobactéria não Tuberculosa/tratamento farmacológico
Micobactérias não Tuberculosas
[Mh] Termos MeSH secundário: Tosse/etiologia
Fadiga/etiologia
Febre/etiologia
Hemoptise/etiologia
Seres Humanos
Infecções por Micobactéria não Tuberculosa/complicações
Infecções por Micobactéria não Tuberculosa/diagnóstico
Infecções por Micobactéria não Tuberculosa/fisiopatologia
Perda de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE; PATIENT EDUCATION HANDOUT
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1164/rccm.1959P17


  9 / 2912 MEDLINE  
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[PMID]:28957340
[Au] Autor:Schweitzer MD; Salamo O; Campos M; Schraufnagel DE; Sadikot R; Mirsaeidi M
[Ad] Endereço:Section of Pulmonary, Department of Medicine, Miami VA Medical Center, Miami, FL, United States of America.
[Ti] Título:Body habitus in patients with and without bronchiectasis and non-tuberculous mycobacteria.
[So] Source:PLoS One;12(9):e0185095, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Female gender, tall stature, presence of bronchiectasis are associated with pulmonary nontuberculous mycobacterial (NTM) infections. The biologic relationship between the body habitus and NTM infection is not well defined and the body habitus profile of the patients with NTM and concurrent bronchiectasis is completely unknown. METHODS: We conducted a case control study at the Miami VA Healthcare System and the University of Illinois Medical Center on patients with pulmonary NTM infections between 2010 and 2015. We compared pulmonary NTM subjects with and without bronchiectasis. NTM infection was confirmed by using the American Thoracic Society/ Infectious Disease Society of America criteria. Standard radiological criteria were used to define bronchiectasis in chest CT-scan. RESULTS: Two hundred twenty subjects with pulmonary NTM were enrolled in the study. Sixty six subjects (30%) had bronchiectasis on CT scan of the chest. Subjects in the bronchiectasis group included more women (p = 0.002) and were significantly older (p = 0.005). Those patients who had bronchiectasis tended to have a significantly lower weight (less than 50kg) and height ≤155 cm (p <0.0001 and p = 0.018, respectively). Kaplan-Meier analysis confirmed that subjects who had bronchiectasis were shorter and weighed less, after adjusting for gender. CONCLUSIONS: This study defines a new sub-phenotype of NTM subjects with bronchiectasis who tend to be short with lower body weight. Further studies are needed to better understand and define the body habitus profiles of this new sub-phenotype and their clinical implications.
[Mh] Termos MeSH primário: Bronquiectasia/complicações
Infecções por Micobactéria não Tuberculosa/complicações
Infecções por Micobactéria não Tuberculosa/microbiologia
Micobactérias não Tuberculosas/fisiologia
[Mh] Termos MeSH secundário: Idoso
Peso Corporal
Bronquiectasia/patologia
Comorbidade
Demografia
Feminino
Seres Humanos
Classificação Internacional de Doenças
Estimativa de Kaplan-Meier
Masculino
Análise Multivariada
Infecções por Micobactéria não Tuberculosa/diagnóstico por imagem
Micobactérias não Tuberculosas/isolamento & purificação
Fatores de Risco
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185095


  10 / 2912 MEDLINE  
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[PMID]:28953638
[Au] Autor:Chang PH; Chuang YC
[Ad] Endereço:aSchool of Medicine, Taipei Medical University bDepartment of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
[Ti] Título:Anti-interferon-γ autoantibody-associated disseminated Mycobacterium abscessus infection mimicking parotid cancer with multiple metastases: A case report.
[So] Source:Medicine (Baltimore);96(39):e8118, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Among the nontuberculous mycobacteria, Mycobacterium abscessus is a common cause of skin, soft tissue, and bone infections. However, disseminated M. abscessus infection that mimics cancer metastasis with an underlying relatively immunocompetent condition has rarely been reported. PATIENT CONCERNS: A nonsmoking 73-year-old man with an underlying relatively immunocompetent condition reported a 2-month history of a mass in the region of his right parotid gland that had been steadily increasing in size. DIAGNOSES: The head and neck computed tomography showed an avidly enhancing tumor with central necrosis in the right parotid region and lymphadenopathy bilaterally at neck levels II-V (<6 cm) with a necrotic core. The radiologist and otolaryngologist both suspected a diagnosis of right parotid gland cancer with metastasis. INTERVENTIONS: The necrotic tissue was removed surgically, and Mycobacterium culture showed M. abscessus. We collected a blood sample and detected anti-interferon-γ autoantibody. OUTCOMES: After 6 months of anti-M. abscessus treatment, physical examination showed remission of the parotid tumor, and axillary and supraclavicular lymphadenopathy. LESSONS: We report a case of disseminated M. abscessus infection, which involved parotid glands with multiple lymphadenopathies in a person with an underlying relatively immunocompetent condition. Possible underlying mechanisms such as anti-interferon-γ autoantibody-associated immunodeficiency should be considered in a patient with disseminated M. abscessus infection without a known immunocompromised condition.
[Mh] Termos MeSH primário: Linfadenopatia/diagnóstico
Infecções por Micobactéria não Tuberculosa/diagnóstico
Micobactérias não Tuberculosas
Doenças Parotídeas/diagnóstico
Neoplasias Parotídeas/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Autoanticorpos/sangue
Diagnóstico Diferencial
Seres Humanos
Interferon gama/imunologia
Linfadenopatia/imunologia
Linfadenopatia/microbiologia
Masculino
Infecções por Micobactéria não Tuberculosa/imunologia
Infecções por Micobactéria não Tuberculosa/microbiologia
Doenças Parotídeas/imunologia
Doenças Parotídeas/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008118



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