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[PMID]:27770417
[Au] Autor:Roy I; Mukherjee J; Gupta MN
[Ad] Endereço:Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab, India.
[Ti] Título:Cross-Linked Enzyme Aggregates for Applications in Aqueous and Nonaqueous Media.
[So] Source:Methods Mol Biol;1504:109-123, 2017.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Extensive cross-linking of a precipitate of a protein by a cross-linking reagent (glutaraldehyde has been most commonly used) creates an insoluble enzyme preparation called cross-linked enzyme aggregates (CLEAs). CLEAs show high stability and performance in conventional aqueous as well as nonaqueous media. These are also stable at fairly high temperatures. CLEAs with more than one kind of enzyme activity can be prepared, and such CLEAs are called combi-CLEAs or multipurpose CLEAs. Extent of cross-linking often influences their morphology, stability, activity, and enantioselectivity.
[Mh] Termos MeSH primário: Reagentes para Ligações Cruzadas/química
Enzimas Imobilizadas/química
Glutaral/química
[Mh] Termos MeSH secundário: Animais
Aspergillus niger/enzimologia
Burkholderia cepacia/enzimologia
Candida/enzimologia
Bovinos
Estabilidade Enzimática
Enzimas Imobilizadas/metabolismo
Hidrolases/química
Hidrolases/metabolismo
Lipase/química
Lipase/metabolismo
Penicilina Amidase/química
Penicilina Amidase/metabolismo
Poligalacturonase/química
Poligalacturonase/metabolismo
Agregados Proteicos
Soroalbumina Bovina/metabolismo
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 0 (Enzymes, Immobilized); 0 (Protein Aggregates); 27432CM55Q (Serum Albumin, Bovine); EC 3.- (Hydrolases); EC 3.1.1.3 (Lipase); EC 3.2.1.15 (Polygalacturonase); EC 3.5.1.11 (Penicillin Amidase); T3C89M417N (Glutaral)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


  2 / 1490 MEDLINE  
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[PMID]:28573851
[Au] Autor:Sánchez DA; Tonetto GM; Ferreira ML
[Ad] Endereço:Planta Piloto de Ingeniería Química (PLAPIQUI), Universidad Nacional del Sur (UNS)-CONICET , Camino La Carrindanga Km 7, CC 717, 8000 Bahía Blanca, Argentina.
[Ti] Título:Screening of Lipases with Unusual High Activity in the sn-2 Esterification of 1,3-Dicaprin under Mild Operating Conditions.
[So] Source:J Agric Food Chem;65(24):5010-5017, 2017 Jun 21.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this work, the synthesis of acylglycerides with high nutritional value was carried out by enzymatic esterification at sn-2 position of 1,3-dicaprin with palmitic acid. A comparative study of the performance of several biocatalysts according to the obtained products was carried out. The results obtained with several of the biocatalysts evaluated are very interesting, and it would be possible to use them to obtain a mixture of acylglycerides to act as a fat substitute. The final product was composed of about 90% of nutritionally attractive glycerides. These glycerides were medium-chain length triglycerides, medium-long chain triglycerides (mainly triglycerides with medium chain fatty acids at sn-1 and sn-3 positions and long chain fatty acid at sn-2 position), and 1,3-diglycerides. Pseudomonas fluorescens lipase and Burkholderia cepacia lipase immobilized on chitosan demonstrated unusual high activity in the sn-2 esterification of 1,3-dicaprin with palmitic acid at 45 °C and 12 h with 33% yield to 1,3-dicaproyl-2-palmitoyl glycerol. Burkholderia cepacia lipase has the advantage of being immobilized; however, BCL/chitosan has the advantages of being immobilized and therefore its easy recovery from the reaction media.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Burkholderia cepacia/enzimologia
Diglicerídeos/química
Proteínas Fúngicas/química
Lipase/química
Pseudomonas fluorescens/enzimologia
Rhizomucor/enzimologia
[Mh] Termos MeSH secundário: Biocatálise
Enzimas Imobilizadas/química
Esterificação
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Diglycerides); 0 (Enzymes, Immobilized); 0 (Fungal Proteins); 17598-93-5 (1,3-didecanoylglycerol); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01327


  3 / 1490 MEDLINE  
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[PMID]:28562673
[Au] Autor:Pillet F; Passot FM; Pasta F; Anton Leberre V; Bouet JY
[Ad] Endereço:Ingénierie des Systèmes Biologiques et des Procédés INRA UMR792, Institut National de la Recherche Agronomique, Institut National des Sciences Appliquées, Toulouse, France.
[Ti] Título:Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.
[So] Source:PLoS One;12(5):e0177056, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi) mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Burkholderia cepacia/genética
Centrômero
Cromossomos Bacterianos
Plasmídeos
Ressonância de Plasmônio de Superfície/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177056


  4 / 1490 MEDLINE  
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[PMID]:28364441
[Au] Autor:Gilljam M; Nyström U; Dellgren G; Skog I; Hansson L
[Ad] Endereço:Department of Respiratory Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
[Ti] Título:Survival after lung transplantation for cystic fibrosis in Sweden.
[So] Source:Eur J Cardiothorac Surg;51(3):571-576, 2017 03 01.
[Is] ISSN:1873-734X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Objectives: In Sweden, lung transplantation has been performed in patients with end-stage lung disease since 1990. We assessed survival after lung transplantation for cystic fibrosis (CF) with focus on early mortality and outcome for patients infected with certain multiresistant bacteria, considered a relative contraindication for lung transplantation. Methods: Review of CF and transplant databases and patient charts. The Kaplan-Meier method and log-rank test were used for survival analysis and group comparison. Results: From November 1991 to December 2014, 115 transplantations were performed in 106 CF patients (9 retransplantations): 3 heart-lung, 106 double lung-, 1 double lobar- and 5 single lung transplantations, constituting 13% (115/909) of all lung-transplant procedures performed in Sweden. The mean age at surgery was 31 (SD 10, range 10-61) years and there were 48% females. Overall 1-year survival after lung transplantation for CF was 86.4%, 5-year survival was 73.7% and 10-year survival was 62.4%. The mean and median survival after transplantation were 13.1 (95% confidence interval (CI): 11-15.3) and 14.6 (95% CI: 9.3-19.8) years, respectively, and there was no significant difference for gender or transplant centre. Extracorporeal membrane oxygenation was used as a bridge to transplantation in 11 cases and five patients received reconditioned lungs. Vascular and infectious complications contributed to eight deaths within the first three postoperative months. The mean survival for 14 patients infected pretransplant with Mycobacterium abscessus or Burkholderia cepacia complex was 8.8 (95% CI: 6.1-11.6) years compared to 13.2 (95% CI: 10.9-15.8) years for patients negative for these bacteria. Nineteen patients (14% of all listed), of whom three were listed for retransplantation, died while waiting a median time of 94 days (range 4 days-2.5 years) after listing. Conclusions: Survival after lung transplantation in Sweden is good, also for patients with pretransplant infection with M. abscessus or B. cepacia complex, and comparable to international data.
[Mh] Termos MeSH primário: Fibrose Cística/cirurgia
Transplante de Pulmão/mortalidade
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Antibioticoprofilaxia/métodos
Infecções por Burkholderia/complicações
Infecções por Burkholderia/tratamento farmacológico
Infecções por Burkholderia/mortalidade
Burkholderia cepacia/efeitos dos fármacos
Criança
Contraindicações
Fibrose Cística/complicações
Fibrose Cística/mortalidade
Farmacorresistência Bacteriana Múltipla
Seres Humanos
Imunossupressão/métodos
Estimativa de Kaplan-Meier
Transplante de Pulmão/métodos
Transplante de Pulmão/estatística & dados numéricos
Meia-Idade
Infecções por Mycobacterium/complicações
Infecções por Mycobacterium/tratamento farmacológico
Infecções por Mycobacterium/mortalidade
Infecções Oportunistas/complicações
Infecções Oportunistas/tratamento farmacológico
Infecções Oportunistas/mortalidade
Suécia/epidemiologia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE
[do] DOI:10.1093/ejcts/ezw328


  5 / 1490 MEDLINE  
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[PMID]:28324840
[Au] Autor:Luo S; Li L; Chen A; Zeng Q; Xia H; Gu JD
[Ad] Endereço:College of Resources and Environment, Hunan Agricultural University, Changsha 410128, PR China.
[Ti] Título:Biosorption of diethyl phthalate ester by living and nonliving Burkholderia cepacia and the role of its cell surface components.
[So] Source:Chemosphere;178:187-196, 2017 Jul.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, the dibutyl phthalate (DBP) binding properties of a DBP-tolerant bacterium (B. cepacia) were characterized in terms of adsorption kinetics and isotherm. Living and nonliving cells both exhibited rapid removal of DBP, achieving more than 80% of maximum sorption within 30 min of contact and reached the equilibrium after 3 h. The adsorption isotherms were well fitted with the Sips model and the nonliving cells have greater biosorption capacity and affinity for DBP than the living cells. Furthermore, the absence of an active mechanism dependent on metabolism implied that the DBP bioaccumulation by living cells was mainly attribute to passive surface binding. The optimum pH for DBP adsorption by living and nonliving cells were both observed to be 6.0. The biosorptive mechanism of DBP binding by B. cepacia was further confirmed by FTIR analysis and various chemical treatments. FTIR results indicated that the phosphate and CH groups on B. cepacia were the main bounding sites for DBP. Furthermore, 2.28, 2.15, 1.93 and 0.87 g of pretreated cells were obtained from 2.40 g of native cells via extracellular polymeric substances (EPS), superficial layer-capsule, lipids components and cell membrane removal treatments, respectively. Total binding amount of DBP on the native cells, EPS-removed cells, capsule-removed cells, lipids-extracted cells and membrane-removed cells were 26.69, 24.84, 24.93, 16.11 and 10.80 mg, respectively, suggesting that the cell wall lipids, proteins or peptidoglycan might play important roles in the sorption of DBP by B. cepacia. The information could be applied in understanding on the mobility, transport and ultimate fate of PAEs in soil and related environment.
[Mh] Termos MeSH primário: Burkholderia cepacia/química
Ácidos Ftálicos/química
[Mh] Termos MeSH secundário: Adsorção
Sítios de Ligação
Membrana Celular/metabolismo
Recuperação e Remediação Ambiental/métodos
Cinética
Solo
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phthalic Acids); 0 (Soil); UF064M00AF (diethyl phthalate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE


  6 / 1490 MEDLINE  
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[PMID]:28195433
[Au] Autor:Liu LH; Shih YH; Liu WL; Lin CH; Huang HY
[Ad] Endereço:Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li District, Taoyuan City, 320, Taiwan.
[Ti] Título:Enzyme Immobilized on Nanoporous Carbon Derived from Metal-Organic Framework: A New Support for Biodiesel Synthesis.
[So] Source:ChemSusChem;10(7):1364-1369, 2017 Apr 10.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this study, nanoporous carbon (NPC) derived from metal-organic framework was used as support for the immobilization of Burkholderia cepacia lipase. The decorated aluminum oxide within the mesoporous NPC improved the enzyme loading efficiency as well as the catalytic ability for the transesterification of soybean oil, thus making it a promising green and sustainable catalytic system for industrial application.
[Mh] Termos MeSH primário: Biocombustíveis
Carbono/química
Enzimas Imobilizadas/química
Lipase/química
Nanoporos
Compostos Organometálicos/química
[Mh] Termos MeSH secundário: Burkholderia cepacia/enzimologia
Técnicas de Química Sintética
Enzimas Imobilizadas/metabolismo
Esterificação
Lipase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biofuels); 0 (Enzymes, Immobilized); 0 (Organometallic Compounds); 7440-44-0 (Carbon); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700142


  7 / 1490 MEDLINE  
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[PMID]:28186714
[Au] Autor:Goyer I; Iseppon M; Thibault C; Abaji R; Krajinovic M; Autmizguine J
[Ad] Endereço:Department of Pharmacy, CHU Sainte-Justine.
[Ti] Título:Lactic Acidosis with Chloramphenicol Treatment in a Child with Cystic Fibrosis.
[So] Source:J Popul Ther Clin Pharmacol;24(1):40-45, 2017 Jan 30.
[Is] ISSN:1710-6222
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Children with cystic fibrosis are commonly colonized with multi-resistant bacteria. In such patients, infectious exacerbation may require salvage therapy with uncommonly used antimicrobials, including chloramphenicol. Chloramphenicol is rarely used nowadays because of the associated severe adverse events. We describe the case of a 15-year-old female with terminal cystic fibrosis who required intravenous (IV) chloramphenicol treatment for a Burkholderia cepacia (B. cepacia) exacerbation. The child subsequently developed lactic acidosis and secondary respiratory compensation adding to her baseline respiratory distress. Based on the Naranjo scale, the probability of chloramphenicol being the cause of the hyperlactatemia and associated respiratory distress was rated as probable, as the adverse effects resolved upon discontinuation of the drug. Subsequent genotyping for mitochondrial polymorphism (G3010A) confirmed a possible susceptibility to lactic acidosis from mitochondrial RNA-inhibiting agents such as chloramphenicol. Hyperlactatemia is a rare but life threatening adverse effect that has been previously reported with chloramphenicol exposure, but is not generally thought of. Clinicians should be aware of this potentially life threatening, but reversible adverse event. Lactate should be monitored under chloramphenicol and it should be discontinued as soon as this complication is suspected, especially in patients with low respiratory reserve.
[Mh] Termos MeSH primário: Acidose Láctica/induzido quimicamente
Infecções por Burkholderia/tratamento farmacológico
Infecções por Burkholderia/etiologia
Cloranfenicol/efeitos adversos
Fibrose Cística/complicações
[Mh] Termos MeSH secundário: Acidose Láctica/genética
Adolescente
Burkholderia cepacia
Cloranfenicol/uso terapêutico
Feminino
Genótipo
Seres Humanos
RNA/antagonistas & inibidores
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, mitochondrial); 63231-63-0 (RNA); 66974FR9Q1 (Chloramphenicol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.22374/1710-6222.24.1.5


  8 / 1490 MEDLINE  
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[PMID]:28154258
[Au] Autor:Saisyo A; Shimono R; Oie S; Kimura K; Furukawa H
[Ad] Endereço:Pharmaceutical Service, Yamaguchi University Hospital.
[Ti] Título:The Risk of Microbial Contamination in Multiple-Dose Preservative-Free Ophthalmic Preparations.
[So] Source:Biol Pharm Bull;40(2):182-186, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Multiple-dose ophthalmic preparations that do not contain preservatives carry high risks of microbial contamination. However, there are various types of hospital preparations, with different physicochemical properties. In the present study, we evaluated the association between physicochemical properties and microbial contamination in ophthalmic preparations. The investigated hospital preparations included ophthalmic preparations of physiological saline, 0.2% fluconazole, 0.5% vancomycin hydrochloride, and 2% cyclosporine. We investigated the microbial dynamics of each ophthalmic preparation and microbial contamination in ophthalmic preparations used by patients. Remarkable growth of Pseudomonas aeruginosa, Burkholderia cepacia, and Serratia marcescens was observed in ophthalmic preparations of physiological saline and 0.2% fluconazole. All tested microorganisms displayed decreased counts after inoculation in 0.5% vancomycin hydrochloride. In 2% cyclosporine, all investigated microorganisms were below the limit of detection after inoculation for 6 h. The microbial contamination rates of ophthalmic preparations used by patients were 16.7% (3/18 samples) for 0.5% vancomycin hydrochloride and 0% (0/30 samples) for 2% cyclosporine. All detected contaminants in 0.5% vancomycin hydrochloride were Candida spp., one of which was present at a level of 1×10 colony-forming units/mL. The storage method for in-use ophthalmic preparations should be considered on the basis of their physicochemical properties.
[Mh] Termos MeSH primário: Contaminação de Medicamentos
Soluções Oftálmicas/análise
Conservantes Farmacêuticos/análise
[Mh] Termos MeSH secundário: Burkholderia cepacia/isolamento & purificação
Contaminação de Medicamentos/prevenção & controle
Seres Humanos
Pseudomonas aeruginosa/isolamento & purificação
Fatores de Risco
Vancomicina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ophthalmic Solutions); 0 (Preservatives, Pharmaceutical); 6Q205EH1VU (Vancomycin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b16-00688


  9 / 1490 MEDLINE  
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[PMID]:28115168
[Au] Autor:Ramos KJ; Quon BS; Heltshe SL; Mayer-Hamblett N; Lease ED; Aitken ML; Weiss NS; Goss CH
[Ad] Endereço:Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington Medical Center, Seattle, WA. Electronic address: ramoskj@uw.edu.
[Ti] Título:Heterogeneity in Survival in Adult Patients With Cystic Fibrosis With FEV < 30% of Predicted in the United States.
[So] Source:Chest;151(6):1320-1328, 2017 Jun.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lung transplantation (LTx) is frequently considered for patients with cystic fibrosis (CF) when the FEV reaches < 30%. This study estimated transplant-free survival for patients with CF and an FEV < 30% and identified predictors of death without LTx. METHODS: We conducted a retrospective cohort study using the CF Foundation Patient Registry from January 1, 2003 to December 31, 2013. Adult patients (≥ 18 years) with FEV < 30% prior to LTx were included. We performed Kaplan-Meier survival estimates censored at LTx. Multivariable Cox proportional hazard regression identified predictors of mortality. RESULTS: There were 3,340 patients with an FEV < 30%. Death without LTx occurred in 1,250 patients (37.4%); 951 patients (28.5%) underwent LTx; 918 patients (27.5%) remained alive without LTx at the end of follow-up; and 221 patients (6.6%) were lost to follow-up. Median transplant-free survival after FEV < 30% was 6.6 years (95% CI, 5.9-7.0). Adjusted predictors of death without LTx included supplemental oxygen use (hazard ratio [HR], 2.1; 95% CI, 1.7-2.6), Burkholderia cepacia infection (HR, 1.8; 95% CI, 1.3-2.6), BMI ≤ 18 (HR, 1.6; 95% CI, 1.3-1.9), female sex (HR, 1.6; 95% CI, 1.2-2.0), CF-related diabetes in patients receiving insulin (HR, 1.4; 95% CI, 1.2-1.8), and ≥ one exacerbation per year (HR, 1.7; 95% CI, 1.3-2.2 vs. 0 exacerbations). CONCLUSIONS: Median survival was > 6.5 years for patients with CF and an FEV < 30%, exceeding prior survival estimates. There was substantial heterogeneity in survival, with some patients with CF dying soon after reaching this lung function threshold and others living for many years. For this reason, we conclude that FEV < 30% remains an important marker of disease severity for patients with CF. Patients with a supplemental oxygen requirement or frequent exacerbations should have prompt referral because of their increased risk of death.
[Mh] Termos MeSH primário: Fibrose Cística/fisiopatologia
Transplante de Pulmão
Pulmão/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Infecções por Burkholderia/epidemiologia
Burkholderia cepacia
Estudos de Coortes
Fibrose Cística/epidemiologia
Fibrose Cística/mortalidade
Fibrose Cística/terapia
Diabetes Mellitus/tratamento farmacológico
Diabetes Mellitus/epidemiologia
Progressão da Doença
Feminino
Volume Expiratório Forçado
Seres Humanos
Hipoglicemiantes/uso terapêutico
Insulina/uso terapêutico
Masculino
Oxigenoterapia
Prognóstico
Modelos de Riscos Proporcionais
Infecções por Pseudomonas/epidemiologia
Estudos Retrospectivos
Fatores Sexuais
Taxa de Sobrevida
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Insulin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


  10 / 1490 MEDLINE  
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[PMID]:27979420
[Au] Autor:Yan ST; Sun LC; Jia HB; Gao W; Yang JP; Zhang GQ
[Ad] Endereço:Department of Emergency Medicine, China-Japan Friendship Hospital, Beijing, China.
[Ti] Título:Procalcitonin levels in bloodstream infections caused by different sources and species of bacteria.
[So] Source:Am J Emerg Med;35(4):579-583, 2017 Apr.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to evaluate procalcitonin (PCT) diagnostic accuracy in discriminating gram-negative (GN) from gram-positive (GP) bloodstream infections and determining the relationship between PCT levels, infection sites, and pathogen types. METHODS: Clinical and laboratory data were collected from patients with blood culture (BC)-positive sepsis between January 2014 and December 2015. PCT levels at different infection sites were compared, as was the presence of GN and GP bloodstream infection. A receiver operating characteristic (ROC) curve was generated to assess diagnostic accuracy. RESULTS: Of the 486 monomicrobial BCs, 254 (52.26%) were positive for GN bacteria (GNB), and 202 (42.18%) for GP bacteria (GPB). Median PCT levels were higher in BCs positive for GN (2.42ng/ml, IQR: 0.38-15.52) than in those positive for GPB (0.49ng/ml, IQR: 0.13-5.89) (P<0.001). In the ROC analysis to differentiate between GNB and GPB, the area under the curve was 0.628 (95% CI: 0.576-0.679). When the cutoffs for PCT were 10.335 and 15.000ng/ml, the specificity of GNB infection was 80.2% and 84.2%, respectively. PCT levels caused by GNB differed between Escherichia coli and Acinetobacter baumanni/Burkholderia cepacia, Klebsiella pneumonia and Acinetobacter baumanni. PCT levels caused by GPB differed between Staphylococcus epidermidis/Staphylococcus aureus and Staphylococcus hominis/Staphylococcus haemolyticus, Enterococcus faecium and Enterococcus faecalis/S.hominis/S. haemolyticus. Among patients with known infection sites, there were statistical differences in PCT levels between abdominal infection and pneumonia/infective endocarditis, urinary tract infection and pneumonia/catheter-related infection/infective endocarditis. CONCLUSION: PCT can distinguish between GNB and GPB infection, as well as between different bacterial species and infection sites.
[Mh] Termos MeSH primário: Bacteriemia/sangue
Calcitonina/sangue
Infecções Relacionadas a Cateter/sangue
Endocardite Bacteriana/sangue
Infecções por Bactérias Gram-Negativas/sangue
Infecções por Bactérias Gram-Positivas/sangue
Pneumonia Bacteriana/sangue
Infecções Urinárias/sangue
[Mh] Termos MeSH secundário: Infecções por Acinetobacter/sangue
Infecções por Acinetobacter/microbiologia
Acinetobacter baumannii
Idoso
Idoso de 80 Anos ou mais
Bacteriemia/microbiologia
Biomarcadores/sangue
Infecções por Burkholderia/sangue
Infecções por Burkholderia/microbiologia
Burkholderia cepacia
Infecções Relacionadas a Cateter/microbiologia
Serviço Hospitalar de Emergência
Endocardite Bacteriana/microbiologia
Enterococcus faecalis
Enterococcus faecium
Escherichia coli
Infecções por Escherichia coli/sangue
Infecções por Escherichia coli/microbiologia
Feminino
Infecções por Bactérias Gram-Negativas/microbiologia
Infecções por Bactérias Gram-Positivas/microbiologia
Seres Humanos
Unidades de Terapia Intensiva
Infecções por Klebsiella/sangue
Infecções por Klebsiella/microbiologia
Klebsiella pneumoniae
Masculino
Meia-Idade
Pneumonia Bacteriana/microbiologia
Estudos Retrospectivos
Infecções Estafilocócicas/sangue
Infecções Estafilocócicas/microbiologia
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
Staphylococcus hominis
Infecções Urinárias/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 9007-12-9 (Calcitonin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE



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