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  1 / 13115 MEDLINE  
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[PMID]:29380441
[Au] Autor:Waugh CA; Arukwe A; Jaspers VLB
[Ad] Endereço:Environmental Toxicology, Department of Biology, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
[Ti] Título:Deregulation of microRNA-155 and its transcription factor NF-kB by polychlorinated biphenyls during viral infections.
[So] Source:APMIS;126(3):234-240, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Polychlorinated biphenyls (PCBs), and similar environmental contaminants, have been linked to virus outbreaks and increased viral induced mortality since the 1970s. Yet the mechanisms behind this increased susceptibility remain elusive. It has recently been illustrated that the innate immune viral detection system is tightly regulated by small non-coding RNAs, including microRNAs (miRNAs). For virus infections miRNA-155 expression is an important host response against infection, and deregulation of this miRNA is closely associated with adverse outcomes. Thus, we designed a targeted in vitro study using primary chicken fibroblasts, first exposed to a mixture of PCBs (Arochlor-1250) before being stimulated with a synthetic RNA virus (poly I:C), to determine if PCBs have the potential to deregulate miRNA-155. In this paper, we provide the first data for the deregulation of miRNA-155 when a host is exposed to a mixture of PCBs before a virus infection. Thus, we provide important evidence that PCBs can be involved in the deregulation of important miRNA pathways involved in the immune system; thereby demonstrating novel insights into the mechanism of PCB toxicity on the immune system.
[Mh] Termos MeSH primário: Imunidade Inata/genética
MicroRNAs/genética
NF-kappa B/genética
Poli I-C/farmacologia
Bifenilos Policlorados/química
Vírus/imunologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Embrião de Galinha
Galinhas/genética
Galinhas/imunologia
Regulação da Expressão Gênica/imunologia
Seres Humanos
Viroses/genética
Viroses/imunologia
Viroses/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MIRN155 microRNA, human); 0 (MicroRNAs); 0 (NF-kappa B); DFC2HB4I0K (Polychlorinated Biphenyls); O84C90HH2L (Poly I-C)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12811


  2 / 13115 MEDLINE  
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[PMID]:29496868
[Au] Autor:Kim JS
[Ad] Endereço:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea. jskim01@snu.ac.kr.
[Ti] Título:Microbial warfare against viruses.
[So] Source:Science;359(6379):993, 2018 03 02.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Bactérias/genética
Vírus
[Mh] Termos MeSH secundário: Bacteriófagos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180303
[St] Status:MEDLINE
[do] DOI:10.1126/science.aas9430


  3 / 13115 MEDLINE  
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[PMID]:28461690
[Au] Autor:Mirzaei MK; Maurice CF
[Ad] Endereço:Department of Microbiology and Immunology, Microbiome Disease and Tolerance Centre, McGill University, 3775 University Street, Montreal, Quebec H3H 2B4, Canada.
[Ti] Título:Ménage à trois in the human gut: interactions between host, bacteria and phages.
[So] Source:Nat Rev Microbiol;15(7):397-408, 2017 07.
[Is] ISSN:1740-1534
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The human gut is host to one of the densest microbial communities known, the gut microbiota, which contains bacteria, archaea, viruses, fungi and other microbial eukaryotes. Bacteriophages in the gut are largely unexplored, despite their potential to regulate bacterial communities and thus human health. In addition to helping us understand gut homeostasis, applying an ecological perspective to the study of bacterial and phage communities in the gut will help us to understand how this microbial system functions. For example, temporal studies of bacteria, phages and host immune cells in the gut during health and disease could provide key information about disease development and inform therapeutic treatments, whereas understanding the regulation of the replication cycles of phages could help harness the gut microbiota to improve disease outcomes. As the most abundant biological entities in our gut, we must consider bacteriophages in our pursuit of personalized medicine.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Bacteriófagos/fisiologia
Microbioma Gastrointestinal
Interações Microbianas
[Mh] Termos MeSH secundário: Bactérias/classificação
Bactérias/virologia
Infecções Bacterianas/terapia
Seres Humanos
Medicina de Precisão/métodos
Vírus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1038/nrmicro.2017.30


  4 / 13115 MEDLINE  
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[PMID]:28456056
[Au] Autor:Poirier EZ; Vignuzzi M
[Ad] Endereço:Institut Pasteur, Centre National de la Recherche Scientifique, UMR 3569, Paris, France; University of Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, Paris, France.
[Ti] Título:Virus population dynamics during infection.
[So] Source:Curr Opin Virol;23:82-87, 2017 04.
[Is] ISSN:1879-6265
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:During RNA virus infection of a host, error-prone viral replication will give rise to a cloud of genetically-linked mutants, as well as truncated, defective genomes. In this review, we describe the dynamics of viral diversity during infection, illustrating that the viral population fluctuates greatly in number of genomes and composition of mutants, in relation with the existence of physical barriers or immune pressures. We illustrate the importance of generating diversity by analyzing the case of fidelity variants, largely attenuated in vivo. Recombination is also considered in its various roles: redistribution of mutations on full-length genomes, and production of highly-immunostimulatory defective genomes. We cover these notions by underlining, when they exist, the differences between acute and persistent infections.
[Mh] Termos MeSH primário: Variação Genética
Dinâmica Populacional
Infecções por Vírus de RNA/virologia
Vírus/crescimento & desenvolvimento
Vírus/genética
[Mh] Termos MeSH secundário: Genética Populacional
Vírus/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  5 / 13115 MEDLINE  
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[PMID]:29324229
[Au] Autor:Jones MK; Karst SM
[Ad] Endereço:Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA.
[Ti] Título:Enteric Viruses Hitch a Ride on the Evolutionary Highway.
[So] Source:Cell Host Microbe;23(1):5-6, 2018 01 10.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RNA viruses can recombine their genetic material during co-infection. However, the in vivo frequency of co-infections is unclear. In this issue of Cell Host & Microbe, Erickson et al. (2018) demonstrate that an enteric RNA virus concentrates itself through multi-virion binding to bacteria, thus increasing genetic recombination and virus adaptability.
[Mh] Termos MeSH primário: Evolução Biológica
Vírus de RNA/genética
[Mh] Termos MeSH secundário: Coinfecção
Vírus de DNA
Vírus
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  6 / 13115 MEDLINE  
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[PMID]:28462524
[Au] Autor:Upton JW; Shubina M; Balachandran S
[Ad] Endereço:Department of Molecular Biosciences, LaMontagne Center for Infectious Disease, University of Texas, Austin, TX, USA.
[Ti] Título:RIPK3-driven cell death during virus infections.
[So] Source:Immunol Rev;277(1):90-101, 2017 05.
[Is] ISSN:1600-065X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The programmed self-destruction of infected cells is a powerful antimicrobial strategy in metazoans. For decades, apoptosis represented the dominant mechanism by which the virus-infected cell was thought to undergo programmed cell death. More recently, however, new mechanisms of cell death have been described that are also key to host defense. One such mechanism in vertebrates is programmed necrosis, or "necroptosis", driven by receptor-interacting protein kinase 3 (RIPK3). Once activated by innate immune stimuli, including virus infections, RIPK3 phosphorylates the mixed lineage kinase domain-like protein (MLKL), which then disrupts cellular membranes to effect necroptosis. Emerging evidence demonstrates that RIPK3 can also mediate apoptosis and regulate inflammasomes. Here, we review studies on the mechanisms by which viruses activate RIPK3 and the pathways engaged by RIPK3 that drive cell death.
[Mh] Termos MeSH primário: Inflamassomos/metabolismo
Proteínas Quinases/metabolismo
Proteína Serina-Treonina Quinases de Interação com Receptores/metabolismo
Viroses/imunologia
Vírus/imunologia
[Mh] Termos MeSH secundário: Animais
Apoptose
Seres Humanos
Imunidade Inata
Necrose
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Inflammasomes); EC 2.7.- (MLKL protein, human); EC 2.7.- (Protein Kinases); EC 2.7.11.1 (RIPK3 protein, human); EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/imr.12539


  7 / 13115 MEDLINE  
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[PMID]:29371626
[Au] Autor:Carradec Q; Pelletier E; Da Silva C; Alberti A; Seeleuthner Y; Blanc-Mathieu R; Lima-Mendez G; Rocha F; Tirichine L; Labadie K; Kirilovsky A; Bertrand A; Engelen S; Madoui MA; Méheust R; Poulain J; Romac S; Richter DJ; Yoshikawa G; Dimier C; Kandels-Lewis S; Picheral M; Searson S; Jaillon O; Aury JM; Karsenti E; Sullivan MB; Sunagawa S; Bork P; Not F; Hingamp P; Raes J; Guidi L; Ogata H; de Vargas C; Iudicone D; Bowler C; Wincker P; Tara Oceans Coordinators
[Ad] Endereço:CEA - Institut de Biologie François Jacob, Genoscope, Evry, 91057, France.
[Ti] Título:A global ocean atlas of eukaryotic genes.
[So] Source:Nat Commun;9(1):373, 2018 01 25.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:While our knowledge about the roles of microbes and viruses in the ocean has increased tremendously due to recent advances in genomics and metagenomics, research on marine microbial eukaryotes and zooplankton has benefited much less from these new technologies because of their larger genomes, their enormous diversity, and largely unexplored physiologies. Here, we use a metatranscriptomics approach to capture expressed genes in open ocean Tara Oceans stations across four organismal size fractions. The individual sequence reads cluster into 116 million unigenes representing the largest reference collection of eukaryotic transcripts from any single biome. The catalog is used to unveil functions expressed by eukaryotic marine plankton, and to assess their functional biogeography. Almost half of the sequences have no similarity with known proteins, and a great number belong to new gene families with a restricted distribution in the ocean. Overall, the resource provides the foundations for exploring the roles of marine eukaryotes in ocean ecology and biogeochemistry.
[Mh] Termos MeSH primário: Organismos Aquáticos
Eucariotos/genética
Células Eucarióticas/metabolismo
Metagenoma
Filogenia
Zooplâncton/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Atlas como Assunto
Bactérias/classificação
Bactérias/genética
Biodiversidade
Ecossistema
Eucariotos/classificação
Células Eucarióticas/citologia
Metagenômica/métodos
Oceanos e Mares
Fitoplâncton/classificação
Fitoplâncton/genética
Água do Mar
Vírus/classificação
Vírus/genética
Zooplâncton/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02342-1


  8 / 13115 MEDLINE  
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[PMID]:29223400
[Au] Autor:Oba M; Tsuchiaka S; Omatsu T; Katayama Y; Otomaru K; Hirata T; Aoki H; Murata Y; Makino S; Nagai M; Mizutani T
[Ad] Endereço:Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
[Ti] Título:A new comprehensive method for detection of livestock-related pathogenic viruses using a target enrichment system.
[So] Source:Biochem Biophys Res Commun;495(2):1871-1877, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We tested usefulness of a target enrichment system SureSelect, a comprehensive viral nucleic acid detection method, for rapid identification of viral pathogens in feces samples of cattle, pigs and goats. This system enriches nucleic acids of target viruses in clinical/field samples by using a library of biotinylated RNAs with sequences complementary to the target viruses. The enriched nucleic acids are amplified by PCR and subjected to next generation sequencing to identify the target viruses. In many samples, SureSelect target enrichment method increased efficiencies for detection of the viruses listed in the biotinylated RNA library. Furthermore, this method enabled us to determine nearly full-length genome sequence of porcine parainfluenza virus 1 and greatly increased Breadth, a value indicating the ratio of the mapping consensus length in the reference genome, in pig samples. Our data showed usefulness of SureSelect target enrichment system for comprehensive analysis of genomic information of various viruses in field samples.
[Mh] Termos MeSH primário: Mapeamento Cromossômico/veterinária
Efeito Citopatogênico Viral/genética
Genoma Viral/genética
Sequenciamento de Nucleotídeos em Larga Escala/veterinária
Gado/virologia
Vírus/genética
Vírus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Bovinos
Mapeamento Cromossômico/métodos
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Suínos
Vírus/patogenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


  9 / 13115 MEDLINE  
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[PMID]:28458037
[Au] Autor:Okesli A; Khosla C; Bassik MC
[Ad] Endereço:Departments of Chemistry, Genetics, and Chemical Engineering, and Stanford ChEM-H, Stanford University, Stanford, CA 94305, United States.
[Ti] Título:Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy.
[So] Source:Curr Opin Biotechnol;48:127-134, 2017 Dec.
[Is] ISSN:1879-0429
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The development of broad-spectrum, host-acting antiviral therapies remains an important but elusive goal in anti-infective drug discovery. To replicate efficiently, viruses not only depend on their hosts for an adequate supply of pyrimidine nucleotides, but also up-regulate pyrimidine nucleotide biosynthesis in infected cells. In this review, we outline our understanding of mammalian de novo and salvage metabolic pathways for pyrimidine nucleotide biosynthesis. The available spectrum of experimental and FDA-approved drugs that modulate individual steps in these metabolic pathways is also summarized. The logic of a host-acting combination antiviral therapy comprised of inhibitors of dihydroorotate dehydrogenase and uridine/cytidine kinase is discussed.
[Mh] Termos MeSH primário: Antivirais/uso terapêutico
Inibidores Enzimáticos/uso terapêutico
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/antagonistas & inibidores
Nucleotídeos de Pirimidina/biossíntese
Vírus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Seres Humanos
Vírus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Enzyme Inhibitors); 0 (Pyrimidine Nucleotides); EC 1.3.- (Oxidoreductases Acting on CH-CH Group Donors); EC 1.3.5.2 (dihydroorotate dehydrogenase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  10 / 13115 MEDLINE  
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[PMID]:29364606
[Au] Autor:Rumyantseva KV; Kosolapova NG; Kosolapov DB
[Ti] Título:[Relations between Bacterioplankton, Heterotrophic Nanoflagellates, and Virioplankton in the Littoral Zone of a LarRe Plain Reservoir:. ImDact of Bird Colonies.]
[So] Source:Mikrobiologiia;85(5):588-597, 2016 Sep.
[Is] ISSN:0026-3656
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Interactions of the main components of microbial planktonic food web (bacteria, heterotrophic nanoflagellates, and viruses) were studied in a protected overgrown littoral zone of the Rybinsk Reservoir (Upper Volga).. The effect of bird colonial, settlements (the Laridae family) on these processes was deter- mined. The following systems exhibited significant negative correlations: "heterotrophic nanoflagellates- large rod-shaped bacteria" ("predator-prey"), "viruses-bacteriophages-bacterial products" ("parasite-. host") and "heterotrophic nanoflagellates-viruses-bacteriophages." Relations between biotic factors con- trolling bacterial development were more pronounced outside the zone affected by colonial bird settlements. Near the bird colony the role of viruses in mortality of planktonic bacteria increased. Reproduction of bacte- rial cells accelerated in response to the increase in feeding activity of heterotrophic nanoflagellates. Viruses- bacteriophages and heterotrophic nanoflagellates probably eliminate different targets until medium-sized cells become predominant in the bacterial community. Then heterotrophic nanoflagellates consume bacterial cells infected with viruses.
[Mh] Termos MeSH primário: Bactérias/crescimento & desenvolvimento
Charadriiformes/fisiologia
Dinoflagelados/crescimento & desenvolvimento
Processos Heterotróficos/fisiologia
Plâncton/crescimento & desenvolvimento
Vírus/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Bactérias/virologia
Carga Bacteriana
Contagem de Células
Dinoflagelados/microbiologia
Dinoflagelados/virologia
Ecossistema
Cadeia Alimentar
Plâncton/microbiologia
Plâncton/virologia
Tanques/microbiologia
Tanques/virologia
Federação Russa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE



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