Base de dados : MEDLINE
Pesquisa : B04.123 [Categoria DeCS]
Referências encontradas : 14643 [refinar]
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  1 / 14643 MEDLINE  
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[PMID]:29496868
[Au] Autor:Kim JS
[Ad] Endereço:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea. jskim01@snu.ac.kr.
[Ti] Título:Microbial warfare against viruses.
[So] Source:Science;359(6379):993, 2018 03 02.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Bactérias/genética
Vírus
[Mh] Termos MeSH secundário: Bacteriófagos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180303
[St] Status:MEDLINE
[do] DOI:10.1126/science.aas9430


  2 / 14643 MEDLINE  
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[PMID]:28461690
[Au] Autor:Mirzaei MK; Maurice CF
[Ad] Endereço:Department of Microbiology and Immunology, Microbiome Disease and Tolerance Centre, McGill University, 3775 University Street, Montreal, Quebec H3H 2B4, Canada.
[Ti] Título:Ménage à trois in the human gut: interactions between host, bacteria and phages.
[So] Source:Nat Rev Microbiol;15(7):397-408, 2017 07.
[Is] ISSN:1740-1534
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The human gut is host to one of the densest microbial communities known, the gut microbiota, which contains bacteria, archaea, viruses, fungi and other microbial eukaryotes. Bacteriophages in the gut are largely unexplored, despite their potential to regulate bacterial communities and thus human health. In addition to helping us understand gut homeostasis, applying an ecological perspective to the study of bacterial and phage communities in the gut will help us to understand how this microbial system functions. For example, temporal studies of bacteria, phages and host immune cells in the gut during health and disease could provide key information about disease development and inform therapeutic treatments, whereas understanding the regulation of the replication cycles of phages could help harness the gut microbiota to improve disease outcomes. As the most abundant biological entities in our gut, we must consider bacteriophages in our pursuit of personalized medicine.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Bacteriófagos/fisiologia
Microbioma Gastrointestinal
Interações Microbianas
[Mh] Termos MeSH secundário: Bactérias/classificação
Bactérias/virologia
Infecções Bacterianas/terapia
Seres Humanos
Medicina de Precisão/métodos
Vírus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1038/nrmicro.2017.30


  3 / 14643 MEDLINE  
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[PMID]:29241037
[Au] Autor:Khan Mirzaei M; Maurice CF
[Ad] Endereço:Department of Microbiology and Immunology, Microbiome and Disease Tolerance Centre, McGill University, Montreal, Canada.
[Ti] Título:The Mammalian Gut as a Matchmaker.
[So] Source:Cell Host Microbe;22(6):726-727, 2017 12 13.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dynamics of phages and bacteria in the gut may play key roles in human health. In this issue of Cell Host & Microbe, De Sordi et al. (2017) provide insights into phage-bacteria interactions, finding that microbial communities contribute to phage persistence in the mammalian gut by supplying new hosts.
[Mh] Termos MeSH primário: Bacteriófagos
Mamíferos
[Mh] Termos MeSH secundário: Animais
Bactérias
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  4 / 14643 MEDLINE  
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[PMID]:28468593
[Au] Autor:Ikemoto H; Lingasamy P; Anton Willmore AM; Hunt H; Kurm K; Tammik O; Scodeller P; Simón-Gracia L; Kotamraju VR; Lowy AM; Sugahara KN; Teesalu T
[Ad] Endereço:1 Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
[Ti] Título:Hyaluronan-binding peptide for targeting peritoneal carcinomatosis.
[So] Source:Tumour Biol;39(5):1010428317701628, 2017 May.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Peritoneal carcinomatosis results from dissemination of solid tumors in the peritoneal cavity, and is a common site of metastasis in patients with carcinomas of gastrointestinal or gynecological origin. Peritoneal carcinomatosis treatment is challenging as poorly vascularized, disseminated peritoneal micro-tumors are shielded from systemic anticancer drugs and drive tumor regrowth. Here, we describe the identification and validation of a tumor homing peptide CKRDLSRRC (IP3), which upon intraperitoneal administration delivers payloads to peritoneal metastases. IP3 peptide was identified by in vivo phage display on a mouse model of peritoneal carcinomatosis of gastric origin (MKN-45P), using high-throughput sequencing of the peptide-encoding region of phage genome as a readout. The IP3 peptide contains a hyaluronan-binding motif, and fluorescein-labeled IP3 peptide bound to immobilized hyaluronan in vitro. After intraperitoneal administration in mice bearing peritoneal metastases of gastric and colon origin, IP3 peptide homed robustly to macrophage-rich regions in peritoneal tumors, including poorly vascularized micro-tumors. Finally, we show that IP3 functionalization conferred silver nanoparticles the ability to home to peritoneal tumors of gastric and colonic origin, suggesting that it could facilitate targeted delivery of nanoscale payloads to peritoneal tumors. Collectively, our study suggests that the IP3 peptide has potential applications for targeting drugs, nanoparticles, and imaging agents to peritoneal tumors.
[Mh] Termos MeSH primário: Carcinoma/tratamento farmacológico
Receptores de Hialuronatos/administração & dosagem
Peptídeos/administração & dosagem
Neoplasias Peritoneais/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Bacteriófagos/genética
Carcinoma/genética
Carcinoma/patologia
Linhagem Celular Tumoral
Modelos Animais de Doenças
Sistemas de Liberação de Medicamentos
Seres Humanos
Receptores de Hialuronatos/genética
Camundongos
Nanopartículas/administração & dosagem
Nanopartículas/química
Metástase Neoplásica
Peptídeos/genética
Cavidade Peritoneal/patologia
Neoplasias Peritoneais/genética
Neoplasias Peritoneais/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hyaluronan Receptors); 0 (Peptides)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317701628


  5 / 14643 MEDLINE  
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[PMID]:29304128
[Au] Autor:Wang M; Zhai L; Yu W; Wei Y; Wang L; Liu S; Li W; Li X; Yu S; Chen X; Zhang H; Chen J; Feng Z; Yu L; Cui Y
[Ad] Endereço:College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, P.R. China.
[Ti] Título:Identification of a protective B-cell epitope of the Staphylococcus aureus GapC protein by screening a phage-displayed random peptide library.
[So] Source:PLoS One;13(1):e0190452, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The impact of epidemic Staphylococcus aureus (S. aureus) on public health is increasing. Because of the abuse of antibiotics, the antibiotic resistance of S. aureus is increasing. Thus, there is an urgent need to develop new immunotherapies and immunoprophylaxes. Previous studies showed that the GapC protein of S. aureus, which is a surface protein with high glyceraldehyde 3-phosphate dehydrogenase activity, transferrin binding activity, and other biological activities, is highly conserved. GapC induces an effective humoral immune response in vivo. However, the B-cell epitopes of S. aureus GapC have not been well identified. Here we used the bioinformatics tools to analyze the sequence of GapC, and we generated protective anti-GapC monoclonal antibodies (mAbs). A protective mAb (1F4) showed strong specificity to GapC and the ability to induce macrophages to phagocytose S. aureus. We screened the motif 272GYTEDEIVSSD282, which was recognized by mAb 1F4, using a phage display system. Then, we used site-directed mutagenesis to identify key amino acids in the motif. Residues G272 D276 E277 I278 and V279 formed the core of the 272GYTEDEIVSSD282 motif. In addition, we showed that this epitope peptide induced a protective humoral immune response against S. aureus infection in immunized mice. Our results will be useful for the further study of epitope-based vaccines against S. aureus infection.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/imunologia
Antígenos de Bactérias/imunologia
Linfócitos B/imunologia
Proteínas de Bactérias/imunologia
Bacteriófagos/genética
Epitopos/imunologia
Biblioteca de Peptídeos
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Anticorpos Antibacterianos/biossíntese
Anticorpos Monoclonais/imunologia
Ensaio de Imunoadsorção Enzimática
Epitopos/química
Macrófagos/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Mutagênese Sítio-Dirigida
Fagocitose
Estrutura Terciária de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Antibodies, Monoclonal); 0 (Antigens, Bacterial); 0 (Bacterial Proteins); 0 (Epitopes); 0 (GapC protein, Streptococcus); 0 (Peptide Library)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190452


  6 / 14643 MEDLINE  
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[PMID]:28749735
[Au] Autor:Borges AL; Davidson AR; Bondy-Denomy J
[Ad] Endereço:Department of Microbiology and Immunology, University of California, San Francisco, California 94158; email: joseph.bondy-denomy@ucsf.edu.
[Ti] Título:The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs.
[So] Source:Annu Rev Virol;4(1):37-59, 2017 Sep 29.
[Is] ISSN:2327-0578
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bacteria and archaea use CRISPR-Cas adaptive immune systems to defend themselves from infection by bacteriophages (phages). These RNA-guided nucleases are powerful weapons in the fight against foreign DNA, such as phages and plasmids, as well as a revolutionary gene editing tool. Phages are not passive bystanders in their interactions with CRISPR-Cas systems, however; recent discoveries have described phage genes that inhibit CRISPR-Cas function. More than 20 protein families, previously of unknown function, have been ascribed anti-CRISPR function. Here, we discuss how these CRISPR-Cas inhibitors were discovered and their modes of action were elucidated. We also consider the potential impact of anti-CRISPRs on bacterial and phage evolution. Finally, we speculate about the future of this field.
[Mh] Termos MeSH primário: Bactérias/genética
Bacteriófagos/genética
Bacteriófagos/fisiologia
Sistemas CRISPR-Cas
Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas
Evolução Molecular
[Mh] Termos MeSH secundário: Archaea/genética
Bactérias/virologia
Bacteriófagos/metabolismo
Edição de Genes
Proteínas Virais/genética
Proteínas Virais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1146/annurev-virology-101416-041616


  7 / 14643 MEDLINE  
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[PMID]:29293585
[Au] Autor:Herr KL; Carey AM; Heckman TI; Chávez JL; Johnson CN; Harvey E; Gamroth WA; Wulfing BS; Van Kessel RA; Marks ME
[Ad] Endereço:Department of Biology, Willamette University, Salem, OR, United States of America.
[Ti] Título:Exopolysaccharide production in Caulobacter crescentus: A resource allocation trade-off between protection and proliferation.
[So] Source:PLoS One;13(1):e0190371, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Complex and interacting selective pressures can produce bacterial communities with a range of phenotypes. One measure of bacterial success is the ability of cells or populations to proliferate while avoiding lytic phage infection. Resistance against bacteriophage infection can occur in the form of a metabolically expensive exopolysaccharide capsule. Here, we show that in Caulobacter crescentus, presence of an exopolysaccharide capsule provides measurable protection against infection from a lytic paracrystalline S-layer bacteriophage (CR30), but at a metabolic cost that reduces success in a phage-free environment. Carbon flux through GDP-mannose 4,6 dehydratase in different catabolic and anabolic pathways appears to mediate this trade-off. Together, our data support a model in which diversity in bacterial communities may be maintained through variable selection on phenotypes utilizing the same metabolic pathway.
[Mh] Termos MeSH primário: Caulobacter crescentus/metabolismo
Polissacarídeos/metabolismo
[Mh] Termos MeSH secundário: Bacteriófagos/genética
Caulobacter crescentus/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polysaccharides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190371


  8 / 14643 MEDLINE  
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[PMID]:29284014
[Au] Autor:Katharios P; Kalatzis PG; Kokkari C; Sarropoulou E; Middelboe M
[Ad] Endereço:Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research, Crete, Greece.
[Ti] Título:Isolation and characterization of a N4-like lytic bacteriophage infecting Vibrio splendidus, a pathogen of fish and bivalves.
[So] Source:PLoS One;12(12):e0190083, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel virulent bacteriophage, vB_VspP_pVa5, infecting a strain of Vibrio splendidus was isolated from a sea-cage aquaculture farm in Greece, and characterized using microbiological methods and genomic analysis. Bacteriophage vB_VspP_pVa5 is a N4-like podovirus with an icosahedral head measuring 85 nm in length and a short non-contractile tail. The phage had a narrow host range infecting only the bacterial host, a latent period of 30 min and a burst size of 24 virions per infected bacterium. Its genome size was 78,145 bp and genomic analysis identified 107 densely-packed genes, 40 of which could be annotated. In addition to the very large virion encapsulated DNA-dependent RNA polymerase which is the signature of the N4-like genus, an interesting feature of the novel phage is the presence of a self-splicing group I intron in the thymidylate synthase gene. A tRNAStop interrupted by a ~2.5kb open reading frame-containing area was also identified. The absence of genes related to lysogeny along with the high efficacy observed during in vitro cell lysis trials, indicate that the vB_VspP_pVa5 is a potential candidate component in a bacteriophage cocktail suitable for the biological control of V. splendidus in aquaculture.
[Mh] Termos MeSH primário: Bacteriófagos/isolamento & purificação
Bivalves/microbiologia
Peixes/microbiologia
Vibrio/virologia
[Mh] Termos MeSH secundário: Animais
Aquicultura
Microscopia Eletrônica de Transmissão
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190083


  9 / 14643 MEDLINE  
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[PMID]:29293334
[Au] Autor:Qiu Y; Li P; Dong S; Zhang X; Yang Q; Wang Y; Ge J; Hammock BD; Zhang C; Liu X
[Ad] Endereço:Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology,Key Laboratory of Control Technology and Standard for Agro-product Safety and Quality (Ministry of Agriculture), Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural
[Ti] Título:Phage-Mediated Competitive Chemiluminescent Immunoassay for Detecting Cry1Ab Toxin by Using an Anti-Idiotypic Camel Nanobody.
[So] Source:J Agric Food Chem;66(4):950-956, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cry toxins have been widely used in genetically modified organisms for pest control, raising public concern regarding their effects on the natural environment and food safety. In this work, a phage-mediated competitive chemiluminescent immunoassay (c-CLIA) was developed for determination of Cry1Ab toxin using anti-idiotypic camel nanobodies. By extracting RNA from camels' peripheral blood lymphocytes, a naive phage-displayed nanobody library was established. Using anti-Cry1Ab toxin monoclonal antibodies (mAbs) against the library for anti-idiotypic antibody screening, four anti-idiotypic nanobodies were selected and confirmed to be specific for anti-Cry1Ab mAb binding. Thereafter, a c-CLIA was developed for detection of Cry1Ab toxin based on anti-idiotypic camel nanobodies and employed for sample testing. The results revealed a half-inhibition concentration of developed assay to be 42.68 ± 2.54 ng/mL, in the linear range of 10.49-307.1 ng/mL. The established method is highly specific for Cry1Ab recognition, with negligible cross-reactivity for other Cry toxins. For spiked cereal samples, the recoveries of Cry1Ab toxin ranged from 77.4% to 127%, with coefficient of variation of less than 9%. This study demonstrated that the competitive format based on phage-displayed anti-idiotypic nanobodies can provide an alternative strategy for Cry toxin detection.
[Mh] Termos MeSH primário: Anticorpos Anti-Idiotípicos
Proteínas de Bactérias/análise
Bacteriófagos
Camelus/imunologia
Endotoxinas/análise
Proteínas Hemolisinas/análise
Medições Luminescentes/métodos
Anticorpos de Domínio Único
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais
Proteínas de Bactérias/imunologia
Camelus/sangue
Grãos Comestíveis/química
Endotoxinas/imunologia
Contaminação de Alimentos/análise
Proteínas Hemolisinas/imunologia
Linfócitos/química
Biblioteca de Peptídeos
RNA/isolamento & purificação
Anticorpos de Domínio Único/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Anti-Idiotypic); 0 (Antibodies, Monoclonal); 0 (Bacterial Proteins); 0 (Endotoxins); 0 (Hemolysin Proteins); 0 (Peptide Library); 0 (Single-Domain Antibodies); 0 (insecticidal crystal protein, Bacillus Thuringiensis); 63231-63-0 (RNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04923


  10 / 14643 MEDLINE  
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[PMID]:28988127
[Au] Autor:Solovieva EV; Myakinina VP; Kislichkina AA; Krasilnikova VM; Verevkin VV; Mochalov VV; Lev AI; Fursova NK; Volozhantsev NV
[Ad] Endereço:State Research Center for Applied Microbiology and Biotechnology, Obolensk 142279, Moscow Region, Russia.
[Ti] Título:Comparative genome analysis of novel Podoviruses lytic for hypermucoviscous Klebsiella pneumoniae of K1, K2, and K57 capsular types.
[So] Source:Virus Res;243:10-18, 2018 01 02.
[Is] ISSN:1872-7492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hypermucoviscous (HV) strains of capsular types K1, K2 and K57 are the most virulent representatives of the Klebsiella pneumoniae species. Eight novel bacteriophages lytic for HV K. pneumoniae were isolated and characterized. Three bacteriophages, KpV41, KpV475, and KpV71 were found to have a lytic activity against mainly K. pneumoniae of capsular type K1. Two phages, KpV74, and KpV763 were lytic for K2 capsular type K. pneumoniae, and the phage KpV767 was specific to K57-type K. pneumoniae only. Two more phages, KpV766, and KpV48 had no capsular specificity. The phage genomes consist of a linear double-stranded DNA of 40,395-44,623bp including direct terminal repeats of 180-246 bp. The G + C contents are 52.3-54.2 % that is slightly lower than that of genomes of K. pneumoniae strains being used for phage propagation. According to the genome structures, sequence similarity and phylogenetic data, the phages are classified within the genus Kp32virus and Kp34virus of subfamily Autographivirinae, family Podoviridae. In the phage genomes, genes encoding proteins with putative motifs of polysaccharide depolymerase were identified. Depolymerase genes of phages KpV71 and KpV74 lytic for hypermucoviscous K. pneumoniae of K1 and K2 capsular type, respectively, were cloned and expressed in Escherichia coli, and the recombinant gene products were purified. The specificity and polysaccharide-degrading activity of the recombinant depolymerases were demonstrated.
[Mh] Termos MeSH primário: Bacteriófagos/isolamento & purificação
Genoma Viral
Klebsiella pneumoniae/virologia
Podoviridae/isolamento & purificação
[Mh] Termos MeSH secundário: Cápsulas Bacterianas/genética
Cápsulas Bacterianas/metabolismo
Bacteriófagos/classificação
Bacteriófagos/genética
Ordem dos Genes
Klebsiella pneumoniae/genética
Klebsiella pneumoniae/metabolismo
Filogenia
Podoviridae/classificação
Podoviridae/genética
Proteínas Virais/genética
Proteínas Virais/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE



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