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Pesquisa : B04.123.470 [Categoria DeCS]
Referências encontradas : 39 [refinar]
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[PMID]:27383372
[Au] Autor:Diemer GS; Stedman KM
[Ad] Endereço:Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR, 97006, USA. diemer.g.phd@gmail.com.
[Ti] Título:Modeling Microvirus Capsid Protein Evolution Utilizing Metagenomic Sequence Data.
[So] Source:J Mol Evol;83(1-2):38-49, 2016 Aug.
[Is] ISSN:1432-1432
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The Microviridae are increasingly becoming recognized as one of the most globally ubiquitous and highly diverse virus families, and as such, provide an advantageous model for studying virus evolution and adaptation. Here, we utilize microvirus sequences from diverse physiochemical environments, including novel sequences from a high-temperature acidic lake, to chart the outcome of natural selection in the main structural protein of the virus. Each icosahedral microvirus virion is composed of sixty identical capsid proteins that interact along twofold, threefold and fivefold symmetry axis interfaces to encapsidate a small, circular, single-stranded DNA genome. Viable assembly of the virus is guided by scaffolding proteins, which coordinate inter-subunit contacts between the capsid proteins. Structure-based analysis indicates that amino acid sequence conservation is predominantly localized to the twofold axis interface. While preservation of this quaternary interface appears to be essential, tertiary and secondary structural features of the capsid protein are permissive to considerable sequence variation.
[Mh] Termos MeSH primário: Proteínas do Capsídeo/genética
Microvirus/genética
Análise de Sequência de DNA/métodos
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Capsídeo/fisiologia
DNA de Cadeia Simples
Evolução Molecular
Variação Genética
Microviridae/genética
Modelos Moleculares
Vírion/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (DNA, Single-Stranded)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE
[do] DOI:10.1007/s00239-016-9751-y


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[PMID]:27235779
[Au] Autor:Holmfeldt K; Solonenko N; Howard-Varona C; Moreno M; Malmstrom RR; Blow MJ; Sullivan MB
[Ad] Endereço:Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA.
[Ti] Título:Large-scale maps of variable infection efficiencies in aquatic Bacteroidetes phage-host model systems.
[So] Source:Environ Microbiol;18(11):3949-3961, 2016 Nov.
[Is] ISSN:1462-2920
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Microbes drive ecosystem functioning and their viruses modulate these impacts through mortality, gene transfer and metabolic reprogramming. Despite the importance of virus-host interactions and likely variable infection efficiencies of individual phages across hosts, such variability is seldom quantified. Here, we quantify infection efficiencies of 38 phages against 19 host strains in aquatic Cellulophaga (Bacteroidetes) phage-host model systems. Binary data revealed that some phages infected only one strain while others infected 17, whereas quantitative data revealed that efficiency of infection could vary 10 orders of magnitude, even among phages within one population. This provides a baseline for understanding and modeling intrapopulation host range variation. Genera specific host ranges were also informative. For example, the Cellulophaga Microviridae, showed a markedly broader intra-species host range than previously observed in Escherichia coli systems. Further, one phage genus, Cba41, was examined to investigate nonheritable changes in plating efficiency and burst size that depended on which host strain it most recently infected. While consistent with host modification of phage DNA, no differences in nucleotide sequence or DNA modifications were detected, leaving the observation repeatable, but the mechanism unresolved. Overall, this study highlights the importance of quantitatively considering replication variations in studies of phage-host interactions.
[Mh] Termos MeSH primário: Bacteriófagos/fisiologia
Bacteroidetes/virologia
Microviridae/fisiologia
[Mh] Termos MeSH secundário: Bacteriófagos/genética
Bacteroidetes/genética
Bacteroidetes/fisiologia
Replicação do DNA
Escherichia coli/fisiologia
Escherichia coli/virologia
Especificidade de Hospedeiro
Microviridae/genética
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160529
[St] Status:MEDLINE
[do] DOI:10.1111/1462-2920.13392


  3 / 39 MEDLINE  
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[PMID]:26874016
[Au] Autor:Doore SM; Fane BA
[Ad] Endereço:School of Plant Sciences and the BIO5 Institute University of Arizona, 1657 E. Helen Street, Tucson, AZ 85721, USA.
[Ti] Título:The microviridae: Diversity, assembly, and experimental evolution.
[So] Source:Virology;491:45-55, 2016 Apr.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Microviridae, comprised of ssDNA, icosahedral bacteriophages, are a model system for studying morphogenesis and the evolution of assembly. Historically limited to the φX174-like viruses, recent results demonstrate that this richly diverse family is broadly divided into two groups. The defining feature appears to be whether one or two scaffolding proteins are required for assembly. The single-scaffolding systems contain an internal scaffolding protein, similar to many dsDNA viruses, and have a more complex coat protein fold. The two-scaffolding protein systems (φX174-like) encode an internal and external species, as well as an additional structural protein: a spike on the icosahedral vertices. Here, we discuss recent in silico and in vivo evolutionary analyses conducted with chimeric viruses and/or chimeric proteins. The results suggest 1) how double scaffolding systems can evolve into single and triple scaffolding systems; and 2) how assembly is the critical factor governing adaptation and the maintenance of species boundaries.
[Mh] Termos MeSH primário: Evolução Biológica
Microviridae/fisiologia
Proteínas Virais/metabolismo
Montagem de Vírus
[Mh] Termos MeSH secundário: Biodiversidade
Microviridae/genética
Modelos Moleculares
Proteínas Virais/genética
Vírion/genética
Vírion/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; REVIEW
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160309
[Lr] Data última revisão:
160309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160214
[St] Status:MEDLINE


  4 / 39 MEDLINE  
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[PMID]:26319032
[Au] Autor:Brooks J; Watson AJ
[Ad] Endereço:Institute of Food Research and Norwich Medical School, University of East Anglia, Norwich, United Kingdom.
[Ti] Título:The Enteric Virome in Inflammatory Bowel Disease.
[So] Source:Gastroenterology;149(4):1120-1, 2015 Oct.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Caudovirales/isolamento & purificação
Colite Ulcerativa/virologia
Doença de Crohn/virologia
Disbiose/virologia
Microviridae/isolamento & purificação
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150926
[Lr] Data última revisão:
150926
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150831
[St] Status:MEDLINE


  5 / 39 MEDLINE  
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[PMID]:26242376
[Au] Autor:Shu P; Butt AM; Mi Z; Wang W; An X; Pei G; Zhang Z; Huang Y; Zhang X; Shi T; Tong Y
[Ad] Endereço:Anhui Medical University, Hefei, 230032, China.
[Ti] Título:Identification and genomic analysis of a novel member of Microviridae, IME-16, through high-throughput sequencing.
[So] Source:Virol Sin;30(4):301-4, 2015 Aug.
[Is] ISSN:1995-820X
[Cp] País de publicação:China
[La] Idioma:eng
[Mh] Termos MeSH primário: Genoma Viral
Microviridae/genética
Microviridae/isolamento & purificação
[Mh] Termos MeSH secundário: Análise por Conglomerados
DNA Viral/química
DNA Viral/genética
Ordem dos Genes
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Microviridae/classificação
Anotação de Sequência Molecular
Dados de Sequência Molecular
Fases de Leitura Aberta
Filogenia
Análise de Sequência de DNA
Homologia de Sequência
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150806
[St] Status:MEDLINE
[do] DOI:10.1007/s12250-015-3596-1


  6 / 39 MEDLINE  
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[PMID]:26226335
[Au] Autor:Zhong X; Guidoni B; Jacas L; Jacquet S
[Ad] Endereço:INRA, UMR CARRTEL, 75 Avenue de Corzent, 74203 Thonon-les-Bains, France.
[Ti] Título:Structure and diversity of ssDNA Microviridae viruses in two peri-alpine lakes (Annecy and Bourget, France).
[So] Source:Res Microbiol;166(8):644-54, 2015 Oct.
[Is] ISSN:1769-7123
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Microviridae is a subset of single-stranded DNA (ssDNA) viruses infecting bacteria. This group of phages has been previously observed to be very abundant (representing >90% of the total known viral metagenomic sequences) in Lake Bourget. However, this observation was made only during one period (in summer) and from a single sample collected at a single depth (near surface). This result suggests the importance of these viruses, poorly examined thus far, especially in fresh waters. In this study, performed on the two largest natural lakes in France (e.g. Lakes Annecy and Bourget), Microviridae structure was determined each month throughout the year (2011) using PCR-DGGE, with primers that target the major-capsid-protein-encoding gene VP1; cloning/sequencing was used to investigate their diversity. Our results confirm that Microviridae are diverse in peri-alpine lakes and are mainly represented by gokushoviruses. We also found for the first time ssDNA viruses belonging to Alpavirinae, another subfamily within Microviridae recently proposed by Krupovic and Forterre (2011), generally prophages infecting members of the Phylum Bacteroidetes. Our data also support highly variable community composition and dynamics of individual components whose patterns were different between lakes, suggesting distinct host communities and/or abiotic influences between the two ecosystems. We point out that most of the major observed ssDNA Microviridae viruses display boom-bust patterns (with a sharp increase/decline) in their dynamics, with high relative abundances, suggesting brutal control of hosts and rapid regulation of the host community structure.
[Mh] Termos MeSH primário: Lagos/virologia
Consórcios Microbianos
Microviridae/classificação
Microviridae/genética
Microbiologia da Água
[Mh] Termos MeSH secundário: Bacteroidetes/virologia
Proteínas do Capsídeo/genética
Ecossistema
França
Variação Genética
Microviridae/crescimento & desenvolvimento
Filogenia
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150924
[Lr] Data última revisão:
150924
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150731
[St] Status:MEDLINE


  7 / 39 MEDLINE  
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[PMID]:25841004
[Au] Autor:Reavy B; Swanson MM; Cock PJ; Dawson L; Freitag TE; Singh BK; Torrance L; Mushegian AR; Taliansky M
[Ad] Endereço:The James Hutton Institute, Dundee, Scotland, United Kingdom Brian.Reavy2@gmail.com Michael.Taliansky@hutton.ac.uk.
[Ti] Título:Distinct circular single-stranded DNA viruses exist in different soil types.
[So] Source:Appl Environ Microbiol;81(12):3934-45, 2015 Jun 15.
[Is] ISSN:1098-5336
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The potential dependence of virus populations on soil types was examined by electron microscopy, and the total abundance of virus particles in four soil types was similar to that previously observed in soil samples. The four soil types examined differed in the relative abundances of four morphological groups of viruses. Machair, a unique type of coastal soil in western Scotland and Ireland, differed from the others tested in having a higher proportion of tailed bacteriophages. The other soils examined contained predominantly spherical and thin filamentous virus particles, but the Machair soil had a more even distribution of the virus types. As the first step in looking at differences in populations in detail, virus sequences from Machair and brown earth (agricultural pasture) soils were examined by metagenomic sequencing after enriching for circular Rep-encoding single-stranded DNA (ssDNA) (CRESS-DNA) virus genomes. Sequences from the family Microviridae (icosahedral viruses mainly infecting bacteria) of CRESS-DNA viruses were predominant in both soils. Phylogenetic analysis of Microviridae major coat protein sequences from the Machair viruses showed that they spanned most of the diversity of the subfamily Gokushovirinae, whose members mainly infect obligate intracellular parasites. The brown earth soil had a higher proportion of sequences that matched the morphologically similar family Circoviridae in BLAST searches. However, analysis of putative replicase proteins that were similar to those of viruses in the Circoviridae showed that they are a novel clade of Circoviridae-related CRESS-DNA viruses distinct from known Circoviridae genera. Different soils have substantially different taxonomic biodiversities even within ssDNA viruses, which may be driven by physicochemical factors.
[Mh] Termos MeSH primário: Circoviridae/isolamento & purificação
Vírus de DNA/classificação
Vírus de DNA/isolamento & purificação
Microviridae/isolamento & purificação
Microbiologia do Solo
Solo/classificação
[Mh] Termos MeSH secundário: Sequência de Bases
Biodiversidade
Proteínas do Capsídeo/genética
Circoviridae/classificação
Circoviridae/genética
Vírus de DNA/genética
DNA de Cadeia Simples/genética
DNA Viral/genética
Genoma Viral
Irlanda
Metagenômica
Microviridae/classificação
Microviridae/genética
Filogenia
Escócia
Análise de Sequência de DNA
Vírion/classificação
Vírion/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (DNA, Single-Stranded); 0 (DNA, Viral); 0 (Soil)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150405
[St] Status:MEDLINE
[do] DOI:10.1128/AEM.03878-14


  8 / 39 MEDLINE  
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[PMID]:25666643
[Au] Autor:Ray K
[Ti] Título:IBD. Gut microbiota in IBD goes viral.
[So] Source:Nat Rev Gastroenterol Hepatol;12(3):122, 2015 Mar.
[Is] ISSN:1759-5053
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Caudovirales/isolamento & purificação
Colite Ulcerativa/virologia
Doença de Crohn/virologia
Disbiose/virologia
Microviridae/isolamento & purificação
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Em] Mês de entrada:1505
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150211
[St] Status:MEDLINE
[do] DOI:10.1038/nrgastro.2015.26


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[PMID]:25640518
[Au] Autor:Bryson SJ; Thurber AR; Correa AM; Orphan VJ; Vega Thurber R
[Ad] Endereço:Department of Microbiology, Oregon State University, 454 Nash Hall, Corvallis, OR, 97331, USA.
[Ti] Título:A novel sister clade to the enterobacteria microviruses (family Microviridae) identified in methane seep sediments.
[So] Source:Environ Microbiol;17(10):3708-21, 2015 Oct.
[Is] ISSN:1462-2920
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Methane seep microbial communities perform a key ecosystem service by consuming the greenhouse gas methane prior to its release into the hydrosphere, minimizing the impact of marine methane sources on our climate. Although previous studies have examined the ecology and biochemistry of these communities, none has examined viral assemblages associated with these habitats. We employed virus particle purification, genome amplification, pyrosequencing and gene/genome reconstruction and annotation on two metagenomic libraries, one prepared for ssDNA and the other for all DNA, to identify the viral community in a methane seep. Similarity analysis of these libraries (raw and assembled) revealed a community dominated by phages, with a significant proportion of similarities to the Microviridae family of ssDNA phages. We define these viruses as the Eel River Basin Microviridae (ERBM). Assembly and comparison of 21 ERBM closed circular genomes identified five as members of a novel sister clade to the Microvirus genus of Enterobacteria phages. Comparisons among other metagenomes and these Microviridae major-capsid sequences indicated that this clade of phages is currently unique to the Eel River Basin sediments. Given this ERBM clade's relationship to the Microviridae genus Microvirus, we define this sister clade as the candidate genus Pequeñovirus.
[Mh] Termos MeSH primário: Enterobacteriaceae/virologia
Sedimentos Geológicos/virologia
Microviridae/classificação
Microviridae/isolamento & purificação
[Mh] Termos MeSH secundário: Sequência de Bases
DNA Viral/genética
Ecossistema
Sedimentos Geológicos/microbiologia
Metagenoma
Metagenômica
Metano/metabolismo
Microviridae/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (DNA, Viral); OP0UW79H66 (Methane)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151022
[Lr] Data última revisão:
151022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150203
[St] Status:MEDLINE
[do] DOI:10.1111/1462-2920.12758


  10 / 39 MEDLINE  
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[PMID]:25619688
[Au] Autor:Norman JM; Handley SA; Baldridge MT; Droit L; Liu CY; Keller BC; Kambal A; Monaco CL; Zhao G; Fleshner P; Stappenbeck TS; McGovern DP; Keshavarzian A; Mutlu EA; Sauk J; Gevers D; Xavier RJ; Wang D; Parkes M; Virgin HW
[Ad] Endereço:Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
[Ti] Título:Disease-specific alterations in the enteric virome in inflammatory bowel disease.
[So] Source:Cell;160(3):447-60, 2015 Jan 29.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enriched for free virions in the intestine revealed that CD and UC were associated with a significant expansion of Caudovirales bacteriophages. The viromes of CD and UC patients were disease and cohort specific. Importantly, it did not appear that expansion and diversification of the enteric virome was secondary to changes in bacterial populations. These data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. We conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.
[Mh] Termos MeSH primário: Caudovirales/isolamento & purificação
Colite Ulcerativa/virologia
Doença de Crohn/virologia
Disbiose/virologia
Microviridae/isolamento & purificação
[Mh] Termos MeSH secundário: Bactérias/classificação
Bactérias/genética
Bactérias/isolamento & purificação
Estudos de Casos e Controles
Caudovirales/genética
Estudos de Coortes
Colite Ulcerativa/microbiologia
Colite Ulcerativa/patologia
Colite Ulcerativa/terapia
Doença de Crohn/microbiologia
Doença de Crohn/patologia
Doença de Crohn/terapia
Disbiose/microbiologia
Disbiose/patologia
Disbiose/terapia
Fezes/microbiologia
Fezes/virologia
Seres Humanos
Metagenoma
Microviridae/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Em] Mês de entrada:1504
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150127
[St] Status:MEDLINE



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