Base de dados : MEDLINE
Pesquisa : B04.123.660 [Categoria DeCS]
Referências encontradas : 367 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 37 ir para página                         

  1 / 367 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27776482
[Au] Autor:Wright RC; Brockhurst MA; Harrison E
[Ad] Endereço:Department of Biology, University of York, York, YO10 5DD, UK. rctw500@york.ac.uk.
[Ti] Título:Ecological conditions determine extinction risk in co-evolving bacteria-phage populations.
[So] Source:BMC Evol Biol;16(1):227, 2016 10 24.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antagonistic coevolution between bacteria and their viral parasites, phage, drives continual evolution of resistance and infectivity traits through recurrent cycles of adaptation and counter-adaptation. Both partners are vulnerable to extinction through failure of adaptation. Environmental conditions may impose unequal abiotic selection pressures on each partner, destabilising the coevolutionary relationship and increasing the extinction risk of one partner. In this study we explore how the degree of population mixing and resource supply affect coevolution-induced extinction risk by coevolving replicate populations of Pseudomonas fluorescens SBW25 with its associated lytic phage SBW25Ф2 under four treatment regimens incorporating low and high resource availability with mixed or static growth conditions. RESULTS: We observed an increased risk of phage extinction under population mixing, and in low resource conditions. High levels of evolved bacterial resistance promoted phage extinction at low resources under both mixed and static conditions, whereas phage populations could survive when phage susceptible bacterial genotypes rose to high frequency. CONCLUSIONS: These findings demonstrate that phage extinction risk is influenced by multiple abiotic conditions, which together act to destabilise the bacteria-phage coevolutionary relationship. The risk of coevolution-induced extinction is therefore dependent on the ecological context.
[Mh] Termos MeSH primário: Evolução Biológica
Ecologia
Extinção Biológica
Fagos de Pseudomonas/genética
Pseudomonas fluorescens/genética
Pseudomonas fluorescens/virologia
[Mh] Termos MeSH secundário: Genótipo
Fenótipo
Fatores de Risco
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180128
[Lr] Data última revisão:
180128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  2 / 367 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28964812
[Au] Autor:Jamal M; Andleeb S; Jalil F; Imran M; Nawaz MA; Hussain T; Ali M; Das CR
[Ad] Endereço:Department of Microbiology, Abdul Wali Khan University, Garden Campus, Mardan, Pakistan; Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), 44000 Islamabad, Pakistan; Emerging Pathogens Institute (EPI), University of Florida (UF), FL, USA. Ele
[Ti] Título:Isolation and characterization of a bacteriophage and its utilization against multi-drug resistant Pseudomonas aeruginosa-2995.
[So] Source:Life Sci;190:21-28, 2017 Dec 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: To identify, isolate, and characterize a lytic bacteriophage against the multiple-drug resistant clinical strain of Pseudomonas aeruginosa-2995 and to determine the phage efficacy against the bacterial planktonic cells and the biofilm. MAIN METHODS: Wastewater was used to isolate a bacteriophage. The phage was characterized with Transmission electron microscopy (TEM). Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS PAGE) was used to identify the expressed proteins. Bacteria were cultured in both suspension and biofilm to check and compare their susceptibility to phage lytic action. The activity of the phage (determined as AZ1) was determined against P. aeruginosa-2995 in both planktonic cells and the biofilm. KEY FINDINGS: A bacteriophage, designated as AZ1, was isolated from waste water showing a narrow host range. AZ1 was characterized by TEM and could be identified as an isolate in the family Siphoviridae [order Caudovirals]. Seventeen structural proteins ranging from about 12 to 110kDa were found through SDS-PAGE analysis. Its genome was confirmed as dsDNA with a length of approx. 50kb. The log-phase growth of P. aeruginosa-2995 was significantly reduced after treatment with AZ1 (4.50×10 to 2.1×10 CFU/ml) as compared to control. Furthermore, phage AZ1 significantly reduced 48h old biofilm biomass about 3-fold as compared to control. SIGNIFICANCE: Pseudomonas aeruginosa is a ubiquitous free-living opportunistic human pathogen characterized by high antibiotic tolerance and tendency for biofilm formation. The phage, identified in this study, AZ1, showed promising activity in the destruction of both planktonic cells and biofilm of P. aeruginosa-2995. However, complete eradication may require a combination of phages.
[Mh] Termos MeSH primário: Biofilmes
Fagos de Pseudomonas/fisiologia
Pseudomonas aeruginosa/virologia
Águas Residuais/virologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana Múltipla
Eletroforese em Gel de Poliacrilamida
Seres Humanos
Microscopia Eletrônica de Transmissão
Plâncton/microbiologia
Fagos de Pseudomonas/isolamento & purificação
Pseudomonas aeruginosa/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Waste Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


  3 / 367 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28877269
[Au] Autor:Magill DJ; Krylov VN; Shaburova OV; McGrath JW; Allen CCR; Quinn JP; Kulakov LA
[Ad] Endereço:Queen's University Belfast, School of Biological Sciences, Medical Biology Centre, Belfast, Northern Ireland.
[Ti] Título:Pf16 and phiPMW: Expanding the realm of Pseudomonas putida bacteriophages.
[So] Source:PLoS One;12(9):e0184307, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We present the analysis of two novel Pseudomonas putida phages, pf16 and phiPMW. Pf16 represents a peripherally related T4-like phage, and is the first of its kind infecting a Pseudomonad, with evidence suggesting cyanophage origins. Extensive divergence has resulted in pf16 occupying a newly defined clade designated as the pf16-related phages, lying at the interface of the Schizo T-Evens and Exo T-Evens. Recombination with an ancestor of the P. putida phage AF is likely responsible for the tropism of this phage. phiPMW represents a completely novel Pseudomonas phage with a genome containing substantial genetic novelty through its many hypothetical proteins. Evidence suggests that this phage has been extensively shaped through gene transfer events and vertical evolution. Phylogenetics shows that this phage has an evolutionary history involving FelixO1-related viruses but is in itself highly distinct from this group.
[Mh] Termos MeSH primário: Filogenia
Fagos de Pseudomonas/genética
Pseudomonas putida/virologia
[Mh] Termos MeSH secundário: Biofilmes
Proteínas do Capsídeo/genética
Análise por Conglomerados
Biologia Computacional
Biblioteca Gênica
Técnicas de Transferência de Genes
Genoma Bacteriano
Genoma Viral
Mutação
Regiões Promotoras Genéticas
Recombinação Genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184307


  4 / 367 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28771128
[Au] Autor:Pourcel C; Midoux C; Vergnaud G; Latino L
[Ad] Endereço:Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
[Ti] Título:A carrier state is established in Pseudomonas aeruginosa by phage LeviOr01, a newly isolated ssRNA levivirus.
[So] Source:J Gen Virol;98(8):2181-2189, 2017 Aug.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:ssRNA bacteriophages are very abundant but poorly studied, particularly in relation to their effect on bacterial evolution. We isolated a new Pseudomonas aeruginosa levivirus, vB_PaeL_PcyII-10_LeviOr01, from hospital waste water. Its genome comprises 3669 nucleotides and encodes four putative proteins. Following bacterial infection, a carrier state is established in a fraction of the cells, conferring superinfection immunity. Such cells also resist other phages that use type IV pili as a receptor. The carrier population is composed of a mixture of cells producing phage, and susceptible cells that are non-carriers. Carrier cells accumulate phage until they burst, releasing large quantities of virions. The continuous presence of phage favours the emergence of host variants bearing mutations in genes involved in type IV pilus biogenesis, but also in genes affecting lipopolysaccharide (LPS) synthesis. The establishment of a carrier state in which phage particles are continuously released was previously reported for some dsRNA phages, but has not previously been described for a levivirus. The present results highlight the importance of the carrier state, an association that benefits both phages and bacteria and plays a role in bacterial evolution.
[Mh] Termos MeSH primário: Interações Hospedeiro-Parasita
Levivirus/fisiologia
Fagos de Pseudomonas/fisiologia
Pseudomonas aeruginosa/virologia
[Mh] Termos MeSH secundário: Genoma Viral
Levivirus/isolamento & purificação
Fagos de Pseudomonas/isolamento & purificação
RNA Viral/genética
Análise de Sequência de DNA
Liberação de Vírus
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000883


  5 / 367 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28649138
[Au] Autor:De Smet J; Hendrix H; Blasdel BG; Danis-Wlodarczyk K; Lavigne R
[Ad] Endereço:Laboratory of Gene Technology, Department of Biosystems, KU Leuven, Kasteelpark Arenberg 21, Box 2462, 3001 Heverlee, Belgium.
[Ti] Título:Pseudomonas predators: understanding and exploiting phage-host interactions.
[So] Source:Nat Rev Microbiol;15(9):517-530, 2017 Sep.
[Is] ISSN:1740-1534
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Species in the genus Pseudomonas thrive in a diverse set of ecological niches and include crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant pathogen Pseudomonas syringae. The bacteriophages that infect Pseudomonas spp. mirror the widespread and diverse nature of their hosts. Therefore, Pseudomonas spp. and their phages are an ideal system to study the molecular mechanisms that govern virus-host interactions. Furthermore, phages are principal catalysts of host evolution and diversity, which directly affects the ecological roles of environmental and pathogenic Pseudomonas spp. Understanding these interactions not only provides novel insights into phage biology but also advances the development of phage therapy, phage-derived antimicrobial strategies and innovative biotechnological tools that may be derived from phage-bacteria interactions.
[Mh] Termos MeSH primário: Interações Hospedeiro-Patógeno/genética
Fagos de Pseudomonas/crescimento & desenvolvimento
Fagos de Pseudomonas/genética
Pseudomonas/genética
Pseudomonas/virologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1038/nrmicro.2017.61


  6 / 367 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28622385
[Au] Autor:Secor PR; Sass G; Nazik H; Stevens DA
[Ad] Endereço:Department of Microbiology, University of Washington, Seattle, Washington, United States of America.
[Ti] Título:Effect of acute predation with bacteriophage on intermicrobial aggression by Pseudomonas aeruginosa.
[So] Source:PLoS One;12(6):e0179659, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In persons with structural lung disease, particularly those with cystic fibrosis (CF), chronic airway infections cause progressive loss of lung function. CF airways can be colonized by a variety of microorganisms; the most frequently encountered bacterial and fungal pathogens are Pseudomonas aeruginosa and Aspergillus fumigatus, respectively. Co-infection with P. aeruginosa and A. fumigatus often results in a more rapid loss of lung function, indicating that interactions between these pathogens affect infection pathogenesis. There has been renewed interest in the use of viruses (bacteriophage, mycoviruses) as alternatives to antibiotics to treat these infections. In previous work, we found that filamentous Pf bacteriophage produced by P. aeruginosa directly inhibited the metabolic activity of A. fumigatus by binding to and sequestering iron. In the current study, we further examined how filamentous Pf bacteriophage affected interactions between P. aeruginosa and A. fumigatus. Here, we report that the antifungal properties of supernatants collected from P. aeruginosa cultures infected with Pf bacteriophage were substantially less inhibitory towards A. fumigatus biofilms. In particular, we found that acute infection of P. aeruginosa by Pf bacteriophage inhibited the production of the virulence factor pyoverdine. Our results raise the possibility that the reduced production of antimicrobials by P. aeruginosa infected by Pf bacteriophage may promote conditions in CF airways that allow co-infection with A. fumigatus to occur, exacerbating disease severity. Our results also highlight the importance of considering how the use of bacteriophage as therapeutic agents could affect the behavior and composition of polymicrobial communities colonizing sites of chronic infection.
[Mh] Termos MeSH primário: Aspergillus fumigatus/fisiologia
Biofilmes/crescimento & desenvolvimento
Fagos de Pseudomonas/crescimento & desenvolvimento
Pseudomonas aeruginosa
[Mh] Termos MeSH secundário: Coinfecção/metabolismo
Coinfecção/microbiologia
Fibrose Cística/metabolismo
Fibrose Cística/microbiologia
Seres Humanos
Pseudomonas aeruginosa/fisiologia
Pseudomonas aeruginosa/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179659


  7 / 367 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28472930
[Au] Autor:Amgarten D; Martins LF; Lombardi KC; Antunes LP; de Souza APS; Nicastro GG; Kitajima EW; Quaggio RB; Upton C; Setubal JC; da Silva AM
[Ad] Endereço:Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
[Ti] Título:Three novel Pseudomonas phages isolated from composting provide insights into the evolution and diversity of tailed phages.
[So] Source:BMC Genomics;18(1):346, 2017 05 04.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Among viruses, bacteriophages are a group of special interest due to their capacity of infecting bacteria that are important for biotechnology and human health. Composting is a microbial-driven process in which complex organic matter is converted into humus-like substances. In thermophilic composting, the degradation activity is carried out primarily by bacteria and little is known about the presence and role of bacteriophages in this process. RESULTS: Using Pseudomonas aeruginosa as host, we isolated three new phages from a composting operation at the Sao Paulo Zoo Park (Brazil). One of the isolated phages is similar to Pseudomonas phage Ab18 and belongs to the Siphoviridae YuA-like viral genus. The other two isolated phages are similar to each other and present genomes sharing low similarity with phage genomes in public databases; we therefore hypothesize that they belong to a new genus in the Podoviridae family. Detailed genomic descriptions and comparisons of the three phages are presented, as well as two new clusters of phage genomes in the Viral Orthologous Clusters database of large DNA viruses. We found sequences encoding homing endonucleases that disrupt a putative ribonucleotide reductase gene and an RNA polymerase subunit 2 gene in two of the phages. These findings provide insights about the evolution of two-subunits RNA polymerases and the possible role of homing endonucleases in this process. Infection tests on 30 different strains of bacteria reveal a narrow host range for the three phages, restricted to P. aeruginosa PA14 and three other P. aeruginosa clinical isolates. Biofilm dissolution assays suggest that these phages could be promising antimicrobial agents against P. aeruginosa PA14 infections. Analyses on composting metagenomic and metatranscriptomic data indicate association between abundance variations in both phage and host populations in the environment. CONCLUSION: The results about the newly discovered and described phages contribute to the understanding of tailed bacteriophage diversity, evolution, and role in the complex composting environment.
[Mh] Termos MeSH primário: Genoma Viral
Fagos de Pseudomonas/genética
[Mh] Termos MeSH secundário: Sequência de Bases
Biofilmes
Códon
Sequência Conservada
Endodesoxirribonucleases/genética
Evolução Molecular
Variação Genética
Mutagênese Insercional
Filogenia
Fagos de Pseudomonas/isolamento & purificação
Fagos de Pseudomonas/ultraestrutura
Pseudomonas aeruginosa/crescimento & desenvolvimento
Pseudomonas aeruginosa/virologia
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Análise de Sequência de DNA
Solo
Microbiologia do Solo
Transcriptoma
Proteínas Virais/genética
Proteínas Virais/metabolismo
Tropismo Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Codon); 0 (RNA, Messenger); 0 (Soil); 0 (Viral Proteins); EC 3.1.- (Endodeoxyribonucleases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE
[do] DOI:10.1186/s12864-017-3729-z


  8 / 367 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28418081
[Au] Autor:Shafique M; Alvi IA; Abbas Z; Ur Rehman S
[Ad] Endereço:Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.
[Ti] Título:Assessment of biofilm removal capacity of a broad host range bacteriophage JHP against Pseudomonas aeruginosa.
[So] Source:APMIS;125(6):579-584, 2017 Jun.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Pseudomonas aeruginosa is an efficient biofilm-dwelling microbial pathogen, associated with nosocomial infections. These biofilm-associated infections are resistant to antibiotics and immune defenses, therefore pose major problem against their treatment. This scenario demands alternative therapeutic regimens, and bacteriophage therapy is one among potential strategies for clinical management of multiple drug resistance. In this investigation, the efficacy of a bacteriophage, JHP, is evaluated to eradicate P. aeruginosa biofilms. Growth kinetics of P. aeruginosa biofilm revealed that the highest cell density biofilm (1.5 × 10 CFU/mL) was established within the polystyrene microtiter plate at 72 h post inoculation. Pseudomonas aeruginosa biofilms of different ages, treated with JHP (0.6 MOI) for different post-infection durations, reduced biomass from 2 to 4.5 logs (60-90%). JHP treatment before biofilm development reduced the bacterial load up to 9 logs (>95% bacterial load reduction) as compared with untreated control, which highlights its potential to prevent biofilm formation in indwelling medical devices. Combinations of JHP with other phages or antibiotics could be an efficient alternative for P. aeruginosa biofilm removal in clinical and industrial settings.
[Mh] Termos MeSH primário: Biofilmes/crescimento & desenvolvimento
Fagos de Pseudomonas/fisiologia
Pseudomonas aeruginosa/fisiologia
Pseudomonas aeruginosa/virologia
[Mh] Termos MeSH secundário: Contagem de Colônia Microbiana
Especificidade de Hospedeiro
Viabilidade Microbiana
Fagos de Pseudomonas/crescimento & desenvolvimento
Pseudomonas aeruginosa/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12691


  9 / 367 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28082593
[Au] Autor:Chaikeeratisak V; Nguyen K; Khanna K; Brilot AF; Erb ML; Coker JK; Vavilina A; Newton GL; Buschauer R; Pogliano K; Villa E; Agard DA; Pogliano J
[Ad] Endereço:Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
[Ti] Título:Assembly of a nucleus-like structure during viral replication in bacteria.
[So] Source:Science;355(6321):194-197, 2017 01 13.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We observed the assembly of a nucleus-like structure in bacteria during viral infection. Using fluorescence microscopy and cryo-electron tomography, we showed that Pseudomonas chlororaphis phage 201φ2-1 assembled a compartment that separated viral DNA from the cytoplasm. The phage compartment was centered by a bipolar tubulin-based spindle, and it segregated phage and bacterial proteins according to function. Proteins involved in DNA replication and transcription localized inside the compartment, whereas proteins involved in translation and nucleotide synthesis localized outside. Later during infection, viral capsids assembled on the cytoplasmic membrane and moved to the surface of the compartment for DNA packaging. Ultimately, viral particles were released from the compartment and the cell lysed. These results demonstrate that phages have evolved a specialized structure to compartmentalize viral replication.
[Mh] Termos MeSH primário: Fagos de Pseudomonas/fisiologia
Pseudomonas chlororaphis/virologia
Montagem de Vírus
[Mh] Termos MeSH secundário: Capsídeo/metabolismo
Proteínas do Capsídeo/biossíntese
Proteínas do Capsídeo/genética
Microscopia Crioeletrônica
Citoplasma/ultraestrutura
Citoplasma/virologia
DNA Viral/biossíntese
Microscopia de Fluorescência
Fagos de Pseudomonas/genética
Pseudomonas chlororaphis/ultraestrutura
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (DNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1126/science.aal2130


  10 / 367 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28076419
[Au] Autor:Zhao XF; Hao YQ; Zhang QG
[Ad] Endereço:State Key Laboratory of Earth Surface Processes and Resource Ecology and MOE Key Laboratory for Biodiversity Science and Ecological Engineering, Beijing Normal University, Beijing, China.
[Ti] Título:Stability of A Coevolving Host-parasite System Peaks at Intermediate Productivity.
[So] Source:PLoS One;12(1):e0168560, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Habitat productivity may affect the stability of consumer-resource systems, through both ecological and evolutionary mechanisms. We hypothesize that coevolving consumer-resource systems show more stable dynamics at intermediate resource availability, while very low-level resource supply cannot support sufficiently large populations of resource and consumer species to avoid stochastic extinction, and extremely resource-rich environments may promote escalatory arms-race-like coevolution that can cause strong fluctuations in species abundance and even extinction of one or both trophic levels. We tested these ideas by carrying out an experimental evolution study with a model bacterium-phage system (Pseudomonas fluorescens SBW25 and its phage SBW25Φ2). Consistent with our hypothesis, this system was most stable at intermediate resource supply (fewer extinction events and smaller magnitude of population fluctuation). In our experiment, the rate of coevolution between bacterial resistance and phage infectivity was correlated with the magnitude of population fluctuation, which may explain the different in stability between levels of resource supply. Crucially, our results are consistent with a suggestion that, among the two major modes of antagonistic coevolution, arms race is more likely than fluctuation selection dynamics to cause extinction events in consumer-resource systems. This study suggests an important role of environment-dependent coevolutionary dynamics for the stability of consumer-resource species systems, therefore highlights the importance to consider contemporaneous evolutionary dynamics when studying the stability of ecosystems, particularly those under environmental changes.
[Mh] Termos MeSH primário: Evolução Molecular
Interações Hospedeiro-Patógeno/fisiologia
Modelos Biológicos
Fagos de Pseudomonas/fisiologia
Pseudomonas fluorescens/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0168560



página 1 de 37 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde