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Pesquisa : B04.265.658 [Categoria DeCS]
Referências encontradas : 444 [refinar]
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[PMID]:28825206
[Au] Autor:Costa TM; Blawid R; da Costa Junior AC; Lima MF; de Aragão FAS; de Andrade GP; Pio-Ribeiro G; Aranda MA; Inoue-Nagata AK; Nagata T
[Ad] Endereço:Departmento de Biologia Celular, Universidade de Brasília, Brasília, DF, 70910-900, Brazil.
[Ti] Título:Complete genome sequence of melon yellowing-associated virus from melon plants with the severe yellowing disease in Brazil.
[So] Source:Arch Virol;162(12):3899-3901, 2017 Dec.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Here, we describe the complete genome sequence of melon yellowing-associated virus (MYaV), found in melon plants with severe yellowing disease, determined by high-throughput and Sanger sequencing. MYaV has an RNA genome of 9073 nucleotides plus a poly(A) tail. At least six open reading frames were predicted, with a typical carlavirus genomic organisation. Phylogenetic analysis of the complete genome sequence and the amino acid sequences of the RNA-dependent RNA polymerase confirmed that MYaV belongs to the genus Carlavirus, with the highest genome-wide nucleotide sequence identity of 59.8% to sweet potato yellow mottle virus.
[Mh] Termos MeSH primário: Carlavirus/classificação
Carlavirus/isolamento & purificação
Cucurbitaceae/virologia
Genoma Viral
Doenças das Plantas/virologia
Análise de Sequência de DNA
[Mh] Termos MeSH secundário: Brasil
Carlavirus/genética
Fases de Leitura Aberta
Filogenia
RNA Viral/genética
Vírus Satélites
Homologia de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3532-9


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[PMID]:27900540
[Au] Autor:Mollel HG; Ndunguru J; Sseruwagi P; Alicai T; Colvin J; Navas-Castillo J; Fiallo-Olivé E
[Ad] Endereço:Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga - Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Estación Experimental "La Mayora", 29750, Algarrobo-Costa, Málaga, Spain.
[Ti] Título:A novel East African monopartite begomovirus-betasatellite complex that infects Vernonia amygdalina.
[So] Source:Arch Virol;162(4):1079-1082, 2017 Apr.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:The complete genomes of a monopartite begomovirus (genus Begomovirus, family Geminiviridae) and an associated betasatellite found infecting Vernonia amygdalina Delile (family Compositae) in Uganda were cloned and sequenced. Begomoviruses isolated from two samples showed the highest nucleotide sequence identity (73.1% and 73.2%) to an isolate of the monopartite begomovirus tomato leaf curl Vietnam virus, and betasatellites from the same samples exhibited the highest nucleotide sequence identity (67.1% and 68.2%) to vernonia yellow vein Fujian betasatellite. Following the current taxonomic criteria for begomovirus species demarcation, the isolates sequenced here represent a novel begomovirus species. Based on symptoms observed in the field, we propose the name vernonia crinkle virus (VeCrV) for this novel begomovirus and vernonia crinkle betasatellite (VeCrB) for the associated betasatellite. This is the first report of a monopartite begomovirus-betasatellite complex from Uganda.
[Mh] Termos MeSH primário: Begomovirus/isolamento & purificação
Doenças das Plantas/virologia
Vírus Satélites/isolamento & purificação
Vernonia/virologia
[Mh] Termos MeSH secundário: Begomovirus/classificação
Begomovirus/genética
DNA Viral/genética
Genoma Viral
Filogenia
Vírus Satélites/classificação
Vírus Satélites/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-016-3175-2


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[PMID]:27387973
[Au] Autor:Dziewit L; Radlinska M
[Ad] Endereço:Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland.
[Ti] Título:Two Inducible Prophages of an Antarctic Pseudomonas sp. ANT_H14 Use the Same Capsid for Packaging Their Genomes - Characterization of a Novel Phage Helper-Satellite System.
[So] Source:PLoS One;11(7):e0158889, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two novel prophages ФAH14a and ФAH14b of a psychrotolerant Antarctic bacterium Pseudomonas sp. ANT_H14 have been characterized. They were simultaneously induced with mitomycin C and packed into capsids of the same size and protein composition. The genome sequences of ФAH14a and ФAH14b have been determined. ФAH14b, the phage with a smaller genome (16,812 bp) seems to parasitize ФAH14a (55,060 bp) and utilizes its capsids, as only the latter encodes a complete set of structural proteins. Both viruses probably constitute a phage helper-satellite system, analogous to the P2-P4 duo. This study describes the architecture and function of the ФAH14a and ФAH14b genomes. Moreover, a functional analysis of a ФAH14a-encoded lytic enzyme and a DNA methyltransferase was performed. In silico analysis revealed the presence of the homologs of ФAH14a and ФAH14b in other Pseudomonas genomes, which may suggest that helper-satellite systems related to the one described in this work are common in pseudomonads.
[Mh] Termos MeSH primário: Bacteriófagos/genética
Prófagos/genética
Pseudomonas/virologia
Vírus Satélites/genética
[Mh] Termos MeSH secundário: Regiões Antárticas
Capsídeo/metabolismo
Proteínas do Capsídeo/genética
DNA (Citosina-5-)-Metiltransferases/genética
Análise Mutacional de DNA
DNA Viral/metabolismo
Regulação Viral da Expressão Gênica
Genes Virais
Vírus Auxiliares/genética
Microbiologia do Solo
Ativação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (DNA, Viral); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0158889


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[PMID]:27084243
[Au] Autor:Nosaka N; Hatayama K; Fujii Y; Yashiro M; Tsukahara H; Morishima T
[Ad] Endereço:Department of Pediatrics, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama city 700-8558, Japan. Electronic address: pv702xz5@s.okayama-u.ac.jp.
[Ti] Título:Letter to the Editor regarding the paper by Sun G et al: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neuro Sci 2015;349:190-195.
[So] Source:J Neurol Sci;364:188, 2016 May 15.
[Is] ISSN:1878-5883
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Elastase de Leucócito/sangue
Vírus Satélites
[Mh] Termos MeSH secundário: Encefalopatias
Seres Humanos
Orthomyxoviridae
[Pt] Tipo de publicação:COMMENT; LETTER
[Nm] Nome de substância:
EC 3.4.21.37 (Leukocyte Elastase)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160416
[Lr] Data última revisão:
160416
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160417
[St] Status:MEDLINE


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[PMID]:27041156
[Au] Autor:Ishiguro T; Takayanagi N; Kanauchi T; Uozumi R; Kawate E; Takaku Y; Kagiyama N; Shimizu Y; Hoshi T; Morita S; Sugita Y
[Ad] Endereço:Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.
[Ti] Título:Clinical and Radiographic Comparison of Influenza Virus-associated Pneumonia among Three Viral Subtypes.
[So] Source:Intern Med;55(7):731-7, 2016.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Presently, the predominant subtypes of influenza viruses in the world, except for those in local epidemics, include influenza pandemic H1N1 2009 (pH1N1), H3N2, and B viruses. There are few reports on the differences in the clinical features, radiographic findings, treatment, and outcomes of influenza virus-associated pneumonia among these three viral subtypes. The purpose of this study was to investigate whether the clinical features, radiographic findings, treatment, and outcomes differ among the viral subtypes. METHODS: We retrospectively analyzed 96 patients with influenza virus-associated pneumonia whose viral subtypes were clarified. RESULTS: Patients with pH1N1 virus-associated pneumonia tended to be young. The frequency of primary viral pneumonia differed among the virus-associated pneumonia subtypes (pH1N1, 80%; H3N2, 26.5%; and B, 31%). Patients with pH1N1 virus-associated pneumonia more frequently showed bilateral ground-glass opacities (GGOs), which affected more lobes than in patients with H3N2 and B virus-associated pneumonia. However, patients with H3N2 virus-associated pneumonia showed a higher frequency of consolidation and diffuse bronchial wall thickening than did the patients with pH1N1 virus-associated pneumonia. The severity and mortality did not differ among the three pneumonia subtypes. CONCLUSION: In the patients who developed influenza virus-associated pneumonia, those with pH1N1 virus-associated pneumonia frequently developed primary viral pneumonia resulting in bilateral and broad areas of GGOs on imaging, whereas patients with H3N2 virus-associated pneumonia frequently showed consolidation and diffuse bronchial wall thickening on pulmonary imaging.
[Mh] Termos MeSH primário: Vírus da Influenza A Subtipo H1N1
Vírus da Influenza A Subtipo H3N2
Vírus da Influenza B
Influenza Humana/virologia
Pulmão/diagnóstico por imagem
Pneumonia Viral/virologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Vírus da Influenza A Subtipo H1N1/isolamento & purificação
Vírus da Influenza A Subtipo H3N2/isolamento & purificação
Vírus da Influenza B/isolamento & purificação
Influenza Humana/complicações
Influenza Humana/diagnóstico por imagem
Influenza Humana/fisiopatologia
Influenza Humana/terapia
Pulmão/fisiopatologia
Pulmão/virologia
Masculino
Meia-Idade
Pneumonia Viral/diagnóstico por imagem
Pneumonia Viral/fisiopatologia
Pneumonia Viral/terapia
Radiografia Torácica
Estudos Retrospectivos
Vírus Satélites
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE
[do] DOI:10.2169/internalmedicine.55.5227


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[PMID]:26884209
[Au] Autor:Smith TL; Yuan Z; Cardó-Vila M; Sanchez Claros C; Adem A; Cui MH; Branch CA; Gelovani JG; Libutti SK; Sidman RL; Pasqualini R; Arap W
[Ad] Endereço:University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87131; Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131;
[Ti] Título:AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas.
[So] Source:Proc Natl Acad Sci U S A;113(9):2466-71, 2016 Mar 01.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patients with inoperable or unresectable pancreatic neuroendocrine tumors (NETs) have limited treatment options. These rare human tumors often express somatostatin receptors (SSTRs) and thus are clinically responsive to certain relatively stable somatostatin analogs, such as octreotide. Unfortunately, however, this tumor response is generally short-lived. Here we designed a hybrid adeno-associated virus and phage (AAVP) vector displaying biologically active octreotide on the viral surface for ligand-directed delivery, cell internalization, and transduction of an apoptosis-promoting tumor necrosis factor (TNF) transgene specifically to NETs. These functional attributes of AAVP-TNF particles displaying the octreotide peptide motif (termed Oct-AAVP-TNF) were confirmed in vitro, in SSTR type 2-expressing NET cells, and in vivo using cohorts of pancreatic NET-bearing Men1 tumor-suppressor gene KO mice, a transgenic model of functioning (i.e., insulin-secreting) tumors that genetically and clinically recapitulates the human disease. Finally, preclinical imaging and therapeutic experiments with pancreatic NET-bearing mice demonstrated that Oct-AAVP-TNF lowered tumor metabolism and insulin secretion, reduced tumor size, and improved mouse survival. Taken together, these proof-of-concept results establish Oct-AAVP-TNF as a strong therapeutic candidate for patients with NETs of the pancreas. More broadly, the demonstration that a known, short, biologically active motif can direct tumor targeting and receptor-mediated internalization of AAVP particles may streamline the potential utility of myriad other short peptide motifs and provide a blueprint for therapeutic applications in a variety of cancers and perhaps many nonmalignant diseases as well.
[Mh] Termos MeSH primário: Bacteriófagos/genética
Dependovirus/genética
Dependovirus/metabolismo
Vetores Genéticos
Tumores Neuroendócrinos/terapia
Octreotida/administração & dosagem
Neoplasias Pancreáticas/terapia
Vírus Satélites/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Ligantes
Masculino
Camundongos
Camundongos Transgênicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ligands); RWM8CCW8GP (Octreotide)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160218
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1525709113


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[PMID]:26848679
[Au] Autor:Rosario K; Marr C; Varsani A; Kraberger S; Stainton D; Moriones E; Polston JE; Breitbart M
[Ad] Endereço:College of Marine Science, University of South Florida, Saint Petersburg, FL 33701, USA. krosari2@mail.usf.edu.
[Ti] Título:Begomovirus-Associated Satellite DNA Diversity Captured Through Vector-Enabled Metagenomic (VEM) Surveys Using Whiteflies (Aleyrodidae).
[So] Source:Viruses;8(2), 2016 Feb 02.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Monopartite begomoviruses (Geminiviridae), which are whitefly-transmitted single-stranded DNA viruses known for causing devastating crop diseases, are often associated with satellite DNAs. Since begomovirus acquisition or exchange of satellite DNAs may lead to adaptation to new plant hosts and emergence of new disease complexes, it is important to investigate the diversity and distribution of these molecules. This study reports begomovirus-associated satellite DNAs identified during a vector-enabled metagenomic (VEM) survey of begomoviruses using whiteflies collected in various locations (California (USA), Guatemala, Israel, Puerto Rico, and Spain). Protein-encoding satellite DNAs, including alphasatellites and betasatellites, were identified in Israel, Puerto Rico, and Guatemala. Novel alphasatellites were detected in samples from Guatemala and Puerto Rico, resulting in the description of a phylogenetic clade (DNA-3-type alphasatellites) dominated by New World sequences. In addition, a diversity of small (~640-750 nucleotides) satellite DNAs similar to satellites associated with begomoviruses infecting Ipomoea spp. were detected in Puerto Rico and Spain. A third class of satellite molecules, named gammasatellites, is proposed to encompass the increasing number of reported small (<1 kilobase), non-coding begomovirus-associated satellite DNAs. This VEM-based survey indicates that, although recently recovered begomovirus genomes are variations of known genetic themes, satellite DNAs hold unexplored genetic diversity.
[Mh] Termos MeSH primário: Begomovirus/genética
DNA Satélite/genética
DNA Viral/genética
Hemípteros/virologia
Insetos Vetores/virologia
Vírus Satélites/genética
[Mh] Termos MeSH secundário: Animais
Begomovirus/metabolismo
DNA Satélite/metabolismo
DNA Viral/metabolismo
Variação Genética
Hemípteros/classificação
Metagenômica
Dados de Sequência Molecular
Filogenia
Doenças das Plantas/virologia
Vírus Satélites/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (DNA, Satellite); 0 (DNA, Viral)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160206
[St] Status:MEDLINE


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[PMID]:26551994
[Au] Autor:Palukaitis P
[Ad] Endereço:Department of Horticultural Sciences, Seoul Women's University, 621 Hwarangno, Nowon-gu, Seoul, 139-774, Republic of Korea.
[Ti] Título:Satellite RNAs and Satellite Viruses.
[So] Source:Mol Plant Microbe Interact;29(3):181-6, 2016 Mar.
[Is] ISSN:0894-0282
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Satellite RNAs and satellite viruses are extraviral components that can affect either the pathogenicity, the accumulation, or both of their associated viruses while themselves being dependent on the associated viruses as helper viruses for their infection. Most of these satellite RNAs are noncoding RNAs, and in many cases, have been shown to alter the interaction of their helper viruses with their hosts. In only a few cases have the functions of these satellite RNAs in such interactions been studied in detail. In particular, work on the satellite RNAs of Cucumber mosaic virus and Turnip crinkle virus have provided novel insights into RNAs functioning as noncoding RNAs. These effects are described and potential roles for satellite RNAs in the processes involved in symptom intensification or attenuation are discussed. In most cases, models describing these roles involve some aspect of RNA silencing or its suppression, either directly or indirectly involving the particular satellite RNA.
[Mh] Termos MeSH primário: Satélite do Vírus do Mosaico do Pepino/genética
Cucumovirus/genética
RNA Satélite
Vírus Satélites/fisiologia
[Mh] Termos MeSH secundário: Regulação Viral da Expressão Gênica/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Cucumber Mosaic Virus Satellite); 0 (RNA, Satellite)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160319
[Lr] Data última revisão:
160319
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151110
[St] Status:MEDLINE
[do] DOI:10.1094/MPMI-10-15-0232-FI


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[PMID]:26446887
[Au] Autor:Krupovic M; Kuhn JH; Fischer MG
[Ad] Endereço:Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Institut Pasteur, Paris, France. krupovic@pasteur.fr.
[Ti] Título:A classification system for virophages and satellite viruses.
[So] Source:Arch Virol;161(1):233-47, 2016 Jan.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Satellite viruses encode structural proteins required for the formation of infectious particles but depend on helper viruses for completing their replication cycles. Because of this unique property, satellite viruses that infect plants, arthropods, or mammals, as well as the more recently discovered satellite-like viruses that infect protists (virophages), have been grouped with other, so-called "sub-viral agents." For the most part, satellite viruses are therefore not classified. We argue that possession of a coat-protein-encoding gene and the ability to form virions are the defining features of a bona fide virus. Accordingly, all satellite viruses and virophages should be consistently classified within appropriate taxa. We propose to create four new genera - Albetovirus, Aumaivirus, Papanivirus, and Virtovirus - for positive-sense single-stranded (+) RNA satellite viruses that infect plants and the family Sarthroviridae, including the genus Macronovirus, for (+)RNA satellite viruses that infect arthopods. For double-stranded DNA virophages, we propose to establish the family Lavidaviridae, including two genera, Sputnikvirus and Mavirus.
[Mh] Termos MeSH primário: Doenças dos Animais/virologia
Classificação/métodos
Doenças das Plantas/virologia
Vírus Satélites/classificação
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Genoma Viral
Dados de Sequência Molecular
Filogenia
RNA Satélite/genética
Vírus Satélites/genética
Vírus Satélites/isolamento & purificação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Satellite)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160104
[Lr] Data última revisão:
160104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151009
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-015-2622-9


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[PMID]:26524912
[Au] Autor:Gong C; Zhou X; Pan Y; Wang Y
[Ti] Título:[Prediction of Promoter Motifs in Virophages].
[So] Source:Bing Du Xue Bao;31(4):395-403, 2015 Jul.
[Is] ISSN:1000-8721
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Virophages have crucial roles in ecosystems and are the transport vectors of genetic materials. To shed light on regulation and control mechanisms in virophage--host systems as well as evolution between virophages and their hosts, the promoter motifs of virophages were predicted on the upstream regions of start codons using an analytical tool for prediction of promoter motifs: Multiple EM for Motif Elicitation. Seventeen potential promoter motifs were identified based on the E-value, location, number and length of promoters in genomes. Sputnik and zamilon motif 2 with AT-rich regions were distributed widely on genomes, suggesting that these motifs may be associated with regulation of the expression of various genes. Motifs containing the TCTA box were predicted to be late promoter motif in mavirus; motifs containing the ATCT box were the potential late promoter motif in the Ace Lake mavirus . AT-rich regions were identified on motif 2 in the Organic Lake virophage, motif 3 in Yellowstone Lake virophage (YSLV)1 and 2, motif 1 in YSLV3, and motif 1 and 2 in YSLV4, respectively. AT-rich regions were distributed widely on the genomes of virophages. All of these motifs may be promoter motifs of virophages. Our results provide insights into further exploration of temporal expression of genes in virophages as well as associations between virophages and giant viruses.
[Mh] Termos MeSH primário: Genômica
Motivos de Nucleotídeos/genética
Regiões Promotoras Genéticas/genética
Vírus Satélites/genética
[Mh] Termos MeSH secundário: Sequência de Bases
Evolução Molecular
Genoma Viral/genética
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1511
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151104
[St] Status:MEDLINE



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