Base de dados : MEDLINE
Pesquisa : B04.280.030.500 [Categoria DeCS]
Referências encontradas : 215 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 22 ir para página                         

  1 / 215 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28410483
[Au] Autor:Molloy CT; Andonian JS; Seltzer HM; Procario MC; Watson ME; Weinberg JB
[Ad] Endereço:Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, USA.
[Ti] Título:Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection.
[So] Source:Virology;507:64-74, 2017 Jul.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CD8 T cells are key components of the immune response to viruses, but their roles in the pathogenesis of adenovirus respiratory infection have not been characterized. We used mouse adenovirus type 1 (MAV-1) to define CD8 T cell contributions to the pathogenesis of adenovirus respiratory infection. CD8 T cell deficiency in ß2m mice had no effect on peak viral replication in lungs, but clearance of virus was delayed in ß2m mice. Virus-induced weight loss and increases in bronchoalveolar lavage fluid total protein, IFN-γ, TNF-α, IL-10, CCL2, and CCL5 concentrations were less in ß2m mice than in controls. CD8 T cell depletion had similar effects on virus clearance, weight loss, and inflammation. Deficiency of IFN-γ or perforin had no effect on viral replication or inflammation, but perforin-deficient mice were partially protected from weight loss. CD8 T cells promote MAV-1-induced pulmonary inflammation via a mechanism that is independent of direct antiviral effects.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Linfócitos T CD8-Positivos/imunologia
Pulmão/imunologia
Mastadenovirus/fisiologia
Doenças dos Roedores/imunologia
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/genética
Infecções por Adenoviridae/imunologia
Infecções por Adenoviridae/virologia
Animais
Feminino
Interferon gama/genética
Interferon gama/imunologia
Interleucina-10/genética
Interleucina-10/imunologia
Pulmão/virologia
Masculino
Mastadenovirus/genética
Mastadenovirus/isolamento & purificação
Camundongos
Camundongos Endogâmicos C57BL
Perforina/genética
Perforina/imunologia
Doenças dos Roedores/genética
Doenças dos Roedores/virologia
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
126465-35-8 (Perforin); 130068-27-8 (Interleukin-10); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


  2 / 215 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28298598
[Au] Autor:Gaba A; Ayalew L; Makadiya N; Tikoo S
[Ad] Endereço:VIDO-InterVac, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
[Ti] Título:Proteolytic Cleavage of Bovine Adenovirus 3-Encoded pVIII.
[So] Source:J Virol;91(10), 2017 May 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Proteolytic maturation involving cleavage of one nonstructural and six structural precursor proteins including pVIII by adenovirus protease is an important aspect of the adenovirus life cycle. The pVIII encoded by bovine adenovirus 3 (BAdV-3) is a protein of 216 amino acids and contains two potential protease cleavage sites. Here, we report that BAdV-3 pVIII is cleaved by adenovirus protease at both potential consensus protease cleavage sites. Usage of at least one cleavage site appears essential for the production of progeny BAdV-3 virions as glycine-to-alanine mutation of both protease cleavage sites appears lethal for the production of progeny virions. However, mutation of a single protease cleavage site of BAdV-3 pVIII significantly affects the efficient production of infectious progeny virions. Further analysis revealed no significant defect in endosome escape, genome replication, capsid formation, and virus assembly. Interestingly, cleavage of pVIII at both potential cleavage sites appears essential for the production of stable BAdV-3 virions as BAdV-3 expressing pVIII containing a glycine-to-alanine mutation of either of the potential cleavage sites is thermolabile, and this mutation leads to the production of noninfectious virions. Here, we demonstrated that the BAdV-3 adenovirus protease cleaves BAdV-3 pVIII at both potential protease cleavage sites. Although cleavage of pVIII at one of the two adenoviral protease cleavage sites is required for the production of progeny virions, the mutation of a single cleavage site of pVIII affects the efficient production of infectious progeny virions. Further analysis indicated that the mutation of a single protease cleavage site (glycine to alanine) of pVIII produces thermolabile virions, which leads to the production of noninfectious virions with disrupted capsids. We thus provide evidence about the requirement of proteolytic cleavage of pVIII for production of infectious progeny virions. We feel that our study has significantly advanced the understanding of the requirement of adenovirus protease cleavage of pVIII.
[Mh] Termos MeSH primário: Proteínas do Capsídeo/metabolismo
Mastadenovirus/enzimologia
Mastadenovirus/metabolismo
Proteólise
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Proteínas do Capsídeo/química
Bovinos
Linhagem Celular
Replicação do DNA
Mastadenovirus/fisiologia
Peptídeo Hidrolases/metabolismo
Proteínas Virais/metabolismo
Montagem de Vírus
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (Viral Proteins); EC 3.4.- (Peptide Hydrolases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171028
[Lr] Data última revisão:
171028
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


  3 / 215 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28053109
[Au] Autor:Ashley SL; Pretto CD; Stier MT; Kadiyala P; Castro-Jorge L; Hsu TH; Doherty R; Carnahan KE; Castro MG; Lowenstein PR; Spindler KR
[Ad] Endereço:Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
[Ti] Título:Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1.
[So] Source:J Virol;91(6), 2017 Mar 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mouse adenovirus type 1 (MAV-1) infection causes encephalitis in susceptible strains of mice and alters the permeability of infected brains to small molecules, which indicates disruption of the blood-brain barrier (BBB). Under pathological conditions, matrix metalloproteinases (MMPs) can disrupt the BBB through their proteolytic activity on basement membrane and tight junction proteins. We examined whether MAV-1 infection alters MMP activity and Infected MAV-1-susceptible SJL mice had higher MMP2 and MMP9 activity in brains, measured by gelatin zymography, than mock-infected mice. Infected MAV-1-resistant BALB/c mice had MMP activity levels equivalent to those in mock infection. Primary SJL mouse brain endothelial cells (a target of MAV-1 ) infected with MAV-1 had no difference in activities of secreted MMP2 and MMP9 from mock cells. We show for the first time that astrocytes and microglia are also infected by MAV-1. Infected mixed primary cultures of astrocytes and microglia had higher levels of MMP2 and MMP9 activity than mock-infected cells. These results indicate that increased MMP activity in the brains of MAV-1-infected susceptible mice may be due to MMP activity produced by endothelial cells, astrocytes, and microglia, which in turn may contribute to BBB disruption and encephalitis in susceptible mice. RNA and DNA viruses can cause encephalitis; in some cases, this is accompanied by MMP-mediated disruption of the BBB. Activated MMPs degrade extracellular matrix and cleave tight-junction proteins and cytokines, modulating their functions. MAV-1 infection of susceptible mice is a tractable small-animal model for encephalitis, and the virus causes disruption of the BBB. We showed that MAV-1 infection increases enzymatic activity of two key MMPs known to be secreted and activated in neuroinflammation, MMP2 and MMP9, in brains of susceptible mice. MAV-1 infects endothelial cells, astrocytes, and microglia, cell types in the neurovascular unit that can secrete MMPs. MAV-1 infection of these cell types caused higher MMP activity than mock infection, suggesting that they may contribute to the higher MMP activity seen To our knowledge, this provides the first evidence of an encephalitic DNA virus in its natural host causing increased MMP activity in brains.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/patologia
Encefalite Viral/patologia
Mastadenovirus/patogenicidade
Metaloproteinase 2 da Matriz/análise
Metaloproteinase 9 da Matriz/análise
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/virologia
Animais
Astrócitos/enzimologia
Astrócitos/virologia
Encéfalo/patologia
Células Cultivadas
Modelos Animais de Doenças
Encefalite Viral/virologia
Células Endoteliais/enzimologia
Células Endoteliais/virologia
Camundongos
Microglia/enzimologia
Microglia/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.24 (Mmp2 protein, mouse); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.35 (Mmp9 protein, mouse)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE


  4 / 215 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27903802
[Au] Autor:Castro-Jorge LA; Pretto CD; Smith AB; Foreman O; Carnahan KE; Spindler KR
[Ad] Endereço:Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
[Ti] Título:A Protective Role for Interleukin-1 Signaling during Mouse Adenovirus Type 1-Induced Encephalitis.
[So] Source:J Virol;91(4), 2017 Feb 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Interleukin-1ß (IL-1ß), an inflammatory cytokine and IL-1 receptor ligand, has diverse activities in the brain. We examined whether IL-1 signaling contributes to the encephalitis observed in mouse adenovirus type 1 (MAV-1) infection, using mice lacking the IL-1 receptor (Il1r1 mice). Il1r1 mice demonstrated reduced survival, greater disruption of the blood-brain barrier (BBB), higher brain viral loads, and higher brain inflammatory cytokine and chemokine levels than control C57BL/6J mice. We also examined infections of mice defective in IL-1ß production (Pycard mice) and mice defective in trafficking of Toll-like receptors to the endosome (Unc93b1 mice). Pycard and Unc93b1 mice showed lower survival (similar to Il1r1 mice) than control mice but, unlike Il1r1 mice, did not have increased brain viral loads or BBB disruption. Based on the brain cytokine levels, MAV-1-infected Unc93b1 mice had a very different inflammatory profile from infected Il1r1 and Pycard mice. Histological examination demonstrated pathological findings consistent with encephalitis in control and knockout mice; however, intranuclear viral inclusions were seen only in Il1r1 mice. A time course of infection of control and Il1r1 mice evaluating the kinetics of viral replication and cytokine production revealed differences between the mouse strains primarily at 7 to 8 days after infection, when mice began succumbing to MAV-1 infection. In the absence of IL-1 signaling, we noted an increase in the transcription of type I interferon (IFN)-stimulated genes. Together, these results indicate that IL-1 signaling is important during MAV-1 infection and suggest that, in its absence, increased IFN-ß signaling may result in increased neuroinflammation. IMPORTANCE: The investigation of encephalitis pathogenesis produced by different viruses is needed to characterize virus and host-specific factors that contribute to disease. MAV-1 produces viral encephalitis in its natural host, providing a good model for studying factors involved in encephalitis development. We investigated the role of IL-1 signaling during MAV-1-induced encephalitis. Unexpectedly, the lack of IL-1 signaling increased the mortality and inflammation in mice infected with MAV-1. Also, there was an increase in the transcription of type I IFN-stimulated genes that correlated with the observed increased mortality and inflammation. The findings highlight the complex nature of encephalitis and suggests that IL-1 has a protective effect for the development of MAV-1-induced encephalitis.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/metabolismo
Infecções por Adenoviridae/virologia
Encefalite/metabolismo
Encefalite/virologia
Interleucina-1/metabolismo
Mastadenovirus/fisiologia
Transdução de Sinais
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/genética
Infecções por Adenoviridae/imunologia
Animais
Barreira Hematoencefálica/metabolismo
Encéfalo/metabolismo
Encéfalo/patologia
Encéfalo/virologia
Citocinas/metabolismo
Endossomos/metabolismo
Interações Hospedeiro-Patógeno
Imunidade Inata
Mediadores da Inflamação/metabolismo
Interleucina-1/genética
Camundongos
Camundongos Knockout
Permeabilidade
Receptores Toll-Like/genética
Receptores Toll-Like/metabolismo
Transcrição Genética
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Inflammation Mediators); 0 (Interleukin-1); 0 (Toll-Like Receptors)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE


  5 / 215 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27807242
[Au] Autor:Hackenbrack N; Rogers MB; Ashley RE; Keel MK; Kubiski SV; Bryan JA; Ghedin E; Holmes EC; Hafenstein SL; Allison AB
[Ad] Endereço:Department of Medicine, The Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
[Ti] Título:Evolution and Cryo-electron Microscopy Capsid Structure of a North American Bat Adenovirus and Its Relationship to Other Mastadenoviruses.
[So] Source:J Virol;91(2), 2017 Jan 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Since the first description of adenoviruses in bats in 2006, a number of micro- and megabat species in Europe, Africa, and Asia have been shown to carry a wide diversity of adenoviruses. Here, we report on the evolutionary, biological, and structural characterization of a novel bat adenovirus (BtAdV) recovered from a Rafinesque's big-eared bat (Corynorhinus rafinesquii) in Kentucky, USA, which is the first adenovirus isolated from North American bats. This virus (BtAdV 250-A) exhibits a close phylogenetic relationship with Canine mastadenovirus A (CAdV A), as previously observed with other BtAdVs. To further investigate the relationships between BtAdVs and CAdVs, we conducted mass spectrometric analysis and single-particle cryo-electron microscopy reconstructions of the BtAdV 250-A capsid and also analyzed the in vitro host ranges of both viruses. Our results demonstrate that BtAdV 250-A represents a new mastadenovirus species that, in contrast to CAdV, has a unique capsid morphology that contains more prominent extensions of protein IX and can replicate efficiently in a phylogenetically diverse range of species. These findings, in addition to the recognition that both the genetic diversity of BtAdVs and the number of different bat species from disparate geographic regions infected with BtAdVs appears to be extensive, tentatively suggest that bats may have served as a potential reservoir for the cross-species transfer of adenoviruses to other hosts, as theorized for CAdV. IMPORTANCE: Although many adenoviruses are host specific and likely codiverged with their hosts over millions of years, other adenoviruses appear to have emerged through successful cross-species transmission events on more recent time scales. The wide geographic distribution and genetic diversity of adenoviruses in bats and their close phylogenetic relationship to Canine mastadenovirus A (CAdV A) has raised important questions about how CAdV A, and possibly other mammalian adenoviruses, may have emerged. Although most adenoviruses tend to cause limited disease in their natural hosts, CAdV A is unusual in that it may cause high morbidity and sometimes fatal infections in immunocompetent hosts and is thus an important pathogen of carnivores. Here, we performed a comparative evolutionary and structural study of representative bat and canine adenoviruses to better understand the relationship between these two viral groups.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/transmissão
Infecções por Adenoviridae/virologia
Evolução Biológica
Capsídeo/metabolismo
Capsídeo/ultraestrutura
Microscopia Crioeletrônica
Mastadenovirus/fisiologia
Mastadenovirus/ultraestrutura
[Mh] Termos MeSH secundário: Animais
Quirópteros
Cães
Ordem dos Genes
Genoma Viral
Especificidade de Hospedeiro
Espectrometria de Massas
Mastadenovirus/classificação
Fases de Leitura Aberta
Filogenia
RNA Viral
Homologia de Sequência
Vírion
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE


  6 / 215 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27521148
[Au] Autor:Zhao X; Tikoo SK
[Ad] Endereço:1​VIDO-InterVac, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada 2​Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.
[Ti] Título:Deletion of pV affects integrity of capsid causing defect in the infectivity of bovine adenovirus-3.
[So] Source:J Gen Virol;97(10):2657-2667, 2016 Oct.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Members of the genus Mastadenovirus including bovine adenovirus 3 (BAdV-3) encode a genus-specific unique protein named pV. The pV encoded by BAdV-3 is a protein of 423 aa showing 40.9 % identity to pV of human adenovirus 2. Here, we report the construction and analysis of recombinant BAdV-3 (BAV.dV) containing deletion of pV. The BAV.dV could only be isolated in CRL.pV cells expressing pV, suggesting that pV appears essential for the infection of BAdV-3. Analysis of BAV.dV suggested that despite affecting some late gene expression in virus-infected cells, there was no significant difference in the incorporation of viral proteins in the mature virions. Moreover, analysis of mature virions revealed degraded capsids leading to change in morphology and infectivity of BAV.dV. Furthermore, analysis of the genome sequence of different clones of BAV.dV passaged in different cell lines revealed no mutations in core proteins pVII and pX\Mu suggesting that the replication defect may not be rescued. Our results suggest that pV is required for proper viral assembly of BAdV-3 as lack of pV produces aberrant capsids. Moreover, altered capsids lead to the production of non-infectious BAV.dV virions.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Capsídeo/metabolismo
Doenças dos Bovinos/virologia
Deleção de Genes
Mastadenovirus/fisiologia
Proteínas Virais/genética
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/virologia
Animais
Bovinos
Linhagem Celular
Mastadenovirus/genética
Mastadenovirus/patogenicidade
Ratos
Proteínas Virais/metabolismo
Virulência
Montagem de Vírus
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160814
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000570


  7 / 215 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27032099
[Au] Autor:Tan B; Yang XL; Ge XY; Peng C; Zhang YZ; Zhang LB; Shi ZL
[Ad] Endereço:1​ Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
[Ti] Título:Novel bat adenoviruses with an extremely large E3 gene.
[So] Source:J Gen Virol;97(7):1625-35, 2016 Jul.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bats carry diverse RNA viruses, some of which are responsible for human diseases. Compared to bat-borne RNA viruses, relatively little information is known regarding bat-borne DNA viruses. In this study, we isolated and characterized three novel bat adenoviruses (BtAdV WIV9-11) from Rhinolophus sinicus. Their genomes, which are highly similar to each other but distinct from those of previously sequenced adenoviruses (AdVs), are 37 545, 37 566 and 38 073 bp in size, respectively. An unusually large E3 gene was identified in their genomes. Phylogenetic and taxonomic analyses suggested that these isolates represent a distinct species of the genus Mastadenovirus. Cell susceptibility assays revealed a broad cell tropism for these isolates, indicating that they have a potentially wide host range. Our results expand the understanding of genetic diversity of bat AdVs.
[Mh] Termos MeSH primário: Proteínas E3 de Adenovirus/genética
Quirópteros/virologia
Genoma Viral/genética
Mastadenovirus/classificação
Mastadenovirus/genética
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Proteínas do Capsídeo/genética
Cercopithecus aethiops
Cricetinae
DNA Viral/genética
Variação Genética/genética
Especificidade de Hospedeiro
Seres Humanos
Macaca mulatta
Filogenia
Análise de Sequência de DNA
Suínos
Tropismo Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adenovirus E3 Proteins); 0 (Capsid Proteins); 0 (DNA, Viral); 0 (hexon capsid protein, Adenovirus)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160401
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000470


  8 / 215 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26370792
[Au] Autor:Pantó L; Podgorski II; Jánoska M; Márkó O; Harrach B
[Ad] Endereço:Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, P. O. Box 18, 1581, Budapest, Hungary.
[Ti] Título:Taxonomy proposal for Old World monkey adenoviruses: characterisation of several non-human, non-ape primate adenovirus lineages.
[So] Source:Arch Virol;160(12):3165-77, 2015 Dec.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:A species classification regarding Old World monkey adenoviruses is proposed. We determined the nucleotide sequences of PCR-amplified fragments from the genes of the IVa2, DNA-dependent DNA polymerase, penton base, and hexon proteins from every simian adenovirus (SAdV) serotype that originated from Old World monkeys for which the full genome sequence had not yet been published. We confirmed that the majority of Old Word monkey SAdVs belong to two previously established species. Interestingly, one is the most recently established human AdV species, Human mastadenovirus G, which includes a single human virus, HAdV-52, as well as SAdV-1, -2, -7, -11, -12, and -15. The other approved species, Simian mastadenovirus A includes SAdV-3, -4, -6, -9, -10, -14, and -48. Several SAdVs (SAdV-5, -8, -49, -50) together with baboon AdV-1 and rhesus monkey AdV strains A1139, A1163, A1173, A1258, A1285, A1296, A1312, A1327 and A1335 have been proposed to be classified into an additional species, Simian mastadenovirus B. Another proposed species, Simian mastadenovirus C has been described for SAdV-19, baboon AdV-2/4 and -3. Our study revealed the existence of four additional AdV lineages. The corresponding new candidate species are Simian mastadenovirus D (for SAdV-13), Simian mastadenovirus E (for SAdV-16), Simian mastadenovirus F (for SAdV-17 and -18), and Simian mastadenovirus G (for SAdV-20). Several biological and genomic properties, such as the host origin, haemagglutination profile, number of fibre genes, and G+C content of the genome, strongly support this classification. Three SAdV strains originating from the American Type Culture Collection turned out to be mixtures of at least two virus types, either of the same species (SAdV-12 and -15 types from Human mastadenovirus G) or of two different species (SAdV-5 types from Simian mastadenovirus B and Human mastadenovirus G).
[Mh] Termos MeSH primário: Adenovirus dos Símios/classificação
Adenovirus dos Símios/isolamento & purificação
Genoma Viral
Doenças dos Macacos/virologia
[Mh] Termos MeSH secundário: Adenovirus dos Símios/genética
Adenovirus dos Símios/fisiologia
Animais
Sequência de Bases
Cercopithecidae/virologia
Especificidade de Hospedeiro
Seres Humanos
Mastadenovirus/classificação
Mastadenovirus/genética
Mastadenovirus/fisiologia
Dados de Sequência Molecular
Fases de Leitura Aberta
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151106
[Lr] Data última revisão:
151106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150916
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-015-2575-z


  9 / 215 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:26270215
[Au] Autor:Bergamaschi B; Rodrigues MT; Silva JV; Kluge M; Luz RB; Fleck JD; Bianchi E; Silva LB; Spilki FR
[Ad] Endereço:Laboratório de Microbiologia Molecular, Universidade Feevale, Novo Hamburgo, RS, BR.
[Ti] Título:Moving beyond classical markers of water quality: detection of enteric viruses and genotoxicity in water of the Sinos River.
[So] Source:Braz J Biol;75(2 Suppl):63-7, 2015 May.
[Is] ISSN:1678-4375
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:It is well recognized that the classical biological and chemical markers of environmental pollution do not necessarily indicate the presence or absence of emerging threats to public health, such as waterborne viruses and genotoxicants. The purpose of this preliminary study was to evaluate the presence of material of enteroviruses (EV), rotavirus (RV) and adenovirus (AdV) and genotoxicity in water samples from points of routine monitoring of water quality in the main course of the Sinos River. The points are classified into different levels of pollution in accordance to the Brazilian federal regulations. Viral genomes from EV, AdV were detected in two of the 4 collection points regardless of the level of urbanisation of the surrounding areas. In contrast, genotoxicity was not observed in piava (Leporinus obtusidens) fingerlings cultivated on these same water samples. Results were compared with classical physical, chemical and microbiological parameters. There was no clear evidence of association between any of the classical markers and the presence of viral genomes in the water samples tested.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Rios/química
Rios/virologia
Qualidade da Água
[Mh] Termos MeSH secundário: Animais
Brasil
Caraciformes/metabolismo
Enterovirus/genética
Enterovirus/isolamento & purificação
Mastadenovirus/genética
Mastadenovirus/isolamento & purificação
Mutagênicos/análise
Rotavirus/genética
Rotavirus/isolamento & purificação
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mutagens); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150814
[Lr] Data última revisão:
150814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150814
[St] Status:MEDLINE


  10 / 215 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26189043
[Au] Autor:Kozak RA; Ackford JG; Slaine P; Li A; Carman S; Campbell D; Welch MK; Kropinski AM; Nagy É
[Ad] Endereço:Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
[Ti] Título:Characterization of a novel adenovirus isolated from a skunk.
[So] Source:Virology;485:16-24, 2015 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adenoviruses are a ubiquitous group of viruses that have been found in a wide range of hosts. A novel adenovirus from a skunk suffering from acute hepatitis was isolated and its DNA genome sequenced. The analysis revealed this virus to be a new member of the genus Mastadenovirus, with a genome of 31,848 bp in length containing 30 genes predicted to encode proteins, and with a G+C content of 49.0%. Global genomic organization indicated SkAdV-1 was similar in organization to bat and canine adenoviruses, and phylogenetic comparison suggested these viruses shared a common ancestor. SkAdV-1 demonstrated an ability to replicate in several mammalian liver cell lines suggesting a potential tropism for this virus.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Genoma Viral
Hepatite Viral Animal/virologia
Mastadenovirus/genética
Mephitidae/virologia
[Mh] Termos MeSH secundário: Doença Aguda
Infecções por Adenoviridae/patologia
Infecções por Adenoviridae/virologia
Sequência de Aminoácidos
Animais
Composição de Bases
Linhagem Celular Tumoral
Quirópteros
Cães
Feminino
Tamanho do Genoma
Hepatite Viral Animal/patologia
Fígado/patologia
Fígado/virologia
Células Madin Darby de Rim Canino
Mastadenovirus/classificação
Mastadenovirus/isolamento & purificação
Dados de Sequência Molecular
Filogenia
Alinhamento de Sequência
Tropismo Viral
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1601
[Cu] Atualização por classe:151023
[Lr] Data última revisão:
151023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150720
[St] Status:MEDLINE



página 1 de 22 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde