Base de dados : MEDLINE
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  1 / 20 MEDLINE  
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[PMID]:28301232
[Au] Autor:Alkie TN; Guenther R; Rautenschlein S
[Ad] Endereço:A Clinic for Poultry, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany.
[Ti] Título:Molecular Characterization of Hemorrhagic Enteritis Viruses (HEV) Detected in HEV-Vaccinated Commercial Turkey Flocks in Germany.
[So] Source:Avian Dis;61(1):96-101, 2017 Mar.
[Is] ISSN:1938-4351
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the application of live hemorrhagic enteritis virus (HEV) vaccines, HEV field outbreaks are suspected to still occur in turkey flocks in Germany. Increasing secondary bacterial infections in HEV-vaccinated flocks suggest that vaccines may be losing efficacy or, possibly, that vaccine strains are causing disease. Thus, the goal of the current study was to investigate the diversity of HEV isolates from fattening turkey flocks between 2008 and 2012 by characterizing the open reading frame (ORF)1 gene at its 5' and 3' ends. Analyses of ORF1 sequences of field isolates and comparison with sequences present in databases revealed that in many cases (13 out of 16 samples), vaccine (avirulent) strains were present. In addition, data indicated the circulation of suspected virulent field isolates and these isolates (3 out of 16) cluster with an early isolate from Germany in the 1980s, but show some mutations in the predicted amino acid (aa) sequences of ORF1 compared to the early isolate. These virulent isolates clearly differ from the spleen-derived avirulent Domermuth vaccine strain used in Germany. In this study, a unique isolate was identified and showed unusual nucleotide mutations that resulted in aa exchanges at the 5' end of ORF1 between aa positions 34 and 174. This genetic drift suggests evolution of HEV including virulent and vaccine-derived strains in the field. This may lead to evasion of vaccinal immunity by drifted viruses and/or an increase in the virulence of field strains.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Doenças das Aves Domésticas/virologia
Siadenovirus/genética
Vacinas Virais/administração & dosagem
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/prevenção & controle
Infecções por Adenoviridae/virologia
Animais
Alemanha
Filogenia
Doenças das Aves Domésticas/imunologia
Doenças das Aves Domésticas/prevenção & controle
Siadenovirus/classificação
Siadenovirus/imunologia
Siadenovirus/isolamento & purificação
Perus/virologia
Vacinação
Proteínas Virais/genética
Proteínas Virais/imunologia
Vacinas Virais/genética
Vacinas Virais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Proteins); 0 (Viral Vaccines)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1637/11506-092916-Reg


  2 / 20 MEDLINE  
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[PMID]:28024457
[Au] Autor:Dhama K; Gowthaman V; Karthik K; Tiwari R; Sachan S; Kumar MA; Palanivelu M; Malik YS; Singh RK; Munir M
[Ad] Endereço:a Avian Diseases Section, Division of Pathology , ICAR-Indian Veterinary Research Institute , Izatnagar , India.
[Ti] Título:Haemorrhagic enteritis of turkeys - current knowledge.
[So] Source:Vet Q;37(1):31-42, 2017 Dec.
[Is] ISSN:1875-5941
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Haemorrhagic enteritis virus (HEV), an adenovirus associated with acute haemorrhagic gastro-intestinal disease of 6-11-week old turkeys predominantly hampers both humoral and cellular immunity. Affected birds are more prone to secondary complications (e.g. colibacillosis and clostridiosis) and failure to mount an effective vaccine-induced immune response. HEV belongs to the new genus Siadenovirus. Feco-oral transmission is the main route of entry of the virus and it mainly colonizes bursa, intestine and spleen. Both naturally occurring virulent and avirulent strains of HEVs are serologically indistinguishable. Recent findings revealed that ORF1, E3 and fib genes are the key factors affecting virulence. The adoption of suitable diagnostic tools, proper vaccination and biosecurity measures have restrained the occurrence of disease epidemics. For diagnostic purposes, the best source of HEV is either intestinal contents or samples from spleen. For rapid detection highly sensitive and specific tests such as quantitative real-time PCR based on Taq man probe has been designed. Avirulent strains of HEV or MSDV can be effectively used as live vaccines. Novel vaccines include recombinant hexon protein-based subunit vaccines or recombinant virus-vectored vaccines using fowl poxvirus (FPV) expressing the native hexon of HEV. Notably, subunit vaccines and recombinant virus vectored vaccines altogether offer high protection against challenge or field viruses. Herein, we converse a comprehensive analysis of the HEV genetics, disease pathobiology, advancements in diagnosis and vaccination along with appropriate prevention and control strategies.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Doenças das Aves Domésticas
Siadenovirus/fisiologia
Perus
Vacinação/veterinária
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/diagnóstico
Infecções por Adenoviridae/prevenção & controle
Infecções por Adenoviridae/virologia
Animais
Enterite/veterinária
Doenças das Aves Domésticas/diagnóstico
Doenças das Aves Domésticas/prevenção & controle
Doenças das Aves Domésticas/virologia
Siadenovirus/genética
Siadenovirus/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Viral Vaccines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1080/01652176.2016.1277281


  3 / 20 MEDLINE  
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[PMID]:27993101
[Au] Autor:Ballmann MZ; Harrach B
[Ad] Endereço:Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences , P.O. Box 18, H-1581 Budapest , Hungary.
[Ti] Título:Detection and partial genetic characterisation of novel avi- and siadenoviruses in racing and fancy pigeons (Columba livia domestica).
[So] Source:Acta Vet Hung;64(4):514-528, 2016 12.
[Is] ISSN:0236-6290
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:Up to now, only a single adenovirus (AdV) isolate seemingly specific for pigeons, hence named pigeon AdV-1 (PiAdV-1), has been characterised at DNA sequence level. In the present work, the prevalence and diversity of AdVs occurring in domestic pigeon were examined by a survey performed on randomly collected samples using a very efficient, consensus nested PCR targeting the viral DNA polymerase gene. The newly detected viruses were characterised by sequencing and phylogeny analysis. Amplification of additional genome fragments was attempted by the use of several other PCR methods aiming at the hexon gene. During a 4-year survey, samples from dead or live, healthy pigeons originating from 27 lofts were examined in Hungary. Almost 50% of the samples (48 out of 97) proved to be positive for AdV. Sequence analysis revealed the presence of four hitherto unknown pigeon AdV types. PiAdV-1 was also identified in one sample. Two novel viruses named PiAdV-2 and -3 were found to belong to the genus Aviadenovirus, and two other novel types (PiAdV-4 and -5) to the genus Siadenovirus. This is the first report on the occurrence of siadenoviruses in birds belonging to the order Columbiformes. Approximately two-thirds of the PiAdV-2 genome was sequenced and analysed.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Aviadenovirus/isolamento & purificação
Doenças das Aves/virologia
Columbidae
Siadenovirus/isolamento & purificação
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/virologia
Animais
Aviadenovirus/genética
Variação Genética
Genoma Viral
Filogenia
Reação em Cadeia da Polimerase
Siadenovirus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE


  4 / 20 MEDLINE  
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[PMID]:26418008
[Au] Autor:Singh AK; Berbís MÁ; Ballmann MZ; Kilcoyne M; Menéndez M; Nguyen TH; Joshi L; Cañada FJ; Jiménez-Barbero J; Benko M; Harrach B; van Raaij MJ
[Ad] Endereço:Departamento de Estructura de Macromoléculas, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
[Ti] Título:Structure and Sialyllactose Binding of the Carboxy-Terminal Head Domain of the Fibre from a Siadenovirus, Turkey Adenovirus 3.
[So] Source:PLoS One;10(9):e0139339, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The virulent form of turkey adenovirus 3 (TAdV-3), also known as turkey hemorrhagic enteritis virus (THEV), is an economically important poultry pathogen, while the avirulent form is used as a vaccine. TAdV-3 belongs to the genus Siadenovirus. The carboxy-terminal region of its fibre does not have significant sequence similarity to any other adenovirus fibre heads of known structure. Two amino acid sequence differences between virulent and avirulent TAdV-3 map on the fibre head: where virulent TAdV-3 contains Ile354 and Thr376, avirulent TAdV-3 contains Met354 and Met376. We determined the crystal structures of the trimeric virulent and avirulent TAdV-3 fibre head domains at 2.2 Å resolution. Each monomer contains a beta-sandwich, which, surprisingly, resembles reovirus fibre head more than other adenovirus fibres, although the ABCJ-GHID topology is conserved in all. A beta-hairpin insertion in the C-strand of each trimer subunit embraces its neighbouring monomer. The avirulent and virulent TAdV-3 fibre heads are identical apart from the exact orientation of the beta-hairpin insertion. In vitro, sialyllactose was identified as a ligand by glycan microarray analysis, nuclear magnetic resonance spectroscopy, and crystallography. Its dissociation constant was measured to be in the mM range by isothermal titration calorimetry. The ligand binds to the side of the fibre head, involving amino acids Glu392, Thr419, Val420, Lys421, Asn422, and Gly423 binding to the sialic acid group. It binds slightly more strongly to the avirulent form. We propose that, in vivo, the TAdV-3 fibre may bind a sialic acid-containing cell surface component.
[Mh] Termos MeSH primário: Lactose/análogos & derivados
Estrutura Terciária de Proteína
Siadenovirus/metabolismo
Ácidos Siálicos/química
Proteínas Virais/química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Sítios de Ligação/genética
Calorimetria/métodos
Configuração de Carboidratos
Sequência de Carboidratos
Cristalografia por Raios X
Lactose/química
Lactose/metabolismo
Espectroscopia de Ressonância Magnética
Modelos Moleculares
Dados de Sequência Molecular
Mutação
Polissacarídeos/química
Polissacarídeos/metabolismo
Ligação Proteica
Siadenovirus/genética
Siadenovirus/patogenicidade
Ácidos Siálicos/metabolismo
Termodinâmica
Proteínas Virais/genética
Proteínas Virais/metabolismo
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polysaccharides); 0 (Sialic Acids); 0 (Viral Proteins); 3J7TAL60G3 (N-acetylneuraminoyllactose); J2B2A4N98G (Lactose)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150930
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0139339


  5 / 20 MEDLINE  
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[PMID]:26159706
[Au] Autor:Kumar P; van den Hurk J; Ayalew LE; Gaba A; Tikoo SK
[Ad] Endereço:Vaccine and Infectious Disease Organization -International Vaccine Center (VIDO- InterVac1), University of Saskatchewan, Saskatoon, S7N 5E3, SK, Canada. panky8@yahoo.com.
[Ti] Título:Proteomic analysis of purified turkey adenovirus 3 virions.
[So] Source:Vet Res;46:79, 2015 Jul 09.
[Is] ISSN:1297-9716
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Turkey adenovirus 3 (TAdV-3) causes high mortality and significant economic losses to the turkey industry. However, little is known about the molecular determinants required for viral replication and pathogenesis. Moreover, TAdV-3 does not grow well in cell culture, thus detailed structural studies of the infectious particle is particularly challenging. To develop a better understanding of virus-host interactions, we performed a comprehensive proteomic analysis of proteinase K treated purified TAdV-3 virions isolated from spleens of infected turkeys, by utilizing one-dimensional liquid chromatography mass spectrometry. Our analysis resulted in the identification of 13 viral proteins associated with TAdV-3 virions including a novel uncharacterized TaV3gp04 protein. Further, we detected 18 host proteins in purified virions, many of which are involved in cell-to cell spread, cytoskeleton dynamics and virus replication. Notably, seven of these host proteins have not yet been reported to be present in any other purified virus. In addition, five of these proteins are known antiviral host restriction factors. The availability of reagents allowed us to identify two cellular proteins (collagen alpha-1 (VI) chain and haemoglobin) in the purified TAdV-3 preparations. These results represent the first comprehensive proteomic profile of TAdV-3 and may provide information for illustrating TAdV-3 replication and pathogenesis.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Doenças das Aves Domésticas/genética
Proteoma/genética
Siadenovirus/genética
Perus
Proteínas Virais/genética
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/genética
Infecções por Adenoviridae/virologia
Animais
Western Blotting/veterinária
Cromatografia Líquida/veterinária
Doenças das Aves Domésticas/virologia
Proteoma/metabolismo
Proteômica
Siadenovirus/metabolismo
Espectrometria de Massas em Tandem/veterinária
Proteínas Virais/metabolismo
Proteínas Estruturais Virais/genética
Proteínas Estruturais Virais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Proteome); 0 (Viral Proteins); 0 (Viral Structural Proteins)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150711
[Lr] Data última revisão:
150711
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150711
[St] Status:MEDLINE
[do] DOI:10.1186/s13567-015-0214-z


  6 / 20 MEDLINE  
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[PMID]:24814929
[Au] Autor:Joseph HM; Ballmann MZ; Garner MM; Hanley CS; Berlinski R; Erdélyi K; Childress AL; Fish SS; Harrach B; Wellehan JF
[Ad] Endereço:College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL 32608, United States.
[Ti] Título:A novel siadenovirus detected in the kidneys and liver of Gouldian finches (Erythura gouldiae).
[So] Source:Vet Microbiol;172(1-2):35-43, 2014 Aug 06.
[Is] ISSN:1873-2542
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A novel siadenovirus was found in six captive Gouldian finches (Erythrura gouldiae) in the United States and Hungary. Histopathological examination revealed inclusions in the kidney of the captive Gouldian finch in the United States, and virions morphologically consistent with adenoviruses were seen by electron microscopy. Partial sequence of the DNA-dependent DNA polymerase gene was gained by consensus PCR and sequencing in all six finches, and all proved to be identical. In one Hungarian finch, additional sequence was obtained from the DNA polymerase gene, the pre-terminal protein (pTP) gene, the 52k gene, and the hexon gene. Bayesian, maximum likelihood, and distance-based analyses showed the novel virus clusters with the siadenoviruses, and is herein referred to as Gouldian finch adenovirus 1. The genes looked at in this study had low G+C percentages, which is common in the genus Siadenovirus, and suggestive of recent host switch. The significance of this virus' presence is unknown at this time as clinical signs of positive birds varied.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Doenças das Aves/virologia
Tentilhões/virologia
Rim/virologia
Fígado/virologia
Siadenovirus/genética
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/epidemiologia
Infecções por Adenoviridae/virologia
Animais
Teorema de Bayes
Doenças das Aves/epidemiologia
DNA Polimerase I/genética
Especificidade de Hospedeiro
Hungria/epidemiologia
Rim/patologia
Fígado/patologia
Filogenia
Siadenovirus/classificação
Siadenovirus/isolamento & purificação
Estados Unidos/epidemiologia
Proteínas Virais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Viral Proteins); EC 2.7.7.- (DNA Polymerase I)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140701
[Lr] Data última revisão:
140701
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140513
[St] Status:MEDLINE


  7 / 20 MEDLINE  
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[PMID]:24811321
[Au] Autor:Lee SY; Kim JH; Park YM; Shin OS; Kim H; Choi HG; Song JW
[Ad] Endereço:Department of Microbiology, College of Medicine, Institute for Viral Diseases, Korea University, Seoul 136-705, Korea. sylee163@gmail.com.
[Ti] Título:A novel adenovirus in Chinstrap penguins (Pygoscelis antarctica) in Antarctica.
[So] Source:Viruses;6(5):2052-61, 2014 May 07.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Adenoviruses (family Adenoviridae) infect various organ systems and cause diseases in a wide range of host species. In this study, we examined multiple tissues from Chinstrap penguins (Pygoscelis antarctica), collected in Antarctica during 2009 and 2010, for the presence of novel adenoviruses by PCR. Analysis of a 855-bp region of the hexon gene of a newly identified adenovirus, designated Chinstrap penguin adenovirus 1 (CSPAdV-1), showed nucleotide (amino acid) sequence identity of 71.8% (65.5%) with South Polar skua 1 (SPSAdV-1), 71% (70%) with raptor adenovirus 1 (RAdV-1), 71.4% (67.6%) with turkey adenovirus 3 (TAdV-3) and 61% (61.6%) with frog adenovirus 1 (FrAdV-1). Based on the genetic and phylogenetic analyses, CSPAdV-1 was classified as a member of the genus, Siadenovirus. Virus isolation attempts from kidney homogenates in the MDTC-RP19 (ATCC® CRL-8135™) cell line were unsuccessful. In conclusion, this study provides the first evidence of new adenovirus species in Antarctic penguins.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Siadenovirus/classificação
Siadenovirus/isolamento & purificação
Spheniscidae/virologia
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/virologia
Estruturas Animais/virologia
Animais
Regiões Antárticas
Análise por Conglomerados
DNA Viral/química
DNA Viral/genética
Dados de Sequência Molecular
Filogenia
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
Homologia de Sequência
Siadenovirus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:150805
[Lr] Data última revisão:
150805
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140510
[St] Status:MEDLINE
[do] DOI:10.3390/v6052052


  8 / 20 MEDLINE  
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[PMID]:24487182
[Au] Autor:Liu X; Li Y; Xu C; Qin J; Hao J; Feng M; Tan L; Jia W; Liao M; Cao W
[Ad] Endereço:Key Laboratory of Veterinary Vaccine Innovation of the Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, The People's Republic of China.
[Ti] Título:Real-time fluorescence loop-mediated isothermal amplification for the diagnosis of hemorrhagic enteritis virus.
[So] Source:Virus Res;183:50-5, 2014 Apr.
[Is] ISSN:1872-7492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Suspected cases of hemorrhagic enteritis associated with hemorrhagic enteritis virus (HEV) are becoming more frequent among yellow chickens in the Guangdong Province of China. In this study, we have developed a one-step, ecumenical, real-time fluorescence loop-mediated isothermal amplification (RealAmp) assay for the rapid diagnosis of HEV. The RealAmp assay was performed at 63°C and reduced the assay time to 15min, using a simple and portable device, the ESE-Quant Tube Scanner. The detection limit of DNA was 1fg/µl, and the detection was specific only to HEV. We also used nested PCR to evaluate the application of the RealAmp assay. The coincidence rate of the two methods was 100%. Our data indicated that the RealAmp assay provides a sensitive, specific, and user-friendly diagnostic tool for the identification and quantification of HEV for field diagnosis and in laboratory research.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Enterite/veterinária
Técnicas de Diagnóstico Molecular/métodos
Técnicas de Amplificação de Ácido Nucleico/métodos
Doenças das Aves Domésticas/diagnóstico
Siadenovirus/isolamento & purificação
Virologia/métodos
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/virologia
Animais
Galinhas
China
Enterite/virologia
Doenças das Aves Domésticas/virologia
Sensibilidade e Especificidade
Temperatura Ambiente
Fatores de Tempo
Medicina Veterinária/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140324
[Lr] Data última revisão:
140324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140204
[St] Status:MEDLINE


  9 / 20 MEDLINE  
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[PMID]:24100566
[Au] Autor:Singh AK; Ballmann MZ; Benko M; Harrach B; van Raaij MJ
[Ad] Endereço:Departamento de Estructura de Macromoléculas, Centro Nacional de Biotecnología (CNB-CSIC), Calle Darwin 3, E-28049 Madrid, Spain.
[Ti] Título:Crystallization of the C-terminal head domain of the fibre protein from a siadenovirus, turkey adenovirus 3.
[So] Source:Acta Crystallogr Sect F Struct Biol Cryst Commun;69(Pt 10):1135-9, 2013 Oct.
[Is] ISSN:1744-3091
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Turkey adenovirus 3 belongs to the genus Siadenovirus. Its predicted fibre protein consists of an N-terminal virus-attachment domain, a central shaft domain and a head domain at the C-terminus. The head domain has little sequence identity to known adenovirus fibre head structures. Crystals of the fibre head domain consisting of amino acids 304-454 with an N-terminal purification tag were produced. Crystals of native and selenomethionine-derivatized protein belonged to space group I23 (unit-cell parameter 99 Å). They diffracted synchrotron radiation to 2.0 and 2.14 Šresolution, respectively, and are expected to contain one monomer in the asymmetric unit.
[Mh] Termos MeSH primário: Siadenovirus/metabolismo
Proteínas Virais/química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Cristalização
Dados de Sequência Molecular
Estrutura Terciária de Proteína
Proteínas Virais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:151001
[Lr] Data última revisão:
151001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131009
[St] Status:MEDLINE
[do] DOI:10.1107/S174430911302397X


  10 / 20 MEDLINE  
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[PMID]:22379053
[Au] Autor:Hall NH; Archer LL; Childress AL; Wellehan JF
[Ad] Endereço:Department of Small Animal Clinical Sciences, University of Florida Veterinary Medical Center, Gainesville, FL, USA. halln@ufl.edu
[Ti] Título:Identification of a novel adenovirus in a cotton-top tamarin (Saguinus oedipus).
[So] Source:J Vet Diagn Invest;24(2):359-63, 2012 Mar.
[Is] ISSN:1943-4936
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel adenovirus was identified in a cotton-top tamarin (Saguinus oedipus) with diarrhea by negative-staining electron microscopy of feces, consensus polymerase chain reaction, and sequencing. Partial sequences were obtained from the DNA-dependent DNA polymerase, the p52k gene, and the hexon. Bayesian and maximum likelihood phylogenetic analyses indicated that the virus is a member of the genus Mastadenovirus, and is herein termed Saguinus siadenovirus 1. The phylogeny of the mastadenoviruses is similar to that of their hosts, supporting coevolution. Support for this was strongest in the analysis of the predicted hexon protein. The obtained sequences were GC-rich, which may suggest a lack of recent host jumps. The diversity and evolution of the adenoviruses of platyrrhine primates merits further investigation. Additional study of the association of this virus with diarrhea is indicated.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Diarreia/veterinária
Doenças dos Macacos/virologia
Saguinus
Siadenovirus/isolamento & purificação
[Mh] Termos MeSH secundário: Infecções por Adenoviridae/virologia
Sequência de Aminoácidos
Animais
Sequência de Bases
Proteínas do Capsídeo/química
Proteínas do Capsídeo/genética
DNA Viral/química
DNA Viral/genética
DNA Polimerase Dirigida por DNA/química
DNA Polimerase Dirigida por DNA/genética
Diarreia/virologia
Fezes/virologia
Feminino
Microscopia Eletrônica de Varredura/veterinária
Dados de Sequência Molecular
Filogenia
Reação em Cadeia da Polimerase/veterinária
Alinhamento de Sequência
Análise de Sequência de DNA
Siadenovirus/genética
Siadenovirus/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (DNA, Viral); 0 (hexon capsid protein, Adenovirus); EC 2.7.7.7 (DNA-Directed DNA Polymerase)
[Em] Mês de entrada:1207
[Cu] Atualização por classe:120301
[Lr] Data última revisão:
120301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120302
[St] Status:MEDLINE
[do] DOI:10.1177/1040638711435809



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