Base de dados : MEDLINE
Pesquisa : B04.280.038.500 [Categoria DeCS]
Referências encontradas : 662 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 67 ir para página                         

  1 / 662 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28591470
[Au] Autor:Ellingson KD; Sapiano MRP; Haass KA; Savinkina AA; Baker ML; Henry RA; Berger JJ; Kuehnert MJ; Basavaraju SV
[Ad] Endereço:Office of Blood, Organ, and Other Tissue Safety, Division of Healthcare Quality Promotion.
[Ti] Título:Cost projections for implementation of safety interventions to prevent transfusion-transmitted Zika virus infection in the United States.
[So] Source:Transfusion;57 Suppl 2:1625-1633, 2017 Jun.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In August 2016, the Food and Drug Administration advised US blood centers to screen all whole blood and apheresis donations for Zika virus (ZIKV) with an individual-donor nucleic acid test (ID-NAT) or to use approved pathogen reduction technology (PRT). The cost of implementing this guidance nationally has not been assessed. STUDY DESIGN AND METHODS: Scenarios were constructed to characterize approaches to ZIKV screening, including universal ID-NAT, risk-based seasonal allowance of minipool (MP) NAT by state, and universal MP-NAT. Data from the 2015 National Blood Collection and Utilization Survey (NBCUS) were used to characterize the number of donations nationally and by state. For each scenario, the estimated cost per donor ($3-$9 for MP-NAT, $7-$13 for ID-NAT) was multiplied by the estimated number of relevant donations from the NBCUS. Cost of PRT was calculated by multiplying the cost per unit ($50-$125) by the number of units approved for PRT. Prediction intervals for costs were generated using Monte Carlo simulation methods. RESULTS: Screening all donations in the 50 states and DC for ZIKV by ID-NAT would cost $137 million (95% confidence interval [CI], $109-$167) annually. Allowing seasonal MP-NAT in states with lower ZIKV risk could reduce NAT screening costs by 18% to 25%. Application of PRT to all platelet (PLT) and plasma units would cost $213 million (95% CI, $156-$304). CONCLUSION: Universal ID-NAT screening for ZIKV will cost US blood centers more than $100 million annually. The high cost of PRT for apheresis PLTs and plasma could be mitigated if, once validated, testing for transfusion transmissible pathogens could be eliminated.
[Mh] Termos MeSH primário: Doadores de Sangue/provisão & distribuição
Transfusão de Sangue/economia
Seleção do Doador/métodos
Infecção pelo Zika virus/prevenção & controle
[Mh] Termos MeSH secundário: Seres Humanos
Técnicas de Diagnóstico Molecular/economia
RNA Viral/sangue
Torque teno virus
Reação Transfusional
Estados Unidos
Infecção pelo Zika virus/economia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1111/trf.14164


  2 / 662 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28542207
[Au] Autor:Lewandowska DW; Schreiber PW; Schuurmans MM; Ruehe B; Zagordi O; Bayard C; Greiner M; Geissberger FD; Capaul R; Zbinden A; Böni J; Benden C; Mueller NJ; Trkola A; Huber M
[Ad] Endereço:Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
[Ti] Título:Metagenomic sequencing complements routine diagnostics in identifying viral pathogens in lung transplant recipients with unknown etiology of respiratory infection.
[So] Source:PLoS One;12(5):e0177340, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lung transplant patients are a vulnerable group of immunosuppressed patients that are prone to frequent respiratory infections. We studied 60 episodes of respiratory symptoms in 71 lung transplant patients. Almost half of these episodes were of unknown infectious etiology despite extensive routine diagnostic testing. METHODS: We re-analyzed respiratory samples of all episodes with undetermined etiology in order to detect potential viral pathogens missed/not accounted for in routine diagnostics. Respiratory samples were enriched for viruses by filtration and nuclease digestion, whole nucleic acids extracted and randomly amplified before high throughput metagenomic virus sequencing. Viruses were identified by a bioinformatic pipeline and confirmed and quantified using specific real-time PCR. RESULTS: In completion of routine diagnostics, we identified and confirmed a viral etiology of infection by our metagenomic approach in four patients (three Rhinovirus A, one Rhinovirus B infection) despite initial negative results in specific multiplex PCR. Notably, the majority of samples were also positive for Torque teno virus (TTV) and Human Herpesvirus 7 (HHV-7). While TTV viral loads increased with immunosuppression in both throat swabs and blood samples, HHV-7 remained at low levels throughout the observation period and was restricted to the respiratory tract. CONCLUSION: This study highlights the potential of metagenomic sequencing for virus diagnostics in cases with previously unknown etiology of infection and in complex diagnostic situations such as in immunocompromised hosts.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/virologia
Transplante de Pulmão
Metagenoma
Complicações Pós-Operatórias/virologia
Infecções por Vírus de RNA/virologia
Infecções Respiratórias/virologia
[Mh] Termos MeSH secundário: Adulto
Infecções por Vírus de DNA/diagnóstico
Feminino
Genoma Viral
Herpesvirus Humano 7/genética
Herpesvirus Humano 7/isolamento & purificação
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Masculino
Metagenômica
Meia-Idade
Infecções por Picornaviridae/virologia
Complicações Pós-Operatórias/diagnóstico
Infecções por Vírus de RNA/diagnóstico
Infecções Respiratórias/diagnóstico
Rhinovirus/genética
Rhinovirus/isolamento & purificação
Infecções por Roseolovirus/diagnóstico
Infecções por Roseolovirus/virologia
Torque teno virus/genética
Torque teno virus/isolamento & purificação
Transplantados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177340


  3 / 662 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27525643
[Au] Autor:Schiemann M; Puchhammer-Stöckl E; Eskandary F; Kohlbeck P; Rasoul-Rockenschaub S; Heilos A; Kozakowski N; Görzer I; Kikic Z; Herkner H; Böhmig GA; Bond G
[Ad] Endereço:1 Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Austria. 2 Department of Virology, Medical University of Vienna, Austria. 3 Division of Transplant Surgery, Department of Surgery, Medical University of Vienna, Austria. 4 Division of Nephrology and Gastroenterology, Department of Pediatrics, Medical University of Vienna, Austria. 5 Department of Clinical Pathology, Medical University of Vienna, Austria. 6 Department of Emergency Medicine, Medical University of Vienna, Austria.
[Ti] Título:Torque Teno Virus Load-Inverse Association With Antibody-Mediated Rejection After Kidney Transplantation.
[So] Source:Transplantation;101(2):360-367, 2017 Feb.
[Is] ISSN:1534-6080
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antibody-mediated rejection (AMR) represents one of the cardinal causes of late allograft loss after kidney transplantation, and there is great need for noninvasive tools improving early diagnosis of this rejection type. One promising strategy might be the quantification of peripheral blood DNA levels of the highly prevalent and apathogenic Torque Teno virus (TTV), which might mirror the overall level of immunosuppression and thus help determine the risk of alloimmune response. METHODS: To assess the association between TTV load in the peripheral blood and AMR, 715 kidney transplant recipients (median, 6.3 years posttransplantation) were subjected to a systematical cross-sectional AMR screening and, in parallel, TTV quantification. RESULTS: Eighty-six of these recipients had donor-specific antibodies and underwent protocol biopsy, AMR-positive patients (n = 46) showed only 25% of the TTV levels measured in patients without AMR (P = 0.003). In a generalized linear model, higher TTV levels were associated with a decreased risk for AMR after adjustment for potential confounders (risk ratio 0.94 per TTV log level; 95% confidence interval 0.90-0.99; P = 0.02). CONCLUSIONS: Future studies will have to clarify whether longitudinal assessment of TTV load might predict AMR risk and help guide the type and intensity of immunosuppression to prevent antibody-mediated graft injury.
[Mh] Termos MeSH primário: Rejeição de Enxerto/imunologia
Isoanticorpos/sangue
Transplante de Rim/efeitos adversos
Torque teno virus/patogenicidade
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Biópsia
Distribuição de Qui-Quadrado
Estudos Transversais
DNA Viral/genética
Feminino
Rejeição de Enxerto/sangue
Rejeição de Enxerto/diagnóstico
Rejeição de Enxerto/virologia
Seres Humanos
Imunidade Humoral
Hospedeiro Imunocomprometido
Imunossupressores/uso terapêutico
Modelos Lineares
Modelos Logísticos
Masculino
Meia-Idade
Razão de Chances
Estudos Prospectivos
Fatores de Risco
Fatores de Tempo
Torque teno virus/genética
Torque teno virus/imunologia
Resultado do Tratamento
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (DNA, Viral); 0 (Immunosuppressive Agents); 0 (Isoantibodies)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160816
[St] Status:MEDLINE
[do] DOI:10.1097/TP.0000000000001455


  4 / 662 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27924796
[Au] Autor:Hettmann A; Demcsák A; Bach Á; Decsi G; Dencs Á; Pálinkó D; Rovó L; Nagy K; Minarovits J; Takács M
[Ad] Endereço:Division of Virology, National Center for Epidemiology, Budapest, Hungary.
[Ti] Título:Detection and Phylogenetic Analysis of Torque Teno Virus in Salivary and Tumor Biopsy Samples from Head and Neck Carcinoma Patients.
[So] Source:Intervirology;59(2):123-129, 2016.
[Is] ISSN:1423-0100
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Because torque teno virus (TTV) has been implicated in tumorigenesis as a cocarcinogen, we studied TTV prevalence in saliva and biopsy samples from head and neck cancer (HNCC) patients, patients with premalignant lesions of oral cancer, and controls. We also wished to determine the TTV genotypes in HNCC patients. METHODS: A seminested polymerase chain reaction (PCR) amplifying the N22 region of the TTV genome, as well as direct sequencing of PCR fragments, was used. RESULTS: TTV prevalence was higher in HNCC patients (saliva: 27/71, 38%; tumor biopsy: 22/74, 30%) than in controls (saliva: 8/56, 14%; oral mucosa: 1/19, 5%). TTV prevalence was also high in patients with premalignant lesions of oral carcinoma (saliva: 9/18, 50%; biopsy: 5/21, 24%). By phylogenetic analysis, TTV belonging mostly to genotypes 1 and 2 was found in HNCC patients. In most of the cases, identical TTV strains were present in the biopsy and salivary sample of the same HNCC patient. In addition, the same TTV strain was detected in 2 laryngeal carcinoma biopsies obtained from 2 independent patients. CONCLUSIONS: Our data are compatible with the idea that TTV might act as a cocarcinogen in certain cases of HNCC. Alternatively, HNCC may facilitate either TTV replication or TTV entry into the saliva.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/epidemiologia
Neoplasias de Cabeça e Pescoço/virologia
Saliva/virologia
Torque teno virus/genética
Torque teno virus/isolamento & purificação
[Mh] Termos MeSH secundário: Adulto
Biópsia
Infecções por Vírus de DNA/diagnóstico
DNA Viral
Feminino
Genoma Viral
Genótipo
Seres Humanos
Neoplasias Laríngeas/virologia
Masculino
Meia-Idade
Neoplasias Bucais/virologia
Filogenia
Reação em Cadeia da Polimerase
Prevalência
Glândulas Salivares/patologia
Glândulas Salivares/virologia
Torque teno virus/classificação
Torque teno virus/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE
[do] DOI:10.1159/000452974


  5 / 662 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27510954
[Au] Autor:Cancela F; Ramos N; Mirazo S; Mainardi V; Gerona S; Arbiza J
[Ad] Endereço:Sección Virología, Facultad de Ciencias, Universidad de la República, Iguá 4225, 11400 Montevideo, Uruguay.
[Ti] Título:Detection and molecular characterization of Torque Teno Virus (TTV) in Uruguay.
[So] Source:Infect Genet Evol;44:501-6, 2016 Oct.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Torque Teno Virus (TTV), member of Anelloviridae family, is considered a worldwide distributed emergent virus and is currently classified into seven genogroups. Interestingly, the pathogenicity of TTV remains unclear. However, it has been constantly associated to hepatitis cases of unknown etiology (HUE) as well as extensively studied in concurrent infections with Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) and Human Immunodeficiency Virus type 1 (HIV-1). In South America, TTV epidemiological data is scant, involving some studies from Brazil, Venezuela, Colombia and Bolivia. The aim of this work was to investigate for the first time in Uruguay the presence of TTV by a nested-PCR system in 85 human serum samples infected with HBV and/or HCV and/or HIV-1 and in HUE cases. Overall, our results reported a TTV infection rate of 79% (67/85). Furthermore, the molecular characterization of Uruguayan strains revealed that one of them clustered in genogroup 1, while the remaining ones formed separate clusters closely related to genogroup 3, which should be confirmed by complete genome sequencing. Further investigation about TTV circulation in Uruguayan population is needed in order to provide additional information about the genetic variability and TTV epidemiology in South America.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/epidemiologia
Infecções por Vírus de DNA/virologia
Torque teno virus/genética
[Mh] Termos MeSH secundário: Genótipo
Seres Humanos
Filogenia
Análise de Sequência de DNA
Torque teno virus/classificação
Uruguai/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160812
[St] Status:MEDLINE


  6 / 662 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Suzuki, Akemi
Texto completo
[PMID]:27329551
[Au] Autor:Barjas-Castro ML; Angerami RN; Cunha MS; Suzuki A; Nogueira JS; Rocco IM; Maeda AY; Vasami FG; Katz G; Boin IF; Stucchi RS; Resende MR; Esposito DL; de Souza RP; da Fonseca BA; Addas-Carvalho M
[Ad] Endereço:Hematology and Transfusion Center, Universidade Estadual de Campinas-UNICAMP, Campinas, SP, Brazil.
[Ti] Título:Probable transfusion-transmitted Zika virus in Brazil.
[So] Source:Transfusion;56(7):1684-8, 2016 Jul.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Zika virus (ZIKV) is an emerging arthropod-borne flavivirus transmitted by Aedes mosquitoes. Recent commentaries regarding ZIKV routes of transmission describe a potential transmission by transfusion. Herein, we report a probable case of transfusion-transmitted ZIKV infection through a platelet transfusion that was detected from postdonation information. CASE REPORT: A blood donor made a voluntary telephone report to the blood donor facility 3 days after donation and informed the facility of a febrile illness (fever, malaise, and headaches). Due to the ongoing dengue epidemic, the initial clinical investigation included dengue among other possible diagnoses. The serology and molecular laboratory results excluded dengue infection. However, stored samples from the donation were positive for ZIKV on reverse transcription-polymerase chain reaction (RT-PCR) analysis. A retrospective investigation demonstrated that the platelet concentrate, which was part of a pool, had been transfused after a liver transplantation. A physician had evaluated the patient 4 days after surgery. Laboratory investigation showed enzyme-linked immunosorbent assay results that were negative for dengue immunoglobulin M antibodies; however, the results were positive for hemagglutination inhibition antibodies against flavivirus. ZIKV RT-PCR and virus isolation analyses in cell cultures from recipient serum were both positive. The sequencing confirmed ZIKV in the donor and patient samples. Ten partial nucleotide sequences from the ZIKV strain that were detected in the donor were aligned and compared with the ZIKV genome detected in the recipient, revealing a 99.8% homology between the two strains. CONCLUSIONS: This is a case of probable transmission of ZIKV through blood transfusion. The patient had been transfused with the blood product from an infected donor, most likely in the incubation period after ZIKV infection but prior to clinical disease onset. This report emphasizes the importance of postdonation information and recipient investigations during outbreaks of potentially blood-borne infections.
[Mh] Termos MeSH primário: Transfusão de Plaquetas/efeitos adversos
Torque teno virus/isolamento & purificação
Infecção pelo Zika virus/transmissão
Zika virus/isolamento & purificação
[Mh] Termos MeSH secundário: Doadores de Sangue
Plaquetas/virologia
Patógenos Transmitidos pelo Sangue
Brasil
Seres Humanos
Masculino
Meia-Idade
Análise de Sequência de RNA
Torque teno virus/genética
Zika virus/genética
Infecção pelo Zika virus/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE
[do] DOI:10.1111/trf.13681


  7 / 662 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27294982
[Au] Autor:Monini M; Vignolo E; Ianiro G; Ostanello F; Ruggeri FM; Di Bartolo I
[Ad] Endereço:Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
[Ti] Título:Detection of Torque Teno Sus Virus in Pork Bile and Liver Sausages.
[So] Source:Food Environ Virol;8(4):283-288, 2016 12.
[Is] ISSN:1867-0342
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Torque teno viruses (TTV) are small DNA viruses widespread among humans and pigs. The clinical significance of TTV infections in either humans or pigs is uncertain. In fact, TTV viremia is highly prevalent in patients with different pathologies, but it can also be frequently observed in healthy subjects. Virus infection in pigs is considered a putative cofactor in several diseases; despite being detected frequently in healthy animals, its role still remains unknown. The present study aimed to investigate the presence of Torque teno sus virus (TTSuV) in 62 bile samples collected from pigs at slaughterhouse and in 36 fresh pork liver sausages bought at point of sale. Quantitative Real-Time PCR, confirmed that 19.4 and 58.3 % of bile and sausage samples tested positive for TTSuV, respectively. The mean viral load was established as 5.6 × 10 GE/µl for bile and 7.16 × 10 GE/g for sausages. TTSuV nucleotide sequence analysis confirmed a wide heterogeneity among the circulating TTSuV strains, which included both TTSuV1 and TTSuV2.
[Mh] Termos MeSH primário: Bile/virologia
Fígado/virologia
Produtos da Carne/virologia
Doenças dos Suínos/virologia
Torque teno virus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Contaminação de Alimentos/análise
Manipulação de Alimentos
Suínos
Torque teno virus/classificação
Torque teno virus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160614
[St] Status:MEDLINE


  8 / 662 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27179346
[Au] Autor:Singh P; Ramamoorthy S
[Ad] Endereço:Department of Veterinary and Microbiological Sciences, North Dakota State University, Dakota State University, Fargo, ND, United States.
[Ti] Título:Lack of strong anti-viral immune gene stimulation in Torque Teno Sus Virus1 infected macrophage cells.
[So] Source:Virology;495:63-70, 2016 Aug.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:While recent findings suggest that swine TTVs (TTSuVs) can act as primary or co-infecting pathogens, very little is known about viral immunity. To determine whether TTSuVs downregulate key host immune responses to facilitate their own survival, a swine macrophage cell line, 3D4/31, was used to over-express recombinant TTSuV1 viral particles or the ORF3 protein. Immune gene expression profiles were assessed by a quantitative PCR panel consisting of 22 immune genes, in cell samples collected at 6, 12, 24 and 48h post-transfection. Despite the upregulation of IFN-ß and TLR9, interferon stimulated innate genes and pro-inflammatory genes were not upregulated in virally infected cells. The adaptive immune genes, IL-4 and IL-13, were significantly downregulated at 6h post-transfection. The ORF3 protein did not appear do not have a major immuno-suppressive effect, nor did it stimulate anti-viral immunity. Data from this study warrants further investigation into the mechanisms of TTV related immuno-pathogenesis.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/genética
Infecções por Vírus de DNA/imunologia
Interações Hospedeiro-Patógeno/genética
Interações Hospedeiro-Patógeno/imunologia
Imunidade Inata/genética
Macrófagos/imunologia
Torque teno virus/imunologia
[Mh] Termos MeSH secundário: Imunidade Adaptativa/genética
Animais
Linhagem Celular
Citocinas/genética
Citocinas/metabolismo
Infecções por Vírus de DNA/metabolismo
Infecções por Vírus de DNA/virologia
Resistência à Doença/genética
Resistência à Doença/imunologia
Genoma Viral
Imunomodulação/genética
Mediadores da Inflamação/metabolismo
Macrófagos/metabolismo
Macrófagos/virologia
Fases de Leitura Aberta
Suínos
Doenças dos Suínos/genética
Doenças dos Suínos/imunologia
Doenças dos Suínos/virologia
Fatores de Tempo
Torque teno virus/patogenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Inflammation Mediators)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160515
[St] Status:MEDLINE


  9 / 662 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27093875
[Au] Autor:Focosi D; Antonelli G; Pistello M; Maggi F
[Ad] Endereço:North-Western Tuscany Blood Bank, Italy.
[Ti] Título:Torquetenovirus: the human virome from bench to bedside.
[So] Source:Clin Microbiol Infect;22(7):589-93, 2016 Jul.
[Is] ISSN:1469-0691
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Torquetenovirus (TTV) is the most abundant component of human virome. Virologists have long ignored this orphan and highly divergent virus, in part because TTV cannot be cultured and because it lacks serology reagents and animal models. Nevertheless, it is almost endemic worldwide and is insensitive to current antiviral drugs, so its monitoring is useful in various conditions. To date, TTV as a marker has proved useful in at least two circumstances: to identify anthropogenic pollution and to assess functional immune competence in immunosuppressed individuals. This review summarizes recent findings about TTV and discusses the main hurdles in translating them into clinical diagnostics.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/virologia
Hospedeiro Imunocomprometido
Microbiota
Torque teno virus/isolamento & purificação
[Mh] Termos MeSH secundário: Interações Hospedeiro-Patógeno
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170126
[Lr] Data última revisão:
170126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160421
[St] Status:MEDLINE


  10 / 662 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
[PMID]:26948255
[Au] Autor:Hosseini SA; Bouzari M
[Ad] Endereço:Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran.
[Ti] Título:Detection of SENV Virus in Healthy, Hepatitis B- and Hepatitis C-Infected Individuals in Yazd Province, Iran.
[So] Source:Iran Biomed J;20(3):168-74, 2016 Jul.
[Is] ISSN:2008-823X
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: SEN virus (SENV) is the latest virus proposed as a cause of unknown hepatitis cases. Among nine detected genotypes of the virus, genotypes D and H are more frequent in hepatitis cases of unknown origin. The aim of this study was to determine the frequency of SENV-D and SENV-H genotypes in the sera of healthy individuals and hepatitis B and C patients. METHODS: Totally, 200 serum samples from healthy individuals as well as 50 hepatitis B and 50 hepatitis C patients were collected. Anti-HCV (hepatitis C virus), anti-human immunodeficiency virus, hepatitis B surface antigen and anti-HBV (hepatitis B virus) core antigen were detected, and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured. Viral DNA was subjected to nested PCR. Fisher's exact and unpaired ANOVA tests were used for statistical analyses. RESULTS: SENV was detected in 90%, 66%, and 46% of the healthy individuals HBV and HCV-positive individuals, respectively. The frequency of SENV and its two genotypes were significantly lower in hepatitis B and hepatitis C patients (P<0.01). Also, the frequency of SENV-H was higher than SENV-D in all studied groups. In SENV-positive HBV patients, the level of ALT and AST enzymes were significantly less than SENV-negative patients (P<0.05). It was the same for SENV-H-negative and -positive cases. CONCLUSIONS: The levels of liver enzymes were significantly lower in HBV patients co-infected with SENV compared to HBV patients (P<0.05), indicating a positive impact of the virus in liver pathology by decreasing liver damage and thus decreasing the liver enzymes.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
DNA Viral/genética
Hepatite B/virologia
Hepatite C/virologia
Torque teno virus/genética
Torque teno virus/isolamento & purificação
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Sequência de Bases
Coinfecção/virologia
Genótipo
Hepacivirus/genética
Hepacivirus/imunologia
Antígenos de Superfície da Hepatite B/imunologia
Vírus da Hepatite B/genética
Vírus da Hepatite B/imunologia
Seres Humanos
Irã (Geográfico)
Fígado/patologia
Fígado/virologia
Análise de Sequência de DNA
Proteínas do Core Viral/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (DNA, Viral); 0 (Hepatitis B Surface Antigens); 0 (Viral Core Proteins); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160308
[St] Status:MEDLINE



página 1 de 67 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde