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[PMID]: 29489682 [Au] Autor: Luo L; Wang H; Fan H; Xie J; Qiu Z; Li T [Ad] Endereço: Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. [Ti] Título: The clinical characteristics and the features of immunophenotype of peripheral lymphocytes of adult onset chronic active Epstein-Barr virus disease at a Tertiary Care Hospital in Beijing. [So] Source: Medicine (Baltimore);97(9):e9854, 2018 Mar. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Chronic active Epstein-Barr virus (CAEBV) infection is a rare disease with high mortality. Most of CAEBV patients have been reported from Japan and are pediatric cases.The goal was to describe the clinical characteristics and the immunophenotypic features of peripheral lymphocytes in adult onset CAEBV patients.We retrospectively reviewed and analyzed all adult onset CAEBV cases admitted to Peking Union Medical College Hospital (PUMCH) between 2012 and 2016. Demographic, clinical, laboratory data, and the immunophentyping data of peripheral lymphocytes were collected.There were 28 adult onset CAEBV patients. The median age was 45 (range, 20-81). Most of the patients presented with fever; splenomegaly; lymphadenopathy and hepatitis. Unlike pediatric cases reported, the manifestations of cardiovascular diseases in our patients were pulmonary arterial hypertension, decreased cardiac function and aorta vasculitis. Prevalence of interstitial pneumonitis in our patients were comparatively higher and prevalence of hypersensitivity to mosquito bites were comparatively lower than that reported by Japan. In this study, CAEBV patients had decreased B cell, NK cell, CD4 cell and CD8 cell counts. The prevalence of low level of B cells, NK cells, CD4 cells was relatively higher than reported ever.Chinese adult onset CAEBV patients have different clinical characteristics and are featured by an immunosuppression status as demonstrated by decreased B cell, NK cell, CD4 cell and CD8 cell. [Mh] Termos MeSH primário: Infecções por Vírus Epstein-Barr/imunologia Herpesvirus Humano 4/imunologia Imunofenotipagem Contagem de Linfócitos [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Linfócitos B/imunologia Linfócitos T CD4-Positivos/imunologia Linfócitos T CD8-Positivos/imunologia China Doença Crônica Infecções por Vírus Epstein-Barr/sangue Feminino Seres Humanos Células Matadoras Naturais/imunologia Masculino Meia-Idade Estudos Retrospectivos Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180307 [Lr] Data última revisão: 180307 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180301 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009854

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[PMID]: 29429163 [Au] Autor: Wu YL; Wu F; Yang L; Sun H; Yan XC; Duan GJ [Ad] Endereço: Department of Pathology, the First Affiliated Hospital, Army Medical University (Third Military Medical University), PLA, Chongqing 400038, China. [Ti] Título: [Clinicopathologic features and prognosis of inflammatory pseudotumor-like follicular dendritic cell sarcomas in liver and spleen: an analysis of seven cases]. [So] Source: Zhonghua Bing Li Xue Za Zhi;47(2):114-118, 2018 Feb 08. [Is] ISSN: 0529-5807 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: To investigate the clinicopathological features and prognostic parameters of the inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) of liver and spleen. Ninteen cases of inflammatory pseudotumor (IPT) and 5 cases of IPT-like FDCS of the liver and spleen were collected at the First Affiliated Hospital, Army Medical University from 2006 to 2016. HE sections, immunohistochemical staining, and Epstein-Barr virus encoded nuclear RNA (EBER) in situ hybridization were reviewed along with a summary of the literature. Among the previously diagnosed 19 cases of IPT of the liver and spleen, 2 cases were misdiagnosed (the ratio of 2/19). Among 7 new cases including 3 males and 4 females, 3 cases involved the liver and 4 cases involved the spleen. The age range was 37-64 years (mean 53 years). The maximum tumor diameter ranged from 3.0 to 11.0 cm (mean 6.5 cm). Surgical resections were performed in all patients with follow-up time ranging from 3 to 84 months.All patients were disease-free.7 new cases were all positive for EBER, and showed the expression of at least one of the FDC markers, including CD21, CD23, and CD35. The rest of 17 cases of IPT were all negative for EBER and essentially negative for FDC markers, but were all positive for SMA. IPT-like FDCS of the liver and spleen is a rare low-grade malignant tumor morphologically mimicking inflammatory pseudotumor, and is easy to be misdiagnosis due to under-recognition. EBER in situ hybridization and FDC markers are indispensable for confirming the diagnosis. [Mh] Termos MeSH primário: Granuloma de Células Plasmáticas/patologia Hepatopatias/patologia Esplenopatias/patologia [Mh] Termos MeSH secundário: Adulto Sarcoma de Células Dendríticas Foliculares/patologia Feminino Herpesvirus Humano 4/genética Seres Humanos Hibridização In Situ Masculino Meia-Idade Prognóstico [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180213 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.0529-5807.2018.02.007

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[PMID]: 28456021 [Au] Autor: Lupey-Green LN; Moquin SA; Martin KA; McDevitt SM; Hulse M; Caruso LB; Pomerantz RT; Miranda JL; Tempera I [Ad] Endereço: Fels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. [Ti] Título: PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter. [So] Source: Virology;507:220-230, 2017 07. [Is] ISSN: 1096-0341 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The Epstein Barr virus (EBV) genome persists in infected host cells as a chromatinized episome and is subject to chromatin-mediated regulation. Binding of the host insulator protein CTCF to the EBV genome has an established role in maintaining viral latency type, and in other herpesviruses, loss of CTCF binding at specific regions correlates with viral reactivation. Here, we demonstrate that binding of PARP1, an important cofactor of CTCF, at the BZLF1 lytic switch promoter restricts EBV reactivation. Knockdown of PARP1 in the Akata-EBV cell line significantly increases viral copy number and lytic protein expression. Interestingly, CTCF knockdown has no effect on viral reactivation, and CTCF binding across the EBV genome is largely unchanged following reactivation. Moreover, EBV reactivation attenuates PARP activity, and Zta expression alone is sufficient to decrease PARP activity. Here we demonstrate a restrictive function of PARP1 in EBV lytic reactivation. [Mh] Termos MeSH primário: Infecções por Vírus Epstein-Barr/enzimologia Infecções por Vírus Epstein-Barr/virologia Herpesvirus Humano 4/fisiologia Poli(ADP-Ribose) Polimerase-1/metabolismo Regiões Promotoras Genéticas Transativadores/genética Ativação Viral [Mh] Termos MeSH secundário: Linhagem Celular Infecções por Vírus Epstein-Barr/genética Regulação Viral da Expressão Gênica Herpesvirus Humano 4/genética Interações Hospedeiro-Patógeno Seres Humanos Poli(ADP-Ribose) Polimerase-1/genética Ligação Proteica Transativadores/metabolismo Latência Viral [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Nm] Nome de substância: 0 (BZLF1 protein, Herpesvirus 4, Human); 0 (Trans-Activators); EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 180304 [Lr] Data última revisão: 180304 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170430 [St] Status: MEDLINE

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[PMID]: 29465599 [Au] Autor: Xie C; Xu X; Wu B; Yang KY; Huang J [Ad] Endereço: Cancer Center. [Ti] Título: Primary pulmonary lymphoepithelioma-like carcinoma in non-endemic region: A case report and literature review. [So] Source: Medicine (Baltimore);97(8):e9976, 2018 Feb. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of lung squamous cell carcinoma. In situ hybridization test for Epstein-Bar virus-encoded RNA (EBER) is generally used for distinguishing it from other lung cancers. Although plasma EBV DNA quantification has been widely used as a tumor biomarker in nasopharyngeal carcinoma (NPC), only a limiting number of studies have suggested that plasma EBV DNA quantification may be used as a tumor marker in pulmonary LELC patients. PATIENT CONCERNS: We report two female patients diagnosed as poorly differentiated squamous cell carcinoma, subsequently, their further histological examinations showed that tumor cells were EBER positive and plasma EBV DNA was detectable. DIAGNOSES: Two patients was diagnosed with advanced pulmonary LELC. INTERVENTIONS: The patients were treated with chemotherapy and chemoradiotherapy respectively. OUTCOMES: Both patients responded well to our treatment, in accordance with their decreased EBV DNA level. LESSONS: Pulmonary LELC is a rare type of lung cancer which is sensitive to chemoradiotherapy, especially in late staged patients. [Mh] Termos MeSH primário: Carcinoma de Células Escamosas/virologia Carcinoma/virologia DNA Viral/sangue Herpesvirus Humano 4/genética Neoplasias Pulmonares/virologia [Mh] Termos MeSH secundário: Adulto Biomarcadores Tumorais/sangue Feminino Seres Humanos Meia-Idade [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Biomarkers, Tumor); 0 (DNA, Viral) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180222 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009976

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[PMID]: 28468596 [Au] Autor: Gloghini A; Volpi CC; Gualeni AV; Dolcetti R; Bongarzone I; De Paoli P; Carbone A [Ad] Endereço: a Molecular Pathology, Department of Diagnostic Pathology and Laboratory Medicine , Fondazione IRCCS Istituto Nazionale dei Tumori , Milano , Italy. [Ti] Título: Multiple viral infections in primary effusion lymphoma: a model of viral cooperation in lymphomagenesis. [So] Source: Expert Rev Hematol;10(6):505-514, 2017 06. [Is] ISSN: 1747-4094 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: INTRODUCTION: Primary effusion lymphoma (PEL) is a rare B-cell lymphoid neoplasm mainly associated with HIV infection, presenting as pleural, peritoneal, and pericardial effusions. A defining property of PEL is its consistent association with Kaposi sarcoma associated herpesvirus (KSHV) infection, and, in most cases, Epstein Barr virus (EBV) co-infection. On these grounds, a review of the literature related to viral cooperation and lymphomagenesis can help to understand the complex interplay between KSHV and EBV in PEL pathogenesis. Areas covered: In this review, the authors highlight clinical, pathologic, genetic and proteomic features of PEL, in the context of viral cooperation in PEL lymphomagenesis. Expert commentary: Tumour cells are characterized by the overexpression of genes that are involved in inflammation and invasion. Coherently, PEL secretomes are enriched in proteins probably responsible for the particular tropism (cell adhesion and migration) of PEL cells. The development of PEL in HIV+ patients is multifactorial and involves a complex interplay among co-infection with oncogenic viruses (EBV and KSHV), inflammatory factors, and environmental conditions. [Mh] Termos MeSH primário: Transformação Celular Viral Infecções por Vírus Epstein-Barr Herpesvirus Humano 4 Herpesvirus Humano 8 Linfoma de Efusão Primária Sarcoma de Kaposi [Mh] Termos MeSH secundário: Infecções por Vírus Epstein-Barr/genética Infecções por Vírus Epstein-Barr/metabolismo Infecções por Vírus Epstein-Barr/patologia Herpesvirus Humano 4/genética Herpesvirus Humano 4/metabolismo Herpesvirus Humano 8/genética Herpesvirus Humano 8/metabolismo Seres Humanos Linfoma de Efusão Primária/metabolismo Linfoma de Efusão Primária/patologia Linfoma de Efusão Primária/virologia Sarcoma de Kaposi/genética Sarcoma de Kaposi/metabolismo Sarcoma de Kaposi/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 180225 [Lr] Data última revisão: 180225 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1080/17474086.2017.1326815

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[PMID]: 29325308 [Au] Autor: Qin L; Qiu ZF; Xie J; Geng TR; Zhao JL; Wan L; Li TS [Ti] Título: [Opportunistic infection in systemic lupus erythematosus patients: the disease spectrum and the characteristics of peripheral lymphocyte subsets]. [So] Source: Zhonghua Nei Ke Za Zhi;57(1):32-36, 2018 Jan 01. [Is] ISSN: 0578-1426 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: To investigate the common opportunistic infections and the characteristics of peripheral lymphocyte subsets in patients with systemic lupus erythematosus (SLE). From December 2013 to December 2016, peripheral lymphocyte subsets were consecutively detected by flow cytometry in treated SLE patients with or without opportunistic infections (OIs) . The lymphocyte subsets in healthy donors were used as normal control group. A total of 145 treated SLE patients were enrolled including 108 with OIs and 37 without OIs. The common OIs were cytomegalovirus (CMV) diseases (66/108), pneumonia (PJP, 16/108), other fungal infections (16/108), Epstein-Barr virus (EBV, 15/108) and tuberculosis (14/108). Compared with treated SLE without OIs, total lymphocyte, CD(4+) T, and CD(8+) T lymphocyte counts were significantly reduced in SLE with OIs [1 260 (780, 1 810) cells/µl vs. 565 (399, 1 043) cells/µl, 0.001; 485 (280, 811) cells/µl vs. 173 (95, 327) cells/µl, 0.001; 464 (339, 764) cells/µl vs. 265 (158, 424) cells/µl, 0.003, respectively]. The common OIs in treated SLE patients were CMV diseases, PJP, other fungi, EBV and tuberculosis. OIs are prone to develop in SLE patients with severe lymphocytopenia, especially CD(4+) T cell depletion. [Mh] Termos MeSH primário: Infecções por Citomegalovirus/diagnóstico Lúpus Eritematoso Sistêmico/diagnóstico Lúpus Eritematoso Sistêmico/imunologia Lúpus Eritematoso Sistêmico/virologia Infecções Oportunistas [Mh] Termos MeSH secundário: Estudos de Casos e Controles Infecções por Citomegalovirus/sangue Infecções por Citomegalovirus/tratamento farmacológico Citometria de Fluxo/métodos Herpesvirus Humano 4/imunologia Herpesvirus Humano 4/patogenicidade Seres Humanos Lúpus Eritematoso Sistêmico/tratamento farmacológico Contagem de Linfócitos Subpopulações de Linfócitos/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180112 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.0578-1426.2018.01.006

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[PMID]: 29270985 [Au] Autor: Liu J; Bian Z; Wang X; Xu LP; Fu Q; Wang C; Chang YJ; Wang Y; Zhang XH; Jiang Z; Huang XJ [Ad] Endereço: Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China. [Ti] Título: Inverse correlation of Vδ2 T-cell recovery with EBV reactivation after haematopoietic stem cell transplantation. [So] Source: Br J Haematol;180(2):276-285, 2018 01. [Is] ISSN: 1365-2141 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Epstein-Barr virus (EBV) reactivation remains a life-threatening complication in recipients of a haploidentical haematopoietic stem cell transplantation (haploHSCT). Reconstitution of adaptive T lymphocytes is generally compromised at the early stages following transplant, suggesting an important role of other effector cells in preventing EBV infection. Our previous studies demonstrated that recovery of CD4 CD8 T cells negatively correlated with EBV reactivation after haploHSCT. In this prospective study on 132 adult patients with haematopoietic malignancy, recovery of T-cell subpopulations was characterized post-haploHSCT. We showed that the median counts of peripheral Vδ2 cells were continuously lower in recipients with EBV reactivation compared with controls at 30, 60 and 90 days after haploHSCT (P values: 0·006, <0·001 and 0·019, respectively). Landmark study further indicated that the cumulative incidence of EBV reactivation was significantly decreased in recipients with higher day-30 Vδ2 counts. Activation of Vδ2 cells upon EBV reactivation was accompanied by an induction of cell apoptosis. Cytotoxic effect of Vδ2 cells on EBV-infected cells was confirmed by in vitro experiments. Together, our findings uncovered a significant correlation of recovered Vδ2 with EBV reactivation following haploHSCT. These results will help to better understand the intrinsic anti-virus immunity and develop γδ T-based therapy strategies after haematopoietic transplantation. [Mh] Termos MeSH primário: Infecções por Vírus Epstein-Barr/etiologia Genes Codificadores da Cadeia delta de Receptores de Linfócitos T Transplante de Células-Tronco Hematopoéticas Herpesvirus Humano 4/fisiologia Linfócitos T/metabolismo Ativação Viral [Mh] Termos MeSH secundário: Adolescente Adulto Apoptose/genética Apoptose/imunologia Citotoxicidade Imunológica Infecções por Vírus Epstein-Barr/diagnóstico Feminino Doença Enxerto-Hospedeiro/etiologia Doença Enxerto-Hospedeiro/prevenção & controle Antígenos HLA/genética Antígenos HLA/imunologia Haplótipos Transplante de Células-Tronco Hematopoéticas/efeitos adversos Seres Humanos Incidência Ativação Linfocitária/imunologia Masculino Meia-Idade Linfócitos T/imunologia Transplante Homólogo Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (HLA Antigens) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171223 [St] Status: MEDLINE [do] DOI: 10.1111/bjh.15037

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[PMID]: 28465297 [Au] Autor: Kaymaz Y; Oduor CI; Yu H; Otieno JA; Ong'echa JM; Moormann AM; Bailey JA [Ad] Endereço: Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts. [Ti] Título: Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences. [So] Source: Mol Cancer Res;15(5):563-576, 2017 05. [Is] ISSN: 1557-3125 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Endemic Burkitt lymphoma (eBL) is the most common pediatric cancer in malaria-endemic equatorial Africa and nearly always contains Epstein-Barr virus (EBV), unlike sporadic Burkitt lymphoma (sBL) that occurs with a lower incidence in developed countries. Given these differences and the variable clinical presentation and outcomes, we sought to further understand pathogenesis by investigating transcriptomes using RNA sequencing (RNAseq) from multiple primary eBL tumors compared with sBL tumors. Within eBL tumors, minimal expression differences were found based on: anatomical presentation site, in-hospital survival rates, and EBV genome type, suggesting that eBL tumors are homogeneous without marked subtypes. The outstanding difference detected using surrogate variable analysis was the significantly decreased expression of key genes in the immunoproteasome complex ( /ß1i, /ß2i, /ß5i, and /PA28ß) in eBL tumors carrying type 2 EBV compared with type 1 EBV. Second, in comparison with previously published pediatric sBL specimens, the majority of the expression and pathway differences was related to the PTEN/PI3K/mTOR signaling pathway and was correlated most strongly with EBV status rather than geographic designation. Third, common mutations were observed significantly less frequently in eBL tumors harboring EBV type 1, with mutation frequencies similar between tumors with EBV type 2 and without EBV. In addition to the previously reported genes, a set of new genes mutated in BL, including , and were identified. Overall, these data establish that EBV, particularly EBV type 1, supports BL oncogenesis, alleviating the need for certain driver mutations in the human genome. IMPLICATIONS: Genomic and mutational analyses of Burkitt lymphoma tumors identify key differences based on viral content and clinical outcomes suggesting new avenues for the development of prognostic molecular biomarkers and therapeutic interventions. [Mh] Termos MeSH primário: Linfoma de Burkitt/genética Infecções por Vírus Epstein-Barr/genética Perfilação da Expressão Gênica/métodos Herpesvirus Humano 4/classificação Mutação [Mh] Termos MeSH secundário: Adolescente Linfoma de Burkitt/virologia Criança Pré-Escolar Doenças Endêmicas Feminino Redes Reguladoras de Genes Genoma Viral Herpesvirus Humano 4/genética Seres Humanos Quênia/epidemiologia Masculino Taxa de Mutação Análise de Sequência de RNA [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180221 [Lr] Data última revisão: 180221 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE [do] DOI: 10.1158/1541-7786.MCR-16-0305

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[PMID]: 27772621 [Au] Autor: Le J [Ad] Endereço: Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: jade.le@utsouthwestern.edu. [Ti] Título: Oncogenic γ Herpesviruses EBV and HHV8 in Kidney Transplantation. [So] Source: Semin Nephrol;36(5):362-371, 2016 09. [Is] ISSN: 1558-4488 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Epstein-Barr virus (EBV) and human herpesvirus-8 (HHV-8) are γ herpesviruses associated with post-transplant malignancies in kidney transplant recipients. EBV is associated with post-transplantation lymphoproliferative disorder (PTLD), with increased risk in EBV-seronegative patients on intensified immunosuppression. Human herpesvirus-8 is associated with Kaposi's sarcoma (KS), with an increased risk in certain patient populations. Diagnosis of PTLD and KS relies on tissue biopsy. The mainstay of therapy for both PTLD and Kaposi's sarcoma is a reduction of immunosuppression, and in the case of PTLD, consideration of rituximab. Chemotherapy, radiation therapy, or surgery is provided for disseminated or recalcitrant disease. The prognoses vary depending on the type of malignancy identified and stage of disease. [Mh] Termos MeSH primário: Infecções por Vírus Epstein-Barr/induzido quimicamente Rejeição de Enxerto/prevenção & controle Imunossupressores/efeitos adversos Falência Renal Crônica/cirurgia Transplante de Rim Transtornos Linfoproliferativos/induzido quimicamente Sarcoma de Kaposi/induzido quimicamente [Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico Antineoplásicos Imunológicos/uso terapêutico Infecções por Vírus Epstein-Barr/diagnóstico Infecções por Vírus Epstein-Barr/tratamento farmacológico Infecções por Herpesviridae/induzido quimicamente Infecções por Herpesviridae/diagnóstico Infecções por Herpesviridae/terapia Infecções por Herpesviridae/virologia Herpesvirus Humano 4 Herpesvirus Humano 8 Seres Humanos Transtornos Linfoproliferativos/diagnóstico Transtornos Linfoproliferativos/terapia Transtornos Linfoproliferativos/virologia Radioterapia Rituximab/uso terapêutico Sarcoma de Kaposi/diagnóstico Sarcoma de Kaposi/terapia Sarcoma de Kaposi/virologia Procedimentos Cirúrgicos Operatórios [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Antineoplastic Agents, Immunological); 0 (Immunosuppressive Agents); 4F4X42SYQ6 (Rituximab) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 29247573 [Au] Autor: Yoshizaki T; Kondo S; Endo K; Nakanishi Y; Aga M; Kobayashi E; Hirai N; Sugimoto H; Hatano M; Ueno T; Ishikawa K; Wakisaka N [Ad] Endereço: Department of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan. [Ti] Título: Modulation of the tumor microenvironment by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. [So] Source: Cancer Sci;109(2):272-278, 2018 Feb. [Is] ISSN: 1349-7006 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Latent membrane protein 1 (LMP1) is a primary oncogene encoded by the Epstein-Barr virus, and various portions of LMP1 are detected in nasopharyngeal carcinoma (NPC) tumor cells. LMP1 has been extensively studied since the discovery of its transforming property in 1985. LMP1 promotes cancer cell growth during NPC development and facilitates the interaction of cancer cells with surrounding stromal cells for invasion, angiogenesis, and immune modulation. LMP1 is detected in 100% of pre-invasive NPC tumors and in approximately 50% of advanced NPC tumors. Moreover, a small population of LMP1-expressing cells in advanced NPC tumor tissue is proposed to orchestrate NPC tumor tissue maintenance and development through cancer stem cells and progenitor cells. Recent studies suggest that LMP1 activity shifts according to tumor development stage, but it still has a pivotal role during all stages of NPC development. [Mh] Termos MeSH primário: Carcinoma/patologia Infecções por Vírus Epstein-Barr/metabolismo Neoplasias Nasofaríngeas/patologia Proteínas da Matriz Viral/metabolismo [Mh] Termos MeSH secundário: Carcinoma/metabolismo Carcinoma/virologia Proliferação Celular Herpesvirus Humano 4/metabolismo Seres Humanos Neoplasias Nasofaríngeas/metabolismo Neoplasias Nasofaríngeas/virologia Estadiamento de Neoplasias Células-Tronco Neoplásicas/metabolismo Microambiente Tumoral [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (EBV-associated membrane antigen, Epstein-Barr virus); 0 (Viral Matrix Proteins) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171217 [St] Status: MEDLINE [do] DOI: 10.1111/cas.13473

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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