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Pesquisa : B04.280.375.650 [Categoria DeCS]
Referências encontradas : 27 [refinar]
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  1 / 27 MEDLINE  
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[PMID]:25833941
[Au] Autor:Mason WS
[Ad] Endereço:Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
[Ti] Título:Animal models and the molecular biology of hepadnavirus infection.
[So] Source:Cold Spring Harb Perspect Med;5(4), 2015 Apr 01.
[Is] ISSN:2157-1422
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Australian antigen, the envelope protein of hepatitis B virus (HBV), was discovered in 1967 as a prevalent serum antigen in hepatitis B patients. Early electron microscopy (EM) studies showed that this antigen was present in 22-nm particles in patient sera, which were believed to be incomplete virus. Complete virus, much less abundant than the 22-nm particles, was finally visualized in 1970. HBV was soon found to infect chimpanzees, gorillas, orangutans, gibbon apes, and, more recently, tree shrews (Tupaia belangeri) and cynomolgus macaques (Macaca fascicularis). This restricted host range placed limits on the kinds of studies that might be performed to better understand the biology and molecular biology of HBV and to develop antiviral therapies to treat chronic infections. About 10 years after the discovery of HBV, this problem was bypassed with the discovery of viruses related to HBV in woodchucks, ground squirrels, and ducks. Although unlikely animal models, their use revealed the key steps in hepadnavirus replication and in the host response to infection, including the fact that the viral nuclear episome is the ultimate target for immune clearance of transient infections and antiviral therapy of chronic infections. Studies with these and other animal models have also suggested interesting clues into the link between chronic HBV infection and hepatocellular carcinoma.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Infecções por Hepadnaviridae/virologia
Hepadnaviridae/genética
[Mh] Termos MeSH secundário: Animais
DNA Viral/biossíntese
Genoma Viral
Hepadnaviridae/classificação
Hepadnaviridae/fisiologia
Vírus da Hepatite B do Pato
Hepatite B Crônica/virologia
Seres Humanos
Neoplasias Hepáticas/virologia
Orthohepadnavirus
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150403
[St] Status:MEDLINE


  2 / 27 MEDLINE  
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[PMID]:25193071
[Au] Autor:He B; Zhang F; Xia L; Hu T; Chen G; Qiu W; Fan Q; Feng Y; Guo H; Tu C
[Ad] Endereço:Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, 666 Liuying West Road, Jingyue Economic Development Zone, Changchun, 130122, People's Republic of China.
[Ti] Título:Identification of a novel Orthohepadnavirus in pomona roundleaf bats in China.
[So] Source:Arch Virol;160(1):335-7, 2015 Jan.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Bats in Myanmar, Gabon, and Panama have been found to harbor diverse hepadnaviruses. Here, we report a novel hepadnavirus in 4 of 20 pomona roundleaf bats from Yunnan province, China. This virus contains 3,278 nucleotides (nt) in the full circularized genome, with four predicted open frames (ORFs) reading in the same direction. Full genomic sequence comparisons and evolutionary analysis indicate that this virus is a member of a new species within the genus Orthohepadnavirus.
[Mh] Termos MeSH primário: Quirópteros
Infecções por Hepadnaviridae/veterinária
Hepatite Viral Animal/virologia
Orthohepadnavirus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
China/epidemiologia
Variação Genética
Infecções por Hepadnaviridae/epidemiologia
Infecções por Hepadnaviridae/virologia
Hepatite Viral Animal/epidemiologia
Orthohepadnavirus/genética
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1503
[Cu] Atualização por classe:150106
[Lr] Data última revisão:
150106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140907
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-014-2222-0


  3 / 27 MEDLINE  
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[PMID]:25320725
[Au] Autor:Wong GL
[Ad] Endereço:Institute of Digestive Disease, Department of Medicine and Therapeutics, and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
[Ti] Título:Prediction of fibrosis progression in chronic viral hepatitis.
[So] Source:Clin Mol Hepatol;20(3):228-36, 2014 Sep.
[Is] ISSN:2287-285X
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Prediction of liver fibrosis progression has a key role in the management of chronic viral hepatitis, as it will be translated into the future risk of cirrhosis and its various complications including hepatocellular carcinoma. Both hepatitis B and C viruses mainly lead to fibrogenesis induced by chronic inflammation and a continuous wound healing response. At the same time direct and indirect profibrogenic responses are also elicited by the viral infection. There are a handful of well-established risk factors for fibrosis progression including older age, male gender, alcohol use, high viral load and co-infection with other viruses. Metabolic syndrome is an evolving risk factor of fibrosis progression. The new notion of regression of advanced fibrosis or even cirrhosis is now strongly supported various clinical studies. Even liver biopsy retains its important role in the assessment of fibrosis progression, various non-invasive assessments have been adopted widely because of their non-invasiveness, which facilitates serial applications in large cohorts of subjects. Transient elastography is one of the most validated tools which has both diagnostic and prognostic role. As there is no single perfect test for liver fibrosis assessment, algorithms combining the most validated noninvasive methods should be considered as initial screening tools.
[Mh] Termos MeSH primário: Hepatite Crônica/patologia
Hepatite Viral Humana/patologia
Cirrose Hepática/patologia
[Mh] Termos MeSH secundário: Fatores Etários
Antivirais/uso terapêutico
Biomarcadores/sangue
Hepatite Crônica/tratamento farmacológico
Hepatite Viral Humana/tratamento farmacológico
Seres Humanos
Fígado/diagnóstico por imagem
Orthohepadnavirus/genética
Fatores de Risco
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Biomarkers)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141017
[St] Status:MEDLINE
[do] DOI:10.3350/cmh.2014.20.3.228


  4 / 27 MEDLINE  
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[PMID]:23631923
[Au] Autor:He B; Fan Q; Yang F; Hu T; Qiu W; Feng Y; Li Z; Li Y; Zhang F; Guo H; Zou X; Tu C
[Ad] Endereço:Academy of Military Medical Sciences, Changchun, People's Republic of China.
[Ti] Título:Hepatitis virus in long-fingered bats, Myanmar.
[So] Source:Emerg Infect Dis;19(4):638-40, 2013 Apr.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During an analysis of the virome of bats from Myanmar, a large number of reads were annotated to orthohepadnaviruses. We present the full genome sequence and a morphological analysis of an orthohepadnavirus circulating in bats. This virus is substantially different from currently known members of the genus Orthohepadnavirus and represents a new species.
[Mh] Termos MeSH primário: Quirópteros/virologia
Genoma Viral
Hepatite Viral Animal/epidemiologia
Orthohepadnavirus/genética
RNA Viral/genética
[Mh] Termos MeSH secundário: Animais
Hepatite Viral Animal/virologia
Mianmar/epidemiologia
Orthohepadnavirus/classificação
Orthohepadnavirus/isolamento & purificação
Filogenia
Reação em Cadeia da Polimerase
Prevalência
RNA Viral/classificação
RNA Viral/isolamento & purificação
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:150427
[Lr] Data última revisão:
150427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130502
[St] Status:MEDLINE
[do] DOI:10.3201/eid1904.121655


  5 / 27 MEDLINE  
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[PMID]:21850270
[Au] Autor:van Hemert FJ; van de Klundert MA; Lukashov VV; Kootstra NA; Berkhout B; Zaaijer HL
[Ad] Endereço:Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. f.j.vanhemert@amc.uva.nl
[Ti] Título:Protein X of hepatitis B virus: origin and structure similarity with the central domain of DNA glycosylase.
[So] Source:PLoS One;6(8):e23392, 2011.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Orthohepadnavirus (mammalian hosts) and avihepadnavirus (avian hosts) constitute the family of Hepadnaviridae and differ by their capability and inability for expression of protein X, respectively. Origin and functions of X are unclear. The evolutionary analysis at issue of X indicates that present strains of orthohepadnavirus started to diverge about 25,000 years ago, simultaneously with the onset of avihepadnavirus diversification. These evolutionary events were preceded by a much longer period during which orthohepadnavirus developed a functional protein X while avihepadnavirus evolved without X. An in silico generated 3D-model of orthohepadnaviral X protein displayed considerable similarity to the tertiary structure of DNA glycosylases (key enzymes of base excision DNA repair pathways). Similarity is confined to the central domain of MUG proteins with the typical DNA-binding facilities but without the capability of DNA glycosylase enzymatic activity. The hypothetical translation product of a vestigial X reading frame in the genome of duck hepadnavirus could also been folded into a DNA glycosylase-like 3D-structure. In conclusion, the most recent common ancestor of ortho- and avihepadnavirus carried an X sequence with orthology to the central domain of DNA glycosylase.
[Mh] Termos MeSH primário: DNA Glicosilases/química
DNA Glicosilases/metabolismo
Transativadores/química
Transativadores/metabolismo
[Mh] Termos MeSH secundário: Animais
Avihepadnavirus/enzimologia
DNA Glicosilases/genética
Seres Humanos
Orthohepadnavirus/enzimologia
Estrutura Secundária de Proteína
Transativadores/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Trans-Activators); 0 (hepatitis B virus X protein); EC 3.2.2.- (DNA Glycosylases)
[Em] Mês de entrada:1202
[Cu] Atualização por classe:150204
[Lr] Data última revisão:
150204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110819
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0023392


  6 / 27 MEDLINE  
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[PMID]:21692673
[Au] Autor:Razonable RR
[Ad] Endereço:Division of Infectious Diseases, Department of Medicine, and the William J von Leibig Transplant Center, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. razonable.raymund@mayo.edu
[Ti] Título:Management of viral infections in solid organ transplant recipients.
[So] Source:Expert Rev Anti Infect Ther;9(6):685-700, 2011 Jun.
[Is] ISSN:1744-8336
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Management of viral infections after transplantation involves antiviral drug therapy (if available) and reduction in immunosuppression, which allows for development of pathogen-specific immunity to the offending virus. Prevention of viral infections is of the utmost importance, and this may be accomplished through vaccination, antiviral strategies and infection control measures. This article discusses the current management of selected viral pathogens that cause clinical illness in solid organ transplant recipients. The benefits and toxicities of antiviral therapies are discussed in the context of prevention and treatment of various viral diseases. The emerging issue of antiviral resistance is emphasized for cytomegalovirus, recurrent hepatitis B and influenza, while the importance of immunominimization is discussed in the management of BK nephropathy and virus-associated malignancies.
[Mh] Termos MeSH primário: Antivirais/uso terapêutico
Infecções por Citomegalovirus/terapia
Hepatite Viral Humana/terapia
Infecções por Herpesviridae/terapia
Imunossupressão/efeitos adversos
Influenza Humana/terapia
Transplante de Órgãos/efeitos adversos
Infecções por Polyomavirus/terapia
Transplantes
[Mh] Termos MeSH secundário: Vírus BK/crescimento & desenvolvimento
Ensaios Clínicos como Assunto
Citomegalovirus/crescimento & desenvolvimento
Infecções por Citomegalovirus/imunologia
Infecções por Citomegalovirus/virologia
Hepatite Viral Humana/imunologia
Hepatite Viral Humana/virologia
Herpesviridae/crescimento & desenvolvimento
Infecções por Herpesviridae/imunologia
Infecções por Herpesviridae/virologia
Seres Humanos
Imunização/métodos
Hospedeiro Imunocomprometido
Influenza Humana/imunologia
Influenza Humana/virologia
Orthohepadnavirus/crescimento & desenvolvimento
Orthomyxoviridae/crescimento & desenvolvimento
Infecções por Polyomavirus/imunologia
Infecções por Polyomavirus/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents)
[Em] Mês de entrada:1112
[Cu] Atualização por classe:110622
[Lr] Data última revisão:
110622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110623
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1586/eri.11.43


  7 / 27 MEDLINE  
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[PMID]:21045353
[Au] Autor:Mustufa MA; Memon AA; Nasim S; Shahid A; Omar SM
[Ad] Endereço:PMRC Specialized Research Center, National Institute of Child Health (NICH), Karachi, Pakistan. a_m_bukero@yahoo.com
[Ti] Título:Exposure to risk factors for hepatitis B and C viruses among primary school teachers in Karachi.
[So] Source:J Infect Dev Ctries;4(10):616-20, 2010 Oct 28.
[Is] ISSN:1972-2680
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The study aimed to determine hepatitis B vaccination status and assess the exposure of risk factors for hepatitis B and C among primary schoolteachers in Karachi, Pakistan. METHODOLOGY: In two hundred school teachers from 30 primary schools in Karachi participated in the study between January and June 2008 by completing an anonymous, self-administered questionnaire. Exposure to and knowledge of hepatitis B and C were assessed, as well as mode of transmission and prevention. The percentage of vaccinated and non-vaccinated teachers was also estimated. RESULTS: Only 73 (36.5%) respondents were vaccinated against HBV. Nine percent (17) of the teachers had received more than 10 therapeutic injections while about 56% (101) took between 5-10 injections per annum. Fifteen (8%) of the teachers confirmed they had been injected with re-used syringes. More than 8% (17) of participants' family members were suffering from hepatitis B or C, while 10% (20) of family members had died of liver diseases without any known history. More than 13% (27) of participants shared razors, brushes, cigarettes and hukahs. Statistically significant difference was also observed in risk factors of hepatitis B and C among male and female respondents. CONCLUSION: Hepatitis B vaccination among school teachers of Karachi was around 37% with a high use of therapeutic injections and syringe reuse. Health awareness programs and educational workshops are needed for teachers, who can later educate the children.
[Mh] Termos MeSH primário: Docentes
Hepatite B/epidemiologia
Hepatite C/epidemiologia
Instituições Acadêmicas
[Mh] Termos MeSH secundário: Adulto
Feminino
Conhecimentos, Atitudes e Prática em Saúde
Hepatite B/prevenção & controle
Hepatite B/transmissão
Vacinas contra Hepatite B/administração & dosagem
Hepatite C/prevenção & controle
Hepatite C/transmissão
Seres Humanos
Masculino
Meia-Idade
Orthohepadnavirus
Paquistão/epidemiologia
Fatores de Risco
Inquéritos e Questionários
Vacinação/utilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hepatitis B Vaccines)
[Em] Mês de entrada:1105
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101104
[St] Status:MEDLINE


  8 / 27 MEDLINE  
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[PMID]:20551540
[Au] Autor:Arora D; Arora B; Khetarpal A
[Ad] Endereço:Department of Pathology, Maharaja Agrasen Medical College, Agroha-125047 (Hisar) Haryana, India.
[Ti] Título:Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana.
[So] Source:Indian J Pathol Microbiol;53(2):308-9, 2010 Apr-Jun.
[Is] ISSN:0974-5130
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Blood transfusion is an important mode of transmission of infections to recipients. The aim of the study was to assess the prevalence of transfusion-transmissible infections among blood donors. For this, a 3.5-year retrospective study, from October 2002 to April 2006 was conducted at the blood transfusion centre of Maharaja Agrasen Medical College, Agroha (Hisar) Haryana. Donors were screened for seroprevalence of HIV, HBV, HCV and syphilis. A total of 5849 donors were tested, out of which 4010 (68.6%) were replacement donors and 1839 (31.4%) were voluntary donors. The seroprevalence of HIV was 0.3% in the donors. No voluntary donor was found to be positive for HIV. The low sero-positivity among donors is attributed to pre-donation counseling in donor selection. The seroprevalence of HBV, HCV and syphilis was 1.7%, 1.0% and 0.9% respectively in total donors. The seroprevalence of hepatitis and syphilis was more in replacement donors as compared to voluntary donors.
[Mh] Termos MeSH primário: Doadores de Sangue
Infecções por HIV/epidemiologia
Hepatite B/epidemiologia
Hepatite C/epidemiologia
Sífilis/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Feminino
Soroprevalência de HIV
Hepacivirus
Seres Humanos
Índia/epidemiologia
Masculino
Orthohepadnavirus
Estudos Soroepidemiológicos
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1009
[Cu] Atualização por classe:100616
[Lr] Data última revisão:
100616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100617
[St] Status:MEDLINE
[do] DOI:10.4103/0377-4929.64295


  9 / 27 MEDLINE  
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[PMID]:20233455
[Au] Autor:Li W; She R; Liu L; You H; Yin J
[Ad] Endereço:College of Veterinary Medicine, China Agricultural University, Beijing, China.
[Ti] Título:Prevalence of a virus similar to human hepatitis B virus in swine.
[So] Source:Virol J;7:60, 2010 Mar 17.
[Is] ISSN:1743-422X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The objective of this study is to established evidence of the existence of a novel member of the hepadnavirus family endemic in swine. Temporarily this virus was designated as swine hepatitis B virus (SHBV). This SHBV can be detected by using human hepatitis B virus diagnostic kits including ELISA, immunohistochemical staining, and transmission electron microscopy (TEM). Also seroprevalence of pig farms in Beijing, China, and pathological features of SHBV infection was determined. RESULTS: Screened result shows that overall prevalence of HBsAg was 24.8%, closed to that of anti-HBsAg, whereas HBeAg and anti-HBe were barely detectable. The distribution of HBsAg and HBcAg was examined by immunohistochemistry of liver samples. Typical hepatitis pathological change, such as spotty parenchymal cell degeneration, necrosis of hepatocytes and proliferation of fibrous connective tissue were observed during histopathological analysis. Analysis of HBsAg-positive serum with TEM revealed two morphologic forms, 20 nm and 40 nm sized particles, similar to small spherical and Danes particles of HBV. Observation of the ultrastructure of the liver also found HBV-like particles in the nucleus of hepatocytes. CONCLUSION: Our research result implies that SHBV could be a causative agent of swine. The discovery of SHBV will unveil novel evolutionary aspects of hepatitis and provides new information for further hepadnavirus research.
[Mh] Termos MeSH primário: Infecções por Hepadnaviridae/epidemiologia
Hepatite Viral Animal/epidemiologia
Orthohepadnavirus/classificação
Orthohepadnavirus/imunologia
Doenças dos Suínos/epidemiologia
[Mh] Termos MeSH secundário: Animais
China/epidemiologia
Doenças Endêmicas
Ensaio de Imunoadsorção Enzimática
Infecções por Hepadnaviridae/virologia
Anticorpos Anti-Hepatite B/sangue
Antígenos de Superfície da Hepatite B/sangue
Antígenos E da Hepatite B/sangue
Hepatite Viral Animal/virologia
Histocitoquímica
Seres Humanos
Imuno-Histoquímica
Fígado/patologia
Fígado/virologia
Microscopia
Microscopia Eletrônica de Transmissão
Orthohepadnavirus/isolamento & purificação
Estudos Soroepidemiológicos
Suínos
Doenças dos Suínos/virologia
Vírion/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hepatitis B Antibodies); 0 (Hepatitis B Surface Antigens); 0 (Hepatitis B e Antigens)
[Em] Mês de entrada:1004
[Cu] Atualização por classe:141204
[Lr] Data última revisão:
141204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100318
[St] Status:MEDLINE
[do] DOI:10.1186/1743-422X-7-60


  10 / 27 MEDLINE  
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[PMID]:19950245
[Au] Autor:Revill P; Yuen L; Walsh R; Perrault M; Locarnini S; Kramvis A
[Ad] Endereço:Victorian Infectious Diseases Reference Laboratory, North Melbourne, Australia. Peter.Revill@mh.org.au
[Ti] Título:Bioinformatic analysis of the hepadnavirus e-antigen and its precursor identifies remarkable sequence conservation in all orthohepadnaviruses.
[So] Source:J Med Virol;82(1):104-15, 2010 Jan.
[Is] ISSN:1096-9071
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The hepatitis B e-antigen (HBeAg) is a non-particulate secretory protein expressed by all viruses within the family Hepadnaviridae. It is not essential for viral assembly or replication but is important for establishment of persistent infection in vivo. Although the exact mechanism(s) by which the HBeAg manifests chronicity are unclear, the HBeAg elicits both humoral and cell-mediated immunity, down-regulates the innate immune response to infection, as well as functioning as a T cell tolerogen and regulating the immune response to the intracellular nucleocapsid. A bioinformatics approach was used to show that the HBeAg and precursory genetic codes share remarkable sequence conservation in all mammalian-infecting hepadnaviruses, irrespective of host, genotype, or geographic origin. Whilst much of this sequence conservation was within key immunomodulatory epitopes, highest conservation was observed at the unique HBeAg N-terminus, suggesting this sequence in particular may play an important role in HBeAg function.
[Mh] Termos MeSH primário: Sequência de Aminoácidos
Sequência Conservada
Hepadnaviridae/imunologia
Antígenos E da Hepatite B/genética
Orthohepadnavirus
Precursores de Proteínas
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Biologia Computacional
Genótipo
Hepadnaviridae/genética
Antígenos E da Hepatite B/química
Antígenos E da Hepatite B/metabolismo
Dados de Sequência Molecular
Mutação
Orthohepadnavirus/genética
Orthohepadnavirus/imunologia
Precursores de Proteínas/química
Precursores de Proteínas/genética
Precursores de Proteínas/metabolismo
Alinhamento de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hepatitis B e Antigens); 0 (Protein Precursors)
[Em] Mês de entrada:1002
[Cu] Atualização por classe:091216
[Lr] Data última revisão:
091216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091202
[St] Status:MEDLINE
[do] DOI:10.1002/jmv.21645



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde