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  1 / 6938 MEDLINE  
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[PMID]:29458559
[Au] Autor:Wada Y; Sasaki M; Setiyono A; Handharyani E; Rahmadani I; Taha S; Adiani S; Latief M; Kholilullah ZA; Subangkit M; Kobayashi S; Nakamura I; Kimura T; Orba Y; Sawa H
[Ad] Endereço:1​Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.
[Ti] Título:Detection of novel gammaherpesviruses from fruit bats in Indonesia.
[So] Source:J Med Microbiol;67(3):415-422, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bats are an important natural reservoir of zoonotic viral pathogens. We previously isolated an alphaherpesvirus in fruit bats in Indonesia, and here establish the presence of viruses belonging to other taxa of the family Herpesviridae. We screened the same fruit bat population with pan-herpesvirus PCR and discovered 68 sequences of novel gammaherpesvirus, designated 'megabat gammaherpesvirus' (MgGHV). A phylogenetic analysis of approximately 3.4 kbp of continuous MgGHV sequences encompassing the glycoprotein B gene and DNA polymerase gene revealed that the MgGHV sequences are distinct from those of other reported gammaherpesviruses. Further analysis suggested the existence of co-infections of herpesviruses in Indonesian fruit bats. Our findings extend our understanding of the infectious cycles of herpesviruses in bats in Indonesia and the phylogenetic diversity of the gammaherpesviruses.
[Mh] Termos MeSH primário: Quirópteros/virologia
Gammaherpesvirinae/genética
Gammaherpesvirinae/isolamento & purificação
Infecções por Herpesviridae/veterinária
[Mh] Termos MeSH secundário: Animais
Coinfecção/epidemiologia
Coinfecção/veterinária
Coinfecção/virologia
DNA Viral/genética
Reservatórios de Doenças
Gammaherpesvirinae/classificação
Herpesviridae/genética
Herpesviridae/isolamento & purificação
Infecções por Herpesviridae/epidemiologia
Infecções por Herpesviridae/virologia
Seres Humanos
Indonésia/epidemiologia
Filogenia
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
Proteínas Virais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 0 (Viral Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000689


  2 / 6938 MEDLINE  
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[PMID]:28962967
[Au] Autor:Gao F; Jiang JZ; Wang JY; Wei HY
[Ad] Endereço:Key Laboratory of Aquatic Product Processing, Ministry of Agriculture, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, China; Shanghai Ocean University, Shanghai, 201306, China. Electronic address: tianchengyinuo@163.com.
[Ti] Título:Real-time isothermal detection of Abalone herpes-like virus and red-spotted grouper nervous necrosis virus using recombinase polymerase amplification.
[So] Source:J Virol Methods;251:92-98, 2018 Jan.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Abalone herpes-like virus (AbHV) and Red-spotted grouper nervous necrosis virus (RGNNV) are two serious viruses that infect animal populations in aquaculture. Both viruses cause diseases associated with high mortality rates, resulting in dramatic economic losses in the aquaculture industry. There are currently no effective treatments for either of these two viral diseases. Thus, early, rapid, and accurate diagnosis plays a fundamental role in disease prevention and control in aquaculture. Traditional methods of diagnosis, such as virus culture, enzyme-linked immunoassay, and polymerase chain reaction (PCR), are either time consuming or require sophisticated temperature control devices. In this study, one sets of specific primers and probes were designed for the real-time quantitative recombinase polymerase amplification (qRPA) detection of AbHV and RGNNV separately. The sensitivity and specificity of detection were evaluated by comparison with detection by conventional PCR and quantitative PCR. The optimal reaction temperature and time for virus detection is 37°C for 20min. The detection limit is 100 copies per reaction, making this approach faster and more sensitive than qPCR in this study. In a field application, the detection percentage of qRPA was higher than that of qPCR for both AbHV and NNV. Additionally, good correlation was found between qRPA and qPCR detection (R >0.8). The methods presented here can be used as alternatives to qPCR for quick and quantitative detection of pathogens infecting aquaculture species.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/veterinária
Herpesviridae/isolamento & purificação
Técnicas de Diagnóstico Molecular/métodos
Nodaviridae/isolamento & purificação
Técnicas de Amplificação de Ácido Nucleico/métodos
Infecções por Vírus de RNA/veterinária
[Mh] Termos MeSH secundário: Animais
Aquicultura
Infecções por Vírus de DNA/diagnóstico
Peixes
Gastrópodes
Herpesviridae/genética
Nodaviridae/genética
Infecções por Vírus de RNA/diagnóstico
Sensibilidade e Especificidade
Medicina Veterinária/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171001
[St] Status:MEDLINE


  3 / 6938 MEDLINE  
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[PMID]:27771562
[Au] Autor:Reed A; Lin L; Ostertag-Hill C; Wang Q; Wu Z; Miller-Morgan T; Jin L
[Ad] Endereço:Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University Corvallis, OR 97331, USA; Department of Microbiology, College of Science, Oregon State University, Corvallis, OR 97331, USA.
[Ti] Título:Detection of ORF6 protein associated with latent KHV infection.
[So] Source:Virology;500:82-90, 2017 01.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Koi herpesvirus (KHV) is highly pathogenic to Cyprinus carpio. KHV can also become latent in recovered fish and reactivate from latency under stressful conditions. Understanding KHV latency is important for development of strategies against herpesvirus latent infection. Our previous studies found KHV ORF6 mRNA is detectable during latent infection. In this study, ORF6 protein expression was investigated by a polyclonal antibody specific to ORF6 peptide. Positive staining by an immunofluorescence assay was observed in both KHV infected CCB (common carp brain) cells and IgM white blood cells (WBCs) from recovered KHV koi. Proteins at the expected size, 68kDa, and several different sizes can be detected during productive infection. Five potential sumoylation sites were identified in the ORF6 protein. Our study demonstrated that ORF6 protein is expressed in both productive infection and latent infection and may have different post-translational modifications during productive infection.
[Mh] Termos MeSH primário: Carpas/virologia
Doenças dos Peixes/virologia
Infecções por Herpesviridae/veterinária
Herpesviridae/fisiologia
Proteínas Virais/metabolismo
Latência Viral
[Mh] Termos MeSH secundário: Animais
Regulação Viral da Expressão Gênica
Herpesviridae/genética
Infecções por Herpesviridae/virologia
Processamento de Proteína Pós-Traducional
Proteínas Virais/genética
Ativação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  4 / 6938 MEDLINE  
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[PMID]:29045430
[Au] Autor:Jonker I; Schoevers R; Klein H; Rosmalen J
[Ad] Endereço:University of Groningen, University Medical Center Groningen, Department of Psychiatry, Interdisciplinary Center for Psychopathology and Emotion Regulation (ICPE), Groningen, The Netherlands.
[Ti] Título:The association between herpes virus infections and functional somatic symptoms in a general population of adolescents. The TRAILS study.
[So] Source:PLoS One;12(10):e0185608, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: FSS have been suggested to follow activation of the immune system, triggered by herpes virus infections. The aim of this study was to find out whether herpes virus infections were associated with the experience of FSS in adolescents, and whether this association was mediated by hsCRP, as a general marker of immune activation. METHODS: This study was performed in TRAILS, a large prospective population cohort of 2230 adolescents (mean age: 16.1 years, SD = .66, 53.4% girls). FSS were assessed using the somatic complaints subscale of the Youth Self-Report. FSS were analyzed as total scores and divided in two group clusters based on previous studies in this cohort. Levels of hsCRP and antibody levels to the herpes viruses HSV1, HSV2, CMV, EBV and HHV6 were assessed in blood samples at age 16. Also a value for pathogen burden was created adding the number of viruses the adolescents were seropositive for. Multiple regression analysis with bootstrapping was used to analyze the association between viral antibodies and pathogen burden, hsCRP and FSS scores. RESULTS: Antibody levels and pathogen burden were not associated with FSS total scores or FSS scores in both symptom groups. hsCRP was associated with the total FSS score (B = .02, 95% CI: .004 to .028, p = .01) and FSS score in the symptom group of headache and gastrointestinal complaints (B = .02, 95% CI: .001 to .039, p = .04). CONCLUSION: Our study showed no association between herpes virus infections and FSS in general or specific FSS symptom clusters. A role for inflammatory processes in FSS development was supported by the significant association we found between hsCRP levels and FSS, especially in the symptom group of headache and gastrointestinal complaints.
[Mh] Termos MeSH primário: Infecções por Herpesviridae/virologia
Herpesviridae/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Anticorpos Antivirais/imunologia
Proteína C-Reativa/metabolismo
Feminino
Infecções por Herpesviridae/imunologia
Seres Humanos
Masculino
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185608


  5 / 6938 MEDLINE  
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[PMID]:29036216
[Au] Autor:Li F; Zhu C; Deng FY; Wong MCM; Lu HX; Feng XP
[Ad] Endereço:Department of Preventive Dentistry, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
[Ti] Título:Herpesviruses in etiopathogenesis of aggressive periodontitis: A meta-analysis based on case-control studies.
[So] Source:PLoS One;12(10):e0186373, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Previous studies have found that herpesviruses are associated with aggressive periodontitis (AgP). However, these findings are controversial. This meta-analysis was aimed at clarifying the association between herpesviruses and AgP. METHODS: We identified eligible case-control studies evaluating the association between herpesviruses and AgP from PubMed and Embase databases in October 2015. Original data were extracted and quality assessment was done. Overall odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Random-effects model was determined. The stability was evaluated by sensitivity analysis. Finally, Egger's funnel plot was used to investigate the publication bias. RESULTS: Twelve case-control studies involving 322 patients and 342 controls were included in the present meta-analysis. The included case-control studies were assessed as high quality. The quantitative synthesis results for Epstein-Barr virus (EBV) showed significance (10 studies: p = 0.0008, OR = 6.11, 95% CI = 2.13-17.51); nevertheless, evidence of publication bias for EBV was considerable (EBV: Egger's test, p<0.001). Human cytomegalovirus (HCMV) and Herpes simplex virus type 1 (HSV-1) had significant association with AgP (12 studies for HCMV: p = 0.009, OR = 3.63, 95% CI = 2.15-6.13; 4 studies for HSV-1: p<0.001, OR = 19.19, 95% CI = 4.16-79.06). Sensitivity analyses showed the results yielded consistency, and no significant publication bias was observed for HCMV. The association between Herpes simplex virus type 2 (HSV-2) and AgP was inconclusive (2 studies: p = 0.20, OR = 3.46, 95% CI = 0.51-23.51). CONCLUSION: This meta-analysis suggests that HCMV and HSV-1 are significantly associated with AgP. However, due to the heterogeneity among studies these conclusions should be cautiously interpreted. There is insufficient evidence to draw any conclusion between EBV, HSV-2 and AgP based on the currently limited data.
[Mh] Termos MeSH primário: Periodontite Agressiva/etiologia
Periodontite Agressiva/virologia
Herpesviridae/fisiologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186373


  6 / 6938 MEDLINE  
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[PMID]:28985573
[Au] Autor:Bauer D; Keller J; Alt M; Schubert A; Aufderhorst UW; Palapys V; Kasper M; Heilingloh CS; Dittmer U; Laffer B; Eis-Hübinger AM; Verjans GM; Heiligenhaus A; Roggendorf M; Krawczyk A
[Ad] Endereço:Ophtha-Lab, Department of Ophthalmology at St. Franziskus Hospital, Muenster, Germany.
[Ti] Título:Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections.
[So] Source:Virology;512:194-200, 2017 Dec.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The increasing incidence of aciclovir- (ACV) resistant strains in patients with ocular herpes simplex virus (HSV) infections is a major health problem in industrialized countries. In the present study, the humanized monoclonal antibody (mAb) hu2c targeting the HSV-1/2 glycoprotein B was examined for its efficacy towards ACV-resistant infections of the eye in the mouse model of acute retinal necrosis (ARN). BALB/c mice were infected by microinjection of an ACV-resistant clinical isolate into the anterior eye chamber to induce ARN and systemically treated with mAb hu2c at 24h prior (pre-exposure prophylaxis) or at 24, 40, and 56h after infection (post-exposure immunotherapy). Mock treated controls and ACV-treated mice showed pronounced retinal damage. Mice treated with mAb hu2c were almost completely protected from developing ARN. In conclusion, mAb hu2c may become a reliable therapeutic option for drug/ACV-resistant ocular HSV infections in humans in order to prevent blindness.
[Mh] Termos MeSH primário: Aciclovir/farmacologia
Anticorpos Monoclonais/uso terapêutico
Anticorpos Antivirais/imunologia
Herpesviridae/efeitos dos fármacos
Imunoterapia
Retinite/virologia
[Mh] Termos MeSH secundário: Animais
Antivirais/farmacologia
Farmacorresistência Viral
Feminino
Herpesviridae/imunologia
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Retinite/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antibodies, Viral); 0 (Antiviral Agents); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  7 / 6938 MEDLINE  
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[PMID]:28902907
[Au] Autor:Shimada T; Nagata N; Okahara K; Joya A; Hayashida T; Oka S; Sakurai T; Akiyama J; Uemura N; Gatanaga H
[Ad] Endereço:Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo, Japan.
[Ti] Título:PCR detection of human herpesviruses in colonic mucosa of individuals with inflammatory bowel disease: Comparison with individuals with immunocompetency and HIV infection.
[So] Source:PLoS One;12(9):e0184699, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Detection of human herpesviruses (HHVs) other than cytomegalovirus (CMV) in colonic mucosa of individuals with inflammatory bowel disease (IBD) remains unknown. This study identified eight HHVs in the colonic mucosa of individuals with IBD and compared the results with immunocompetent and human immunodeficiency virus (HIV)-infected individuals. METHODS: A total of 89 individuals who had colorectal ulcer on colonoscopy were enrolled: 26 with immunocompetency (n = 26), 41 with IBD, and 22 with HIV infection. We examined the colonic ulcers for the presence of eight HHVs-herpes simplex virus (HSV)-1/2, varicella zoster virus (VZV), CMV, Epstein-Barr virus (EBV), HHV-6, HHV-7, and HHV-8-using mucosal PCR. RESULTS: The IBD group had positivity rates of 0%, 0%, 0%, 53.7%, 24.4%, 39%, 39%, and 0% for HSV-1, HSV-2, VZV, EBV, CMV, HHV-6, HHV-7, and HHV-8, respectively. The positivity rates of EBV and CMV in colonic mucosa increased significantly in the order of the immunocompetent, IBD, and HIV groups (EBV: 23.1%, 53.7%, 72.7%, P for trend = 0.0005; CMV, 7.7%, 24.4%, 54.5%, P for trend = 0.0003, respectively), but no increase was found in the other HHVs. Median mucosal EBV DNA values in the immunocompetent, IBD, and HIV groups were 0, 76, and 287 copies/µg DNA, respectively (P for trend = 0.002). Corresponding median mucosal CMV DNA values were 0, 0, and 17 copies/µg DNA (P for trend = 0.0001). There was no significant difference in the positivity rates of the eight HHVs between ulcerative colitis and Crohn's disease. CONCLUSION: The HHVs of EBV, CMV, HHV-6, and HHV-7, but not of HSV-1, HSV-2, VZV, or HHV-8, were identified in the colonic mucosa of IBD individuals. EBV and CMV in colonic mucosa was correlated with host immune status in increasing order of immunocompetent, IBD, and HIV-infected individuals.
[Mh] Termos MeSH primário: Colo/virologia
Infecções por HIV/virologia
Herpesviridae/genética
Doenças Inflamatórias Intestinais/virologia
[Mh] Termos MeSH secundário: Infecções por HIV/complicações
Herpesviridae/isolamento & purificação
Infecções por Herpesviridae/imunologia
Infecções por Herpesviridae/virologia
Seres Humanos
Imunocompetência
Doenças Inflamatórias Intestinais/complicações
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184699


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[PMID]:28901631
[Au] Autor:Seeber PA; Soilemetzidou SE; East ML; Walzer C; Greenwood AD
[Ad] Endereço:Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
[Ti] Título:Equine behavioral enrichment toys as tools for non-invasive recovery of viral and host DNA.
[So] Source:Zoo Biol;36(5):341-344, 2017 Sep.
[Is] ISSN:1098-2361
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Direct collection of samples from wildlife can be difficult and sometimes impossible. Non-invasive remote sampling for the purpose of DNA extraction is a potential tool for monitoring the presence of wildlife at the individual level, and for identifying the pathogens shed by wildlife. Equine herpesviruses (EHV) are common pathogens of equids that can be fatal if transmitted to other mammals. Transmission usually occurs by nasal aerosol discharge from virus-shedding individuals. The aim of this study was to validate a simple, non-invasive method to track EHV shedding in zebras and to establish an efficient protocol for genotyping individual zebras from environmental DNA (eDNA). A commercially available horse enrichment toy was deployed in captive Grévy's, mountain, and plains zebra enclosures and swabbed after 4-24 hr. Using eDNA extracted from these swabs four EHV strains (EHV-1, EHV-7, wild ass herpesvirus and zebra herpesvirus) were detected by PCR and confirmed by sequencing, and 12 of 16 zebras present in the enclosures were identified as having interacted with the enrichment toy by mitochondrial DNA amplification and sequencing. We conclude that, when direct sampling is difficult or prohibited, non-invasive sampling of eDNA can be a useful tool to determine the genetics of individuals or populations and for detecting pathogen shedding in captive wildlife.
[Mh] Termos MeSH primário: Criação de Animais Domésticos/instrumentação
DNA Viral/isolamento & purificação
Equidae/virologia
Herpesviridae/genética
Jogos e Brinquedos
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Feminino
Herpesviridae/classificação
Herpesviridae/isolamento & purificação
Masculino
Eliminação de Partículas Virais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1002/zoo.21380


  9 / 6938 MEDLINE  
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[PMID]:28886381
[Au] Autor:Ribas A; Dummer R; Puzanov I; VanderWalde A; Andtbacka RHI; Michielin O; Olszanski AJ; Malvehy J; Cebon J; Fernandez E; Kirkwood JM; Gajewski TF; Chen L; Gorski KS; Anderson AA; Diede SJ; Lassman ME; Gansert J; Hodi FS; Long GV
[Ad] Endereço:University of California at Los Angeles, Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA. Electronic address: aribas@mednet.ucla.edu.
[Ti] Título:Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy.
[So] Source:Cell;170(6):1109-1119.e10, 2017 Sep 07.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Here we report a phase 1b clinical trial testing the impact of oncolytic virotherapy with talimogene laherparepvec on cytotoxic T cell infiltration and therapeutic efficacy of the anti-PD-1 antibody pembrolizumab. Twenty-one patients with advanced melanoma were treated with talimogene laherparepvec followed by combination therapy with pembrolizumab. Therapy was generally well tolerated, with fatigue, fevers, and chills as the most common adverse events. No dose-limiting toxicities occurred. Confirmed objective response rate was 62%, with a complete response rate of 33% per immune-related response criteria. Patients who responded to combination therapy had increased CD8 T cells, elevated PD-L1 protein expression, as well as IFN-γ gene expression on several cell subsets in tumors after talimogene laherparepvec treatment. Response to combination therapy did not appear to be associated with baseline CD8 T cell infiltration or baseline IFN-γ signature. These findings suggest that oncolytic virotherapy may improve the efficacy of anti-PD-1 therapy by changing the tumor microenvironment. VIDEO ABSTRACT.
[Mh] Termos MeSH primário: Anticorpos Monoclonais Humanizados/administração & dosagem
Melanoma/terapia
Terapia Viral Oncolítica/efeitos adversos
[Mh] Termos MeSH secundário: Terapia Combinada
Herpesviridae/genética
Seres Humanos
Imunoterapia
Receptor de Morte Celular Programada 1/antagonistas & inibidores
Microambiente Tumoral
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal, Humanized); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); DPT0O3T46P (pembrolizumab)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE


  10 / 6938 MEDLINE  
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[PMID]:28848041
[Au] Autor:Pontejo SM; Murphy PM
[Ad] Endereço:Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
[Ti] Título:Chemokines encoded by herpesviruses.
[So] Source:J Leukoc Biol;102(5):1199-1217, 2017 Nov.
[Is] ISSN:1938-3673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Viruses use diverse strategies to elude the immune system, including copying and repurposing host cytokine and cytokine receptor genes. For herpesviruses, the chemokine system of chemotactic cytokines and receptors is a common source of copied genes. Here, we review the current state of knowledge about herpesvirus-encoded chemokines and discuss their possible roles in viral pathogenesis, as well as their clinical potential as novel anti-inflammatory agents or targets for new antiviral strategies.
[Mh] Termos MeSH primário: Quimiocinas/imunologia
Infecções por Herpesviridae/virologia
Herpesviridae/imunologia
Evasão da Resposta Imune
Receptores de Quimiocinas/imunologia
[Mh] Termos MeSH secundário: Animais
Quimiocinas/classificação
Quimiocinas/genética
Células Dendríticas/imunologia
Células Dendríticas/virologia
Regulação da Expressão Gênica
Herpesviridae/classificação
Herpesviridae/crescimento & desenvolvimento
Infecções por Herpesviridae/classificação
Infecções por Herpesviridae/genética
Infecções por Herpesviridae/imunologia
Seres Humanos
Monócitos/imunologia
Monócitos/virologia
Filogenia
Receptores de Quimiocinas/classificação
Receptores de Quimiocinas/genética
Transdução de Sinais
Linfócitos T/imunologia
Linfócitos T/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Chemokines); 0 (Receptors, Chemokine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171117
[Lr] Data última revisão:
171117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1189/jlb.4RU0417-145RR



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