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[PMID]:28783746
[Au] Autor:Katz D; Shi W; Gowda MS; Vasireddi M; Patrusheva I; Seoh HK; Filfili CN; Wildes MJ; Oh J; Hilliard JK
[Ad] Endereço:Department of Biology, Viral Immunology Center, Georgia State University, Atlanta Georgia, United States of America.
[Ti] Título:Identification of unique B virus (Macacine Herpesvirus 1) epitopes of zoonotic and macaque isolates using monoclonal antibodies.
[So] Source:PLoS One;12(8):e0182355, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Our overall aim is to develop epitope-based assays for accurate differential diagnosis of B virus zoonotic infections in humans. Antibodies to cross-reacting epitopes on human-simplexviruses continue to confound the interpretation of current assays where abundant antibodies exist from previous infections with HSV types 1 and 2. To find B virus-specific epitopes we cloned ten monoclonal antibodies (mAbs) from the hybridomas we produced. Our unique collection of rare human sera from symptomatic and asymptomatic patients infected with B virus was key to the evaluation and identification of the mAbs as reagents in competition ELISAs (mAb-CE). The analysis of the ten mAbs revealed that the target proteins for six mAbs was glycoprotein B of which two are reactive to simian simplexviruses and not to human simplexviruses. Two mAbs reacted specifically with B virus glycoprotein D, and two other mAbs were specific to VP13/14 and gE-gI complex respectively. The mAbs specific to VP13/14 and gE-gI are strain specific reacting with B virus isolates from rhesus and Japanese macaques and not with isolates from cynomolgus and pigtail macaques. The mAb-CE revealed that a high proportion of naturally B virus infected rhesus macaques and two symptomatic humans possess antibodies to epitopes of VP13/14 protein and on the gE-gI complex. The majority of sera from B virus infected macaques and simplexvirus-infected humans competed with the less specific mAbs. These experiments produced a novel panel of mAbs that enabled B virus strain identification and confirmation of B virus infected macaques by the mAb-CE. For human sera the mAb-CE could be used only for selected cases due to the selective B virus strain-specificity of the mAbs against VP13/14 and gE/gI. To fully accomplish our aim to provide reagents for unequivocal differential diagnosis of zoonotic B virus infections, additional mAbs with a broader range of specificities is critical.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/imunologia
Epitopos/imunologia
Herpesvirus Cercopitecino 1/imunologia
Herpesvirus Cercopitecino 1/isolamento & purificação
Zoonoses/virologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Macaca fascicularis
Macaca mulatta
Camundongos
Proteínas Recombinantes/imunologia
Proteínas do Envelope Viral/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Epitopes); 0 (Recombinant Proteins); 0 (Viral Envelope Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182355


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[PMID]:28558072
[Au] Autor:Vasireddi M; Hilliard JK
[Ad] Endereço:Viral Immunology Center, Biology Department, Georgia State University, Atlanta, GA, United States of America.
[Ti] Título:Regulation of PI3K/Akt dependent apoptotic markers during b virus infection of human and macaque fibroblasts.
[So] Source:PLoS One;12(5):e0178314, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:B virus (Macacine herpesvirus 1), a simplex virus endemic in macaques, causes encephalitis, encephalomyelitis, and death in 80% of untreated zoonotically infected humans with delayed or no treatment. Here we report a significant difference in PI3K/Akt-dependent apoptosis between B virus infected human and macaque dermal fibroblasts. Our data show that B virus infection in either human or macaque fibroblasts results in activation of Akt via PI3K and this activation does not require viral de novo protein synthesis. Inhibition of PI3K with LY294002 results in a significant reduction of viral titers in B virus infected macaque and human fibroblasts with only a modest difference in the reduction of virus titers between the two cell types. We, therefore, tested the hypothesis that B virus results in the phosphorylation of Akt (S473), which prevents apoptosis, enhancing virus replication in B virus infected macaque dermal fibroblasts. We observed markers of intrinsic apoptosis when PI3K activation of Akt was inhibited in B virus infected macaque cells, while, these apoptotic markers were absent in B virus infected human fibroblasts under the same conditions. From these data we suggest that PI3K activates Akt in B virus infected macaque and human fibroblasts, but this enhances virus replication in macaque fibroblast cells by blocking apoptosis.
[Mh] Termos MeSH primário: Apoptose
Herpesvirus Cercopitecino 1/patogenicidade
Fosfatidilinositol 3-Quinases/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
[Mh] Termos MeSH secundário: Animais
Fibroblastos/virologia
Seres Humanos
Macaca
Fosforilação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178314


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[PMID]:27720945
[Au] Autor:Akaishi Y; Matsumoto T; Harada Y; Hirayama Y
[Ad] Endereço:Department of Primary Care and General Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. Electronic address: osuishi@tokyo-med.ac.jp.
[Ti] Título:Evaluation of the rapid influenza detection tests GOLD SIGN FLU and Quick Navi-Flu for the detection of influenza A and B virus antigens in adults during the influenza season.
[So] Source:Int J Infect Dis;52:55-58, 2016 Nov.
[Is] ISSN:1878-3511
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:As the characteristics and accuracy of rapid influenza detection tests (RIDTs) vary, the development of a high-performance RIDT has been eagerly anticipated. In this study, the new RIDT GOLD SIGN FLU and the existing RIDT Quick Navi-Flu were evaluated in terms of detecting the antigens of influenza viruses A and B in Japanese adults with influenza-like symptoms. The study was performed from December 2013 to March 2014. Among the 123 patients from whom nasopharyngeal swab specimens were collected, 59 tested positive by viral isolation as the gold standard method (influenza A, n=38; influenza B, n=21). For GOLD SIGN FLU, the sensitivities were 73.7% and 81.0%, and the specificities were 97.6% and 98.0% for influenza A and B, respectively. For Quick Navi-Flu, the sensitivities were 86.8% and 85.7%, and the specificities were 98.8% and 100% for influenza A and B, respectively. The time to the appearance of the line on the test strip was less than 3min for influenza A and less than 2min for influenza B with both RIDTs in more than 90% of cases. GOLD SIGN FLU was useful for diagnosing influenza A, and the result was readily available for influenza B particularly among adult patients. Quick Navi-Flu showed better sensitivities and specificities than GOLD SIGN FLU.
[Mh] Termos MeSH primário: Antígenos Virais/sangue
Imunocromatografia/métodos
Influenza Humana/virologia
Orthomyxoviridae/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Antígenos Virais/imunologia
Feminino
Herpesvirus Cercopitecino 1
Seres Humanos
Vírus da Influenza B/isolamento & purificação
Masculino
Meia-Idade
Tempo de Protrombina
Estações do Ano
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Viral)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


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[PMID]:27512063
[Au] Autor:Patrusheva I; Perelygina L; Torshin I; LeCher J; Hilliard J
[Ad] Endereço:Viral Immunology Center, Department of Biology, Georgia State University, Atlanta, Georgia, USA.
[Ti] Título:B Virus (Macacine Herpesvirus 1) Divergence: Variations in Glycoprotein D from Clinical and Laboratory Isolates Diversify Virus Entry Strategies.
[So] Source:J Virol;90(20):9420-32, 2016 Oct 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: B virus (Macacine herpesvirus 1) can cause deadly zoonotic disease in humans. Molecular mechanisms of B virus cell entry are poorly understood for both macaques and humans. Here we investigated the abilities of clinical B virus isolates to use entry receptors of herpes simplex viruses (HSV). We showed that resistant B78H1 cells became susceptible to B virus clinical strains upon expression of either human nectin-2 or nectin-1. Antibody against glycoprotein D (gD) protected these nectin-bearing cells from B virus infection, and a gD-negative recombinant B virus failed to enter these cells, indicating that the nectin-mediated B virus entry depends on gD. We observed that the infectivity of B virus isolates with a single amino acid substitution (D122N) in the IgV-core of the gD ectodomain was impaired on nectin-1-bearing cells. Computational homology-based modeling of the B virus gD-nectin-1 complex revealed conformational differences between the structures of the gD-122N and gD-122D variants that affected the gD-nectin-1 protein-protein interface and binding affinity. Unlike HSV, B virus clinical strains were unable to use herpesvirus entry mediator (HVEM) as a receptor, regardless of conservation of the gD amino acid residues essential for HSV-1 entry via HVEM. Based on the model of the B virus gD-HVEM interface, we predict that residues R7, R11, and G15 are largely responsible for the inability of B virus to utilize HVEM for entry. The ability of B virus to enter cells of a human host by using a combination of receptors distinct from those for HSV-1 or HSV-2 suggests a possible mechanism of enhanced neuropathogenicity associated with zoonotic infections. IMPORTANCE: B virus causes brainstem destruction in infected humans in the absence of timely diagnosis and intervention. Nectins are cell adhesion molecules that are widely expressed in human tissues, including neurons and neuronal synapses. Here we report that human nectin-2 is a target receptor for B virus entry, in addition to the reported receptor human nectin-1. Similar to a B virus lab strain, B virus clinical strains can effectively use both nectin-1 and nectin-2 as cellular receptors for entry into human cells, but unlike HSV-1 and HSV-2, none of the clinical strains uses an HVEM-mediated entry pathway. Ultimately, these differences between B virus and HSV-1 and -2 may provide insight into the neuropathogenicity of B virus during zoonotic infections.
[Mh] Termos MeSH primário: Variação Genética/genética
Infecções por Herpesviridae/virologia
Herpesvirus Cercopitecino 1/genética
Proteínas do Envelope Viral/genética
[Mh] Termos MeSH secundário: Substituição de Aminoácidos/genética
Animais
Moléculas de Adesão Celular/metabolismo
Cercopithecus aethiops
Infecções por Herpesviridae/metabolismo
Herpesvirus Cercopitecino 1/metabolismo
Herpesvirus Humano 1/genética
Herpesvirus Humano 1/metabolismo
Herpesvirus Humano 2/genética
Herpesvirus Humano 2/metabolismo
Seres Humanos
Camundongos
Nectinas
Membro 14 de Receptores do Fator de Necrose Tumoral/genética
Membro 14 de Receptores do Fator de Necrose Tumoral/metabolismo
Receptores Virais/metabolismo
Células Vero
Proteínas do Envelope Viral/metabolismo
Internalização do Vírus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Adhesion Molecules); 0 (NECTIN1 protein, human); 0 (Nectin1 protein, mouse); 0 (Nectins); 0 (Receptors, Tumor Necrosis Factor, Member 14); 0 (Receptors, Virus); 0 (Viral Envelope Proteins); 0 (glycoprotein D, Human herpesvirus 1)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160812
[St] Status:MEDLINE
[do] DOI:10.1128/JVI.00799-16


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[PMID]:27294502
[Au] Autor:Gleeson M; Bishop NC; Struszczak L
[Ad] Endereço:School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, LE12 3TU, UK. m.gleeson@lboro.ac.uk.
[Ti] Título:Effects of Lactobacillus casei Shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial.
[So] Source:Eur J Appl Physiol;116(8):1555-63, 2016 Aug.
[Is] ISSN:1439-6327
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:AIMS: To assess evidence of health and immune benefit by consumption of a Lactobacillus casei Shirota probiotic in highly physically active people. METHODS: Single-centre, population-based, randomized, double-blind, placebo-controlled trial. Daily ingestion of probiotic (PRO) or placebo (PLA) for 20 weeks for n = 243 (126 PRO, 117 PLA) university athletes and games players. Subjects completed validated questionnaires on upper respiratory tract infection symptoms (URS) on a daily basis and on physical activity status at weekly intervals during the intervention period. Blood samples were collected before and after 20 weeks of the intervention for determination of Epstein Barr virus (EBV) and cytomegalovirus (CMV) serostatus and antibody levels. RESULTS: URS episode incidence was unexpectedly low (mean 0.6 per individual) and was not significantly different on PRO compared with PLA. URS episode duration and severity were also not influenced by PRO. A significant time × group interaction effect was observed for plasma CMV antibody titres in CMV seropositive participants (p < 0.01) with antibody titre falling in the PRO group but remaining unchanged in the PLA group over time. A similar effect was found for plasma EBV antibody titres in EBV seropositive participants (p < 0.01) with antibody titre falling in the PRO group but increasing in the PLA group over time. CONCLUSIONS: In summary, regular ingestion of PRO did not reduce URS episode incidence which might be attributable to the low URS incidence in this study. Regular ingestion of PRO reduced plasma CMV and EBV antibody titres, an effect that can be interpreted as a benefit to overall immune status.
[Mh] Termos MeSH primário: Lactobacillus casei
Probióticos/uso terapêutico
Infecções Respiratórias/epidemiologia
Infecções Respiratórias/prevenção & controle
Infecções Respiratórias/virologia
Esportes/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Anticorpos Antivirais/sangue
Anticorpos Antivirais/imunologia
Resfriado Comum/epidemiologia
Resfriado Comum/prevenção & controle
Resfriado Comum/virologia
Método Duplo-Cego
Feminino
Herpesvirus Cercopitecino 1/isolamento & purificação
Seres Humanos
Masculino
Resistência Física
Efeito Placebo
Resultado do Tratamento
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160614
[St] Status:MEDLINE
[do] DOI:10.1007/s00421-016-3415-x


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[PMID]:27053570
[Au] Autor:Gulani J; Koch A; Chappell MG; Christensen CL; Facemire P; Singh VK; Ossetrova NI; Srinivasan V; Holt RK
[Ad] Endereço:Veterinary Science Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
[Ti] Título:Cercopithecine Herpesvirus 9 (Simian Varicella Virus) Infection after Total-Body Irradiation in a Rhesus Macaque (Macaca mulatta).
[So] Source:Comp Med;66(2):150-3, 2016 Apr.
[Is] ISSN:1532-0820
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This case report describes a rhesus macaque (Macaca mulatta; male; age, 5 y; weight, 6.7 kg) with anorexia, dehydration, lethargy, ataxia, and generalized skin rashes that occurred 30 d after total-body irradiation at 6.5 Gy ((60)Co γ-rays). Physical examination revealed pale mucus membranes, a capillary refill time of 4 s, heart rate of 180 bpm. and respirations at 50 breaths per minute. Diffuse multifocal maculopapulovesicular rashes were present on the body, including mucocutaneous junctions. The CBC analysis revealed a Hct of 48%, RBC count of 6.2 × 10(6)/µL, platelet count of 44 × 10(3)/µL, and WBC count of 25 × 10(3)/µL of WBC. The macaque was euthanized in light of a grave prognosis. Gross examination revealed white foci on the liver, multifocal generalized petechiation on serosal and mucosal surfaces of the gastrointestinal tract, hemorrhagic lymph nodes, and hemorrhagic fluid in the thoracic cavity. Microscopic examination revealed cutaneous vesicular lesions with intranuclear eosinophilic viral inclusions within the epithelial cells, consistent with herpesvirus. Immunohistochemistry was positive for herpesvirus. The serum sample was negative for antibodies against Macacine herpesvirus 1 and Cercopithecine herpesvirus 9 (simian varicella virus, SVV). Samples submitted for PCR-based identification of the etiologic agent confirmed the presence of SVV DNA. PCR analysis, immunohistochemistry, and histology confirmed that lesions were attributed to an active SVV infection in this macaque. This case illustrates the importance of screening for SVV in rhesus macaques, especially those used in studies that involve immunosuppressive procedures.
[Mh] Termos MeSH primário: Infecções por Herpesviridae/veterinária
Herpesvirus Cercopitecino 1/efeitos da radiação
Macaca mulatta
Doenças dos Macacos/patologia
Irradiação Corporal Total/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Infecções por Herpesviridae/patologia
Infecções por Herpesviridae/virologia
Imuno-Histoquímica
Macaca mulatta/virologia
Masculino
Doenças dos Macacos/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160408
[St] Status:MEDLINE


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[PMID]:26932456
[Au] Autor:Yee JL; Vanderford TH; Didier ES; Gray S; Lewis A; Roberts J; Taylor K; Bohm RP
[Ad] Endereço:California National Primate Research Center, University of California, Davis, CA, USA.
[Ti] Título:Specific pathogen free macaque colonies: a review of principles and recent advances for viral testing and colony management.
[So] Source:J Med Primatol;45(2):55-78, 2016 Apr.
[Is] ISSN:1600-0684
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Specific pathogen free (SPF) macaques provide valuable animal models for biomedical research. In 1989, the National Center for Research Resources [now Office of Research Infrastructure Programs (ORIP)] of the National Institutes of Health initiated experimental research contracts to establish and maintain SPF colonies. The derivation and maintenance of SPF macaque colonies is a complex undertaking requiring knowledge of the biology of the agents for exclusion and normal physiology and behavior of macaques, application of the latest diagnostic technology, facilitiy management, and animal husbandry. This review provides information on the biology of the four viral agents targeted for exclusion in ORIP SPF macaque colonies, describes current state-of-the-art viral diagnostic algorithms, presents data from proficiency testing of diagnostic assays between laboratories at institutions participating in the ORIP SPF program, and outlines management strategies for maintaining the integrity of SPF colonies using results of diagnostic testing as a guide to decision making.
[Mh] Termos MeSH primário: Macaca
Doenças dos Macacos/diagnóstico
Viroses/veterinária
[Mh] Termos MeSH secundário: Algoritmos
Animais
Betaretrovirus/isolamento & purificação
Infecções por Deltaretrovirus/diagnóstico
Infecções por Deltaretrovirus/veterinária
Infecções por Herpesviridae/diagnóstico
Infecções por Herpesviridae/veterinária
Herpesvirus Cercopitecino 1/isolamento & purificação
Modelos Animais
Doenças dos Macacos/virologia
Controle de Qualidade
Infecções por Retroviridae/diagnóstico
Infecções por Retroviridae/veterinária
Síndrome de Imunodeficiência Adquirida dos Símios/diagnóstico
Vírus da Imunodeficiência Símia/isolamento & purificação
Vírus 1 Linfotrópico T de Símios/isolamento & purificação
Organismos Livres de Patógenos Específicos
Viroses/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160303
[St] Status:MEDLINE
[do] DOI:10.1111/jmp.12209


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[PMID]:26563968
[Au] Autor:Rohrman M
[Ad] Endereço:University of Chicago Medicine michele.rohrman@uchospitals.edu.
[Ti] Título:Macacine Herpes Virus (B Virus).
[So] Source:Workplace Health Saf;64(1):9-12, 2016 Jan.
[Is] ISSN:2165-0969
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:B virus is endemic in macaque monkeys, which are frequently used for research studies. B virus is a risk for every employee working with macaque monkeys, their tissues or cells. Although the risk for B virus infection is low, the risk of death or permanent neurological deficit is high if an exposure is not promptly evaluated and treated. Researcher training, routine use of personal protective equipment, first aid protocols, and prompt reporting to a provider knowledgeable about B virus treatment are essential to prevent this 70% lethal infection in untreated humans. This article presents the history and pathogenesis of B virus, first aid, treatment, and prevention.
[Mh] Termos MeSH primário: Pesquisa Biomédica
Infecções por Herpesviridae/diagnóstico
Infecções por Herpesviridae/terapia
Herpesvirus Cercopitecino 1
Doenças Profissionais/diagnóstico
Doenças Profissionais/terapia
[Mh] Termos MeSH secundário: Animais
Infecções por Herpesviridae/etiologia
Seres Humanos
Macaca
Doenças Profissionais/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:151114
[St] Status:MEDLINE
[do] DOI:10.1177/2165079915608857


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[PMID]:26281802
[Au] Autor:Johnston WF; Yeh J; Nierenberg R; Procopio G
[Ad] Endereço:Emergency Trauma Department, Hackensack University Medical Center, Hackensack, New Jersey.
[Ti] Título:Exposure to Macaque Monkey Bite.
[So] Source:J Emerg Med;49(5):634-7, 2015 Nov.
[Is] ISSN:0736-4679
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The herpes B virus is a zoonotic agent that is endemic among macaque monkeys only, but can cause fatal encephalomyelitis in humans. CASE REPORT: A 26-year-old female presented to a U.S. emergency department after being bitten by a wild macaque monkey. The emergency medicine team administered rabies immunoglobulin and rabies vaccine. The team also prescribed acyclovir for prophylactic coverage against herpes B, a deadly zoonotic agent that is endemic among macaque monkeys. A discussion of background, exposure, transmission, symptoms, treatment for herpes B, including latest data available, literature, and Centers for Disease Control and Prevention guidelines are included. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Zoonotic exposures can cause infectious diseases, which are unfamiliar and deadly. The emergency physician's knowledge of the association between the deadly herpes B infection and wild macaque monkey may expedite treatment and be instrumental in patient morbidity and survival.
[Mh] Termos MeSH primário: Mordeduras e Picadas/terapia
Infecções por Herpesviridae/prevenção & controle
Herpesvirus Cercopitecino 1
Macaca
Raiva/prevenção & controle
[Mh] Termos MeSH secundário: Aciclovir/uso terapêutico
Adulto
Animais
Antivirais/uso terapêutico
Mordeduras e Picadas/complicações
Feminino
Seres Humanos
Guias de Prática Clínica como Assunto
Vacinas Antirrábicas/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Rabies Vaccines); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151104
[Lr] Data última revisão:
151104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150819
[St] Status:MEDLINE


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[PMID]:26080081
[Au] Autor:Lee MH; Rostal MK; Hughes T; Sitam F; Lee CY; Japning J; Harden ME; Griffiths A; Basir M; Wolfe ND; Epstein JH; Daszak P
[Ti] Título:Macacine Herpesvirus 1 in Long-Tailed Macaques, Malaysia, 2009-2011.
[So] Source:Emerg Infect Dis;21(7):1107-13, 2015 Jul.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Macacine herpesvirus 1 (MaHV1; B virus) naturally infects macaques (Macaca spp.) and can cause fatal encephalitis in humans. In Peninsular Malaysia, wild macaques are abundant, and translocation is used to mitigate human-macaque conflict. Most adult macaques are infected with MaHV1, although the risk for transmission to persons who handle them during capture and translocation is unknown. We investigated MaHV1 shedding among 392 long-tailed macaques (M. fascicularis) after capture and translocation by the Department of Wildlife and National Parks in Peninsular Malaysia, during 2009-2011. For detection of MaHV1 DNA, PCR was performed on urogenital and oropharyngeal swab samples. Overall, 39% of macaques were shedding MaHV1 DNA; rates of DNA detection did not differ between sample types. This study demonstrates that MaHV1 was shed by a substantial proportion of macaques after capture and transport and suggests that persons handling macaques under these circumstances might be at risk for exposure to MaHV1.
[Mh] Termos MeSH primário: Infecções por Herpesviridae/veterinária
Herpesvirus Cercopitecino 1/fisiologia
Macaca fascicularis/virologia
Doenças dos Macacos/virologia
[Mh] Termos MeSH secundário: Animais
Feminino
Infecções por Herpesviridae/epidemiologia
Infecções por Herpesviridae/virologia
Malásia/epidemiologia
Masculino
Técnicas de Diagnóstico Molecular
Doenças dos Macacos/epidemiologia
Reação em Cadeia da Polimerase
Prevalência
Eliminação de Partículas Virais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150701
[Lr] Data última revisão:
150701
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150617
[St] Status:MEDLINE
[do] DOI:10.3201/eid2107.140162



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