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[PMID]:28453835
[Au] Autor:Celum C; Hong T; Cent A; Donnell D; Morrow R; Baeten JM; Firnhaber C; Grinsztejn B; Hosseinipour MC; Lalloo U; Nyirenda M; Riviere C; Sanchez J; Santos B; Supparatpinyo K; Hakim J; Kumarasamy N; Campbell TB; ACTG PEARLS/A5175 Team
[Ad] Endereço:Department of Global Health, University of Washington , Seattle, Washington, USA.
[Ti] Título:Herpes Simplex Virus Type 2 Acquisition Among HIV-1-Infected Adults Treated With Tenofovir Disoproxyl Fumarate as Part of Combination Antiretroviral Therapy: Results From the ACTG A5175 PEARLS Study.
[So] Source:J Infect Dis;215(6):907-910, 2017 03 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Objective: Tenofovir disoproxyl fumarate (TDF) disoproxyl fumarate (TDF) has in vitro activity against herpes simplex virus type 2 (HSV-2) and reduced HSV-2 acquisition as preexposure prophylaxis. Whether TDF-containing antiretroviral therapy (ART) reduces HSV-2 acquisition is unknown. Design: Secondary analysis of AIDS Clinical Trials Group A5175, a randomized, open-label study of 3 ART regimens among 1571 participants. Methods: HSV-2 serostatus was assessed at baseline, at study exit, and before a change in ART regimen. Results: Of 365 HSV-2-seronegative persons, 68 acquired HSV-2, with 24 receiving TDF-containing ART and 44 receiving ART without TDF (HSV-2 seroconversion incidence, 6.42 and 6.63 cases/100 person-years, respectively; hazard ratio, 0.89; 95% confidence interval, .55-1.44). Conclusions: HSV-2 acquisition was not reduced in HIV-infected, HSV-2-uninfected persons during TDF-containing ART.
[Mh] Termos MeSH primário: Antivirais/uso terapêutico
Infecções por HIV/complicações
Herpes Simples/prevenção & controle
Herpesvirus Humano 2/efeitos dos fármacos
Profilaxia Pré-Exposição
Tenofovir/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Infecções por HIV/tratamento farmacológico
HIV-1/efeitos dos fármacos
Seres Humanos
Cooperação Internacional
Masculino
Adesão à Medicação
Meia-Idade
Modelos de Riscos Proporcionais
Soroconversão
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antiviral Agents); 99YXE507IL (Tenofovir)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix029


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[PMID]:29385170
[Au] Autor:Hazel A; Holland Jones J
[Ad] Endereço:Department of Earth System Science, Stanford University, Stanford, California, United States of America.
[Ti] Título:Remoteness influences access to sexual partners and drives patterns of viral sexually transmitted infection prevalence among nomadic pastoralists.
[So] Source:PLoS One;13(1):e0191168, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sexually transmitted infections (STIs) comprise a significant portion of the infectious-disease burden among rural people in the Global South. Particular characteristics of ruralness-low-density settlements and poor infrastructure-make healthcare provision difficult, and remoteness, typically a characteristic of ruralness, often compounds the difficultly. Remoteness may also accelerate STI transmission, particularly that of viral STIs, through formation of small, highly connected sexual networks through which pathogens can spread rapidly, especially when partner concurrency is broadly accepted. Herein, we explored the effect of remoteness on herpes simplex virus type-2 (HSV-2) epidemiology among semi-nomadic pastoralists in northwestern (Kaokoveld) Namibia, where, in 2009 we collected HSV-2-specific antibody status, demographic, sexual network, and travel data from 446 subjects (women = 213, men = 233) in a cross-sectional study design. HSV-2 prevalence was high overall in Kaokoveld (>35%), but was heterogeneously distributed across locally defined residential regions: some regions had significantly higher HSV-2 prevalence (39-48%) than others (21-33%). Using log-linear models, we asked the following questions: 1) Are sexual contacts among people in high HSV-2-prevalence regions more likely to be homophilous (i.e., from the same region) than those among people from low-prevalence regions? 2) Are high-prevalence regions more "functionally" remote, in that people from those regions are more likely to travel within their own region than outside, compared to people from other regions? We found that high-prevalence regions were more sexually homophilous than low-prevalence regions and that those regions also had higher rates of within-region travel than the other regions. These findings indicate that remoteness can create contact structures for accelerated STI transmission among people who are already disproportionately vulnerable to consequences of untreated STIs.
[Mh] Termos MeSH primário: Parceiros Sexuais
Doenças Virais Sexualmente Transmissíveis/epidemiologia
Migrantes
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Herpes Genital/epidemiologia
Herpesvirus Humano 2
Seres Humanos
Modelos Lineares
Masculino
Meia-Idade
Namíbia/epidemiologia
Prevalência
População Rural
Comportamento Sexual
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191168


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[PMID]:27772619
[Au] Autor:Abad CL; Razonable RR
[Ad] Endereço:Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN.
[Ti] Título:α Herpes Virus Infections Among Renal Transplant Recipients.
[So] Source:Semin Nephrol;36(5):344-350, 2016 09.
[Is] ISSN:1558-4488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The α herpes viruses HSV-1, HSV-2, and VZV often reactivate in the setting of immune suppression after solid organ transplantation. Oral or genital mucocutaneous disease is the most common clinical manifestation of HSV disease while VZV manifests as varicella (or chickenpox) or reactivation herpes zoster, characterized by a diffuse rash, or a painful unilateral vesicular eruption in a dermatomal distribution, respectively. The diagnosis of HSV and VZV is primarily based on history and clinical presentation, although diagnostic tests may be necessary for atypical presentations of disease. Treatment usually involves oral or intravenous antiviral therapy, depending on severity of illness.
[Mh] Termos MeSH primário: Varicela/induzido quimicamente
Rejeição de Enxerto/prevenção & controle
Herpes Simples/induzido quimicamente
Herpes Zoster/induzido quimicamente
Imunossupressores/efeitos adversos
Falência Renal Crônica/cirurgia
Transplante de Rim
[Mh] Termos MeSH secundário: Antivirais/uso terapêutico
Varicela/diagnóstico
Varicela/tratamento farmacológico
Varicela/prevenção & controle
Vacina contra Varicela/uso terapêutico
Técnicas de Cultura
Técnica Direta de Fluorescência para Anticorpo
Herpes Simples/diagnóstico
Herpes Simples/tratamento farmacológico
Herpes Zoster/diagnóstico
Herpes Zoster/tratamento farmacológico
Herpes Zoster/prevenção & controle
Herpesvirus Humano 1
Herpesvirus Humano 2
Herpesvirus Humano 3
Seres Humanos
Reação em Cadeia da Polimerase
Testes Sorológicos
Ativação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Chickenpox Vaccine); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  4 / 3952 MEDLINE  
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[PMID]:27771977
[Au] Autor:Young S; Body B; Moore F; Dunbar S
[Ad] Endereço:a TriCore Reference Laboratories , Research and Clinical Trials , Albuquerque , NM , USA.
[Ti] Título:Multicenter evaluation of the Luminex® ARIES® HSV 1&2 Assay for the detection of herpes simplex virus types 1 and 2 in cutaneous and mucocutaneous lesion specimens.
[So] Source:Expert Rev Mol Diagn;16(12):1241-1249, 2016 12.
[Is] ISSN:1744-8352
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The ARIES® HSV 1&2 Assay is a new FDA cleared real-time PCR test for detection and differentiation of HSV-1 and HSV-2 DNA from cutaneous and mucocutaneous lesions. The test is performed on the ARIES® System, an automated sample to answer real-time PCR instrument that provides a closed system and simple workflow for performing molecular testing. Areas covered: This article reports the clinical performance of the ARIES® HSV 1&2 Assay assessed on 1963 prospectively collected specimens. Assay sensitivities were 91.1-95% (cutaneous) and 97-98.5% (mucocutaneous), and specificities were 88.8-94.2% (cutaneous) and 93.2-95.4% (mucocutaneous), as compared to the ELVIS® HSV test system. Expert commentary: Detection of HSV DNA by PCR is rapid and more sensitive than traditional culture and immunoassay methods and is being widely adopted in many laboratory settings. Sample to answer molecular platforms like ARIES® will enable routine and non-molecular labs to perform sensitive and rapid molecular testing with ease.
[Mh] Termos MeSH primário: Herpes Simples/diagnóstico
Herpes Simples/virologia
Herpesvirus Humano 1/genética
Herpesvirus Humano 2/genética
Reação em Cadeia da Polimerase em Tempo Real/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
DNA Viral
Feminino
Herpes Genital/diagnóstico
Herpes Genital/virologia
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Técnicas de Amplificação de Ácido Nucleico/métodos
Técnicas de Amplificação de Ácido Nucleico/normas
Reação em Cadeia da Polimerase em Tempo Real/instrumentação
Reação em Cadeia da Polimerase em Tempo Real/normas
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


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[PMID]:29190738
[Au] Autor:McGee D; Smith A; Poncil S; Patterson A; Bernstein AI; Racicot K
[Ad] Endereço:Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America.
[Ti] Título:Cervical HSV-2 infection causes cervical remodeling and increases risk for ascending infection and preterm birth.
[So] Source:PLoS One;12(11):e0188645, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Preterm birth (PTB), or birth before 37 weeks gestation, is the leading cause of neonatal mortality worldwide. Cervical viral infections have been established as risk factors for PTB in women, although the mechanism leading to increased risk is unknown. Using a mouse model of pregnancy, we determined that intra-vaginal HSV2 infection caused increased rates of preterm birth following an intra-vaginal bacterial infection. HSV2 infection resulted in histological changes in the cervix mimicking cervical ripening, including significant collagen remodeling and increased hyaluronic acid synthesis. Viral infection also caused aberrant expression of estrogen and progesterone receptor in the cervical epithelium. Further analysis using human ectocervical cells demonstrated a role for Src kinase in virus-mediated changes in estrogen receptor and hyaluronic acid expression. In conclusion, HSV2 affects proteins involved in tissue hormone responsiveness, causes significant changes reminiscent of premature cervical ripening, and increases risk of preterm birth. Studies such as this improve our chances of identifying clinical interventions in the future.
[Mh] Termos MeSH primário: Medida do Comprimento Cervical
Herpes Genital/patologia
Herpesvirus Humano 2/patogenicidade
Nascimento Prematuro
[Mh] Termos MeSH secundário: Animais
Infecções por Escherichia coli/complicações
Infecções por Escherichia coli/fisiopatologia
Feminino
Herpes Genital/complicações
Herpes Genital/fisiopatologia
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
Modelos Animais
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188645


  6 / 3952 MEDLINE  
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[PMID]:29323854
[Au] Autor:Glukhovets BI; Glukhovets NG; Belitchenko NV; Sosunova OA
[Ti] Título:Immunofluorescence diagnosis of the herpesvirus stillborn infection.
[So] Source:Vopr Virusol;61(5):219-21, 2016.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Congenital herpes infection belongs to the category of actual problems of Perinatal Medicine. Pathological diagnosis of this disease is not effective in the routine method of autopsy studies without virological research. Objective. Determination of the value of the fluorescent antibody technique in the diagnosis of congenital herpes infection of the stillborn is a promising approach to medical diagnosis. subjects and methods. In 96 cases of stillbirth immunofluorescent identification of herpes simplex virus types 1 and 2 and cytomegalovirus in the placenta and internal organs (brain, heart, lungs, and liver) was implemented. The findings were compared with the results of a complete histological examination of the heart, including its rhythmogenic centers. Results. The herpes viruses were found in 51 observations (53.1%). Among them, HSV-1 were found in 16 observations (16.7%), HSV-2, in 19 (19.7%), CMV, in 16 (16.7%). In 34 stillbirths (35.8%) the pathological signs of herpetic atrial myocarditis were observed, which were regarded as the cause of death. Conclusion. The use of the fluorescent antibody technique in the autopsy practice is an effective way of diagnosis of intrauterine infection caused by the herpes simplex virus and cytomegalovirus.
[Mh] Termos MeSH primário: Anticorpos Antivirais/análise
Infecções por Citomegalovirus/diagnóstico
Herpes Genital/diagnóstico
Herpes Simples/diagnóstico
Natimorto
[Mh] Termos MeSH secundário: Adulto
Autopsia
Encéfalo/patologia
Encéfalo/virologia
Citomegalovirus/imunologia
Citomegalovirus/isolamento & purificação
Infecções por Citomegalovirus/mortalidade
Infecções por Citomegalovirus/patologia
Infecções por Citomegalovirus/virologia
Feminino
Imunofluorescência/métodos
Coração/virologia
Herpes Genital/mortalidade
Herpes Genital/patologia
Herpes Genital/virologia
Herpes Simples/mortalidade
Herpes Simples/patologia
Herpes Simples/virologia
Herpesvirus Humano 1/imunologia
Herpesvirus Humano 1/isolamento & purificação
Herpesvirus Humano 2/imunologia
Herpesvirus Humano 2/isolamento & purificação
Seres Humanos
Recém-Nascido
Recém-Nascido Prematuro
Fígado/patologia
Fígado/virologia
Pulmão/patologia
Pulmão/virologia
Masculino
Placenta/patologia
Placenta/virologia
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  7 / 3952 MEDLINE  
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[PMID]:29323845
[Au] Autor:Lazarenko AA; Alimbarova LM; Mordvintseva EY; Barinsky IF
[Ti] Título:Development of the suppository form of human immunoglobulin preparation with high titers of antibodies to herpes simplex virus types 1 and 2 for the treatment of chronic forms of herpetic disease.
[So] Source:Vopr Virusol;62(1):36-41, 2017.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:In spite of the vast arsenal of therapeutic agents, therapy of herpes virus infection (HVI) is very difficult, particularly in pregnant women, newborns and children in the first years of life, as well as in patients with immune deficiency. In this regard, possibility of using immunoglobulins for the treatment of HVI is currently attracting the attention of doctors. The aim of this work was to develop a suppository form of the drug containing donor immunoglobulins with high levels of neutralizing antibodies to herpes simplex virus types 1 and 2 for the treatment of chronic forms of herpetic disease. The study included the following steps: 1) selection of gamma-globulins with high antibody titer for HSV-1 and HSV-2 ELISA test; 2) determination of the level of neutralizing antibodies in the selected series of gamma-globulins in tests in tissue cultures and animals; 3) lyophilization of immunoglobulins; 4) development of the suppository form of the preparation containing gamma-globulin donors with high levels of neutralizing antibodies to HSV-1 and HSV-2; 5) study of the safety of the activity of neutralizing antibodies to HSV-1 and HSV-2 in the suppository form of the drug with hyaluronic acid used as immunomodulator. As the result of this work, immunoglobulin preparation in the suppository form was developed. The developed preparation meets the requirements for safety and efficacy. It is not toxic or pyrogenic. The problems of clinical use of this drug as a method of HVI therapy are discussed.
[Mh] Termos MeSH primário: Anticorpos Neutralizantes/administração & dosagem
Anticorpos Antivirais/administração & dosagem
Herpes Simples/tratamento farmacológico
Herpesvirus Humano 1/imunologia
Herpesvirus Humano 2/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/biossíntese
Anticorpos Neutralizantes/isolamento & purificação
Anticorpos Antivirais/biossíntese
Anticorpos Antivirais/isolamento & purificação
Doença Crônica
Avaliação Pré-Clínica de Medicamentos
Cobaias
Herpes Simples/imunologia
Herpes Simples/virologia
Seres Humanos
Soros Imunes/química
Masculino
Camundongos
Coelhos
Ratos
Supositórios/administração & dosagem
Supositórios/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (Immune Sera); 0 (Suppositories)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


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[PMID]:28916522
[Au] Autor:Cross SN; Potter JA; Aldo P; Kwon JY; Pitruzzello M; Tong M; Guller S; Rothlin CV; Mor G; Abrahams VM
[Ad] Endereço:Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510; and.
[Ti] Título:Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation.
[So] Source:J Immunol;199(8):2885-2895, 2017 Oct 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chorioamnionitis, premature rupture of fetal membranes (FMs), and subsequent preterm birth are associated with local infection and inflammation, particularly IL-1ß production. Although bacterial infections are commonly identified, other microorganisms may play a role in the pathogenesis. Because viral pandemics, such as influenza, Ebola, and Zika, are becoming more common, and pregnant women are at increased risk for associated complications, this study evaluated the impact that viral infection had on human FM innate immune responses. This study shows that a herpes viral infection of FMs sensitizes the tissue to low levels of bacterial LPS, giving rise to an exaggerated IL-1ß response. Using an ex vivo human FM explant system and an in vivo mouse model of pregnancy, we report that the mechanism by which this aggravated inflammation arises is through the inhibition of the TAM receptor, MERTK, and activation of the inflammasome. The TAM receptor ligand, growth arrest specific 6, re-establishes the normal FM response to LPS by restoring and augmenting TAM receptor and ligand expression, as well as by preventing the exacerbated IL-1ß processing and secretion. These findings indicate a novel mechanism by which viruses alter normal FM immune responses to bacteria, potentially giving rise to adverse pregnancy outcomes.
[Mh] Termos MeSH primário: Membranas Extraembrionárias/imunologia
Gammaherpesvirinae/imunologia
Infecções por Herpesviridae/imunologia
Herpesvirus Humano 2/imunologia
Inflamassomos/metabolismo
Nascimento Prematuro/imunologia
Proteínas Proto-Oncogênicas/metabolismo
Receptores Proteína Tirosina Quinases/metabolismo
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Corioamnionite
Feminino
Infecções por Herpesviridae/complicações
Seres Humanos
Imunização
Peptídeos e Proteínas de Sinalização Intercelular/metabolismo
Interleucina-1beta/metabolismo
Lipopolissacarídeos/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Gravidez
Nascimento Prematuro/etiologia
Proteínas Proto-Oncogênicas/genética
Receptores Proteína Tirosina Quinases/genética
c-Mer Tirosina Quinase
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Inflammasomes); 0 (Intercellular Signaling Peptides and Proteins); 0 (Interleukin-1beta); 0 (Lipopolysaccharides); 0 (Proto-Oncogene Proteins); 0 (growth arrest-specific protein 6); EC 2.7.10.1 (MERTK protein, human); EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (c-Mer Tyrosine Kinase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700870


  9 / 3952 MEDLINE  
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[PMID]:28893956
[Au] Autor:Eriksson K; Svensson A; Hait AS; Schlüter K; Tunbäck P; Nordström I; Padyukov L; Liljeqvist JÅ; Mogensen TH; Paludan SR
[Ad] Endereço:Department of Rheumatology and Inflammation Research, University of Gothenburg, 40530 Gothenburg, Sweden.
[Ti] Título:Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-ß Expression.
[So] Source:J Immunol;199(8):2613-2617, 2017 Oct 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IFN-γ-inducible protein 16 (IFI16) is an immunological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway. Because mice do not have a clear ortholog of IFI16, this system is not suitable for genetic studies of IFI16. In this study, we have compared the dependency on IFI16, cyclic GMP-AMP synthase, and stimulator of IFN genes for type I IFN induction by a panel of pathogenic bacteria and DNA viruses. The IFN response induced by HSV-2 was particularly dependent on IFI16. In a cohort of patients with genital herpes and healthy controls, the minor G allele of the single nucleotide polymorphism rs2276404 was associated with resistance to infection. Furthermore, the combination of this allele with the C allele of rs1417806 was significantly overrepresented in uninfected individuals. Cells from individuals with the protective GC haplotype expressed higher levels of IFI16 and induced more IFN-ß upon HSV-2 infection. These data provide genetic evidence for a role for IFI16 in protection against genital herpes.
[Mh] Termos MeSH primário: Genótipo
Herpes Genital/imunologia
Herpesvirus Humano 2/imunologia
Interferon beta/metabolismo
Proteínas Nucleares/genética
Fosfoproteínas/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Linhagem Celular
Estudos de Coortes
DNA Viral/imunologia
Frequência do Gene
Estudos de Associação Genética
Seres Humanos
Masculino
Camundongos
Meia-Idade
Proteínas Nucleares/metabolismo
Fosfoproteínas/metabolismo
Polimorfismo de Nucleotídeo Único
Regulação para Cima
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 0 (Nuclear Proteins); 0 (Phosphoproteins); 148998-64-5 (IFI16 protein, human); 77238-31-4 (Interferon-beta)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700385


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[PMID]:28854795
[Au] Autor:Michútová M; Mrázová V; Kúdelová M; Smolinská M; Supoliková M; Vrbová M; Golais F
[Ti] Título:Herpes simplex viruses type 1 and 2 photoinactivated in the presence of methylene blue transform human and mouse cells in vitro.
[So] Source:Acta Virol;61(3):308-315, 2017.
[Is] ISSN:0001-723X
[Cp] País de publicação:Slovakia
[La] Idioma:eng
[Ab] Resumo:Three strains of herpes simplex virus, K17syn- and HSZPsyn+ of type 1 (HSV-1) and USsyn- of type 2 (HSV-2), were photoinactivated in the presence of methylene blue and used to infect 3 cell lines, normal human lung tissue cells (MRC-5), mouse epithelial cells (NIH3T3), and human lung carcinoma cells (A549). The virus titer and phenotype of cells were evaluated to compare the characteristics of normal and carcinoma cells infected with non-syncytial (non-syn) and syncytial (syn) strains of herpes simplex viruses. We found that the cells of both normal cell lines infected with photoinactivated K17syn- and USsyn- but not HSZPsyn+ acquired transformed phenotype accompanied by the presence of virus. Surprisingly, the infection with photoinactivated viruses K17syn- and USsyn- but not HSZPsyn+ resulted in the suppression of the transformed phenotype of A549 cells. Using nested PCR, herpesviral DNA was identified in newly transformed cells and cells that lost the transformed phenotype. The effect of putative herpesvirus-related growth factors (HRGF) produced by cells infected with photoinactivated viruses was quantified and compared. Since methylene blue is currently used in phototherapy of herpetic lesions, these results raise the question of whether such therapy is risky to human health.
[Mh] Termos MeSH primário: Herpes Simples/virologia
Herpesvirus Humano 1/efeitos dos fármacos
Herpesvirus Humano 1/metabolismo
Herpesvirus Humano 2/efeitos dos fármacos
Herpesvirus Humano 2/metabolismo
Azul de Metileno/administração & dosagem
[Mh] Termos MeSH secundário: Células A549
Animais
Linhagem Celular
Linhagem Celular Tumoral
Seres Humanos
Masculino
Camundongos
Meia-Idade
Células NIH 3T3
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
T42P99266K (Methylene Blue)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.4149/av_2017_309



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