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  1 / 247 MEDLINE  
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[PMID]:28235707
[Au] Autor:Camero M; Buonavoglia D; Lucente MS; Losurdo M; Crescenzo G; Trerotoli P; Casalino E; Martella V; Elia G; Tempesta M
[Ad] Endereço:Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.
[Ti] Título:Enhancement of the antiviral activity against caprine herpesvirus type 1 of Acyclovir in association with Mizoribine.
[So] Source:Res Vet Sci;111:120-123, 2017 Apr.
[Is] ISSN:1532-2661
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Caprine herpesvirus 1 (CpHV-1) infection in goats is responsible for genital lesions resembling the lesions induced by herpesvirus 2 in humans (HHV-2). The immunosuppressive drug Mizoribine (MIZ) is able to increase the antiviral activity of Acyclovir (ACV) against herpesvirus infections, raising interesting perspectives on new combined therapeutic strategies. In this study the anti-CpHV-1 activity in vitro of ACV alone or in combination with MIZ was evaluated. ACV (100µg/ml) displayed an antiviral effect on CpHV-1 replication. This inhibitory effect was higher when ACV (100µg/ml) was used in association with MIZ (20µg/ml). Other combinations of ACV and MIZ in various concentrations were not as effective as ACV 100µg/ml/MIZ 20µg/ml. These findings suggest that the association of ACV and MIZ is potentially useful for treatment of genital infection by herpesviruses.
[Mh] Termos MeSH primário: Aciclovir/farmacologia
Antivirais/farmacologia
Doenças das Cabras/tratamento farmacológico
Infecções por Herpesviridae/veterinária
Imunossupressores/farmacologia
Ribonucleosídeos/farmacologia
Varicellovirus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Bovinos
Linhagem Celular
Doenças das Cabras/virologia
Cabras
Infecções por Herpesviridae/tratamento farmacológico
Infecções por Herpesviridae/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Immunosuppressive Agents); 0 (Ribonucleosides); 4JR41A10VP (mizoribine); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE


  2 / 247 MEDLINE  
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Roehe, Paulo Michel
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[PMID]:28063080
[Au] Autor:Scheffer CM; Varela AP; Cibulski SP; Schmidt C; Campos FS; Paim WP; Dos Santos RN; Teixeira TF; Loiko MR; Tochetto C; Dos Santos HF; de Lima DA; Cerva C; Mayer FQ; Petzhold SA; Franco AC; George TS; Spilki FR; Roehe PM
[Ad] Endereço:Institute of Veterinary Research "Desidério Finamor" (IPVDF), Estrada do Conde 6000, Eldorado do Sul, Rio Grande do Sul, CEP 92990-000, Brazil. scheffer.cm@gmail.com.
[Ti] Título:Genome sequence of bubaline alphaherpesvirus 1 (BuHV1) isolated in Australia in 1972.
[So] Source:Arch Virol;162(5):1169-1176, 2017 May.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Bubaline alphaherpesvirus 1 (BuHV1) is a member of the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus. To date, no full genome sequence of BuHV has been published. Here, we report the complete genome sequence of bubaline alphaherpesvirus 1 (BuHV1) strain b6 (BuHV1-b6), isolated from a water buffalo (Bubalus bubalis) in 1972 in Australia. The virus was multiplied in MDBK cells, and the DNA was extracted and subjected to high-throughput sequencing. The reads were aligned and combined into a single genome sequence, with bovine alphaherpesvirus 5 (BoHV5) strain SV507/99 (accession number NC005261) as a reference. The BuHV1-b6 genome is a linear double-stranded DNA molecule, 137,452 bp long, with a GC content of 76.8%. The genome consists of two unique sequences: a long, or UL, sequence (103,818 bp) and a short, or US, sequence (9,586 bp), with the latter being flanked by inverted IR and TR elements of 12,024 bp each. The arrangement is typical of herpesvirus genomes of the D-type. The overall sequence has a 92.2% similarity at the nucleotide level to the reference BoHV5 strain. Our report provides a significant landmark in the history of herpesviruses, represented by the genome sequence of this 44-year-old virus isolate.
[Mh] Termos MeSH primário: Búfalos/virologia
DNA Viral/genética
Genoma Viral/genética
Varicellovirus/genética
[Mh] Termos MeSH secundário: Animais
Austrália
Sequência de Bases
Bovinos
Linhagem Celular
Cães
Sequenciamento de Nucleotídeos em Larga Escala
Células Madin Darby de Rim Canino
Análise de Sequência de DNA
Varicellovirus/classificação
Varicellovirus/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-016-3218-8


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[PMID]:26639080
[Au] Autor:Pusterla N; Magdesian KG; Mapes SM; Zavodovskaya R; Kass PH
[Ad] Endereço:Department of Medicine and Epidemiology, University of California, Davis, USA.
[Ti] Título:Assessment of quantitative polymerase chain reaction for equine herpesvirus-5 in blood, nasal secretions and bronchoalveolar lavage fluid for the laboratory diagnosis of equine multinodular pulmonary fibrosis.
[So] Source:Equine Vet J;49(1):34-38, 2017 Jan.
[Is] ISSN:2042-3306
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:REASONS FOR PERFORMING STUDY: The ante mortem diagnosis of equine multinodular pulmonary fibrosis (EMPF) relies on histopathological results and polymerase chain reaction (PCR)-positive equine herpesvirus (EHV)-5 testing of lung tissue. Polymerase chain reaction detection of EHV-5 in bronchoalveolar lavage fluid (BALF) is commonly used to support a diagnosis of EMPF. However, the diagnostic power of EHV-5 testing on BALF and other biological samples such as blood and nasal secretions has yet to be shown to support a diagnosis of EMPF. OBJECTIVES: To determine the frequency of detection and the viral loads of EHV-5 by quantitative PCR (qPCR) in blood, nasal secretions and BALF from horses confirmed with EMPF, healthy horses and horses with non-EMPF pulmonary diseases. STUDY DESIGN: Prospective study. METHODS: The study population consisted of 70 adult horses divided into 4 groups based on a combination of clinical findings, cytology of BALF, imaging studies of the thoracic cavity and histopathology of pulmonary tissue: control group (n = 14), EMPF group (n = 11); inflammatory airway disease group (n = 32); and non-EMPF interstitial lung disease group (n = 13). For each horse, whole blood, nasal secretions and BALF were available for EHV-5 qPCR testing. Sensitivities, specificities and their respective 95% confidence intervals were calculated for viral loads from blood, nasal secretions and BALF. In addition, these measures were calculated for combined use of blood and nasal secretions. RESULTS: The detection of EHV-5 in BALF was strongly associated with EMPF (sensitivity 91%, specificity 98.3%). Detection of EHV-5 in blood was, independent of the viral loads, strongly associated with EMPF with a sensitivity of 91% and specificity of 83.1%. The detection of EHV-5 in nasal secretions displayed the highest sensitivity (72.7%) and specificity (83.1%) at a level of >245,890 glycoprotein B target genes/million cells to support a diagnosis of EMPF. Dually positive blood and nasal secretions at any viral loads in support of EMPF yielded a sensitivity and specificity of 90% and 89.8%, respectively. CONCLUSIONS: Although histopathological confirmation (lung biopsy) is considered the gold standard for EMPF diagnosis, results of qPCR testing of BALF or a combination of whole blood and nasal secretions should be regarded as clinically useful in support of this diagnosis. The latter testing may be relevant when dealing with horses in respiratory distress, for which invasive procedures such as BALF collection or lung biopsies may be detrimental to their health.
[Mh] Termos MeSH primário: Líquido da Lavagem Broncoalveolar/virologia
Infecções por Herpesviridae/veterinária
Doenças dos Cavalos/virologia
Reação em Cadeia da Polimerase/veterinária
Fibrose Pulmonar/veterinária
Varicellovirus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Infecções por Herpesviridae/diagnóstico
Infecções por Herpesviridae/virologia
Doenças dos Cavalos/sangue
Doenças dos Cavalos/diagnóstico
Cavalos
Muco/virologia
Fibrose Pulmonar/sangue
Fibrose Pulmonar/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170315
[Lr] Data última revisão:
170315
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151208
[St] Status:MEDLINE
[do] DOI:10.1111/evj.12545


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[PMID]:27681124
[Au] Autor:Arnold N; Girke T; Sureshchandra S; Messaoudi I
[Ad] Endereço:Graduate Program in Microbiology, University of California-Riverside, Riverside, California, USA.
[Ti] Título:Acute Simian Varicella Virus Infection Causes Robust and Sustained Changes in Gene Expression in the Sensory Ganglia.
[So] Source:J Virol;90(23):10823-10843, 2016 Dec 01.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Primary infection with varicella-zoster virus (VZV), a neurotropic alphaherpesvirus, results in varicella. VZV establishes latency in the sensory ganglia and can reactivate later in life to cause herpes zoster. The relationship between VZV and its host during acute infection in the sensory ganglia is not well understood due to limited access to clinical specimens. Intrabronchial inoculation of rhesus macaques with simian varicella virus (SVV) recapitulates the hallmarks of VZV infection in humans. We leveraged this animal model to characterize the host-pathogen interactions in the ganglia during both acute and latent infection by measuring both viral and host transcriptomes on days postinfection (dpi) 3, 7, 10, 14, and 100. SVV DNA and transcripts were detected in sensory ganglia 3 dpi, before the appearance of rash. CD4 and CD8 T cells were also detected in the sensory ganglia 3 dpi. Moreover, lung-resident T cells isolated from the same animals 3 dpi also harbored SVV DNA and transcripts, suggesting that T cells may be responsible for trafficking SVV to the ganglia. Transcriptome sequencing (RNA-Seq) analysis showed that cessation of viral transcription 7 dpi coincides with a robust antiviral innate immune response in the ganglia. Interestingly, a significant number of genes that play a critical role in nervous system development and function remained downregulated into latency. These studies provide novel insights into host-pathogen interactions in the sensory ganglia during acute varicella and demonstrate that SVV infection results in profound and sustained changes in neuronal gene expression. IMPORTANCE: Many aspects of VZV infection of sensory ganglia remain poorly understood, due to limited access to human specimens and the fact that VZV is strictly a human virus. Infection of rhesus macaques with simian varicella virus (SVV), a homolog of VZV, provides a robust model of the human disease. Using this model, we show that SVV reaches the ganglia early after infection, most likely by T cells, and that the induction of a robust innate immune response correlates with cessation of virus transcription. We also report significant changes in the expression of genes that play an important role in neuronal function. Importantly, these changes persist long after viral replication ceases. Given the homology between SVV and VZV, and the genetic and physiological similarities between rhesus macaques and humans, our results provide novel insight into the interactions between VZV and its human host and explain some of the neurological consequences of VZV infection.
[Mh] Termos MeSH primário: Gânglios Sensitivos/metabolismo
Gânglios Sensitivos/virologia
Infecções por Herpesviridae/genética
Infecções por Herpesviridae/virologia
Varicellovirus/patogenicidade
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Transporte Axonal
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Varicela/virologia
DNA Viral/genética
DNA Viral/metabolismo
Modelos Animais de Doenças
Gânglios Sensitivos/imunologia
Expressão Gênica
Infecções por Herpesviridae/imunologia
Herpesvirus Humano 3/patogenicidade
Interações Hospedeiro-Patógeno/genética
Interações Hospedeiro-Patógeno/imunologia
Seres Humanos
Macaca mulatta
Neurogênese
Varicellovirus/genética
Varicellovirus/fisiologia
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE


  5 / 247 MEDLINE  
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[PMID]:27296722
[Au] Autor:Godoy MG; Kibenge MJ; Wang Y; Suarez R; Leiva C; Vallejos F; Kibenge FS
[Ad] Endereço:Centro de Investigaciones Biológicas Aplicadas (CIBA), Diego de Almagro Norte 1013, No. 8, Puerto Montt, Chile.
[Ti] Título:First description of clinical presentation of piscine orthoreovirus (PRV) infections in salmonid aquaculture in Chile and identification of a second genotype (Genotype II) of PRV.
[So] Source:Virol J;13:98, 2016 Jun 13.
[Is] ISSN:1743-422X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Heart and skeletal muscle inflammation (HSMI) is an emerging disease of marine-farmed Atlantic salmon Salmo salar, first recognized in 1999 in Norway, and recently associated with piscine orthoreovirus (PRV) infection. To date, HSMI lesions with presence of PRV have only been described in marine-farmed Atlantic salmon in Norway. A new HSMI-like disease in rainbow trout Oncorhynchus mykiss associated with a PRV-related virus has also been reported in Norway. METHODS: Sampling of Atlantic salmon and coho salmon was done during potential disease outbreaks, targeting lethargic/moribund fish. Fish were necropsied and tissues were taken for histopathologic analysis and testing for PRV by RT-qPCR assay for segment L1 and conventional RT-PCR for PRV segment S1. The PCR products were sequenced and their relationship to PRV strains in GenBank was determined using phylogenetic analysis and nucleotide and amino acid homology comparisons. RESULTS: The Atlantic salmon manifested the classical presentation of HSMI with high PRV virus loads (low Ct values) as described in Norway. The coho salmon with low Ct values had myocarditis but only in the spongy layer, the myositis of red muscle in general was mild, and the hepatic necrosis was severe. Upon phylogenetic analysis of PRV segment S1 sequences, all the Chilean PRV strains from Atlantic salmon grouped as sub-genotype Ib, whereas the Chilean PRV strains from coho salmon were more diversified, grouping in both sub-genotypes Ia and Ib and others forming a distinct new phylogenetic cluster, designated Genotype II that included the Norwegian PRV-related virus. CONCLUSIONS: To our knowledge the present work constitutes the first published report of HSMI lesions with presence of PRV in farmed Atlantic salmon outside of Europe, and the first report of HSMI-like lesions with presence of PRV in coho salmon in Chile. The Chilean PRV strains from coho salmon are more genetically diversified than those from Atlantic salmon, and some form a distinct new phylogenetic cluster, designated Genotype II.
[Mh] Termos MeSH primário: Doenças dos Peixes/virologia
Genótipo
Orthoreovirus/classificação
Orthoreovirus/isolamento & purificação
Infecções por Reoviridae/veterinária
[Mh] Termos MeSH secundário: Animais
Aquicultura
Basidiomycota
Chile
Análise por Conglomerados
Doenças dos Peixes/patologia
Histocitoquímica
Oncorhynchus kisutch
Oncorhynchus mykiss
Orthoreovirus/genética
Filogenia
Reação em Cadeia da Polimerase em Tempo Real
Infecções por Reoviridae/patologia
Salmo salar
Análise de Sequência de DNA
Varicellovirus
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE
[do] DOI:10.1186/s12985-016-0554-y


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[PMID]:27091747
[Au] Autor:Thomasy SM; Maggs DJ
[Ad] Endereço:Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
[Ti] Título:A review of antiviral drugs and other compounds with activity against feline herpesvirus type 1.
[So] Source:Vet Ophthalmol;19 Suppl 1:119-30, 2016 Jul.
[Is] ISSN:1463-5224
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Feline herpesvirus type 1 (FHV-1) is a common and important cause of ocular surface disease, dermatitis, respiratory disease, and potentially intraocular disease in cats. Many antiviral drugs developed for the treatment of humans infected with herpesviruses have been used to treat cats infected with FHV-1. Translational use of drugs in this manner ideally requires methodical investigation of their in vitro efficacy against FHV-1 followed by pharmacokinetic and safety trials in normal cats. Subsequently, placebo-controlled efficacy studies in experimentally inoculated animals should be performed followed, finally, by carefully designed and monitored clinical trials in client-owned animals. This review is intended to provide a concise overview of the available literature regarding the efficacy of antiviral drugs and other compounds with proven or putative activity against FHV-1, as well as a discussion of their safety in cats.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Varicellovirus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Doenças do Gato/tratamento farmacológico
Doenças do Gato/virologia
Gatos
Infecções por Herpesviridae/tratamento farmacológico
Infecções por Herpesviridae/veterinária
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160420
[St] Status:MEDLINE
[do] DOI:10.1111/vop.12375


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[PMID]:26959283
[Au] Autor:Pennington MR; Fort MW; Ledbetter EC; Van de Walle GR
[Ad] Endereço:1​ Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, United States.
[Ti] Título:A novel corneal explant model system to evaluate antiviral drugs against feline herpesvirus type 1 (FHV-1).
[So] Source:J Gen Virol;97(6):1414-25, 2016 Jun.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Feline herpesvirus type-1 (FHV-1) is the most common viral cause of ocular surface disease in cats. Many antiviral drugs are used to treat FHV-1, but require frequent topical application and most lack well-controlled in vivo studies to justify their clinical use. Therefore, better validation of current and novel treatment options are urgently needed. Here, we report on the development of a feline whole corneal explant model that supports FHV-1 replication and thus can be used as a novel model system to evaluate the efficacy of antiviral drugs. The anti-herpes nucleoside analogues cidofovir and acyclovir, which are used clinically to treat ocular herpesvirus infection in cats and have previously been evaluated in traditional two-dimensional feline cell cultures in vitro, were evaluated in this explant model. Both drugs suppressed FHV-1 replication when given every 12 h, with cidofovir showing greater efficacy. In addition, the potential efficacy of the retroviral integrase inhibitor raltegravir against FHV-1 was evaluated in cell culture as well as in the explant model. Raltegravir was not toxic to feline cells or corneas, and most significantly, inhibited FHV-1 replication at 500 µM in both systems. Importantly, this drug was effective when given only once every 24 h. Taken together, our data indicate that the feline whole corneal explant model is a useful tool for the evaluation of antiviral drugs and, furthermore, that raltegravir appears a promising novel antiviral drug to treat ocular herpesvirus infection in cats.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Córnea/virologia
Avaliação Pré-Clínica de Medicamentos/métodos
Técnicas de Cultura de Órgãos/métodos
Varicellovirus/efeitos dos fármacos
Cultura de Vírus/métodos
[Mh] Termos MeSH secundário: Aciclovir/farmacologia
Animais
Gatos
Citosina/análogos & derivados
Citosina/farmacologia
Organofosfonatos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Organophosphonates); 8J337D1HZY (Cytosine); JIL713Q00N (cidofovir); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160310
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000451


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[PMID]:26795546
[Au] Autor:Nelli RK; Maes R; Kiupel M; Hussey GS
[Ad] Endereço:Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, 784 Wilson Road, East Lansing, MI 48824, USA. Electronic address: rknelli@msu.edu.
[Ti] Título:Use of a feline respiratory epithelial cell culture system grown at the air-liquid interface to characterize the innate immune response following feline herpesvirus 1 infection.
[So] Source:Virus Res;214:39-48, 2016 Mar 02.
[Is] ISSN:1872-7492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Infection with feline herpesvirus-1 (FHV-1) accounts for 50% of viral upper respiratory diseases in domestic cats and is a significant cause of ocular diseases. Despite the clinical significance and high prevalence of FHV-1 infection, currently available vaccines cannot completely protect cats from infection and lifelong latency. FHV-1 infects via the mucous membranes and replicates in respiratory epithelial cells, but very little is known about the early innate immunity at this site. To address questions about immunity to FHV-1, feline respiratory epithelial cells cultured at air-liquid interface (ALI-FRECs) were established by collecting respiratory tracts from 6 healthy cats after euthanasia. Cells were isolated, cultured and characterized histologically and immunologically before infection with FHV-1. The expression of Toll-like receptors (TLRs), cytokine and chemokine responses were measured by real time PCR. ALI-FRECs morphologically resembled the natural airways of cats with multilayered columnar epithelial cells and cilia. Immunological properties of the natural airways were maintained in ALI-FRECs, as evidenced by the expression of TLRs, cytokines, chemokines, interferons, beta-defensins, and other regulatory genes. Furthermore, ALI-FRECs were able to support infection and replication of FHV-1, as well as modulate transcriptional regulation of various immune genes in response to infection. IL-1ß and TNFα were increased in ALI-FRECs by 24hpi, whereas expression levels of IFN-α and TLR9 were not increased until 36hpi. In contrast, TLR3, GM-CSF and TGF-1ß expression was down-regulated at 36hpi. The data presented show the development of a system ideal for investigating the molecular pathogenesis and immunity of FHV-1 or other respiratory pathogens.
[Mh] Termos MeSH primário: Doenças do Gato/imunologia
Doenças do Gato/virologia
Imunidade Inata
Varicellovirus/fisiologia
[Mh] Termos MeSH secundário: Animais
Doenças do Gato/metabolismo
Gatos
Linhagem Celular
Células Cultivadas
Quimiocinas/genética
Quimiocinas/metabolismo
Citocinas/genética
Citocinas/metabolismo
Células Epiteliais
Expressão Gênica
Imunidade Inata/genética
Mediadores da Inflamação/metabolismo
Receptores de Reconhecimento de Padrão/genética
Receptores de Reconhecimento de Padrão/metabolismo
Receptores Toll-Like/genética
Receptores Toll-Like/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chemokines); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Receptors, Pattern Recognition); 0 (Toll-Like Receptors)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160123
[St] Status:MEDLINE


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[PMID]:25835328
[Au] Autor:Camero M; Marinaro M; Losurdo M; Larocca V; Bodnar L; Patruno G; Buonavoglia C; Tempesta M
[Ad] Endereço:a Department of Veterinary Medicine , University of Bari , Sp. Casamassima km 3, 70010 Valenzano , BA , Italy.
[Ti] Título:Caprine herpesvirus 1 (CpHV-1) vaginal infection of goats: clinical efficacy of fig latex.
[So] Source:Nat Prod Res;30(5):605-7, 2016.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The latex of Ficus carica Linn. (Moraceae) has been shown to interfere with the replication of caprine herpesvirus (CpHV)-1 in vitro. The present study was undertaken to determine the efficacy of vaginal administration of fig latex in goats experimentally infected with CpHV-1. The fig latex reduced the clinical signs of the herpetic disease although it slightly influenced the titres of CpHV-1 shed. Thus, the fig latex maintained a partial efficacy in vivo.
[Mh] Termos MeSH primário: Ficus/química
Doenças das Cabras/tratamento farmacológico
Cabras
Infecções por Herpesviridae/tratamento farmacológico
Látex/uso terapêutico
Doenças Vaginais/tratamento farmacológico
Doenças Vaginais/veterinária
Varicellovirus
[Mh] Termos MeSH secundário: Animais
Feminino
Doenças das Cabras/virologia
Infecções por Herpesviridae/virologia
Resultado do Tratamento
Doenças Vaginais/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Latex)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160118
[Lr] Data última revisão:
160118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150404
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1028061


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[PMID]:26259874
[Au] Autor:Ogunjimi B; Willem L; Beutels P; Hens N
[Ad] Endereço:Centre for Health Economics Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
[Ti] Título:Integrating between-host transmission and within-host immunity to analyze the impact of varicella vaccination on zoster.
[So] Source:Elife;4, 2015 Jul 11.
[Is] ISSN:2050-084X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Varicella-zoster virus (VZV) causes chickenpox and reactivation of latent VZV causes herpes zoster (HZ). VZV reactivation is subject to the opposing mechanisms of declining and boosted VZV-specific cellular mediated immunity (CMI). A reduction in exogenous re-exposure 'opportunities' through universal chickenpox vaccination could therefore lead to an increase in HZ incidence. We present the first individual-based model that integrates within-host data on VZV-CMI and between-host transmission data to simulate HZ incidence. This model allows estimating currently unknown pivotal biomedical parameters, including the duration of exogenous boosting at 2 years, with a peak threefold to fourfold increase of VZV-CMI; the VZV weekly reactivation probability at 5% and VZV subclinical reactivation having no effect on VZV-CMI. A 100% effective chickenpox vaccine given to 1 year olds would cause a 1.75 times peak increase in HZ 31 years after implementation. This increase is predicted to occur mainly in younger age groups than is currently assumed.
[Mh] Termos MeSH primário: Vacina contra Varicela/administração & dosagem
Vacina contra Varicela/imunologia
Herpes Zoster/epidemiologia
Herpes Zoster/imunologia
Imunidade Celular
Varicellovirus/imunologia
Ativação Viral
[Mh] Termos MeSH secundário: Seres Humanos
Modelos Biológicos
Modelos Estatísticos
Medição de Risco
Varicellovirus/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chickenpox Vaccine)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150812
[St] Status:MEDLINE
[do] DOI:10.7554/eLife.07116



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