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  1 / 115 MEDLINE  
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[PMID]:27938671
[Au] Autor:Ledbetter EC; Kim K; Dubovi EJ; Mohammed HO; Felippe MJ
[Ad] Endereço:Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. Electronic address: ecl32@cornell.edu.
[Ti] Título:Clinical and immunological assessment of therapeutic immunization with a subunit vaccine for recurrent ocular canine herpesvirus-1 infection in dogs.
[So] Source:Vet Microbiol;197:102-110, 2016 Dec 25.
[Is] ISSN:1873-2542
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Latent canine herpesvirus-1 (CHV-1) infections are common in domestic dogs and reactivation of latent virus may be associated with recurrent ocular disease. The objectives of the present study were to evaluate the ability of a subunit CHV-1 vaccine to stimulate peripheral CHV-1 specific immunity and prevent recurrent CHV-1 ocular disease and viral shedding. Mature dogs with experimentally-induced latent CHV-1 infection received a 2-dose CHV-1 vaccine series. Recurrent ocular CHV-1 infection was induced by corticosteroid administration in the prevaccinal, short-term postvaccinal (2 weeks post-vaccination), and long-term postvacccinal (34 weeks post-vaccination) periods. Immunological, virological, and clinical parameters were evaluated during each study period. Quantitative assessment of peripheral immunity included lymphocyte immunophenotyping, proliferation response, and interferon-γ production; and CHV-1 virus neutralizing antibody production. In the present study, vaccination did not prevent development of ocular disease and viral shedding; however, there was a significant decrease in clinical ocular disease scores in the short-term postvaccinal period. Significant alterations in peripheral immunity detected in the dogs during the short-term and long-term postvaccinal periods included increased T and B lymphocyte subpopulation percentage distributions, increased lymphocyte expression of major histocompatibility complex class I and II, increased CHV-1 virus neutralizing antibody titers, decreased lymphocyte proliferation, and decreased interferon-γ production. Vaccination of latently infected mature dogs with the selected subunit CHV-1 vaccine was not effective in preventing recurrent ocular CHV-1 infection and viral shedding induced by corticosteroid administration. The vaccine did induce long-term CHV-1 specific immunity and may decrease the severity of clinical ocular disease in the immediate postvaccinal period.
[Mh] Termos MeSH primário: Doenças do Cão/terapia
Infecções Oculares Virais/veterinária
Infecções por Herpesviridae/veterinária
Herpesvirus Canídeo 1/imunologia
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Animais
Citocinas
Cães
Infecções Oculares Virais/prevenção & controle
Feminino
Infecções por Herpesviridae/terapia
Infecções por Herpesviridae/virologia
Masculino
Prednisolona
Recidiva
Vacinas Sintéticas
Latência Viral
Eliminação de Partículas Virais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Vaccines, Synthetic); 0 (Viral Vaccines); 9PHQ9Y1OLM (Prednisolone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  2 / 115 MEDLINE  
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[PMID]:27668586
[Au] Autor:Spertus CB; Mohammed HO; Ledbetter EC
[Ti] Título:Effects of topical ocular application of 1% trifluridine ophthalmic solution in dogs with experimentally induced recurrent ocular canine herpesvirus-1 infection.
[So] Source:Am J Vet Res;77(10):1140-7, 2016 Oct.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To determine the effects of topical ocular application of 1% trifluridine ophthalmic solution in dogs with experimentally induced recurrent ocular canine herpesvirus-1 (CHV-1) infection. ANIMALS 10 specific pathogen-free Beagles. PROCEDURES 12 months prior to the beginning of the randomized, masked, placebo-controlled 30-day trial, latent ocular CHV-1 infection was experimentally induced in each dog by topical ocular inoculation of both eyes with a field strain of CHV-1. Recurrent ocular CHV-1 infection was induced by oral administration of prednisolone for 7 days (starting day 1). Starting on the fourth day of prednisolone administration, each dog received 1% trifluridine solution or artificial tears (placebo) topically in both eyes 6 times daily for 2 days and then 4 times daily for 12 days. Ophthalmic examinations were performed every 2 days, and ocular disease scores were calculated. Ocular samples for CHV-1 PCR assays and blood samples for clinicopathologic analyses and assessment of CHV-1 serum neutralization antibody titers were collected at predetermined intervals. RESULTS Conjunctivitis was clinically detected in all dogs by day 4. Compared with dogs receiving placebo, mean and total clinical ocular disease scores were significantly lower and median CHV-1 shedding duration was significantly shorter for the trifluridine-treated dogs. Both groups had increasing CHV-1 serum neutralization antibody titers over time, but no significant differences between groups were detected. Clinicopathologic findings were unremarkable throughout the study. CONCLUSIONS AND CLINICAL RELEVANCE Topical ocular application of 1% trifluridine ophthalmic solution was well tolerated and effective at reducing disease scores and viral shedding duration in dogs with experimentally induced ocular CHV-1 infection, but may require frequent administration.
[Mh] Termos MeSH primário: Antivirais/uso terapêutico
Doenças do Cão/tratamento farmacológico
Infecções Oculares Virais/veterinária
Infecções por Herpesviridae/veterinária
Herpesvirus Canídeo 1
Soluções Oftálmicas/uso terapêutico
Trifluridina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Cães
Infecções Oculares Virais/tratamento farmacológico
Feminino
Infecções por Herpesviridae/tratamento farmacológico
Masculino
Reação em Cadeia da Polimerase/veterinária
Eliminação de Partículas Virais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Ophthalmic Solutions); RMW9V5RW38 (Trifluridine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE
[do] DOI:10.2460/ajvr.77.10.1140


  3 / 115 MEDLINE  
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[PMID]:27033934
[Au] Autor:Li Y; Negussie H; Qiu Y; Reddy VR; Mateusen B; Nauwynck HJ
[Ad] Endereço:Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium.
[Ti] Título:Early events of canine herpesvirus 1 infections in canine respiratory and genital mucosae by the use of ex vivo models.
[So] Source:Res Vet Sci;105:205-8, 2016 Apr.
[Is] ISSN:1532-2661
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Canine herpesvirus 1 (CaHV-1) causes a systemic disease in newborn puppies, kennel cough at all ages and genital lesions in adult dogs. The aim of the present study was to elucidate the viral behavior during the early stage of infection in respiratory and genital mucosae, the portals of entry for CaHV-1 by the use of ex vivo explants. CaHV-1 infected and replicated in respiratory and vaginal mucosae in a plaque wise manner. CaHV-1 started to penetrate the basement membrane (BM) only after 48 h post inoculation (hpi) in respiratory mucosal explants, but already after 24 hpi in vaginal explants. The plaque latitude and penetration depth increased over time and both were larger in the vaginal explants compared to the respiratory mucosal explants. The canine respiratory and genital mucosal explants were suitable to study the early pathogenesis of CaHV-1. CaHV-1 showed a better capacity to replicate and invade vaginal mucosa compared to respiratory mucosa, based on the latitude and penetration depth of the plaques of viral antigen positive cells.
[Mh] Termos MeSH primário: Doenças do Cão/virologia
Infecções por Herpesviridae/veterinária
Herpesvirus Canídeo 1/fisiologia
[Mh] Termos MeSH secundário: Animais
Cães
Feminino
Genitália Feminina/virologia
Infecções por Herpesviridae/virologia
Membrana Mucosa/virologia
Mucosa Respiratória/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE


  4 / 115 MEDLINE  
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[PMID]:26726105
[Au] Autor:Bottinelli M; Rampacci E; Stefanetti V; Marenzoni ML; Malmlov AM; Coletti M; Passamonti F
[Ad] Endereço:Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia (PG), Italy.
[Ti] Título:Serological and biomolecular survey on canine herpesvirus-1 infection in a dog breeding kennel.
[So] Source:J Vet Med Sci;78(5):797-802, 2016 Jun 01.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Canine herpesvirus-1 (CaHV-1) is a globally distributed pathogen causing reproductive, respiratory, ocular and neurological disorders in adult dogs and neonatal death in puppies. This pathogen is considered poorly immunogenic, and neutralizing antibodies are found for only a short time following exposure. Further, seroprevalence can be affected by several epidemiological factors. A virological survey was conducted in a high-density population breeding kennel in Central Italy. There were several factors predisposing animals to CaHV-1 infection, such as age, number of pregnancies, experience with mating and dog shows, cases of abortion, management and environmental hygiene. Serum neutralization (SN) and nested PCR assays were used to estimate prevalence of CaHV-1. None of the submitted samples tested positive for nested PCR, and none of the sera tested CaHV-1 positive. No association was observed between antibody titers and risk factors, and no sign of viral reactivation was detected in either males or females. These results suggest that CaHV-1 is not circulating within this kennel and that further studies are needed in order to better understand the distribution of the virus within Italy.
[Mh] Termos MeSH primário: Doenças do Cão/virologia
Infecções por Herpesviridae/veterinária
Herpesvirus Canídeo 1
[Mh] Termos MeSH secundário: Animais
Doenças do Cão/epidemiologia
Cães
Feminino
Infecções por Herpesviridae/epidemiologia
Itália/epidemiologia
Masculino
Reação em Cadeia da Polimerase/veterinária
Prevalência
Fatores de Risco
Testes Sorológicos/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160105
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.15-0543


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[PMID]:26589403
[Au] Autor:Millán J; López-Bao JV; García EJ; Oleaga Á; Llaneza L; Palacios V; de la Torre A; Rodríguez A; Dubovi EJ; Esperón F
[Ad] Endereço:Facultad de Ecología y Recursos Naturales, Universidad Andres Bello, República 252, Santiago, Chile. syngamustrachea@hotmail.com.
[Ti] Título:Patterns of Exposure of Iberian Wolves (Canis lupus) to Canine Viruses in Human-Dominated Landscapes.
[So] Source:Ecohealth;13(1):123-34, 2016 Mar.
[Is] ISSN:1612-9210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Wildlife inhabiting human-dominated landscapes is at risk of pathogen spill-over from domestic species. With the aim of gaining knowledge in the dynamics of viral infections in Iberian wolves (Canis lupus) living in anthropized landscapes of northern Spain, we analysed between 2010 and 2013 the samples of 54 wolves by serology and polymerase chain reaction (PCR) for exposure to four pathogenic canine viruses: canine distemper virus (CDV), canine parvovirus-2 (CPV), canine adenovirus 1 and 2 (CAV-1 and CAV-2) and canine herpesvirus. Overall, 76% of the studied wolves presented evidence of exposure to CPV (96% by HI, 66% by PCR) and 75% to CAV (75% by virus neutralization (VN), 76% by PCR, of which 70% CAV-1 and 6% CAV-2). This represents the first detection of CAV-2 infection in a wild carnivore. CPV/CAV-1 co-infection occurred in 51% of the wolves. The probability of wolf exposure to CPV was positively and significantly correlated with farm density in a buffer zone around the place where the wolf was found, indicating that rural dogs might be the origin of CPV infecting wolves. CPV and CAV-1 appear to be enzootic in the Iberian wolf population, which is supported by the absence of seasonal and inter-annual variations in the proportion of positive samples detected. However, while CPV may depend on periodical introductions by dogs, CAV-1 may be maintained within the wolf population. All wolves were negative for exposure to CDV (by VN and PCR) and CHV (by PCR). The absence of acquired immunity against CDV in this population may predispose it to an elevated rate of mortality in the event of a distemper spill-over via dogs.
[Mh] Termos MeSH primário: Adenovirus Caninos/isolamento & purificação
Vírus da Cinomose Canina/isolamento & purificação
Herpesvirus Canídeo 1/isolamento & purificação
Parvovirus Canino/isolamento & purificação
Lobos/virologia
[Mh] Termos MeSH secundário: Animais
Animais Selvagens
Coinfecção
Cães/virologia
Seres Humanos
Reação em Cadeia da Polimerase
Fatores de Risco
Testes Sorológicos/veterinária
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151122
[St] Status:MEDLINE
[do] DOI:10.1007/s10393-015-1074-8


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[PMID]:26450840
[Au] Autor:Kapil S
[Ad] Endereço:Oklahoma Animal Disease Diagnostic Laboratory, Center for Veterinary Health Sciences, Stillwater, OK sanjay.kapil@okstate.edu.
[Ti] Título:Canid herpesvirus 1 (CHV-1)-related disease in older puppies and CHV-1 shedding in the vagina of adult pregnant dogs.
[So] Source:J Vet Diagn Invest;27(6):758-61, 2015 Nov.
[Is] ISSN:1943-4936
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A large breeding kennel of Bulldogs (n = 57) experienced several Canid herpesvirus 1 (CHV-1)-related diseases in older puppies (9 weeks of age) in Arkansas. CHV-1 has been repeatedly confirmed in the kennel in several animals for 3 years (January 2012-February 2015) using various virology tests. I was able to detect a partial sequence of CHV DNA (~120 bp) in archived formalin-fixed, paraffin-embedded tissue blocks after 3 years of storage. CHV-1 is persistently circulating in this kennel in spite of high serum antibody titers in the adult dogs. The dogs were negative for canine brucellosis antibodies based on Brucella canis rapid card test.
[Mh] Termos MeSH primário: Doenças do Cão/diagnóstico
Infecções por Herpesviridae/veterinária
Eliminação de Partículas Virais
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Arkansas
DNA Viral/análise
Doenças do Cão/virologia
Cães
Feminino
Infecções por Herpesviridae/diagnóstico
Infecções por Herpesviridae/virologia
Herpesvirus Canídeo 1
Masculino
Gravidez
Especificidade da Espécie
Vagina/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151125
[Lr] Data última revisão:
151125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151010
[St] Status:MEDLINE
[do] DOI:10.1177/1040638715610377


  7 / 115 MEDLINE  
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[PMID]:26418618
[Au] Autor:Ledbetter EC; Spertus CB; Pennington MR; Van de Walle GR; Judd BE; Mohammed HO
[Ad] Endereço:1 Department of Clinical Sciences, Cornell University , Ithaca, New York.
[Ti] Título:In Vitro and In Vivo Evaluation of Cidofovir as a Topical Ophthalmic Antiviral for Ocular Canine Herpesvirus-1 Infections in Dogs.
[So] Source:J Ocul Pharmacol Ther;31(10):642-9, 2015 Dec.
[Is] ISSN:1557-7732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The effects of cidofovir were investigated against canine herpesvirus-1 (CHV-1) in vitro and in dogs with experimentally induced recurrent ocular CHV-1 infection, a host-adapted pathogen animal model of ocular herpes simplex virus-1 (HSV-1) infection. METHODS: The cidofovir EC50 was determined for CHV-1 and HSV-1. A randomized, masked vehicle-controlled trial was performed using beagles with experimentally induced recurrent ocular CHV-1 infection. Dogs received 1 drop of 0.5% cidofovir solution or 0.9% sodium chloride solution (vehicle) in both eyes 2 times daily for 14 days. Dogs were monitored at intervals for 30 days by a clinical ophthalmic examination, in vivo confocal microscopy of the cornea and conjunctiva, ocular sample CHV-1 polymerase chain reaction assay, hemogram, and serum biochemistry panel. Clinical ocular disease scores were calculated and infiltrating leukocytes detected by in vivo confocal microscopy quantified. RESULTS: Cidofovir displayed similar in vitro antiviral activity against CHV-1 and HSV-1. Clinical ocular disease scores were significantly higher in the cidofovir group compared to the vehicle group. Marked conjunctival pigmentation and blepharitis were also detected in the cidofovir group, but not the vehicle group. Conjunctival and corneal leukocyte infiltration scores determined by in vivo confocal microscopy were significantly higher in the cidofovir group. Dogs administered cidofovir had significantly reduced durations of ocular viral shedding compared to the vehicle group. Hemogram and serum biochemistry panel values were unremarkable. CONCLUSIONS: Twice-daily application of topical 0.5% cidofovir ophthalmic solution reduced the duration of ocular viral shedding in dogs with experimentally induced recurrent ocular CHV-1 infection, but was associated with local ocular toxicity.
[Mh] Termos MeSH primário: Citosina/análogos & derivados
Doenças do Cão/virologia
Infecções por Herpesviridae/tratamento farmacológico
Herpesvirus Canídeo 1/efeitos dos fármacos
Organofosfonatos/farmacologia
[Mh] Termos MeSH secundário: Administração Oftálmica
Animais
Antivirais/administração & dosagem
Antivirais/farmacologia
Antivirais/toxicidade
Cercopithecus aethiops
Citosina/administração & dosagem
Citosina/farmacologia
Citosina/toxicidade
Modelos Animais de Doenças
Cães
Infecções por Herpesviridae/virologia
Células Madin Darby de Rim Canino
Microscopia Confocal
Organofosfonatos/administração & dosagem
Organofosfonatos/toxicidade
Distribuição Aleatória
Células Vero
Eliminação de Partículas Virais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Organophosphonates); 8J337D1HZY (Cytosine); JIL713Q00N (cidofovir)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151203
[Lr] Data última revisão:
151203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150930
[St] Status:MEDLINE
[do] DOI:10.1089/jop.2015.0024


  8 / 115 MEDLINE  
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[PMID]:26383748
[Au] Autor:Muro SM; Jugan MC; Ruoff C; Pashmakova MB; Young BD; Scott KD
[Ti] Título:What Is Your Diagnosis? Canine herpesvirus-1 infection.
[So] Source:J Am Vet Med Assoc;247(7):747-9, 2015 Oct 01.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças do Cão/virologia
Infecções por Herpesviridae/veterinária
Herpesvirus Canídeo 1/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Doenças do Cão/patologia
Cães
Evolução Fatal
Infecções por Herpesviridae/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150919
[Lr] Data última revisão:
150919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150919
[St] Status:MEDLINE
[do] DOI:10.2460/javma.247.7.747


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[PMID]:25567292
[Au] Autor:Larsen RW; Kiupel M; Balzer HJ; Agerholm JS
[Ad] Endereço:Section for Veterinary Reproduction and Obstetrics, Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 68, Frederiksberg, DK-1870, Denmark. rikkewendtlarsen@gmail.com.
[Ti] Título:Prevalence of canid herpesvirus-1 infection in stillborn and dead neonatal puppies in Denmark.
[So] Source:Acta Vet Scand;57:1, 2015 Jan 08.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Canid herpesvirus-1 (CaHV-1) infection in puppies less than three weeks of age is often reported to be associated with a lethal generalized necrotizing inflammation and since the discovery of the virus in 1965 several reports of neonatal infections have been published. However, the significance of CaHV-1 for peri- and neonatal mortality in puppies remains unclear. Therefore, we examined stillborn and dead neonatal puppies in Denmark to determine the prevalence of infection and further to correlate infection levels with necropsy findings to assess the possible significance of the infection. RESULTS: From a cross-sectional study of 57 dead puppies, 22.8% (n = 13) were confirmed positive for CaHV-1 by real-time polymerase chain reaction (PCR) of tissue pools of lung/liver and/or spleen/kidney. Specimens from PCR positive cases were further investigated by histology and in situ hybridization (ISH). High levels of CaHV-1 DNA were present in only one case in which lesions and ISH staining consistent with CaHV-1 infection were found as well. CaHV-1 concentrations in the other cases were low and a range of lesions not consistent with CaHV-1 were found. Similar, ISH staining was mostly negative in these except for one case with a few positive cells. CONCLUSION: CaHV-1 infection in stillborn and dead neonatal puppies in Denmark seems to be common, but the direct significance for puppy mortality remains unclear as only one of 13 PCR positive puppies (7.7%) had pathognomonic lesions.
[Mh] Termos MeSH primário: Doenças do Cão/epidemiologia
Infecções por Herpesviridae/veterinária
Herpesvirus Canídeo 1/isolamento & purificação
Natimorto/veterinária
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos/virologia
Estudos Transversais
DNA Viral/análise
Dinamarca/epidemiologia
Doenças do Cão/mortalidade
Doenças do Cão/virologia
Cães
Feminino
Infecções por Herpesviridae/epidemiologia
Infecções por Herpesviridae/mortalidade
Infecções por Herpesviridae/virologia
Masculino
Prevalência
Reação em Cadeia da Polimerase em Tempo Real/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150109
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-014-0092-9


  10 / 115 MEDLINE  
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[PMID]:25358536
[Au] Autor:Kumar S; Driskell EA; Cooley AJ; Jia K; Blackmon S; Wan XF; Uhl EW; Saliki JT; Sanchez S; Krimer PM; Hogan RJ
[Ad] Endereço:Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA.
[Ti] Título:Fatal Canid Herpesvirus 1 Respiratory Infections in 4 Clinically Healthy Adult Dogs.
[So] Source:Vet Pathol;52(4):681-7, 2015 Jul.
[Is] ISSN:1544-2217
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Four healthy adult dogs (Golden Retrievers aged 6 years and 9 years, Dalmatian aged 13 years, and Mastiff aged 5 years) developed clinical signs of acute respiratory disease and died within 2 to 7 days of onset of clinical signs. The lungs of the 3 dogs submitted for necropsy were diffusely and severely reddened due to hyperemia and hemorrhage. Microscopic lesions in all dogs were suggestive of acute viral or toxic respiratory damage and varied from acute severe fibrinonecrotic or hemorrhagic bronchopneumonia to fibrinous or necrotizing bronchointerstitial pneumonia. Necropsied dogs also had hemorrhagic rhinitis and tracheitis with necrosis. Virus isolation, transmission electron microscopy, and polymerase chain reaction were used to confirm the presence of canid herpesvirus 1 (CaHV-1) in the lung samples of these dogs. Lung tissues were negative for influenza A virus, canine distemper virus, canine parainfluenza virus, canine respiratory coronavirus, and canine adenovirus 2. Canid herpesvirus 1 has been isolated from cases of acute infectious respiratory disease in dogs but has only rarely been associated with fatal primary viral pneumonia in adult dogs. The cases in the current report document lesions observed in association with CaHV-1 in 4 cases of fatal canine herpesvirus pneumonia in adult dogs.
[Mh] Termos MeSH primário: Doenças do Cão/patologia
Infecções por Herpesviridae/veterinária
Herpesvirus Canídeo 1/isolamento & purificação
Pneumonia Viral/veterinária
Infecções Respiratórias/veterinária
[Mh] Termos MeSH secundário: Animais
Cães
Evolução Fatal
Feminino
Infecções por Herpesviridae/patologia
Pulmão/patologia
Masculino
Pneumonia Viral/patologia
Reação em Cadeia da Polimerase/veterinária
Infecções Respiratórias/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141101
[St] Status:MEDLINE
[do] DOI:10.1177/0300985814556190



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