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[PMID]:29268134
[Au] Autor:Plebanek E; Lescrinier E; Andrei G; Snoeck R; Herdewijn P; De Jonghe S
[Ad] Endereço:Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Herestraat 49 - bus 1041, 3000 Leuven, Belgium.
[Ti] Título:Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
[So] Source:Eur J Med Chem;144:93-103, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The synthesis of emimycin, 5-substituted emimycin analogues and the corresponding ribo- and 2'-deoxyribonucleoside derivatives is described. Emimycin, its 5-substituted congeners and the ribonucleoside derivatives are completely devoid of antiviral activity against RNA viruses. In contrast, some of the 2'-deoxyribosyl emimycin derivatives are potent inhibitors of the replication of herpes simplex virus-1 and varicella-zoster virus, lacking cytotoxicity.
[Mh] Termos MeSH primário: Antivirais/química
Antivirais/farmacologia
Nucleosídeos/química
Nucleosídeos/farmacologia
Pirazinas/química
Pirazinas/farmacologia
[Mh] Termos MeSH secundário: Antivirais/síntese química
Linhagem Celular
Herpes Simples/tratamento farmacológico
Herpesvirus Humano 1/efeitos dos fármacos
Herpesvirus Humano 1/fisiologia
Herpesvirus Humano 3/efeitos dos fármacos
Herpesvirus Humano 3/fisiologia
Seres Humanos
Nucleosídeos/síntese química
Pirazinas/síntese química
Infecção pelo Vírus da Varicela-Zoster/tratamento farmacológico
Replicação Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Nucleosides); 0 (Pyrazines); R14TE35LHD (emimycin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  2 / 5885 MEDLINE  
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[PMID]:28749818
[Au] Autor:Lehingue S; Rambaud R; Guervilly C; Adda M; Forel JM; Cassir N; Zandotti C; Hraiech S; Papazian L
[Ad] Endereço:Réanimation des Détresses Respiratoires et Infections Sévères, Aix-Marseille University, APHM, Hôpital Nord, Marseille, France.
[Ti] Título:Fatal Septic Shock Triggered by Donor Transmitted Varicella Zoster Virus Reinfection 3 Days After Lung Transplantation.
[So] Source:Transplantation;101(12):e351-e352, 2017 12.
[Is] ISSN:1534-6080
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Herpesvirus Humano 3/patogenicidade
Transplante de Pulmão/efeitos adversos
Pulmão/virologia
Insuficiência de Múltiplos Órgãos/virologia
Choque Séptico/virologia
Doadores de Tecidos
Infecção pelo Vírus da Varicela-Zoster/transmissão
Infecção pelo Vírus da Varicela-Zoster/virologia
[Mh] Termos MeSH secundário: Adulto
Evolução Fatal
Feminino
Seres Humanos
Masculino
Meia-Idade
Insuficiência de Múltiplos Órgãos/diagnóstico
Choque Séptico/diagnóstico
Infecção pelo Vírus da Varicela-Zoster/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1097/TP.0000000000001899


  3 / 5885 MEDLINE  
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[PMID]:27772619
[Au] Autor:Abad CL; Razonable RR
[Ad] Endereço:Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN.
[Ti] Título:α Herpes Virus Infections Among Renal Transplant Recipients.
[So] Source:Semin Nephrol;36(5):344-350, 2016 09.
[Is] ISSN:1558-4488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The α herpes viruses HSV-1, HSV-2, and VZV often reactivate in the setting of immune suppression after solid organ transplantation. Oral or genital mucocutaneous disease is the most common clinical manifestation of HSV disease while VZV manifests as varicella (or chickenpox) or reactivation herpes zoster, characterized by a diffuse rash, or a painful unilateral vesicular eruption in a dermatomal distribution, respectively. The diagnosis of HSV and VZV is primarily based on history and clinical presentation, although diagnostic tests may be necessary for atypical presentations of disease. Treatment usually involves oral or intravenous antiviral therapy, depending on severity of illness.
[Mh] Termos MeSH primário: Varicela/induzido quimicamente
Rejeição de Enxerto/prevenção & controle
Herpes Simples/induzido quimicamente
Herpes Zoster/induzido quimicamente
Imunossupressores/efeitos adversos
Falência Renal Crônica/cirurgia
Transplante de Rim
[Mh] Termos MeSH secundário: Antivirais/uso terapêutico
Varicela/diagnóstico
Varicela/tratamento farmacológico
Varicela/prevenção & controle
Vacina contra Varicela/uso terapêutico
Técnicas de Cultura
Técnica Direta de Fluorescência para Anticorpo
Herpes Simples/diagnóstico
Herpes Simples/tratamento farmacológico
Herpes Zoster/diagnóstico
Herpes Zoster/tratamento farmacológico
Herpes Zoster/prevenção & controle
Herpesvirus Humano 1
Herpesvirus Humano 2
Herpesvirus Humano 3
Seres Humanos
Reação em Cadeia da Polimerase
Testes Sorológicos
Ativação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Chickenpox Vaccine); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  4 / 5885 MEDLINE  
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[PMID]:29402251
[Au] Autor:Kim JY; Lee JH; Lee CS; Lee SC
[Ad] Endereço:Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul, South Korea.
[Ti] Título:Varicella zoster virus-associated Chorioretinitis: a case report.
[So] Source:BMC Ophthalmol;18(1):28, 2018 Feb 05.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained during the course of resolution. CASE PRESENTATION: A 61-year-old woman presented with acute, unilateral vision loss in her right eye. Her visual acuity was count fingers in the right eye and 16/20 in the left eye, and she exhibited skin vesicles on her right forehead. Slit lamp biomicroscopy, funduscopy, OCT, and intraocular fluid analysis were performed. The right eye exhibited multiple inflammatory lesions at the posterior pole, macular edema, and disc swelling on the fundus examination. OCT revealed predominant involvement of the choroid and the retinal pigment epithelium (RPE). Intraocular fluid analysis showed positivity for VZV. The patient was admitted and treated with intravenous acyclovir. Additional oral prednisolone was used to reduce the inflammatory reaction. After 2 weeks of treatment with acyclovir, the lesion resolved, with undulation of the RPE. Her final visual acuity was 20/20. CONCLUSIONS: VZV-associated posterior uveitis may present as multifocal chorioretinitis. Intraocular fluid analysis is important to detect an infectious origin.
[Mh] Termos MeSH primário: Coriorretinite/virologia
Infecções Oculares Virais/virologia
Herpesvirus Humano 3/isolamento & purificação
Uveíte Posterior/virologia
Infecção pelo Vírus da Varicela-Zoster/virologia
[Mh] Termos MeSH secundário: Aciclovir/uso terapêutico
Administração Oral
Antivirais/uso terapêutico
Coriorretinite/diagnóstico
Coriorretinite/tratamento farmacológico
Terapia Combinada
Infecções Oculares Virais/diagnóstico
Infecções Oculares Virais/tratamento farmacológico
Feminino
Angiofluoresceinografia
Glucocorticoides/uso terapêutico
Seres Humanos
Meia-Idade
Prednisolona/uso terapêutico
Tomografia de Coerência Óptica
Uveíte Posterior/diagnóstico
Uveíte Posterior/tratamento farmacológico
Infecção pelo Vírus da Varicela-Zoster/diagnóstico
Infecção pelo Vírus da Varicela-Zoster/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Glucocorticoids); 9PHQ9Y1OLM (Prednisolone); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0696-3


  5 / 5885 MEDLINE  
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[PMID]:28453063
[Au] Autor:Tique V; Mattar S; Freire M; Illian E; Camargo F; Vergara O; Moraes-Figueiredo LT
[Ad] Endereço:Universidad de Cordoba, Monteria, Colombia, overgara@correo.unicordoba.edu.co.
[Ti] Título:Epidemiological surveillance of herpes viral encephalitis in Cordoba, Colombia.
[So] Source:Rev Salud Publica (Bogota);18(4):581-591, 2016 Aug.
[Is] ISSN:0124-0064
[Cp] País de publicação:Colombia
[La] Idioma:eng
[Ab] Resumo:Objective To establish an epidemiological surveillance of viral herpes encephalitis in major hospitals of Monteria, Cordoba. Methods From September 2009 to December 2011, a descriptive study of cases of viral encephalitis was made in three hospitals in the city of Monteria. Cerebrospinal fluid (CSF) samples from 118 patients were included in the study. Clinical aspects, as well as cytochemical and microbiological analysis (Gram stain and culture) of CSF, were used for selecting the patients. Virus detection was performed by using multiplex nested PCR for Herpes simplex virus 1 and 2, Epstein Barr virus, Cytomegalovirus and Varicella zoster virus. Results Viral DNA of herpesvirus was detected in the CSFs of 30 (25.4 %) participants, as follows: 22 (18.6 %) Herpes simplex 1 and 2 viruses, 4 (3.3 %) Cytomegalovirus and 1 (0.8 %) Varicella zoster virus. Co-infections were observed in 3 patients (2.5 %), 1 case by HSV-VZV and 2 cases by CMV/HSV. The clinical manifestations of the patients included: headache (18.6 %), fever (14.4 %), asthenia (10.1 %), seizures (9.3 %), vomiting (8.4 %), and stiff neck (5.9 %). Thirty percent of the patients also had HIV-AIDS. A case fatality rate of 20 % was observed for the patients. Conclusions This paper shows that herpesvirus is a cause of infection of the CNS in patients from Cordoba. This study contributes to the epidemiology of encephalitis, as well as to patient management.
[Mh] Termos MeSH primário: Encefalite Viral/epidemiologia
Infecções por Herpesviridae/epidemiologia
Vigilância da População
[Mh] Termos MeSH secundário: Coinfecção/líquido cefalorraquidiano
Coinfecção/epidemiologia
Coinfecção/virologia
Colômbia/epidemiologia
Citomegalovirus/isolamento & purificação
Infecções por Citomegalovirus/líquido cefalorraquidiano
Infecções por Citomegalovirus/epidemiologia
Encefalite por Herpes Simples/líquido cefalorraquidiano
Encefalite por Herpes Simples/epidemiologia
Encefalite por Varicela Zoster/líquido cefalorraquidiano
Encefalite por Varicela Zoster/epidemiologia
Encefalite Viral/líquido cefalorraquidiano
Infecções por Herpesviridae/líquido cefalorraquidiano
Herpesvirus Humano 3
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  6 / 5885 MEDLINE  
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[PMID]:28454912
[Au] Autor:Pertusati F; Serafini S; Albadry N; Snoeck R; Andrei G
[Ad] Endereço:School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, CF10 3NB, Cardiff, Wales, United Kingdom. Electronic address: pertusatif1@cardiff.ac.uk.
[Ti] Título:Phosphonoamidate prodrugs of C5-substituted pyrimidine acyclic nucleosides for antiviral therapy.
[So] Source:Antiviral Res;143:262-268, 2017 07.
[Is] ISSN:1872-9096
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Acyclic nucleoside phosphonates (ANPs) are nowadays one of the key drugs in the treatment of DNA virus and retrovirus infections. In this work, we report the synthesis and antiviral evaluation of phosphonoamidate and diamidates prodrugs of C5-pyrimidine acyclic nucleosides derivatives functionalized with but-2-enyl- chain. In the phosphonoamidate series, the most active compound 15, showed sub-micromolar activity against varicella zoster virus (VZV) (EC = 0.09-0.5 µM) and µM activity against human cytomegalovirus (HCMV) and herpes simplex virus (HSV). Separation of single diastereoisomers for compound 14, showed that 14b had better anti-herpesvirus activity and no cytotoxicity compared to the diastereoisomeric mixture 14. Very interestingly, phosphonodiamidate 21 showed anti-herpesvirus activity with excellent activity against wild type and thymidine kinase-deficient (TK ) VZV strains (EC = 0.47 and 0.2 µM, respectively) and HCMV (EC = 3.5-7.2 µM) without any cytotoxicity (CC > 100).
[Mh] Termos MeSH primário: Pró-Fármacos/síntese química
Pró-Fármacos/farmacologia
Nucleosídeos de Pirimidina/síntese química
Nucleosídeos de Pirimidina/farmacologia
[Mh] Termos MeSH secundário: Antivirais/síntese química
Antivirais/farmacologia
Linhagem Celular
Citomegalovirus/efeitos dos fármacos
Herpesvirus Humano 3/efeitos dos fármacos
Seres Humanos
Simplexvirus/efeitos dos fármacos
Timidina Quinase
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Prodrugs); 0 (Pyrimidine Nucleosides); EC 2.7.1.21 (Thymidine Kinase)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  7 / 5885 MEDLINE  
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[PMID]:28466551
[Au] Autor:Nilsson J; Granrot I; Mattsson J; Omazic B; Uhlin M; Thunberg S
[Ad] Endereço:Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.
[Ti] Título:Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation.
[So] Source:Vox Sang;112(5):459-468, 2017 Jul.
[Is] ISSN:1423-0410
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Allogeneic hematopoietic stem cell transplantation (HSCT) is a routine clinical procedure performed to treat patients with haematological malignancies, primary immune deficiencies or metabolic disorders. Infections during lymphopenia after allogeneic HSCT are associated with high mortality and morbidity. Typical infectious agents are Epstein-Barr virus, cytomegalovirus, herpes simplex virus, varicella-zoster virus and fungi. The study aim was to evaluate whether measurement of the responses of antigen-specific T-cells, recognizing infectious pathogens would correlate to protective functions in the stem cell recipient post-transplant. MATERIALS AND METHODS: Twenty-one grafts were analysed by flow cytometry and cells were stimulated in vitro with relevant infectious antigens, followed by evaluation of T-cell proliferation and cytokine production. Results were compared to the recipients' clinical records 1-year post-transplantation. RESULTS: We show that an extensive repertoire of transferred antigen-specific T-cells from allogeneic donor grafts against infectious agents, involved in post-transplant infections, are linked to an absence of infectious complications for the recipient up-to 1-year post-transplant. The protective effect was associated with antigen-specific T-cell proliferation and IL-1ß secretion. CONCLUSION: Our results suggest that assaying T-cell function before HSCT could determine individual risks for infectious complications and thus aid in clinical decision-making regarding prophylactic and pre-emptive anti-infective therapy.
[Mh] Termos MeSH primário: Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Células-Tronco Hematopoéticas/fisiologia
Viroses/prevenção & controle
[Mh] Termos MeSH secundário: Adenoviridae/imunologia
Adolescente
Adulto
Idoso
Candida/imunologia
Criança
Pré-Escolar
Citomegalovirus/imunologia
Feminino
Citometria de Fluxo
Neoplasias Hematológicas/terapia
Herpesvirus Humano 3/imunologia
Herpesvirus Humano 4/imunologia
Seres Humanos
Lactente
Controle de Infecções/métodos
Contagem de Leucócitos
Ativação Linfocitária
Masculino
Meia-Idade
Simplexvirus/imunologia
Linfócitos T/imunologia
Linfócitos T/virologia
Transplante Homólogo/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/vox.12521


  8 / 5885 MEDLINE  
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[PMID]:28747504
[Au] Autor:Cohrs RJ; Lee KS; Beach A; Sanford B; Baird NL; Como C; Graybill C; Jones D; Tekeste E; Ballard M; Chen X; Yalacki D; Frietze S; Jones K; Lenac Rovis T; Jonjic S; Haas J; Gilden D
[Ad] Endereço:Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA randall.cohrs@ucdenver.edu.
[Ti] Título:Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion.
[So] Source:J Virol;91(20), 2017 Oct 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The neurotropic herpesvirus varicella-zoster virus (VZV) establishes a lifelong latent infection in humans following primary infection. The low abundance of VZV nucleic acids in human neurons has hindered an understanding of the mechanisms that regulate viral gene transcription during latency. To overcome this critical barrier, we optimized a targeted capture protocol to enrich VZV DNA and cDNA prior to whole-genome/transcriptome sequence analysis. Since the VZV genome is remarkably stable, it was surprising to detect that VZV32, a VZV laboratory strain with no discernible growth defect in tissue culture, contained a 2,158-bp deletion in open reading frame (ORF) 12. Consequently, ORF 12 and 13 protein expression was abolished and Akt phosphorylation was inhibited. The discovery of the ORF 12 deletion, revealed through targeted genome sequencing analysis, points to the need to authenticate the VZV genome when the virus is propagated in tissue culture. Viruses isolated from clinical samples often undergo genetic modifications when cultured in the laboratory. Historically, VZV is among the most genetically stable herpesviruses, a notion supported by more than 60 complete genome sequences from multiple isolates and following multiple passages. However, application of enrichment protocols to targeted genome sequencing revealed the unexpected deletion of a significant portion of VZV ORF 12 following propagation in cultured human fibroblast cells. While the enrichment protocol did not introduce bias in either the virus genome or transcriptome, the findings indicate the need for authentication of VZV by sequencing when the virus is propagated in tissue culture.
[Mh] Termos MeSH primário: DNA Viral/isolamento & purificação
Genoma Viral
Herpesvirus Humano 3/genética
Fases de Leitura Aberta
Deleção de Sequência
[Mh] Termos MeSH secundário: Linhagem Celular
DNA Complementar
Herpesvirus Humano 3/crescimento & desenvolvimento
Seres Humanos
Análise de Sequência de DNA/métodos
Transcriptoma
Proteínas Virais
Vírion
Latência Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (DNA, Viral); 0 (Viral Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171208
[Lr] Data última revisão:
171208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


  9 / 5885 MEDLINE  
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[PMID]:28748773
[Au] Autor:Jin L; Xu S; Maple PAC; Xu W; Brown KE
[Ad] Endereço:Virus Reference Department,National Infections Service,Public Health England,London,UK.
[Ti] Título:Differentiation between wild-type and vaccines strains of varicella zoster virus (VZV) based on four single nucleotide polymorphisms.
[So] Source:Epidemiol Infect;145(12):2618-2625, 2017 09.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Varicella-zoster virus (VZV) infection (chickenpox) results in latency and subsequent reactivation manifests as shingles. Effective attenuated vaccines (vOka) are available for prevention of both illnesses. In this study, an amplicon-based sequencing method capable of differentiating between VZV wild-type (wt) strains and vOka vaccine is described. A total of 44 vesicular fluid specimens collected from 43 patients (16 from China and 27 from the UK) with either chickenpox or shingles were investigated, of which 10 had received previous vaccination. Four sets of polymerase chain reactions were set up simultaneously with primers amplifying regions encompassing four single nucleotide polymorphisms (SNPs), '69349-106262-107252-108111'. Nucleotide sequences were generated by Sanger sequencing. All samples except one had a wt SNP profile of 'A-T-T-T'. The sample collected from a patient who received vaccine 7-10 days ago, along with VZV vaccine preparations, Zostavax and Baike-varicella gave a SNP profile 'G-C-C-C'. The results show that this method can distinguish vaccine-derived virus from wt viruses from main four clades, (clades 1-4) and should be of utility worldwide.
[Mh] Termos MeSH primário: Vacina contra Varicela/genética
Herpesvirus Humano 3/genética
Reação em Cadeia da Polimerase
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Varicela/virologia
Vacina contra Varicela/classificação
Criança
Pré-Escolar
China
Inglaterra
Feminino
Herpes Zoster/virologia
Herpesvirus Humano 3/classificação
Seres Humanos
Lactente
Masculino
Meia-Idade
Escócia
Análise de Sequência de DNA
Vacinas Atenuadas/classificação
Vacinas Atenuadas/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chickenpox Vaccine); 0 (Vaccines, Attenuated)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817001509


  10 / 5885 MEDLINE  
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[PMID]:28910710
[Au] Autor:Wang W; Yang L; Huang X; Fu W; Pan D; Cai L; Ye J; Liu J; Xia N; Cheng T; Zhu H
[Ad] Endereço:State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, PR China.
[Ti] Título:Outer nuclear membrane fusion of adjacent nuclei in varicella-zoster virus-induced syncytia.
[So] Source:Virology;512:34-38, 2017 Dec.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Syncytia formation has been considered important for cell-to-cell spread and pathogenesis of many viruses. As a syncytium forms, individual nuclei often congregate together, allowing close contact of nuclear membranes and possibly fusion to occur. However, there is currently no reported evidence of nuclear membrane fusion between adjacent nuclei in wild-type virus-induced syncytia. Varicella-zoster virus (VZV) is one typical syncytia-inducing virus that causes chickenpox and shingles in humans. Here, we report, for the first time, an interesting observation of apparent fusion of the outer nuclear membranes from juxtaposed nuclei that comprise VZV syncytia both in ARPE-19 human epithelial cells in vitro and in human skin xenografts in the SCID-hu mouse model in vivo. This work reveals a novel aspect of VZV-related cytopathic effect in the context of multinucleated syncytia. Additionally, the information provided by this study could be helpful for future studies on interactions of viruses with host cell nuclei.
[Mh] Termos MeSH primário: Células Epiteliais/patologia
Células Epiteliais/virologia
Células Gigantes/virologia
Herpesvirus Humano 3/fisiologia
Membrana Nuclear/patologia
[Mh] Termos MeSH secundário: Fusão Celular
Linhagem Celular
Seres Humanos
Membrana Nuclear/virologia
Pele/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE



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