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[PMID]: 27772620 [Au] Autor: Santos CA [Ad] Endereço: Rush University Medical Center, Chicago, IL. Electronic address: Carlos_A_Santos@rush.edu. [Ti] Título: Cytomegalovirus and Other ß-Herpesviruses. [So] Source: Semin Nephrol;36(5):351-361, 2016 09. [Is] ISSN: 1558-4488 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Cytomegalovirus (CMV), human herpes virus (HHV)-6, and HHV-7 are ubiquitous ß-herpesviruses that can cause opportunistic infection and disease in kidney transplant recipients. Active CMV infection and disease are associated with acute allograft failure and death, and HHV-6 and HHV-7 replication are associated with CMV disease. CMV prevention strategies are used commonly after kidney transplantation, and include prophylaxis with antiviral medications and preemptive treatment upon the detection of asymptomatic viral replication in blood. Both approaches decrease CMV disease and allograft rejection, but CMV prophylaxis is preferred for high-risk patients because it is easy to administer and may be more effective in real-world settings. CMV disease commonly occurs even with current preventive strategies, whereas HHV-6 and HHV-7 diseases are rare. The clinical manifestations of CMV, HHV-6, and HHV-7 are nonspecific, and laboratory confirmation is essential to establishing diagnoses. Although nucleic acid testing has supplanted other diagnostic modalities given its high sensitivity and specificity, histopathologic examination sometimes is necessary to identify disease definitively. Ganciclovir and valganciclovir are the treatments of choice for CMV and HHV-6, and foscarnet can be used to treat HHV-7. Treatment duration should be informed by the initial severity of disease, and subsequent clinical and virologic responses. [Mh] Termos MeSH primário: Infecções por Citomegalovirus/induzido quimicamente Rejeição de Enxerto/prevenção & controle Imunossupressores/efeitos adversos Falência Renal Crônica/cirurgia Transplante de Rim Infecções por Roseolovirus/induzido quimicamente [Mh] Termos MeSH secundário: Antivirais/uso terapêutico Infecções por Citomegalovirus/diagnóstico Infecções por Citomegalovirus/tratamento farmacológico Ganciclovir/análogos & derivados Ganciclovir/uso terapêutico Herpesvirus Humano 6 Herpesvirus Humano 7 Seres Humanos Infecções por Roseolovirus/diagnóstico Infecções por Roseolovirus/tratamento farmacológico [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Antiviral Agents); 0 (Immunosuppressive Agents); GCU97FKN3R (valganciclovir); P9G3CKZ4P5 (Ganciclovir) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 29443669 [Au] Autor: El-Jawahri AR; Schaefer PW; El Khoury JB; Martinez-Lage M [Ad] Endereço: From the Departments of Medicine (A.R.E.-J., J.B.E.K.), Radiology (P.W.S.), and Pathology (M.M.-L.), Massachusetts General Hospital, and the Departments of Medicine (A.R.E.-J., J.B.E.K.), Radiology (P.W.S.), and Pathology (M.M.-L.), Harvard Medical School - both in Boston. [Ti] Título: Case 5-2018: A 63-Year-Old Man with Confusion after Stem-Cell Transplantation. [So] Source: N Engl J Med;378(7):659-669, 2018 Feb 15. [Is] ISSN: 1533-4406 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Confusão/etiologia Transplante de Células-Tronco Hematopoéticas/efeitos adversos Herpesvirus Humano 6/isolamento & purificação Hospedeiro Imunocomprometido Meningoencefalite/diagnóstico Infecções por Roseolovirus/diagnóstico [Mh] Termos MeSH secundário: Antivirais/uso terapêutico Autopsia Diagnóstico Diferencial Evolução Fatal Foscarnet/uso terapêutico Reação Enxerto-Hospedeiro Seres Humanos Leucemia Linfocítica Crônica de Células B/terapia Masculino Meningoencefalite/complicações Meningoencefalite/virologia Meia-Idade Infecções por Roseolovirus/complicações Infecções por Roseolovirus/tratamento farmacológico Transplante Homólogo [Pt] Tipo de publicação: CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antiviral Agents); 364P9RVW4X (Foscarnet) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180215 [St] Status: MEDLINE [do] DOI: 10.1056/NEJMcpc1707556

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[PMID]: 27777240 [Au] Autor: Gravel A; Dubuc I; Brooks-Wilson A; Aronson KJ; Simard J; Velásquez-García HA; Spinelli JJ; Flamand L [Ad] Endereço: Division of Infectious Disease and Immunity, CHU de Québec Research Center and Department of Microbiology-Infectious Disease, Quebec, Canada. [Ti] Título: Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer. [So] Source: Cancer Epidemiol Biomarkers Prev;26(3):425-427, 2017 Mar. [Is] ISSN: 1538-7755 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) is a condition observed in approximately 1% of the population. Whether such a genetic alteration predisposes to cancer development in currently unknown. Two studies were conducted to determine whether iciHHV-6 is associated with cancer development. First, a screen of 19,597 people from the province of Quebec (Canada) was conducted. A replication test, using data from a population-based case-control study of 1,090 women with incident breast cancer and 1,053 controls from British Columbia and Ontario (Canada) was conducted. DNA samples were analyzed by qPCR and droplet digital PCR to identify iciHHV-6 carriers. In the initial study, a potential association between iciHHV-6 positivity and breast cancer was identified [OR = 2.66; 95% confidence interval (CI), 0.95-7.44]. In the replication dataset, no association was found between iciHHV-6 positivity in women and breast cancer (OR = 0.87; 95% CI, 0.35-2.15). We found no statistically significant associations between inherited chromosomally integrated HHV-6 and breast cancer in women. These results do not provide evidence to suggest that iciHHV-6 is a risk factor for breast cancer. . [Mh] Termos MeSH primário: Neoplasias da Mama/genética Herpesvirus Humano 6/genética Integração Viral/genética [Mh] Termos MeSH secundário: Idoso Idoso de 80 Anos ou mais Neoplasias da Mama/epidemiologia Colúmbia Britânica Estudos de Casos e Controles Estudos de Coortes Feminino Predisposição Genética para Doença Genoma Viral Estudo de Associação Genômica Ampla Seres Humanos Masculino Meia-Idade Ontário Vigilância da População Prevalência Quebeque Fatores de Risco [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180212 [Lr] Data última revisão: 180212 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161026 [St] Status: MEDLINE [do] DOI: 10.1158/1055-9965.EPI-16-0735

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[PMID]: 28468887 [Au] Autor: Gilbert-Girard S; Gravel A; Artusi S; Richter SN; Wallaschek N; Kaufer BB; Flamand L [Ad] Endereço: Division of Infectious and Immune Diseases, CHU de Québec Research Center, Quebec City, Quebec, Canada. [Ti] Título: Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration. [So] Source: J Virol;91(14), 2017 Jul 15. [Is] ISSN: 1098-5514 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Human herpesviruses 6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes using a mechanism that remains poorly understood. To achieve a better understanding of the HHV-6A/B integration mechanism, we made use of BRACO-19, a compound that stabilizes G-quadruplex secondary structures and prevents telomere elongation by the telomerase complex. First, we analyzed the folding of telomeric sequences into G-quadruplex structures and their binding to BRACO-19 using G-quadruplex-specific antibodies and surface plasmon resonance. Circular dichroism studies indicate that BRACO-19 modifies the conformation and greatly stabilizes the G-quadruplexes formed in G-rich telomeric DNA. Subsequently we assessed the effects of BRACO-19 on the HHV-6A initial phase of infection. Our results indicate that BRACO-19 does not affect entry of HHV-6A DNA into cells. We next investigated if stabilization of G-quadruplexes by BRACO-19 affected HHV-6A's ability to integrate its genome into host chromosomes. Incubation of telomerase-expressing cells with BRACO-19, such as HeLa and MCF-7, caused a significant reduction in the HHV-6A integration frequency ( < 0.002); in contrast, BRACO-19 had no effect on HHV-6 integration frequency in U2OS cells that lack telomerase activity and elongate their telomeres through alternative lengthening mechanisms. Our data suggest that the fluidity of telomeres is important for efficient chromosomal integration of HHV-6A and that interference with telomerase activity negatively affects the generation of cellular clones containing integrated HHV-6A. HHV-6A/B can integrate their genomes into the telomeres of infected cells. Telomeres consist of repeated hexanucleotides (TTAGGG) of various lengths (up to several kilobases) and end with a single-stranded 3' extension. To avoid recognition and induce a DNA damage response, the single-stranded overhang folds back on itself and forms a telomeric loop (T-loop) or adopts a tertiary structure, referred to as a G-quadruplex. In the current study, we have examined the effects of a G-quadruplex binding and stabilizing agent, BRACO-19, on HHV-6A chromosomal integration. By stabilizing G-quadruplex structures, BRACO-19 affects the ability of the telomerase complex to elongate telomeres. Our results indicate that BRACO-19 reduces the number of clones harboring integrated HHV-6A. This study is the first of its kind and suggests that telomerase activity is essential to restore a functional telomere of adequate length following HHV-6A integration. [Mh] Termos MeSH primário: Quadruplex G Herpesvirus Humano 6/fisiologia Conformação de Ácido Nucleico Telômero/química Telômero/metabolismo Integração Viral [Mh] Termos MeSH secundário: Acridinas/metabolismo Linhagem Celular Dicroísmo Circular Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Acridines); Z7C5CD91WI (BRACO-19) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 171226 [Lr] Data última revisão: 171226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE

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[PMID]: 28468878 [Au] Autor: Gravel A; Dubuc I; Wallaschek N; Gilbert-Girard S; Collin V; Hall-Sedlak R; Jerome KR; Mori Y; Carbonneau J; Boivin G; Kaufer BB; Flamand L [Ad] Endereço: Division of Infectious and Immune Diseases, CHU de Quebec Research Center, Quebec City, Canada. [Ti] Título: Cell Culture Systems To Study Human Herpesvirus 6A/B Chromosomal Integration. [So] Source: J Virol;91(14), 2017 Jul 15. [Is] ISSN: 1098-5514 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Human herpesviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telomeres of human chromosomes. The viral and cellular factors contributing to HHV-6A/B integration remain largely unknown, mostly due to the lack of efficient and reproducible cell culture models to study HHV-6A/B integration. In this study, we characterized the HHV-6A/B integration efficiencies in several human cell lines using two different approaches. First, after a short-term infection (5 h), cells were processed for single-cell cloning and analyzed for chromosomally integrated HHV-6A/B (ciHHV-6A/B). Second, cells were infected with HHV-6A/B and allowed to grow in bulk for 4 weeks or longer and then analyzed for the presence of ciHHV-6. Using quantitative PCR (qPCR), droplet digital PCR, and fluorescent hybridization, we could demonstrate that HHV-6A/B integrated in most human cell lines tested, including telomerase-positive (HeLa, MCF-7, HCT-116, and HEK293T) and telomerase-negative cell lines (U2OS and GM847). Our results also indicate that inhibition of DNA replication, using phosphonoacetic acid, did not affect HHV-6A/B integration. Certain clones harboring ciHHV-6A/B spontaneously express viral genes and proteins. Treatment of cells with phorbol ester or histone deacetylase inhibitors triggered the expression of many viral genes, including , , and , without the production of infectious virus, suggesting that the tested stimuli were not sufficient to trigger full reactivation. In summary, both integration models yielded comparable results and should enable the identification of viral and cellular factors contributing to HHV-6A/B integration and the screening of drugs influencing viral gene expression, as well as the release of infectious HHV-6A/B from the integrated state. The analysis and understanding of HHV-6A/B genome integration into host DNA is currently limited due to the lack of reproducible and efficient viral integration systems. In the present study, we describe two quantitative cell culture viral integration systems. These systems can be used to define cellular and viral factors that play a role in HHV-6A/B integration. Furthermore, these systems will allow us to decipher the conditions resulting in virus gene expression and excision of the integrated viral genome resulting in reactivation. [Mh] Termos MeSH primário: Herpesvirus Humano 6/fisiologia Cultura de Vírus/métodos Integração Viral [Mh] Termos MeSH secundário: Técnicas de Cultura de Células/métodos Linhagem Celular Seres Humanos Hibridização in Situ Fluorescente Reação em Cadeia da Polimerase em Tempo Real [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 171226 [Lr] Data última revisão: 171226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE

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[PMID]: 28931225 [Au] Autor: Dowd JB; Bosch JA; Steptoe A; Jayabalasingham B; Lin J; Yolken R; Aiello AE [Ad] Endereço: Department of Global Health and Social Medicine, King's College London. [Ti] Título: Persistent Herpesvirus Infections and Telomere Attrition Over 3 Years in the Whitehall II Cohort. [So] Source: J Infect Dis;216(5):565-572, 2017 Sep 01. [Is] ISSN: 1537-6613 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The determinants of telomere attrition, a potential marker of cellular aging, are not well understood. Persistent herpesvirus infections including cytomegalovirus (CMV) infection may be particularly important for telomere dynamics via mechanisms such as inflammation, oxidative stress, and their impact on peripheral blood lymphocyte composition. This study examined the association of 4 human herpesviruses (CMV, herpes simplex virus type 1, human herpesvirus type 6, and Epstein-Barr virus) with change in leukocyte telomere length (LTL) over 3 years in 400 healthy individuals (aged 53-76 years) from the Whitehall II cohort. CMV, herpes simplex virus type 1, and human herpesvirus 6 infection were independently associated with greater 3-year LTL attrition, with no association found for Epstein-Barr virus. The magnitudes of these associations were large, for example, the equivalent of almost 12 years of chronological age for those CMV seropositive. Seropositivity to more herpesviruses was additively associated with greater LTL attrition (3 herpesviruses vs none, ß = -0.07 and P = .02; 4 infections vs none, ß = -0.14 and P < .001). Higher immunoglobulin G antibody levels among those seropositive to CMV were also associated with shorter LTL at follow-up. These associations were robust to adjustment for age, sex, employment grade, body mass index, and smoking status. These results suggest that exposure to infectious agents should be an important consideration in future studies of telomere dynamics. [Mh] Termos MeSH primário: Senescência Celular Infecções por Herpesviridae/diagnóstico Encurtamento do Telômero Telômero/metabolismo [Mh] Termos MeSH secundário: Idoso Formação de Anticorpos Índice de Massa Corporal Estudos de Coortes Citomegalovirus Feminino Seguimentos Herpesvirus Humano 1 Herpesvirus Humano 4 Herpesvirus Humano 6 Seres Humanos Imunoglobulina G/sangue Leucócitos/virologia Masculino Meia-Idade Análise Multivariada Análise de Regressão Sensibilidade e Especificidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Immunoglobulin G) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170922 [St] Status: MEDLINE [do] DOI: 10.1093/infdis/jix255

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[PMID]: 28835501 [Au] Autor: Zhang E; Bell AJ; Wilkie GS; Suárez NM; Batini C; Veal CD; Armendáriz-Castillo I; Neumann R; Cotton VE; Huang Y; Porteous DJ; Jarrett RF; Davison AJ; Royle NJ [Ad] Endereço: Department of Genetics, University of Leicester, Leicester, United Kingdom. [Ti] Título: Inherited Chromosomally Integrated Human Herpesvirus 6 Genomes Are Ancient, Intact, and Potentially Able To Reactivate from Telomeres. [So] Source: J Virol;91(22), 2017 Nov 15. [Is] ISSN: 1098-5514 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The genomes of human herpesvirus 6A (HHV-6A) and HHV-6B have the capacity to integrate into telomeres, the essential capping structures of chromosomes that play roles in cancer and ageing. About 1% of people worldwide are carriers of chromosomally integrated HHV-6 (ciHHV-6), which is inherited as a genetic trait. Understanding the consequences of integration for the evolution of the viral genome, for the telomere, and for the risk of disease associated with carrier status is hampered by a lack of knowledge about ciHHV-6 genomes. Here, we report an analysis of 28 ciHHV-6 genomes and show that they are significantly divergent from the few modern nonintegrated HHV-6 strains for which complete sequences are currently available. In addition, ciHHV-6B genomes in Europeans are more closely related to each other than to ciHHV-6B genomes from China and Pakistan, suggesting regional variation of the trait. Remarkably, at least one group of European ciHHV-6B carriers has inherited the same ciHHV-6B genome, integrated in the same telomere allele, from a common ancestor estimated to have existed 24,500 ± 10,600 years ago. Despite the antiquity of some, and possibly most, germ line HHV-6 integrations, the majority of ciHHV-6B (95%) and ciHHV-6A (72%) genomes contain a full set of intact viral genes and therefore appear to have the capacity for viral gene expression and full reactivation. Inheritance of HHV-6A or HHV-6B integrated into a telomere occurs at a low frequency in most populations studied to date, but its characteristics are poorly understood. However, stratification of ciHHV-6 carriers in modern populations due to common ancestry is an important consideration for genome-wide association studies that aim to identify disease risks for these people. Here, we present full sequence analysis of 28 ciHHV-6 genomes and show that ciHHV-6B in many carriers with European ancestry most likely originated from ancient integration events in a small number of ancestors. We propose that ancient ancestral origins for ciHHV-6A and ciHHV-6B are also likely in other populations. Moreover, despite their antiquity, all of the ciHHV-6 genomes appear to retain the capacity to express viral genes, and most are predicted to be capable of full viral reactivation. These discoveries represent potentially important considerations in immunocompromised patients, in particular in organ transplantation and in stem cell therapy. [Mh] Termos MeSH primário: Cromossomos Humanos Genoma Humano Herpesvirus Humano 6/genética Característica Quantitativa Herdável Telômero Integração Viral/genética [Mh] Termos MeSH secundário: Cromossomos Humanos/genética Cromossomos Humanos/virologia Feminino Estudo de Associação Genômica Ampla Seres Humanos Masculino Telômero/genética Telômero/virologia [Pt] Tipo de publicação: CLINICAL TRIAL; JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171102 [Lr] Data última revisão: 171102 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170825 [St] Status: MEDLINE

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[PMID]: 28783452 [Au] Autor: Tzannou I; Papadopoulou A; Naik S; Leung K; Martinez CA; Ramos CA; Carrum G; Sasa G; Lulla P; Watanabe A; Kuvalekar M; Gee AP; Wu MF; Liu H; Grilley BJ; Krance RA; Gottschalk S; Brenner MK; Rooney CM; Heslop HE; Leen AM; Omer B [Ad] Endereço: Ifigeneia Tzannou, Anastasia Papadopoulou, Swati Naik, Kathryn Leung, Caridad A. Martinez, Carlos A. Ramos, George Carrum, Ghadir Sasa, Premal Lulla, Ayumi Watanabe, Manik Kuvalekar, Adrian P. Gee, Bambi J. Grilley, Robert A. Krance, Stephen Gottschalk, Malcolm K. Brenner, Cliona M. Rooney, Helen E. [Ti] Título: Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation. [So] Source: J Clin Oncol;35(31):3547-3557, 2017 Nov 01. [Is] ISSN: 1527-7755 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Purpose Improvement of cure rates for patients treated with allogeneic hematopoietic stem-cell transplantation (HSCT) will require efforts to decrease treatment-related mortality from severe viral infections. Adoptively transferred virus-specific T cells (VSTs) generated from eligible, third-party donors could provide broad antiviral protection to recipients of HSCT as an immediately available off-the-shelf product. Patient and Methods We generated a bank of VSTs that recognized five common viral pathogens: Epstein-Barr virus (EBV), adenovirus (AdV), cytomegalovirus (CMV), BK virus (BKV), and human herpesvirus 6 (HHV-6). The VSTs were administered to 38 patients with 45 infections in a phase II clinical trial. Results A single infusion produced a cumulative complete or partial response rate of 92% (95% CI, 78.1% to 98.3%) overall and the following rates by virus: 100% for BKV (n = 16), 94% for CMV (n = 17), 71% for AdV (n = 7), 100% for EBV (n = 2), and 67% for HHV-6 (n = 3). Clinical benefit was achieved in 31 patients treated for one infection and in seven patients treated for multiple coincident infections. Thirteen of 14 patients treated for BKV-associated hemorrhagic cystitis experienced complete resolution of gross hematuria by week 6. Infusions were safe, and only two occurrences of de novo graft-versus host disease (grade 1) were observed. VST tracking by epitope profiling revealed persistence of functional VSTs of third-party origin for up to 12 weeks. Conclusion The use of banked VSTs is a feasible, safe, and effective approach to treat severe and drug-refractory infections after HSCT, including infections from two viruses (BKV and HHV-6) that had never been targeted previously with an off-the-shelf product. Furthermore, the multispecificity of the VSTs ensures extensive antiviral coverage, which facilitates the treatment of patients with multiple infections. [Mh] Termos MeSH primário: Infecções por Vírus de DNA/terapia Vírus de DNA/imunologia Transplante de Células-Tronco Hematopoéticas/efeitos adversos Transplante de Células-Tronco Hematopoéticas/métodos Imunoterapia Adotiva/métodos Linfócitos T/imunologia Linfócitos T/transplante [Mh] Termos MeSH secundário: Adenovírus Humanos/imunologia Adulto Vírus BK/imunologia Infecções por Vírus de DNA/etiologia Infecções por Vírus de DNA/virologia Feminino Herpesvirus Humano 4/imunologia Herpesvirus Humano 6/imunologia Seres Humanos Masculino Transplante Homólogo Resultado do Tratamento [Pt] Tipo de publicação: CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171117 [Lr] Data última revisão: 171117 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170808 [St] Status: MEDLINE [do] DOI: 10.1200/JCO.2017.73.0655

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[PMID]: 28728872 [Au] Autor: Ciccarese G; Broccolo F; Rebora A; Parodi A; Drago F [Ad] Endereço: DISSAL Department of Dermatology, IRCCS AOU San Martino-IST, Genoa, Italy. Electronic address: giuliaciccarese@libero.it. [Ti] Título: Oropharyngeal lesions in pityriasis rosea. [So] Source: J Am Acad Dermatol;77(5):833-837.e4, 2017 Nov. [Is] ISSN: 1097-6787 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence. OBJECTIVE: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms. METHODS: The records of all PR cases diagnosed in the Dermatology Clinic of Genoa University between 2003 and 2016 were retrospectively reviewed to examine sex and age of the patients, PR type, presence of enanthema, systemic symptoms, specific anti-HHV-6 and or HHV-7 serology, and HHV-6 and/or HHV-7 DNA loads. RESULTS: The oropharyngeal mucosa was carefully examined in 527 patients with PR. Painless oropharyngeal lesions were observed in 149 patients with PR (28%) and classified as erythematomacular, macular and papular, erythematovesicular, and petechial lesions. The petechial and macular and papular patterns were those most frequently observed. There was no statistically significant difference in the levels of HHV-6 and HHV-7 viremia in the plasma of patients with enanthema and those without. LIMITATIONS: Because this was a retrospective study, biopsies on mucosal lesions were not performed. CONCLUSION: Our findings showed that enanthemas are frequently associated with forms of PR different from the classic form. [Mh] Termos MeSH primário: Doenças da Boca/epidemiologia Doenças Faríngeas/virologia Pitiríase Rósea/epidemiologia Pitiríase Rósea/virologia [Mh] Termos MeSH secundário: Adulto Distribuição por Idade Criança Pré-Escolar Estudos de Coortes Feminino Herpesvirus Humano 6/isolamento & purificação Herpesvirus Humano 7/isolamento & purificação Seres Humanos Masculino Meia-Idade Doenças da Boca/fisiopatologia Doenças da Boca/virologia Mucosa Bucal/fisiopatologia Mucosa Bucal/virologia Doenças Faríngeas/epidemiologia Doenças Faríngeas/fisiopatologia Faringe/fisiopatologia Faringe/virologia Pitiríase Rósea/patologia Prevalência Prognóstico Sistema de Registros Estudos Retrospectivos Medição de Risco Distribuição por Sexo [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171102 [Lr] Data última revisão: 171102 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170722 [St] Status: MEDLINE

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[PMID]: 28699856 [Au] Autor: Kawamura Y; Ohye T; Miura H; Ihira M; Kato Y; Kurahashi H; Yoshikawa T [Ad] Endereço: 1​Department of Pediatrics, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan †â€‹Present address: Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administra [Ti] Título: Analysis of the origin of inherited chromosomally integrated human herpesvirus 6 in the Japanese population. [So] Source: J Gen Virol;98(7):1823-1830, 2017 Jul. [Is] ISSN: 1465-2099 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Integration of the complete human herpesvirus 6 (HHV-6) genome into the telomere of a chromosome has been reported in some individuals (inherited chromosomally integrated HHV-6; iciHHV-6). Since the proportion of iciHHV-6-positive individuals with integration in chromosome 22 is high in Japan, we hypothesized a founder effect. In this study, we sought to elucidate the reason for the high proportion of viral integrations into chromosome 22. We analyzed six cases of iciHHV-6A and two cases of iciHHV-6B, including one iciHHV-6A case with a matched sample from a father and one iciHHV-6B case with a matched sample from a mother. In iciHHV-6A, the same copy numbers of viral telomeric repeat sequences (TRS) and the same five microsatellite markers were detected in both the index case and paternal sample. Moreover, the same five microsatellite markers were demonstrated in four cases and the same copy numbers of viral TRS were demonstrated in two pairs of two cases. The present microsatellite analysis suggested that the viral genomes detected in some iciHHV-6A patients were derived from a common ancestral integration. [Mh] Termos MeSH primário: Cromossomos Humanos Par 22/virologia Herpesvirus Humano 6/isolamento & purificação Infecções por Roseolovirus/virologia [Mh] Termos MeSH secundário: Adulto Cromossomos Humanos Par 22/genética Feminino Genoma Viral Herpesvirus Humano 6/classificação Herpesvirus Humano 6/genética Herpesvirus Humano 6/fisiologia Seres Humanos Japão Masculino Sequências Repetitivas de Ácido Nucleico Infecções por Roseolovirus/congênito Infecções por Roseolovirus/genética Integração Viral [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170921 [Lr] Data última revisão: 170921 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170713 [St] Status: MEDLINE [do] DOI: 10.1099/jgv.0.000834

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