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[PMID]:27772620
[Au] Autor:Santos CA
[Ad] Endereço:Rush University Medical Center, Chicago, IL. Electronic address: Carlos_A_Santos@rush.edu.
[Ti] Título:Cytomegalovirus and Other ß-Herpesviruses.
[So] Source:Semin Nephrol;36(5):351-361, 2016 09.
[Is] ISSN:1558-4488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cytomegalovirus (CMV), human herpes virus (HHV)-6, and HHV-7 are ubiquitous ß-herpesviruses that can cause opportunistic infection and disease in kidney transplant recipients. Active CMV infection and disease are associated with acute allograft failure and death, and HHV-6 and HHV-7 replication are associated with CMV disease. CMV prevention strategies are used commonly after kidney transplantation, and include prophylaxis with antiviral medications and preemptive treatment upon the detection of asymptomatic viral replication in blood. Both approaches decrease CMV disease and allograft rejection, but CMV prophylaxis is preferred for high-risk patients because it is easy to administer and may be more effective in real-world settings. CMV disease commonly occurs even with current preventive strategies, whereas HHV-6 and HHV-7 diseases are rare. The clinical manifestations of CMV, HHV-6, and HHV-7 are nonspecific, and laboratory confirmation is essential to establishing diagnoses. Although nucleic acid testing has supplanted other diagnostic modalities given its high sensitivity and specificity, histopathologic examination sometimes is necessary to identify disease definitively. Ganciclovir and valganciclovir are the treatments of choice for CMV and HHV-6, and foscarnet can be used to treat HHV-7. Treatment duration should be informed by the initial severity of disease, and subsequent clinical and virologic responses.
[Mh] Termos MeSH primário: Infecções por Citomegalovirus/induzido quimicamente
Rejeição de Enxerto/prevenção & controle
Imunossupressores/efeitos adversos
Falência Renal Crônica/cirurgia
Transplante de Rim
Infecções por Roseolovirus/induzido quimicamente
[Mh] Termos MeSH secundário: Antivirais/uso terapêutico
Infecções por Citomegalovirus/diagnóstico
Infecções por Citomegalovirus/tratamento farmacológico
Ganciclovir/análogos & derivados
Ganciclovir/uso terapêutico
Herpesvirus Humano 6
Herpesvirus Humano 7
Seres Humanos
Infecções por Roseolovirus/diagnóstico
Infecções por Roseolovirus/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Immunosuppressive Agents); GCU97FKN3R (valganciclovir); P9G3CKZ4P5 (Ganciclovir)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  2 / 595 MEDLINE  
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[PMID]:28804113
[Au] Autor:Takahashi K; Sato H; Hattori H; Takao M; Takahashi S; Suzuki N
[Ad] Endereço:Department of Neurology, Saitama Municipal Hospital.
[Ti] Título:Case report of a 28-year-old male with the rapid progression of steroid-resistant central nervous system vasculitis diagnosed by a brain biopsy.
[So] Source:Rinsho Shinkeigaku;57(9):509-514, 2017 09 30.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 28-year-old Japanese male without a significant past medical history presented with new-onset generalized clonic seizure and headache. A brain MRI revealed multiple enhanced lesions on both cerebral hemispheres. Laboratory exams showed no evidence of systemic inflammation or auto-immune antibodies such as ANCAs. Despite four courses of high-dose methylprednisolone pulse therapy and five treatments with plasmapheresis, his symptoms worsened and the MRI lesions progressed rapidly. During these treatments, we performed a targeted brain biopsy, that revealed histological findings consistent with a predominant angiitis of parenchymal and subdural small vessels. He was provided with diagnosis of central nervous system vasculitis (CNSV). Subsequent cyclophosphamide pulse therapy enabled a progressive successful improvement of his symptoms. While diagnostic methods for CNSV remain controversial, histological findings are thought to be more useful in obtaining a more definitive diagnosis than findings in image studies, such as MRI and angiography. We suggest that a brain biopsy should be considered during the early period of cases with suspected CNSV and rapid clinical deterioration. We also detected human herpesvirus 7 (HHV-7) using PCR technology in brain biopsy specimens, however the relationship between CNSV and HHV-7 infection is unknow.
[Mh] Termos MeSH primário: Biópsia
Encéfalo/patologia
Vasculite do Sistema Nervoso Central/diagnóstico
Vasculite do Sistema Nervoso Central/patologia
[Mh] Termos MeSH secundário: Adulto
Encéfalo/virologia
Ciclofosfamida/administração & dosagem
Imagem de Difusão por Ressonância Magnética
Progressão da Doença
Quimioterapia Combinada
Herpesvirus Humano 7/isolamento & purificação
Seres Humanos
Masculino
Metilprednisolona/administração & dosagem
Troca Plasmática
Prednisolona/administração & dosagem
Pulsoterapia
Resultado do Tratamento
Vasculite do Sistema Nervoso Central/terapia
Vasculite do Sistema Nervoso Central/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
8N3DW7272P (Cyclophosphamide); 9PHQ9Y1OLM (Prednisolone); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001034


  3 / 595 MEDLINE  
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[PMID]:28728872
[Au] Autor:Ciccarese G; Broccolo F; Rebora A; Parodi A; Drago F
[Ad] Endereço:DISSAL Department of Dermatology, IRCCS AOU San Martino-IST, Genoa, Italy. Electronic address: giuliaciccarese@libero.it.
[Ti] Título:Oropharyngeal lesions in pityriasis rosea.
[So] Source:J Am Acad Dermatol;77(5):833-837.e4, 2017 Nov.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence. OBJECTIVE: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms. METHODS: The records of all PR cases diagnosed in the Dermatology Clinic of Genoa University between 2003 and 2016 were retrospectively reviewed to examine sex and age of the patients, PR type, presence of enanthema, systemic symptoms, specific anti-HHV-6 and or HHV-7 serology, and HHV-6 and/or HHV-7 DNA loads. RESULTS: The oropharyngeal mucosa was carefully examined in 527 patients with PR. Painless oropharyngeal lesions were observed in 149 patients with PR (28%) and classified as erythematomacular, macular and papular, erythematovesicular, and petechial lesions. The petechial and macular and papular patterns were those most frequently observed. There was no statistically significant difference in the levels of HHV-6 and HHV-7 viremia in the plasma of patients with enanthema and those without. LIMITATIONS: Because this was a retrospective study, biopsies on mucosal lesions were not performed. CONCLUSION: Our findings showed that enanthemas are frequently associated with forms of PR different from the classic form.
[Mh] Termos MeSH primário: Doenças da Boca/epidemiologia
Doenças Faríngeas/virologia
Pitiríase Rósea/epidemiologia
Pitiríase Rósea/virologia
[Mh] Termos MeSH secundário: Adulto
Distribuição por Idade
Criança
Pré-Escolar
Estudos de Coortes
Feminino
Herpesvirus Humano 6/isolamento & purificação
Herpesvirus Humano 7/isolamento & purificação
Seres Humanos
Masculino
Meia-Idade
Doenças da Boca/fisiopatologia
Doenças da Boca/virologia
Mucosa Bucal/fisiopatologia
Mucosa Bucal/virologia
Doenças Faríngeas/epidemiologia
Doenças Faríngeas/fisiopatologia
Faringe/fisiopatologia
Faringe/virologia
Pitiríase Rósea/patologia
Prevalência
Prognóstico
Sistema de Registros
Estudos Retrospectivos
Medição de Risco
Distribuição por Sexo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE


  4 / 595 MEDLINE  
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[PMID]:28542207
[Au] Autor:Lewandowska DW; Schreiber PW; Schuurmans MM; Ruehe B; Zagordi O; Bayard C; Greiner M; Geissberger FD; Capaul R; Zbinden A; Böni J; Benden C; Mueller NJ; Trkola A; Huber M
[Ad] Endereço:Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
[Ti] Título:Metagenomic sequencing complements routine diagnostics in identifying viral pathogens in lung transplant recipients with unknown etiology of respiratory infection.
[So] Source:PLoS One;12(5):e0177340, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lung transplant patients are a vulnerable group of immunosuppressed patients that are prone to frequent respiratory infections. We studied 60 episodes of respiratory symptoms in 71 lung transplant patients. Almost half of these episodes were of unknown infectious etiology despite extensive routine diagnostic testing. METHODS: We re-analyzed respiratory samples of all episodes with undetermined etiology in order to detect potential viral pathogens missed/not accounted for in routine diagnostics. Respiratory samples were enriched for viruses by filtration and nuclease digestion, whole nucleic acids extracted and randomly amplified before high throughput metagenomic virus sequencing. Viruses were identified by a bioinformatic pipeline and confirmed and quantified using specific real-time PCR. RESULTS: In completion of routine diagnostics, we identified and confirmed a viral etiology of infection by our metagenomic approach in four patients (three Rhinovirus A, one Rhinovirus B infection) despite initial negative results in specific multiplex PCR. Notably, the majority of samples were also positive for Torque teno virus (TTV) and Human Herpesvirus 7 (HHV-7). While TTV viral loads increased with immunosuppression in both throat swabs and blood samples, HHV-7 remained at low levels throughout the observation period and was restricted to the respiratory tract. CONCLUSION: This study highlights the potential of metagenomic sequencing for virus diagnostics in cases with previously unknown etiology of infection and in complex diagnostic situations such as in immunocompromised hosts.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/virologia
Transplante de Pulmão
Metagenoma
Complicações Pós-Operatórias/virologia
Infecções por Vírus de RNA/virologia
Infecções Respiratórias/virologia
[Mh] Termos MeSH secundário: Adulto
Infecções por Vírus de DNA/diagnóstico
Feminino
Genoma Viral
Herpesvirus Humano 7/genética
Herpesvirus Humano 7/isolamento & purificação
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Masculino
Metagenômica
Meia-Idade
Infecções por Picornaviridae/virologia
Complicações Pós-Operatórias/diagnóstico
Infecções por Vírus de RNA/diagnóstico
Infecções Respiratórias/diagnóstico
Rhinovirus/genética
Rhinovirus/isolamento & purificação
Infecções por Roseolovirus/diagnóstico
Infecções por Roseolovirus/virologia
Torque teno virus/genética
Torque teno virus/isolamento & purificação
Transplantados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177340


  5 / 595 MEDLINE  
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[PMID]:28284243
[Au] Autor:Prusty BK; Gulve N; Rasa S; Murovska M; Hernandez PC; Ablashi DV
[Ad] Endereço:1​Department of Microbiology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
[Ti] Título:Possible chromosomal and germline integration of human herpesvirus 7.
[So] Source:J Gen Virol;98(2):266-274, 2017 Feb.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human herpesvirus 7 (HHV-7) is a betaherpesvirus, and is phylogenetically related to both HHV-6A and HHV-6B. The presence of telomeric repeat sequences at both ends of its genome should make it equally likely to integrate into the human telomere as HHV-6. However, numerous studies have failed to detect germline integration of HHV-7, suggesting an important difference between the HHV-6A/-6B and HHV-7 genomes. In search of possible germline integrated HHV-7, we developed a sensitive and quantitative real-time PCR assay and discovered that primers designed against some parts of the HHV-7 genome can frequently miss HHV-7 positive clinical samples even though they work efficiently in cell-culture-derived HHV-7 positive materials. Using a primer pair against the U90 ORF of HHV-7, we identified a possible case of germline integration of HHV-7 with one copy of viral genome per cell in both peripheral blood cells and hair follicles. Chromosomal integration of HHV-7 in these individuals was confirmed by fluorescence in situ hybridization analysis. Germline integration of HHV-7 was further confirmed by detection of ~2.6 copies of HHV-7 in the hair follicles of one of the parents. Our results shed light on the complex nature of the HHV-7 genome in human-derived materials in comparison to cell-culture-derived materials and show the need for stringent criteria in the selection of primers for epidemiological HHV-7 studies.
[Mh] Termos MeSH primário: Cromossomos Humanos/virologia
Células Germinativas/virologia
Herpesvirus Humano 7/genética
Herpesvirus Humano 7/fisiologia
Infecções por Roseolovirus/virologia
Telômero/virologia
Integração Viral
[Mh] Termos MeSH secundário: Adulto
Células Sanguíneas/virologia
Linhagem Celular
Feminino
Genoma Viral
Folículo Piloso/virologia
Seres Humanos
Hibridização in Situ Fluorescente
Masculino
Infecções por Roseolovirus/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000692


  6 / 595 MEDLINE  
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[PMID]:28179532
[Au] Autor:Patel SJ; Zhao G; Penna VR; Park E; Lauron EJ; Harvey IB; Beatty WL; Plougastel-Douglas B; Poursine-Laurent J; Fremont DH; Wang D; Yokoyama WM
[Ad] Endereço:Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
[Ti] Título:A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion.
[So] Source:J Virol;91(9), 2017 May 01.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the genus of the human subfamily. Infections with these viruses have been implicated in many diseases; however, it has been challenging to establish infections with roseoloviruses as direct drivers of pathology, because they are nearly ubiquitous and display species-specific tropism. Furthermore, controlled study of infection has been hampered by the lack of experimental models, and until now, a mouse roseolovirus has not been identified. Herein we describe a virus that causes severe thymic necrosis in neonatal mice, characterized by a loss of CD4 T cells. These phenotypes resemble those caused by the previously described mouse thymic virus (MTV), a putative herpesvirus that has not been molecularly characterized. By next-generation sequencing of infected tissue homogenates, we assembled a contiguous 174-kb genome sequence containing 128 unique predicted open reading frames (ORFs), many of which were most closely related to herpesvirus genes. Moreover, the structure of the virus genome and phylogenetic analysis of multiple genes strongly suggested that this virus is a betaherpesvirus more closely related to the roseoloviruses, HHV-6A, HHV-6B, and HHV-7, than to another murine betaherpesvirus, mouse cytomegalovirus (MCMV). As such, we have named this virus murine roseolovirus (MRV) because these data strongly suggest that MRV is a mouse homolog of HHV-6A, HHV-6B, and HHV-7. Herein we describe the complete genome sequence of a novel murine herpesvirus. By sequence and phylogenetic analyses, we show that it is a betaherpesvirus most closely related to the roseoloviruses, human herpesviruses 6A, 6B, and 7. These data combined with physiological similarities with human roseoloviruses collectively suggest that this virus is a murine roseolovirus (MRV), the first definitively described rodent roseolovirus, to our knowledge. Many biological and clinical ramifications of roseolovirus infection in humans have been hypothesized, but studies showing definitive causative relationships between infection and disease susceptibility are lacking. Here we show that MRV infects the thymus and causes T-cell depletion, suggesting that other roseoloviruses may have similar properties.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Herpesviridae/classificação
Herpesvirus Humano 6/genética
Herpesvirus Humano 7/genética
Depleção Linfocítica
Infecções por Roseolovirus/virologia
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Linfócitos T CD4-Positivos/citologia
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/citologia
Linfócitos T CD8-Positivos/imunologia
DNA Viral/genética
Genoma Viral/genética
Seres Humanos
Evasão da Resposta Imune/genética
Evasão da Resposta Imune/imunologia
Contagem de Linfócitos
Camundongos
Camundongos Endogâmicos BALB C
Fases de Leitura Aberta/genética
Filogenia
Análise de Sequência de DNA
Timo/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE


  7 / 595 MEDLINE  
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[PMID]:28115404
[Au] Autor:Voss V; Mattox A; Guo M
[Ad] Endereço:Saint Louis University, Saint Louis, Missouri, USA.
[Ti] Título:Concurrent pityriasis rosea and Bell's palsy.
[So] Source:BMJ Case Rep;2017, 2017 Jan 23.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pityriasis rosea is a dermatological disease with a well-documented clinical appearance, but less is known about causes and treatment. Bell's palsy is a neurological condition leading to acute idiopathic hemifacial paralysis. Recent studies indicate that human herpesvirus (HHV) 6-7 reactivation may be a contributing factor to both conditions. We report a case of the 2 concurrent diagnoses that supports a common contributing factor and suggests further awareness and research into the role HHV 6-7 may play in the aetiology of both conditions.
[Mh] Termos MeSH primário: Paralisia de Bell/complicações
Pitiríase Rósea/complicações
Infecções por Roseolovirus/complicações
[Mh] Termos MeSH secundário: Aciclovir/uso terapêutico
Antivirais/uso terapêutico
Paralisia de Bell/tratamento farmacológico
Paralisia de Bell/virologia
Criança
Feminino
Glucocorticoides/uso terapêutico
Herpesvirus Humano 6
Herpesvirus Humano 7
Seres Humanos
Pitiríase Rósea/tratamento farmacológico
Pitiríase Rósea/virologia
Prednisona/uso terapêutico
Infecções por Roseolovirus/tratamento farmacológico
Infecções por Roseolovirus/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Glucocorticoids); VB0R961HZT (Prednisone); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:28081700
[Au] Autor:Caselli E; D'Accolti M; Soffritti I; Zatelli MC; Rossi R; Degli Uberti E; Di Luca D
[Ad] Endereço:Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, via L. Borsari 46, 44121, Ferrara, Italy. elisabetta.caselli@unife.it.
[Ti] Título:HHV-6A in vitro infection of thyrocytes and T cells alters the expression of miRNA associated to autoimmune thyroiditis.
[So] Source:Virol J;14(1):3, 2017 Jan 11.
[Is] ISSN:1743-422X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Human herpesviruses have been hypothesized as environmental triggers in the development of autoimmune thyroid diseases (AITD), and in particular active human herpesvirus 6A (HHV-6A) infection was detected in thyrocytes of Hashimoto's thyroiditis (HT) patients, who also show specific anti-viral immune responses. On the other hand, AITD patients display modulation of specific miRNAs in thyroid tissue and blood. We wanted to ascertain whether HHV-6A infection might be correlated to the miRNA dysregulation observed in AITD. METHODS: Human thyroid and T-cell lines were infected in vitro with HHV-6A,-6B or -7, and analysed for miRNAs expression, either by microarray or by specific RT-PCR assays detecting miRNAs associated with AITD in vivo. RESULTS: HHV-6A infection, but not -6B or -7 infections, induced a decrease in miR-155_2 expression and an increase in miR-1238 expression in thyrocytes, as well as an increase in the expression levels of several autoimmunity-associated miRNAs in T lymphocytes, including miR-16_1, miR34a, miR-130a, miR-143_1, miR-202, miR-301b, miR-302c, miR-449b, miR-451_1, and miR-1238_2. CONCLUSIONS: HHV-6A infection modulates miRNAs expression in the cell types involved in the development of AITD. Notably, our in vitro findings correlate with what observed in AITD patients, further supporting the association between HHV-6A infection and AITD development. Moreover, these effects are 6A-specific, emphasizing the differences between the two HHV-6 virus species, and suggesting diverse virus mechanisms of action and therapeutic approaches.
[Mh] Termos MeSH primário: Herpesvirus Humano 6/crescimento & desenvolvimento
MicroRNAs/análise
Linfócitos T/virologia
Células Epiteliais da Tireóide/virologia
Tireoidite Autoimune/patologia
[Mh] Termos MeSH secundário: Perfilação da Expressão Gênica
Herpesvirus Humano 7/crescimento & desenvolvimento
Seres Humanos
Análise em Microsséries
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1186/s12985-016-0672-6


  9 / 595 MEDLINE  
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[PMID]:27977551
[Au] Autor:Rangel MA; Moreira D; Vila Real M; Santos F
[Ad] Endereço:From the *Paediatrics Department, and †Neuroscience Unit for Children and Adolescents, Paediatrics Department, Centro Hospitalar de Vila Nova de Gaia e Espinho, Vila Nova de Gaia, Portugal.
[Ti] Título:Meningoradiculopathy Associated with Human Herpesvirus 7-A Virus with Potential to Cause Severe Neurologic Disease with Sequelae.
[So] Source:Pediatr Infect Dis J;36(4):427-429, 2017 Apr.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We present a case report of a meningoradiculopathy associated with human herpesvirus 7, with long-term motor neurologic sequelae. It is important to consider human herpesvirus 7 as a potential pathogen of severe neurologic disease and sequelae in immunocompetent children, especially in older patients presenting neurologic signs.
[Mh] Termos MeSH primário: Viroses do Sistema Nervoso Central
Herpesvirus Humano 7
Infecções por Roseolovirus
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001459


  10 / 595 MEDLINE  
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[PMID]:27826611
[Au] Autor:Brazzelli V; Giorgini C; Barruscotti S; Croci GA; Borroni G
[Ad] Endereço:Institute of Dermatology, Department of Clinical-Surgical, Diagnostic and Pediatric Science, IRCCS Fondation Policlinico San Matteo, University of Pavia, IT-27100 Pavia, Italy. v.brazzelli@smatteo.pv.it, vbrazzelli@libero.it.
[Ti] Título:Human Herpesvirus-7 Papular Rash in a Healthy Adult Patient.
[So] Source:Acta Derm Venereol;97(4):537-538, 2017 04 06.
[Is] ISSN:1651-2057
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Mh] Termos MeSH primário: DNA Viral/genética
Exantema/virologia
Herpesvirus Humano 7/genética
Infecções por Roseolovirus/virologia
Dermatopatias Virais/virologia
[Mh] Termos MeSH secundário: Biópsia
DNA Viral/sangue
Exantema/diagnóstico
Seres Humanos
Masculino
Meia-Idade
Prurido/virologia
Infecções por Roseolovirus/diagnóstico
Dermatopatias Virais/diagnóstico
Carga Viral
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE
[do] DOI:10.2340/00015555-2567



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