Base de dados : MEDLINE
Pesquisa : B04.280.382.530 [Categoria DeCS]
Referências encontradas : 16 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2 ir para página        

  1 / 16 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28425428
[Au] Autor:Ourth DD; Marecaux E; Raghu D; Peterson BC
[Ad] Endereço:Department of Biological Sciences, The University of Memphis, Memphis, TN 38152, USA.
[Ti] Título:Innate immune response of channel catfish Ictalurus punctatus mannose-binding lectin to channel catfish virus (CCV).
[So] Source:Dis Aquat Organ;124(2):159-163, 2017 04 20.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The channel catfish virus (CCV) is a pathogenic herpesvirus that infects channel catfish Ictalurus punctatus in pond aquaculture in the southeastern USA. Mannose-binding lectin (MBL), an innate immune protein, could play an important role in the innate response of channel catfish by binding to CCV. Cell cultures of CCV were grown in channel catfish ovary cells (CCOC). A dot-immunoblot enzyme-linked immunosorbent assay was done to determine the binding ability of 5 mo old channel catfish serum MBL (26.2 µg ml-1) to CCOC infected with CCV. Two separate nitrocellulose membrane blotting techniques were done using uninfected and infected CCOC. The uninfected CCOC decreased by 29.3 and 33.4% in their binding of channel catfish MBL when compared with infected CCOC using the 2 membrane procedures. The combined average binding ability of channel catfish MBL towards infected CCOC was therefore 31.4% greater when comparing the infected and uninfected CCOC. Normalization equation values of MBL for the 5 mo old catfish were compared for the 2 membrane binding procedures. The 2 normalization values were very close (142 and 150) in binding ability of MBL to the infected CCOC. The 5 mo catfish serum had twice the concentration of MBL (26.2 µg ml-1) compared to 7 mo catfish serum (13.2 µg ml-1), and the binding percentage of 5 mo serum was 2.4 times greater in infected than in uninfected cells. This demonstrates that the binding of channel catfish serum MBL to CCV is concentration dependent and is related to serum concentrations of MBL.
[Mh] Termos MeSH primário: Infecções por Herpesviridae/veterinária
Ictaluridae/sangue
Ictalurivirus/imunologia
Imunidade Inata/fisiologia
Lectina de Ligação a Manose/fisiologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Ensaio de Imunoadsorção Enzimática
Feminino
Infecções por Herpesviridae/virologia
Immunoblotting
Lectina de Ligação a Manose/sangue
Ovário/citologia
Ligação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mannose-Binding Lectin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.3354/dao03109


  2 / 16 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26856701
[Au] Autor:Taylor EB; Moulana M; Stuge TB; Quiniou SM; Bengten E; Wilson M
[Ad] Endereço:Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216;
[Ti] Título:A Leukocyte Immune-Type Receptor Subset Is a Marker of Antiviral Cytotoxic Cells in Channel Catfish, Ictalurus punctatus.
[So] Source:J Immunol;196(6):2677-89, 2016 Mar 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Channel catfish, Ictalurus punctatus, leukocyte immune type receptors (LITRs) represent a multigene family that encodes Ig superfamily proteins that mediate activating or inhibitory signaling. In this study, we demonstrate the use of mAb CC41 to monitor viral cytotoxic responses in catfish and determine that CC41 binds to a subset of LITRs on the surface of catfish clonal CTLs. Homozygous gynogenetic catfish were immunized with channel catfish virus (CCV)-infected MHC-matched clonal T cells (G14D-CCV), and PBL were collected at various times after immunization for flow cytometric analyses. The percentage of CC41(+) cells was significantly increased 5 d after primary immunization with G14D-CCV and at 3 d after a booster immunization as compared with control fish only injected with G14D. Moreover, CC41(+) cells magnetically isolated from the PBL specifically killed CCV-infected targets as measured by (51)Cr release assays and expressed messages for CD3γδ, perforin, and at least one of the CD4-like receptors as analyzed by RNA flow cytometry. When MLC effector cells derived from a G14D-CCV-immunized fish were preincubated with CC41 mAb, killing of G14D-CCV targets was reduced by ∼40%, suggesting that at least some LITRs have a role in target cell recognition and/or cytotoxicity. The availability of a LITR-specific mAb has allowed, to our knowledge for the first time, functional characterization of LITRs in an autologous system. In addition, the identification of an LITR subset as a cytotoxic cell marker will allow for more effective monitoring of catfish immune responses to pathogens.
[Mh] Termos MeSH primário: Doenças dos Peixes/imunologia
Infecções por Herpesviridae/imunologia
Ictaluridae
Ictalurivirus/imunologia
Leucócitos/imunologia
Receptores Imunológicos/metabolismo
Linfócitos T Citotóxicos/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais/metabolismo
Proliferação Celular
Células Clonais
Citotoxicidade Imunológica
Imunização
Leucócitos/virologia
Receptores de Antígenos de Linfócitos T gama-delta/metabolismo
Receptores Imunológicos/imunologia
Transdução de Sinais
Linfócitos T Citotóxicos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Receptors, Antigen, T-Cell, gamma-delta); 0 (Receptors, Immunologic)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160305
[Lr] Data última revisão:
160305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160210
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1502166


  3 / 16 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25594335
[Au] Autor:Liu GX; Lin L; Wang M; Liu XQ
[Ad] Endereço:Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan, China.
[Ti] Título:Development and evaluation of a loop-mediated isothermal amplification assay for the detection of channel catfish virus.
[So] Source:J Fish Dis;38(12):1073-6, 2015 Dec.
[Is] ISSN:1365-2761
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças dos Peixes/virologia
Infecções por Herpesviridae/veterinária
Ictaluridae/virologia
Ictalurivirus
Técnicas de Amplificação de Ácido Nucleico/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças dos Peixes/diagnóstico
Infecções por Herpesviridae/diagnóstico
Infecções por Herpesviridae/virologia
Ictalurivirus/genética
Técnicas de Amplificação de Ácido Nucleico/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150117
[St] Status:MEDLINE
[do] DOI:10.1111/jfd.12335


  4 / 16 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:24117659
[Au] Autor:Siti-Zahrah A; Zamri-Saad M; Firdaus-Nawi M; Hazreen-Nita MK; Nur-Nazifah M
[Ad] Endereço:National Fish Health Research Centre (NaFisH), Fisheries Research Institute (FRI), Penang, Malaysia.
[Ti] Título:Detection of channel catfish virus in cage-cultured Pangasius hypophthalmus (Sauvage, 1878) in Malaysia.
[So] Source:J Fish Dis;37(11):981-3, 2014 Nov.
[Is] ISSN:1365-2761
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Peixes-Gato/virologia
Doenças dos Peixes/epidemiologia
Infecções por Herpesviridae/veterinária
Ictalurivirus/fisiologia
[Mh] Termos MeSH secundário: Animais
Doenças dos Peixes/patologia
Doenças dos Peixes/virologia
Pesqueiros
Infecções por Herpesviridae/epidemiologia
Infecções por Herpesviridae/patologia
Infecções por Herpesviridae/virologia
Ictalurivirus/isolamento & purificação
Rim/patologia
Rim/virologia
Malásia/epidemiologia
Prevalência
Baço/patologia
Baço/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1504
[Cu] Atualização por classe:141009
[Lr] Data última revisão:
141009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131015
[St] Status:MEDLINE
[do] DOI:10.1111/jfd.12185


  5 / 16 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22356443
[Au] Autor:Liu Y; Yuan J; Wang W; Chen X; Tang R; Wang M; Li L
[Ad] Endereço:College of Fisheries, Huazhong Agriculture University, Wuhan 430070, People's Republic of China.
[Ti] Título:Identification of envelope protein orf10 of channel catfish herpesvirus.
[So] Source:Can J Microbiol;58(3):271-7, 2012 Mar.
[Is] ISSN:1480-3275
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Channel catfish virus (CCV) is a viral pathogen of fry and fingerling channel catfish and can cause significant commercial loss. Previous studies have shown that the CCV virion contains at least 25 predicted structural proteins, including viral protein 10, which is encoded by the orf10 gene of the CCV. In this paper, the orf10 gene was expressed in Escherichia coli and used to produce a specific antibody. Western blot analysis confirmed that open reading frame 10 is an envelope protein. A viral neutralization assay demonstrated that open reading frame 10 antiserum was able to inhibit CCV infection of channel catfish ovary cells, suggesting that viral protein 10 is likely to play an important role in the CCV infection of channel catfish ovary cells.
[Mh] Termos MeSH primário: Produtos do Gene env/genética
Ictalurivirus/genética
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Escherichia coli/genética
Produtos do Gene env/imunologia
Produtos do Gene env/metabolismo
Ictalurivirus/imunologia
Ictalurivirus/metabolismo
Soros Imunes/imunologia
Microscopia Imunoeletrônica
Testes de Neutralização
Fases de Leitura Aberta/genética
Vírion/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gene Products, env); 0 (Immune Sera)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:120307
[Lr] Data última revisão:
120307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120224
[St] Status:MEDLINE
[do] DOI:10.1139/w11-128


  6 / 16 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22149282
[Au] Autor:Wu B; Zhu B; Luo Y; Wang M; Lu Y; Wang W; Cao S; Huang F; Liu X
[Ad] Endereço:College of Fisheries, Huazhong Agricultural University, Wuhan, China.
[Ti] Título:Generation and characterization of monoclonal antibodies against channel catfish virus.
[So] Source:Hybridoma (Larchmt);30(6):555-8, 2011 Dec.
[Is] ISSN:1557-8348
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Three monoclonal antibodies (MAbs) against channel catfish virus (CCV) were generated from mice immunized with purified CCV. Western blot analysis revealed that the MAb 3G12 reacted with three CCV proteins of 94 kDa, 130 kDa, and 170 kDa; the MAb 4C4 reacted with two CCV proteins of 130 kDa and 170 kDa; and the MAb 4D4 reacted with two CCV proteins of 94 kDa and 98 kDa. Indirect immunofluorescence assay showed intense fluorescence in the CCV-infected channel catfish ovary (CCO) cells in areas corresponding to the location of granular structures. In addition, the three MAbs could completely neutralize CCV at a dilution of 1:500. This study demonstrated that these MAbs could recognize CCV specifically and will be useful in the development of diagnostic methods for the detection of fish CCV infection.
[Mh] Termos MeSH primário: Anticorpos Monoclonais Murinos/imunologia
Especificidade de Anticorpos
Infecções por Herpesviridae/veterinária
Ictaluridae/virologia
Ictalurivirus/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais Murinos/genética
Anticorpos Neutralizantes
Reações Antígeno-Anticorpo
Western Blotting
Linhagem Celular
Feminino
Fluorescência
Técnica Indireta de Fluorescência para Anticorpo
Infecções por Herpesviridae/imunologia
Infecções por Herpesviridae/virologia
Hibridomas/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Testes de Neutralização
Ovário/imunologia
Ovário/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Monoclonal, Murine-Derived); 0 (Antibodies, Neutralizing)
[Em] Mês de entrada:1204
[Cu] Atualização por classe:111214
[Lr] Data última revisão:
111214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111214
[St] Status:MEDLINE
[do] DOI:10.1089/hyb.2011.0063


  7 / 16 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:21935624
[Au] Autor:Doszpoly A; Somogyi V; LaPatra SE; Benko M
[Ad] Endereço:Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary. adoszpoly@vmri.hu
[Ti] Título:Partial genome characterization of acipenserid herpesvirus 2: taxonomical proposal for the demarcation of three subfamilies in Alloherpesviridae.
[So] Source:Arch Virol;156(12):2291-6, 2011 Dec.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Sequencing of approximately one half of the genome of acipenserid herpesvirus 2 (AciHV-2), which is a member of the genus Ictalurivirus in the family Alloherpesviridae, revealed that the gene organization is very similar to that of ictalurid herpesvirus 1 (IcHV-1), the founder member of the genus. The sequenced region encodes the AciHV-2 homologues of IcHV-1 ORF24 to ORF69. It contains 46 predicted protein-coding regions, including 12 that seem to have a homologue in every alloherpesvirus genome sequenced to date. Phylogenetic tree reconstruction, based on the concatenated sequence of these conserved genes, implied that the family Alloherpesviridae is composed of three major clades and could be subdivided into three subfamilies.
[Mh] Termos MeSH primário: Genoma Viral
Herpesviridae/classificação
Herpesviridae/genética
Ictalurivirus/classificação
Ictalurivirus/genética
[Mh] Termos MeSH secundário: Anfíbios/virologia
Animais
Sequência de Bases
Classificação
Primers do DNA/genética
DNA Viral/genética
Peixes/virologia
Dados de Sequência Molecular
Filogenia
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA Primers); 0 (DNA, Viral)
[Em] Mês de entrada:1202
[Cu] Atualização por classe:111201
[Lr] Data última revisão:
111201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110922
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-011-1108-7


  8 / 16 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:21932530
[Au] Autor:Arnizaut AB; Hanson LA
[Ad] Endereço:Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi 39762, USA.
[Ti] Título:Antibody response of channel catfish after channel catfish virus infection and following dexamethasone treatment.
[So] Source:Dis Aquat Organ;95(3):189-201, 2011 Jul 12.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Channel catfish virus (CCV, Ictalurid herpesvirus 1) and CCV disease have been extensively studied. Yet, little is known about CCV-host interaction after resolution of the primary infection. In order to determine potential recrudescence of CCV from latency, we established latency by exposing channel catfish juveniles with CCV or a thymidine kinase-negative recombinant (CCVlacZ) at a dose that caused less than 20% mortality. Then, we evaluated antibody response by serially sampling the same fish at 0 (pre-infection), 30, 60 and 90 d post challenge (DPC). We then attempted to induce viral recrudescence by intramuscular administration of dexamethasone and sampled the fish at 2, 4, 7, or 10 d post treatment. Recrudescence was evaluated by leukocyte co-cultivation and cell culture of tissue homogenates but no virus was detected. Western blot data demonstrated the highest number of seropositive fish by 30 DPC and a secondary antibody induction after dexamethasone treatment. The antigen specificity of the secondary response corresponded to viral proteins with molecular masses similar to those recognized by the same fish by 30 DPC. The recognized proteins were predominantly large, ranging from approximately 90 to >200 kDa. Expression analysis of selected virus genes at 90 DPC and following dexamethasone treatment demonstrated occasional immediate-early virus gene expression in peripheral blood leukocytes. Early and late gene expression was rarely detected. The combined data suggest restricted re-activation of CCV in our experimental system. Primary and secondary responses and virus gene expression were demonstrated in CCVlacZ-exposed fish but were less frequent than in CCV-exposed fish.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Dexametasona/toxicidade
Doenças dos Peixes/imunologia
Infecções por Herpesviridae/veterinária
Ictaluridae
Ictalurivirus
[Mh] Termos MeSH secundário: Animais
Doenças dos Peixes/virologia
Regulação Viral da Expressão Gênica
Infecções por Herpesviridae/imunologia
Infecções por Herpesviridae/virologia
Interações Hospedeiro-Patógeno
Temperatura Alta/efeitos adversos
Imunossupressores/toxicidade
Recidiva
Latência Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Immunosuppressive Agents); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1110
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110922
[St] Status:MEDLINE
[do] DOI:10.3354/dao02348


  9 / 16 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:21228534
[Au] Autor:Doszpoly A; Benko M; Bovo G; Lapatra SE; Harrach B
[Ad] Endereço:Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest.
[Ti] Título:Comparative analysis of a conserved gene block from the genome of the members of the genus ictalurivirus.
[So] Source:Intervirology;54(5):282-9, 2011.
[Is] ISSN:1423-0100
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Partial genome sequences were determined and subjected to comparative analyses from two fish herpesviruses (HVs). Acipenserid (Aci) HV-2, originating from the white sturgeon (Acipenser transmontanus), and ictalurid (Ic) HV-2, isolated from the black bullhead (Ameiurus melas), are recently approved species of the genus Ictalurivirus of the family Alloherpesviridae. METHODS: An almost 8,000-base-pair fragment, spanning between the genes of the DNA polymerase and the ATPase subunit of the terminase, was sequenced from each virus. RESULTS: The size, position and orientation of 2 partial and 3 full open reading frames, contained in the studied genome fragment, proved to be similar to their counterparts in IcHV-1, the type species of the genus Ictalurivirus. Thus, a well-conserved genus-specific gene block was identified. In the members of two other genera (Cyprinivirus and Batrachovirus) of the family Alloherpesviridae, no such gene block could be found; the location and orientation of the homologous genes showed significant divergence. CONCLUSION: The results of phylogenetic calculations were in good agreement with the genome arrangements inasmuch as AciHV-2, IcHV-1 and -2 are monophyletic and separated from the lineages of the other two genera. The new sequence enabled the inclusion of a hitherto unassigned HV, that of the Australian pilchard, into a phylogenetic calculation.
[Mh] Termos MeSH primário: Sequência Conservada
Genes Virais
Genoma Viral
Ictalurivirus/genética
[Mh] Termos MeSH secundário: Animais
Análise por Conglomerados
DNA Viral/química
DNA Viral/genética
DNA Polimerase Dirigida por DNA/genética
Endodesoxirribonucleases/genética
Peixes/virologia
Ictalurivirus/isolamento & purificação
Dados de Sequência Molecular
Filogenia
Análise de Sequência de DNA
Homologia de Sequência
Proteínas Virais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Viral); 0 (Viral Proteins); EC 2.7.7.7 (DNA-Directed DNA Polymerase); EC 3.1.- (Endodeoxyribonucleases); EC 3.1.- (terminase)
[Em] Mês de entrada:1112
[Cu] Atualização por classe:110823
[Lr] Data última revisão:
110823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110114
[St] Status:MEDLINE
[do] DOI:10.1159/000319430


  10 / 16 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:20691099
[Au] Autor:Yasuhara-Bell J; Yang Y; Barlow R; Trapido-Rosenthal H; Lu Y
[Ad] Endereço:Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A, Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
[Ti] Título:In vitro evaluation of marine-microorganism extracts for anti-viral activity.
[So] Source:Virol J;7:182, 2010 Aug 07.
[Is] ISSN:1743-422X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Viral-induced infectious diseases represent a major health threat and their control remains an unachieved goal, due in part to the limited availability of effective anti-viral drugs and measures. The use of natural products in drug manufacturing is an ancient and well-established practice. Marine organisms are known producers of pharmacological and anti-viral agents. In this study, a total of 20 extracts from marine microorganisms were evaluated for their antiviral activity. These extracts were tested against two mammalian viruses, herpes simplex virus (HSV-1) and vesicular stomatitis virus (VSV), using Vero cells as the cell culture system, and two marine virus counterparts, channel catfish virus (CCV) and snakehead rhabdovirus (SHRV), in their respective cell cultures (CCO and EPC). Evaluation of these extracts demonstrated that some possess antiviral potential. In sum, extracts 162M(4), 258M(1), 298M(4), 313(2), 331M(2), 367M(1) and 397(1) appear to be effective broad-spectrum antivirals with potential uses as prophylactic agents to prevent infection, as evident by their highly inhibitive effects against both virus types. Extract 313(2) shows the most potential in that it showed significantly high inhibition across all tested viruses. The samples tested in this study were crude extracts; therefore the development of antiviral application of the few potential extracts is dependent on future studies focused on the isolation of the active elements contained in these extracts.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Bactérias/química
Diatomáceas/química
Água do Mar/microbiologia
Vírus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antivirais/isolamento & purificação
Bactérias/isolamento & purificação
Linhagem Celular
Diatomáceas/isolamento & purificação
Herpesvirus Humano 1/efeitos dos fármacos
Seres Humanos
Ictalurivirus/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Novirhabdovirus/efeitos dos fármacos
Vesiculovirus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Antiviral Agents)
[Em] Mês de entrada:1012
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100810
[St] Status:MEDLINE
[do] DOI:10.1186/1743-422X-7-182



página 1 de 2 ir para página        
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde