Base de dados : MEDLINE
Pesquisa : B04.280.410.700 [Categoria DeCS]
Referências encontradas : 318 [refinar]
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[PMID]:28931029
[Au] Autor:Price SJ; Wadia A; Wright ON; Leung WTM; Cunningham AA; Lawson B
[Ad] Endereço:UCL Genetics Institute, Gower Street, London, United Kingdom.
[Ti] Título:Screening of a long-term sample set reveals two Ranavirus lineages in British herpetofauna.
[So] Source:PLoS One;12(9):e0184768, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reports of severe disease outbreaks in amphibian communities in mainland Europe due to strains of the common midwife toad virus (CMTV)-like clade of Ranavirus are increasing and have created concern due to their considerable population impacts. In Great Britain, viruses in another clade of Ranavirus-frog virus 3 (FV3)-like-have caused marked declines of common frog (Rana temporaria) populations following likely recent virus introductions. The British public has been reporting mortality incidents to a citizen science project since 1992, with carcasses submitted for post-mortem examination, resulting in a long-term tissue archive spanning 25 years. We screened this archive for ranavirus (458 individuals from 228 incidents) using molecular methods and undertook preliminary genotyping of the ranaviruses detected. In total, ranavirus was detected in 90 individuals from 41 incidents focused in the north and south of England. The majority of detections involved common frogs (90%) but also another anuran, a caudate and a reptile. Most incidents were associated with FV3-like viruses but two, separated by 300 km and 16 years, involved CMTV-like viruses. These British CMTV-like viruses were more closely related to ranaviruses from mainland Europe than to each other and were estimated to have diverged at least 458 years ago. This evidence of a CMTV-like virus in Great Britain in 1995 represents the earliest confirmed case of a CMTV associated with amphibians and raises important questions about the history of ranavirus in Great Britain and the epidemiology of CMTV-like viruses. Despite biases present in the opportunistic sample used, this study also demonstrates the role of citizen science projects in generating resources for research and the value of maintaining long-term wildlife tissue archives.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/diagnóstico
Infecções por Vírus de DNA/veterinária
Ranavirus/genética
Ranavirus/isolamento & purificação
Répteis/virologia
[Mh] Termos MeSH secundário: Animais
Infecções por Vírus de DNA/epidemiologia
Infecções por Vírus de DNA/virologia
DNA Viral/análise
Filogenia
Ranavirus/classificação
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184768


  2 / 318 MEDLINE  
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[PMID]:28919326
[Au] Autor:Huynh TP; Jancovich JK; Tripuraneni L; Heck MC; Langland JO; Jacobs BL
[Ad] Endereço:School of Life Sciences, and The Biodesign Institute, Center for Infectious Diseases and Vaccinology Arizona State University, Tempe, AZ 85287-5001, USA.
[Ti] Título:Characterization of a PKR inhibitor from the pathogenic ranavirus, Ambystoma tigrinum virus, using a heterologous vaccinia virus system.
[So] Source:Virology;511:290-299, 2017 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ambystoma tigrinum virus (ATV) (family Iridoviridae, genus Ranavirus) was isolated from diseased tiger salamanders (Ambystoma tigrinum stebbinsi) from the San Rafael Valley in southern Arizona, USA in 1996. Genomic sequencing of ATV, as well as other members of the genus, identified an open reading frame that has homology to the eukaryotic translation initiation factor, eIF2α (ATV eIF2α homologue, vIF2αH). Therefore, we asked if the ATV vIF2αH could also inhibit PKR. To test this hypothesis, the ATV vIF2αH was cloned into vaccinia virus (VACV) in place of the well-characterized VACV PKR inhibitor, E3L. Recombinant VACV expressing ATV vIF2αH partially rescued deletion of the VACV E3L gene. Rescue coincided with rapid degradation of PKR in infected cells. These data suggest that the salamander virus, ATV, contains a novel gene that may counteract host defenses, and this gene product may be involved in the presentation of disease caused by this environmentally important pathogen.
[Mh] Termos MeSH primário: Inibidores de Proteínas Quinases/metabolismo
Ranavirus/patogenicidade
Proteínas Recombinantes/metabolismo
Proteínas Virais/metabolismo
Fatores de Virulência/metabolismo
eIF-2 Quinase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Ambystoma/virologia
Animais
Arizona
Expressão Gênica
Vetores Genéticos
Interações Hospedeiro-Patógeno
Evasão da Resposta Imune
Ranavirus/genética
Proteínas Recombinantes/genética
Vírus Vaccinia/genética
Proteínas Virais/genética
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protein Kinase Inhibitors); 0 (Recombinant Proteins); 0 (Viral Proteins); 0 (Virulence Factors); EC 2.7.11.1 (eIF-2 Kinase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


  3 / 318 MEDLINE  
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[PMID]:28860047
[Au] Autor:Price SJ; Ariel E; Maclaine A; Rosa GM; Gray MJ; Brunner JL; Garner TWJ
[Ad] Endereço:UCL Genetics Institute, Gower Street, London WC1E 6BT, UK; Institute of Zoology, Zoological Society of London, Regent's Park, NW1 4RY London, UK.
[Ti] Título:From fish to frogs and beyond: Impact and host range of emergent ranaviruses.
[So] Source:Virology;511:272-279, 2017 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ranaviruses are pathogens of ectothermic vertebrates, including amphibians. We reviewed patterns of host range and virulence of ranaviruses in the context of virus genotype and postulate that patterns reflect significant variation in the historical and current host range of three groups of Ranavirus: FV3-like, CMTV-like and ATV-like ranaviruses. Our synthesis supports previous hypotheses about host range and jumps: FV3s are amphibian specialists, while ATVs are predominantly fish specialists that switched once to caudate amphibians. The most recent common ancestor of CMTV-like ranaviruses and FV3-like forms appears to have infected amphibians but CMTV-like ranaviruses may circulate in both amphibian and fish communities independently. While these hypotheses are speculative, we hope that ongoing efforts to describe ranavirus genetics, increased surveillance of host species and targeted experimental assays of susceptibility to infection and/or disease will facilitate better tests of the importance of hypothetical evolutionary drivers of ranavirus virulence and host range.
[Mh] Termos MeSH primário: Anfíbios/virologia
Peixes/virologia
Especificidade de Hospedeiro
Ranavirus/isolamento & purificação
Ranavirus/fisiologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Ranavirus/patogenicidade
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE


  4 / 318 MEDLINE  
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[PMID]:28818331
[Au] Autor:Hick PM; Subramaniam K; Thompson PM; Waltzek TB; Becker JA; Whittington RJ
[Ad] Endereço:OIE Reference Laboratory for Epizootic Haematopoietic Necrosis Virus and Ranavirus Infection of Amphibians, Sydney School of Veterinary Science and School of Life and Environmental Sciences, The University Sydney, Werombi Road, Camden 2570, NSW, Australia. Electronic address: paul.hick@sydney.edu.au
[Ti] Título:Molecular epidemiology of Epizootic haematopoietic necrosis virus (EHNV).
[So] Source:Virology;511:320-329, 2017 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Low genetic diversity of Epizootic haematopoietic necrosis virus (EHNV) was determined for the complete genome of 16 isolates spanning the natural range of hosts, geography and time since the first outbreaks of disease. Genomes ranged from 125,591-127,487 nucleotides with 97.47% pairwise identity and 106-109 genes. All isolates shared 101 core genes with 121 potential genes predicted within the pan-genome of this collection. There was high conservation within 90,181 nucleotides of the core genes with isolates separated by average genetic distance of 3.43 × 10 substitutions per site. Evolutionary analysis of the core genome strongly supported historical epidemiological evidence of iatrogenic spread of EHNV to naïve hosts and establishment of endemic status in discrete ecological niches. There was no evidence of structural genome reorganization, however, the complement of non-core genes and variation in repeat elements enabled fine scale molecular epidemiological investigation of this unpredictable pathogen of fish.
[Mh] Termos MeSH primário: Surtos de Doenças
Doenças dos Peixes/epidemiologia
Doenças dos Peixes/virologia
Variação Genética
Epidemiologia Molecular
Ranavirus/classificação
Ranavirus/genética
[Mh] Termos MeSH secundário: Animais
Infecções por Vírus de DNA/veterinária
Infecções por Vírus de DNA/virologia
Doenças Endêmicas
Peixes
Genes Virais
Genoma Viral
Doença Iatrogênica/epidemiologia
Doença Iatrogênica/veterinária
Ranavirus/isolamento & purificação
Análise de Sequência de DNA
Homologia de Sequência
Sintenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE


  5 / 318 MEDLINE  
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[PMID]:28803676
[Au] Autor:Claytor SC; Subramaniam K; Landrau-Giovannetti N; Chinchar VG; Gray MJ; Miller DL; Mavian C; Salemi M; Wisely S; Waltzek TB
[Ad] Endereço:Department of Wildlife Ecology and Conservation, University of Florida, Gainesville, FL, USA.
[Ti] Título:Ranavirus phylogenomics: Signatures of recombination and inversions among bullfrog ranaculture isolates.
[So] Source:Virology;511:330-343, 2017 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ranaviruses are emerging pathogens of fish, amphibians, and reptiles that threaten aquatic animal industries and wildlife worldwide. Our objective was to genetically characterize ranaviruses isolated during separate bullfrog Lithobates catesbeianus die-offs that occurred eight years apart on the same North American farm. The earlier outbreak was due to a highly pathogenic strain of common midwife toad virus (CMTV) previously known only from Europe and China. The later outbreak was due to a chimeric ranavirus that displayed a novel genome arrangement and a DNA backbone typical for Frog virus 3 (FV3) strains except for interspersed fragments acquired through recombination with the CMTV isolated earlier. Both bullfrog ranaviruses are more pathogenic than wild-type FV3 suggesting recombination may have resulted in the increased pathogenicity observed in the ranavirus isolated in the later outbreak. Our study underscores the role international trade in farmed bullfrogs may have played in the global dissemination of highly pathogenic ranaviruses.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/veterinária
Variação Genética
Ranavirus/classificação
Ranavirus/genética
Recombinação Genética
Inversão de Sequência
[Mh] Termos MeSH secundário: Animais
Infecções por Vírus de DNA/virologia
DNA Viral/química
DNA Viral/genética
América do Norte
Rana catesbeiana/virologia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE


  6 / 318 MEDLINE  
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[PMID]:28648249
[Au] Autor:Chinchar VG; Waltzek TB; Subramaniam K
[Ad] Endereço:University of Mississippi Medical Center, Jackson, MS 39216, USA. Electronic address: vchinchar@umc.edu.
[Ti] Título:Ranaviruses and other members of the family Iridoviridae: Their place in the virosphere.
[So] Source:Virology;511:259-271, 2017 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Members of the family Iridoviridae, collectively referred to as iridovirids, are large, double-stranded DNA-containing viruses that infect invertebrates and cold-blooded (ectothermic) vertebrates. Infections in the former often lead to massive levels of virus replication resulting in iridescence of the infected animal and ultimately death. Among the latter, infections target a variety of organs and are capable of causing high levels of morbidity and mortality among commercially and ecologically important fish and amphibian species. The viral replication strategy has been elucidated primarily through the study of frog virus 3 (FV3) with additional input from other iridovirids of ecological or commercial importance. Replication occurs within both nuclear and cytoplasmic compartments and involves synthesis of genome length and concatemeric DNA, extensive methylation of the viral genome (among vertebrate viruses only), coordinate expression of three classes of viral gene products, and formation of icosahedral virions within cytoplasmic viral assembly sites. Phylogenetic analyses delineate five genera within the family and suggest that members of the families Iridoviridae, Ascoviridae, and Marseilleviridae compromise a monophyletic lineage in which ascoviruses are most closely related to invertebrate iridoviruses.
[Mh] Termos MeSH primário: Interações Hospedeiro-Patógeno
Filogenia
Ranavirus/genética
Ranavirus/fisiologia
Replicação Viral
[Mh] Termos MeSH secundário: Anfíbios/virologia
Animais
Peixes/virologia
Invertebrados/virologia
Ranavirus/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


  7 / 318 MEDLINE  
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[PMID]:28625407
[Au] Autor:Jacques R; Edholm ES; Jazz S; Odalys TL; Francisco JA
[Ad] Endereço:Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, United States. Electronic address: Jacques_Robert@urmc.rochester.edu.
[Ti] Título:Xenopus-FV3 host-pathogen interactions and immune evasion.
[So] Source:Virology;511:309-319, 2017 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We first review fundamental insights into anti-ranavirus immunity learned with the Xenopus laevis/ranavirus FV3 model that are generally applicable to ectothermic vertebrates. We then further investigate FV3 genes involved in immune evasion. Focusing on FV3 knockout (KO) mutants defective for a putative viral caspase activation and recruitment domain-containing (CARD)-like protein (Δ64R-FV3), a ß-hydroxysteroid dehydrogenase homolog (Δ52L-FV3), and an immediate-early18kDa protein (FV3-Δ18K), we assessed the involvement of these viral genes in replication, dissemination and interaction with peritoneal macrophages in tadpole and adult frogs. Our results substantiate the role of 64R and 52L as critical immune evasion genes, promoting persistence and dissemination in the host by counteracting type III IFN in tadpoles and type I IFN in adult frogs. Comparably, the substantial accumulation of genome copy numbers and exacerbation of type I and III IFN gene expression responses but deficient release of infectious virus suggests that 18K is a viral regulatory gene.
[Mh] Termos MeSH primário: Interações Hospedeiro-Patógeno
Evasão da Resposta Imune
Ranavirus/patogenicidade
Xenopus laevis/imunologia
Xenopus laevis/virologia
[Mh] Termos MeSH secundário: Animais
Técnicas de Inativação de Genes
Interferons/antagonistas & inibidores
Macrófagos/virologia
Proteínas Virais/genética
Proteínas Virais/metabolismo
Fatores de Virulência/genética
Fatores de Virulência/metabolismo
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Proteins); 0 (Virulence Factors); 9008-11-1 (Interferons)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE


  8 / 318 MEDLINE  
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[PMID]:28590239
[Au] Autor:Ni S; Yan Y; Cui H; Yu Y; Huang Y; Qin Q
[Ad] Endereço:1​Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, PR China 2​University of Chinese Academy of Sciences, Beijing, 100049, PR China.
[Ti] Título:Fish miR-146a promotes Singapore grouper iridovirus infection by regulating cell apoptosis and NF-κB activation.
[So] Source:J Gen Virol;98(6):1489-1499, 2017 Jun.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:miR-146a was reported to participate in various pathophysiological conditions in mammals, such as inflammation and immune responses, oncogenesis and cell damage. However, its function in low vertebrates has not been well elucidated. In this study, we characterized the expression profiles and functions of miR-146a in fish cells during iridovirus infection. We found that the reported fish miR-146a genes encoded an identical mature sequence, which shared high similarity with its mammalian orthologues, suggesting a putative functional conservation of miR-146a between fish and other vertebrates. Using a well-established infection model of Singapore grouper iridovirus (SGIV) in fathead minnow cells, we found that SGIV infection induced the expression of miR-146a to a dramatic extent. More importantly, we found that miR-146a promoted SGIV propagation, as demonstrated by higher expression of viral genes and increased virus titres in miR-146a-overexpressing cells. Mechanistically, we found that miR-146a overexpression suppressed, while miR-146a knockdown promoted, NF-κB activation and SGIV-induced cell apoptosis, two major cellular events involved in SGIV infection. Our study suggested that the induction of miR-146a by SGIV infection may function through a feed-forward mechanism to promote viral infection by restraining anti-viral cellular responses.
[Mh] Termos MeSH primário: Apoptose
Cyprinidae/virologia
Interações Hospedeiro-Patógeno
MicroRNAs/metabolismo
NF-kappa B/metabolismo
Ranavirus/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); 0 (NF-kappa B)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000811


  9 / 318 MEDLINE  
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[PMID]:28359943
[Au] Autor:Cai J; Wei S; Yu D; Song R; Lu Y; Wu Z; Qin Q; Jian J
[Ad] Endereço:College of Fishery, Guangdong Ocean University, Zhanjiang 524088, PR China; Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animals, Zhanjiang 524088, PR China; Guangdong Key Laboratory of Control for Diseases of Aquatic Economic Animals, Zhanjiang 524
[Ti] Título:BNIP3, a cell pro-apoptotic protein, involved in response to viral infection in orange spotted grouper, Epinephelus coioides.
[So] Source:Fish Shellfish Immunol;64:407-413, 2017 May.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BNIP3 is a kind of BH3-only protein that induces both cell death and autophagy. Here, a BNIP3 gene (EcBNIP3) was identified from orange spotted grouper, Epinephelus coioides. EcBNIP3 possessed 236 amino acids residues, contained a conservative BNIP3 domain and a transmembrane region. Besides, EcBNIP3 expressed at a relative high level in heart and spleen. EcBNIP3 transcript was up-regulated after SGIV infection in vitro. Subcellular localization analysis revealed that EcBNIP3 was predominantly localized in the cytoplasm and co-localized with mitochondria. In addition, overexpression EcBNIP3 accelerated SGIV infection induced cell death but inhibited viral genes transcription. Taken together, these results provided new evidence that fish BNIP3 might involved in response to virus infection.
[Mh] Termos MeSH primário: Proteínas Reguladoras de Apoptose/genética
Bass
Infecções por Vírus de DNA/veterinária
Doenças dos Peixes/genética
Proteínas de Peixes/genética
Ranavirus/fisiologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Proteínas Reguladoras de Apoptose/química
Proteínas Reguladoras de Apoptose/metabolismo
Sequência de Bases
Clonagem Molecular
Infecções por Vírus de DNA/genética
Infecções por Vírus de DNA/virologia
DNA Complementar/genética
DNA Complementar/metabolismo
Doenças dos Peixes/virologia
Proteínas de Peixes/química
Proteínas de Peixes/metabolismo
Filogenia
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Alinhamento de Sequência/veterinária
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apoptosis Regulatory Proteins); 0 (DNA, Complementary); 0 (Fish Proteins); 0 (RNA, Messenger)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


  10 / 318 MEDLINE  
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[PMID]:28081430
[Au] Autor:Wendel ES; Yaparla A; Koubourli DV; Grayfer L
[Ad] Endereço:Department of Biological Sciences, George Washington University, Washington, DC, USA.
[Ti] Título:Amphibian (Xenopus laevis) tadpoles and adult frogs mount distinct interferon responses to the Frog Virus 3 ranavirus.
[So] Source:Virology;503:12-20, 2017 Mar.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Infections of amphibians by Frog Virus 3 (FV3) and other ranavirus genus members are significantly contributing to the amphibian declines, yet much remains unknown regarding amphibian antiviral immunity. Notably, amphibians represent an important step in the evolution of antiviral interferon (IFN) cytokines as they are amongst the first vertebrates to possess both type I and type III IFNs. Accordingly, we examined the roles of type I and III IFNs in the skin of FV3-challenged amphibian Xenopus laevis) tadpoles and adult frogs. Interestingly, FV3-infected tadpoles mounted type III IFN responses, whereas adult frogs relied on type I IFN immunity. Subcutaneous administration of type I or type III IFNs offered short-term protection of tadpoles against FV3 and these type I and type III IFNs induced the expression of distinct antiviral genes in the tadpole skin. Moreover, subcutaneous injection of tadpoles with type III IFN significantly extended their survival and reduced FV3 dissemination.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/imunologia
Interferon Tipo I/imunologia
Interferons/imunologia
Larva/imunologia
Ranavirus/imunologia
Proteínas de Xenopus/imunologia
Xenopus laevis/imunologia
Xenopus laevis/virologia
[Mh] Termos MeSH secundário: Animais
Azetidinas/farmacologia
Citocinas/farmacologia
Infecções por Vírus de DNA/virologia
Interferon Tipo I/farmacologia
Interferons/farmacologia
Larva/virologia
Pele/imunologia
Sulfonamidas/farmacologia
Carga Viral/imunologia
Proteínas de Xenopus/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azetidines); 0 (Cytokines); 0 (Interferon Type I); 0 (Sulfonamides); 0 (Xenopus Proteins); 9008-11-1 (Interferons); ISP4442I3Y (baricitinib)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE



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