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[PMID]:27744059
[Au] Autor:Sánchez-Ortiz AC; Angulo C; Luna-González A; Álvarez-Ruiz P; Mazón-Suástegui JM; Campa-Córdova ÁI
[Ad] Endereço:Centro de Investigaciones Biológicas del Noroeste (CIBNOR), Mar Bermejo 195, Col., Playa Palo de Santa Rita, La Paz, B.C.S., C.P. 23090, Mexico.
[Ti] Título:Effect of mixed-Bacillus spp isolated from pustulose ark Anadara tuberculosa on growth, survival, viral prevalence and immune-related gene expression in shrimp Litopenaeus vannamei.
[So] Source:Fish Shellfish Immunol;59:95-102, 2016 Dec.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The widespread overuse of antibiotics in aquaculture has led to the emergence of antibiotic-resistance shrimp pathogens, the negative impact on shrimp gut microbiota, and the presence of antimicrobial residues in aquaculture products, with negative consequences on human health. Alternatively, probiotics have positive effects on immunological responses and productive performance of aquatic animals. In this study, three probiotic bacteria, (Bacillus licheniformis MAt32, B. subtilis MAt43 and B. subtilis subsp. subtilis GAtB1), isolated from the Anadara tuberculosa were included in diets for juvenile shrimp, Litopenaeus vannamei, to evaluate their effects on growth, survival, disease prevalence, and immune-related gene expression. Shrimp naturally infected with WSSV and IHHNV were fed with the basal diet (control, T1) and diets supplemented with four levels of bacilli probiotic mix (1:1:1) at final concentration of (T2) 1 × 10 , (T3) 2 × 10 , (T4) 4 × 10 , and (T5) 6 × 10 CFU g of feed. The specific growth rate of shrimp was significantly higher in T2 than in T1 (control) treatment, and the final growth as well as the survival were similar among treated groups. The prevalence of WSSV and IHHNV infected shrimp was reduced in T2 and T4 treatments, respectively, compared with control. The mRNA expression of proPO gene was higher in treatment T4 than control. The LvToll1 gene was significantly up-regulated in treatments T4 and T5 compared to control. The SOD gene was up-regulated in treatment T5 compared to control. In contrast, the mRNA expression of the Hsp70 gene was down-regulated in treatments T4 and T5 respect to control, and the TGase gene remained unaffected by the level of bacillus probiotic mix. As conclusion, the bacilli probiotic mix (Bacillus spp.) enhanced immune-related gene expression in WSSV and IHHNV naturally infected shrimp. This is the first report of probiotic potential of bacteria isolated from A. tuberculosa on the immune response and viral prevalence in shrimp Litopenaeus vannamei.
[Mh] Termos MeSH primário: Arcidae/microbiologia
Bacillus/imunologia
Imunidade Inata/imunologia
Penaeidae/efeitos dos fármacos
Penaeidae/fisiologia
Probióticos
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Proteínas de Artrópodes/genética
Proteínas de Artrópodes/metabolismo
Densovirinae/fisiologia
Dieta
Penaeidae/imunologia
Penaeidae/virologia
Probióticos/química
Regulação para Cima
Vírus 1 da Síndrome da Mancha Branca/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arthropod Proteins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


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[PMID]:27605216
[Au] Autor:Phuthaworn C; Nguyen NH; Quinn J; Knibb W
[Ad] Endereço:University of the Sunshine Coast, Locked Bag 4, Maroochydore DC, QLD, 4558, Australia.
[Ti] Título:Moderate heritability of hepatopancreatic parvovirus titre suggests a new option for selection against viral diseases in banana shrimp (Fenneropenaeus merguiensis) and other aquaculture species.
[So] Source:Genet Sel Evol;48(1):64, 2016 09 07.
[Is] ISSN:1297-9686
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In shrimp farming, major production losses are caused by viruses. Hepatopancreatic parvovirus (HPV) is one of the viral pathogens that infect banana shrimp (Fenneropenaeus merguiensis). HPV is thought to slow down growth and cause mortality in the juvenile stages of banana shrimp. Genetic improvement through selection of shrimp resistant to viral diseases is one approach to address this issue. This is the first detailed report on an aquaculture species that investigates whether viral titre varies among families and is heritable, and thus whether viral titre per se is a possible candidate trait for selection to produce resistant stock. RESULTS: HPV titre was measured by quantitative polymerase chain reaction of DNA extracted from 1137 offspring (from 48 full-sib families). Estimated heritability of HPV titre, based on the linear animal mixed model, was moderate (h(2) = 0.41). Genetic correlations of HPV with body traits (weight, length and width of body, head and tail) ranged from -0.13 to -0.38. HPV titre was negatively correlated with raw and cooked body colour (-0.33 and -0.43, respectively). CONCLUSIONS: This is the first study based on a large dataset that provides evidence that viral titre may have a genetic component in penaeid shrimp or even in any aquaculture species. The moderate heritability estimated for this trait suggests that resistance to HPV may be achieved by selecting for low HPV titre. With moderate and negative correlations, selection for resistance to HPV should gradually improve body traits and colour of banana shrimp.
[Mh] Termos MeSH primário: Densovirinae/genética
Penaeidae/genética
Penaeidae/virologia
[Mh] Termos MeSH secundário: Animais
Aquicultura/métodos
Resistência à Doença/genética
Infecções por Rhabdoviridae/genética
Infecções por Rhabdoviridae/prevenção & controle
Infecções por Rhabdoviridae/virologia
Seleção Artificial
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160909
[St] Status:MEDLINE
[do] DOI:10.1186/s12711-016-0243-8


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[PMID]:27568013
[Au] Autor:Chai C; Liu Y; Xia X; Wang H; Pan Y; Yan S; Wang Y
[Ad] Endereço:College of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
[Ti] Título:Prevalence and genomic analysis of infectious hypodermal and hematopoietic necrosis virus (IHHNV) in Litopenaeus vannamei shrimp farmed in Shanghai, China.
[So] Source:Arch Virol;161(11):3189-201, 2016 Nov.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Infectious hypodermal and hematopoietic necrosis virus (IHHNV) is prevalent among farmed shrimp and results in significant reductions in shrimp production. In order to gain a better understanding of the prevalence of IHHNV in the Litopenaeus vannamei shrimp population of Shanghai, China, samples were collected during two cultivation seasons and subjected to diagnostic PCR. The results of this study showed that 167 out of 200 shrimp were positive for IHHNV, indicating a high viral prevalence (83.5 %) in farmed shrimp populations. Our results also indicated that there was a moderate correlation between IHHNV prevalence and water temperature, salinity and pH and only a slight correlation with the concentration of dissolved oxygen (DO). A mathematical model was developed in order to predict the relationship between these four characteristics of water quality and IHHNV prevalence, ultimately resulting in an estimate of the best water quality criteria (IHHNV prevalence = 0) where T = 30 °C pH = 8.0, DO = 18.3 mg/L, and salinity = 1.5 ‰. Additionally, two IHHNV genotypes were identified, the sequencing of which revealed a high similarity to the known IHHNV genotypes based on a comparison of their nucleotide and amino acid sequences. Two types of repetitive sequences were detected at both the 5' and 3' ends of the non-coding regions, which are commonly found in other IHHNV genomic sequences. Phylogenetic analysis indicated that the IHHNV Shanghai genotypes were closely related to strains from Ganyu and Sheyang, but not to strains originating from Fujian, China. This finding suggests that IHHNVs have emerged independently several times in China.
[Mh] Termos MeSH primário: Densovirinae/classificação
Densovirinae/isolamento & purificação
Penaeidae/crescimento & desenvolvimento
Penaeidae/virologia
[Mh] Termos MeSH secundário: Animais
Aquicultura
China
Análise por Conglomerados
DNA Viral/química
DNA Viral/genética
Densovirinae/genética
Genoma Viral
Genótipo
Concentração de Íons de Hidrogênio
Modelos Teóricos
Filogenia
Reação em Cadeia da Polimerase
Prevalência
Salinidade
Análise de Sequência de DNA
Homologia de Sequência
Temperatura Ambiente
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 059QF0KO0R (Water)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170126
[Lr] Data última revisão:
170126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160829
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-016-3022-5


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[PMID]:27169386
[Au] Autor:Yan DC; Huang J; Yang B; Sun HS; Wang YY; Liu X
[Ad] Endereço:College of Agriculture, Ludong University, Yantai, China.
[Ti] Título:Competition of infectious hypodermal and haematopoietic necrosis virus (IHHNV) with white spot syndrome virus (WSSV) for binding to shrimp cellular membrane.
[So] Source:J Fish Dis;39(10):1225-9, 2016 Oct.
[Is] ISSN:1365-2761
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Infectious hypodermal and haematopoietic necrosis virus (IHHNV) and white spot syndrome virus (WSSV) are two widespread shrimp viruses. The interference of IHHNV on WSSV was the first reported case of viral interference that involved crustacean viruses and has been subsequently confirmed. However, the mechanisms underlying the induction of WSSV resistance through IHHNV infection are practically unknown. In this study, the interference mechanisms between IHHNV and WSSV were studied using a competitive ELISA. The binding of WSSV and IHHNV to cellular membrane of Litopenaeus vannamei was examined. The results suggested that there existed a mutual competition between IHHNV and WSSV for binding to receptors present on cellular membrane of L. vannamei and that the inhibitory effects of WSSV towards IHHNV were more distinct than those of IHHNV towards WSSV.
[Mh] Termos MeSH primário: Membrana Celular/virologia
Densovirinae/fisiologia
Penaeidae/virologia
Vírus 1 da Síndrome da Mancha Branca/fisiologia
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160513
[St] Status:MEDLINE
[do] DOI:10.1111/jfd.12489


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[PMID]:26738292
[Au] Autor:Wang Y; Wu J; Gu J
[Ti] Título:[Identification of MicroRNA-like Viral Small RNAs from AaeDV].
[So] Source:Bing Du Xue Bao;31(5):537-41, 2015 Sep.
[Is] ISSN:1000-8721
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Several virus families have been shown to encode microRNAs (miRNAs), which have roles in the infection and replication of viruses in host cells. These virus-encoded miRNAs are identified in double-stranded DNA virus (dsDNA virus) and in several RNA virus families, but not in single-stranded DNA virus (ssDNA virus). We used a bioinformatics approach based on VMir, miRNAFold and MaturePred software to predict virus-encoded miRNA-like small RNAs from the genome of a ssDNA virus: Aedes aegypti densovirus (AaeDV). Northern blotting and stem-loop reverse transcription-polymerase chain reaction (RT-PCR) were used to detect predicted small RNAs. A miRNA-like small RNA termed "AaeDVMD" was identified by stem-loop RT-PCR from predicted candidates. This is the first report demonstrating that a ssDNA virus can encode miRNA-like small RNAs. These data will aid further exploration of the interaction between the AaeDV and its mosquito host.
[Mh] Termos MeSH primário: Aedes/virologia
Densovirinae/genética
MicroRNAs/genética
RNA Viral/genética
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Biologia Computacional
Densovirinae/química
Densovirinae/metabolismo
MicroRNAs/química
MicroRNAs/metabolismo
Dados de Sequência Molecular
RNA Viral/química
RNA Viral/metabolismo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (MicroRNAs); 0 (RNA, Viral)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160108
[St] Status:MEDLINE


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[PMID]:26401891
[Au] Autor:Porse CC; Kramer V; Yoshimizu MH; Metzger M; Hu R; Padgett K; Vugia DJ
[Ti] Título:Public Health Response to Aedes aegypti and Ae. albopictus Mosquitoes Invading California, USA.
[So] Source:Emerg Infect Dis;21(10):1827-9, 2015 Oct.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aedes aegypti and Ae. albopictus mosquitoes, primary vectors of dengue and chikungunya viruses, were recently detected in California, USA. The threat of potential local transmission of these viruses increases as more infected travelers arrive from affected areas. Public health response has included enhanced human and mosquito surveillance, education, and intensive mosquito control.
[Mh] Termos MeSH primário: Densovirinae/patogenicidade
Insetos Vetores/virologia
Controle de Mosquitos/métodos
Saúde Pública/métodos
[Mh] Termos MeSH secundário: Animais
California
Febre de Chikungunya/epidemiologia
Dengue/epidemiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151006
[Lr] Data última revisão:
151006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150925
[St] Status:MEDLINE
[do] DOI:10.3201/3210.150494


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[PMID]:26277910
[Au] Autor:Wei YW; Fan DD; Chen J
[Ad] Endereço:Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Ningbo University, Ningbo 315211, China.
[Ti] Título:Development of an overlapping PCR method to clone the full genome of infectious hypodermal and hematopoietic necrosis virus (IHHNV).
[So] Source:J Virol Methods;224:16-9, 2015 Nov.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Decapod Penstyldensovirus 1, previously named as infectious hypodermal and hematopoietic necrosis virus (IHHNV), is an economically important pathogen that causes shrimp diseases worldwide. However, a rapid method for cloning full-length IHHNV genome sequences is still lacking, which makes it difficult to study the genomics and molecular epidemiology of IHHNV. Here, a novel and rapid PCR technique was developed to determine the complete genomic sequences of IHHNV. The IHHNV genome was amplified in two overlapping fragments which each yielded a 2kb PCR product covering the first half or the second half of IHHNV genome, respectively. Using this method, six complete genomic sequences of IHHNV, which were collected from different regions of Zhejiang province in China, were cloned and sequenced successfully. The new cloning method will greatly facilitate the study on the genomics and molecular epidemiology of IHHNV.
[Mh] Termos MeSH primário: Clonagem Molecular
Densovirinae/genética
Genoma Viral
Reação em Cadeia da Polimerase/métodos
[Mh] Termos MeSH secundário: Animais
China
Análise por Conglomerados
Densovirinae/classificação
Densovirinae/isolamento & purificação
Dados de Sequência Molecular
Penaeidae/virologia
Filogenia
Análise de Sequência de DNA
Homologia de Sequência
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150921
[Lr] Data última revisão:
150921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150818
[St] Status:MEDLINE


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[PMID]:26268797
[Au] Autor:Bochow S; Condon K; Elliman J; Owens L
[Ad] Endereço:College of Public Health, Medical and Veterinary Sciences, James Cook University, 1 Solander Drive, Townsville, Queensland 4811, Australia. Electronic address: shaun.bochow@my.jcu.edu.au.
[Ti] Título:First complete genome of an Ambidensovirus; Cherax quadricarinatus densovirus, from freshwater crayfish Cherax quadricarinatus.
[So] Source:Mar Genomics;24 Pt 3:305-12, 2015 Dec.
[Is] ISSN:1876-7478
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In 1999, the causative agent of an epizootic in Cherax quadricarinatus was described, and given the provisional name Cherax quadricarinatus parvovirus-like. Sequencing of the 6334 nt genome identified three open-reading frames on the top strand coding NS3 (35.55 kDa), NS1 (67.36 kDa) and NS2 (35.18 kDa) and on the bottom strand a single open reading frame which most likely encodes 4 structural proteins. Motifs characteristic of the Densovirinae were found in the ORFs. Phylogenetic analysis of the amino acids in NS1 places the genome in the genus Ambidensovirus, most closely related to the marine sea star densovirus (75%, E=0.0) and distantly related to Acheta domestica densovirus (44.1%). The virus name is proposed as species Decapod ambidensovirus, variant Cherax quadricarinatus densovirus. This is the first Ambidensovirus to be found in decapod crustaceans and the first of the subfamily Densovirinae to be sequenced from a freshwater crayfish. Cherax quadricarinatus densovirus and sea star densovirus are the first highly related Densovirinae to infect phylogenetically disparate hosts and are thus far, unique among the Densovirinae.
[Mh] Termos MeSH primário: Astacoidea/virologia
Densovirinae/genética
Genoma Viral
[Mh] Termos MeSH secundário: Animais
Clonagem Molecular
Densovirinae/isolamento & purificação
Interações Hospedeiro-Patógeno
Filogenia
Reação em Cadeia da Polimerase
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150814
[St] Status:MEDLINE


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[PMID]:26214455
[Au] Autor:Zhao YZ; Chen XL; Zeng DG; Yang CL; Peng M; Chen XH
[Ad] Endereço:Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fisheries Sciences, Nanning, China.
[Ti] Título:Molecular cloning, characterization, and expression of Rab5B, Rab6A, and Rab7 from Litopenaeus vannamei (Penaeidae).
[So] Source:Genet Mol Res;14(3):7740-50, 2015 Jul 13.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The Rab protein family belongs to a superfamily of ras-like GTP-binding proteins. Rab proteins regulate many steps of membrane trafficking. In this study, three Rab family members, Rab5B, Rab6A, and Rab7, designated LvRab5B, LvRab6A, and LvRab7, were cloned from Litopenaeus vannamei. The full-length cDNA sequences of LvRab5B, LvRab6A, and LvRab7 were 1383, 873, and 767 nucleotides in length and they encoded proteins of 211, 212, and 205 amino acids, respectively. Using qRT-PCR, the mRNA expression levels of the three proteins were determined in the hepatopancreas of L. vannamei at different stages after infectious hypodermal and hematopoietic necrosis virus and white spot syndrome virus challenge. The results indicated that the mRNA expression levels of LvRab5B, LvRab6A, and LvRab7 were all significantly up-regulated after virus injection, suggesting that these genes may play essential roles in the immune response to viral infection in shrimp.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica
Penaeidae/genética
Proteínas rab de Ligação ao GTP/genética
Proteínas rab5 de Ligação ao GTP/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Western Blotting
Clonagem Molecular
Densovirinae
Perfilação da Expressão Gênica
Dados de Sequência Molecular
Filogenia
Reação em Cadeia da Polimerase
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Proteínas Recombinantes/metabolismo
Alinhamento de Sequência
Análise de Sequência de DNA
Vírus 1 da Síndrome da Mancha Branca
Proteínas rab de Ligação ao GTP/química
Proteínas rab de Ligação ao GTP/metabolismo
Proteínas rab5 de Ligação ao GTP/química
Proteínas rab5 de Ligação ao GTP/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Rab6 protein); 0 (Recombinant Proteins); 152989-05-4 (rab7 protein); EC 3.6.5.2 (rab GTP-Binding Proteins); EC 3.6.5.2 (rab5 GTP-Binding Proteins)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150728
[St] Status:MEDLINE
[do] DOI:10.4238/2015.July.13.20


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[PMID]:26189118
[Au] Autor:Deseive S; Chen MY; Korosoglou G; Leipsic J; Martuscelli E; Carrascosa P; Mirsadraee S; White C; Hadamitzky M; Martinoff S; Menges AL; Bischoff B; Massberg S; Hausleiter J
[Ad] Endereço:Medizinische Klinik und Poliklinik I der Ludwig-Maximilians-Universität München, Munich, Germany; Institut für Radiologie und Nuklearmedizin; Deutsches Herzzentrum München; Klinik an der Technischen Universität München, Munich, Germany.
[Ti] Título:Prospective Randomized Trial on Radiation Dose Estimates of CT Angiography Applying Iterative Image Reconstruction: The PROTECTION V Study.
[So] Source:JACC Cardiovasc Imaging;8(8):888-96, 2015 Aug.
[Is] ISSN:1876-7591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The purpose of this study was to assess the potential of iterative image reconstruction (IR) of images for radiation dose reduction in coronary computed tomography angiography (CTA). Therefore, IR in combination with 30% tube current reduction was compared with standard scanning with filtered back projection (FBP) reconstruction. BACKGROUND: Lately, new IR techniques with advanced raw data processing have been introduced by different computed tomography vendors, thus allowing for either image noise reduction at unchanged radiation dose levels or radiation dose reductions at comparable image noise levels. METHODS: In this prospective, multicenter, multivendor noninferiority trial, we randomized 400 consecutive patients to 1 of 2 groups: a control group using standard FBP image reconstruction and standard tube current or an interventional group using IR technique and 30% tube current reduction. The primary endpoint was to demonstrate noninferiority in image quality (IQ) in the IR group. IQ was assessed on a 4-point scale (1, nondiagnostic IQ; 4, excellent IQ). Secondary endpoints included total radiation dose estimates and the rate of downstream testing during 30-day follow-up. RESULTS: Median IQ in the IR group was noninferior compared with the conventional FBP group (IR, 3.5 [interquartile range: 3.0 to 4.0]; FBP, 3.4 [interquartile range: 2.8 to 4.0], p for noninferiority <0.016). The radiation exposure was significantly lower in the IR group (median dose-length-product 157 [interquartile range: 114 to 239] mGy·cm vs. 222 [interquartile range: 141 to 319] mGy·cm for IR vs. FBP, respectively, p < 0.0001). The rate of downstream testing did not differ significantly (7.7% vs. 7.9% for IR vs. FBP, respectively, p = 0.94). CONCLUSIONS: Coronary CTA image quality is maintained with the combined use of a 30% reduced tube current and IR algorithms when compared with conventional FBP image reconstruction techniques and standard tube current. (Prospective Randomized Trial On RadiaTion Dose Estimates Of CT AngIOgraphy In PatieNts: NCT01453712).
[Mh] Termos MeSH primário: Angiografia Coronária
Processamento de Imagem Assistida por Computador
Dose de Radiação
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Algoritmos
Densovirinae
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150814
[Lr] Data última revisão:
150814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150720
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE



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