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Viana, Marcos Borato
Martins, Marina Lobato
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[PMID]:26369294
[Au] Autor:dos Santos Brito Silva Furtado M; Viana MB; Hickson Rrios JS; Gontijo RL; Silva CM; do Val Rezende P; de Figueiredo RM; Martins ML
[Ad] Endereço:Serviço de Pesquisa, Fundação Hemominas, Belo Horizonte, Brazil.
[Ti] Título:Prevalence and incidence of erythrovirus B19 infection in children with sickle cell disease: The impact of viral infection in acute clinical events.
[So] Source:J Med Virol;88(4):588-95, 2016 Apr.
[Is] ISSN:1096-9071
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:B19V infection is common during childhood. It is self-limited in healthy individuals, but is often associated with transient aplastic crisis in children with sickle cell disease. The aim of this study was to estimate the prevalence and incidence of B19V infection in children with sickle cell disease screened by the Newborn Screening Program of Minas Gerais, Brazil, and followed-up at Fundação Hemominas. Serum or plasma samples from 278 patients were tested for anti-B19V IgG and IgM using commercial ELISA and for viral DNA using in-house real-time PCR assays; 127 negative-children were retested about 1 year later. The median age of children at first testing was 5.9 years (0.8-12.3). The estimated prevalence of B19V was 29.5 % (95%CI 24.1-34.9 %). The incidence of B19V in those 127 negative-children was 18.2 cases/100 patient-years. All DNA-positive samples were identified as genotype 1, except one sample, in which both genotypes 1 and 3 were identified. It was observed that the higher the child's age, the higher the probability of B19V infection. The analysis of clinical and hematological data showed a significant association of B19V infection with transient aplastic crisis and acute splenic sequestration, higher frequency of transfusions, and higher rate of hospitalization, but not with acute chest syndrome or stroke. These results emphasize the impact of B19V infection on the course of sickle cell disease. Strategies to prevent and monitor B19V infection in children with sickle cell disease should be considered to diminish its morbidity in this susceptible population.
[Mh] Termos MeSH primário: Anemia Falciforme/complicações
Erythrovirus/isolamento & purificação
Infecções por Parvoviridae/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Anticorpos Antivirais/sangue
Brasil/epidemiologia
Criança
Pré-Escolar
DNA Viral/sangue
Ensaio de Imunoadsorção Enzimática
Erythrovirus/classificação
Erythrovirus/genética
Feminino
Variação Genética
Genótipo
Seres Humanos
Imunoglobulina G/sangue
Incidência
Lactente
Masculino
Prevalência
Reação em Cadeia da Polimerase em Tempo Real
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (DNA, Viral); 0 (Immunoglobulin G)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150916
[St] Status:MEDLINE
[do] DOI:10.1002/jmv.24378


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[PMID]:24265024
[Au] Autor:Adamson LA; Fowler LJ; Ewald AS; Clare-Salzler MJ; Hobbs JA
[Ad] Endereço:Departments of Psychiatry and Pediatrics, University of Florida College of Medicine, Gainesville, Florida.
[Ti] Título:Infection and persistence of erythrovirus B19 in benign and cancerous thyroid tissues.
[So] Source:J Med Virol;86(9):1614-20, 2014 Sep.
[Is] ISSN:1096-9071
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human erythrovirus B19 (EVB19) is a small, pathogenic DNA virus that has been associated with a wide range of illnesses. The primary site of replication is in bone marrow-derived erythroid progenitor cells, but EVB19 DNA has been detected in a wide range of organs. Recently, studies have linked EVB19 to thyroid cancers and other thyroid diseases. Previous studies from multiple laboratories have detected EVB19 capsid proteins in Graves' disease, Hashimoto's thyroiditis, and thyroid cancer tissues. Data on viral gene expression and mechanism of infection in the thyroid are lacking. To investigate EVB19 infection and persistence in the thyroid, previously archived adult and pediatric tissue sections were examined for EVB19 DNA, RNA, and capsid proteins, as well as EVB19 receptor P-antigen and co-receptor α5ß1 integrin. EVB19 DNA and protein were detected in a majority of tissues examined (87% and 68%, respectively). Detection was similar in adult and pediatric samples. Quantification of viral genomes revealed no significant difference in the amount of viral DNA in benign, cancerous, or metastatic thyroid tissues. EVB19 capsid RNA was detected in 67% of the tissues examined, confirming at least low-level viral gene expression. Immunohistochemical staining for P-antigen and α5ß1 detected the receptor and co-receptor most frequently on normal thyroid epithelial cells. EVB19 capsid staining could be detected in tumors lacking viral receptors. These results suggest that normal thyroid epithelial cells are the initial target for EVB19 infection in the thyroid and allow for continued persistence in both normal and cancerous thyroid tissues.
[Mh] Termos MeSH primário: Adenoma/virologia
Carcinoma Papilar/virologia
Erythrovirus/genética
Infecções por Parvoviridae/virologia
Glândula Tireoide/virologia
Neoplasias da Glândula Tireoide/virologia
[Mh] Termos MeSH secundário: Adenoma/metabolismo
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Proteínas do Capsídeo/metabolismo
Carcinoma Papilar/metabolismo
Carcinoma Papilar/secundário
Criança
DNA Viral/genética
Feminino
Seres Humanos
Masculino
Meia-Idade
Infecções por Parvoviridae/metabolismo
Infecções por Parvoviridae/patologia
RNA Viral/genética
Glândula Tireoide/metabolismo
Neoplasias da Glândula Tireoide/metabolismo
Neoplasias da Glândula Tireoide/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (DNA, Viral); 0 (RNA, Viral)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:140721
[Lr] Data última revisão:
140721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131123
[St] Status:MEDLINE
[do] DOI:10.1002/jmv.23852


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[PMID]:23765778
[Au] Autor:Page C; Hoffmann TW; Benzerdjeb N; Duverlie G; Sevestre H; Desailloud R
[Ad] Endereço:Department of ENT and Head, Université Picardie Jules Verne et Centre Hospitalier Universitaire (UPJV-CHU Amiens), Amiens, France.
[Ti] Título:Detection of erythrovirus B19 in thyroidectomy specimens from Graves' disease patients: a case-control study.
[So] Source:J Med Virol;85(8):1414-9, 2013 Aug.
[Is] ISSN:1096-9071
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Environmental factors, such as viruses, are thought to contribute to the development of thyroid autoimmunity. Erythrovirus B19 (EVB19) is suspected to be involved in Hashimoto's thyroiditis, but no direct evidence is available concerning the role of EVB19 infection in Graves' disease. The objective of this study was to investigate whether the presence of EVB19 is more frequent in thyroidectomy specimens of patients undergoing thyroidectomy for Graves' disease (cases) than for multinodular thyroid (controls). Serum and thyroidectomy specimens were prospectively collected from 64 patients referred for total thyroidectomy over a 5-year period (2007-2011) and were investigated retrospectively and blindly for circulating EVB19 DNA by q-PCR (Qiagen), and for EVB19 thyrocyte infection by immunochemistry (VP2-Antibody, Dako). EVB19 serology was also determined. General clinical and laboratory data were collected. Twenty patients were referred for Graves' disease and 44 patients were referred for non-autoimmune multinodular thyroid. Patients with thyroid cancer were excluded. Ten percent of Graves' disease patients and 27.7% of control patients had positive staining of thyrocytes for EVB19 antibodies (ns). EVB19-positive and EVB19-negative cases did not differ. EVB19-positive controls were older than EVB19-negative controls (mean age: 57.5 [35-74] vs. 45 [28-80] years, P=0.03) No case of acute EVB19 infection was identified. EVB19-positive serology was more frequent in controls than in Graves' disease patients (88% vs. 45%, P<0.0001). EVB19 was detected in thyrocytes, but not more frequently in Graves' disease patients than in controls. Further studies are needed to determine the role of EVB19 infection in thyroid diseases.
[Mh] Termos MeSH primário: Erythrovirus/isolamento & purificação
Doença de Graves/virologia
Timo/virologia
Tireoidectomia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Anticorpos Antivirais/sangue
Estudos de Casos e Controles
Doença de Graves/cirurgia
Seres Humanos
Masculino
Meia-Idade
Prevalência
Estudos Prospectivos
Estudos Retrospectivos
Soro/virologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:130614
[Lr] Data última revisão:
130614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130615
[St] Status:MEDLINE
[do] DOI:10.1002/jmv.23595


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[PMID]:22542038
[Au] Autor:Cordero E; Folgueira MD; Marcos MÁ; López Medrano F
[Ad] Endereço:Department of Infectious Diseases, Hospital Universitario Virgen del Rocío, Sevilla, Spain. mariae.cordero.sspa@juntadeandalucia.es
[Ti] Título:Other viral infections in solid organ transplantation.
[So] Source:Enferm Infecc Microbiol Clin;30 Suppl 2:70-5, 2012 Mar.
[Is] ISSN:1578-1852
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:Viral infections are a major cause of morbidity and even mortality in solid organ transplant recipients. This article reviews key aspects of infections in solid organ transplant recipients from respiratory viruses, such as influenza, polyomavirus, erythrovirus B19 and measles.
[Mh] Termos MeSH primário: Transplante de Órgãos/efeitos adversos
Viroses/etiologia
[Mh] Termos MeSH secundário: Erythrovirus
Seres Humanos
Influenza Humana/diagnóstico
Influenza Humana/tratamento farmacológico
Influenza Humana/terapia
Sarampo/diagnóstico
Sarampo/etiologia
Sarampo/terapia
Infecções por Parvoviridae/diagnóstico
Infecções por Parvoviridae/etiologia
Infecções por Parvoviridae/terapia
Viroses/diagnóstico
Viroses/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1209
[Cu] Atualização por classe:120430
[Lr] Data última revisão:
120430
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120501
[St] Status:MEDLINE
[do] DOI:10.1016/S0213-005X(12)70085-X


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[PMID]:21116804
[Au] Autor:Doyle S
[Ad] Endereço:Department of Biology, National University Ireland, Maynooth, Ireland. Sean.Doyle@nuim.ie
[Ti] Título:The detection of parvoviruses.
[So] Source:Methods Mol Biol;665:213-31, 2011.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parvovirus B19 is a single-stranded DNA virus which causes severe disease in immunocompromised patients and foetal loss in pregnant women. It is classified as an Erythrovirus and this genus also comprises two related viral genotypes (so-called LaLi/A6 (genotype 2) and V9 (genotype 3)) which appear to be immunologically indistinguishable from Parvovirus B19. Serological and nucleic acid test (NAT) systems to detect Parvovirus B19-mediated infection are commercially available; however, some NAT systems are genotype-specific. International standard preparations of Parvovirus B19 IgG and DNA have been produced for assay standardisation purposes, and to ensure consistency of assay manufacture and performance. Immunological assays, such as B-cell ELISpot, T-cell stimulation, and cytokine detection can also be used to confirm exposure to Parvovirus B19. Immunohistochemical techniques, employing commercially available monoclonal antibodies, are used to localise the virus in infected tissue and Parvovirus B19 viral antigen can also be detected in serum and plasma using antigen-specific ELISA. NAT systems have also been described to detect newly identified parvoviruses such as human bocavirus (HBoV), PARV4, and PARV5, although absolute confirmation of clinical diseases associated with these agents is required. This chapter describes the current status of detection systems for all the aforementioned parvoviruses, with particular emphasis on Erythrovirus detection by serological, NAT, and immunological approaches.
[Mh] Termos MeSH primário: Erythrovirus/genética
Bocavirus Humano/genética
Parvovirinae/isolamento & purificação
Parvovirus B19 Humano/genética
[Mh] Termos MeSH secundário: Anticorpos Antivirais/isolamento & purificação
Linfócitos B/química
Primers do DNA
DNA de Cadeia Simples/genética
DNA Viral/análise
DNA Viral/genética
Ensaio de Imunoadsorção Enzimática
Erythrovirus/imunologia
Feminino
Genótipo
Seres Humanos
Parvovirinae/genética
Parvovirus B19 Humano/imunologia
Parvovirus B19 Humano/fisiologia
Reação em Cadeia da Polimerase/métodos
Gravidez
Sensibilidade e Especificidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (DNA Primers); 0 (DNA, Single-Stranded); 0 (DNA, Viral)
[Em] Mês de entrada:1105
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101201
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-60761-817-1_13


  6 / 35 MEDLINE  
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[PMID]:21151930
[Au] Autor:Chen Z; Chen AY; Cheng F; Qiu J
[Ad] Endereço:Department of Clinical Laboratory, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
[Ti] Título:Chipmunk parvovirus is distinct from members in the genus Erythrovirus of the family Parvoviridae.
[So] Source:PLoS One;5(12):e15113, 2010 Dec 03.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The transcription profile of chipmunk parvovirus (ChpPV), a tentative member of the genus Erythrovirus in the subfamily Parvovirinae of the family Parvoviridae, was characterized by transfecting a nearly full-length genome. We found that it is unique from the profiles of human parvovirus B19 and simian parvovirus, the members in the genus Erythrovirus so far characterized, in that the small RNA transcripts were not processed for encoding small non-structural proteins. However, like the large non-structural protein NS1 of the human parvovirus B19, the ChpPV NS1 is a potent inducer of apoptosis. Further phylogenetic analysis of ChpPV with other parvoviruses in the subfamily Parvovirinae indicates that ChpPV is distinct from the members in genus Erythrovirus. Thus, we conclude that ChpPV may represent a new genus in the family Parvoviridae.
[Mh] Termos MeSH primário: Erythrovirus/genética
Infecções por Parvoviridae/genética
Parvoviridae/genética
[Mh] Termos MeSH secundário: Animais
Apoptose
Células COS
Cercopithecus aethiops
Erythrovirus/classificação
Seres Humanos
Parvoviridae/classificação
Filogenia
Plasmídeos/metabolismo
Sciuridae
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1107
[Cu] Atualização por classe:161207
[Lr] Data última revisão:
161207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0015113


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[PMID]:19951110
[Au] Autor:Ferry T; Hirschel B; Dang T; Meylan P; Delhumeau C; Rauch A; Weber R; Elzi L; Bernasconi E; Schmid P; Calmy A; Swiss HIV Cohort Study
[Ad] Endereço:Geneva University Hospital, Geneva, Switzerland. tristan.ferry@univ-lyon1.f
[Ti] Título:Infrequent replication of parvovirus B19 and erythrovirus genotypes 2 and 3 among HIV-infected patients with chronic anemia.
[So] Source:Clin Infect Dis;50(1):115-8, 2010 Jan 01.
[Is] ISSN:1537-6591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the role that erythroviruses (parvovirus B19 and erythrovirus genotypes 2 and 3) play in the lives of immunosuppressed HIV-infected patients with chronic anemia. We screened the serum samples of 428 patients by specific ultrasensitive real-time polymerase chain reaction assay. Sixteen patients had circulating DNA, with no apparent clinical impact. Erythrovirus-associated anemia is an extremely rare event in HIV-infected patients.
[Mh] Termos MeSH primário: Anemia/virologia
Erythrovirus/fisiologia
Infecções por HIV/virologia
Parvovirus B19 Humano/fisiologia
Replicação Viral
[Mh] Termos MeSH secundário: Adulto
Anemia/sangue
Anemia/complicações
Doença Crônica
Estudos de Coortes
DNA Viral/sangue
Erythrovirus/isolamento & purificação
Feminino
Infecções por HIV/sangue
Infecções por HIV/complicações
Seres Humanos
Masculino
Meia-Idade
Infecções por Parvoviridae/sangue
Infecções por Parvoviridae/complicações
Infecções por Parvoviridae/virologia
Parvovirus B19 Humano/isolamento & purificação
Reação em Cadeia da Polimerase
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1003
[Cu] Atualização por classe:091216
[Lr] Data última revisão:
091216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091203
[St] Status:MEDLINE
[do] DOI:10.1086/649004


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[PMID]:19880339
[Au] Autor:Servant-Delmas A; Mercier M; Laperche S; Lefrère JJ
[Ad] Endereço:Département des agents transmissibles par le sang, Institut national de la transfusion sanguine, 6, rue Alexandre-Cabanel, 75015 Paris, France. aservant@ints.fr
[Ti] Título:[Genetic diversity of human erythroviruses. Consequences on infectious safety of plasma derivatives].
[Ti] Título:Impact de la diversité génétique des erythrovirus humains sur la sécurité infectieuse des médicaments dérivés du sang..
[So] Source:Transfus Clin Biol;16(5-6):482-8, 2009 Nov-Dec.
[Is] ISSN:1953-8022
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The B19 Parvovirus (B19V) has for a long time been considered as the unique human virus belonging to the genus Erythrovirus. The genetic diversity of B19V isolates has been shown to be very low. The isolation of a variant (V9 strain), with a sequence markedly distinct from that of B19V which led to attributing this classification to this family of viruses. Phylogenetic analysis of sequences of V9-related isolates indicates an organization into three well-individualized genotypes. The B19V infection can be transmitted by transfusion. In immunocompetent recipients, B19V exposure by transfusion is most often inconsequential, since a large proportion is immunized. Such an infection may have serious clinical outcome in not immunized patients with shortened red cell survival, seronegative pregnant women and immunocompromised patients. In cellular products, viral DNA detection is not performed, but a preventive strategy could be discussed for at-risk recipients. Whereas in plasma derivatives, B19V screening is performed with a threshold of 10(4)IU/ml using molecular assays. With recent data of a new classification of three genotypes within human erythrovirus, nucleic acid testing assays would be validated in accordance with the genetic variability, in order to guarantee optimal safety. Recently, a new human parvovirus (PARV4) has been discovered. The consequences on blood transfusion of this blood-borne agent and its pathogenicity are still unknown.
[Mh] Termos MeSH primário: Patógenos Transmitidos pelo Sangue
Erythrovirus/genética
Infecções por Parvoviridae/transmissão
Plasma/virologia
Reação Transfusional
[Mh] Termos MeSH secundário: DNA Viral/sangue
Variação Genética
Seres Humanos
Hospedeiro Imunocomprometido/imunologia
Infecções por Parvoviridae/prevenção & controle
Parvovirus B19 Humano/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1002
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091103
[St] Status:MEDLINE
[do] DOI:10.1016/j.tracli.2009.09.001


  9 / 35 MEDLINE  
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Barbosa, Maria Luísa
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[PMID]:19701602
[Au] Autor:Keller LW; Barbosa ML; Melo FL; Pereira LM; David-Neto E; Lanhez LE; Durigon EL
[Ad] Endereço:Institute of Biomedical Science, Department of Microbiology, University of Sao Paulo, Prof. Lineu Prestes 1374, Sao Paulo, Brazil. lilian.keller@usp.br
[Ti] Título:Phylogenetic analysis of a near-full-length sequence of an erythrovirus genotype 3 strain isolated in Brazil.
[So] Source:Arch Virol;154(10):1685-7, 2009.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Human parvovirus B19 is the only member of the genus Erythrovirus that causes human disease. Recent findings of several strains with considerable sequence divergence from B19 have suggested a new classification for parvovirus genotypes as 1 (B19), 2 (A-6 and LaLi) and 3 (V9). In their overall DNA sequence, the three genotypes differ by approximately 10%. Here, we report the isolation of a genotype-3-related strain named BR543 during a prospective study conducted in Sao Paulo, Brazil. Analysis of the nearly full-length genome sequence of BR543 indicates that this B19 variant sequence clusters with Gh2768, a strain from Ghana belonging to subtype 3b, and showed mostly synonymous substitutions.
[Mh] Termos MeSH primário: Erythrovirus/genética
[Mh] Termos MeSH secundário: Sequência de Bases
Brasil
Variação Genética/genética
Genoma Viral/genética
Genótipo
Seres Humanos
Dados de Sequência Molecular
Infecções por Parvoviridae/virologia
Parvovirus B19 Humano/genética
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1002
[Cu] Atualização por classe:091008
[Lr] Data última revisão:
091008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090825
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-009-0482-x


  10 / 35 MEDLINE  
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[PMID]:19494546
[Au] Autor:Johargy A
[Ad] Endereço:Department of Microbiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia. johargy@hotmail.com
[Ti] Título:Seroprevalence of erythrovirus B19 IgG antibody among paediatric patients in Makkah and Jeddah, Kingdom of Saudi Arabia.
[So] Source:Med Princ Pract;18(4):339-41, 2009.
[Is] ISSN:1423-0151
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To estimate the prevalence of IgG antibodies against B19 virus (B19V) in Makkah and Jeddah, Saudi Arabia. METHODS: B19V-specific IgG antibodies were detected by a commercial indirect enzyme-linked immunosorbent assay in sera of 400 paediatric patients (185 males and 215 females) aged 1-17 years. RESULTS: Of the 400 patients, 80 (20%) had sera positive for B19V-specific IgG. The difference in the prevalence of the antibodies between genders was not statistically significant (p = 0.9). The prevalence of anti-B19V antibodies increased significantly in the age group of 12-17 years as compared to younger patients (37.5 vs. 18% in those aged 1-11 years; p = 0.006). CONCLUSION: This study indicated a high prevalence of IgG antibodies against B19V in paediatric patients with an increase in age.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Erythrovirus/imunologia
Imunoglobulina G/sangue
Infecções por Parvoviridae/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Distribuição por Idade
Criança
Pré-Escolar
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Lactente
Masculino
Infecções por Parvoviridae/imunologia
Arábia Saudita/epidemiologia
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Immunoglobulin G)
[Em] Mês de entrada:0908
[Cu] Atualização por classe:090604
[Lr] Data última revisão:
090604
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090605
[St] Status:MEDLINE
[do] DOI:10.1159/000215736



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