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  1 / 277 MEDLINE  
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[PMID]:28125002
[Au] Autor:Kang H; Liu D; Tian J; Hu X; Zhang X; Yin H; Wu H; Liu C; Guo D; Li Z; Jiang Q; Liu J; Qu L
[Ad] Endereço:Division of Zoonosis of Natural Foci, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 678 Haping road, Xiangfang District, Harbin 150000, China. kang1989462@sina.com.
[Ti] Título:Feline Panleucopenia Virus NS2 Suppresses the Host IFN-ß Induction by Disrupting the Interaction between TBK1 and STING.
[So] Source:Viruses;9(1), 2017 Jan 23.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Feline panleucopenia virus (FPV) is a highly infectious pathogen that causes severe diseases in pets, economically important animals and wildlife in China. Although FPV was identified several years ago, little is known about how it overcomes the host innate immunity. In the present study, we demonstrated that infection with the FPV strain Philips-Roxane failed to activate the interferon ß (IFN-ß) pathway but could antagonize the induction of IFN stimulated by Sendai virus (SeV) in F81 cells. Subsequently, by screening FPV nonstructural and structural proteins, we found that only nonstructural protein 2 (NS2) significantly suppressed IFN expression. We demonstrated that the inhibition of SeV-induced IFN-ß production by FPV NS2 depended on the obstruction of the IFN regulatory factor 3 (IRF3) signaling pathway. Further, we verified that NS2 was able to target the serine/threonine-protein kinase TBK1 and prevent it from being recruited by stimulator of interferon genes (STING) protein, which disrupted the phosphorylation of the downstream protein IRF3. Finally, we identified that the C-terminus plus the coiled coil domain are the key domains of NS2 that are required for inhibiting the IFN pathway. Our study has yielded strong evidence for the FPV mechanisms that counteract the host innate immunity.
[Mh] Termos MeSH primário: Vírus da Panleucopenia Felina/imunologia
Interações Hospedeiro-Patógeno
Evasão da Resposta Imune
Interferon beta/antagonistas & inibidores
Proteínas de Membrana/antagonistas & inibidores
Proteínas Serina-Treonina Quinases/antagonistas & inibidores
Proteínas não Estruturais Virais/metabolismo
[Mh] Termos MeSH secundário: Animais
Gatos
Fatores de Virulência/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (Viral Nonstructural Proteins); 0 (Virulence Factors); 77238-31-4 (Interferon-beta); EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE


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[PMID]:27502089
[Au] Autor:Mukhopadhyay HK; Nookala M; Thangamani NR; Sivaprakasam A; Antony PX; Thanislass J; Srinivas MV; Pillai RM
[Ad] Endereço:1 Department of Veterinary Microbiology, Rajiv Gandhi Institute of Veterinary Education and Research, Puducherry, India.
[Ti] Título:Molecular characterisation of parvoviruses from domestic cats reveals emergence of newer variants in India.
[So] Source:J Feline Med Surg;19(8):846-852, 2017 Aug.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives The present study was undertaken to characterise the viral polypeptide 2 (VP2) gene of parvovirus from domestic cats in India. Methods The faecal samples from diarrhoeic/healthy domestic cats were collected from different geographical regions of India for screening by PCR assay followed by sequence analysis of the VP2 gene. Results Canine parvovirus (CPV)/feline panleukopenia virus (FPV) infections were found in 12 (11.3%) of 106 faecal samples tested. Two new CPV-2a (297Ala and Asn426) and three FPV strains were identified by VP2 gene analysis. Several unique and existing amino acid mutations were found, suggesting continuous evolution and emergence of newer variants. The phylogenetic analysis of the CPV sequences revealed that the two new CPV-2a strains from Mumbai (MC8) and Puducherry (P15) were clustered together in a single clade but had evolved independently and were ancestrally related to Chinese CPV-2a isolates. The FPV sequences (T-C-6 and T-C-1) from Thrissur, Kerala, formed a different clade (FPV clade) and were closely related to each other and had an ancestral relationship with an FPV isolate from the USA. Another FPV isolate from Goa (GC1) was positioned in the same clade but had evolved independently. Conclusions and relevance Detection of CPV in both diarrhoeic/healthy cats and the occurrence of FPV infection in a vaccinated cat provide new insights into parvovirus infections in cats in India.
[Mh] Termos MeSH primário: Proteínas do Capsídeo/genética
Vírus da Panleucopenia Felina/isolamento & purificação
Panleucopenia Felina/virologia
Parvovirus Canino/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Gatos
Fezes/virologia
Vírus da Panleucopenia Felina/genética
Feminino
Índia
Masculino
Mutação
Parvovirus Canino/genética
Filogenia
Reação em Cadeia da Polimerase/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (capsid protein VP2, parvovirus B19)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X16661375


  3 / 277 MEDLINE  
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[PMID]:27830988
[Au] Autor:Poncelet L; Garigliany M; Ando K; Franssen M; Desmecht D; Brion JP
[Ad] Endereço:a Laboratory of Anatomy, Biomechanics and Organogenesis, Faculty of Medicine, Université Libre de Bruxelles , Brussels , Belgium.
[Ti] Título:Cell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus.
[So] Source:Cell Cycle;15(24):3482-3489, 2016 Dec 16.
[Is] ISSN:1551-4005
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The cell cycle-associated neuronal death hypothesis, which has been proposed as a common mechanism for most neurodegenerative diseases, is notably supported by evidencing cell cycle effectors in neurons. However, in naturally occurring nervous system diseases, these markers are not expressed in neuron nuclei but in cytoplasmic compartments. In other respects, the Feline Panleukopenia Virus (FPV) is able to complete its cycle in mature brain neurons in the feline species. As a parvovirus, the FPV is strictly dependent on its host cell reaching the cell cycle S phase to start its multiplication. In this retrospective study on the whole brain of 12 cats with naturally-occurring, FPV-associated cerebellar atrophy, VP2 capsid protein expression was detected by immunostaining not only in some brain neuronal nuclei but also in neuronal cytoplasm in 2 cats, suggesting that viral mRNA translation was still occurring. In these cats, double immunostainings demonstrated the expression of cell cycle S phase markers cyclin A, cdk2 and PCNA in neuronal nuclei. Parvoviruses are able to maintain their host cells in S phase by triggering the DNA damage response. S139 phospho H2A1, a key player in the cell cycle arrest, was detected in some neuronal nuclei, supporting that infected neurons were also blocked into the S phase. PCR studies did not support a co-infection with an adeno or herpes virus. ERK1/2 nuclear accumulation was observed in some neurons suggesting that the ERK signaling pathway might be involved as a mechanism driving these neurons far into the cell cycle.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Núcleo Celular/metabolismo
Cérebro/patologia
Vírus da Panleucopenia Felina/fisiologia
Panleucopenia Felina/patologia
Panleucopenia Felina/virologia
Neurônios/patologia
Fase S
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/metabolismo
Especificidade de Anticorpos
Pareamento de Bases
Proteínas do Capsídeo/metabolismo
Gatos
Núcleo Celular/enzimologia
DNA Viral/metabolismo
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Vírus da Panleucopenia Felina/genética
Feminino
Genes Virais
Células HEK293
Seres Humanos
Imuno-Histoquímica
Masculino
Neurônios/virologia
Reação em Cadeia da Polimerase
Reprodutibilidade dos Testes
Tálamo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Biomarkers); 0 (Capsid Proteins); 0 (DNA, Viral); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE
[do] DOI:10.1080/15384101.2016.1249546


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[PMID]:27380652
[Au] Autor:Lane EP; Brettschneider H; Caldwell P; Oosthuizen A; Dalton DL; du Plessis L; Steyl J; Kotze A
[Ad] Endereço:Department of Research and Scientific Services, National Zoological Gardens of South Africa. emily@nzg.ac.za.
[Ti] Título:Feline panleukopaenia virus in captive non-domestic felids in South Africa.
[So] Source:Onderstepoort J Vet Res;83(1):a1099, 2016 Jun 09.
[Is] ISSN:2219-0635
[Cp] País de publicação:South Africa
[La] Idioma:eng
[Ab] Resumo:An outbreak of feline panleukopaenia virus (FPLV) infection was diagnosed by pathology, electron microscopy and polymerase chain reaction (PCR) in vaccinated captive-bred subadult cheetahs in South Africa. Subsequent to this disease outbreak, 12 cases of FPLV diagnosed on histology were confirmed by PCR in captive African black-footed cat, caracal, cheetah, lion, ocelot and serval. Phylogenetic analyses of the viral capsid protein gene on PCR-positive samples, vaccine and National Center for Biotechnology Information (NCBI) reference strains identified a previously unknown strain of FPLV, present since at least 2006, that differs from both the inactivated and the modified live vaccine strains. A previously described South African strain from domestic cats and cheetahs was identified in a serval. Surveys of FPLV strains in South African felids are needed to determine the geographical and host species distribution of this virus. Since non-domestic species may be reservoirs of parvoviruses, and since these viruses readily change host specificity, the risks of FPLV transmission between captive-bred and free-ranging carnivores and domestic cats and dogs warrant further research.
[Mh] Termos MeSH primário: Surtos de Doenças/veterinária
Felidae
Vírus da Panleucopenia Felina/isolamento & purificação
Panleucopenia Felina/epidemiologia
[Mh] Termos MeSH secundário: Acinonyx
Animais
Proteínas do Capsídeo/genética
Gatos
Panleucopenia Felina/diagnóstico
Panleucopenia Felina/patologia
Panleucopenia Felina/virologia
Vírus da Panleucopenia Felina/genética
Feminino
Masculino
Filogenia
Reação em Cadeia da Polimerase/veterinária
Análise de Sequência de DNA/veterinária
África do Sul/epidemiologia
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Capsid Proteins)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160707
[St] Status:MEDLINE
[do] DOI:10.4102/ojvr.v83i1.1099


  5 / 277 MEDLINE  
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[PMID]:26895627
[Au] Autor:Garigliany M; Gilliaux G; Jolly S; Casanova T; Bayrou C; Gommeren K; Fett T; Mauroy A; Lévy E; Cassart D; Peeters D; Poncelet L; Desmecht D
[Ad] Endereço:Department of Morphology and Pathology, University of Liège, Liège, Belgium. mmgarigliany@ulg.ac.be.
[Ti] Título:Feline panleukopenia virus in cerebral neurons of young and adult cats.
[So] Source:BMC Vet Res;12:28, 2016 Feb 19.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Perinatal infections with feline panleukopenia virus (FPV) have long been known to be associated with cerebellar hypoplasia in kittens due to productive infection of dividing neuroblasts. FPV, like other parvoviruses, requires dividing cells to replicate which explains the usual tropism of the virus for the digestive tract, lymphoid tissues and bone marrow in older animals. RESULTS: In this study, the necropsy and histopathological analyses of a series of 28 cats which died from parvovirus infection in 2013 were performed. Infections were confirmed by real time PCR and immunohistochemistry in several organs. Strikingly, while none of these cats showed cerebellar atrophy or cerebellar positive immunostaining, some of them, including one adult, showed a bright positive immunostaining for viral antigens in cerebral neurons (diencephalon). Furthermore, infected neurons were negative by immunostaining for p27(Kip1), a cell cycle regulatory protein, while neighboring, uninfected, neurons were positive, suggesting a possible re-entry of infected neurons into the mitotic cycle. Next-Generation Sequencing and PCR analyses showed that the virus infecting cat brains was FPV and presented a unique substitution in NS1 protein sequence. Given the role played by this protein in the control of cell cycle and apoptosis in other parvoviral species, it is tempting to hypothesize that a cause-to-effect between this NS1 mutation and the capacity of this FPV strain to infect neurons in adult cats might exist. CONCLUSIONS: This study provides the first evidence of infection of cerebral neurons by feline panleukopenia virus in cats, including an adult. A possible re-entry into the cell cycle by infected neurons has been observed. A mutation in the NS1 protein sequence of the FPV strain involved could be related to its unusual cellular tropism. Further research is needed to clarify this point.
[Mh] Termos MeSH primário: Cérebro/virologia
Vírus da Panleucopenia Felina/isolamento & purificação
Panleucopenia Felina/virologia
Neurônios/virologia
[Mh] Termos MeSH secundário: Animais
Antígenos Virais/análise
Gatos
DNA Viral/análise
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Viral); 0 (DNA, Viral)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160222
[Lr] Data última revisão:
160222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160221
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-016-0657-0


  6 / 277 MEDLINE  
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[PMID]:25979281
[Au] Autor:Hellard E; Pontier D; Siberchicot A; Sauvage F; Fouchet D
[Ad] Endereço:Université de Lyon, Université Lyon1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, 43 Bd du 11 novembre 1918, F-69622, Villeurbanne, France. Electronic address: eleonore.hellard@gmail.com.
[Ti] Título:Unknown age in health disorders: A method to account for its cumulative effect and an application to feline viruses interactions.
[So] Source:Epidemics;11:48-55, 2015 Jun.
[Is] ISSN:1878-0067
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Parasite interactions have been widely evidenced experimentally but field studies remain rare. Such studies are essential to detect interactions of interest and access (co)infection probabilities but face methodological obstacles. Confounding factors can create statistical associations, i.e. false parasite interactions. Among them, host age is a crucial covariate. It influences host exposition and susceptibility to many infections, and has a mechanical effect, older individuals being more at risk because of a longer exposure time. However, age is difficult to estimate in natural populations. Hence, one should be able to deal at least with its cumulative effect. Using a SI type dynamic model, we showed that the cumulative effect of age can generate false interactions theoretically (deterministic modeling) and with a real dataset of feline viruses (stochastic modeling). The risk to wrongly conclude to an association was maximal when parasites induced long-lasting antibodies and had similar forces of infection. We then proposed a method to correct for this effect (and for other potentially confounding shared risk factors) and made it available in a new R package, Interatrix. We also applied the correction to the feline viruses. It offers a way to account for an often neglected confounding factor and should help identifying parasite interactions in the field, a necessary step towards a better understanding of their mechanisms and consequences.
[Mh] Termos MeSH primário: Calicivirus Felino/isolamento & purificação
Gatos/virologia
Vírus da Panleucopenia Felina/isolamento & purificação
Herpesviridae/isolamento & purificação
Vírus da Imunodeficiência Felina/isolamento & purificação
Modelos Estatísticos
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Gatos/imunologia
Interações Hospedeiro-Parasita
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150518
[Lr] Data última revisão:
150518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150517
[St] Status:MEDLINE


  7 / 277 MEDLINE  
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[PMID]:24820998
[Au] Autor:Roberts ES; VanLare KA; Roycroft LM; King S
[Ad] Endereço:Novartis Animal Health US, Greensboro, NC, USA elizabeth.roberts@novartis.com.
[Ti] Título:Effect of high-dose ciclosporin on the immune response to primary and booster vaccination in immunocompetent cats.
[So] Source:J Feline Med Surg;17(2):101-9, 2015 Feb.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ciclosporin (Atopica oral solution for cats 100 mg/ml; Novartis Animal Health) was recently approved for use in cats with feline hypersensitivity dermatitis. The immunosuppressant effect of ciclosporin on the ability of cats to mount an immune response following vaccination was determined. Thirty-two healthy, immunocompetent adult cats (16 cats/group) were treated with either ciclosporin for 56 days at a dose of 24 mg/kg once daily or sham dosed. Prior to treatment, cats had an adequate antibody response to primary vaccination against feline calicivirus (FCV), feline herpesvirus-1 (FHV-1), feline panleukopenia virus (FPV), feline leukemia virus (FeLV) and rabies. Booster vaccination or novel vaccination with feline immunodeficiency virus (FIV) was administered 28 days after initiation of treatment with ciclosporin. There were no differences between the ciclosporin-treated and control cats for FCV and FPV antibody titers following booster vaccination. There were delays/reductions in antibody response to FHV-1, FeLV and rabies in treated cats; however, adequate protection was achieved in response to all booster vaccinations. Following primary vaccination with FIV, control cats showed a response, but treated cats showed no antibody production. Adverse events commonly associated with ciclosporin treatment, including diarrhea/loose stool, vomiting, salivation and regurgitation, were reported. In adult cats treated with 24 mg/kg/day of ciclosporin (more than three times the therapeutic dose), vaccine titer levels were adequate for protection following booster vaccination. In contrast, treated cats failed to mount a humoral response to a novel (FIV) vaccination, suggesting that memory B-cell immune responses remain intact during repeated high-dose ciclosporin administration in cats, but that primary immune responses are impaired.
[Mh] Termos MeSH primário: Doenças do Gato/tratamento farmacológico
Doenças do Gato/imunologia
Ciclosporina/administração & dosagem
Fármacos Dermatológicos/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/imunologia
Infecções por Caliciviridae/veterinária
Calicivirus Felino/imunologia
Gatos
Vírus da Panleucopenia Felina/imunologia
Herpesviridae/imunologia
Vírus da Imunodeficiência Felina/imunologia
Vacinação/veterinária
Vacinas Virais/administração & dosagem
Vacinas Virais/imunologia
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Dermatologic Agents); 0 (Viral Vaccines); 83HN0GTJ6D (Cyclosporine)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140514
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X14533550


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[PMID]:24923754
[Au] Autor:Stuetzer B; Hartmann K
[Ad] Endereço:Clinic of Small Animal Medicine, Faculty of Veterinary Medicine, Ludwig-Maximilians- Universität Muenchen, Munich, Germany. Electronic address: b.stuetzer@gmx.de.
[Ti] Título:Feline parvovirus infection and associated diseases.
[So] Source:Vet J;201(2):150-5, 2014 Aug.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Feline panleukopenia, caused by the single-stranded DNA virus feline parvovirus (FPV), is a highly contagious and often lethal disease of cats and other Felidae. FPV, but also canine parvovirus (CPV) can be isolated from both healthy and diseased cats. In Germany, CPV was detected in only approximately 10% of feline samples, but in Southeast Asia, reports estimated that up to approximately 80% of diseased cats were infected with CPV. Infection spreads rapidly, especially in cells with high mitotic activity, such as bone marrow, lymphoid tissue and intestinal crypt cells. Anorexia, vomiting, diarrhoea, neutropenia and lymphopenia are common in clinically affected cases. In utero or neonatal infection can result in cerebellar hypoplasia. Depending on the severity of clinical signs, mortality ranges from 25 to 100%. Effective vaccination and thorough disinfection are of the utmost importance in the prevention of disease transmission in multi-cat households and animal shelters. If clinical signs develop, supportive treatment should be commenced. The efficacy of feline recombinant interferon and FPV antibodies has not been clearly demonstrated. Commercially available vaccines should induce protective immunity when administered according to current guidelines. Recent studies suggest that in some kittens, maternally derived antibodies (MDA) can persist for much longer than has been previously recognised. FPV serum antibody tests are available, but protection status needs to be interpreted with caution in kittens with MDA and a negative titre in adult cats does not necessarily denote lack of protection.
[Mh] Termos MeSH primário: Vírus da Panleucopenia Felina/fisiologia
Panleucopenia Felina
[Mh] Termos MeSH secundário: Animais
Gatos
Panleucopenia Felina/diagnóstico
Panleucopenia Felina/epidemiologia
Panleucopenia Felina/terapia
Panleucopenia Felina/virologia
Vírus da Panleucopenia Felina/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1504
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140614
[St] Status:MEDLINE


  9 / 277 MEDLINE  
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[PMID]:24496322
[Au] Autor:Mende K; Stuetzer B; Truyen U; Hartmann K
[Ad] Endereço:Clinic of Small Animal Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany katherina.mende@googlemail.com.
[Ti] Título:Evaluation of an in-house dot enzyme-linked immunosorbent assay to detect antibodies against feline panleukopenia virus.
[So] Source:J Feline Med Surg;16(10):805-11, 2014 Oct.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Measuring antibody titres to determine a cat's immunity to core diseases instead of just administering annual vaccinations has not been established in Germany so far. An in-house test kit for the detection of antibodies against feline panleukopenia virus (FPV), feline herpesvirus-1 and feline calicivirus-- the ImmunoComb Feline VacciCheck--is now available in several European countries. The aim of this study was to assess the quality of the ImmunoComb Feline VacciCheck to determine antibodies by comparing it to a gold standard. The test is aimed for use in practice to assist decision-making when performing an individual health assessment to see whether a cat is potentially unprotected against FPV and requires FPV vaccination. Sera from 347 cats were included in the study. For antibody detection, haemagglutination inhibition (HI) was performed as gold standard. Sensitivity, specificity and positive and negative predictive values of the ImmunoComb Feline VacciCheck were determined for three different HI titre cut-off points (1:20, 1:40, 1:80). In comparison to the HI, the ImmunoComb Feline VacciCheck showed a sensitivity of 79%, 83% and 87%, and a specificity of 89%, 86% and 81%, respectively. Specificity of the ImmunoComb Feline VacciCheck, which was considered the most important parameter, was acceptable in comparison to HI. Especially when considering an antibody titre of 1:20 sufficient for protection (eg, in an adult animal), the ImmunoComb Feline VacciCheck can be recommended for use in veterinary practice.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Ensaio de Imunoadsorção Enzimática/veterinária
Vírus da Panleucopenia Felina/imunologia
Panleucopenia Felina/diagnóstico
[Mh] Termos MeSH secundário: Animais
Gatos
Ensaio de Imunoadsorção Enzimática/métodos
Panleucopenia Felina/imunologia
Panleucopenia Felina/prevenção & controle
Feminino
Masculino
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140206
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X14520812


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[PMID]:24461646
[Au] Autor:Mende K; Stuetzer B; Sauter-Louis C; Homeier T; Truyen U; Hartmann K
[Ad] Endereço:Clinic of Small Animal Medicine, Ludwig-Maximilians-Universitaet of Munich, Veterinaerstrasse 13, 80539 Munich, Germany. Electronic address: katherina.mende@googlemail.com.
[Ti] Título:Prevalence of antibodies against feline panleukopenia virus in client-owned cats in Southern Germany.
[So] Source:Vet J;199(3):419-23, 2014 Mar.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Feline panleukopenia is a frequent and commonly fatal disease of cats. Recent published studies have raised suspicions that some cats fail to develop antibodies after vaccination. The purpose of this study was to assess the prevalence of antibodies against feline panleukopenia virus (FPV) in cats in Southern Germany, and to identify factors that are associated with a lack of antibodies. In total, 350 cats presented to the Clinic of Small Animal Medicine, Ludwig-Maximilians-Universitaet were randomly included in the study. Information regarding signalment, origin, environment, lifestyle, housing conditions, health status, chronic diseases, glucocorticoid therapy, and vaccination status were collected. Antibodies were detected by haemagglutination inhibition test. Asymptomatic chi-squared tests and univariable logistic regression were used to investigate associations between a lack of antibodies and the different variables. Associations determined to be statistically significant at P<0.1 were verified by a multivariable logistic regression analysis. Of the 350 cats, 103 (29.4%) had no antibodies against FPV. Chronic kidney disease, neoplasia, glucocorticoid therapy, and vaccination status were significantly associated with a lack of antibodies. The cats with no antibodies were likely to have inadequate immunity against panleukopenia and those with chronic diseases or receiving glucocorticoids were less likely to be protected.
[Mh] Termos MeSH primário: Vírus da Panleucopenia Felina/imunologia
Panleucopenia Felina/epidemiologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/sangue
Gatos
Distribuição de Qui-Quadrado
Panleucopenia Felina/imunologia
Panleucopenia Felina/virologia
Feminino
Alemanha/epidemiologia
Testes de Inibição da Hemaglutinação/veterinária
Modelos Logísticos
Masculino
Análise Multivariada
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140128
[St] Status:MEDLINE



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