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Referências encontradas : 373 [refinar]
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[PMID]:29385360
[Au] Autor:Boylston AW
[Ad] Endereço:From the Nuffield Division of Clinical Laboratory Sciences-Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
[Ti] Título:The Myth of the Milkmaid.
[So] Source:N Engl J Med;378(5):414-415, 2018 Feb 01.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Varíola Bovina/história
Fazendeiros/história
Imunização/história
Vacina Antivariólica/história
Varíola/história
[Mh] Termos MeSH secundário: Animais
Bovinos
Varíola Bovina/imunologia
Inglaterra
Feminino
História do Século XVIII
História do Século XIX
Seres Humanos
Mitologia
Orthopoxvirus/imunologia
Varíola/prevenção & controle
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Fewster J; Jenner E
[Nm] Nome de substância:
0 (Smallpox Vaccine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMp1715349


  2 / 373 MEDLINE  
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[PMID]:29351298
[Au] Autor:Noyce RS; Lederman S; Evans DH
[Ad] Endereço:Department of Medical Microbiology & Immunology and Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
[Ti] Título:Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments.
[So] Source:PLoS One;13(1):e0188453, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Edward Jenner and his contemporaries believed that his variolae vaccinae originated in horses and molecular analyses show that modern vaccinia virus (VACV) strains share common ancestry with horsepox virus (HPXV). Given concerns relating to the toxicity of modern VACV vaccines, we asked whether an HPXV-based vaccine might provide a superior alternative. Since HPXV may be extinct and the only specimen of HPXV that has been identified is unavailable for investigation, we explored whether HPXV could be obtained by large-scale gene synthesis. Ten large (10-30 kb) fragments of DNA were synthesized based on the HPXV sequence along with two 157 nt VACV terminal sequences, and were recombined into a live synthetic chimeric HPXV (scHPXV) in cells infected with Shope fibroma virus (SFV). Sequencing of the 212 kbp scHPXV confirmed it encoded a faithful copy of the input DNA. We believe this is the first complete synthesis of a poxvirus using synthetic biology approaches. This scHPXV produced smaller plaques, produced less extracellular virus and exhibited less virulence in mice than VACV, but still provided vaccine protection against a lethal VACV challenge. Collectively, these findings support further development of scHPXV as a novel replication-proficient smallpox vaccine.
[Mh] Termos MeSH primário: DNA/química
Orthopoxvirus/imunologia
Vacinas Sintéticas/imunologia
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Cercopithecus aethiops
Células HeLa
Seres Humanos
Camundongos
Orthopoxvirus/crescimento & desenvolvimento
Orthopoxvirus/patogenicidade
Vacinas Sintéticas/administração & dosagem
Células Vero
Vacinas Virais/administração & dosagem
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Vaccines, Synthetic); 0 (Viral Vaccines); 9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188453


  3 / 373 MEDLINE  
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[PMID]:29020595
[Au] Autor:Schrick L; Tausch SH; Dabrowski PW; Damaso CR; Esparza J; Nitsche A
[Ad] Endereço:Robert Koch Institute, Berlin, Germany.
[Ti] Título:An Early American Smallpox Vaccine Based on Horsepox.
[So] Source:N Engl J Med;377(15):1491-1492, 2017 10 12.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças dos Cavalos/virologia
Orthopoxvirus/genética
Vacina Antivariólica/história
Varíola/história
Vírus Vaccinia/genética
[Mh] Termos MeSH secundário: Animais
Genoma Viral
História do Século XIX
História do Século XX
Cavalos
Seres Humanos
Varíola/prevenção & controle
Varíola/veterinária
Varíola/virologia
Vírus Vaccinia/imunologia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Smallpox Vaccine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1707600


  4 / 373 MEDLINE  
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[PMID]:28802157
[Au] Autor:Americo JL; Earl PL; Moss B
[Ad] Endereço:Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States.
[Ti] Título:Droplet digital PCR for rapid enumeration of viral genomes and particles from cells and animals infected with orthopoxviruses.
[So] Source:Virology;511:19-22, 2017 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Droplet digital polymerase chain reaction (ddPCR) was adapted for quantifying the number of orthopoxviral genomes in purified virus samples, infected cell lysates and tissues of infected animals. In contrast to the more commonly used qPCR, the newer ddPCR provides absolute numbers of DNA copies in samples without need for standard curves and has the ability to detect rare mutants in a population. The genome/infectious unit ratio for several sucrose gradient-purified orthopoxviruses varied from 5 to 10, which correlated well with values obtained using the Virocyt, a dedicated fluorescence flow cytometer. By employing a nuclease step to digest unencapsulated DNA, the genome/infectious unit ratios of virus in crude cell lysates approached that of purified virus particles. The speed, accuracy, sensitivity, and dynamic range of less than one to millions of infectious units in a sample make this semi-automated method well suited to a variety of laboratory, animal and clinical studies.
[Mh] Termos MeSH primário: Orthopoxvirus/isolamento & purificação
Reação em Cadeia da Polimerase/métodos
Carga Viral/métodos
[Mh] Termos MeSH secundário: Animais
Automação Laboratorial
Orthopoxvirus/genética
Sensibilidade e Especificidade
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE


  5 / 373 MEDLINE  
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[PMID]:28131867
[Au] Autor:Hughes L; Wilkins K; Goldsmith CS; Smith S; Hudson P; Patel N; Karem K; Damon I; Li Y; Olson VA; Satheshkumar PS
[Ad] Endereço:Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA. Electronic address: bkz2@cdc.gov.
[Ti] Título:A rapid Orthopoxvirus purification protocol suitable for high-containment laboratories.
[So] Source:J Virol Methods;243:68-73, 2017 May.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Virus purification in a high-containment setting provides unique challenges due to barrier precautions and operational safety approaches that are not necessary in lower biosafety level (BSL) 2 environments. The need for high risk group pathogen diagnostic assay development, anti-viral research, pathogenesis and vaccine efficacy research necessitates work in BSL-3 and BSL-4 labs with infectious agents. When this work is performed in accordance with BSL-4 practices, modifications are often required in standard protocols. Classical virus purification techniques are difficult to execute in a BSL-3 or BSL-4 laboratory because of the work practices used in these environments. Orthopoxviruses are a family of viruses that, in some cases, requires work in a high-containment laboratory and due to size do not lend themselves to simpler purification methods. Current CDC purification techniques of orthopoxviruses uses 1,1,2-trichlorotrifluoroethane, commonly known as Genetron . Genetron is a chlorofluorocarbon (CFC) that has been shown to be detrimental to the ozone and has been phased out and the limited amount of product makes it no longer a feasible option for poxvirus purification purposes. Here we demonstrate a new Orthopoxvirus purification method that is suitable for high-containment laboratories and produces virus that is not only comparable to previous purification methods, but improves on purity and yield.
[Mh] Termos MeSH primário: Orthopoxvirus/isolamento & purificação
Virologia/métodos
[Mh] Termos MeSH secundário: Animais
Contenção de Riscos Biológicos
Seres Humanos
Laboratórios
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


  6 / 373 MEDLINE  
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[PMID]:28055328
[Au] Autor:Khalafalla AI; Abdelazim F
[Ad] Endereço:1 Department of Veterinary Laboratories, Abu Dhabi Food Control Authority , Abu Dhabi, United Arab Emirates .
[Ti] Título:Human and Dromedary Camel Infection with Camelpox Virus in Eastern Sudan.
[So] Source:Vector Borne Zoonotic Dis;17(4):281-284, 2017 Apr.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We provide evidence for the zoonotic nature of camelpox virus by reporting infections that involved dromedary camels and three camel herders in Showak area of eastern Sudan between September and December 2014. The skin lesions in the camel herders consisted of erythema, vesicles, and pustules that involved arms, hands, legs, back, and abdomen and resolved within less than 2 months with no human-to-human transmission. The diagnosis was achieved through molecular technique, virus isolation in cell culture, and partial genome sequencing.
[Mh] Termos MeSH primário: Camelus/virologia
Orthopoxvirus/isolamento & purificação
Infecções por Poxviridae/veterinária
[Mh] Termos MeSH secundário: Adulto
Animais
Surtos de Doenças
Seres Humanos
Masculino
Meia-Idade
Orthopoxvirus/genética
Filogenia
Infecções por Poxviridae/epidemiologia
Infecções por Poxviridae/transmissão
Infecções por Poxviridae/virologia
Sudão/epidemiologia
Adulto Jovem
Zoonoses
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2016.2070


  7 / 373 MEDLINE  
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Weiblen, Rudi
Texto completo
[PMID]:27793645
[Au] Autor:Cargnelutti JF; Weiblen R; Flores EF
[Ad] Endereço:Departamento de Medicina Veterinária Preventiva, Universidade Federal de Santa Maria, Av. Roraima, 1000, building 63A, Santa Maria, Rio Grande do Sul, zip-code 97105-900, Brazil.
[Ti] Título:A multiplex PCR for viruses associated with exanthematic and vesicular disease in cattle.
[So] Source:J Virol Methods;239:38-41, 2017 Jan.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Exanthematic and papulo-vesicular lesions in the udder and teats of milking cows are fairly common in some Brazilian dairies, especially those with poor sanitary conditions and hand milking. The orthopoxvirus Vaccinia virus (VACV) and the parapoxviruses Pseudocowpox virus (PCPV) and Bovine popular stomatitis virus (BPSV) have been frequently associated with such conditions. Elsewhere, Bovine herpesvirus 2 (BoHV-2) has also been associated with similar clinical signs. Thus, we herein describe a conventional multiplex PCR designed to detect the genome of these viruses in clinical samples while differentiating among them by amplicon size. For this, primer sets targeting the orthopoxvirus vascular growth factor (amplicon size 292bp), PCPV (374bp) and BSPV (607bp) B2L genes, and the BoHV-2 DNA polymerase gene (138bp) were selected. The chosen primers anneal within the same temperature range and do not interfere with each other during the PCR amplification. PCR conditions were initially standardized for each agent in individual PCR reactions firstly using the target virus as positive control followed by using a mixture of all four virues. Lastly, a multiplex PCR containing the four sets of primers was set up to amplify all four targeted viruses in one reaction. The multiplex PCR was able to detect DNA extracted from cell culture supernatants containing 20 TCID of BoHV-2 and 50 TCID of VACV. Further, the test could detect the viral genomes in 1:10, 1:50 and 1:1000 dilutions of total DNA extracted from clinical specimens (e.g. scabs, crusts) of natural cases (PCPV, VACV and BPSV) and 1:10 dilutions of DNA extracted from scabs collected from BoHV-2 experimentally infected cattle. A possible amplification of other orthopoxviruses, predicted by in silico analysis, was considered to not represent an important pitfall since these are exotic in Brazil, very rare, or viruses not associated with cattle. For definitive agent identification amplicon sequencing needs to be conducted. Thus, this multiplex PCR seems suitable for initial detection and identification of the agents involved in exanthematic and vesicular disease, providing a sensitive and specific diagnosis for such conditions in dairy cows.
[Mh] Termos MeSH primário: Doenças dos Bovinos/diagnóstico
Doenças dos Bovinos/virologia
Reação em Cadeia da Polimerase Multiplex/métodos
Infecções por Poxviridae/veterinária
[Mh] Termos MeSH secundário: Animais
Brasil
Bovinos
Primers do DNA
DNA Viral/genética
Genes Virais
Genoma Viral
Orthopoxvirus/genética
Orthopoxvirus/isolamento & purificação
Parapoxvirus/genética
Parapoxvirus/isolamento & purificação
Infecções por Poxviridae/diagnóstico
Infecções por Poxviridae/virologia
Vírus da Pseudovaríola das Vacas/genética
Vírus da Pseudovaríola das Vacas/isolamento & purificação
Vírus Vaccinia/genética
Vírus Vaccinia/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Primers); 0 (DNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


  8 / 373 MEDLINE  
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[PMID]:27613417
[Au] Autor:Smithson C; Tang N; Sammons S; Frace M; Batra D; Li Y; Emerson GL; Carroll DS; Upton C
[Ad] Endereço:Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
[Ti] Título:The genomes of three North American orthopoxviruses.
[So] Source:Virus Genes;53(1):21-34, 2017 Feb.
[Is] ISSN:1572-994X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The complete genomes of a skunkpox, volepox, and raccoonpox virus were sequenced and annotated. Phylogenetic analysis of these genomes indicates that although these viruses are all orthopoxviruses, they form a distinct clade to the other known species. This supports the ancient divergence of the North American orthopoxviruses from other members of the orthopoxviruses. Only two open reading frames appear to be unique to this group of viruses, but a relatively small number of insertions/deletions contribute to the varied gene content of this clade. The availability of these genomes will help determine whether skunkpox and volepox viruses share the characteristics that make raccoonpox a useful vaccine vector.
[Mh] Termos MeSH primário: Genoma Viral
Orthopoxvirus/classificação
Orthopoxvirus/genética
Infecções por Poxviridae/epidemiologia
Infecções por Poxviridae/virologia
[Mh] Termos MeSH secundário: Animais
Biologia Computacional/métodos
Regulação Viral da Expressão Gênica
Seres Humanos
Anotação de Sequência Molecular
Mutação
América do Norte/epidemiologia
Fases de Leitura Aberta
Filogenia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160911
[St] Status:MEDLINE
[do] DOI:10.1007/s11262-016-1388-9


  9 / 373 MEDLINE  
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[PMID]:27938377
[Au] Autor:Stern D; Olson VA; Smith SK; Pietraszczyk M; Miller L; Miethe P; Dorner BG; Nitsche A
[Ad] Endereço:Centre for Biological Threats and Special Pathogens (ZBS), Robert Koch Institute, Seestrasse 10, 13353, Berlin, Germany. SternD@rki.de.
[Ti] Título:Rapid and sensitive point-of-care detection of Orthopoxviruses by ABICAP immunofiltration.
[So] Source:Virol J;13(1):207, 2016 Dec 09.
[Is] ISSN:1743-422X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The rapid and reliable detection of infectious agents is one of the most challenging tasks in scenarios lacking well-equipped laboratory infrastructure, like diagnostics in rural areas of developing countries. Commercially available point-of-care diagnostic tests for emerging and rare diseases are particularly scarce. RESULTS: In this work we present a point-of-care test for the detection of Orthopoxviruses (OPV). The OPV ABICAP assay detects down to 1 × 10 plaque forming units/mL of OPV particles within 45 min. It can be applied to clinical material like skin crusts and detects all zoonotic OPV infecting humans, including Vaccinia, Cowpox, Monkeypox, and most importantly Variola virus. CONCLUSIONS: Given the high sensitivity and the ease of handling, the novel assay could be highly useful for on-site diagnostics of suspected Monkeypox virus infections in areas lacking proper laboratory infrastructure as well as rapid on-site testing of suspected bioterrorism samples.
[Mh] Termos MeSH primário: Filtração/métodos
Imunoensaio/métodos
Orthopoxvirus/isolamento & purificação
Sistemas Automatizados de Assistência Junto ao Leito
Infecções por Poxviridae/diagnóstico
Infecções por Poxviridae/veterinária
Virologia/métodos
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Sensibilidade e Especificidade
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  10 / 373 MEDLINE  
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[PMID]:27721109
[Au] Autor:Fevola C; Forbes KM; Mäkelä S; Putkuri N; Hauffe HC; Kallio-Kokko H; Mustonen J; Jääskeläinen AJ; Vaheri A
[Ad] Endereço:Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Biodiversity and Molecular Ecology, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, TN, Italy. Electronic address: cristina.fevola@helsinki.fi.
[Ti] Título:Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection.
[So] Source:J Clin Virol;84:48-52, 2016 11.
[Is] ISSN:1873-5967
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. Prominent rodent-borne zoonotic viruses include Puumala hantavirus (PUUV; the causative agent of nephropathia epidemica, NE), lymphocytic choriomeningitis virus (LCMV), and orthopoxviruses (OPV). In addition, Ljungan virus (LV) is considered a potentially zoonotic virus. OBJECTIVE: The aim of this study was to compare clinical picture between acute PUUV patients with and without additional rodent-borne viral infections, to investigate if concurrent infections influence disease severity. STUDY DESIGN: We evaluated seroprevalence of and seroconversions to LCMV, LV and OPV in 116 patients hospitalized for NE. Clinical and laboratory variables were closely monitored during hospital care. RESULTS: A total of five LCMV, 15 LV, and one OPV seroconversions occurred. NE patients with LCMV seroconversions were younger, and had lower plasma creatinine concentrations and platelet counts than patients without LCMV seroconversions. No differences occurred in clinical or laboratory findings between patients with and without seroconversions to LV and OPV. We report, for the first time, LCMV seroprevalence in Finland, with 8.5% of NE patients seropositive for this virus. Seroprevalences for LV and OPV were 47.8% and 32.4%, respectively. CONCLUSION: Cases with LCMV seroconversions were statistically younger, had milder acute kidney injury and more severe thrombocytopenia than patients without LCMV. However, the low number of seroconversion cases precludes firm conclusions. Concurrent LV or OPV infections do not appear to influence clinical picture for NE patients.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Coinfecção
Febre Hemorrágica com Síndrome Renal/complicações
Coriomeningite Linfocítica/complicações
Orthopoxvirus/imunologia
Parechovirus/imunologia
Infecções por Picornaviridae/complicações
Infecções por Poxviridae/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Coinfecção/epidemiologia
Coinfecção/virologia
Europa (Continente)/epidemiologia
Feminino
Finlândia/epidemiologia
Hantavirus/isolamento & purificação
Febre Hemorrágica com Síndrome Renal/epidemiologia
Febre Hemorrágica com Síndrome Renal/imunologia
Febre Hemorrágica com Síndrome Renal/virologia
Seres Humanos
Coriomeningite Linfocítica/epidemiologia
Coriomeningite Linfocítica/imunologia
Coriomeningite Linfocítica/virologia
Masculino
Meia-Idade
Virus Puumala/isolamento & purificação
Soroconversão
Estudos Soroepidemiológicos
Zoonoses/epidemiologia
Zoonoses/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE



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