Base de dados : MEDLINE
Pesquisa : B04.280.650.160.650.150 [Categoria DeCS]
Referências encontradas : 316 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 32 ir para página                         

  1 / 316 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29323851
[Au] Autor:Borisevich SV; Marennikova SS; Stovba LF; Petrov AA; Krotvov VT; Makhlai AA
[Ti] Título:Buffalopox.
[So] Source:Vopr Virusol;61(5):200-4, 2016.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Buffalopox is a contagious viral disease affecting milch buffaloes (Bubalus Bubalis) and, rarely, cows. The disease has zoonotic implications, as outbreaks are frequently associated with human infections, particularly in the milkers. Buffalopox is associated with high morbidity (80%). The clinical symptoms of the disease are characterized by wartline lesions on the udder, teats, inguinal region, base of the ears, and over the parotid. In the severe form, generalized rash is observed. Although the disease does not lead to high mortality, it has an adverse effect on the productivity and working capacity of the animals resulting in large economic losses. The outbreaks of buffalopox occurred frequently in India, Pakistan, Bangladesh, Nepal, Iran, Egypt, and Indonesia, where buffaloes are reared as milch animals. The buffalopox is closely related with other Orthopoxviruses. In particular, it is close to the vaccinia virus. There is a view that the buffalopox virus might be derived from the vaccinia virus. It is possible that it became pathogenic to humans and animals through adaptive evolution of the genome by obtaining the virulence genes. PCR is performed for the C18L gene for the purpose of specific detection and differentiation of the buffalopox virus from other orthopoxviruses. The C18L gene encodes the ankyrin repeat protein, which determines the virus host range. The open reading frame of this gene is only 150-nucleotide long as against 453 nucleotide in the vaccinia virus, 756 - in the camelpox virus, and 759 - in the cowpox virus. It can be concluded that a systematic study based on the epidemiology of the virus, existence of reservoirs, biological transmission, and the molecular organization of the buffalopox virus from buffalo, cow, and humans may pave the way to a better understanding of the circulating virus and contribute to the control of the disease using the suitable diagnostic and prophylactic measures.
[Mh] Termos MeSH primário: Vírus da Varíola Bovina/genética
Varíola Bovina/epidemiologia
Surtos de Doenças
Vírus Vaccinia/genética
Vaccinia/veterinária
Zoonoses/epidemiologia
[Mh] Termos MeSH secundário: Animais
Repetição de Anquirina
Ásia Ocidental/epidemiologia
Búfalos/virologia
Bovinos
Varíola Bovina/transmissão
Varíola Bovina/virologia
Vírus da Varíola Bovina/classificação
Vírus da Varíola Bovina/isolamento & purificação
DNA Viral/genética
Oriente Médio/epidemiologia
Filogenia
Vaccinia/epidemiologia
Vaccinia/transmissão
Vaccinia/virologia
Vírus Vaccinia/classificação
Vírus Vaccinia/isolamento & purificação
Proteínas Virais/genética
Zoonoses/transmissão
Zoonoses/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (DNA, Viral); 0 (Viral Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  2 / 316 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29320650
[Au] Autor:Talarek E; Marczynska M
[Ad] Endereço:Medical University of Warsaw, Warsaw, Poland ewa.talarek@wum.edu.pl.
[Ti] Título:Cowpox Virus Infection.
[So] Source:N Engl J Med;378(2):181, 2018 Jan 11.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Vírus da Varíola Bovina/isolamento & purificação
Varíola Bovina/patologia
[Mh] Termos MeSH secundário: Animais
Gatos
Criança
Varíola Bovina/transmissão
Vírus da Varíola Bovina/genética
Face/patologia
Feminino
Seres Humanos
Reação em Cadeia da Polimerase
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1702548


  3 / 316 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28727764
[Au] Autor:Lorenzo MM; Sanchez-Puig JM; Blasco R
[Ad] Endereço:Departamento de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (I.N.I.A.), Madrid, Spain.
[Ti] Título:Vaccinia virus and Cowpox virus are not susceptible to the interferon-induced antiviral protein MxA.
[So] Source:PLoS One;12(7):e0181459, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:MxA protein is expressed in response to type I and type III Interferon and constitute an important antiviral factor with broad antiviral activity to diverse RNA viruses. In addition, some studies expand the range of MxA antiviral activity to include particular DNA viruses like Monkeypox virus (MPXV) and African Swine Fever virus (ASFV). However, a broad profile of activity of MxA to large DNA viruses has not been established to date. Here, we investigated if some well characterized DNA viruses belonging to the Poxviridae family are sensitive to human MxA. A cell line inducibly expressing MxA to inhibitory levels showed no anti-Vaccinia virus (VACV) virus activity, indicating either lack of susceptibility of the virus, or the existence of viral factors capable of counteracting MxA inhibition. To determine if VACV resistance to MxA was due to a virus-encoded anti-MxA activity, we performed coinfections of VACV and the MxA-sensitive Vesicular Stomatitis virus (VSV), and show that VACV does not protect VSV from MxA inhibition in trans. Those results were extended to several VACV strains and two CPXV strains, thus confirming that those Orthopoxviruses do not block MxA action. Overall, these results point to a lack of susceptibility of the Poxviridae to MxA antiviral activity.
[Mh] Termos MeSH primário: Vírus da Varíola Bovina/fisiologia
Proteínas de Resistência a Myxovirus/metabolismo
Vírus Vaccinia/fisiologia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Linhagem Celular
Cercopithecus aethiops
Coinfecção
Varíola Bovina/metabolismo
Citometria de Fluxo
Imunofluorescência
Seres Humanos
Microscopia de Fluorescência
Vaccinia/metabolismo
Estomatite Vesicular/metabolismo
Vesiculovirus
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MX1 protein, human); 0 (Myxovirus Resistance Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181459


  4 / 316 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28615415
[Au] Autor:Uhrlaub JL; Smithey MJ; Nikolich-Zugich J
[Ad] Endereço:Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724.
[Ti] Título:Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses.
[So] Source:J Immunol;199(2):403-407, 2017 Jul 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The vertebrate immune system uses multiple, sometimes redundant, mechanisms to contain pathogenic microorganisms that are always evolving to evade host defenses. Thus, the cowpox virus (CPXV) uses genes encoding CPXV12 and CPXV203 to prevent direct MHC class I presentation of viral peptides by infected cells. However, CD8 T cells are effectively primed against CPXV by cross-presentation of viral Ags in young mice. Old mice accumulate defects in both CD8 T cell activation and cross-presentation. Using a double-deletion mutant (∆12∆203) of CPXV, we show that direct priming of CD8 T cells in old mice yields superior recall responses, establishing a key contribution of this mechanism to host antipoxvirus responses and enhancing our fundamental understanding of how viral manipulation of direct presentation impacts pathogenesis. This also provides a proof of principle that suboptimal CD8 T cell in old organisms can be optimized by manipulating Ag presentation, with implications for vaccine design.
[Mh] Termos MeSH primário: Envelhecimento/imunologia
Apresentação do Antígeno
Linfócitos T CD8-Positivos/imunologia
[Mh] Termos MeSH secundário: Animais
Antígenos Virais/imunologia
Vírus da Varíola Bovina/genética
Vírus da Varíola Bovina/imunologia
Vírus da Varíola Bovina/patogenicidade
Apresentação Cruzada
Antígenos de Histocompatibilidade Classe I/imunologia
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos C57BL
Proteínas Virais/genética
Proteínas Virais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Viral); 0 (Histocompatibility Antigens Class I); 0 (Viral Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700625


  5 / 316 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27917750
[Au] Autor:Popova AY; Maksyutov RA; Taranov OS; Tregubchak TV; Zaikovskaya AV; Sergeev AA; Vlashchenko IV; Bodnev SA; Ternovoi VA; Alexandrova NS; Tarasov AL; Konovalova NV; Koroleva AA; Bulychev LE; Pyankov OV; Demina YV; Agafonov AP; Shchelkunov SN; Miheev VN
[Ad] Endereço:Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-being,Moscow,Russia.
[Ti] Título:Cowpox in a human, Russia, 2015.
[So] Source:Epidemiol Infect;145(4):755-759, 2017 Mar.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We investigated the first laboratory-confirmed human case of cowpox virus infection in Russia since 1991. Phylogenetic studies of haemagglutinin, TNF-α receptor-like protein and thymidine kinase regions showed significant differences with known orthopoxviruses, including unique amino-acid substitutions and deletions. The described cowpox virus strain, taking into account differences, is genetically closely related to strains isolated years ago in the same geographical region (European part of Russia and Finland), which suggests circulation of viral strains with common origin in wild rodents without spread over long distances and appearance in other parts of the world.
[Mh] Termos MeSH primário: Vírus da Varíola Bovina/isolamento & purificação
Varíola Bovina/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Vírus da Varíola Bovina/classificação
Vírus da Varíola Bovina/genética
Seres Humanos
Masculino
Filogenia
Federação Russa
Análise de Sequência de DNA
Homologia de Sequência
Proteínas Virais/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268816002922


  6 / 316 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27768891
[Au] Autor:Gilchuk I; Gilchuk P; Sapparapu G; Lampley R; Singh V; Kose N; Blum DL; Hughes LJ; Satheshkumar PS; Townsend MB; Kondas AV; Reed Z; Weiner Z; Olson VA; Hammarlund E; Raue HP; Slifka MK; Slaughter JC; Graham BS; Edwards KM; Eisenberg RJ; Cohen GH; Joyce S; Crowe JE
[Ad] Endereço:The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
[Ti] Título:Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections.
[So] Source:Cell;167(3):684-694.e9, 2016 Oct 20.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Monkeypox (MPXV) and cowpox (CPXV) are emerging agents that cause severe human infections on an intermittent basis, and variola virus (VARV) has potential for use as an agent of bioterror. Vaccinia immune globulin (VIG) has been used therapeutically to treat severe orthopoxvirus infections but is in short supply. We generated a large panel of orthopoxvirus-specific human monoclonal antibodies (Abs) from immune subjects to investigate the molecular basis of broadly neutralizing antibody responses for diverse orthopoxviruses. Detailed analysis revealed the principal neutralizing antibody specificities that are cross-reactive for VACV, CPXV, MPXV, and VARV and that are determinants of protection in murine challenge models. Optimal protection following respiratory or systemic infection required a mixture of Abs that targeted several membrane proteins, including proteins on enveloped and mature virion forms of virus. This work reveals orthopoxvirus targets for human Abs that mediate cross-protective immunity and identifies new candidate Ab therapeutic mixtures to replace VIG.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/imunologia
Anticorpos Neutralizantes/imunologia
Anticorpos Antivirais/imunologia
Especificidade de Anticorpos
Infecções por Poxviridae/imunologia
[Mh] Termos MeSH secundário: Varíola Bovina/imunologia
Vírus da Varíola Bovina/imunologia
Reações Cruzadas
Seres Humanos
Leucócitos Mononucleares/imunologia
Monkeypox/imunologia
Vírus da Varíola dos Macacos/imunologia
Varíola/imunologia
Vaccinia/imunologia
Vírus Vaccinia/imunologia
Vírus da Varíola/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antibodies, Neutralizing); 0 (Antibodies, Viral)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE


  7 / 316 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27291992
[Au] Autor:Tamosiunaite A; Hoffmann D; Franke A; Schluckebier J; Tauscher K; Tischer BK; Beer M; Klopfleisch R; Osterrieder N
[Ad] Endereço:Institut für Virologie, Freie Universität Berlin, Zentrum für Infektionsmedizin, Berlin, Germany.
[Ti] Título:Histopathological and Immunohistochemical Studies of Cowpox Virus Replication in a Three-Dimensional Skin Model.
[So] Source:J Comp Pathol;155(1):55-61, 2016 Jul.
[Is] ISSN:1532-3129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human cowpox virus (CPXV) infections are rare, but can result in severe and sometimes fatal outcomes. The majority of recent cases were traced back to contacts with infected domestic cats or pet rats. The aim of the present study was to evaluate a three-dimensional (3D) skin model as a possible replacement for animal experiments. We monitored CPXV lesion formation, viral gene expression and cell cycle patterns after infection of 3D skin cultures with two CPXV strains of different pathogenic potential: a recent pet rat isolate (RatPox09) and the reference Brighton red strain. Infected 3D skin cultures exhibited histological alterations that were similar to those of mammal skin infections, but there were no differences in gene expression patterns and tissue damage between the two CPXV strains in the model system. In conclusion, 3D skin cultures reflect the development of pox lesions in the skin very well, but seem not to allow differentiation between more or less virulent virus strains, a distinction that is made possible by experimental infection in suitable animal models.
[Mh] Termos MeSH primário: Vírus da Varíola Bovina/fisiologia
Técnicas de Cultura de Órgãos/métodos
Pele/virologia
[Mh] Termos MeSH secundário: Seres Humanos
Imuno-Histoquímica
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160614
[St] Status:MEDLINE


  8 / 316 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27166137
[Au] Autor:Johnson RF; Hammoud DA; Perry DL; Solomon J; Moore IN; Lackemeyer MG; Bohannon JK; Sayre PJ; Minai M; Papaneri AB; Hagen KR; Janosko KB; Jett C; Cooper K; Blaney JE; Jahrling PB
[Ad] Endereço:1​Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
[Ti] Título:Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease.
[So] Source:J Gen Virol;97(8):1942-54, 2016 Aug.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We previously demonstrated that small-particle (0.5-3.0 µm) aerosol infection of rhesus monkeys (Macaca mulatta) with cowpox virus (CPXV)-Brighton Red (BR) results in fulminant respiratory tract disease characterized by severe lung parenchymal pathology but only limited systemic virus dissemination and limited classic epidermal pox-like lesion development (Johnson et al., 2015). Based on these results, and to further develop CPXV as an improved model of human smallpox, we evaluated a novel large-particle aerosol (7.0-9.0 µm) exposure of rhesus monkeys to CPXV-BR and monitored for respiratory tract disease by serial computed tomography (CT). As expected, the upper respiratory tract and large airways were the major sites of virus-induced pathology following large-particle aerosol exposure. Large-particle aerosol CPXV exposure of rhesus macaques resulted in severe upper airway and large airway pathology with limited systemic dissemination.
[Mh] Termos MeSH primário: Aerossóis
Vírus da Varíola Bovina/patogenicidade
Varíola Bovina/patologia
Varíola Bovina/virologia
Modelos Animais de Doenças
Infecções Respiratórias/patologia
Infecções Respiratórias/virologia
[Mh] Termos MeSH secundário: Animais
Macaca mulatta
Infecções Respiratórias/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000501


  9 / 316 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27159333
[Au] Autor:Franke A; Kershaw O; Jenckel M; König L; Beer M; Hoffmann B; Hoffmann D
[Ad] Endereço:1 Institute of Diagnostic Virology , Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany .
[Ti] Título:Fatal Cowpox Virus Infection in an Aborted Foal.
[So] Source:Vector Borne Zoonotic Dis;16(6):431-3, 2016 Jun.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The article describes the isolation of a cowpox virus (CPXV) isolate originating from a horse. The skin of a foal, aborted in the third trimester, displayed numerous cutaneous papules. The histological examination showed A-type inclusion bodies within the lesion, typical for CPXV infections. This suspicion was confirmed by real-time PCR where various organs were analyzed. From skin samples, virus isolation was successfully performed. Afterwards, the whole genome of this new isolate "CPXV Amadeus" was sequenced by next-generation technology. Phylogenetic analysis clearly showed that "CPXV Amadeus" belongs to the "CPXV-like 1" clade. To our opinion, the study provides important additional information on rare accidental CPXV infections. From the natural hosts, the voles, species such as rats, cats, or different zoo animals are occasionally infected, but until now only two horse cases are described. In addition, there are new insights toward congenital CPXV infections.
[Mh] Termos MeSH primário: Aborto Animal
Vírus da Varíola Bovina/isolamento & purificação
Varíola Bovina/veterinária
Feto/virologia
Doenças dos Cavalos/virologia
[Mh] Termos MeSH secundário: Animais
Varíola Bovina/patologia
Varíola Bovina/virologia
Vírus da Varíola Bovina/genética
Evolução Fatal
Genoma Viral
Doenças dos Cavalos/patologia
Cavalos
Filogenia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160510
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2015.1932


  10 / 316 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26891134
[Au] Autor:Fassbender P; Zange S; Ibrahim S; Zoeller G; Herbstreit F; Meyer H
[Ti] Título:Generalized Cowpox Virus Infection in a Patient with HIV, Germany, 2012.
[So] Source:Emerg Infect Dis;22(3):553-5, 2016 Mar.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Coinfecção
Vírus da Varíola Bovina/classificação
Vírus da Varíola Bovina/genética
Varíola Bovina/diagnóstico
Varíola Bovina/virologia
Infecções por HIV/virologia
[Mh] Termos MeSH secundário: Biópsia
DNA Viral
Evolução Fatal
Alemanha
Infecções por HIV/diagnóstico
Seres Humanos
Masculino
Reação em Cadeia da Polimerase
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160219
[St] Status:MEDLINE
[do] DOI:10.3201/eid2203.151158



página 1 de 32 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde