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[PMID]: | 26307166 |
[Au] Autor: | Anthony SJ; St Leger JA; Liang E; Hicks AL; Sanchez-Leon MD; Jain K; Lefkowitch JH; Navarrete-Macias I; Knowles N; Goldstein T; Pugliares K; Ip HS; Rowles T; Lipkin WI |
[Ad] Endereço: | Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA EcoHealth Alliance, New York, New York, USA sja2127@cumc.columbia.edu. |
[Ti] Título: | Discovery of a Novel Hepatovirus (Phopivirus of Seals) Related to Human Hepatitis A Virus. |
[So] Source: | MBio;6(4), 2015 Aug 25. | [Is] ISSN: | 2150-7511 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | UNLABELLED: Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV. IMPORTANCE: Hepatitis A virus (HAV) is an important viral hepatitis in humans because of the substantial number of cases each year in regions with low socioeconomic status. The origin of HAV is unknown, and no nonprimate HAV-like viruses have been described. Here, we describe the discovery of an HAV-like virus in seals. This finding suggests that the diversity and evolutionary history of these viruses might be far greater than previously thought and may provide insight into the origin and pathogenicity of HAV. |
[Mh] Termos MeSH primário: |
Hepatovirus/genética Hepatovirus/isolamento & purificação Filogenia Focas Verdadeiras/virologia
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[Mh] Termos MeSH secundário: |
Animais Códon Genoma Viral Genótipo Vírus da Hepatite A Humana/genética Hepatovirus/fisiologia Sequenciamento de Nucleotídeos em Larga Escala Seres Humanos Fígado/virologia Pulmão/virologia RNA Viral/genética Reação em Cadeia da Polimerase em Tempo Real Baço/virologia Replicação Viral
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S. |
[Nm] Nome de substância:
| 0 (Codon); 0 (RNA, Viral) |
[Em] Mês de entrada: | 1606 |
[Cu] Atualização por classe: | 161019 |
[Lr] Data última revisão:
| 161019 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 150827 |
[St] Status: | MEDLINE |
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