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Pesquisa : B04.450.420.410 [Categoria DeCS]
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  1 / 1038 MEDLINE  
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[PMID]:28749336
[Au] Autor:Gozlan Y; Bar-Or I; Rakovsky A; Savion M; Amitai Z; Sheffer R; Ceder N; Anis E; Grotto I; Mendelson E; Mor O
[Ad] Endereço:Central Virology Laboratory, Ministry of Health, Sheba Medical Center, Ramat Gan.
[Ti] Título:Ongoing hepatitis A among men who have sex with men (MSM) linked to outbreaks in Europe in Tel Aviv area, Israel, December 2016 - June 2017.
[So] Source:Euro Surveill;22(29), 2017 Jul 20.
[Is] ISSN:1560-7917
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:Between December 2016 and June 2017, 19 Hepatitis A virus (HAV)-positive cases, 17 of which were among men who have sex with men (MSM) were identified in the Tel Aviv area. Seven of the 15 sewage samples collected between January and June 2017 were also HAV-positive. All sequences clustered with two of the three strains identified in the current European HAV outbreak. We demonstrate that despite an efficient vaccination programme, HAV can still be transmitted to an unvaccinated high-risk population.
[Mh] Termos MeSH primário: Surtos de Doenças
Vírus da Hepatite A/isolamento & purificação
Hepatite A/epidemiologia
Homossexualidade Masculina
[Mh] Termos MeSH secundário: Adulto
Hepatite A/diagnóstico
Vírus da Hepatite A/genética
Seres Humanos
Israel/epidemiologia
Masculino
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


  2 / 1038 MEDLINE  
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[PMID]:29364806
[Au] Autor:Branco JC; Alberto SF; Martins A
[Ad] Endereço:Serviço de Gastrenterologia. Hospital Professor Doutor Fernando Fonseca. Amadora. Portugal.
[Ti] Título:Letter to the Editor regarding the article "Prevalence of Hepatitis A Virus Antibody in Portuguese Travelers: A New Paradigm".
[So] Source:Acta Med Port;30(12):891-892, 2017 12 29.
[Is] ISSN:1646-0758
[Cp] País de publicação:Portugal
[La] Idioma:eng
[Mh] Termos MeSH primário: Hepatite B
Viagem
[Mh] Termos MeSH secundário: Vírus da Hepatite A
Seres Humanos
Prevalência
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.20344/amp.9632


  3 / 1038 MEDLINE  
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Vicente, Ana Carolina P
Texto completo SciELO Brasil
[PMID]:29211109
[Au] Autor:Conteville LC; Filippis AMB; Nogueira RMR; Mendonça MCL; Vicente ACP
[Ad] Endereço:Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Genética Molecular de Microrganismos, Rio de Janeiro, RJ, Brasil.
[Ti] Título:Metagenomic analysis reveals Hepatitis A virus in suspected yellow fever cases in Brazil.
[So] Source:Mem Inst Oswaldo Cruz;113(1):66-67, 2018 Jan.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Using a metagenomic approach, we identified hepatitis A virus among cases of acute febrile illnesses that occurred in 2008-2012 in Brazil suspected as yellow fever. These findings reinforce the challenge facing routine clinical diagnosis in complex epidemiological scenarios.
[Mh] Termos MeSH primário: Hepatite A/diagnóstico
Febre Amarela/diagnóstico
[Mh] Termos MeSH secundário: Brasil/epidemiologia
Genótipo
Hepatite A/epidemiologia
Vírus da Hepatite A/genética
Seres Humanos
Metagenômica
Febre Amarela/epidemiologia
Vírus da Febre Amarela/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  4 / 1038 MEDLINE  
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[PMID]:29036227
[Au] Autor:Lee YL; Lin KY; Cheng CY; Li CW; Yang CJ; Tsai MS; Tang HJ; Lin TY; Wang NC; Lee YC; Lin SP; Huang YS; Sun HY; Zhang JY; Ko WC; Cheng SH; Lee YT; Liu CE; Hung CC; Taiwan HIV Study Group
[Ad] Endereço:Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
[Ti] Título:Evolution of hepatitis A virus seroprevalence among HIV-positive adults in Taiwan.
[So] Source:PLoS One;12(10):e0186338, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The study aimed to describe the seroprevalence of hepatitis A virus (HAV) in HIV-positive adult patients in Taiwan between 2012 and 2016 and to examine the evolution of HAV seroprevalence between 2004-2007 and 2012-2016. METHODS: Clinical information and data of anti-HAV antibody results were collected from 2,860 antiretroviral-naïve HIV-positive Taiwanese aged 18 years or older who initiated combination antiretroviral therapy at 11 hospitals around Taiwan between 2012 and 2016 (2012-2016 cohort). A multivariate logistic regression model was applied to identify independent variables associated with HAV seropositivity. Comparisons of HAV seroprevalences and associated clinical characteristics were made between this 2012-2016 cohort and a previous cohort of 1580 HIV-positive patients in 2004-2007 (2004-2007 cohort). RESULTS: Of the 2,860 HIV-positive patients between 2012 and 2016, the overall HAV seropositivity rate was 21.2% (605/2860), which was independently associated with an older age (adjusted odds ratio [AOR], per 1-year increase, 1.13; 95% confidence interval [95% CI], 1.11-1.15) and co-infection with hepatitis B virus (AOR 1.44; 95% CI, 1.08-1.93). Residence in southern Taiwan (AOR 0.49; 95% CI, 0.34-0.72) was inversely associated with HAV seropositivity. The overall HAV seroprevalence in the 2012-2016 cohort was significantly lower than that in the 2004-2007 cohort (21.2% vs 60.9%, p<0.01). The decreases of HAV seropositivity rate were observed in nearly every age-matched group, which suggested the cohort effect on HAV seroepidemiology. However, among individuals aged 25 years or younger, the HAV seropositivity rate increased from 3.8% (2/52) in the 2004-2007 cohort to 8.5% (50/587) in the 2012-2016 cohort, with 95.4% (560/587) being MSM in this age group of the latter cohort. CONCLUSIONS: HAV seroprevalence has decreased with time among HIV-positive adults in Taiwan. The cohort effect has increased the number of young HIV-positive patients that are susceptible to HAV infection in a country without nationwide childhood vaccination program against HAV.
[Mh] Termos MeSH primário: Infecções por HIV/sangue
Infecções por HIV/imunologia
Anticorpos Anti-Hepatite A/sangue
Vírus da Hepatite A/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Fármacos Anti-HIV/uso terapêutico
Feminino
Infecções por HIV/tratamento farmacológico
Infecções por HIV/epidemiologia
Hepatite A/prevenção & controle
Vacinas contra Hepatite A/administração & dosagem
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Estudos Retrospectivos
Estudos Soroepidemiológicos
Taiwan/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Hepatitis A Antibodies); 0 (Hepatitis A Vaccines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186338


  5 / 1038 MEDLINE  
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[PMID]:28858094
[Au] Autor:Yoshida Y; Okada Y; Suzuki A; Kakisaka K; Miyamoto Y; Miyasaka A; Takikawa Y; Nishizawa T; Okamoto H
[Ad] Endereço:aDivision of Hepatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Iwate bDivision of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimozuke, Tochigi, Japan.
[Ti] Título:Fatal acute hepatic failure in a family infected with the hepatitis A virus subgenotype IB: A case report.
[So] Source:Medicine (Baltimore);96(35):e7847, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Hepatitis A viral infection is a well-known cause of subclinical or acute self-limited hepatitis. Few cases of hepatitis A virus (HAV)-associated acute liver failure (ALF) have been reported in low HAV endemic countries annually. PATIENTS CONCERNS: To investigate the possible factors that affected the severity of HAV infection, a family cluster infected with the HAV subgenotype IB strain, which is not common in Japan, was described. DIAGNOSES: This family consisted of five members who all were infected with HAV. INTERVENTIONS: Four of the five patients hospitalized except for an asymptomatic patient. OUTCOMES: Two of the five patients, men in their 50s and 60s, developed ALF, and one patient died. Various host factors, including sex (male), age, and a high bilirubin level, may affect the outcomes. Based on viral factors, HAV RNA was higher in the fatal case compared with others, and it decreased within a short period of time. The similarity of the nucleotide sequences was 99.9% among the HAV isolates based on an entire genomic sequence. Deletions and/or insertions on the HAV protein-coding sequences that caused a frameshift were found in surviving cases but not in the fatal case. LESSONS: The rapid clearance of increased HAV and the absence of defective HAV might be closely associated with the onset of liver failure.
[Mh] Termos MeSH primário: Família
Hepatite A/diagnóstico
Falência Hepática Aguda/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Evolução Fatal
Feminino
Hepatite A/complicações
Hepatite A/virologia
Vírus da Hepatite A/isolamento & purificação
Seres Humanos
Japão
Falência Hepática Aguda/complicações
Falência Hepática Aguda/virologia
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007847


  6 / 1038 MEDLINE  
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[PMID]:28800730
[Au] Autor:Yilmaz H; Karakullukcu A; Turan N; Cizmecigil UY; Yilmaz A; Ozkul AA; Aydin O; Gunduz A; Mete M; Zeyrek FY; Kirazoglu TT; Richt JA; Kocazeybek B
[Ad] Endereço:Department of Virology, Veterinary Faculty, University of Istanbul, Avcilar, Istanbul, Turkey. hyilmaz@istanbul.edu.tr.
[Ti] Título:Genotypes of hepatitis a virus in Turkey: first report and clinical profile of children infected with sub-genotypes IA and IIIA.
[So] Source:BMC Infect Dis;17(1):561, 2017 Aug 11.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hepatitis A virus (HAV) is a food and water-borne virus causing clinical (mainly hepatitis) and subclinical disease in humans. It is important to characterize circulating strains of HAV in order to prevent HAV infections using efficacious vaccines. The aim of this study was the detection and characterization of the circulating strains of HAV in Turkey by performing serology, RT-PCR, sequencing and phylogenetic analysis. METHODS: In this study, 355 HAV suspected cases were analysed by ELISA for the presence of antibodies to HAV. RNA was extracted from 54 HAV IgM positive human sera. None of the suspect cases were vaccinated against HAV and they never received blood transfusions. Samples found positive by RT-PCR using primers targeting the VP1/VP2A junction and VP1/VP3 capsid region of HAV, were subjected to sequencing and phylogenetic analyses. RESULTS: IgM type antibodies to HAV were detected in 54 patients. Twenty one of them were students. The age of IgM positive cases was between 3 and 60 years. IgM positivity differed in age groups and was higher in the age group 3 to 10 years. Phylogenetic analysis showed that the majority of HAV strains detected in this study belong to the "HAV 1B" cluster. In addition, the HAV sub-genotypes IA (KT874461.1) and IIIA (KT222963.1) were found in 2 children. These sub-genotypes were not previously reported in Turkey. The child who carried sub-genotype IIIA travelled to Afghanistan and presented with abdominal pain, icterus and vomitus. He was positive for anti-HAV IgM and IgG but negative for hepatitis B and C. Liver enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase and lactate dehydrogenase were severely elevated. Bilirubin levels were also increased. White blood cells, neutrophils and hemoglobin were decreased while lymphocytes and monocytes were increased. Similar clinical signs and laboratory findings were reported for the child infected with sub-genotype IA but aspartate aminotransferase and alanine aminotransferase were not severely elevated. CONCLUSIONS: The results indicate that molecular studies determining the HAV genotype variation in Turkey are timely and warranted. The majority of IgM positive cases in 3-10 year old patients indicate that childhood vaccination is important. Sub-genotype IB is the most prevalant genotype in Turkey. Surprisingly, sub-genotype IA and IIIA are also present in Turkey; future diagnostic efforts need to include diagnostic methods which can identify this emerging HAV genotypes. Our results also show that one important risk factor for contracting hepatitis A virus is international travel since genotype IIIA was detected in a child who had travelled to Afghanistan.
[Mh] Termos MeSH primário: Vírus da Hepatite A/genética
Hepatite A/etiologia
Filogenia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Afeganistão
Criança
Pré-Escolar
Feminino
Genótipo
Hepatite A/virologia
Anticorpos Anti-Hepatite A/sangue
Vírus da Hepatite A/isolamento & purificação
Vírus da Hepatite A/patogenicidade
Seres Humanos
Fígado/enzimologia
Fígado/virologia
Masculino
Meia-Idade
Turquia
Proteínas Estruturais Virais/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hepatitis A Antibodies); 0 (VP1 protein, hepatitis A virus); 0 (Viral Structural Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2667-3


  7 / 1038 MEDLINE  
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[PMID]:28737126
[Au] Autor:Jacob L; Kostev K
[Ti] Título:Compliance with vaccination against hepatitis A virus in Germany: A retrospective analysis
.
[So] Source:Int J Clin Pharmacol Ther;55(9):740-745, 2017 Sep.
[Is] ISSN:0946-1965
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To analyze compliance with vaccination against hepatitis A virus (HAV) in patients followed in general and pediatric practices in Germany. MATERIALS AND METHODS: The present study included 7,323 patients from 575 general practices and 3,962 patients from 111 pediatric practices. Patients were included if they had received the first dose of one of the two following vaccines against HAV: Havrix® or Vaqta®, between 2011 and 2014. The immunization schedule of these vaccines consisted of two injections. Patients were considered compliant if they received the second dose at the recommended time or within a period of ± 25% around the recommended time (tolerance period). RESULTS: Of the recruited patients, 61.1% received the second vaccine injection within the tolerance period. Individuals treated in pediatric practices had a higher likelihood of receiving the vaccine dose within the tolerance period compared to individuals treated in general practices (OR = 1.19; 95% CI: 1.06 - 1.35; p = 0.005). Furthermore, patients under the age of 18 years were more likely to be compliant than patients over the age of 30 years (OR = 1.53; 95% CI: 1.40 - 1.68; p < 0.001), while patients between 18 and 30 years (OR = 0.85; 95% CI: 0.77 - 0.93; p < 0.001) were the least likely to be compliant. CONCLUSION: Compliance with complete vaccination against HAV was low.
.
[Mh] Termos MeSH primário: Vírus da Hepatite A/imunologia
Vacinas/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Alemanha
Seres Humanos
Esquemas de Imunização
Masculino
Estudos Retrospectivos
Vacinação/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vaccines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.5414/CP202990


  8 / 1038 MEDLINE  
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[PMID]:28705178
[Au] Autor:Bruni R; Taffon S; Equestre M; Cella E; Lo Presti A; Costantino A; Chionne P; Madonna E; Golkocheva-Markova E; Bankova D; Ciccozzi M; Teoharov P; Ciccaglione AR
[Ad] Endereço:National Reference Laboratory for HAV, Viral Hepatitis Unit, Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy. roberto.bruni@iss.it.
[Ti] Título:Hepatitis a virus genotypes and strains from an endemic area of Europe, Bulgaria 2012-2014.
[So] Source:BMC Infect Dis;17(1):497, 2017 Jul 14.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hepatitis A virus (HAV) infection is endemic in Eastern European and Balkan region countries. In 2012, Bulgaria showed the highest rate (67.13 cases per 100,000) in Europe. Nevertheless, HAV genotypes and strains circulating in this country have never been described. The present study reports the molecular characterization of HAV from 105 patients from Bulgaria. METHODS: Anti-HAV IgM positive serum samples collected in 2012-2014 from different towns and villages in Bulgaria were analysed by nested RT-PCR, sequencing of the VP1/2A region and phylogenetic analysis; the results were analysed together with patient and geographical data. RESULTS: Phylogenetic analysis revealed two main sequence groups corresponding to the IA (78/105, 74%) and IB (27/105, 26%) sub-genotypes. In the IA group, a major and a minor cluster were observed (62 and 16 sequences, respectively). Most sequences from the major cluster (44/62, 71%) belonged to either of two strains, termed "strain 1" and "strain 2", differing only for a single specific nucleotide; the remaining sequences (18/62, 29%) showed few (1 to 4) nucleotide variations respect to strain 1 and 2. Strain 2 is identical to the strain previously responsible for an outbreak in the Czech Republic in 2008 and a large multi-country European outbreak caused by contaminated mixed frozen berries in 2013. Most sequences of the IA minor cluster and the IB group were detected in large/medium centers (LMCs). Overall, sequences from the IA major cluster were more frequent in small centers (SCs), but strain 1 and strain 2 showed an opposite relative frequency in SCs and LMCs (strain 1 more frequent in SCs, strain 2 in LMCs). CONCLUSIONS: Genotype IA predominated in Bulgaria in 2012-2014 and phylogenetic analysis identified a major cluster of highly related or identical IA sequences, representing 59% of the analysed cases; these isolates were mostly detected in SCs, in which HAV shows higher endemicity than in LMCs. The distribution of viral sequences suggests the existence of some differences between the transmission routes in SCs and LMCs. Molecular characterization of an increased number of isolates from Bulgaria, regularly collected over time, will be useful to explore specific transmission routes and plan appropriate preventing measures.
[Mh] Termos MeSH primário: Vírus da Hepatite A/genética
Hepatite A/virologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Bulgária/epidemiologia
Criança
Pré-Escolar
República Tcheca/epidemiologia
Surtos de Doenças
Feminino
Genótipo
Hepatite A/epidemiologia
Anticorpos Anti-Hepatite A/sangue
Vírus da Hepatite A/isolamento & purificação
Seres Humanos
Lactente
Recém-Nascido
Masculino
Filogenia
Reação em Cadeia da Polimerase
População Urbana
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hepatitis A Antibodies)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2596-1


  9 / 1038 MEDLINE  
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[PMID]:28604562
[Au] Autor:Realpe-Quintero M; Copado-Villagrana ED; Trujillo-Ochoa JL; Alvarez AH; Panduro A; Fierro NA
[Ad] Endereço:From the *Departamento de Medicina Veterinaria, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, †Unidad de Inmunovirología, Servicio de Biología Molecular en Medicina, Hospital Civil de Guadalajara "Fray Antonio Alcalde," ‡Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, §Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, A.C., Biotecnología Biomédica, ¶Servicio de Biología Molecular en Medicina, Hospital Civil of Guadalajara "Fray Antonio Alcalde," and ‖Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
[Ti] Título:Cytokine Signatures Discriminate Highly Frequent Acute Hepatitis a Virus and Hepatitis E Virus Coinfections from Monoinfections in Mexican Pediatric Patients.
[So] Source:Pediatr Infect Dis J;36(7):689-692, 2017 Jul.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The frequency of hepatitis A virus and hepatitis E virus infections and their cytokine profiles were analyzed in Mexican pediatric patients with acute hepatitis. A high frequency of coinfections was found. Significant overexpression of interleukin (IL)-4, IL-12, IL-13 and interferon-gamma during hepatitis A virus monoinfections and limited secretion of cytokines in hepatitis E virus infections were observed.
[Mh] Termos MeSH primário: Coinfecção/imunologia
Citocinas/sangue
Hepatite A/complicações
Hepatite A/imunologia
Hepatite E/complicações
Hepatite E/imunologia
[Mh] Termos MeSH secundário: Doença Aguda/epidemiologia
Adolescente
Criança
Pré-Escolar
Coinfecção/epidemiologia
Coinfecção/virologia
Hepatite A/epidemiologia
Hepatite A/virologia
Vírus da Hepatite A/imunologia
Anticorpos Anti-Hepatite/sangue
Hepatite E/epidemiologia
Hepatite E/virologia
Vírus da Hepatite E/imunologia
Seres Humanos
Lactente
Recém-Nascido
México/epidemiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Hepatitis Antibodies)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001556


  10 / 1038 MEDLINE  
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[PMID]:28576363
[Au] Autor:Randazzo W; Falcó I; Aznar R; Sánchez G
[Ad] Endereço:Department of Microbiology and Ecology, University of Valencia Av. Dr. Moliner, 50. 46100 Burjassot, Valencia, Spain.
[Ti] Título:Effect of green tea extract on enteric viruses and its application as natural sanitizer.
[So] Source:Food Microbiol;66:150-156, 2017 Sep.
[Is] ISSN:1095-9998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this work, the effect of green tea extract (GTE) was assessed against murine norovirus (MNV) and hepatitis A virus (HAV) at different temperatures, exposure times and pH conditions. Initially, GTE at 0.5 and 5 mg/ml were individually mixed with each virus at 5 log TCID /ml and incubated 2 h at 37 °C at different pHs (from 5.5 to 8.5). GTE affected both viruses depending on pH with higher reductions observed in alkaline conditions. Secondly, different concentrations of GTE (0.5 and 5 mg/ml) were mixed with viral suspensions and incubated for 2 or 16 h at 4, 25 and 37 °C at pH 7.2. A concentration-, temperature- and exposure time-dependent response was showed by GTE in suspension tests, where complete inactivation was achieved after overnight exposure at 37 °C for both viruses and also at 25 °C for HAV. In addition, antiviral effect of GTE proved efficient in the surface disinfection tests since 1.5 log reduction and complete inactivation were recorded for MNV and HAV on stainless steel and glass surfaces treated with 10 mg/ml GTE for 30 min, analyzed in accordance with ISO 13697:2001. GTE was also evaluated as a natural disinfectant of produce, showing 10 mg/ml GTE reduced MNV and HAV titers in lettuce and spinach by more than 1.5 log after 30 min treatment. The results show a potential of GTE as natural disinfectant able to limit enteric viral (cross-)contaminations conveyed by food and food-contact surfaces.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Camellia sinensis/química
Desinfetantes/farmacologia
Vírus da Hepatite A/efeitos dos fármacos
Norovirus/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Vírus da Hepatite A/fisiologia
Alface/virologia
Norovirus/fisiologia
Aço Inoxidável/análise
Inativação de Vírus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Disinfectants); 0 (Plant Extracts); 12597-68-1 (Stainless Steel)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE



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