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  1 / 2802 MEDLINE  
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[PMID]:28615198
[Au] Autor:Meissner ME; Mendonça LM; Zhang W; Mansky LM
[Ad] Endereço:Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
[Ti] Título:Polymorphic Nature of Human T-Cell Leukemia Virus Type 1 Particle Cores as Revealed through Characterization of a Chronically Infected Cell Line.
[So] Source:J Virol;91(16), 2017 Aug 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 cell-to-cell transmission is dependent on the release of infectious virus particles into the virological synapse. The HTLV-1 particle structure is still poorly understood, and previous studies analyzed viruses produced by transformed lymphocytic cell lines chronically infected with HTLV-1, particularly the MT-2 cell line, which harbors truncated proviruses and expresses aberrant forms of the Gag protein. In this study, we demonstrate that the chronically infected SP cell line harbors a relatively low number of proviruses, making it a more promising experimental system for the study of the HTLV-1 particle structure. We first identified the genomic sites of integration and characterized the genetic structure of the region in each provirus. We also determined that despite encoding a truncated Gag protein, only the full-length Gag protein was incorporated into virus particles. Cryo-transmission electron microscopy analyses of the purified virus particles revealed three classes of particles based upon capsid core morphology: complete cores, incomplete cores, and particles without distinct electron densities that would correlate with the capsid region of a core structure. Observed cores were generally polygonal, and virus particles were on average 115 nm in diameter. These data corroborate particle morphologies previously observed for MT-2 cells and provide evidence that the known poor infectivity of HTLV-1 particles may correlate with HTLV-1 particle populations containing few virus particles possessing a complete capsid core structure. Studies of retroviral particle core morphology have demonstrated a correlation between capsid core stability and the relative infectivity of the virus. In this study, we used cryo-transmission electron microscopy to demonstrate that HTLV-1 particles produced from a distinct chronically infected cell line are polymorphic in nature, with many particles lacking organized electron densities that would correlate with a complete core structure. These findings have important implications for infectious HTLV-1 spread, particularly in the context of cell-to-cell transmission, a critical step in HTLV-1 transmission and pathogenesis.
[Mh] Termos MeSH primário: Deltaretrovirus/fisiologia
Deltaretrovirus/ultraestrutura
Provírus/genética
Vírion/ultraestrutura
Integração Viral
[Mh] Termos MeSH secundário: Linhagem Celular
Microscopia Crioeletrônica
Deltaretrovirus/genética
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE


  2 / 2802 MEDLINE  
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[PMID]:26657642
[Au] Autor:Maertens GN
[Ad] Endereço:Division of Infectious Diseases, St. Mary's campus, Imperial College London, Norfolk Place, London, W2 1PG, UK g.maertens@imperial.ac.uk.
[Ti] Título:B'-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase.
[So] Source:Nucleic Acids Res;44(1):364-76, 2016 Jan 08.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To establish infection, a retrovirus must insert a DNA copy of its RNA genome into host chromatin. This reaction is catalysed by the virally encoded enzyme integrase (IN) and is facilitated by viral genus-specific host factors. Herein, cellular serine/threonine protein phosphatase 2A (PP2A) is identified as a functional IN binding partner exclusive to δ-retroviruses, including human T cell lymphotropic virus type 1 and 2 (HTLV-1 and HTLV-2) and bovine leukaemia virus (BLV). PP2A is a heterotrimer composed of a scaffold, catalytic and one of any of four families of regulatory subunits, and the interaction is specific to the B' family of the regulatory subunits. B'-PP2A and HTLV-1 IN display nuclear co-localization, and the B' subunit stimulates concerted strand transfer activity of δ-retroviral INs in vitro. The protein-protein interaction interface maps to a patch of highly conserved residues on B', which when mutated render B' incapable of binding to and stimulating HTLV-1 and -2 IN strand transfer activity.
[Mh] Termos MeSH primário: Deltaretrovirus/metabolismo
Integrases/metabolismo
Proteína Fosfatase 2/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Proteínas de Transporte/metabolismo
Bovinos
Linhagem Celular
Deltaretrovirus/enzimologia
Ativação Enzimática
Vírus 1 Linfotrópico T Humano/enzimologia
Vírus 1 Linfotrópico T Humano/metabolismo
Seres Humanos
Vírus da Leucemia Bovina/enzimologia
Vírus da Leucemia Bovina/metabolismo
Modelos Moleculares
Dados de Sequência Molecular
Ligação Proteica
Conformação Proteica
Domínios e Motivos de Interação entre Proteínas
Mapeamento de Interação de Proteínas
Proteína Fosfatase 2/química
Subunidades Proteicas
Alinhamento de Sequência
Integração Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Protein Subunits); EC 2.7.7.- (Integrases); EC 3.1.3.16 (Protein Phosphatase 2)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkv1347


  3 / 2802 MEDLINE  
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[PMID]:26546777
[Au] Autor:de Sá KS; Santana BB; de Souza Ferreira TC; Sousa RC; Caldas CA; Azevedo VN; Feitosa RN; Machado LF; de Oliveira Guimarães Ishak M; Ishak R; Vallinoto AC
[Ad] Endereço:Laboratory of Virology (Laboratório de Virologia), Institute of Biological Sciences (Instituto de Ciências Biológicas), Federal University of Pará (Universidade Federal do Pará), Guamá, 66075-110 Belém, Pará, Brazil.
[Ti] Título:IL28B gene polymorphisms and Th1/Th2 cytokine levels might be associated with HTLV-associated arthropathy.
[So] Source:Cytokine;77:79-87, 2016 Jan.
[Is] ISSN:1096-0023
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study is the first investigation of the association between single nucleotide polymorphisms (SNPs - rs8099917, rs12979860 and rs8103142) of the IL28B gene and the development of human T-lymphotropic virus (HTLV)-associated arthropathy (HAA). Individuals with HAA exhibited low interleukin (IL) 6 (p<0.05) and high IL-10 (p<0.05) levels compared with asymptomatic patients. TNF-α/CD4(+) T cell count, TNF-α/CD8(+) T cell count and IFN-γ/proviral load positively correlated in asymptomatic patients. The allelic and genotypic frequencies did not differ between patients with HAA and asymptomatic patients. Seven haplotypes were detected in the investigated population, with haplotype CCT (p<0.05) being the most frequent among the HTLV-infected individuals, while haplotype TTG (p<0.05) was detected in the group with HAA only. Compared with asymptomatic patients, individuals with HAA and genotype TT (rs8099917) exhibited larger numbers of CD8(+) T cells (p<0.05) and higher proviral load levels (p<0.05). Those patients with HAA and genotypes CC (rs12979860) and TT (rs8103142) exhibited high TNF-ß (p<0.05) and IFN-γ (p<0.05) levels. Those patients with HAA and genotype CT/TT (rs12979860) exhibited high IL-10 levels (p<0.05). These results suggest that haplotypes CCT and TTG might be associated with susceptibility to HTLV infection and progression to HAA, respectively. Genotype TT (rs8099917) might be a risk factor for elevation of the proviral load and CD8(+) T cell count. In addition, genotypes CC (rs12979860) and TT (rs8103142) seem to be associated with increased TNF-ß and IFN-γ levels.
[Mh] Termos MeSH primário: Artrite Infecciosa/virologia
Citocinas/metabolismo
Infecções por Deltaretrovirus/virologia
Deltaretrovirus/fisiologia
Interleucinas/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Alelos
Artrite Infecciosa/genética
Artrite Infecciosa/metabolismo
Linfócitos T CD4-Positivos/metabolismo
Linfócitos T CD8-Positivos/metabolismo
Infecções por Deltaretrovirus/genética
Infecções por Deltaretrovirus/metabolismo
Feminino
Frequência do Gene
Genótipo
Haplótipos
Interações Hospedeiro-Patógeno
Seres Humanos
Interferon gama/metabolismo
Interleucina-10/metabolismo
Interleucina-6/metabolismo
Contagem de Linfócitos
Masculino
Células Th1/metabolismo
Células Th2/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (IL28B protein, human); 0 (Interleukin-6); 0 (Interleukins); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151130
[Lr] Data última revisão:
151130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151108
[St] Status:MEDLINE


  4 / 2802 MEDLINE  
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[PMID]:26262414
[Au] Autor:Cardoso Coelho K; Barcellos Almeida M
[Ad] Endereço:Federal University of Minas Gerais, Belo Horizonte, Brazil.
[Ti] Título:Representation of Biomedical Expertise in Ontologies: a Case Study about Knowledge Acquisition on HTLV viruses and their clinical manifestations.
[So] Source:Stud Health Technol Inform;216:1115, 2015.
[Is] ISSN:0926-9630
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this paper, we introduce a set of methodological steps for knowledge acquisition applied to the organization of biomedical information through ontologies. Those steps are tested in a real case involving Human T Cell Lymphotropic Virus (HTLV), which causes myriad infectious diseases. We hope to contribute to providing suitable knowledge representation of scientific domains.
[Mh] Termos MeSH primário: Infecções por Deltaretrovirus/classificação
Deltaretrovirus/classificação
Processamento de Linguagem Natural
Publicações Periódicas como Assunto
Vocabulário Controlado
[Mh] Termos MeSH secundário: Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Estudos de Casos Organizacionais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150812
[Lr] Data última revisão:
150812
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:150812
[St] Status:MEDLINE


  5 / 2802 MEDLINE  
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[PMID]:25620466
[Au] Autor:Mei S; Zhu H
[Ad] Endereço:1] Software College, Shenyang Normal University, Shenyang, 110034, China [2] Bioinformatics Section, School of Biomedical Sciences, Southern Medical University, Guangzhou, 510515, China.
[Ti] Título:A novel one-class SVM based negative data sampling method for reconstructing proteome-wide HTLV-human protein interaction networks.
[So] Source:Sci Rep;5:8034, 2015 Jan 26.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Protein-protein interaction (PPI) prediction is generally treated as a problem of binary classification wherein negative data sampling is still an open problem to be addressed. The commonly used random sampling is prone to yield less representative negative data with considerable false negatives. Meanwhile rational constraints are seldom exerted on model selection to reduce the risk of false positive predictions for most of the existing computational methods. In this work, we propose a novel negative data sampling method based on one-class SVM (support vector machine, SVM) to predict proteome-wide protein interactions between HTLV retrovirus and Homo sapiens, wherein one-class SVM is used to choose reliable and representative negative data, and two-class SVM is used to yield proteome-wide outcomes as predictive feedback for rational model selection. Computational results suggest that one-class SVM is more suited to be used as negative data sampling method than two-class PPI predictor, and the predictive feedback constrained model selection helps to yield a rational predictive model that reduces the risk of false positive predictions. Some predictions have been validated by the recent literature. Lastly, gene ontology based clustering of the predicted PPI networks is conducted to provide valuable cues for the pathogenesis of HTLV retrovirus.
[Mh] Termos MeSH primário: Deltaretrovirus/genética
Mapas de Interação de Proteínas/genética
Proteínas/genética
Proteoma/genética
[Mh] Termos MeSH secundário: Algoritmos
Biologia Computacional
Bases de Dados de Proteínas
Ontologia Genética
Seres Humanos
Máquina de Vetores de Suporte
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Proteins); 0 (Proteome)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150127
[St] Status:MEDLINE
[do] DOI:10.1038/srep08034


  6 / 2802 MEDLINE  
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[PMID]:25488911
[Au] Autor:Chang Y; Lan YY; Hsiao JR; Chang NS
[Ad] Endereço:National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan 70456, Taiwan Graduate Institute of Basic Medical Science, Medical College, National Cheng Kung University, Tainan 70101, Taiwan yaochang@nhri.org.tw.
[Ti] Título:Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductase.
[So] Source:Exp Biol Med (Maywood);240(3):329-37, 2015 Mar.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:WW domain-containing oxidoreductase (WWOX) is a well-documented tumor suppressor protein that controls growth, survival, and metastasis of malignant cells. To counteract WWOX's suppressive effects, cancer cells have developed many strategies either to downregulate WWOX expression or to functionally inactivate WWOX. Relatively unknown is, in the context of those cancers associated with certain viruses or bacteria, how the oncogenic pathogens deal with WWOX. Here we review recent studies showing different strategies utilized by three cancer-associated pathogens. Helicobactor pylori reduces WWOX expression through promoter hypermethylation, an epigenetic mechanism also occurring in many other cancer cells. WWOX has a potential to block canonical NF-κB activation and tumorigenesis induced by Tax, an oncoprotein of human T-cell leukemia virus. Tax successfully overcomes the blockage by inhibiting WWOX expression through activation of the non-canonical NF-κB pathway. On the other hand, latent membrane protein 2A of Epstein-Barr virus physically interacts with WWOX and redirects its function to trigger a signaling pathway that upregulates matrix metalloproteinase 9 and cancer cell invasion. These reports may be just "the tip of the iceberg" regarding multiple interactions between WWOX and oncogenic microbes. Further studies in this direction should expand our understanding of infection-driven oncogenesis.
[Mh] Termos MeSH primário: Deltaretrovirus/fisiologia
Helicobacter pylori/fisiologia
Herpesvirus Humano 4/fisiologia
Oxirredutases/fisiologia
Proteínas Supressoras de Tumor/fisiologia
[Mh] Termos MeSH secundário: Carcinogênese
Regulação para Baixo/fisiologia
Seres Humanos
Transdução de Sinais/fisiologia
Oxidorredutase com Domínios WW
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Tumor Suppressor Proteins); EC 1.- (Oxidoreductases); EC 1.1.1.- (WW Domain-Containing Oxidoreductase); EC 1.1.1.- (WWOX protein, human)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141210
[St] Status:MEDLINE
[do] DOI:10.1177/1535370214561957


  7 / 2802 MEDLINE  
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[PMID]:25413015
[Au] Autor:Gallo RC
[Ad] Endereço:Institute of Human Virology, University of Maryland School of Medicine; Global Virus Network, Baltimore, Maryland.
[Ti] Título:A historical personal perspective on human retroviruses and their infection of T cells.
[So] Source:Transfusion;55(1):1-9, 2015 Jan.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por Retroviridae/história
Retroviridae
Linfócitos T/virologia
Virologia/história
[Mh] Termos MeSH secundário: Síndrome de Imunodeficiência Adquirida/história
Animais
Deltaretrovirus/isolamento & purificação
História do Século XX
História do Século XXI
Seres Humanos
Neoplasias/história
Neoplasias/virologia
Retroviridae/classificação
Retroviridae/enzimologia
Retroviridae/isolamento & purificação
Retroviridae/fisiologia
Infecções por Retroviridae/virologia
Linfócitos T/efeitos dos fármacos
[Pt] Tipo de publicação:AUTOBIOGRAPHY; BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Gallo RC
[Em] Mês de entrada:1503
[Cu] Atualização por classe:150113
[Lr] Data última revisão:
150113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141122
[St] Status:MEDLINE
[do] DOI:10.1111/trf.12935


  8 / 2802 MEDLINE  
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[PMID]:25124072
[Au] Autor:Keshvari M; Hajibeigi B; Azarkeivan A; Keyvani H; Behnava B; Saiedi Hosseini SY; Sharafi H; Alavian SM
[Ad] Endereço:Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine; Department of Clinical Hepatology, Middle East Liver Disease (MELD) Center.
[Ti] Título:Seroepidemiology of human T-cell lymphotropic virus among Iranian adult thalassemic patients.
[So] Source:Transfus Med;24(4):227-32, 2014 Aug.
[Is] ISSN:1365-3148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A large number of transfusion-dependent thalassemic patients is at a substantial risk for transfusion-transmitted infections. Human T-cell lymphotropic virus (HTLV) is a blood-borne pathogen and can be transmitted via cellular products. We aimed to evaluate the seroprevalence of HTLV in transfusion-dependent thalassemic patients referred to Tehran Adult Thalassemia Clinic. METHODS: From 2008 to 2010, 257 transfusion-dependent thalassemic patients who referred to Tehran Adult Thalassemia Clinic were enrolled. The seroprevalence of HTLV, hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV were assessed using enzyme-linked immunosorbant assay (ELISA). Also, the samples with positive result for anti-HTLVAb (by ELISA) were reassessed using Western blot for HTLV. RESULTS: Among the 257 transfusion-dependent thalassemic patients who were tested for anti-HTLVAb, 29 (11.3%, 95% CI = 7.8-15.6%) were found to be anti-HTLVAb positive by ELISA and Western blot. No case was detected to be HBsAg positive, whereas 16% had HBV seroconversion criteria, and more than 95% had anti-HBsAb in their sera. Also, 103 (40.1%) patients were HCV seropositive, 13 (5.1%) patients of which were co-infected with HCV/HTLV. Among the HTLV-infected patients, 44.8% were co-infected with HCV, whereas 39.5% of HTLV-seronegative individuals were HCV mono-infected (P > 0.05). CONCLUSION: This study showed that transfusion-dependent thalassemic patients were in higher risk for transmission of different blood-borne pathogens such as HTLV. The screening of HTLV in Iranian blood donors is recommended.
[Mh] Termos MeSH primário: Patógenos Transmitidos pelo Sangue
Infecções por Deltaretrovirus
Deltaretrovirus
Talassemia/epidemiologia
Talassemia/terapia
Reação Transfusional
[Mh] Termos MeSH secundário: Adulto
Infecções por Deltaretrovirus/epidemiologia
Infecções por Deltaretrovirus/transmissão
Feminino
Seres Humanos
Irã (Geográfico)/epidemiologia
Masculino
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1505
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140816
[St] Status:MEDLINE
[do] DOI:10.1111/tme.12133


  9 / 2802 MEDLINE  
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Lampe, Elisabeth
Vicente, Ana Carolina P
PubMed Central Texto completo
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[PMID]:25083768
[Au] Autor:Soares CC; Georg I; Lampe E; Lewis L; Morgado MG; Nicol AF; Pinho AA; Salles RC; Teixeira SL; Vicente AC; Viscidi RP; Gomes SA
[Ad] Endereço:Laboratório de Virologia Molecular, IOC, Fiocruz, Rio de Janeiro, Brasil.
[Ti] Título:HIV-1, HBV, HCV, HTLV, HPV-16/18, and Treponema pallidum infections in a sample of Brazilian men who have sex with men.
[So] Source:PLoS One;9(8):e102676, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Men who have sex with men (MSM) are more vulnerable to blood-borne infections and/or sexually-transmitted infections (STI). This study was conducted to estimate the prevalences of mono and co-infections of HIV-1 and other blood-borne/STIs in a sample of MSM in Campinas, Brazil. METHODS: Responding Driven Sampling (RDS) was used for recruitment of MSM. Serum samples collected from 558 MSM were analyzed for the presence of serological markers for HIV-1, HBV, HCV, HTLV, HPV-16/18, and T. pallidum infections. RESULTS: The highest prevalences of infection in serum samples were found for HPV-16 and 18 (31.9% and 20.3%, respectively). Approximately 8% of the study population showed infection with HIV-1, and within that group, 27.5% had recently become infected with HIV-1. HBV infection and syphilis were detected in 11.4% and 10% of the study population, respectively, and the rates of HTLV and HCV infection were 1.5% and 1%, respectively. With the exception of HTLV, all other studied infections were usually found as co-infections rather then mono-infections. The rates of co-infection for HCV, HPV-18, and HIV-1 were the highest among the studied infections (100%, 83%, and 85%, respectively). Interestingly, HTLV infection was usually found as a mono-infection in the study group, whereas HCV was found only as a co-infection. CONCLUSIONS: The present findings highlight the need to educate the MSM population concerning their risk for STIs infections and methods of prevention. Campaigns to encourage vaccination against HBV and HPV could decrease the rates of these infections in MSM.
[Mh] Termos MeSH primário: Homossexualidade Masculina
Comportamento Sexual
Doenças Sexualmente Transmissíveis/epidemiologia
Sífilis/epidemiologia
Viroses/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Brasil/epidemiologia
Coinfecção
Deltaretrovirus
HIV-1
Hepacivirus
Vírus da Hepatite B
Papillomavirus Humano 16
Papillomavirus Humano 18
Seres Humanos
Masculino
Meia-Idade
Prevalência
Fatores de Risco
Estudos Soroepidemiológicos
Doenças Sexualmente Transmissíveis/microbiologia
Doenças Sexualmente Transmissíveis/virologia
Sífilis/microbiologia
Treponema pallidum
Viroses/virologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1504
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140802
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0102676


  10 / 2802 MEDLINE  
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[PMID]:25037487
[Au] Autor:Mei S; Zhu H
[Ad] Endereço:Bioinformatics Section, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China. meisygle@gmail.com.
[Ti] Título:Computational reconstruction of proteome-wide protein interaction networks between HTLV retroviruses and Homo sapiens.
[So] Source:BMC Bioinformatics;15:245, 2014 Jul 18.
[Is] ISSN:1471-2105
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Human T-cell leukemia viruses (HTLV) tend to induce some fatal human diseases like Adult T-cell Leukemia (ATL) by targeting human T lymphocytes. To indentify the protein-protein interactions (PPI) between HTLV viruses and Homo sapiens is one of the significant approaches to reveal the underlying mechanism of HTLV infection and host defence. At present, as biological experiments are labor-intensive and expensive, the identified part of the HTLV-human PPI networks is rather small. Although recent years have witnessed much progress in computational modeling for reconstructing pathogen-host PPI networks, data scarcity and data unavailability are two major challenges to be effectively addressed. To our knowledge, no computational method for proteome-wide HTLV-human PPI networks reconstruction has been reported. RESULTS: In this work we develop Multi-instance Adaboost method to conduct homolog knowledge transfer for computationally reconstructing proteome-wide HTLV-human PPI networks. In this method, the homolog knowledge in the form of gene ontology (GO) is treated as auxiliary homolog instance to address the problems of data scarcity and data unavailability, while the potential negative knowledge transfer is automatically attenuated by AdaBoost instance reweighting. The cross validation experiments show that the homolog knowledge transfer in the form of independent homolog instances can effectively enrich the feature information and substitute for the missing GO information. Moreover, the independent tests show that the method can validate 70.3% of the recently curated interactions, significantly exceeding the 2.1% recognition rate by the HT-Y2H experiment. We have used the method to reconstruct the proteome-wide HTLV-human PPI networks and further conducted gene ontology based clustering of the predicted networks for further biomedical research. The gene ontology based clustering analysis of the predictions provides much biological insight into the pathogenesis of HTLV retroviruses. CONCLUSIONS: The Multi-instance AdaBoost method can effectively address the problems of data scarcity and data unavailability for the proteome-wide HTLV-human PPI interaction networks reconstruction. The gene ontology based clustering analysis of the predictions reveals some important signaling pathways and biological modules that HTLV retroviruses are likely to target.
[Mh] Termos MeSH primário: Deltaretrovirus/genética
Mapeamento de Interação de Proteínas/métodos
Proteômica/métodos
[Mh] Termos MeSH secundário: Análise por Conglomerados
Ontologia Genética
Interações Hospedeiro-Patógeno
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1410
[Cu] Atualização por classe:150805
[Lr] Data última revisão:
150805
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140720
[St] Status:MEDLINE
[do] DOI:10.1186/1471-2105-15-245



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