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Lemos, Marcílio Figueiredo
Moreira, Regina Celia
Texto completo SciELO Brasil
[PMID]:29236927
[Au] Autor:Caterino-de-Araujo A; Alves FA; Campos KR; Lemos MF; Moreira RC
[Ad] Endereço:Centro de Imunologia, Laboratório de Pesquisa em HTLV, Instituto Adolfo Lutz, Secretaria de Estado da Saúde de São Paulo, São Paulo, SP, Brasil.
[Ti] Título:Making the invisible visible: searching for human T-cell lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) in Brazilian patients with viral hepatitis B and C.
[So] Source:Mem Inst Oswaldo Cruz;113(2):130-134, 2018 Feb.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:With this study, the authors hope to alert clinicians regarding the presence of human T-cell lymphotropic virus type 1 and 2 (HTLV-1/-2) infections in patients with viral hepatitis B and C in Brazil. HTLV-1/-2 were detected in 1.3% of hepatitis B virus (HBV)- and 5.3% of hepatitis C virus (HCV)-infected blood samples sent for laboratory viral load measurements. A partial association of human immunodeficiency virus (HIV)-1 and HTLV-1/-2 infection was detected in patients with HCV (HIV+, 27.3%), whereas this association was almost 100% in HBV-infected patients (HIV+, all except one). The high prevalence of HTLV-1/-2 infection among patients with hepatitis C was of concern, as HTLV-1/-2 could change the natural course of subsequent liver disease. The authors suggest including HTLV-1/-2 serology in the battery of tests used when following patients with viral hepatitis in Brazil, regardless of the HIV status.
[Mh] Termos MeSH primário: Infecções por HTLV-I/diagnóstico
Infecções por HTLV-II/diagnóstico
Hepatite B/complicações
Hepatite C/complicações
[Mh] Termos MeSH secundário: Brasil/epidemiologia
Infecções por HTLV-I/complicações
Infecções por HTLV-I/epidemiologia
Infecções por HTLV-II/complicações
Infecções por HTLV-II/epidemiologia
Hepatite B/epidemiologia
Hepatite C/epidemiologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Vírus 2 Linfotrópico T Humano/isolamento & purificação
Seres Humanos
Notificação Compulsória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


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[PMID]:28193549
[Au] Autor:Rodgers MA; Vallari AS; Harris B; Yamaguchi J; Holzmayer V; Forberg K; Berg MG; Kenmenge J; Ngansop C; Awazi B; Mbanya D; Kaptue L; Brennan C; Cloherty G; Ndembi N
[Ad] Endereço:Abbott Laboratories, Abbott Park, IL, USA. Electronic address: mary.rodgers@abbott.com.
[Ti] Título:Identification of rare HIV-1 Group N, HBV AE, and HTLV-3 strains in rural South Cameroon.
[So] Source:Virology;504:141-151, 2017 Apr.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Surveillance of emerging viral variants is critical to ensuring that blood screening and diagnostic tests detect all infections regardless of strain or geographic location. In this study, we conducted serological and molecular surveillance to monitor the prevalence and diversity of HIV, HBV, and HTLV in South Cameroon. The prevalence of HIV was 8.53%, HBV was 10.45%, and HTLV was 1.04% amongst study participants. Molecular characterization of 555 HIV-1 specimens identified incredible diversity, including 7 subtypes, 12 CRFs, 6 unclassified, 24 Group O and 2 Group N infections. Amongst 401 HBV sequences were found a rare HBV AE recombinant and two emerging sub-genotype A strains. In addition to HTLV-1 and HTLV-2 strains, sequencing confirmed the fifth known HTLV-3 infection to date. Continued HIV/HBV/HTLV surveillance and vigilance for newly emerging strains in South Cameroon will be essential to ensure diagnostic tests and research stay a step ahead of these rapidly evolving viruses.
[Mh] Termos MeSH primário: Infecções por HIV/epidemiologia
HIV-1/classificação
Infecções por HTLV-I/epidemiologia
Vírus da Hepatite B/genética
Hepatite B Crônica/epidemiologia
Vírus 1 Linfotrópico T Humano/genética
Vírus 2 Linfotrópico T Humano/genética
Vírus 3 Linfotrópico T Humano/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anticorpos Antivirais/sangue
Antígenos Virais/sangue
Sequência de Bases
Camarões/epidemiologia
Criança
Pré-Escolar
DNA Viral/genética
Feminino
Genoma Viral/genética
Infecções por HIV/virologia
HIV-1/genética
Infecções por HTLV-I/virologia
Vírus da Hepatite B/classificação
Vírus da Hepatite B/isolamento & purificação
Hepatite B Crônica/virologia
Vírus 1 Linfotrópico T Humano/classificação
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Vírus 2 Linfotrópico T Humano/classificação
Vírus 2 Linfotrópico T Humano/isolamento & purificação
Vírus 3 Linfotrópico T Humano/classificação
Vírus 3 Linfotrópico T Humano/isolamento & purificação
Seres Humanos
Lactente
Masculino
Meia-Idade
Análise de Sequência de DNA
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Antigens, Viral); 0 (DNA, Viral)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE


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[PMID]:26899860
[Au] Autor:Salehi M; Shokouhi Mostafavi SK; Ghasemian A; Gholami M; Kazemi-Vardanjani A; Rahimi MK
[Ad] Endereço:Medical Diagnostic Laboratory of Neyshabour, Center of Medical, Pathological and Genetic Diagnostic Services, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran.
[Ti] Título:Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014.
[So] Source:Iran Biomed J;21(1):57-60, 2017 Jan.
[Is] ISSN:2008-823X
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Retroviruses of human T-lymphotropic viruses (HTLV-1 and HTLV-2) have been demonstrated to be endemic in the north-eastern region of Iran. This study was aimed to determine the HTLV-1 and HTLV-2 prevalence among healthy individuals in Neyshabur City during 2010-2014. METHODS: A total of 8054 blood samples were collected from healthy participants in Neyshabur, North-Eastern Iran. The blood samples were screened for the presence of specific antibodies against HTLV-1 and HTLV-2 by using ELISA according to the manufacturer's instructions. RESULTS: The overall seropositivity rate for HTLV-1 and HTLV-2 was found to be 6.55% (528 out of 8054) among participants. CONCLUSION: Both HTLV-1 and HTLV-2 were demonstrated to be at a high rate in healthy individuals. However, a smaller number of asymptomatic carriers were found in this study, as compared to those identified in previous investigations in the city.
[Mh] Termos MeSH primário: Anticorpos Anti-HTLV-I/sangue
Infecções por HTLV-I/epidemiologia
Anticorpos Anti-HTLV-II/sangue
Infecções por HTLV-II/epidemiologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Vírus 2 Linfotrópico T Humano/isolamento & purificação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Ensaio de Imunoadsorção Enzimática
Feminino
Infecções por HTLV-I/virologia
Infecções por HTLV-II/virologia
Seres Humanos
Lactente
Irã (Geográfico)/epidemiologia
Masculino
Prevalência
Estudos Soroepidemiológicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HTLV-I Antibodies); 0 (HTLV-II Antibodies)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160223
[St] Status:MEDLINE


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[PMID]:28329538
[Au] Autor:Gittler J; Martires K; Terushkin V; Brinster N; Ramsay D
[Ad] Endereço:Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.
[Ti] Título:Primary cutaneous smoldering adult T-cell leukemia/ lymphoma.
[So] Source:Dermatol Online J;22(12), 2016 Dec 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:HTLV-1 is a virus that is endemic in southwesternJapan and the Caribbean and has been implicatedin the development of ATLL. ATLL, which is anuncommon malignant condition of peripheralT-lymphocytes, is characterized by four clinicalsubtypes, which include acute, lymphomatous,chronic, and smoldering types, that are based onLDH levels, calcium levels, and extent of organinvolvement. We present a 52-year- old woman withpruritic patches with scale on the buttocks and withtender, hyperpigmented macules and papules oftwo-years duration. Histopathologic examinationwas suggestive of mycosis fungoides, laboratoryresults showed HTLV-I and II, and the patient wasdiagnosed with primary cutaneous ATLL. We reviewthe literature on HTLV-1 and ATLL and specifically theprognosis of cutaneous ATLL. The literature suggeststhat a diagnosis of ATLL should be considered amongpatients of Caribbean origin or other endemicareas with skin lesions that suggest a cutaneousT-cell lymphoma, with clinicopathologic features ofmycosis fungoides. Differentiation between ATLLand cutaneous T-cell lymphoma is imperative as theyhave different prognoses and treatment approaches.
[Mh] Termos MeSH primário: Anemia Refratária com Excesso de Blastos/diagnóstico
Leucemia-Linfoma de Células T do Adulto/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Anemia Refratária com Excesso de Blastos/patologia
Anemia Refratária com Excesso de Blastos/virologia
Western Blotting
Ensaio de Imunoadsorção Enzimática
Feminino
Anticorpos Anti-HTLV-I/imunologia
Anticorpos Anti-HTLV-II/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Vírus 2 Linfotrópico T Humano/imunologia
Seres Humanos
Leucemia-Linfoma de Células T do Adulto/patologia
Leucemia-Linfoma de Células T do Adulto/virologia
Meia-Idade
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (HTLV-I Antibodies); 0 (HTLV-II Antibodies)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:27980301
[Au] Autor:Kawano R; Niino D; Ohshima K
[Ad] Endereço:Second Department of Pathology, Kurume University School of Medicine.
[Ti] Título:Six Cases of CD20-Positive Adult T-Cell Leukemia.
[So] Source:J Clin Exp Hematop;56(2):119-125, 2016.
[Is] ISSN:1880-9952
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Adult T-cell leukaemia/lymphoma (ATLL) is a neoplasm originating in mature CD4 peripheral T cells. However, rare cases of CD20 ATLL have been reported. Here, we describe six cases of CD20 ATLL diagnosed in our department. The median age was 79 years (range, 54-90 years); two patients were men, and four were women. Elevated lactate dehydrogenase was observed in four cases. All cases were lymphoma type and positive for human T-lymphotropic virus-1 (HTLV-1). HTLV-1 proviral DNA was detected in four cases. The Ann Arbor stage was I, II, or IV in one patient each and III in three patients. The clinical course was poor in almost all cases. Tumour cells were large in all cases, and flow cytometry revealed CD20 lymphoma cells in five of six cases. Immunohistochemistry revealed lymphoma cells positive for CD20, CD3, CD4, and CCR4 and negative for CD8, CD79a, and PAX5 in all cases. CD20 expression was lower than that in normal B cells. One case was initially misdiagnosed as diffuse large B-cell lymphoma. Thus, combined use of an antibody panel and molecular genetic studies is important to avoid misdiagnosing ATLL as B-cell lymphoma.
[Mh] Termos MeSH primário: Antígenos CD28/biossíntese
Regulação Leucêmica da Expressão Gênica
Infecções por HTLV-I
Infecções por HTLV-II
Vírus 1 Linfotrópico T Humano
Vírus 2 Linfotrópico T Humano
Leucemia-Linfoma de Células T do Adulto
Proteínas de Neoplasias/biossíntese
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Infecções por HTLV-I/diagnóstico
Infecções por HTLV-I/metabolismo
Infecções por HTLV-II/diagnóstico
Infecções por HTLV-II/metabolismo
Seres Humanos
Leucemia-Linfoma de Células T do Adulto/diagnóstico
Leucemia-Linfoma de Células T do Adulto/metabolismo
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD28 Antigens); 0 (Neoplasm Proteins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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Lopes, Carmen Luci Rodrigues
Martins, Regina Maria Bringel
Texto completo SciELO Brasil
[PMID]:27828621
[Au] Autor:Kozlowski AG; Matos MA; Carneiro MA; Lopes CL; Teles SA; Vicente CP; Martins RM
[Ad] Endereço:Universidade Federal de Goiás (UFG), Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
[Ti] Título:SEROPREVALENCE OF HTLV IN A POPULATION OF HIV1-INFECTED PATIENTS IN MIDWESTERN BRAZIL.
[So] Source:Rev Inst Med Trop Sao Paulo;58:80, 2016 Nov 03.
[Is] ISSN:1678-9946
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Human T-cell lymphotropic virus (HTLV) may affect the clinical course of human immunodeficiency virus 1 (HIV1). Both infections are common in endemic areas because these viruses share similar routes of transmission. The aim of this study was to estimate the seroprevalence of HTLV1/2 in a population of HIV1-infected patients in the state of Goiás, Midwestern Brazil. Of the 505 studied patients, four (0.79%) were positive for anti-HTLV1/2 by enzyme-linked immunosorbent assay (ELISA), with HTLV1 infection confirmed by line immunoassay (LIA) and polymerase chain reaction (PCR) in all of the ELISA-positive samples. No cases of HTLV2 infection were observed. The prevalence of HTLV1/HIV1 coinfection was 0.79% (4/505; 95% CI: 0.25-2.16). All the coinfected patients reported sexual risk behaviors and only one reported intravenous drug use. Sequencing of the viral long terminal repeat (LTR) region and phylogenetic analysis revealed that the four HTLV1 isolates belonged to the Transcontinental a subgroup of the Cosmopolitan (1a) subtype, the most frequent subgroup detected in Brazil. This study shows a low prevalence of HTLV1/2 in HIV1-infected patients in Midwestern Brazil.
[Mh] Termos MeSH primário: Coinfecção/epidemiologia
Infecções por HIV/epidemiologia
Infecções por HTLV-I/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Brasil/epidemiologia
Ensaio de Imunoadsorção Enzimática
Feminino
Vírus 1 Linfotrópico T Humano/genética
Vírus 1 Linfotrópico T Humano/imunologia
Vírus 2 Linfotrópico T Humano/genética
Vírus 2 Linfotrópico T Humano/imunologia
Seres Humanos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase
Prevalência
Estudos Soroepidemiológicos
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


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[PMID]:27650229
[Au] Autor:Rossheim AE; Cunningham TD; Troy SB
[Ad] Endereço:Center for Health Analytics and Discovery, Eastern Virginia Medical School, Norfolk, VA.
[Ti] Título:Human T-lymphotropic Virus Co-infections in Adults Infected With Human Immunodeficiency Virus.
[So] Source:Am J Med Sci;352(3):258-60, 2016 Sep.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Human T-lymphotropic virus type 1 or 2 (HTLV-1/2) co-infection in patients infected with the human immunodeficiency virus (HIV) can lead to increased morbidity. Because HTLV-1/2 shares a similar transmission route with HIV, HTLV-1/2 infection may be more prevalent in HIV-infected individuals. However, rates of HTLV-1/2 co-infection among HIV-infected individuals have not been studied recently in the United States. MATERIALS AND METHODS: We conducted a cross-sectional study using serum from 292 HIV-infected subjects from one clinic in Virginia. Serum samples were tested for co-infection with HTLV-1/2 by commercial ELISA; positive results were then confirmed via western blot, which also differentiated between HTLV-1 and -2. RESULTS: Seven (2.4%) of the subjects were co-infected with HTLV-2. One subject (among the seven co-infected with HTLV-2) was co-infected with HTLV-1 (0.3%). The only demographic factor significantly associated with HTLV-2 infection was history of intravenous drug abuse (p=0.002). CONCLUSIONS: While our results are limited to a single city, our low rates of co-infection do not support routine screening for HTLV-1/2 co-infection among HIV-infected individuals in the United States.
[Mh] Termos MeSH primário: Coinfecção/sangue
Infecções por HIV/virologia
Infecções por HTLV-I/virologia
Infecções por HTLV-II/virologia
[Mh] Termos MeSH secundário: Coinfecção/epidemiologia
Estudos Transversais
Ensaio de Imunoadsorção Enzimática
Feminino
Infecções por HIV/complicações
Infecções por HIV/epidemiologia
Infecções por HTLV-I/complicações
Infecções por HTLV-I/epidemiologia
Infecções por HTLV-II/complicações
Infecções por HTLV-II/epidemiologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Vírus 2 Linfotrópico T Humano/isolamento & purificação
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160922
[St] Status:MEDLINE


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[PMID]:27529270
[Au] Autor:Usadi B; Bruhn R; Lin J; Lee TH; Blackburn E; Murphy EL
[Ad] Endereço:School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA. benusadi@gmail.com.
[Ti] Título:Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects.
[So] Source:Viruses;8(8), 2016 Aug 11.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-cell lymphotropic virus type 1 (HTLV-1), 45 human T-cell lymphotropic virus type 2 (HTLV-2), and 45 seronegative subjects was selected from the larger HTLV Outcomes Study (HOST) cohort, matched on age, sex and race/ethnicity. Telomere-to-single-copy gene (T/S) ratio (a measure of TL) and HTLV-1 and HTLV-2 proviral loads were measured in peripheral blood mononuclear cells (PBMCs) using quantitative PCR (qPCR). Vibration sensation measured by tuning fork during neurologic examinations performed as part of the HOST study allowed for an assessment of peripheral neuropathy. TL was compared between groups using t-tests, linear and logistic regression. Mean T/S ratio was 1.02 ± 0.16 in HTLV-1, 1.03 ± 0.17 in HTLV-2 and 0.99 ± 0.18 in HTLV seronegative subjects (p = 0.322). TL was not associated with HTLV-1 or -2 proviral load. Shorter TL was significantly associated with impaired vibration sense in the HTLV-2 positive group only. Overall, we found no evidence that telomere length was affected by chronic HTLV-1 and HTLV-2 infection. That TL was only associated with peripheral neuropathy in the HTLV-2-positive group is intriguing, but should be interpreted cautiously. Studies with larger sample size and telomere length measurement in lymphocyte subsets may clarify the relationship between TL and HTLV-infection.
[Mh] Termos MeSH primário: Infecções por HTLV-I/patologia
Infecções por HTLV-II/patologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Vírus 2 Linfotrópico T Humano/isolamento & purificação
Provírus/isolamento & purificação
Telômero
Carga Viral
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Infecções por HTLV-I/virologia
Infecções por HTLV-II/virologia
Vírus 1 Linfotrópico T Humano/genética
Vírus 2 Linfotrópico T Humano/genética
Seres Humanos
Masculino
Meia-Idade
Provírus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160817
[St] Status:MEDLINE


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[PMID]:27310836
[Au] Autor:Switzer WM; Tang S; Zheng H; Shankar A; Sprinkle PS; Sullivan V; Granade TC; Heneine W
[Ad] Endereço:Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30329, United States of America.
[Ti] Título:Dual Simian Foamy Virus/Human Immunodeficiency Virus Type 1 Infections in Persons from Côte d'Ivoire.
[So] Source:PLoS One;11(6):e0157709, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Zoonotic transmission of simian retroviruses in West-Central Africa occurring in primate hunters has resulted in pandemic spread of human immunodeficiency viruses (HIVs) and human T-lymphotropic viruses (HTLVs). While simian foamy virus (SFV) and simian T- lymphotropic virus (STLV)-like infection were reported in healthy persons exposed to nonhuman primates (NHPs) in West-Central Africa, less is known about the distribution of these viruses in Western Africa and in hospitalized populations. We serologically screened for SFV and STLV infection using 1,529 specimens collected between 1985 and 1997 from Côte d'Ivoire patients with high HIV prevalence. PCR amplification and analysis of SFV, STLV, and HIV/SIV sequences from PBMCs was used to investigate possible simian origin of infection. We confirmed SFV antibodies in three persons (0.2%), two of whom were HIV-1-infected. SFV polymerase (pol) and LTR sequences were detected in PBMC DNA available for one HIV-infected person. Phylogenetic comparisons with new SFV sequences from African guenons showed infection likely originated from a Chlorocebus sabaeus monkey endemic to Côte d'Ivoire. 4.6% of persons were HTLV seropositive and PCR testing of PBMCs from 15 HTLV seroreactive persons identified nine with HTLV-1 and one with HTLV-2 LTR sequences. Phylogenetic analysis showed that two persons had STLV-1-like infections, seven were HTLV-1, and one was an HTLV-2 infection. 310/858 (53%), 8/858 (0.93%), and 18/858 (2.1%) were HIV-1, HIV-2, and HIV-positive but undifferentiated by serology, respectively. No SIV sequences were found in persons with HIV-2 antibodies (n = 1) or with undifferentiated HIV results (n = 7). We document SFV, STLV-1-like, and dual SFV/HIV infection in Côte d'Ivoire expanding the geographic range for zoonotic simian retrovirus transmission to West Africa. These findings highlight the need to define the public health consequences of these infections. Studying dual HIV-1/SFV infections in immunocompromised populations may provide a new opportunity to better understand SFV pathogenicity and transmissibility in humans.
[Mh] Termos MeSH primário: Infecções por Deltaretrovirus/diagnóstico
Infecções por HIV/diagnóstico
HIV-1/isolamento & purificação
Infecções por Retroviridae/diagnóstico
Vírus Espumoso dos Símios/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/sangue
Cercopithecus aethiops
Coinfecção
Costa do Marfim/epidemiologia
DNA Viral/genética
Infecções por Deltaretrovirus/epidemiologia
Infecções por Deltaretrovirus/virologia
Infecções por HIV/epidemiologia
Infecções por HIV/virologia
HIV-1/classificação
HIV-1/genética
HIV-2/classificação
HIV-2/genética
HIV-2/isolamento & purificação
Vírus 1 Linfotrópico T Humano/classificação
Vírus 1 Linfotrópico T Humano/genética
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Vírus 2 Linfotrópico T Humano/classificação
Vírus 2 Linfotrópico T Humano/genética
Vírus 2 Linfotrópico T Humano/isolamento & purificação
Seres Humanos
Leucócitos Mononucleares/virologia
Doenças dos Macacos/diagnóstico
Doenças dos Macacos/epidemiologia
Doenças dos Macacos/virologia
Filogenia
Infecções por Retroviridae/epidemiologia
Infecções por Retroviridae/virologia
Vírus Espumoso dos Símios/classificação
Vírus Espumoso dos Símios/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (DNA, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0157709


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[PMID]:27223634
[Au] Autor:Jõgeda EL; Avi R; Pauskar M; Kallas E; Karki T; Des Jarlais D; Uusküla A; Lutsar I; Huik K
[Ad] Endereço:Department of Microbiology, Faculty of Medicine, University of Tartu, Tartu, Estonia(1). Electronic address: ene-ly.jogeda@ut.ee.
[Ti] Título:Human T-lymphotropic virus types 1 and 2 are rare among intravenous drug users in Eastern Europe.
[So] Source:Infect Genet Evol;43:83-5, 2016 09.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In Europe, human T-lymphotropic virus (HTLV) type 2 mainly occurs among intravenous drug users (IDUs) with prevalence up to 15% and HTLV-1 among general population with prevalence <1%. However, there is no data regarding the prevalence of HTLV-1 or HTLV-2 in Eastern European IDUs population where HIV prevalence is relatively high. We aimed to determine the prevalence and genotypes of HTLV-1/HTLV-2 among IDUs and healthy volunteers in Estonia. METHODS: The study included 345 IDUs and 138 healthy volunteers. The presence of HTLV-1/HTLV-2 was determined by nested PCR; positive and negative controls were used in every PCR run. RESULTS: The analysed IDUs resembled the IDUs of HIV epidemic in Estonia: mainly male (79%) with median age of 30years (interquartile range [IQR] 25-34), and prolonged duration of intravenous drug usage (11years; IQR 7-14). The prevalence exposure to blood-borne viral infections was high - 50% were HIV positive, 88% hepatitis C positive, 67% hepatitis B positive. Of IDUs, 64% reported receptive needle sharing in the past and 18% at least once a month during last six months. None of the IDUs carried HTLV-1 but there was a case of HTLV-2 (prevalence 0.3%; 95% CI 0.1-1.6). All healthy volunteers were HTLV-1 and HTLV-2 PCR negative. CONCLUSION: This is the first study investigating the prevalence of HTLV-1/HTLV-2 among high risk population and healthy volunteers in Eastern European region. Our results suggest that despite other widely spread blood-borne infections (e.g. HIV, HBV, HCV) HTLV-1 and HTLV-2 are rare among IDUs in Estonia.
[Mh] Termos MeSH primário: Coinfecção/epidemiologia
Infecções por HTLV-I/epidemiologia
Infecções por HTLV-II/epidemiologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Vírus 2 Linfotrópico T Humano/isolamento & purificação
Abuso de Substâncias por Via Intravenosa/virologia
[Mh] Termos MeSH secundário: Adulto
Estônia
Europa Oriental
Feminino
Infecções por HIV/epidemiologia
Infecções por HTLV-I/virologia
Infecções por HTLV-II/virologia
Hepatite B/epidemiologia
Hepatite C/epidemiologia
Vírus 1 Linfotrópico T Humano/genética
Vírus 2 Linfotrópico T Humano/genética
Seres Humanos
Masculino
Meia-Idade
Uso Comum de Agulhas e Seringas/estatística & dados numéricos
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160526
[St] Status:MEDLINE



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