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[PMID]:28918382
[Au] Autor:Stavisky J; Dean RS; Molloy MH
[Ad] Endereço:Centre for Evidence-based Veterinary Medicine, School of Veterinary Medicine and Science, The University of Nottingham, Loughborough, UK.
[Ti] Título:Prevalence of and risk factors for FIV and FeLV infection in two shelters in the United Kingdom (2011-2012).
[So] Source:Vet Rec;181(17):451, 2017 Oct 28.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aims of this study were to determine the prevalence of feline leukaemia virus (FeLV) and feline immunodeficiency virus (FIV) infections in cats presented to two RSPCA (Royal Society for the Prevention of Cruelty to Animals) animal rehoming centres and to identify risk factors for infection. All cats presented at each centre between August 2011 and August 2012 were subjected to a patient-side test for FeLV/FIV on entry. Kittens under three months and cats euthanased within a short time of presentation were excluded from the study. Univariable and multivariable logistic regression were used to separately determine risk factors for FeLV and FIV infections. At shelter A, the prevalence of FIV infection was 11.4 per cent (54/474) and FeLV infection was 3 per cent (14/473), with two FIV/FeLV coinfections identified. At shelter B, the prevalence of FIV infection was 3 per cent (4/135) and FeLV infection was 0 per cent (0/135). Cats at shelter A were significantly more likely than those at shelter B to test positive for FIV (p=0.0024) and FeLV (p=0.048). Male cats were more likely to be infected with FIV (odds ratio 27.1, p=0.001), and thin body condition and musculoskeletal disease were associated with risk of FeLV. Overall, FIV-positive and FeLV-positive cats were significantly older (median ages 5.1 and 4.75 years, respectively) than the uninfected populations (median ages 3.4 and 3.5 years, respectively). This study shows that the prevalence of these diseases varies between shelter populations. Local knowledge combined with the risk factors identified may be useful in focusing resources for population testing strategies.
[Mh] Termos MeSH primário: Síndrome de Imunodeficiência Adquirida Felina/epidemiologia
Abrigo para Animais/estatística & dados numéricos
Vírus da Imunodeficiência Felina/isolamento & purificação
Vírus da Leucemia Felina/isolamento & purificação
Leucemia Felina/epidemiologia
[Mh] Termos MeSH secundário: Animais
Gatos
Instituições de Caridade
Feminino
Masculino
Prevalência
Fatores de Risco
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170918
[St] Status:MEDLINE
[do] DOI:10.1136/vr.103857


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[PMID]:28780918
[Au] Autor:Sato S; Kabeya H; Negishi A; Tsujimoto H; Nishigaki K; Endo Y; Maruyama S
[Ad] Endereço:Laboratory of Veterinary Public Health, Department of Veterinary Medicine,College of Bioresource Sciences, Nihon University,1866 Kameino, Fujisawa, Kanagawa Prefecture, 252-0880,Japan.
[Ti] Título:Molecular survey of Bartonella henselae and Bartonella clarridgeiae in pet cats across Japan by species-specific nested-PCR.
[So] Source:Epidemiol Infect;145(13):2694-2700, 2017 10.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cats are known to be the main reservoir for Bartonella henselae and Bartonella clarridgeiae, which are the agents of 'cat-scratch disease' in humans. In the present study, we investigated the prevalence of the two Bartonella species on 1754 cat bloods collected from all prefectures in Japan during 2007-2008 by a nested-polymerase chain reaction (PCR) targeting the 16S-23S rRNA internal transcribed spacer region. Overall, Bartonella DNA was detected in 4·6% (80/1754) of the cats examined. The nested-PCR showed that 48·8% (39/80) of the positive cats were infected with B. henselae mono-infection, 33·8% (27/80) with B. clarridgeiae mono-infection and 17·5% (14/80) were infected with both species. The prevalence (5·9%; 65/1103) of Bartonella infection in the western part of Japan was significantly higher than that (2·3%; 15/651) of eastern Japan (P < 0·001). Statistical analysis of the cats examined suggested a significant association between Bartonella infection and FeLV infection (OR = 1·9; 95% CI = 1·1-3·4), but not with FIV infection (OR = 1·6; 95% CI = 1·0-2·6).
[Mh] Termos MeSH primário: Bartonella/isolamento & purificação
Doença da Arranhadura de Gato/veterinária
Síndrome de Imunodeficiência Adquirida Felina/epidemiologia
Leucemia Felina/epidemiologia
[Mh] Termos MeSH secundário: Animais
Bartonella/classificação
Bartonella/genética
Bartonella henselae/classificação
Bartonella henselae/genética
Bartonella henselae/isolamento & purificação
Doença da Arranhadura de Gato/epidemiologia
Doença da Arranhadura de Gato/microbiologia
Gatos
Síndrome de Imunodeficiência Adquirida Felina/virologia
Feminino
Vírus da Imunodeficiência Felina/isolamento & purificação
Japão/epidemiologia
Vírus da Leucemia Felina/isolamento & purificação
Leucemia Felina/virologia
Masculino
Reação em Cadeia da Polimerase/veterinária
Prevalência
RNA Ribossômico/análise
RNA Viral/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Ribosomal); 0 (RNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817001601


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[PMID]:28768854
[Au] Autor:Kawasaki J; Kawamura M; Ohsato Y; Ito J; Nishigaki K
[Ad] Endereço:Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
[Ti] Título:Presence of a Shared 5'-Leader Sequence in Ancestral Human and Mammalian Retroviruses and Its Transduction into Feline Leukemia Virus.
[So] Source:J Virol;91(20), 2017 Oct 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recombination events induce significant genetic changes, and this process can result in virus genetic diversity or in the generation of novel pathogenicity. We discovered a new recombinant feline leukemia virus (FeLV) gene harboring an unrelated insertion, termed the X region, which was derived from endogenous gammaretrovirus 4 (FcERV-gamma4). The identified FcERV-gamma4 proviruses have lost their coding capabilities, but some can express their viral RNA in feline tissues. Although the X-region-carrying recombinant FeLVs appeared to be replication-defective viruses, they were detected in 6.4% of tested FeLV-infected cats. All isolated recombinant FeLV clones commonly incorporated a middle part of the FcERV-gamma4 5'-leader region as an X region. Surprisingly, a sequence corresponding to the portion contained in all X regions is also present in at least 13 endogenous retroviruses (ERVs) observed in the cat, human, primate, and pig genomes. We termed this shared genetic feature the commonly shared (CS) sequence. Despite our phylogenetic analysis indicating that all CS-sequence-carrying ERVs are classified as gammaretroviruses, no obvious closeness was revealed among these ERVs. However, the Shannon entropy in the CS sequence was lower than that in other parts of the provirus genome. Notably, the CS sequence of human endogenous retrovirus T had 73.8% similarity with that of FcERV-gamma4, and specific signals were detected in the human genome by Southern blot analysis using a probe for the FcERV-gamma4 CS sequence. Our results provide an interesting evolutionary history for CS-sequence circulation among several distinct ancestral viruses and a novel recombined virus over a prolonged period. Recombination among ERVs or modern viral genomes causes a rapid evolution of retroviruses, and this phenomenon can result in the serious situation of viral disease reemergence. We identified a novel recombinant FeLV gene that contains an unrelated sequence, termed the X region. This region originated from the 5' leader of FcERV-gamma4, a replication-incompetent feline ERV. Surprisingly, a sequence corresponding to the X region is also present in the 5' portion of other ERVs, including human endogenous retroviruses. Scattered copies of the ERVs carrying the unique genetic feature, here named the commonly shared (CS) sequence, were found in each host genome, suggesting that ancestral viruses may have captured and maintained the CS sequence. More recently, a novel recombinant FeLV hijacked the CS sequence from inactivated FcERV-gamma4 as the X region. Therefore, tracing the CS sequences can provide unique models for not only the modern reservoir of new recombinant viruses but also the genetic features shared among ancient retroviruses.
[Mh] Termos MeSH primário: Regiões 5´ não Traduzidas/genética
Retrovirus Endógenos/genética
Genes gag
Genoma Viral
Vírus da Leucemia Felina/genética
Recombinação Genética
[Mh] Termos MeSH secundário: Animais
Gatos/virologia
Evolução Molecular
Gammaretrovirus/genética
Seres Humanos/virologia
Leucemia Felina/virologia
Mamíferos/genética
Mamíferos/virologia
Filogenia
Provírus/genética
Provírus/fisiologia
RNA Viral/genética
Suínos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5' Untranslated Regions); 0 (RNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE


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[PMID]:28510253
[Au] Autor:Lacerda LC; Silva AN; Freitas JS; Cruz RDS; Said RA; Munhoz AD
[Ad] Endereço:Departamento de Ciências Agrárias e Ambientais, Universidade Estadual de Santa Cruz, Ilhéus, BA, Brasil.
[Ti] Título:Feline immunodeficiency virus and feline leukemia virus: frequency and associated factors in cats in northeastern Brazil.
[So] Source:Genet Mol Res;16(2), 2017 May 10.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Our aims were to determine the frequencies of feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) in owned and stray cats in the northeastern region of Brazil, ascertain the status of FeLV infection, and investigate potential associated factors among the owned cats. Blood samples from 200 asymptomatic owned cats and 30 stray cats were processed using nested PCR and commercial immunochromatographic tests to diagnose infections. To evaluate the factors associated with FIV and/or FeLV in owned cats, a semi-structured interview was conducted with each owner about the animal's environment, and these data were subjected to unconditional logistic regression. The frequencies for owned cats were 6% (12/200) and 3% (6/200) for FIV and FeLV, respectively. No owned cat was positive for both viruses. Stray cats showed frequencies of 6.66% (2/30) and 0% (0/30) for FIV and FeLV, respectively. Contact with other cats and living in peri-urban areas were considered to be risk factors (P < 0.05) for FIV. We did not identify any factors associated with infections with FeLV. Our results confirm the presence of these two retroviruses in the region under study. Our use of different diagnostic techniques allowed us to determine the frequency of retroviruses in the feline population more accurately, particularly with regard to infections by FeLV, which have complex pathogenesis.
[Mh] Termos MeSH primário: Gatos/virologia
Síndrome de Imunodeficiência Adquirida Felina/epidemiologia
Vírus da Imunodeficiência Felina/genética
Vírus da Leucemia Felina/genética
Leucemia Felina/epidemiologia
[Mh] Termos MeSH secundário: Animais
Brasil
Síndrome de Imunodeficiência Adquirida Felina/virologia
Feminino
Leucemia Felina/virologia
Masculino
Animais de Estimação/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16029633


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[PMID]:28285597
[Au] Autor:Attipa C; Papasouliotis K; Solano-Gallego L; Baneth G; Nachum-Biala Y; Sarvani E; Knowles TG; Mengi S; Morris D; Helps C; Tasker S
[Ad] Endereço:Molecular Diagnostic Unit, Diagnostic Laboratories, Langford Vets and School of Veterinary Sciences, University of Bristol, Langford, UK. attipacy@gmail.com.
[Ti] Título:Prevalence study and risk factor analysis of selected bacterial, protozoal and viral, including vector-borne, pathogens in cats from Cyprus.
[So] Source:Parasit Vectors;10(1):130, 2017 Mar 13.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Feline infectious agent studies are lacking in Cyprus. The aims of this study were to determine the prevalence and risk factors for various feline infectious agents, including feline vector-borne pathogens (FVBP), in cats from Cyprus. METHODS: A cross-sectional, descriptive, multicentre study was performed on 174 feline samples [138 owned and 36 shelter-feral, including both healthy (43) and non-healthy (131), cats] from private veterinary clinics from all six districts of Cyprus. Real-time quantitative polymerase chain reaction (qPCR) assays were used to detect Mycoplasma haemofelis (Mhf), "Candidatus Mycoplasma haemominutum" (CMhm) and "Candidatus Mycoplasma turicensis" (CMt). The population was tested for four FVBP including Bartonella henselae and Leishmania spp. using qPCR, while conventional PCR assays were used to detect Ehrlichia/Anaplasma spp. and Hepatozoon spp. Serological assays were performed to detect Leishmania infantum antibodies, feline leukaemia virus (FeLV) antigen and feline immunodeficiency virus (FIV) antibodies. Statistical analysis was performed to test associations and possible risk factors between variables and infectious agents. RESULTS: Ninety-six (55.2%) of the 174 cats were PCR-positive for at least one infectious agent. Forty-six cats (26.4%) were haemoplasma positive, including 13 (7.5%) for Mhf, 36 (20.7%) for CMhm and 12 (6.9%) for CMt. Sixty-six cats (37.9%) were positive for Hepatozoon spp., while 19 (10.9%) were positive for B. henselae, four (2.3%) for Leishmania spp. and one (0.6%) for Ehrlichia/Anaplasma spp. Sequencing revealed the presence of Hepatozoon felis, L. infantum and Anaplasma platys. Of the 164 cats that underwent retroviral serology, 10 (6.1%) were FeLV-positive and 31 (18.9%) were FIV-positive, while L. infantum serology was positive in 7 (4.4%) of the 160 cats tested. Multivariable logistic regression revealed significant associations for various infectious agents including L. infantum with each of Hepatozoon spp. and CMt infection. CONCLUSIONS: A high prevalence of infectious agents was found in cats from Cyprus with Mhf, CMhm, CMt, L. infantum, B. henselae, H. felis, A. platys, FeLV and FIV infections reported for the first time. The significant associations between different pathogens provide a better understanding of similarities in the epidemiology of these pathogens and interactions between them.
[Mh] Termos MeSH primário: Infecções Bacterianas/veterinária
Doenças do Gato/epidemiologia
Infecções por Mycoplasma/veterinária
Infecções Protozoárias em Animais/epidemiologia
Infecções por Retroviridae/veterinária
Doenças Transmitidas por Carrapatos/veterinária
[Mh] Termos MeSH secundário: Anaplasma/genética
Anaplasma/isolamento & purificação
Anaplasmose/epidemiologia
Anaplasmose/microbiologia
Animais
Infecções Bacterianas/epidemiologia
Infecções Bacterianas/microbiologia
Doenças do Gato/microbiologia
Doenças do Gato/parasitologia
Doenças do Gato/virologia
Gatos
Coccidiose/epidemiologia
Coccidiose/veterinária
Estudos Transversais
Chipre/epidemiologia
Ehrlichia/genética
Ehrlichia/isolamento & purificação
Ehrlichiose/epidemiologia
Ehrlichiose/microbiologia
Ehrlichiose/veterinária
Análise Fatorial
Feminino
Leishmania infantum/genética
Leishmania infantum/isolamento & purificação
Leishmaniose Visceral/epidemiologia
Leishmaniose Visceral/parasitologia
Leishmaniose Visceral/veterinária
Vírus da Leucemia Felina/genética
Vírus da Leucemia Felina/isolamento & purificação
Masculino
Mycoplasma/genética
Mycoplasma/isolamento & purificação
Infecções por Mycoplasma/epidemiologia
Infecções por Mycoplasma/microbiologia
Prevalência
Reação em Cadeia da Polimerase em Tempo Real/veterinária
Análise de Regressão
Infecções por Retroviridae/epidemiologia
Infecções por Retroviridae/virologia
Medição de Risco
Fatores de Risco
Doenças Transmitidas por Carrapatos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2063-2


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[PMID]:28131385
[Au] Autor:Westman ME; Malik R; Hall E; Sheehy PA; Norris JM
[Ad] Endereço:Sydney School of Veterinary Science, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: mark.westman@sydney.edu.au.
[Ti] Título:Comparison of three feline leukaemia virus (FeLV) point-of-care antigen test kits using blood and saliva.
[So] Source:Comp Immunol Microbiol Infect Dis;50:88-96, 2017 Feb.
[Is] ISSN:1878-1667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Feline leukaemia virus (FeLV) can be a challenging infection to diagnose due to a complex feline host-pathogen relationship and occasionally unreliable test results. This study compared the accuracy of three point-of-care (PoC) FeLV p27 antigen test kits commonly used in Australia and available commercially worldwide (SNAP FIV/FeLV Combo, Witness FeLV/FIV and Anigen Rapid FIV/FeLV), using detection of FeLV provirus by an in-house real-time polymerase chain reaction (qPCR) assay as the diagnostic gold standard. Blood (n=563) and saliva (n=419) specimens were collected from a population of cats determined to include 491 FeLV-uninfected and 72 FeLV-infected individuals (45 progressive infections [p27 and qPCR positive], 27 regressive infections [p27 negative, qPCR positive]). Sensitivity and specificity using whole blood was 63% and 94% for SNAP Combo, 57% and 98% for Witness, and 57% and 98% for Anigen Rapid, respectively. SNAP Combo had a significantly lower specificity using blood compared to the other two kits (P=0.004 compared to Witness, P=0.007 compared to Anigen Rapid). False-positive test results occurred with all three kits using blood, and although using any two kits in parallel increased specificity, no combination of kits completely eliminated the occurrence of false-positive results. We therefore recommend FeLV proviral PCR testing for any cat that tests positive with a PoC FeLV antigen kit, as well as for any cat that has been potentially exposed to FeLV but tests negative with a FeLV antigen kit, before final assignment of FeLV status can be made with confidence. For saliva testing, sensitivity and specificity was 54% and 100%, respectively, for all three test kits. The reduced sensitivity of saliva testing compared to blood testing, although not statistically significant, suggests saliva testing with the current generation of PoC FeLV antigen kits is unsuitable for screening large populations of cats, such as in shelters.
[Mh] Termos MeSH primário: Antígenos Virais/análise
Doenças do Gato/diagnóstico
Ensaio de Imunoadsorção Enzimática/veterinária
Vírus da Leucemia Felina/isolamento & purificação
Infecções por Retroviridae/veterinária
Saliva/virologia
Infecções Tumorais por Vírus/veterinária
[Mh] Termos MeSH secundário: Animais
Austrália
Doenças do Gato/virologia
Gatos/virologia
Vírus da Imunodeficiência Felina/imunologia
Vírus da Leucemia Felina/imunologia
Testes Imediatos
Kit de Reagentes para Diagnóstico/veterinária
Reação em Cadeia da Polimerase em Tempo Real
Infecções por Retroviridae/diagnóstico
Infecções por Retroviridae/virologia
Sensibilidade e Especificidade
Organismos Livres de Patógenos Específicos
Infecções Tumorais por Vírus/diagnóstico
Infecções Tumorais por Vírus/virologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Viral); 0 (Reagent Kits, Diagnostic)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


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[PMID]:28031367
[Au] Autor:Terry A; Kilbey A; Naseer A; Levy LS; Ahmad S; Watts C; Mackay N; Cameron E; Wilson S; Neil JC
[Ad] Endereço:MRC University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom.
[Ti] Título:Barriers to Infection of Human Cells by Feline Leukemia Virus: Insights into Resistance to Zoonosis.
[So] Source:J Virol;91(5), 2017 Mar 01.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The human genome displays a rich fossil record of past gammaretrovirus infections, yet no current epidemic is evident, despite environmental exposure to viruses that infect human cells Feline leukemia viruses (FeLVs) rank high on this list, but neither domestic nor workplace exposure has been associated with detectable serological responses. Nonspecific inactivation of gammaretroviruses by serum factors appears insufficient to explain these observations. To investigate further, we explored the susceptibilities of primary and established human cell lines to FeLV-B, the most likely zoonotic variant. Fully permissive infection was common in cancer-derived cell lines but was also a feature of nontransformed keratinocytes and lung fibroblasts. Cells of hematopoietic origin were generally less permissive and formed discrete groups on the basis of high or low intracellular protein expression and virion release. Potent repression was observed in primary human blood mononuclear cells and a subset of leukemia cell lines. However, the early steps of reverse transcription and integration appear to be unimpaired in nonpermissive cells. FeLV-B was subject to G→A hypermutation with a predominant APOBEC3G signature in partially permissive cells but was not mutated in permissive cells or in nonpermissive cells that block secondary viral spread. Distinct cellular barriers that protect primary human blood cells are likely to be important in protection against zoonotic infection with FeLV. Domestic exposure to gammaretroviruses such as feline leukemia viruses (FeLVs) occurs worldwide, but the basis of human resistance to infection remains incompletely understood. The potential threat is evident from the human genome sequence, which reveals many past epidemics of gammaretrovirus infection, and from recent cross-species jumps of gammaretroviruses from rodents to primates and marsupials. This study examined resistance to infection at the cellular level with the most prevalent human cell-tropic FeLV variant, FeLV-B. We found that blood cells are uniquely resistant to infection with FeLV-B due to the activity of cellular enzymes that mutate the viral genome. A second block, which appears to suppress viral gene expression after the viral genome has integrated into the host cell genome, was identified. Since cells derived from other normal human cell types are fully supportive of FeLV replication, innate resistance of blood cells could be critical in protecting against cross-species infection.
[Mh] Termos MeSH primário: Vírus da Leucemia Felina/fisiologia
Infecções por Retroviridae/virologia
[Mh] Termos MeSH secundário: Desaminase APOBEC-3G/genética
Desaminase APOBEC-3G/metabolismo
Animais
Gatos
Linhagem Celular Tumoral
Suscetibilidade a Doenças
Expressão Gênica
Genoma Viral
Células HEK293
Seres Humanos
Mutação
Especificidade da Espécie
Tropismo Viral
Integração Viral
Replicação Viral
Zoonoses/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.5.4.5 (APOBEC-3G Deaminase); EC 3.5.4.5 (APOBEC3G protein, human)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE


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[PMID]:28005210
[Au] Autor:Kawamura M; Umehara D; Odahara Y; Miyake A; Ngo MH; Ohsato Y; Hisasue M; Nakaya MA; Watanabe S; Nishigaki K
[Ad] Endereço:Laboratory of Molecular Immunology and Infectious Disease, The United Graduate School of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.
[Ti] Título:AKT capture by feline leukemia virus.
[So] Source:Arch Virol;162(4):1031-1036, 2017 Apr.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Oncogene-containing retroviruses are generated by recombination events between viral and cellular sequences, a phenomenon called "oncogene capture". The captured cellular genes, referred to as "v-onc" genes, then acquire new oncogenic properties. We report a novel feline leukemia virus (FeLV), designated "FeLV-AKT", that has captured feline c-AKT1 in feline lymphoma. FeLV-AKT contains a gag-AKT fusion gene that encodes the myristoylated Gag matrix protein and the kinase domain of feline c-AKT1, but not its pleckstrin homology domain. Therefore, it differs structurally from the v-Akt gene of murine retrovirus AKT8. AKT may be involved in the mechanisms underlying malignant diseases in cats.
[Mh] Termos MeSH primário: Doenças do Gato/genética
Vírus da Leucemia Felina/genética
Proteínas Proto-Oncogênicas c-akt/genética
Recombinação Genética
Infecções por Retroviridae/veterinária
Infecções Tumorais por Vírus/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças do Gato/enzimologia
Doenças do Gato/virologia
Gatos
Vírus da Leucemia Felina/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Infecções por Retroviridae/enzimologia
Infecções por Retroviridae/genética
Infecções por Retroviridae/virologia
Infecções Tumorais por Vírus/enzimologia
Infecções Tumorais por Vírus/genética
Infecções Tumorais por Vírus/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170315
[Lr] Data última revisão:
170315
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-016-3192-1


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[PMID]:26965677
[Ti] Título:Clinical, pathological, immunohistochemical and molecular characterization of feline chronic gingivostomatitis.
[So] Source:J Feline Med Surg;19(4):NP1, 2017 Apr.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Veronica Machado Rolim, Saulo Petinatti Pavarini, Fabrício Souza Campos, Viviam Pignone, Cláudia Faraco, Marcelo de Souza Muccillo, Paulo Michel Roehe, Fernanda Viera Amorim da Costa, and David Driemeier J Feline Med Surg. Epub ahead of print 8 February 2016. DOI: 10.1177/1098612X16628578.
[Mh] Termos MeSH primário: Doenças do Gato/diagnóstico
Gengivite/veterinária
[Mh] Termos MeSH secundário: Animais
Caliciviridae/isolamento & purificação
Doenças do Gato/patologia
Doenças do Gato/virologia
Gatos
DNA Viral/análise
Feminino
Gengivite/diagnóstico
Imuno-Histoquímica/veterinária
Vírus da Leucemia Felina/isolamento & purificação
Masculino
Reação em Cadeia da Polimerase/veterinária
Estomatite/diagnóstico
Estomatite/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160312
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X16639004


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Roehe, Paulo Michel
Texto completo
[PMID]:26858258
[Au] Autor:Rolim VM; Pavarini SP; Campos FS; Pignone V; Faraco C; Muccillo MS; Roehe PM; da Costa FV; Driemeier D
[Ad] Endereço:1 Department of Veterinary Pathology of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
[Ti] Título:Clinical, pathological, immunohistochemical and molecular characterization of feline chronic gingivostomatitis.
[So] Source:J Feline Med Surg;19(4):403-409, 2017 Apr.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives This study presents the clinical, pathological, immunohistochemical and molecular characterization of 26 cats with feline chronic gingivostomatitis (FCG). Methods Oral mucosal biopsies, blood and swabs were collected from cats presenting with oral lesions. The tissue sections were submitted for histopathology and immunohistochemical analysis for feline calicivirus (FCV), feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV). The swabs were subjected to PCR analysis for FCV, and blood for FeLV and FIV. Results The main clinical findings were dysphagia (88.2%), halitosis (76.5%), sialorrhea (47.1%), weight loss (41.2%), intense oral discomfort (35.3%), oral hemorrhage (17.6%), and lackluster and fragile coat (11.8%). Gross inspection revealed bilateral lesions across the palatoglossal fold to the lateral tongue base. The lesions were diffuse, proliferative, intensely red and friable, and bled easily upon examination in 80.8% of cases. In 23.1% of cases, the lesions were multifocal to coalescent, at times forming multiple vesicles on a reddened, edematous palatoglossal fold. Microscopic examination showed that 15.4% of lesions had moderate (grade 2) and 84.6% had severe (grade 3) inflammation. Immunohistochemistry revealed the presence of FeLV antigens in the epithelium and the inflammatory infiltrate of 30.8% of the cats with FCG. FCV antigens were not detected in the FCG lesions. Conclusions and relevance The FCG cases analyzed could not be correlated with FCV. It is possible that FeLV plays a role as a causal agent of lesions in cases where the presence of the virus has been confirmed by immunohistochemistry in epithelial samples.
[Mh] Termos MeSH primário: Doenças do Gato/diagnóstico
Gengivite/veterinária
Estomatite/veterinária
[Mh] Termos MeSH secundário: Animais
Caliciviridae/isolamento & purificação
Doenças do Gato/sangue
Doenças do Gato/patologia
Doenças do Gato/virologia
Gatos
Feminino
Gengivite/diagnóstico
Vírus da Imunodeficiência Felina/isolamento & purificação
Imuno-Histoquímica/veterinária
Vírus da Leucemia Felina/isolamento & purificação
Masculino
Reação em Cadeia da Polimerase/veterinária
Estomatite/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160210
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X16628578



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