Base de dados : MEDLINE
Pesquisa : B04.820 [Categoria DeCS]
Referências encontradas : 7174 [refinar]
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  1 / 7174 MEDLINE  
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[PMID]:29324229
[Au] Autor:Jones MK; Karst SM
[Ad] Endereço:Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA.
[Ti] Título:Enteric Viruses Hitch a Ride on the Evolutionary Highway.
[So] Source:Cell Host Microbe;23(1):5-6, 2018 01 10.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RNA viruses can recombine their genetic material during co-infection. However, the in vivo frequency of co-infections is unclear. In this issue of Cell Host & Microbe, Erickson et al. (2018) demonstrate that an enteric RNA virus concentrates itself through multi-virion binding to bacteria, thus increasing genetic recombination and virus adaptability.
[Mh] Termos MeSH primário: Evolução Biológica
Vírus de RNA/genética
[Mh] Termos MeSH secundário: Coinfecção
Vírus de DNA
Vírus
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  2 / 7174 MEDLINE  
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[PMID]:29218572
[Au] Autor:Peng X; Pan H; Muhammad A; An H; Fang S; Li W; Zhang S
[Ad] Endereço:Engineering Research Centre of Ecology and Agricultural Use of Wetland, Ministry of Education, Hubei Collaborative Innovation Center for Grain Industry, Yangtze University, Jingzhou, 434025, Hubei, China.
[Ti] Título:Complete genome sequence of a new strain of Lagenaria siceraria endornavirus from China.
[So] Source:Arch Virol;163(3):805-808, 2018 Mar.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:An RNA virus tentatively named Lagenaria siceraria endornavirus-Hubei (LsEV-HuB) was isolated from Lagenaria siceraria var. hispida in Hubei, China. The LsEV-HuB genome consists of 15,098 bp and contains a single open reading frame (ORF) encoding a large protein with several conserved domains, including one helicase domain, one glycosyltransferase domain, two capsular polysaccharide synthesis protein (CPS) domains, and one RNA-dependent RNA polymerase (RdRp) domain. LsEV-HuB has nucleotide and amino acid sequence identities of 72.96% and 77.95%, respectively, to Lagenaria siceraria endornavirus-California (LsEV-CA), the closest relative of LsEV-HuB.
[Mh] Termos MeSH primário: Cucurbitaceae/virologia
DNA Viral/genética
Genoma Viral
Filogenia
Poliproteínas/genética
Vírus de RNA/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
China
Tamanho do Genoma
Fases de Leitura Aberta
Doenças das Plantas/virologia
Vírus de RNA/classificação
Vírus de RNA/isolamento & purificação
Recombinação Genética
Análise de Sequência de DNA
Homologia de Sequência de Aminoácidos
Sequenciamento Completo do Genoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 0 (Polyproteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3664-y


  3 / 7174 MEDLINE  
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[PMID]:28468626
[Au] Autor:Xu Q; Liu H; Yuan P; Zhang X; Chen Q; Jiang X; Zhou Y
[Ad] Endereço:Institute of Plant Protection; Jiangsu Academy of Agricultural Sciences; Jiangsu Technical Service Center of Diagnosis and Detection for Plant Virus Diseases, Nanjing, Jiangsu, People's Republic of China.
[Ti] Título:Development of a simplified RT-PCR without RNA isolation for rapid detection of RNA viruses in a single small brown planthopper (Laodelphax striatellus Fallén).
[So] Source:Virol J;14(1):90, 2017 05 03.
[Is] ISSN:1743-422X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The small brown planthopper (SBPH) is an important pest of cereal crops and acts as a transmission vector for multiple RNA viruses. Rapid diagnosis of virus in the vector is crucial for efficient forecast and control of viral disease. Reverse transcription polymerase chain reaction (RT-PCR) is a rapid, sensitive and reliable method for virus detection. The traditional RT-PCR contains a RNA isolation step and is widely used for virus detection in insect. However, using the traditional RT-PCR for detecting RNA virus in individual SBPHs becomes challenging because of the expensive reagents and laborious procedure associated with RNA isolation when processing a large number of samples. RESULTS: We established a simplified RT-PCR method without RNA isolation for RNA virus detection in a single SBPH. This method is achieved by grinding a single SBPH in sterile water and using the crude extract directly as the template for RT-PCR. The crude extract containing the virus RNA can be prepared in approximately two minutes. Rice stripe virus (RSV), rice black streaked dwarf virus (RBSDV) and Himetobi P virus (HiPV) were successfully detected using this simplified method. The detection results were validated by sequencing and dot immunobinding assay, indicating that this simplified method is reliable for detecting different viruses in insects. The evaluation of the sensitivity of this method showed that both RSV and HiPV can be detected when the cDNA from the crude extract was diluted up to 10 fold. Compared to the traditional RT-PCR with RNA isolation, the simplified RT-PCR method greatly reduces the sample processing time, decreases the detection cost, and improves the efficiency by avoiding RNA isolation. CONCLUSIONS: A simplified RT-PCR method is developed for rapid detection of RNA virus in a single SBPH without the laborious RNA isolation step. It offers a convenient alternative to the traditional RT-PCR method.
[Mh] Termos MeSH primário: Hemípteros/virologia
Insetos Vetores/virologia
Vírus de RNA/isolamento & purificação
RNA Viral/isolamento & purificação
Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos
[Mh] Termos MeSH secundário: Animais
DNA Complementar/isolamento & purificação
Dicistroviridae/genética
Dicistroviridae/isolamento & purificação
Immunoblotting/métodos
Insetos/virologia
Vírus de Plantas/genética
Vírus de Plantas/isolamento & purificação
RNA Viral/análise
Reoviridae/genética
Reoviridae/isolamento & purificação
Sensibilidade e Especificidade
Tenuivirus/genética
Tenuivirus/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (RNA, Viral)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12985-017-0732-6


  4 / 7174 MEDLINE  
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[PMID]:29182522
[Au] Autor:Losdorfer Bozic A; Podgornik R
[Ad] Endereço:Department of Theoretical Physics, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia.
[Ti] Título:Varieties of charge distributions in coat proteins of ssRNA+ viruses.
[So] Source:J Phys Condens Matter;30(2):024001, 2018 Jan 17.
[Is] ISSN:1361-648X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A major part of the interactions involved in the assembly and stability of icosahedral, positive-sense single-stranded RNA (ssRNA+) viruses is electrostatic in nature, as can be inferred from the strong pH- and salt-dependence of their assembly phase diagrams. Electrostatic interactions do not act only between the capsid coat proteins (CPs), but just as often provide a significant contribution to the interactions of the CPs with the genomic RNA, mediated to a large extent by positively charged, flexible N-terminal tails of the CPs. In this work, we provide two clear and complementary definitions of an N-terminal tail of a protein, and use them to extract the tail sequences of a large number of CPs of ssRNA+ viruses. We examine the pH-dependent interplay of charge on both tails and CPs alike, and show that-in contrast to the charge on the CPs-the net positive charge on the N-tails persists even to very basic pH values. In addition, we note a limit to the length of the wild-type genomes of those viruses which utilize positively charged tails, when compared to viruses without charged tails and similar capsid size. At the same time, we observe no clear connection between the charge on the N-tails and the genome lengths of the viruses included in our study.
[Mh] Termos MeSH primário: Proteínas do Capsídeo
Capsídeo/química
Vírus de RNA/química
RNA/química
[Mh] Termos MeSH secundário: Modelos Moleculares
Eletricidade Estática
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins); 63231-63-0 (RNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1088/1361-648X/aa9ded


  5 / 7174 MEDLINE  
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[PMID]:29111455
[Au] Autor:Shi M; Zhang YZ; Holmes EC
[Ad] Endereço:Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.
[Ti] Título:Meta-transcriptomics and the evolutionary biology of RNA viruses.
[So] Source:Virus Res;243:83-90, 2018 01 02.
[Is] ISSN:1872-7492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Metagenomics is transforming the study of virus evolution, allowing the full assemblage of virus genomes within a host sample to be determined rapidly and cheaply. The genomic analysis of complete transcriptomes, so-called meta-transcriptomics, is providing a particularly rich source of data on the global diversity of RNA viruses and their evolutionary history. Herein we review some of the insights that meta-transcriptomics has provided on the fundamental patterns and processes of virus evolution, with a focus on the recent discovery of a multitude of novel invertebrate viruses. In particular, meta-transcriptomics shows that the RNA virus world is more fluid than previously realized, with relatively frequent changes in genome length and structure. As well as having a transformative impact on studies of virus evolution, meta-transcriptomics presents major new challenges for virus classification, with the greater sampling of host taxa now filling many of the gaps on virus phylogenies that were previously used to define taxonomic groups. Given that most viruses in the future will likely be characterized using metagenomics approaches, and that we have evidently only sampled a tiny fraction of the total virosphere, we suggest that proposals for virus classification pay careful attention to the wonders unearthed in this new age of virus discovery.
[Mh] Termos MeSH primário: Evolução Molecular
Infecções por Vírus de RNA/virologia
Vírus de RNA/genética
[Mh] Termos MeSH secundário: Animais
Genoma Viral
Seres Humanos
Metagenômica
Filogenia
Vírus de RNA/classificação
Vírus de RNA/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171108
[St] Status:MEDLINE


  6 / 7174 MEDLINE  
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[PMID]:29054449
[Au] Autor:Jiang Z; Li Z; Yue N; Zhang K; Li D; Zhang Y
[Ad] Endereço:State Key Laboratory of Agro-Biotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, P.R. China.
[Ti] Título:Construction of infectious clones of lychnis ringspot virus and evaluation of its relationship with barley stripe mosaic virus by reassortment of genomic RNA segments.
[So] Source:Virus Res;243:106-109, 2018 01 02.
[Is] ISSN:1872-7492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Lychnis ringspot virus (LRSV, genus Hordeivirus) was first isolated in 1959, and has been shown to infect several dicot plants in nature. However, due to the lack of infectious cDNA clones, the biological properties and mechanisms underlying LRSV infection are obscure. In this work, we constructed infectious cDNA clones of LRSV and have compiled the complete LRSV genomic (g) RNA sequence. Comparison of nucleotide and amino acid sequences between LRSV and barley stripe mosaic virus (BSMV), the type member of genus Hordeivirus, reveals that despite belonging to the same genus, and replicating in chloroplasts, the viruses are only distantly related. This could be further indicated by the failure of different LRSV/BSMV reassortants to infect N. benthamiana. LRSV infectious cDNA clones provide a useful tool for studies of biological diversity among hordeiviruses, and also may contribute to the understanding of seed transmission in dicot plants.
[Mh] Termos MeSH primário: Lychnis/virologia
Doenças das Plantas/virologia
Vírus de Plantas/genética
Vírus de RNA/genética
RNA Viral/genética
Recombinação Genética
[Mh] Termos MeSH secundário: Genoma Viral
Hordeum/virologia
Vírus de Plantas/classificação
Vírus de Plantas/isolamento & purificação
Vírus de Plantas/fisiologia
Vírus de RNA/classificação
Vírus de RNA/isolamento & purificação
Vírus de RNA/fisiologia
RNA Viral/metabolismo
Vírus Reordenados/classificação
Vírus Reordenados/genética
Vírus Reordenados/isolamento & purificação
Vírus Reordenados/fisiologia
Proteínas Virais/genética
Proteínas Virais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Viral); 0 (Viral Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171022
[St] Status:MEDLINE


  7 / 7174 MEDLINE  
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[PMID]:29050792
[Au] Autor:Sakuna K; Elliman J; Owens L
[Ad] Endereço:College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, 4811, Australia; Faculty of Veterinary Science, Rajamangala University of Technology Srivijaya, 80240, Thailand.
[Ti] Título:Comparison of molecular detection PCR methods for chequa iflavirus in freshwater crayfish, Cherax quadricarinatus.
[So] Source:J Virol Methods;251:139-144, 2018 Jan.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chequa iflavirus (+ve sense ssRNA virus) infects redclaw crayfish (Cherax quadricarinatus) and it may cause mortality reaching 20-40% after about three weeks following stress. The sequence of the RNA-dependent RNA polymerase at nucleotide position 8383-9873 was used for developing and comparing PCR-based detection protocols. The reverse transcription, quantitative, polymerase chain reaction (RT-qPCR) was specific against nine Picornavirales and crustacean viruses and its' measurement of uncertainty (0.07-1.37) was similar to PCRs for other crustacean viruses. In vitro, the reverse transcription loop-mediated isothermal amplification (RT-LAMP) read at 60min had poor repeatability for a linearized plasmid with an iflavirus insert when compared with RT-PCR visualised on an electrophoretic gel and RT-qPCR; both sensitive to 10 copies. In a limited, comparative sample of clinical crayfish haemolymph, the lowest, non-zero copies were 2.88×10 for RT-PCR and 4.60×10 for the RT-qPCR. In 68 further clinical crayfish haemolymph samples tested by RT-qPCR only, copy numbers ranged from 0 to 1.14×10 . For RT-qPCR, the amplification plots, melt curves and the C values indicated that the C above 34.0 is a potential negative result but examination of the melt curve is necessary for an accurate interpretation. A suggested program of testing for crayfish farmers would consist of non-destructive bleeding, labelling of crayfish and screening with RT-qPCR. Only those crayfish nominally negative (below detectable limits) would be used for broodstock or selective breeding.
[Mh] Termos MeSH primário: Astacoidea/virologia
Técnicas de Diagnóstico Molecular/métodos
Técnicas de Amplificação de Ácido Nucleico/métodos
Infecções por Vírus de RNA/veterinária
Vírus de RNA/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Água Doce
Infecções por Vírus de RNA/virologia
Vírus de RNA/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE


  8 / 7174 MEDLINE  
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[PMID]:29220409
[Au] Autor:Mata CP; Luque D; Gómez-Blanco J; Rodríguez JM; González JM; Suzuki N; Ghabrial SA; Carrascosa JL; Trus BL; Castón JR
[Ad] Endereço:Department of Structure of Macromolecules, Centro Nacional de Biotecnología (CNB-CSIC), Campus Cantoblanco, Madrid, Spain.
[Ti] Título:Acquisition of functions on the outer capsid surface during evolution of double-stranded RNA fungal viruses.
[So] Source:PLoS Pathog;13(12):e1006755, 2017 Dec.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Unlike their counterparts in bacterial and higher eukaryotic hosts, most fungal viruses are transmitted intracellularly and lack an extracellular phase. Here we determined the cryo-EM structure at 3.7 Å resolution of Rosellinia necatrix quadrivirus 1 (RnQV1), a fungal double-stranded (ds)RNA virus. RnQV1, the type species of the family Quadriviridae, has a multipartite genome consisting of four monocistronic segments. Whereas most dsRNA virus capsids are based on dimers of a single protein, the ~450-Å-diameter, T = 1 RnQV1 capsid is built of P2 and P4 protein heterodimers, each with more than 1000 residues. Despite a lack of sequence similarity between the two proteins, they have a similar α-helical domain, the structural signature shared with the lineage of the dsRNA bluetongue virus-like viruses. Domain insertions in P2 and P4 preferential sites provide additional functions at the capsid outer surface, probably related to enzyme activity. The P2 insertion has a fold similar to that of gelsolin and profilin, two actin-binding proteins with a function in cytoskeleton metabolism, whereas the P4 insertion suggests protease activity involved in cleavage of the P2 383-residue C-terminal region, absent in the mature viral particle. Our results indicate that the intimate virus-fungus partnership has altered the capsid genome-protective and/or receptor-binding functions. Fungal virus evolution has tended to allocate enzyme activities to the virus capsid outer surface.
[Mh] Termos MeSH primário: Proteínas do Capsídeo/metabolismo
Capsídeo/metabolismo
Modelos Moleculares
Vírus de RNA/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Capsídeo/enzimologia
Capsídeo/ultraestrutura
Proteínas do Capsídeo/química
Proteínas do Capsídeo/genética
Sequência Conservada
Microscopia Crioeletrônica
Evolução Molecular
Imagem Tridimensional
Mutagênese Insercional
Conformação Proteica em alfa-Hélice
Conformação Proteica em Folha beta
Domínios e Motivos de Interação entre Proteínas
Multimerização Proteica
Estabilidade Proteica
Vírus de RNA/enzimologia
Vírus de RNA/genética
Vírus de RNA/ultraestrutura
Alinhamento de Sequência
Homologia Estrutural de Proteína
Propriedades de Superfície
Vírion/enzimologia
Vírion/genética
Vírion/metabolismo
Vírion/ultraestrutura
Xylariales/virologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006755


  9 / 7174 MEDLINE  
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[PMID]:29261772
[Au] Autor:Bradford EL; Christie CR; Campbell EM; Bowman AS
[Ad] Endereço:Institute of Biological and Environmental Sciences, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom.
[Ti] Título:A real-time PCR method for quantification of the total and major variant strains of the deformed wing virus.
[So] Source:PLoS One;12(12):e0190017, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:European honey bees (Apis mellifera) are critically important to global food production by virtue of their pollination services but are severely threatened by deformed wing virus (DWV) especially in the presence of the external parasite Varroa destructor. DWV exists as many viral strains with the two major variants (DWV-A and DWV-B) varying in virulence. A single plasmid standard was constructed containing three sections for the specific determination of DWV-A (VP2 capsid region), DWV-B (IRES) and a conserved region suitable for total DWV (helicase region). The assays were confirmed as specific and discriminatory with limits of detections of 25, 25 and 50 genome equivalents for DWV-A, DWV-B and total-DWV, respectively. The methods were successfully tested on Apis mellifera and V. destructor samples with varying DWV profiles. The new method determined a more accurate total DWV titre in samples with substantial DWV-B than the method currently described in the COLOSS Beebook. The proposed assays could be utilized for the screening of large quantities of bee material for both a total DWV load overview along with more detailed investigations into DWV-A and DWV-B profiles.
[Mh] Termos MeSH primário: Vírus de RNA/genética
Reação em Cadeia da Polimerase em Tempo Real/métodos
Asas de Animais/virologia
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Abelhas/parasitologia
Abelhas/virologia
Padrões de Referência
Incerteza
Varroidae/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190017


  10 / 7174 MEDLINE  
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[PMID]:28448634
[Au] Autor:Smith EC
[Ad] Endereço:Department of Biology, Sewanee: The University of the South, Sewanee, Tennessee, United States of America.
[Ti] Título:The not-so-infinite malleability of RNA viruses: Viral and cellular determinants of RNA virus mutation rates.
[So] Source:PLoS Pathog;13(4):e1006254, 2017 04.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Genes Virais/genética
Taxa de Mutação
Mutação
Vírus de RNA/genética
[Mh] Termos MeSH secundário: RNA Viral/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006254



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